CN105327369A - Sterilizing-and-disinfecting-type coupling agent and preparing method thereof - Google Patents
Sterilizing-and-disinfecting-type coupling agent and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a sterilizing-and-disinfecting-type coupling agent and a preparing method thereof. The sterilizing-and-disinfecting-type coupling agent is prepared from, by mass, carbomer 940, propylene glycol, glycerine, vitamins B5, polyvinylpyrrolidone K30, triclosan, methyl parahydroxybenzoats, triethanolamine, lauryl sodium sulfate and purified water. Compared with the prior art, the sterilizing-and-disinfecting-type coupling agent is good in stickiness and skin compatibility, and has good infiltrating performance for the skin and an ultrasonic probe, and the problems that an existing coupling agent is poor in stickiness and excessively short in drying time can be solved; due to the synergistic effect of the triclosan and the methyl parahydroxybenzoats in the formula, the coupling agent achieves safe and stable sterilization and bacteriostasis; the cytotoxicity of the coupling agent is greatly reduced, and use safety is high; the skin irritation of the coupling agent is low, and repairing of injured skin can be promoted at the same time through components with the repairing function in the formula. The preparing method of the coupling agent is simple, and industrial production can be easily achieved.
Description
Technical field
The present invention relates to a kind of couplant and preparation method thereof, specifically a kind of bactericidal sterilization type medical ultrasonic coupling agent and preparation method thereof, belong to medical ultrasound imaging agent technical field.
Background technology
Ultrasonic is the sound wave of a kind of frequency more than 20000 hertz, ultrasonic energy is propagated to certain orientation, and can object be penetrated, if encounter obstacle, will echogenicity, not identical barrier will produce not identical echo, and this echo to be collected by instrument and is presented on screen by people, can be used for understanding the internal structure of object.
Utilize this principle, people by ultrasound wave for the diagnosis and treatment of human body diseases.Ultrasonicly propagate in human body, because the various tissue of human body has the property difference of acoustics, ultrasound wave produces reflection, refraction, scattering, diffraction, decay and sound sources two kinds of different tissues interfaces and receptor relative motion produces the physical characteristics such as Doppler frequency shift.Apply dissimilar diasonograph, adopt various checking method, receive these reflections, scattered signal, show the form of various tissue and pathological changes thereof, binding of pathological, clinical medicine, observe, analyze, sum up different reflexive properties, and diagnosis is made to diseased region, character and dysfunction degree.Many types of the diasonograph that clinical medicine is applied, as A type, Type B, M type, fan-shaped and doppler ultrasound type etc.Type B is wherein a kind of, and is most widely used general and easy one clinically.The various tangent plane graphics Web publishing that can be obtained each organ of human body viscera by B ultrasonic are clear.B ultrasonic compares the diagnosis being applicable to the multiple organ diseases such as liver, gallbladder kidney, bladder, uterus, ovary." B ultrasonic " said at ordinary times is exactly to human-body emitting ultrasound wave, accepts the echo of internal organs of the body simultaneously, by taken message reflection on screen.
Because medical supersonic wave frequency is 2.5-5M, can not conduct in atmosphere.When detecting, as the probe of ultrasonic diagnostic equipment and the skin gap at human detection position exist air, just returning when ultrasound wave runs into air, cannot enter in body, then can not realize ultrasound detection.Therefore, in the diagnostic ultrasound procedures of reality, often need to be aided with ultrasonic coupling agent to carry out.First the effect of ultrasonic coupling agent is the slight void between filling ultrasonic probe and skin contact, and reducing or offsetting interstitial micro-air affects ultrasonic penetration body; Next is by couplant " transition " effect, the acoustic impedance difference between probe and skin is reduced, thus reduces the reflection loss of ultrasonic energy at this interface.In addition, effect that ultrasonic coupling agent also plays " lubrication ", reduces the friction between probe face and skin, probe can be slided flexibly and detect.
Medical ultrasonic coupling agent is a kind of entrant sound medium being widely used in ultrasonic diagnosis and treatment, in ultrasonic diagnosis and treatment operation, medical ultrasonic coupling agent is filled or is coated between skin-mucosa and probe (or treating head) radiating surface, for projecting intermediary's medium of sound wave.The ultrasonic diagnosis and treatment that Hospitals at Present uses has been employed for each section office, such as common gynaecologic vaginal ultrasonic examination; The two dimension of fetus, three-dimensional type-B ultrasonic inspection; The ultrasonic examination such as urinary system, cardiovascular system.Due to when being used to ultrasonic diagnosis and treatment, be often applied to different individual patients and ultrasonic probe; Therefore, these are popped one's head in or repeat to be utilized medical ultrasonic coupling agent inevitably with some malignant bacteria or fungus.Generally all be added with antibacterial in current medical ultrasonic coupling agent and carry out the object that sterilizing reaches minimizing cross infection.
Medical ultrasonic coupling agent for bactericidal sterilization type should possess following performance characteristic: (1) is equal with the tissue velocity of sound, to guarantee the unlikely distortion of ultrasound beam shape; (2) attenuation quotient is very little, unlikely reduction signal to noise ratio, is conducive to detecting weak echo signal; (3) with tissue acoustic characteristic impedance approximately equal, to reduce reflection loss; (4) well infiltrate with both detecting head surface and skin, with thorough deaeration; (5) long period and not mummification can be kept after coating; (6) stickiness and adhesiveness is kept in a long time, to pop one's head in along the smooth and easy slippage of skin after coating; (7) not chafe, even and if long period contact does not also cause sensitivity response; (8) do not make patient dislike, namely necessary right and wrong are dirty, and outward appearance is pleasing, in water solublity, is easy to wash off; (9) have heat stability, namely adhesion does not reduce in a clinical setting and after coating on skin; (10) sound transmission ability is possessed.
Prior art be used for the couplant product of medical ultrasonic coupling agent have common are dimethyl-silicon oils, cellulose family, take carbomer as several large class such as product of polymer matrix.As used carboxymethyl cellulose, hydroxyethyl-cellulose as polymer matrix, glycerol is as wetting agent, and Chlorhexidine hydrochloride (chlorhexidine hydrochloride), poly-hexa-methylene hydrochloric acid two guanidine are as the bactericidal sterilization type couplant of antibacterial; Take carbomer as substrate, glycerol, propylene glycol are wetting agent, and triclosan is the bactericidal sterilization type couplant of antibacterial.
The medical ultrasonic coupling agent of dimethyl-silicon oils and as the couplant product of polymer matrix using carboxymethyl cellulose, hydroxyethyl-cellulose corrosiveness is existed to medical ultrasonic probe and is restricted; And using poly-hexa-methylene hydrochloric acid two guanidine as the couplant product of antibacterial, there is stronger cytotoxicity, harm is existed to human body; The coupling agent for medical use that use carbomer, glycerol, propylene glycol, triclosan are formula is the combination of the bactericidal sterilization type couplant comparing recommendation at present, but bactericidal sterilization type is on the market due to formula, there is the deficiency that drying is very fast, adhesiveness is bad, larger to skin irritation.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, provide a kind of bactericidal sterilization type couplant, this bactericidal sterilization type couplant adopts good water solubility, prepares the component of the corrosion-free effect of ultrasonic probe, can't harm and play the effect protecting probe to ultrasonic probe; This couplant using triclosan as antibacterial, methyl parahydroxybenzoate is antibacterial, in formula, realize safety, stable sterilization and antibacterial by the synergism of the two; This couplant have stickiness good, good with the compatibility of skin, have good wetting property with human body skin and ultrasonic probe, the problem that existing couplant adhesiveness is bad, drying time is too fast can be solved; The cytotoxicity of this couplant greatly reduces, safe to use; Low to the zest of skin, the component in formula with repair function can promote the reparation of injured skin simultaneously.
Technical scheme of the present invention is as follows: a kind of bactericidal sterilization type couplant, be made up of the component of following quality proportioning: Acritamer 940 0.4 ~ 0.8%, propylene glycol 8 ~ 14%, glycerol 10 ~ 17%, vitamin B5 0.08 ~ 0.12%, PVP K30 0.7 ~ 1.1%, triclosan 0.15 ~ 0.25%, methyl parahydroxybenzoate 0.15 ~ 0.25%, triethanolamine 0.6 ~ 1.0%, sodium lauryl sulphate 0.4 ~ 0.6%, purified water surplus.
Preferably, bactericidal sterilization type couplant is made up of the component of following quality proportioning: Acritamer 940 0.6%, propylene glycol 10%, glycerol 15%, vitamin B5 0.1%, PVP K30 1%, triclosan 0.2%, methyl parahydroxybenzoate 0.2%, triethanolamine 0.81%, sodium lauryl sulphate 0.5%, purified water 71.59%.
The purified water that described purified water preferably adopts two-pass reverse osmosis method to prepare.
Described propylene glycol, glycerol are food stage.
The preparation of bactericidal sterilization type couplant of the present invention adopts following concrete steps:
(1) in stainless steel and iron container, inject purified water consumption 85 ~ 90%, start blender, stir purified water at normal temperatures with the speed of 800-1000r/min;
(2) take Acritamer 940, it is slowly scattered and enters in purified water that step (1) stirring, avoid carbomer to produce cohesion, and Keep agitation is until can't see the carbomer granules of white in dispersion liquid;
(3) under room temperature, regulate mixing speed to 200 ~ 400r/min, slowly add PVP K30, stir until PVP K30 disperses completely; Continue stirring 2 ~ 4h, after leaving standstill froth breaking, obtain colloid C3, for subsequent use;
(4) purified water of separately getting 5 ~ 7% is placed in rustless steel container, takes sodium lauryl sulphate and dissolves wherein, obtain solution C 4, for subsequent use;
(5) under room temperature, vitamin B5 is dissolved in the purified water of 1 ~ 2%, stirs, obtain solution C 5, for subsequent use;
(6) get propylene glycol and be placed in rustless steel container, add triclosan and stir, then add methyl parahydroxybenzoate, stir, obtain solution C 6;
(7) triethanolamine is added in remaining purified water, stir and be cooled to room temperature, obtain solution C 7;
(8) glycerol, solution C 4, solution C 6, solution C 5, solution C 7 are slowly added in colloid C3 successively, stir with 20-30r/min rotating speed; Whipping process is avoided producing bubble, can obtain bactericidal sterilization type couplant.
Preferably, regulate mixing speed to 300r/min in described step (3); Continue the preferred 2h of mixing time.
Preferably, in step (4), the mass ratio of sodium lauryl sulphate and purified water is 1:10.
Preferably, in step (5), the mass ratio of vitamin B5 and purified water is 1:10.
Bactericidal sterilization type couplant of the present invention is preferably applied to medical supersonic technical field.
The present invention is as follows relative to the beneficial effect of prior art:
(1) the present invention adopts the triclosan of suitable concn to be antibacterial as antibacterial, methyl parahydroxybenzoate; The mechanism of triclosan sterilization is first adsorbed in bacteria cell wall, and then penetration cell wall, with the lipid in Cytoplasm, proteins react, produce irreversible denaturation, kill antibacterial, and the antifungal mechanism of methyl parahydroxybenzoate is the cell membrane of destroy microorganisms, make intracellular protein denaturation, and the activity of the respiratory enzyme system of T suppression cell and electron transmission enzyme system, both are in the present invention by producing collaborative facilitation, strengthen product sterilization and bacteriostasis property, and can all have good fungistatic effect within the scope of wider pH; Meanwhile, triclosan, methyl parahydroxybenzoate are widely used in cosmetics, cleaning product etc., such that properties of product of the present invention are stable, safety;
(2) select the ratio of suitable Acritamer 940, PVP K30, glycerol, propylene glycol in formula of the present invention, product can be made similar to the density of tissue, and the velocity of sound is close, and sound declines few; Simultaneously, PVP K30 has good histocompatibility, can make couplant and human skin and have good wellability between popping one's head in, PVP K30 also plays the adhesiveness and sliding that increase product, reduces product to the effect of the stimulation that skin brings;
(3) vitamin B5 in formula can produce hydration in skin surface, repairs injured skin, can also promote the reparation of the damage caused during ultrasound procedure;
(4) formula composition of the present invention is water-soluble substances, under suitable ratio, after ultrasound procedure, can wash away residual product like a cork, and to human non-toxic's evil, safety is high.
Detailed description of the invention
Be described in further details the present invention below by embodiment, these embodiments are only used for the present invention is described, do not limit the scope of the invention.
Embodiment 1 adopts following formula to prepare bactericidal sterilization type couplant of the present invention: each component and quality proportioning as follows: Acritamer 940 0.6%, propylene glycol 10%, glycerol 15%, vitamin B5 0.1%, PVP K30 1%, triclosan 0.2%, methyl parahydroxybenzoate 0.2%, triethanolamine 0.81%, sodium lauryl sulphate 0.5%, purified water 71.59%.
With above-mentioned formula, following steps are adopted to produce the bactericidal sterilization type couplant product of 100Kg:
(1) in rustless steel metal bucket, inject the purified water of 64.0kg, start blender, stir purified water at normal temperatures with the speed of 800-1000r/min;
(2) take 600g Acritamer 940, it is slowly scattered and enters in purified water that step (1) stirring, avoid carbomer to produce cohesion, and Keep agitation is until can't see the carbomer granules of white in dispersion liquid;
(3), under room temperature, regulate mixing speed to 300r/min, slowly add the PVP K30 of 1.0Kg, stir until PVP K30 disperses completely; Continue to stir 2h, after leaving standstill froth breaking, obtain colloid C3, for subsequent use;
(4) purified water of separately getting 5.0kg is placed in rustless steel container, takes 500g sodium lauryl sulphate and dissolves wherein, obtain solution C 4, for subsequent use;
(5) under room temperature, 100g vitamin B5 is dissolved in the purified water of 1kg, stirs, obtain solution C 5, for subsequent use;
(6) get 10.0kg propylene glycol and be placed in stainless steel cask, add 200g triclosan and stir, then add 200g methyl parahydroxybenzoate, stir, obtain solution C 6;
(7) 810g triethanolamine is added in the purified water of remaining 1.59kg, stir and be cooled to room temperature, obtain solution C 7;
(8) 15.0kg glycerol, solution C 4, solution C 6, solution C 5, solution C 7 are slowly added in colloid C3 successively, stir with 20-30r/min rotating speed; Whipping process is avoided producing bubble, obtains bactericidal sterilization type couplant semi-finished product;
(9) adopt Semi-automatic machine for feeding bottles, semi-finished product are loaded in PVC plastic flexible pipe by the weight of often propping up 12g or 20g and seals, obtain bactericidal sterilization type couplant product.
Embodiment 2 adopts following formula to prepare bactericidal sterilization type couplant of the present invention: each component and quality proportioning as follows: Acritamer 940 0.4%, propylene glycol 12%, glycerol 17%, vitamin B5 0.08%, PVP K30 0.8%, triclosan 0.15%, methyl parahydroxybenzoate 0.25%, triethanolamine 1%, sodium lauryl sulphate 0.55%, purified water surplus.
Preparation method is as follows:
(1) in stainless steel and iron, inject purified water consumption 88%, start blender, stir purified water at normal temperatures with the speed of 1000r/min;
(2) take Acritamer 940, it is slowly scattered and enters in purified water that step (1) stirring, avoid carbomer to produce cohesion, and Keep agitation is until can't see the carbomer granules of white in dispersion liquid;
(3), under room temperature, regulate mixing speed to 300r/min, slowly add PVP K30, stir until PVP K30 disperses completely; Continue to stir 3h, after leaving standstill froth breaking, obtain colloid C3, for subsequent use;
(4) purified water of separately getting 6% is placed in rustless steel container, takes sodium lauryl sulphate and dissolves wherein, obtain solution C 4, for subsequent use;
(5) under room temperature, vitamin B5 is dissolved in the purified water of 2%, stirs, obtain solution C 5, for subsequent use;
(6) get propylene glycol and be placed in rustless steel container, add triclosan and stir, then add methyl parahydroxybenzoate, stir, obtain solution C 6;
(7) triethanolamine is added in remaining purified water, stir and be cooled to room temperature, obtain solution C 7;
(8) glycerol, solution C 4, solution C 6, solution C 5, solution C 7 are slowly added in colloid C3 successively, stir with 20r/min rotating speed; Whipping process is avoided producing bubble, can obtain bactericidal sterilization type couplant.
Embodiment 3 adopts following formula to prepare bactericidal sterilization type couplant of the present invention: each component and quality proportioning as follows: Acritamer 940 0.8%, propylene glycol 8%, glycerol 13%, vitamin B5 0.1%, PVP K30 0.7%, triclosan 0.22%, methyl parahydroxybenzoate 0.15%, triethanolamine 0.6%, sodium lauryl sulphate 0.5%, purified water surplus.
Preparation method is as follows:
(1) in stainless steel and iron container, inject purified water consumption 85%, start blender, stir purified water at normal temperatures with the speed of 800r/min;
(2) take Acritamer 940, it is slowly scattered and enters in purified water that step (1) stirring, avoid carbomer to produce cohesion, and Keep agitation is until can't see the carbomer granules of white in dispersion liquid;
(3), under room temperature, regulate mixing speed to 300r/min, slowly add PVP K30, stir until PVP K30 disperses completely; Continue to stir 2.5h, after leaving standstill froth breaking, obtain colloid C3, for subsequent use;
(4) purified water of separately getting 7% is placed in rustless steel container, takes sodium lauryl sulphate and dissolves wherein, obtain solution C 4, for subsequent use;
(5) under room temperature, vitamin B5 is dissolved in the purified water of 2%, stirs, obtain solution C 5, for subsequent use;
(6) get propylene glycol and be placed in rustless steel container, add triclosan and stir, then add methyl parahydroxybenzoate, stir, obtain solution C 6;
(7) triethanolamine is added in remaining purified water, stir and be cooled to room temperature, obtain solution C 7;
(8) glycerol, solution C 4, solution C 6, solution C 5, solution C 7 are slowly added in colloid C3 successively, stir with 30r/min rotating speed; Whipping process is avoided producing bubble, can obtain bactericidal sterilization type couplant.
Embodiment 4 adopts following formula to prepare bactericidal sterilization type couplant of the present invention: each component and quality proportioning as follows: Acritamer 940 0.7%, propylene glycol 14%, glycerol 10%, vitamin B5 0.12%, PVP K30 0.9%, triclosan 0.18%, methyl parahydroxybenzoate 0.18%, triethanolamine 0.7%, sodium lauryl sulphate 0.4%, purified water surplus.
Preparation method is as follows:
(1) in stainless steel and iron container, inject purified water consumption 90%, start blender, stir purified water at normal temperatures with the speed of 900r/min;
(2) take Acritamer 940, it is slowly scattered and enters in purified water that step (1) stirring, avoid carbomer to produce cohesion, and Keep agitation is until can't see the carbomer granules of white in dispersion liquid;
(3), under room temperature, regulate mixing speed to 200r/min, slowly add PVP K30, stir until PVP K30 disperses completely; Continue to stir 4h, after leaving standstill froth breaking, obtain colloid C3, for subsequent use;
(4) purified water of separately getting 5% is placed in rustless steel container, takes sodium lauryl sulphate and dissolves wherein, obtain solution C 4, for subsequent use;
(5) under room temperature, be dissolved in by vitamin B5 in the purified water of 1%, the mass ratio of vitamin B5 and purified water is 1:10, stirs, and obtains solution C 5, for subsequent use;
(6) get propylene glycol and be placed in rustless steel container, add triclosan and stir, then add methyl parahydroxybenzoate, stir, obtain solution C 6;
(7) triethanolamine is added in remaining purified water, stir and be cooled to room temperature, obtain solution C 7;
(8) glycerol, solution C 4, solution C 6, solution C 5, solution C 7 are slowly added in colloid C3 successively, stir with 30r/min rotating speed; Whipping process is avoided producing bubble, can obtain bactericidal sterilization type couplant.
Embodiment 5 adopts following formula to prepare bactericidal sterilization type couplant of the present invention: each component and quality proportioning as follows: Acritamer 940 0.6%, propylene glycol 11%, glycerol 16%, vitamin B5 0.1%, PVP K30 1.1%, triclosan 0.25%, methyl parahydroxybenzoate 0.2%, triethanolamine 0.9%, sodium lauryl sulphate 0.45%, purified water surplus.
Preparation method is as follows:
(1) in stainless steel and iron container, inject purified water consumption 86%, start blender, stir purified water at normal temperatures with the speed of 1000r/min;
(2) take Acritamer 940, it is slowly scattered and enters in purified water that step (1) stirring, avoid carbomer to produce cohesion, and Keep agitation is until can't see the carbomer granules of white in dispersion liquid;
(3), under room temperature, regulate mixing speed to 400r/min, slowly add PVP K30, stir until PVP K30 disperses completely; Continue to stir 3.5h, after leaving standstill froth breaking, obtain colloid C3, for subsequent use;
(4) purified water of separately getting 5% is placed in rustless steel container, takes sodium lauryl sulphate and dissolves wherein, obtain solution C 4, for subsequent use;
(5) under room temperature, vitamin B5 is dissolved in the purified water of 1%, stirs, obtain solution C 5, for subsequent use;
(6) get propylene glycol and be placed in rustless steel container, add triclosan and stir, then add methyl parahydroxybenzoate, stir, obtain solution C 6;
(7) triethanolamine is added in remaining purified water, stir and be cooled to room temperature, obtain solution C 7;
(8) glycerol, solution C 4, solution C 6, solution C 5, solution C 7 are slowly added in colloid C3 successively, stir with 30r/min rotating speed; Whipping process is avoided producing bubble, can obtain bactericidal sterilization type couplant.
Claims (10)
1. a bactericidal sterilization type couplant, it is characterized in that: be made up of the component of following quality proportioning: Acritamer 940 0.4 ~ 0.8%, propylene glycol 8 ~ 14%, glycerol 10 ~ 17%, vitamin B5 0.08 ~ 0.12%, PVP K30 0.7 ~ 1.1%, triclosan 0.15 ~ 0.25%, methyl parahydroxybenzoate 0.15 ~ 0.25%, triethanolamine 0.6 ~ 1.0%, sodium lauryl sulphate 0.4 ~ 0.6%, purified water surplus.
2. bactericidal sterilization type couplant according to claim 1, it is characterized in that: described bactericidal sterilization type couplant is made up of the component of following quality proportioning: Acritamer 940 0.6%, propylene glycol 10%, glycerol 15%, vitamin B5 0.1%, PVP K30 1%, triclosan 0.2%, methyl parahydroxybenzoate 0.2%, triethanolamine 0.81%, sodium lauryl sulphate 0.5%, purified water 71.59%.
3. bactericidal sterilization type couplant according to claim 1 and 2, is characterized in that: the purified water that described purified water preferably adopts two-pass reverse osmosis method to prepare.
4. bactericidal sterilization type couplant according to claim 1 and 2, is characterized in that: described propylene glycol, glycerol are food stage.
5. bactericidal sterilization type couplant according to claim 1 and 2, is characterized in that: described bactericidal sterilization type couplant is applied to medical supersonic.
6. a preparation method for bactericidal sterilization type couplant according to claim 1, is characterized in that: adopt following concrete steps:
(1) in stainless steel and iron container, inject purified water consumption 85 ~ 90%, start blender, stir purified water at normal temperatures with the speed of 800-1000r/min;
(2) get Acritamer 940, it is slowly scattered and enters in purified water that step (1) stirring, avoid carbomer to produce cohesion, and Keep agitation is until can't see the carbomer granules of white in dispersion liquid;
(3) under room temperature, regulate mixing speed to 200 ~ 400r/min, slowly add PVP K30, stir until PVP K30 disperses completely; Continue stirring 2 ~ 4h, after leaving standstill froth breaking, obtain colloid C3, for subsequent use;
(4) purified water of separately getting 5 ~ 7% is placed in rustless steel container, takes sodium lauryl sulphate and dissolves wherein, obtain solution C 4, for subsequent use;
(5) under room temperature, vitamin B5 is dissolved in the purified water of 1 ~ 2%, stirs, obtain solution C 5, for subsequent use;
(6) get propylene glycol and be placed in rustless steel container, add triclosan and stir, then add methyl parahydroxybenzoate, stir, obtain solution C 6;
(7) triethanolamine is added in remaining purified water, stir and be cooled to room temperature, obtain solution C 7;
(8) glycerol, solution C 4, solution C 6, solution C 5, solution C 7 are slowly added in colloid C3 successively, stir with 20-30r/min rotating speed; Whipping process is avoided producing bubble, can obtain bactericidal sterilization type couplant.
7. the preparation method of bactericidal sterilization type couplant according to claim 6, is characterized in that: regulate mixing speed to 300r/min in described step (3).
8. the preparation method of bactericidal sterilization type couplant according to claim 6, is characterized in that: continue in described step (3) to stir 2h.
9. the preparation method of bactericidal sterilization type couplant according to claim 6, is characterized in that: in described step (4), the mass ratio of sodium lauryl sulphate and purified water is 1:10.
10. the preparation method of bactericidal sterilization type couplant according to claim 6, is characterized in that: in described step (5), the mass ratio of vitamin B5 and purified water is 1:10.
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| CN109675067A (en) * | 2019-02-26 | 2019-04-26 | 山东科宏医疗科技有限公司 | A kind of medical sterilization ultrasonic coupling agent and preparation method thereof |
| CN112741671A (en) * | 2019-10-29 | 2021-05-04 | 王强 | Energy-guiding liquid for extracorporeal shock wave lithotripsy and preparation method thereof |
| CN114053440A (en) * | 2021-10-09 | 2022-02-18 | 山东消博士消毒科技股份有限公司 | Medical disinfection ultrasonic coupling agent and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107318887A (en) * | 2017-08-22 | 2017-11-07 | 马鞍山中粮生物化学有限公司 | A kind of chemosterilant and its compound method |
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