CN112741671A - Energy-guiding liquid for extracorporeal shock wave lithotripsy and preparation method thereof - Google Patents

Energy-guiding liquid for extracorporeal shock wave lithotripsy and preparation method thereof Download PDF

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Publication number
CN112741671A
CN112741671A CN201911038984.1A CN201911038984A CN112741671A CN 112741671 A CN112741671 A CN 112741671A CN 201911038984 A CN201911038984 A CN 201911038984A CN 112741671 A CN112741671 A CN 112741671A
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China
Prior art keywords
energy
shock wave
percent
acid
wave lithotripsy
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CN201911038984.1A
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Chinese (zh)
Inventor
赵霓兵
王强
缪建岭
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • A61B2017/2253—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient using a coupling gel or liquid

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention relates to an energy-guiding liquid, in particular to an energy-guiding liquid for extracorporeal shock wave lithotripsy and a preparation method thereof, and belongs to the field of medical instruments. The paint comprises the following components in percentage by mass: 1 to 15 percent of organic solvent, 0.05 to 1 percent of electrolyte, 0.05 to 1 percent of defoaming agent, 0.1 to 0.5 percent of metal ion chelating agent, 0.5 to 1 percent of viscosity regulator and deionized water. The invention aims to overcome the defects of the existing treatment technology for lithotripsy of urinary system calculus by using external shock waves, and provides the shock wave energy guiding liquid which is stable in property, safe and reliable and convenient to prepare. The problem that the energy of the shock wave is easy to lose in the common water quality conduction, and the focusing capacity is reduced after aging, so that some side reactions can occur in the treatment or after the treatment is solved.

Description

Energy-guiding liquid for extracorporeal shock wave lithotripsy and preparation method thereof
Technical Field
The invention relates to an energy-guiding liquid, in particular to an energy-guiding liquid for extracorporeal shock wave lithotripsy and a preparation method thereof, and belongs to the field of medical instruments.
Background
The extracorporeal shock wave lithotripsy treatment technology is that shock wave from lithotripsy machine is focused and transmitted to stone via the contact between skin and the lithotripsy machine to break stone into pieces. The crushed stones can be naturally discharged from the urine. The extracorporeal shock wave stone breaking method is that shock wave produces pressure stress (front stone interface) and tensile stress (back stone interface) in the interface of two kinds of propagation medium with different acoustic impedances to make stone stripped and broken gradually from the surface, so that large stone incapable of being discharged is broken into fragments capable of being discharged automatically and then discharged with urine via the urinary system. The generation of the shock wave is realized by high voltage electricity, large current and instantaneous direct current discharge. During instantaneous discharge, the discharge channel expands rapidly to form pressure pulse called shock wave in water medium, the shock wave is focused by a special reflector, the energy density at the focus can be increased by 200-300 times, and the aim of breaking stone can be achieved by placing the stone at the focus. The propagation characteristic of the shock wave is close to that of the sound wave, and the acoustic impedance of various media is greatly different due to different densities of the various media. The acoustic impedance of water is much greater than that of air, so the shock wave in water is almost completely reflected at the interface of water and air. Human tissue has more water content and acoustic impedance close to water, so that the human body needs to be completely soaked in water or a water sac is used as a propagation medium when the external shock wave is used for lithotripsy. At present, the water for the external shock wave crushed stone is tap water or distilled water mostly, the ionization degree and the viscosity of the water have no standard, and the external shock wave crushed stone is easy to age after passing through for many times, so that the effect of the crushed stone cannot be guaranteed. The shock wave is easy to lose energy in common water quality conduction, and the reduction of the focusing capacity after aging can also cause some side effects in or after treatment. Hematuria, angina, fever, hematochezia, kidney essence damage, etc. appear.
Disclosure of Invention
The invention aims to overcome the defects of the existing external shock wave lithotripsy treatment technology and provide the shock wave energy guide liquid which has stable properties, safety, reliability and convenient manufacture.
In order to achieve the purpose, the energy guiding liquid for the extracorporeal shock wave lithotripsy, which is disclosed by the invention, comprises the following components in percentage by mass: 1 to 15 percent of organic solvent, 0.05 to 1 percent of electrolyte, 0.05 to 1 percent of defoaming agent, 0.1 to 0.5 percent of metal ion chelating agent, 0.5 to 1 percent of viscosity regulator and deionized water.
The preparation method comprises the step of stirring and mixing all the components uniformly to obtain the energy dielectric fluid for the extracorporeal shock wave lithotripsy.
Further, the organic solvent is one or more of water-miscible organic substances such as methanol, ethanol, isopropanol, propylene glycol, glycerol, acetone, ethyl acetate, butyl acetate, dimethyl fumarate, and dimethylacetamide.
Further, the electrolyte is one or more of sodium chloride, potassium chloride, magnesium sulfate, sodium nitrate and potassium nitrate.
Further, the defoaming agent is one or more of emulsified silicone oil, a higher alcohol fatty acid ester compound, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether, polyoxypropylene polyoxyethylene glycerol ether and polydimethylsiloxane.
Further, the metal ion chelating agent is one or more of Ethylene Diamine Tetraacetic Acid (EDTA), Citric Acid (CA), Tartaric Acid (TA) and Gluconic Acid (GA), Hydroxyethyl Ethylene Diamine Triacetic Acid (HEDTA) and dihydroxyethyl glycine (DEG), polyacrylic acid, polymethacrylic acid, hydrolyzed polymaleic anhydride, fumaric acid (fumaric acid) -propylene sulfonic acid copolymer.
Further, the viscosity regulator is one or more of sodium carboxymethyl cellulose or synthetic high molecular compounds such as polyvinyl alcohol and acrylic acid polymer.
The invention has the following beneficial effects:
1) the process is simple and only needs physical mixing.
2) The invention has specific ionization degree and viscosity, acoustic impedance close to that of human body, small energy attenuation and high focusing performance.
3) Has no toxicity or irritation to human body.
4) Has good aging resistance and stability.
5) Has no corrosion and damage to the stone crusher.
Detailed description of the invention
The present invention will be described in detail with reference to examples, which are given for illustrative purposes only and do not limit the scope of the present invention, and other components, which are notified to those skilled in the art, may be added to the present invention if necessary, or other advantageous components may be added thereto.
Example 1
The energy medium liquid for extracorporeal shock wave lithotripsy comprises the following components in parts by weight: 5% of ethanol, 2% of glycerol, 0.05% of potassium chloride, 0.05% of emulsified silicone oil, 0.2% of Ethylene Diamine Tetraacetic Acid (EDTA), 0.5% of sodium carboxymethyl cellulose and deionized water.
The preparation method of the energy guiding liquid for the extracorporeal shock wave lithotripsy comprises the following steps: putting the components into a reaction kettle, and stirring and mixing uniformly.
Example 2
The energy medium liquid for extracorporeal shock wave lithotripsy comprises the following components in parts by weight: 5% of ethylene glycol, 0.1% of sodium chloride, 0.05% of polyoxyethylene polyoxypropylene amine ether, 0.3% of Citric Acid (CA), 0.5% of polyvinyl alcohol and deionized water.
The preparation method of the energy guiding liquid for the extracorporeal shock wave lithotripsy comprises the following steps: putting the components into a reaction kettle, and stirring and mixing uniformly.
The renal injuries in the extracorporeal shock wave lithotripsy of the energy-mediating liquid for extracorporeal shock wave lithotripsy of example 1 obtained in the present invention and distilled water were compared as follows:
examination of B-ultrasonic before and after treatment of apparent kidney stone
Figure 626843DEST_PATH_IMAGE001
The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and all simple modifications, equivalent changes and modifications made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.

Claims (8)

1. The energy-guiding liquid for the extracorporeal shock wave lithotripsy is characterized by comprising the following components in percentage by mass: 1 to 15 percent of organic solvent, 0.05 to 1 percent of electrolyte, 0.05 to 1 percent of defoaming agent, 0.1 to 0.5 percent of metal ion chelating agent, 0.5 to 1 percent of viscosity regulator and deionized water.
2. The energy mediator for extracorporeal shock wave lithotripsy according to claim 1, wherein the organic solvent is one or more of water-miscible organic substances such as methanol, ethanol, isopropanol, propylene glycol, glycerol, acetone, ethyl acetate, butyl acetate, dimethyl fumarate, and dimethylacetamide.
3. The energy-mediating fluid for extracorporeal shock wave lithotripsy according to claim 1, wherein the electrolyte is one or more of sodium chloride, potassium chloride, magnesium sulfate, sodium nitrate, and potassium nitrate.
4. The energy-mediating fluid for external shock wave lithotripsy according to claim 1, wherein the defoaming agent is one or more of silicone emulsion, higher alcohol fatty acid ester complex, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether, polyoxypropylene polyoxyethylene glycerol ether, and polydimethylsiloxane.
5. The energy-mediating fluid for extracorporeal shock wave lithotripsy according to claim 1, wherein the metal ion chelating agent is one or more of ethylenediaminetetraacetic acid (EDTA), Citric Acid (CA), Tartaric Acid (TA), and Gluconic Acid (GA), hydroxyethylethylenediaminetriacetic acid (HEDTA), and Dihydroxyethylglycine (DEG), polyacrylic acid, polymethacrylic acid, hydrolyzed polymaleic anhydride, fumaric acid (fumaric acid) -propylene sulfonic acid copolymer.
6. The energy-mediating fluid for extracorporeal shock wave lithotripsy according to claim 1, wherein the viscosity modifier is one or more of sodium carboxymethyl cellulose or a synthetic high molecular compound such as polyvinyl alcohol and an acrylic acid polymer.
7. The method for preparing the energy-mediating liquid for external shock wave lithotripsy according to claims 1 to 6, wherein the method comprises mixing and stirring the components uniformly.
8. The use method of the energy-mediating liquid for extracorporeal shock wave lithotripsy according to claims 1 to 6, wherein the energy-mediating liquid is pre-packaged and filled in water bags of various extracorporeal shock wave lithotripsy machines.
CN201911038984.1A 2019-10-29 2019-10-29 Energy-guiding liquid for extracorporeal shock wave lithotripsy and preparation method thereof Pending CN112741671A (en)

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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1422669A (en) * 2002-12-16 2003-06-11 刘晖 B-type supersonic resetting image intensifying agent for entembole and preparation technology thereof
EP1956369A2 (en) * 2007-02-08 2008-08-13 Hamilton Bonaduz AG Nano hybrid gels as polymer electrolytes based on transesterified organosiloxanes
DE102007000800A1 (en) * 2007-10-01 2009-04-02 Beiersdorf Ag Skin pigmentation reducing method for e.g. animal, involves applying coupling medium on skin or on applicator, attaching applicator on skin, and stimulating skin by shock waves emitted by applicator
CN102085382A (en) * 2011-01-28 2011-06-08 武汉耦合医学科技有限责任公司 Special sterilizing medical ultrasound couplant for ophthalmology and preparation method thereof
WO2015027752A1 (en) * 2013-08-26 2015-03-05 长春东北师大基因工程有限公司 Antibacterial medical ultrasonic coupling agent and preparation method thereof
JP2015110771A (en) * 2013-11-07 2015-06-18 キヤノン株式会社 Method for producing contrast agent
CN105194697A (en) * 2015-11-05 2015-12-30 济宁博联生物科技有限公司 Medical ultrasonic coupling agent and preparation method thereof
CN105327369A (en) * 2015-10-26 2016-02-17 佛山市平创医疗器械科技有限公司 Sterilizing-and-disinfecting-type coupling agent and preparing method thereof
CN106692997A (en) * 2017-02-20 2017-05-24 江西宜信堂医疗科技有限公司 Sterilizing and disinfecting solid-state medical ultrasonic coupling patch and preparation method thereof
CN108778346A (en) * 2016-01-10 2018-11-09 斯迈索尼卡股份有限公司 Viscosity and the improved ultrasound gel of stability
CN109675067A (en) * 2019-02-26 2019-04-26 山东科宏医疗科技有限公司 A kind of medical sterilization ultrasonic coupling agent and preparation method thereof
CN109704808A (en) * 2018-12-30 2019-05-03 无锡柯乐新材料科技有限公司 A kind of novel stone matter modification agent and preparation method thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1422669A (en) * 2002-12-16 2003-06-11 刘晖 B-type supersonic resetting image intensifying agent for entembole and preparation technology thereof
EP1956369A2 (en) * 2007-02-08 2008-08-13 Hamilton Bonaduz AG Nano hybrid gels as polymer electrolytes based on transesterified organosiloxanes
DE102007000800A1 (en) * 2007-10-01 2009-04-02 Beiersdorf Ag Skin pigmentation reducing method for e.g. animal, involves applying coupling medium on skin or on applicator, attaching applicator on skin, and stimulating skin by shock waves emitted by applicator
CN102085382A (en) * 2011-01-28 2011-06-08 武汉耦合医学科技有限责任公司 Special sterilizing medical ultrasound couplant for ophthalmology and preparation method thereof
WO2015027752A1 (en) * 2013-08-26 2015-03-05 长春东北师大基因工程有限公司 Antibacterial medical ultrasonic coupling agent and preparation method thereof
JP2015110771A (en) * 2013-11-07 2015-06-18 キヤノン株式会社 Method for producing contrast agent
CN105327369A (en) * 2015-10-26 2016-02-17 佛山市平创医疗器械科技有限公司 Sterilizing-and-disinfecting-type coupling agent and preparing method thereof
CN105194697A (en) * 2015-11-05 2015-12-30 济宁博联生物科技有限公司 Medical ultrasonic coupling agent and preparation method thereof
CN108778346A (en) * 2016-01-10 2018-11-09 斯迈索尼卡股份有限公司 Viscosity and the improved ultrasound gel of stability
CN106692997A (en) * 2017-02-20 2017-05-24 江西宜信堂医疗科技有限公司 Sterilizing and disinfecting solid-state medical ultrasonic coupling patch and preparation method thereof
CN109704808A (en) * 2018-12-30 2019-05-03 无锡柯乐新材料科技有限公司 A kind of novel stone matter modification agent and preparation method thereof
CN109675067A (en) * 2019-02-26 2019-04-26 山东科宏医疗科技有限公司 A kind of medical sterilization ultrasonic coupling agent and preparation method thereof

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