CN105536005A - Solid medical ultrasound coupling patch and preparing method thereof - Google Patents
Solid medical ultrasound coupling patch and preparing method thereof Download PDFInfo
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- CN105536005A CN105536005A CN201610005786.5A CN201610005786A CN105536005A CN 105536005 A CN105536005 A CN 105536005A CN 201610005786 A CN201610005786 A CN 201610005786A CN 105536005 A CN105536005 A CN 105536005A
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- 238000002604 ultrasonography Methods 0.000 title abstract description 12
- 239000007787 solid Substances 0.000 title abstract description 6
- 238000000034 method Methods 0.000 title abstract description 4
- 230000008878 coupling Effects 0.000 title abstract 6
- 238000010168 coupling process Methods 0.000 title abstract 6
- 238000005859 coupling reaction Methods 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 claims abstract description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 12
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920000642 polymer Polymers 0.000 claims abstract description 11
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 11
- 239000000661 sodium alginate Substances 0.000 claims abstract description 11
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 8
- 229920001525 carrageenan Polymers 0.000 claims abstract description 8
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- 239000000230 xanthan gum Substances 0.000 claims abstract description 8
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 8
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 8
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 8
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 6
- 239000000679 carrageenan Substances 0.000 claims abstract description 6
- 229940113118 carrageenan Drugs 0.000 claims abstract description 6
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 230000001225 therapeutic effect Effects 0.000 claims description 8
- 229920003091 Methocel™ Polymers 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 7
- 230000002421 anti-septic effect Effects 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 5
- 230000001788 irregular Effects 0.000 claims description 4
- CPTNXTSDQJQEFA-ZKOWQLKRSA-N mastoparan-A Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)=CNC2=C1 CPTNXTSDQJQEFA-ZKOWQLKRSA-N 0.000 claims description 4
- NSFBOCKFBVQQKB-CQWNSWRRSA-N mastoparan-B Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)=CNC2=C1 NSFBOCKFBVQQKB-CQWNSWRRSA-N 0.000 claims description 4
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims description 3
- 150000004702 methyl esters Chemical class 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 210000004872 soft tissue Anatomy 0.000 abstract description 3
- 206010011409 Cross infection Diseases 0.000 abstract description 2
- 206010029803 Nosocomial infection Diseases 0.000 abstract description 2
- 230000006870 function Effects 0.000 abstract description 2
- 210000001685 thyroid gland Anatomy 0.000 abstract description 2
- 210000004907 gland Anatomy 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 abstract 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 229960004063 propylene glycol Drugs 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000009210 therapy by ultrasound Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 description 8
- 239000000523 sample Substances 0.000 description 4
- 239000007822 coupling agent Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- 210000001715 carotid artery Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
Abstract
The invention discloses a solid medical ultrasound coupling patch and a preparing method thereof. The solid medical ultrasound coupling patch is prepared from a sodium alginate polymer, carrageenan, xanthan gum, hydroxymethyl cellulose, propylene glycol, glycerol, a preservative and deionized water. The preparing method comprises the steps that the sodium alginate polymer, glycerol, pure water and the like are taken according to the mass ratio, mixed, heated and stirred evenly, and the mixture is discharged after heat-preservation defoaming is carried out, and then form products of various specifications and shapes through filling. The solid medical ultrasound coupling patch is convenient to use and has excellent sound conduction and isolation effects; when medical personnel are in contact with infectious patients, the functions of preventing the risk of cross infection in a hospital and protecting the medical personnel are achieved after separation. The solid medical ultrasound coupling patch serves as a coupling medium, is specially applied to black and white ultrasonic equipment, color Doppler ultrasound equipment and the fields of ultrasound focusing and ultrasound treatment, and is suitable for the superficial surface, soft tissue, muscle bones, milk glands and thyroid glands of the human body and other parts where a liquid gel medium is difficult to use in ultrasound application.
Description
Technical field
The present invention relates to biomedicine technical field, a kind of solid-state medical supersonic coupled patch and preparation method thereof.
Background technology
At present, the function of medical ultrasonic coupling agent is the couplant effect be applied between ultrasonic probe and human body skin, isolated air between ultrasonic probe and examined area skin, makes acoustic transmission not decay by the impact of air, to reach good Detection results.In ultrasound field market, usually use the medical ultrasonic coupling agent product of liquid-type as the gel media used when ultrasound detection and ultrasonic therapeutic.This type of medium is water-soluble products, influenced by ambient temperaturely very easily dissolves, and brings very many troubles to difficult ultrasound detection and ultrasonic therapeutic field; And use existing liquid-type couplant just not reach desired effect for specific positions such as shallow epidermis skin tissue, soft tissue, flesh bone, carotid artery, Subcutaneous tumor, concavo-convex positions.In addition when doing long ultrasound detection and ultrasonic therapeutic, needing liquid make-up ultrasonic coupling agent continuously, to medical personnel, bringing loaded down with trivial details repeated work, and affecting detection efficiency and accuracy in detection.
Summary of the invention
The object of the present invention is to provide a kind of there is the conduction of outstanding sound while also there is fillings, pull open probe and the test section distance of positions from, energy long-time and reusable solid-state medical supersonic coupled patch and preparation method thereof, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of solid-state medical supersonic coupled patch, consist of the following composition by mass percentage: sodium alginate polymer 1.0% ~ 6.0%, carrageenan 1.0% ~ 5.0%, xanthan gum 0.03% ~ 0.05%, hydroxy methocel 0.1% ~ 0.8%, propylene glycol 2.0% ~ 15%, glycerol 2.0% ~ 15%, antiseptic 0.01% ~ 0.12%, surplus is deionized water.
A preparation method for solid-state medical supersonic coupled patch, is made up of following steps:
(1) get sodium alginate polymer by mass percentage, carrageenan, xanthan gum, hydroxy methocel, propylene glycol, glycerol mix homogeneously make mixture;
(2) by quality proportioning, the mixture in step (1) is supplemented that deionized water reaches finished fluid quality 99.88% ~ 99.99%, and again stir, form liquid mixture;
(3) liquid mixture in step (2) is put into the mulser heated and stirred 30min of preheating, make emulsion;
(4) in step (3) emulsion, add 0.01% ~ 0.12% antiseptic, and stir, make finished fluid;
(5) by the finished fluid insulation froth breaking 5 ~ 30min in step (4);
(6) by the finished fluid discharging in step (5), fill.
As the further scheme of the present invention: the mass percent of described sodium alginate polymer is 3.0%.
As the further scheme of the present invention: described antiseptic is mixture or the Kazon of methyl ester and propyl ester.
As the further scheme of the present invention: the mulser heating-up temperature in described step (3) is 50 ~ 100 DEG C.
As the further scheme of the present invention: evacuation insulation froth breaking in described step (5).
As the further scheme of the present invention: the shape specification in described step (6) is stock size, the shape of B ultrasonic equipment use, specific as follows:
The circular specification of MP-A type, diameter × thickness: 90 × 8mm, 90 × 10mm, 90 × 15mm, 90 × 20mm, 100 × 10mm, 100 × 15mm, 100 × 20mm, 90 × 25mm, 20 × 2mm, 25 × 2mm, 20 × 5mm;
Irregular shape specification MP-B type: B1, B2, B3, B4, B5, B6, B7, B8, B9;
For the circular specification of supersonic focus therapeutic equipment, diameter × thickness: 200 × 4mm, 200 × 5mm, 200 × 8mm, 200 × 10mm;
Flesh bone type: the fixed solid-state medical supersonic coupled patch shape and size according to human body flesh bony site.
Above solid-state medical supersonic coupled patch shape and size, be not limited to above-mentioned.Obligee can needed for medical disciplines, by the position of ultrasonic examination, detection or treatment, carries out relative shape and size definition.
Prepared by making by manufacture method of the present invention, solid ultrasonic gel paster acoustical behavior feature scope is:
The velocity of sound (35 DEG C): 1520m/s ~ 1620m/s
Specific acoustic impedance (35 DEG C): 1.5 × 10
6pas/m ~ 1.7 × 10
6pas/m
Acoustic attenuation (35 DEG C) :≤0.05dB/ (cm ﹒ MHz)
Viscosity (25 DEG C): >=15Pa ﹒ s
PH value: 5.5 ~ 8.0
Compared with prior art, outstanding effect of the present invention is:
The present invention is when ultrasonic examination, and following classification can present image clearly:
Tissue and position have: the ultrasonic examination at the tissues such as shallow epidermal tissue, bone flesh, eye, mammary gland, thyroid, carotid artery, Subcutaneous tumor, infant head, blood vessel, soft tissue, testis, privacy places, concavo-convex position and human body sensitive part and position, detection, monitoring and supersonic therapeutic system.Its scope of application, far away more than the part that can check with other medium.
Solid-state medical supersonic coupled patch of the present invention has certain pliability, flexible, not frangibility.
Solid-state medical supersonic coupled patch of the present invention can pull open probe and the distance detecting position, avoids medical cross infection;
Solid-state medical supersonic coupled patch of the present invention can in same people same day continuously diagnosis time repeatedly multiple location use, avoid the trouble at every turn detecting material extrusion, until treat complete or invalid to abandon as medical waste afterwards.
Solid-state medical supersonic coupled patch of the present invention adds cosmetics skin-moisturizing, skin material, and make solid-state medical supersonic coupled patch have the skin-moisturizing, skin function of cosmetics concurrently, consumer is more comfortable in use, and has no adverse effects.
Solid-state medical supersonic coupled patch outward appearance of the present invention and color, have translucent, transparent and light blue.Other color can be determined according to customer demand.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the formula in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
In the embodiment of the present invention, a kind of solid-state medical supersonic coupled patch and preparation method thereof, concrete preparation process is:
Embodiment 1
(1) get 1 gram of sodium alginate polymer, 1 gram of carrageenan, 0.03 gram of xanthan gum, 0.1 gram of hydroxy methocel, 2 grams of propylene glycol, 2 grams of glycerol mix homogeneously make mixture;
(2) mixture in step (1) is supplemented deionized water 93.82 grams by quality proportioning, and again stir, form liquid mixture;
(3) liquid mixture in step (2) is put into the mulser heated and stirred 30min being preheating to 50 DEG C, make emulsion;
(4) in step (3) emulsion, add 0.05 gram calorie pine, and stir, make finished fluid;
(5) by the finished fluid insulation froth breaking 5min in step (4);
(6) by the finished fluid discharging in step (5), fill, make the circular specification of MP-A type, diameter × thickness is the circular patch of 90 × 8mm.
Embodiment 2
(1) get 3 grams of sodium alginate polymer, 2.5 grams of carrageenans, 0.04 gram of xanthan gum, 0.4 gram of hydroxy methocel, 7.5 grams of propylene glycol, 7.5 grams of glycerol mix homogeneously make mixture;
(2) mixture in step (1) is supplemented deionized water 79 grams by quality proportioning, and again stir, form liquid mixture;
(3) liquid mixture in step (2) is put into the mulser heated and stirred 30min being preheating to 75 DEG C, make emulsion;
(4) in step (3) emulsion, add 0.06 gram calorie pine, and stir, make finished fluid;
(5) by the finished fluid insulation froth breaking 15min in step (4);
(6) by the finished fluid discharging in step (5), fill, makes the B1 paster of irregular shape specification MP-B type.
Embodiment 3
(1) get 6 grams of sodium alginate polymer, 5 grams of carrageenans, 0.05 gram of xanthan gum, 0.8 gram of hydroxy methocel, 15 grams of propylene glycol, 15 grams of glycerol mix homogeneously make mixture;
(2) mixture in step (1) is supplemented deionized water 58.03 grams by quality proportioning, and again stir, form liquid mixture;
(3) liquid mixture in step (2) is put into the mulser heated and stirred 30min being preheating to 100 DEG C, make emulsion;
(4) in step (3) emulsion, add the mixture of 0.12 gram of methyl ester and propyl ester, and stir, make finished fluid;
(5) by the finished fluid insulation froth breaking 30min in step (4);
(6) by the finished fluid discharging in step (5), fill, makes the circular specification for supersonic focus therapeutic equipment, diameter × thickness: 200 × 4mm.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (7)
1. a solid-state medical supersonic coupled patch, it is characterized in that, consist of the following composition by mass percentage: sodium alginate polymer 1.0% ~ 6.0%, carrageenan 1.0% ~ 5.0%, xanthan gum 0.03% ~ 0.05%, hydroxy methocel 0.1% ~ 0.8%, propylene glycol 2.0% ~ 15%, glycerol 2.0% ~ 15%, antiseptic 0.01% ~ 0.12%, surplus is deionized water.
2. the solid-state medical supersonic coupled patch of one according to claim 1, is characterized in that, the mass percent of described sodium alginate polymer is 3.0%.
3. the solid-state medical supersonic coupled patch of one according to claim 1, is characterized in that, described antiseptic is mixture or the Kazon of methyl ester and propyl ester.
4., according to the preparation method of the arbitrary described a kind of solid-state medical supersonic coupled patch of claim 1-3, it is characterized in that, be made up of following steps:
(1) get sodium alginate polymer by mass percentage, carrageenan, xanthan gum, hydroxy methocel, propylene glycol, glycerol mix homogeneously make mixture;
(2) by quality proportioning, the mixture in step (1) is supplemented that deionized water reaches finished fluid quality 99.88% ~ 99.99%, and again stir, form liquid mixture;
(3) liquid mixture in step (2) is put into the mulser heated and stirred 30min of preheating, make emulsion;
(4) in step (3) emulsion, add 0.01% ~ 0.12% antiseptic, and stir, make finished fluid;
(5) by the finished fluid insulation froth breaking 5 ~ 30min in step (4);
(6) by the shape specification discharging on demand of the finished fluid in step (5), fill.
5. the preparation method of a kind of solid-state medical supersonic coupled patch according to claim 4, it is characterized in that, the mulser heating-up temperature in described step (3) is 50 ~ 100 DEG C.
6. the preparation method of a kind of solid-state medical supersonic coupled patch according to claim 4, is characterized in that, evacuation insulation froth breaking in described step (5).
7. the preparation method of a kind of solid-state medical supersonic coupled patch according to claim 4, it is characterized in that, shape specification in described step (6) is stock size, the shape of B ultrasonic equipment use, includes but not limited to MP-A type, irregular shape specification MP-B type, specific as follows:
The circular specification of MP-A type, diameter × thickness: 90 × 8mm, 90 × 10mm, 90 × 15mm, 90 × 20mm, 100 × 10mm, 100 × 15mm, 100 × 20mm, 90 × 25mm, 20 × 2mm, 25 × 2mm, 20 × 5mm;
Irregular shape specification MP-B type: B1, B2, B3, B4, B5, B6, B7, B8, B9;
Shape specification for supersonic focus therapeutic equipment includes but not limited to circular and flesh bone type, specific as follows:
For the circular specification of supersonic focus therapeutic equipment, diameter × thickness: 200 × 4mm, 200 × 5mm, 200 × 8mm, 200 × 10mm;
Flesh bone type: the fixed solid-state medical supersonic coupled patch shape and size according to human body flesh bony site.
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| CN201610005786.5A CN105536005B (en) | 2016-01-06 | 2016-01-06 | A kind of solid-state medical supersonic coupled patch and preparation method thereof |
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| CN105536005B CN105536005B (en) | 2018-07-13 |
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Cited By (10)
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| CN106581699A (en) * | 2016-12-30 | 2017-04-26 | 江西宜信堂医疗科技有限公司 | Bactericidal aseptic solid medical ultrasonic coupling patch and preparation method thereof |
| CN106620734A (en) * | 2016-12-20 | 2017-05-10 | 江西宜信堂医疗科技有限公司 | Sterile medical ultrasonic coupling patch and preparation method thereof |
| CN106729776A (en) * | 2016-12-20 | 2017-05-31 | 江西宜信堂医疗科技有限公司 | A kind of solid-state medical supersonic coupled patch and preparation method thereof |
| CN107412793A (en) * | 2017-07-26 | 2017-12-01 | 广州沁瀚生物科技有限公司 | A kind of biological ultrasonic coupling paster and its industrialized process for preparing |
| CN107510851A (en) * | 2017-08-31 | 2017-12-26 | 邹伟华 | A kind of medical supersonic coupling pad and preparation method thereof |
| CN109602450A (en) * | 2019-01-29 | 2019-04-12 | 北京大学第三医院（北京大学第三临床医学院） | A kind of ultrasound intracavitary probe isolation and lead sound integrated apparatus |
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| CN106729776A (en) * | 2016-12-20 | 2017-05-31 | 江西宜信堂医疗科技有限公司 | A kind of solid-state medical supersonic coupled patch and preparation method thereof |
| CN106581699A (en) * | 2016-12-30 | 2017-04-26 | 江西宜信堂医疗科技有限公司 | Bactericidal aseptic solid medical ultrasonic coupling patch and preparation method thereof |
| CN106581699B (en) * | 2016-12-30 | 2018-04-17 | 江西宜信堂医疗科技有限公司 | A kind of antibacterial type sterile solid medical supersonic coupled patch and preparation method thereof |
| CN107412793A (en) * | 2017-07-26 | 2017-12-01 | 广州沁瀚生物科技有限公司 | A kind of biological ultrasonic coupling paster and its industrialized process for preparing |
| CN107510851A (en) * | 2017-08-31 | 2017-12-26 | 邹伟华 | A kind of medical supersonic coupling pad and preparation method thereof |
| CN109602450A (en) * | 2019-01-29 | 2019-04-12 | 北京大学第三医院（北京大学第三临床医学院） | A kind of ultrasound intracavitary probe isolation and lead sound integrated apparatus |
| CN110464851A (en) * | 2019-08-20 | 2019-11-19 | 上海纳米技术及应用国家工程研究中心有限公司 | The preparation method of graphene filled-type hydrogel ultrasonic coupling patch |
| CN113230421A (en) * | 2021-04-29 | 2021-08-10 | 山东优杰生物科技有限公司 | Medical solid coupling patch and preparation method thereof |
| CN114225056A (en) * | 2021-12-28 | 2022-03-25 | 复旦大学 | Medical ultrasonic coupling patch |
| CN114748096A (en) * | 2022-04-15 | 2022-07-15 | 云南大学附属医院 | Low-cost sound guide pad suitable for superficial tissue ultrasonic examination |
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