KR100511341B1 - Ultrasonic gel pad containing carrageenan and its preparation - Google Patents

Abstract

The present invention relates to an ultrasonic gel pad and a method for manufacturing the same, and more specifically, 0.1-10% by weight of carrageenan, 0-10% by weight of polyhydric alcohol, 0.005-0.6% by weight of preservative, and then stirred in an aqueous solution. Preparing step (step 1); Pour the aqueous solution of step 1 into a tray and forming a gel by maintaining the aqueous solution temperature at 10 to 40 ℃ (step 2); and packaging the sheet of step 2 (step 3) relates to a gel pad manufacturing method for ultrasound will be.

The gel pad of the present invention has a gel strength and flexibility suitable for use in ultrasound diagnosis, is not contaminated with mold and bacteria, has a long shelf life and excellent shelf life, and uses a skin-friendly material, which is harmless to skin and has a moisturizing effect. It is excellent, especially in the case of using the human body in the apparent bent portion or the near field (Near Field) as an interlayer medium in the diagnosis and treatment of ultrasound, the resolution and clarity of the image is excellent. In addition, according to the manufacturing method of the present invention, since the tray is used, gel pads having various shapes, sizes, and thicknesses can be easily manufactured.

Description

Ultrasonic gel pad containing carrageenan and its manufacturing method {Ultrasonic gel pad containing carrageenan and its preparation}

The present invention relates to a gel pad for ultrasound and a method of manufacturing the same, and more particularly, has a gel strength and flexibility suitable for use in ultrasound diagnostics, is not contaminated with mold and bacteria and has a long shelf life and excellent shelf life, It is made of friendly materials, which is harmless to the skin and has excellent moisturizing effect. Especially, when the human body part in the appearance of bend or near field is used as an intermediate layer for ultrasound diagnosis and treatment, the image resolution and clarity are excellent. The present invention relates to an ultrasonic gel pad and a method of manufacturing the same.

Ultrasound is a sound wave with a frequency of about 20,000 Hz or more that cannot be felt by the human ear, and is essentially the same as the sound wave in the audible range. However, since the frequency is high and thus the wavelength is short, a very strong vibration is generated, which is not seen in normal sound waves. For example, a short pulse comes out while the path is directional. By using these properties of ultrasound, the medical field is using ultrasound to obtain an image of the internal structure of the human body. Ultrasound examination is a graphic image of signals reflected from each organ by emitting sound waves of high frequency (3 MHz to 25 MHz) to the human body and viewing the tomography of the body with a computer. It is widely used to diagnose visceral condition, and is widely used in ultrasound physiotherapy in rehabilitation therapy. In the ultrasound examination and treatment, a medium called an interphase is required to prevent sound waves from scattering in the air when the ultrasound is propagated inside the human body. In other words, in order to propagate the ultrasonic waves inside the human body, an intermediate layer is required as the ultrasonic transmission medium in order to spread the sound waves evenly and to allow the reflected sound wave signals to reach the receiver completely. This intermediate layer is usually used in the form of a gel product.

However, these gel-form products are not suitable for visualizing images of organs in apparent curves or near fields. That is, when the gel-like product is used as an intermediate layer in the ultrasonic examination for obtaining the structure of organs in the appearance of the bent portion or the near field, the resolution and the sharpness of the image are inferior. On the other hand, the near field is also called a near sound field and is a very close area to a sound source, and generally means a distance range smaller than the wavelength of the lowest frequency emitted from the sound source.

The present inventors have conducted research to solve the above problems, and when using a gel pad containing carrageenan, polyhydric alcohol and preservatives as an intermediate layer during ultrasound examination, by securing an appropriate distance from the sound source, the appearance bend or near field (Near Field) The present invention was completed by confirming that images of organs in the body are more clearly visualized and having suitable physical properties and storage properties for use.

Therefore, the technical problem to be achieved by the present invention is to provide a gel pad for ultrasound suitable for use as an intermediate layer during the ultrasound test.

Still another object of the present invention is to provide a method for producing the gel pad.

In order to achieve the above object, the present invention provides a gel pad for ultrasound consisting of carrageenan, polyhydric alcohol, preservatives and water balance.

Ultrasonic gel pads have a number of functional advantages, but if the mechanical properties are not satisfied, there are many handling problems. In order to overcome this problem, an appropriate polymer and a polymer having an optimal molecular weight should be selected. In particular, in the case of a polymer having a high molecular weight, phase compatibility may occur when the components are not compatible with each other, resulting in deterioration of final physical properties.

Therefore, in the present invention, the carrageenan is selected as an appropriate polymer in consideration of these factors, and the physical crosslinked structure through the carrageenan is induced to have suitable physical properties as the gel pad for ultrasound.

 Carrageenan is used as a gelling agent in the present invention, and is a natural high molecular material produced from red head, rockfish, and the like of red algae. Carrageenan is a complex polysaccharide extracted from red algae that grows in clean waters, and is used as a dispersant, emulsion stabilizer, swelling agent, thickener, binder, dietary fiber, crystallization agent and gelling agent in food applications. In addition to food, it is expected to be applied in medicine, cosmetics and other fields. In general, carrageenan is an anionic polymer with sulfuric acid groups showing strong hydrophilicity, and kappa-, κ-, lambda-, lambda-, and iota-, ι depending on the content and position of the sulfate group. -), Mu- (mu-, μ-)-furselaran (-furcellaran) form is divided into, and is commercialized in the form of a single or mixed with each other. Usually, three kinds of carrageenan of kappa-, lambda-, and iota-type are mainly used. One of the characteristics of these carrageenan is that it is easily gelled by cations and has excellent film forming ability. In particular, the carrageenan used in the present invention is preferably kappa-carrageenan, which gels best among the three kinds of carrageenan. The molecular structure of kappa-carrageenan is shown in FIG. In particular, in the present invention, carrageenan is dissolved in water at 70 to 90 ° C., and then poured into a mold, a tray, and then used for the ultrasonic wave by physical crosslinking, not chemical synthesis, by using the properties of carrageenan which becomes a gel at a temperature of 40 ° C. or less. By preparing a gel pad, gelling agents or preservatives commonly used in ultrasonic gels may be prepared through chemical synthesis, thereby improving the problem of causing allergic reactions or contact dermatitis during skin application.

The polyhydric alcohol is used to prevent evaporation of the water of the gel pad and to soften the gel pad. Preferably, the polyhydric alcohol has a molecular weight of 200 to 8000. It is because it is difficult to manufacture a uniform gel pad because it has incompatibility with other components when it has a molecular weight more than that.

Specific examples of the polyhydric alcohols that can be used include ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, glycerin, polyethylene glycol, polypropylene glycol, sorbitol, mannitol, and mixtures thereof. Among them, polyethylene glycol, propylene glycol or glycerin is particularly preferable as a water-soluble compound which is harmless to the human body and has excellent biocompatibility. It is preferable that especially the molecular weight of polyethyleneglycol is 300-600. Polyethylene glycol having a higher molecular weight is in a solid phase, when mixed with other polymers, it is difficult to prepare a uniform gel because of poor compatibility with materials. The molecular structure of polyethylene glycol is shown in FIG.

Preservatives include Bronopol (2-bromo-2-nitropropane-1,3-diol), methylparaben (methyl p-oxybenzoate), ethyl paraben (ethyl p-oxybenzoate), and propyl paraben (propyl paraben: propyl). p-oxybenzoate), imidazolidinyl urea, and mixtures of these mixed appropriately can be used. In particular, since it is preferable that no preservatives are precipitated after preparation, Bronopol (2-bromo-2-nitropropane-1,3-diol) is preferable. Bronopol is well soluble in water, used in medicine and cosmetics, and has good skin affinity.

The present invention also provides a method for producing the gel pad.

Adding a carrageenan, a polyhydric alcohol, a preservative into water, and heating and stirring to prepare an aqueous solution (step 1); Pouring the aqueous solution of step 1 into a tray and maintaining the aqueous solution temperature at 10 to 40 ° C. to form a gel (step 2); and packaging the sheet of step 2 (step 3). to provide.

Specifically, first, a predetermined amount of carrageenan, polyhydric alcohol and preservative are put in water and stirred while heating the carrageenan at 70-90 ° C. for 3-4 hours to dissolve the carrageenan in water.

 At this time, carrageenan is preferably used in an amount of 0.1 to 10% by weight of the total weight in order to maintain the form of the aqueous solution before handling and easy to handle. When carrageenan increases by more than 10 weight% of the total weight of aqueous solution, a viscosity becomes high and it is difficult to melt | dissolve.

In addition, polyhydric alcohol mixes and uses 0-10 weight% of the total weight of aqueous solution. If the polyhydric alcohol increases by more than 10% by weight of the total aqueous solution, a gel strength suitable for use cannot be obtained.

The blending limit of the preservative in step 1 is preferably at most 0.6% by weight.

Carrageenan and polyalcohol in step 1 may be 3 to 40% by weight in aqueous solution, but 3 to 20% by weight is preferred. In case of less than 3% by weight, the gel strength suitable for use cannot be obtained. In the case of more than 20% by weight, the viscosity of the aqueous polymer solution is too large to make a sheet.

Therefore, it is preferable to include carrageenan 0.1 to 10% by weight, polyhydric alcohol 0 to 10% by weight, and preservative 0.005 to 0.6% by weight in order to make a gel pad having gel strength and flexibility suitable for use with various functional advantages. Do.

The aqueous solution obtained in step 1 is poured into a tray in step 2, and is formed into a gel by maintaining the temperature of the aqueous solution at 40 ° C. or less, especially at room temperature. When the temperature of the aqueous solution obtained in step 1 is lowered below 40 ° C, the gel solidifies due to the characteristics of carrageenan.

The tray may use trays of various diameters, heights and shapes, and the like, and gel pads having a desired shape and size may be manufactured by using various trays.

The gel pad prepared in sheet form in step 2 is packaged in step 3 above. Conventional packaging materials can be used for the packaging, and polymer films such as polyethylene, polypropylene, polyvinyl chloride, nylon, polyester, or the like, or aluminum foil, or laminates of aluminum and polymer films can be used.

 2 shows a manufacturing process of the gel pad for ultrasound.

According to an embodiment of the present invention, the gel pad of the present invention has a gel strength and flexibility that is suitable for use in ultrasound diagnosis, is not contaminated with mold and bacteria, the usable period is long, and the shelf life is excellent, and the human part in the near field The resolution and clarity of the images were excellent when used for ultrasound diagnosis.

Hereinafter, the present invention will be described in more detail by the following examples.

However, the following examples are illustrative of the present invention, and the content of the present invention is not limited by the examples.

Example 1

Carrageenan 3 wt%, bronopol 0.05 wt% and polyethylene glycol (PEG) 0, 1, 3, 5, 7 wt% was dissolved in water shaken at 90 ℃ for 3 hours. It was poured into trays (9 cm in diameter x 2 cm in height) by 127 g. Carrageenan aqueous solution containing bronopol or carrageenan and aqueous polyethylene glycol solution were kept at room temperature until it became a gel. The gel pad thus formed was packaged.

Example 2

Carrageenan 5 wt%, Bronopol 0.05 wt% and polyethylene glycol (PEG) 0, 1, 3, 5, 7 wt% was added to water and dissolved by shaking at 90 ℃ for 3 hours. It was poured into trays (9 cm in diameter x 2 cm in height) by 127 g. Carrageenan aqueous solution containing bronopol or carrageenan and aqueous polyethylene glycol solution were kept at room temperature until it became a gel. The gel pad thus formed was packaged.

Example 3

Carrageenan 7 wt%, Bronopol 0.05 wt% and polyethylene glycol (PEG) 0, 1, 3, 5, 7 wt% was dissolved in water shaken at 90 ℃ for 3 hours. It was poured into trays (9 cm in diameter x 2 cm in height) by 127 g. Carrageenan aqueous solution containing bronopol or carrageenan and aqueous polyethylene glycol solution were kept at room temperature until it became a gel. The gel pad thus formed was packaged.

Example 4

Carrageenan 5 wt%, polyethylene glycol (PEG) 3 wt% and methyl paraben 0, 0.1, 0.2, 0.3, 0.4, 0.5 wt% was added to the water and dissolved by shaking at 90 ℃ for 3 hours. It was poured into trays (9 cm in diameter x 2 cm in height) by 127 g. Carrageenan aqueous solution containing polyethyleneglycol or carrageenan and methylparaben aqueous solution were kept at room temperature until it became a gel. The gel pad thus formed was packaged.

Example 5

5 wt% of carrageenan, 3 wt% of polyethylene glycol (PEG) and 0, 0.025, 0.05, 0.075, 0.1 wt% of bronopol were added to water and dissolved by shaking at 90 ° C for 3 hours. It was poured into trays (9 cm in diameter x 2 cm in height) by 127 g. Carrageenan aqueous solution containing polyethyleneglycol or carrageenan and bronopol aqueous solution were kept at room temperature until it became a gel. The gel pad thus formed was packaged.

Example 6

5 wt% of carrageenan, 3 wt% of polyethylene glycol (PEG) and 0, 0.1, 0.2, 0.3, 0.4, 0.5 wt% of imidazolidinyl urea were added to water and dissolved by shaking at 90 ° C for 3 hours. It was poured into trays (9 cm in diameter x 2 cm in height) by 127 g. Carrageenan aqueous solution containing polyethyleneglycol or carrageenan and aqueous solution of imidazolidinyl urea were left at room temperature until it became a gel. The gel pad thus formed was packaged.

Example 7

5 wt% of carrageenan, 3 wt% of polyethylene glycol (PEG) and 0.05 wt% of bronopol were added to water and dissolved by shaking at 90 ° C. for 3 hours. It was poured into trays (9 cm in diameter x 2 cm in height) by 127 g. Carrageenan aqueous solution containing polyethyleneglycol or carrageenan and bronopol aqueous solution were kept at room temperature until it became a gel. The gel pad thus formed was packaged.

Comparative Example 1

Normally used ultrasonic gel was used as a comparative sample. As a comparison ultrasonic gel, 1% by weight carbopol 540 was added to a mixer at room temperature (25 to 30 ° C) in distilled water, stirred for about 2 hours, dissolved, and 1% by weight as a neutralizing agent. Triethanolamine was added thereto and stirred for 3 minutes to prepare an ultrasound diagnostic gel.

Experimental Example 1 Measurement of Tensile Strength

Tensile and compressive strengths of the gel pads prepared in Examples 1 to 3 were measured to determine whether they have suitable physical properties for use as an intermediate layer during ultrasonic examination.

Tensile strength of the gel pads was measured using an INSTRON Series IX (Instron Co., Universal Testing System Model 4400), which was taken out of the gel pads prepared in Examples 1-3. The thickness of the gel pad specimen for measuring tensile strength was 2 mm, width 10 mm and length 60 mm. The cross head speed was 15 mm / min and span length was 40 mm. Four samples were measured and averaged. The results are shown in FIG.

As shown in Figure 3, the carrageenan, bronopol and polyethylene glycol gel pads prepared in the Examples of the tensile strength was 0.02 ~ 1.95 kgf / cm ² This is a degree of tensile strength suitable for use as an ultrasonic gel pad. In addition, in the case of containing the same concentration of carrageenan, the tensile strength decreased as the concentration of polyethylene glycol increased, and in the case of the same polyethylene glycol concentration, the tensile strength increased as the concentration of carrageenan increased.

Experimental Example 2 Measurement of Compressive Strength

The gel pads prepared in Examples 1 and 2 were unpacked and taken out, and the compressive strength of the gel pads was measured using INSTRON Series IX (Instron Co., Universal Testing System Model 4400). The gel pad for measuring the compressive strength was 20 mm in thickness and 12 mm in diameter. When measuring the compressive strength, the cross head speed was 10 mm / min, and the value was measured when the gel pad was deformed 10%. Four samples of one type were measured and averaged. The result is shown in FIG.

As shown in Figure 4, the compressive strength of the carrageenan, bronopol and polyethylene glycol gel pad prepared in Example was 0.08 ~ 0.40 kgf / cm ² , which is a compressive strength suitable for use as an ultrasonic gel pad. In the case of containing the same concentration of carrageenan, the compressive strength decreased as the concentration of polyethylene glycol increased. In the case of the same polyethylene glycol concentration, the compressive strength increased as the concentration of carrageenan increased.

Experimental Example 3 Confirmation of Antifungal Properties

Ultrasonic gel pads containing methylparaben or bronopol as preservatives were investigated.

Carrageenan / polyethylene glycol ultrasonic gel pad without preservatives was placed in air at room temperature to allow mold to grow. The fungus grown on the gel pad was removed and put in PDB (Potato Dextrose Broth) solution and incubated at 25 ° C. 0.1 ml of the cultured solution and 20 ml of PDA (Potato Dextrose Agar) solution were added to each of four petri dishes (diameter 9 cm × 1.5 cm in height), shaken to mix evenly, and placed at room temperature until solidified to make PDA medium.

 The gel pads of Examples 4 and 5 were cut into circles 12 mm in diameter and 4 mm thick on the four PDA media prepared above, and placed on the PDA media at an appropriate distance. After incubating these four PDA media for 25 days in an oven at 25 ° C., the clear zone of the growth of the mold represented by methylparaben and bronopol was observed.

The results on the antifungal properties of methylparaben against the fungus are shown in FIG. 5a and the results on the antifungal properties of bronopol on the fungus are shown in FIG. 5b.

As shown in Figures 5a and 5b, the gel pad without the methyl paraben and 0.1% gel, the gel pad without bronopol did not show growth-lowering ring.

In addition, the diameter of each growth-lowering ring was measured, and the results are shown in Table 1.

(a) Growth hypolipidemic size of gel pad with varying concentration of methylparaben Methyl paraben concentration (wt%) Growth Jersey Ring Diameter (cm) 0 % 0 cm 0.1% 0 cm 0.2% 1.4 cm 0.3% 1.8 cm 0.4% 2.2 cm 0.5% 2.3 cm

(b) Growth hypolipidemic size of gel pad with bronopol concentration

Bronopol concentration (wt%) Growth Jersey Ring Diameter (cm) A B 0 % 0 cm 0 cm 0.025% 0 cm 4.0 cm 0.05% 1.5 cm 4.6 cm 0.075% 2.1 cm 5.1 cm 0.1% 2.7 cm 5.6 cm

As shown in Table 1, as the concentration of methyl paraben was increased, a broader growth-lowering ring was observed. When bronopol was added, the growth-lowering ring was divided into A and B. The area indicated by A is the area where bronopol completely prevented the growth of mold. The part labeled B contains the A region, which did not completely inhibit the growth of mold, but only a much smaller number of molds than the mold grown around the gel without bronopol. This overgrown area is shown. Growth-lowering ring A was not found in the gel without bronopol and the gel added with 0.025%, and as the concentration was increased, the growth-lowering ring was wider. Growth-lowering ring B did not appear only in the gel without bronopol, and when bronopol was added, broader growth-lowering ring was observed as the concentration of bronopol was increased.

Experimental Example 4 Confirmation of Antibacterial Activity

Ultrasound gel pads containing imidazolidinyl urea or bronopol as preservatives were examined for antibacterial properties.

E. Coli (Escherichia coli) and S. Aureus (Staphylococcus aureus) were incubated at 37 ° C in Nutrient Broth solution. Take 0.1 ml each of E. Coli culture and S. Aureus culture, add 20 ml of Nutrient Agar solution in a petri dish (9 cm in diameter × 1.5 cm in height), shake well, and leave it at room temperature until it solidifies. Made.

The gel pads of Examples 5 and 6 were cut into 12 mm diameter and 4 mm thick circles on four Nutrient Agar media made above, and placed at an appropriate distance. After 2 days incubation in an oven at 37 ° C., imidazolidinyl urea observed a clear zone for E. Coli and S. Aureus, and bronopol observed a growth low for E. Coli.

The results for the antibacterial activity of imidazolidinyl urea against E. Coli are shown in FIG. 6a, and the results for the antibacterial activity of imidazolidinyl urea for S. Aureus are shown in 6b, and for Bronopol for E. Coli. Results for antibacterial are shown in 6c.

As shown in Figures 6a, 6b and 6c, the gel without addition of imidazolidinyl urea or bronopol did not show growth-lowering ring.

In addition, the diameter of each growth-lowering ring was measured, and the results are shown in Table 2.

(a) Growth hypolipidemic size of gel pad with varying concentration of imidazolidinyl urea Imidazolidinyl urea concentration (wt%) Growth low ring diameter (cm) E. Coli S. Aureus 0% 0 cm 0 cm 0.1% 1.5 cm 1.4 cm 0.2% 1.8 cm 1.8 cm 0.3% 2.0 cm 2.0 cm 0.4% 2.1 cm 2.1 cm 0.5% 2.2 cm 2.2 cm

(b) Growth hypolipidemic size of gel pad with bronopol concentration

Bronopol concentration (wt%) Diameter of growth-lowering ring for E. Coli (cm) A B 0 % 0 cm 0 cm 0.025% 1.7 cm 1.7 cm 0.05% 1.9 cm 2.3 cm 0.075% 2.1 cm 2.6 cm 0.1% 2.3 cm 2.8 cm

 As shown in Table 2, as the concentration of imidazolidinyl urea was increased, a broader growth-lowering ring was observed. In addition, when bronopol was added, the growth-lowering ring was divided into A and B. A portion indicated by A is a region where bronopol completely prevented the growth of bacteria. The part labeled B contains the A region, but it did not completely inhibit the growth of bacteria, but only a much smaller number of bacteria than the bacteria grown around the gel without bronopol added because the growth of the bacteria was prevented due to the influence of bronopol. This overgrown area is shown. Growth-lowering ring A did not appear only in the gel without bronopol added, and as the concentration of bronopol was increased, a wider growth-lowering ring was observed. Growth-lowering ring B was not found in the gel without bronopol and 0.025% of the gel, and the growth-lowering ring could be seen as the concentration of bronopol was increased.

Experimental Example 5

The images of the gels for ultrasound and the gels for ultrasound of the present invention were used as the intermediate layer during the ultrasound examination.

Ultrasonic examination was performed using Comparative Example 1 and Example 7 as an intermediate | middle layer.

Digital Computered Ultrasound System HDI-3000 was used as the ultrasonic diagnostic device. The probe type was L type and the frequency was 5-10 MHz. The ultrasonography site was an epiphysis site where the fingertip and the backbone were convex and protruded when the fist was clenched.

First, the ultrasonic gel of Comparative Example 1 was evenly applied evenly to the pelvic region, and then rubbed the probe with a probe to check the image on the monitor. The image shown at this time, because the probe is moved along the surface of the bent portion, the curvature appears as a plane rather than appearing in three dimensions. On the other hand, when the gel pad for ultrasound of Example 7 was used as an intermediate layer between the probe and the skin, convex curvature of the epiphyseal region could be confirmed in three dimensions.

The gel pad of this invention was very effective at the time of the ultrasonic diagnosis of the body part which is difficult to diagnose when using the normal ultrasonic gel. In addition, the resolution and sharpness of the image were excellent.

In particular, the most effective part of the diagnosis using the gel pad of the present invention was gallbladder, breast, carotid artery, neonatal head, subcutaneous tissue, thyroid gland, testicle, etc., and the gel pad of the present invention secured an appropriate distance from the sound source. As a result, it was found that the image of the organs in the apparent curved part and the near field was more clearly visualized.

The gel pad of the present invention has a gel strength and flexibility suitable for use in ultrasound diagnosis, is not contaminated with mold and bacteria, has a long shelf life and excellent shelf life, and uses a skin-friendly material, which is harmless to skin and has a moisturizing effect. In particular, when the human body in the appearance of the bent portion or the near field (Near Field) is used as an intermediate layer medium for ultrasound diagnosis and treatment, the resolution and clarity of the image are excellent. In addition, according to the manufacturing method of the present invention, since the tray is used, gel pads having various shapes, sizes, and thicknesses can be easily manufactured.

Figure 1 shows the molecular structure of the carrageenan and polyhydric alcohol for ultrasound of the present invention,

Figure 2 shows the manufacturing process of the gel pad for ultrasound,

3 is a carrageenan concentration of 3, 5, 7% by weight, bronopol concentration of 0.05% by weight, showing the tensile strength of the carrageenan, bronopol and polyalcohol gel pad prepared by varying the concentration of polyhydric alcohol,

4 is a carrageenan concentration of 3, 5% by weight, bronopol concentration of 0.05% by weight, shows the compressive strength of carrageenan, bronopol and polyalcohol gel pad prepared by varying the concentration of polyhydric alcohol,

Figure 5a shows the antifungal properties of the gel pad according to the change in the concentration of methyl parabens,

Figure 5b shows the antifungal properties of the gel pad according to the concentration change of the bronopol,

Figure 6a shows the antibacterial to the E. Coli of the gel pad according to the concentration change of the preservative imidazolidinyl urea,

Figure 6b shows the antimicrobial activity of S. Aureus of the gel pad according to the concentration change of the preservative imidazolidinyl urea,

Figure 6c shows the antibacterial to E. Coli of the gel pad according to the change in the concentration of bronopol.

Claims (6)

A gel pad for ultrasonic waves comprising 0.1 to 10% by weight of carrageenan, 0 to 10% by weight of polyhydric alcohol, 0.005 to 0.6% by weight of preservative, and water balance. The gel pad according to claim 1, wherein the carrageenan is kappa-carrageenan and the molecular weight of the polyhydric alcohol is 200 to 8000. The group of claim 1 or 2, wherein the polyhydric alcohol is composed of ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, glycerin, polyethylene glycol, polypropylene glycol, sorbitol, mannitol, and mixtures thereof. Gel pad, characterized in that selected from. The method of claim 1 or 2, wherein the preservative is bronopol, methylparaben, ethylparaben, propylparaben, imidazolidinyl urea and mixtures thereof. Gel pad, characterized in that selected from the group consisting of. The ultrasonic gel pad according to claim 1 or 2, wherein the mixed concentration of carrageenan and polyhydric alcohol is 3 to 40% by weight based on water. Adding a carrageenan, a polyhydric alcohol, a preservative into water, and heating and stirring to prepare an aqueous solution (step 1); Pouring the aqueous solution of step 1 in a tray and molding the gel by maintaining the aqueous solution temperature at 10 ~ 40 ℃ (step 2); and the step of packaging the sheet of step 2 (step 3) method of producing a gel pad.