CN107510851A - A kind of medical supersonic coupling pad and preparation method thereof - Google Patents
A kind of medical supersonic coupling pad and preparation method thereof Download PDFInfo
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- CN107510851A CN107510851A CN201710775672.3A CN201710775672A CN107510851A CN 107510851 A CN107510851 A CN 107510851A CN 201710775672 A CN201710775672 A CN 201710775672A CN 107510851 A CN107510851 A CN 107510851A
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- coupling pad
- medical supersonic
- gellan gum
- carragheen
- preservative
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- 230000008878 coupling Effects 0.000 title claims abstract description 56
- 238000010168 coupling process Methods 0.000 title claims abstract description 56
- 238000005859 coupling reaction Methods 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 53
- 241000206575 Chondrus crispus Species 0.000 claims abstract description 31
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 30
- 229920002148 Gellan gum Polymers 0.000 claims abstract description 29
- 235000010492 gellan gum Nutrition 0.000 claims abstract description 29
- 239000000216 gellan gum Substances 0.000 claims abstract description 29
- 235000011187 glycerol Nutrition 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 26
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims abstract description 25
- 229920002581 Glucomannan Polymers 0.000 claims abstract description 25
- 229940046240 glucomannan Drugs 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000003755 preservative agent Substances 0.000 claims description 27
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- 239000008367 deionised water Substances 0.000 claims description 15
- 229910021641 deionized water Inorganic materials 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 4
- QYYMDNHUJFIDDQ-UHFFFAOYSA-N 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one Chemical group CN1SC=CC1=O.CN1SC(Cl)=CC1=O QYYMDNHUJFIDDQ-UHFFFAOYSA-N 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical class COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- 238000007872 degassing Methods 0.000 claims description 2
- 238000009413 insulation Methods 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract description 14
- 235000010413 sodium alginate Nutrition 0.000 abstract description 13
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- 239000001257 hydrogen Substances 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 6
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- 229920001661 Chitosan Polymers 0.000 description 2
- 229920002752 Konjac Polymers 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
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- 206010011409 Cross infection Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- 206010021703 Indifference Diseases 0.000 description 1
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- 244000275012 Sesbania cannabina Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
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- 210000001188 articular cartilage Anatomy 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
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- 239000002537 cosmetic Substances 0.000 description 1
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- 230000003013 cytotoxicity Effects 0.000 description 1
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- 238000006731 degradation reaction Methods 0.000 description 1
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- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
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- 238000005342 ion exchange Methods 0.000 description 1
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- 239000000252 konjac Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The invention discloses a kind of coupling of medical supersonic to pad, its composition composition includes Glucomannan, xanthans, carragheen, gellan gum, glycerine etc., to solve the problems, such as sodium alginate gel system stability deficiency in existing coupling pad, and there is good biocompatibility, sound translative performance and mechanical strength simultaneously, surface is smooth, with rear noresidue, the characteristics of pH value is neutral and long-time stability are good.Present invention also offers a kind of preparation method of medical supersonic coupling pad.
Description
Technical field
The present invention relates to medical material tech field, and in particular to a kind of medical supersonic coupling pad and preparation method thereof.
Background technology
In ultrasonic examination or therapeutic process, popping one's head in, it is super to be needed to use between (or treatment head) radiating surface and skin-mucous membrane
Acoustic couplant carries out air exclusion, to reduce decay of the ultrasonic wave during penetrating.When checking some superficial tissues,
To overcome blind area (when carrying out ultrasonic scan, the region close from probe radiating surface, to be folded due to good sound wave can not be formed
Add, so echo-signal is weaker, the picture quality of generation lacks clinical diagnosis meaning, and in ultrasound field, this distance is referred to as blind
Area, unit：Mm the influence of picture quality caused by), probe need to be left skin-mucous membrane a certain distance, to obtain well
Picture quality.Ordinary ultrasonic couplant is pasty state hydrogel, it is impossible to meets this requirement.
For such a situation, at present using ultrasonic coupling pad (the hydrogel elastic body of sheet) in probe (or treatment
Head) air exclusion is carried out between skin-mucous membrane.In addition, when being padded using ultrasonic coupling, because probe (or treatment head) directly exists
Slided on smooth coupling pad, avoid the friction popped one's head in (or treatment head) between patient skin-mucous membrane, reduce frictional force pair
The damage of layer of silica gel on (or treatment head) the ultrasonic radiation face of probe, plays a part of protection probe (or treatment head).Using ultrasound
Coupling pad carries out ultrasonic examination or treatment, can also realize the probability disposable, reduction doctor's cross infection in hospital occurs.Together
When, using ultrasonic coupling pad carry out ultrasonic examination or treatment when, remain in patient lubricant (typically by water, propane diols,
Glycerine etc. forms) easily erasing, stain will not be also remained on clothing even if spontaneously drying, it is easy to use.
Publication No. CN 105536005A Chinese patent literature disclose a kind of solid-state medical supersonic coupled patch and its
Preparation method, the ultrasonic coupling paster consist of the following composition by mass percentage：Sodium alginate polymer 1.0%~6.0%,
Carragheen 1.0%~5.0%, xanthans 0.03%~0.05%, hydroxymethyl cellulose 0.1%~0.8%, propane diols 2.0%
~15%, glycerine 2.0%~15%, preservative 0.01%~0.12%, surplus are deionized water.
The technical scheme, can when running into certain density calcium ion with sodium alginate using sodium alginate as main synthetic material
Rapid generation ion exchange formation gel is general principle to carry out.Sodium alginate is the polysaccharide extracted using brown alga as raw material
Foodstuff glue, in finite concentration polyvalent cation (such as Ca2+、Cu2+Deng) it is existing under the conditions of, can after the heated cooling of sodium alginate
Form gel.Ca2+In the formation mechenism for inducing sodium alginate gel, egg carton model is widely accepted, i.e., in Ca2+Existing bar
Under part, after G units content reaches certain value in sodium alginate, it mainly will exist with double-spiral structure, and the Gu in G units
Sieve aldehydic acid is arranged with the cavity of the negative electrical charge of band one, Egg tray structure is formed, when sodium alginate and Ca2+During interaction, Ca2+
Just polymer gel is first combined to form with the G units with Egg tray structure.
The weak point of the technical scheme essentially consists in：, can when sodium alginate gel system is used as ultrasonic examination or treatment
Picture quality can be influenceed because mechanical effect, cavitation effect and the fuel factor of ultrasonic wave cause the generation of degraded, glue be present
Body stability risk.Correlative study report includes：Sodium alginate soln is in the presence of power ultrasonic, even low-power
Scope also can occur obvious cavitation effect and degrade, while produces free radical and (Zhao Jianjun, in sea, Zhu Guangjun, Yu Jiangang, surpass
Degradation reaction research [journal article]-spectrographic laboratory 2009.26 (2) of the method for acoustic for sodium alginate)；And alginic acid
After sodium solution is subjected to the heat treatment of different time, solution layering, anisotropy and viscosity etc. can occur systematicness change (left Ju,
Ma Xian, Ji Ang, research [journal article]-Nankai University's journal (natural science) 1995.28 (3) of sodium alginate heat endurance)
Deng.
In addition, to disclose a kind of disinfection sterilizing type solid-state medical for the A of Publication No. CN 106692997 Chinese patent literature
Ultrasonic coupling paster and preparation method thereof, it uses carragheen, modified bletilla polysaccharide and carboxymethyl chitosan to make gel.
The A of Publication No. CN 106581699 Chinese patent literature discloses a kind of antibacterial type sterile solid medical supersonic
Coupled patch and preparation method thereof, it uses modified bletilla polysaccharide and carboxymethyl chitosan to make gel.
The A of Publication No. CN 106729776 Chinese patent literature disclose a kind of solid-state medical supersonic coupled patch and
Its preparation method, it uses acrylic acid-acrylic acid butyl ester-styrol copolymer and modified sesbania gum to make aqueous high molecular and coagulate
Glue.
Existing ultrasonic coupling pad or patch products are in biocompatibility, sound translative performance, mechanical strength, surface flatness and profit
Slippery, with rear residual and long-time stability etc. it cannot concurrently reach desirable.
The content of the invention
It is an object of the invention to provide a kind of brand-new medical supersonic coupling pad technical scheme, to solve existing coupling
In pad the problem of sodium alginate gel system stability deficiency, and there is good biocompatibility, sound translative performance and power simultaneously
Intensity is learned, surface is smooth, with rear noresidue, the characteristics of pH value is neutral and long-time stability are good.Present invention also offers one kind
The preparation method of medical supersonic coupling pad.
To achieve the above object, one aspect of the invention provides a kind of medical supersonic coupling pad, the medical supersonic coupling
Pad is closed to consist of the following composition：Glucomannan, xanthans, carragheen, gellan gum, glycerine, preservative, pH nertralizers and deionization
Water.
Further, the medical supersonic coupling pad consists of the following composition by weight percentage：Glucomannan 0.3%~
3.0%th, xanthans 0.05%~1.0%, carragheen 0.5%~3.0%, gellan gum 0.01%~1.0%, glycerine 2.0%~
10%th, preservative 0.02%~0.15%, pH nertralizers 0.06%~0.30%, surplus are deionized water.
Preferably, the medical supersonic coupling pad consists of the following composition by weight percentage：Glucomannan 0.6%~
2.4%th, xanthans 0.1%~0.8%, carragheen 0.8%~2.5%, gellan gum 0.1%~0.7%, glycerine 4.6%~
8.5%th, preservative 0.03%~0.08%, pH nertralizers 0.08%~0.20%, surplus are deionized water.
In a further preferred embodiment, the medical supersonic coupling pad is by weight percentage by following component group
Into：Glucomannan 0.6%~0.8%, xanthans 0.3%~0.4%, carragheen 0.8%~1.0%, gellan gum 0.1%~
0.2%th, glycerine 5.0%~8.0%, preservative 0.03%~0.05%, pH nertralizers 0.09%~0.15%, surplus for go from
Sub- water.
In another further preferred embodiment, the medical supersonic coupling pad is by weight percentage by following component group
Into：Glucomannan 1.2%~2.0%, xanthans 0.4%~0.6%, carragheen 1.4%~2.0%, gellan gum 0.2%~
0.5%th, glycerine 6.2%~8.2%, preservative 0.05%~0.06%, pH nertralizers 0.12%~0.18%, surplus for go from
Sub- water.
It is main synthesis material with Glucomannan (Konjac Glucomannan, abbreviation KGM) in technical solution of the present invention
Material.Glucomannan is a kind of water-soluble nonionic polysaccharide that extraction is processed further on the basis of konjaku powder, by molecule
Than 1:1.6 glucose and mannose residue is polymerized by β-Isosorbide-5-Nitrae glycosidic bond, on some saccharide residue C-3 positions there is
With β -1, the side chain of 3 glycosidic bonds composition, there is 1 side chain on every 32~80 saccharide residues on main chain, have on every side chain several
To tens saccharide residues, every about there is an acetyl group combined with ester bond on 19 saccharide residues on main chain.
Structure unique KGM, determines that it has a variety of unique physicochemical properties：1) water-soluble and water-retaining property：KGM molecules
In containing the hydrophilic radical such as great amount of hydroxy group, carbonyl, it can combine large quantity of moisture, by hydrogen bond, molecular dipole, induced dipole,
The active forces such as transient dipole and water molecules form the giant molecule for being difficult to free movement, by this network structure, KGM's
Moisture-holding capacity can reach 100~200 times of its own weight.2) thickening property：KGM has good thickening property, and molecular weight is about
200000~2,000,000 dalton, the viscosity of the 1% concentration KGM aqueous solution is i.e. up to 5000~40000mPas, in all natural increasings
Viscosity highest in thick dose.3) gelling：KGM and xanthans, carragheen etc. mix, and there is strong gel to act synergistically；With OK a karaoke club
When glue compounds, KGM shows as gel toughness, and carragheen shows as gel fragility.For technical solution of the present invention, more preferably
The molecular weight of used Glucomannan is 1,000,000~2,000,000 dalton.In technical solution of the present invention, the weight of Glucomannan
It is 0.3%~3.0% to measure percentage, and when Glucomannan is less than 0.3%, KGM cooperates with work with the gel of xanthans, carragheen etc.
With substantially reducing, elasticity and toughness decline, and ultrasonic coupling pad is easy to rupture, it is difficult to meets Clinical practice requirement；When KGM is dense
When degree is higher than 3.0%, due to KGM high viscosity, cause that total gum concentration is excessive, and solution is feeding-up, other compositions dissolvings are not in system
It is good.
The principle of KGM compounding collaborations：KGM is by its special long-chain Double-helical molecule structure and intramolecular, intermolecular
Hydrogen bond forms the essential structure of film.It is blended in film forming procedure, with other filmogens by hydrogen bond intermolecular phase interaction occurs for KGM
With forming stable three-dimensional space network structure.In cooling procedure, blended liquid molecular structure initial representation is irregular, and
Neat layer structure is slowly formed, ultimately forms the network structure of densification.When KGM and carragheen compound, viscosity of mixed liquid with
The rise of temperature and reduce, when reaching critical point, by intermolecular reciprocation, secondary key and interchain Cross Trade around structure
Into the three-dimensional space network structure of complexity, make KGM- carragheens composite membrane that there is very high mechanical strength (to show as good resist
Tensile strength, fracture elongation and rational modulus of elasticity).Meanwhile KGM- carragheen structure of composite membrane is close, carragheen can be reduced
The generation of excreting water phenomenon during exclusive use.In technical solution of the present invention, the percentage by weight of carragheen is 0.5%~3.0%,
When carrageenan concentrations are less than 0.5%, the film forming of carragheen and KGM, xanthans is very poor, and mechanical strength deficiency is (main after gel
Show as consistency and elasticity decline)；When carrageenan concentrations are higher than 3.0%, show as that gel hardness is excessive, and fragility is excessive,
It is unfavorable for carrying out air exclusion on human body male and fomale(M＆F), and gel is easily broken.
In the technical program, xanthans plays synergy synergy.From the point of view of experimental result, xanthans is added in system
Afterwards, the toughness of colloid, tensile strength are greatly improved.In technical solution of the present invention, the weight percent of xanthans
Than for 0.05%~1.0%, when xanthan gum concentration is less than 0.05%, couple pad toughness and tensile strength can under
Drop；When xanthan gum concentration is higher than 1.0%, it can cause that total gum concentration is excessive, and system is feeding-up, influence the dissolving of other compositions.And
It is main in system to play synergy and xanthans oneself is unable to gel, there is most suitable amount ratio with KGM, carragheen
Example, changing usage ratio can cause gel strength to decline on the contrary.
Glycerine has plasticizer and lubricant in this gel rubber system, can be with as hydrophilic plasticizer glycerine
KGM forms hydrogen bond, and this hydrogen bond is more readily formed than KGM intramolecular or intermolecular hydrogen bond.Therefore, plasticizer glycerine is added
Afterwards, original hydrogen bond will be broken, and form renewal, stronger hydrogen bond, thus can be reduced the modulus of elasticity of composite membrane and be resisted
Tensile strength, increase elongation at break.In addition, the strong moisture pick-up properties of plasticizer can enter one moisture absorption to KGM systems
Step reduces the excreting water phenomenon of colloid.In technical solution of the present invention, the percentage by weight of glycerine is 2.0%~10%, works as glycerine
When concentration is less than 2.0%, coupling pad surface liquid fraction content is less, lubricity deficiency, is unfavorable for reducing gel mat surface
Frictional force；When glycerine is higher than 10%, it is too small to couple the modulus of elasticity of pad, and shape retentivity is deteriorated.
The gellan gum used in the technical program is preferably low-acyl gellan gum.Add gellan gum except with xanthans, card
Glue is drawn to be acted synergistically, outside the toughness for further improving colloid, gellan gum can be additionally used in the hardness for adjusting colloid, reduce probe
The gas that the frictional force and expeling that (or treatment head) moves in colloid surface are remained in skin-mucous membrane pore.In skill of the present invention
In art scheme, the percentage by weight of gellan gum is 0.01%~1.0%, and when gellan gum concentration is less than 0.01%, colloid coagulates
Glue synergy performance unobvious；When gellan gum concentration is higher than 1.0%, even if concentration is high again, to the regulating power of hardness
It will not strengthen, main cause is without addition Ca in system2+、Mg2+Deng bivalent cation, the gel strength of gellan gum depends on
The concentration of system cationic.
In technical solution of the present invention, used preservative can be typically used in medicine, foods and cosmetics field
Preservative, such as Kathon CG, nipagin esters etc..Its performance and application method are well known to those skilled in the art.Skill of the present invention
The percentage by weight of preservative in art scheme is 0.02%~0.15%, and when concentration of preservatives is less than 0.02%, sterilization is anti-
Rotten effect is bad；When concentration of preservatives is higher than 0.2%, easily causes biocompatibility risk, particularly cytotoxicity, stimulate
With sensitization equivalent risk.
In technical solution of the present invention, the pH value that used preservative is dissolved in water is generally less than 7, such as Preservative Kathon CG(Methylchloroisothiazolinone/Methylisothiazolinone combination) is molten
It is 2~5 in the pH value of water, the pH value that nipagin esters are dissolved in water is 4~7.In ensuring that the acid-base value of inventive gel system is
Property, it is necessary to add usually used alkalescent pH nertralizers in pH nertralizers, such as common couplant in system.It is non-at one
In limited embodiment, the pH nertralizers are triethanolamine.
Another aspect of the present invention additionally provides the preparation method of above-mentioned medical supersonic coupling pad, the preparation method bag
Include following step：
1) Glucomannan, xanthans, carragheen and gellan gum are taken respectively by mass percentage, and is well mixed and mixing is made
Thing；
2) deionized water by mass percentage, is added in reaction vessel；
3) reaction vessel is put into and be pre-heated in 60 DEG C of constant temperature water tank；
4) under stirring, it is slowly added to the mixture of step 1) preparation；
5) mixture is heated to 100 DEG C under stirring, after being kept for 5~10 minutes, Temperature fall is to protecting after 80 DEG C
Hold constant temperature；
6) under temperature constant state, glycerine, preservative and pH nertralizers are added, after stirring, is pressed with -40KPa~-90KPa
Power deaerates 10~30 minutes；
8) after the completion of deaerating, the hydrosol of acquisition is poured into mould；
9) 4~6 hours are stood at room temperature, completes to pack after solidifying and dispatch from the factory.
Further, insulation starts to cool after 6~8 minutes in step 5).
Further, degassing pressure is -60KPa~-70KPa in step 6).
The ultrasonic coupling pad of the present invention can produce different shaping and the gel of size according to the difference of perfusion mold shape
Pad.According to the difference using position in terms of specification, general point following several：
Superficial tissues (position such as thyroid gland, mammary gland, articular cartilage, limb vessel and skin layer focus) (diameter * thickness)：
90mm*2.0mm、90mm*3.0mm、115mm*2.0mm、115mm*3.0mm、140mm*2.0mm、140mm*3.0mm、155mm*
2.0mm and 155mm*3.0mm etc..
For other positions outside superficial tissues, for example, belly or other have the position of special requirement, can be customized according to need.
The present invention program has the following advantages that compared with prior art：
1st, used main material is wholefood glue, has good biocompatibility, no cytotoxicity, to skin
Skin-mucous membrane is without sensitization, nonirritant.
2nd, gel acoustical behavior is good, and sample send " ultrasonic medical National Engineering Research Centre " to be tested, main sound
Performance indications are learned to meet《Medical ultrasonic coupling agent YY 0299-2008》Requirement；Sample has carried out small quantities of measurement in multiple hospitals
Examination, stable image quality, image definition is with using both common couplant indifferences (see Fig. 1, Fig. 2).
3rd, colloid has very strong toughness, even if thickness accomplishes 2.0MM, also can bear very big pressure and it is not broken (see
Fig. 3), avoid due to causing the rupture of coupling pad (during Clinical practice, finding interest region, but image matter when pressing is popped one's head in
When amount is not very clear or needs to distinguish dynamic/vein blood vessel in superficial tissues, it usually needs using pressing at an angle
The method for pressing probe, this is the needs to get a distinct image, and the use habit of many clinicians)；It is appropriate to have simultaneously
Elasticity, be advantageous to the coupling between probe and skin-mucous membrane, exclude the air that remains on contact surface, obtain good image
Quality.
4th, surface is smooth, is advantageous to probe (or treatment head) and slides scanning on skin-mucous membrane, advantageously reduces frictional force
Damage to layer of silica gel in probe radiating surface.
5th, after the completion of the use of coupling pad, the noresidue gel on patient skin-mucous membrane.
6th, gel pH is neutral, and stability is good, and after being placed 120 days in 40 degrees Celsius of insulating box, colloid does not occur
Phenomena such as changing colour, be layered, be corrupt, be rotten, mechanical property does not change (see Fig. 4).After exposing 90 days to the open air in atmosphere, in colloid
Most of moisture evaporation, colloid is thinning, volume-diminished, shows that this colloid is a kind of environmental protection, degradable biological material (see figure
5)。
Brief description of the drawings
Fig. 1 shows the situation of the medical supersonic coupling pad Thyreoidine inspection of the present invention.
Fig. 2 shows that the medical supersonic coupling pad of the present invention is used for the ultrasound display image that pregnant woman fetus checks.
Fig. 3 shows that the medical supersonic coupling pad of 2mm thickness of the present invention presses probe to see at an angle in simulation
When examining interest region, coupling pad does not rupture.
Fig. 4 show the present invention medical supersonic coupling pad placed 120 days in 40 degree of insulating boxs after, volume, elasticity and
Toughness does not change.
Fig. 5 shows that the medical supersonic coupling pad of the present invention is exposed in air at room temperature, and after placing 90 days, diameter becomes
It is small, thickness is thinning.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Medical ultrasonic coupling pad consists of the following composition by weight percentage in the present embodiment：Glucomannan 0.6%, xanthan
Glue 0.4%, carragheen 0.8%, gellan gum 0.1%, glycerine 6.8%, preservative 0.04%, pH nertralizers 0.10%~
0.15%, surplus is deionized water.
Embodiment 2
Medical ultrasonic coupling pad consists of the following composition by weight percentage in the present embodiment：Glucomannan 0.8%, xanthan
Glue 0.4%, carragheen 1.0%, gellan gum 0.2%, glycerine 7.0%, preservative 0.05%, pH nertralizers 0.12%, surplus are
Deionized water.
Embodiment 3
Medical ultrasonic coupling pad consists of the following composition by weight percentage in the present embodiment：Glucomannan 1.5%, xanthan
Glue 0.5%, carragheen 1.6%, gellan gum 0.4%, glycerine 6.8%, preservative 0.05%, pH nertralizers 0.14%, surplus are
Deionized water.
Embodiment 4
Medical ultrasonic coupling pad consists of the following composition by weight percentage in the present embodiment：Glucomannan 1.8%, xanthan
Glue 0.6%, carragheen 1.8%, gellan gum 0.4%, glycerine 7.5%, preservative 0.06%, pH nertralizers 0.16%, surplus are
Deionized water.
Embodiment 5
Medical ultrasonic coupling pad consists of the following composition by weight percentage in the present embodiment：Glucomannan 2.0%, xanthan
Glue 0.8%, carragheen 1.2%, gellan gum 0.5%, glycerine 8.0%, preservative 0.06%, pH nertralizers 0.16%, surplus are
Deionized water.
Embodiment 6
Medical ultrasonic coupling pad consists of the following composition by weight percentage in the present embodiment：Glucomannan 2.5%, xanthan
1.0%th, carragheen 1.5%, gellan gum 0.8%, glycerine 6.0%, preservative 0.08%, pH nertralizers 0.20%, surplus are to go
Ionized water.
The medical supersonic in embodiment 1-6 is prepared by preceding method and couples pad, its specification (diameter * thickness) is respectively：
115mm*3.0mm, 140mm*3.0mm, 140mm*2.0mm, 115mm*2.0mm, 90mm*2.0mm and 155mm*3.0mm.Survey
Obtaining its every acoustics and mechanical property parameters is：
The velocity of sound (35 DEG C)：1521m/s~1604m/s
Acoustic characteristic impedance (35 DEG C)：1.58×106Pa.m/s~1.65 × 106Pa.m/s
Acoustic attenuation coefficient slope (35 DEG C)：Less than 0.05dB/ (cm ˙ MHz)
The sample prepared in embodiment 1-6, pull to diameter be about 2 times when without fracture, show good tensile property.
Although above with general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (10)
1. a kind of medical supersonic coupling pad, it is characterised in that the medical supersonic coupling pad consists of the following composition：Portugal is sweet poly-
Sugar, xanthans, carragheen, gellan gum, glycerine, preservative, pH nertralizers and deionized water.
2. medical supersonic coupling pad according to claim 1, it is characterised in that the medical supersonic coupling pad by weight hundred
Ratio is divided to consist of the following composition：Glucomannan 0.3%~3.0%, xanthans 0.05%~1.0%, carragheen 0.5%~
3.0%th, gellan gum 0.01%~1.0%, glycerine 2.0%~10%, preservative 0.02%~0.15%, pH nertralizers 0.06%
~0.30%, surplus is deionized water.
3. medical supersonic coupling pad according to claim 1, it is characterised in that the medical supersonic coupling pad by weight hundred
Ratio is divided to consist of the following composition：Glucomannan 0.6%~2.4%, xanthans 0.1%~0.8%, carragheen 0.8%~
2.5%th, gellan gum 0.1%~0.7%, glycerine 4.6%~8.5%, preservative 0.03%~0.08%, pH nertralizers 0.08%
~0.20%, surplus is deionized water.
4. medical supersonic coupling pad according to claim 1, it is characterised in that the medical supersonic coupling pad by weight hundred
Ratio is divided to consist of the following composition：Glucomannan 0.6%~0.8%, xanthans 0.3%~0.4%, carragheen 0.8%~
1.0%th, gellan gum 0.1%~0.2%, glycerine 5.0%~8.0%, preservative 0.03%~0.05%, pH nertralizers 0.09%
~0.15%, surplus is deionized water.
5. medical supersonic coupling pad according to claim 1, it is characterised in that the medical supersonic coupling pad by weight hundred
Ratio is divided to consist of the following composition：Glucomannan 1.2%~2.0%, xanthans 0.4%~0.6%, carragheen 1.4%~
2.0%th, gellan gum 0.2%~0.5%, glycerine 6.2%~8.2%, preservative 0.05%~0.06%, pH nertralizers 0.12%
~0.18%, surplus is deionized water.
6. the medical supersonic coupling pad according to any one of claim 1-5, it is characterised in that point of the Glucomannan
Son amount is 1,000,000~2,000,000 dalton；The gellan gum is low-acyl gellan gum.
7. the medical supersonic coupling pad according to any one of claim 1-5, it is characterised in that the preservative is Kathon CG
And/or nipagin esters；The pH nertralizers are triethanolamine.
8. the preparation method of the medical supersonic coupling pad according to any one of claim 1-7, it is characterised in that the side
Method comprises the following steps：
1) Glucomannan, xanthans, carragheen and gellan gum are taken respectively by mass percentage, and is well mixed and mixture is made；
2) deionized water by mass percentage, is added in reaction vessel；
3) reaction vessel is put into and be pre-heated in 60 DEG C of constant temperature water tank；
4) under stirring, it is slowly added to the mixture of step 1) preparation；
5) mixture is heated to 100 DEG C under stirring, after being kept for 5~10 minutes, Temperature fall is permanent to holding after 80 DEG C
Temperature；
6) under temperature constant state, glycerine, preservative and pH nertralizers is added, after stirring, is taken off with -40KPa~-90KPa pressure
Gas 10~30 minutes；
8) after the completion of deaerating, the hydrosol of acquisition is poured into mould；
9) 4~6 hours are stood at room temperature, completes to pack after solidifying and dispatch from the factory.
9. preparation method according to claim 8, it is characterised in that insulation starts to cool after 6~8 minutes in step 5)；
Degassing pressure is -60KPa~-70KPa in step 6).
10. preparation method according to claim 8, it is characterised in that the diameter * of prepared medical supersonic coupling pad is thick
Metric lattice are：
For superficial tissues：90mm*2.0mm、90mm*3.0mm、115mm*2.0mm、115mm*3.0mm、140mm*2.0mm、
140mm*3.0mm, 155mm*2.0mm or 155mm*3.0mm；
It is customized according to need for other positions outside superficial tissues.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114376616A (en) * | 2022-03-23 | 2022-04-22 | 聚融医疗科技(杭州)有限公司 | Acoustically transparent coupling device, preparation method thereof and mammary gland ultrasonic diagnosis equipment |
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