CN110327473B - Medical ultrasonic coupling pad powder and using method thereof - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
The invention relates to the technical field of medical materials, in particular to medical ultrasonic coupling pad powder and a using method thereof, wherein the powder comprises 12-15 parts by weight of collagen, 1-1.5 parts by weight of hectorite powder, 0.5-1.2 parts by weight of starch-based polymer and 5-10 parts by weight of pea peptide. The couplant powder provided by the invention is simple to use, can be prepared on site at present, is quick to prepare, is convenient and simple to prepare, has clear ultrasonic images, and is more convenient to transport, store and use in a capsule or bag form.
Description
Technical Field
The invention relates to the technical field of medical materials, in particular to medical ultrasonic coupling pad powder and a using method thereof.
Background
During the ultrasonic examination or treatment, the radiation surface of the probe (or the treatment head) needs to be isolated from the skin-mucosa by air by using an ultrasonic couplant so as to reduce the attenuation of the ultrasonic waves during the penetration process. When some superficial tissues are examined, in order to overcome the influence of image quality caused by a blind area (when ultrasonic scanning is carried out, an area which is very close to a radiation surface of a probe cannot form good sound wave superposition, so that an echo signal is weak, and the quality of a generated image lacks clinical diagnosis significance, in the field of ultrasound, the distance is called as the blind area, and the unit is mm), the probe needs to be away from the skin-mucosa by a certain distance so as to obtain good image quality. The common ultrasonic couplant is pasty hydrogel and cannot meet the use requirement.
For this case, an ultrasound coupling pad (sheet-like hydrogel elastomer) has been used to isolate the probe (or treatment head) from the skin-mucosa by air. In addition, when the ultrasonic coupling pad is used, the probe (or the treatment head) directly slides on the smooth coupling pad, so that the friction between the probe (or the treatment head) and the skin-mucosa of a patient is avoided, the damage of the friction force to the silica gel layer on the ultrasonic radiation surface of the probe (or the treatment head) is reduced, and the function of protecting the probe (or the treatment head) is achieved. The ultrasonic coupling pad is used for ultrasonic examination or treatment, and can be used for one time, so that the probability of cross infection in a hospital is reduced. Meanwhile, when the ultrasonic coupling pad is used for ultrasonic examination or treatment, the lubricant (generally comprising water, propylene glycol, glycerin and the like) remained on the patient is easy to erase, and even if the lubricant is naturally dried, no stain is remained on clothes, so that the ultrasonic coupling pad is convenient to use.
Chinese patent publication No. CN 105536005a discloses a solid medical ultrasonic coupling patch and a preparation method thereof, wherein the ultrasonic coupling patch comprises the following components by mass percent: 1.0 to 6.0 percent of sodium alginate polymer, 1.0 to 5.0 percent of carrageenan, 0.03 to 0.05 percent of xanthan gum, 0.1 to 0.8 percent of hydroxymethyl cellulose, 2.0 to 15 percent of propylene glycol, 2.0 to 15 percent of glycerol, 0.01 to 0.12 percent of preservative and the balance of deionized water.
The technical scheme is carried out by taking sodium alginate as a main synthetic material and taking the basic principle that the sodium alginate can rapidly generate ion exchange to form gel when meeting calcium ions with certain concentration as the main synthetic material. Sodium alginate is polysaccharide food gum extracted from brown algae, and can be formed into gel after heating and cooling in the presence of multivalent cations (such as Ca2+, Cu2+, etc.) with certain concentration. In the mechanism of forming Ca2+ induced sodium alginate gel, the egg box model is widely accepted, namely under the condition of the existence of Ca2+, after the content of G unit in sodium alginate reaches a certain value, the sodium alginate mainly exists in a double helix structure, the guluronic acid in the G unit is arranged in a cavity with a negative charge to form an egg box structure, and when the sodium alginate and Ca2+ interact, the Ca2+ is firstly combined with the G unit with the egg box structure to form polymer gel.
The technical scheme has the following defects that: when the sodium alginate gel system is used for ultrasonic examination or treatment, the degradation caused by the mechanical effect, the cavitation effect and the thermal effect of ultrasonic waves can affect the image quality, and the colloid stability risk exists.
In addition, chinese patent publication No. CN 106692997 a discloses a disinfection sterilization type solid medical ultrasonic coupling patch and a preparation method thereof, wherein carrageenan, modified bletilla striata polysaccharide and carboxymethyl chitosan are used to prepare gel. The disinfection sterilization type solid medical ultrasonic coupling patch provided by the invention has good biocompatibility, no cytotoxicity, no irritation and no allergy.
For another example, chinese patent publication No. CN107510851A discloses a medical ultrasonic coupling pad and a method for preparing the same, which comprises preparing a coupling pad from glucomannan, xanthan gum, carrageenan, gellan gum, glycerin, a preservative, a pH neutralizer and deionized water according to certain steps.
The prior art, including the two patents mentioned above, is sold as a ready-made coupling pad, and is generally manufactured by a more complex process, and sold as a finished coupling pad, which has at least the following drawbacks: 1. the quality guarantee period is short, generally about one year, and 2, the factory leaving time is long, so that the image quality is influenced; 3. increasing the costs of manufacture, transportation, etc. for the manufacturer.
Disclosure of Invention
The invention aims to provide medical ultrasonic coupling pad powder, which overcomes the defects in the prior art and is prepared and used firstly.
The invention adopts the following technical scheme: a medical ultrasonic coupling pad powder comprises collagen, hectorite powder, starch-based polymer, and pea peptide.
In the technical scheme, the components which are suitable for being prepared on site and can ensure the clear ultrasonic images are selected, the hectorite disclosed by the application has strong gelling performance, the starch-based polymer is added, and the hectorite colloid is formed among the network structures of the starch polymer, so that the stability of the gel is improved. The collagen is added, partial denaturation is carried out in the preparation process, partial protein denaturation is carried out, molecules are enlarged, the fluidity is relatively poor, the forming degree of the coupling pad in the preparation process is improved, and the coupling pad is favorable for blocking.
Further, the medical ultrasonic coupling pad powder comprises 12-15 parts by weight of collagen, 1-1.5 parts by weight of hectorite powder, 0.5-1.2 parts by weight of starch-based polymer and 5-10 parts by weight of pea peptide.
Still more preferably, the medical ultrasonic coupling pad powder comprises 15 parts by weight of collagen, 1.5 parts by weight of hectorite powder, 1.0 part by weight of starch-based polymer and 5-10 parts by weight of pea peptide.
Preferably, the starch-based polymer is corn starch grafted acrylamide.
Preferably, the grafting ratio of the corn starch grafted acrylamide is 55-60%.
Preferably, the particle size of the lithium soap stone powder is 45-100 microns, which is beneficial to gelling the coupling pad powder.
Preferably, the medical ultrasonic coupling pad powder is made into capsules or bags. Convenient for packaging, transportation and use.
Further preferably, each bag or capsule contains 2.5-5 g. Is a common type, and is more convenient to use by one bag or one capsule.
Further preferably, the gel is formed into a capsule shape.
The use method of the medical ultrasonic coupling pad powder comprises the following specific steps:
(1) putting 80-85 ℃ boiled water into a container;
(2) pouring the powder of the coupling pad into boiled water, stirring while pouring, and stirring for about 2-4 minutes;
(3) and (3) pouring the solution obtained in the step (2) into a shaping container, cooling, and taking out for use after shaping.
Preferably, the stirring in step (2) is performed in the same direction.
By implementing the technical scheme, the invention has the following advantages: the couplant powder provided by the invention is simple to use, can be prepared on site at present, is quick to prepare, is convenient and simple to prepare, has clear ultrasonic images, and is more convenient to transport, store and use in a capsule or bag form.
Drawings
FIG. 1 is a diagram of a coupling pad made in accordance with one embodiment of the present invention;
FIG. 2 is an ultrasonic image without a coupling pad;
FIG. 3 is an ultrasonic image of the coupling pad of example 1 according to the present invention;
fig. 4 is an ultrasonic image of the coupling pad of embodiment 2 of the present invention.
Detailed Description
The technical solution of the present invention is further described in detail by the following specific examples.
Example 1:
the medical ultrasonic coupling pad powder comprises 12 parts by weight of collagen, 1 part by weight of hectorite powder, 1.2 parts by weight of corn starch grafted acrylamide and 5 parts by weight of pea peptide. Making into capsule. The capsule size can be made in different sizes. Generally, 2.5 to 5g of powder is contained.
The use method of the medical ultrasonic coupling pad powder comprises the following specific steps:
(1) preparing 80-degree boiled water and putting the boiled water in a container;
(2) pouring the powder of the coupling pad into boiled water, stirring while pouring, and stirring for about 2 minutes;
(3) and (3) pouring the solution obtained in the step (2) into a shaping container, cooling, taking out after shaping, and placing on the body surface of a patient for ultrasonic examination. The specification size is mainly 90mm 3.0mm (diameter thickness), 115mm 2.0 mm.
Example 2:
the medical ultrasonic coupling pad powder comprises 15 parts by weight of collagen, 1.5 parts by weight of hectorite powder, 1.0 part by weight of corn starch grafted acrylamide and 10 parts by weight of pea peptide. Making into capsule. The capsule size can be made in different sizes. Generally, 2.5 to 5g of powder is contained.
The use method of the medical ultrasonic coupling pad powder comprises the following specific steps:
(1) putting 85-degree boiled water into a container;
(2) pouring the powder of the coupling pad into boiled water, stirring while pouring, and stirring for about 2-4 minutes;
(3) and (3) pouring the solution obtained in the step (2) into a shaping container, cooling, taking out after shaping, and placing on the body surface of a patient for ultrasonic examination. The specification size is mainly 115mm 3.0mm (diameter thickness), 140mm 2.0 mm.
Example 3:
the medical ultrasonic coupling pad powder comprises 15 parts by weight of collagen, 1.5 parts by weight of hectorite powder, 1.0 part by weight of starch grafted acrylamide and 6 parts by weight of pea peptide. The powder is bagged. Generally, 2.5 to 5g of powder is contained.
The use method of the medical ultrasonic coupling pad powder comprises the following specific steps:
(1) putting 85-degree boiled water into a container;
(2) pouring the powder of the coupling pad into boiled water, stirring while pouring, and stirring for about 4 minutes;
(3) and (3) pouring the solution obtained in the step (2) into a shaping container, cooling, taking out after shaping, and placing on the body surface of a patient for ultrasonic examination. The specification sizes are mainly 90mm × 2.0mm (diameter × thickness), 90mm × 3.0mm, 115mm × 2.0mm, and 115mm × 3.0 mm.
Example 4:
a medical ultrasonic coupling pad powder comprises 13 parts by weight of collagen, 1.2 parts by weight of hectorite powder, 1.0 part by weight of starch-based polymer and 8 parts by weight of pea peptide. The powder is bagged. Generally, 2.5 to 5g of powder is contained.
The use method of the medical ultrasonic coupling pad powder comprises the following specific steps:
(1) putting 85-degree boiled water into a container;
(2) pouring the powder of the coupling pad into boiled water, stirring while pouring, and stirring for about 4 minutes;
(3) and (3) pouring the solution obtained in the step (2) into a shaping container, cooling, taking out after shaping, and placing on the body surface of a patient for ultrasonic examination. The specification sizes are mainly 90mm × 2.0mm (diameter × thickness), 90mm × 3.0mm, 115mm × 2.0mm, and 115mm × 3.0 mm.
Comparative example 1:
a medical ultrasonic coupling pad powder comprises 13 parts by weight of collagen, 1.2 parts by weight of carrageenan, 1.0 part by weight of starch-based polymer and 8 parts by weight of pea peptide.
According to the comparative example, the common carrageenan replaces the hectorite powder, and during the preparation process, the gelling property is poor, the agglomeration is easy, and clear and transparent gel is difficult to present.
Comparative example 2:
a medical ultrasonic coupling pad powder comprises dextran glycan 0.6%, xanthan gum 0.4%, carrageenan 0.8%, gellan gum 0.1%, glycerol 6.8%, and water in balance. The glue can not be quickly formed. Complete curing takes several hours.
Comparative example 3:
a medical ultrasonic coupling pad powder comprises 12 parts by weight of collagen, 1 part by weight of carrageenan, 1.2 parts by weight of corn starch grafted acrylamide and 5 parts by weight of pea peptide. Carrageenan is used instead of hectorite. Poor gelling property and easy agglomeration.
Comparative example 4:
a medical ultrasonic coupling pad powder comprises 12 parts by weight of collagen, 1 part by weight of sodium alginate, 1.2 parts by weight of corn starch grafted acrylamide and 5 parts by weight of pea peptide. Sodium alginate is used instead of hectorite. The coupling pad is not obtainable directly according to the formulation method in this application.
Claims (9)
1. The medical ultrasonic coupling pad powder is characterized by comprising the following raw materials in parts by weight: 12-15 parts of collagen, 1-1.5 parts of hectorite powder, 0.5-1.2 parts of starch-based polymer and 5-10 parts of pea peptide.
2. The medical ultrasound coupling pad powder of claim 1, wherein the collagen is 15 parts by weight, the hectorite powder is 1.5 parts by weight, the starch-based polymer is 1.0 part by weight, and the pea peptide is 5-10 parts by weight.
3. The medical ultrasound coupling pad powder according to claim 1 or 2, wherein the starch-based polymer is corn starch grafted acrylamide.
4. The medical ultrasonic coupling pad powder according to claim 3, wherein the grafting ratio of the corn starch grafted acrylamide is 55-60%.
5. The medical ultrasound coupling pad powder according to any one of claims 1 to 2, wherein the particle size of the hectorite powder is 45 to 100 microns.
6. The medical ultrasound coupling pad powder of claim 1, wherein the powder is packaged in a capsule or a bag.
7. The medical ultrasound coupling pad powder of claim 6, wherein the coupling pad powder in each individual package weighs between 2.5 g and 5 g.
8. A method for preparing a medical ultrasonic coupling pad by using the medical ultrasonic coupling pad powder of claim 1 is characterized by comprising the following specific steps:
(1) putting 80-85 ℃ boiled water into a container;
(2) pouring the coupling pad powder into boiled water, stirring while pouring, and stirring for 2-4 minutes;
(3) and (3) pouring the solution obtained in the step (2) into a shaping container, cooling, and taking out for use after shaping.
9. The method of claim 8, wherein the stirring in step (2) is in the same direction.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0904295A2 (en) * | 2009-10-30 | 2011-06-28 | Petroleo Brasileiro Sa | process of obtaining superabsorbent crosslinked nanocomposites |
| CN102862346A (en) * | 2012-09-12 | 2013-01-09 | 天津市志润德科技有限公司 | High toughness self-cooling refrigerating gel pad and application thereof |
| CN104341556A (en) * | 2014-10-10 | 2015-02-11 | 齐鲁工业大学 | Preparation method of high-strength double-network nano hectorite composite aquagel |
| CN109069129A (en) * | 2016-03-04 | 2018-12-21 | 伯东株式会社 | For improving the composition, echo gel composition and ultrasonic diagnosis method of ultrasonic transmission efficiency |
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| US20130211542A1 (en) * | 2012-02-08 | 2013-08-15 | The Regents Of The University Of California | Synthesis of nanotopographic biomimetic membranes for tissue culture, engineering and prosthetics applications |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0904295A2 (en) * | 2009-10-30 | 2011-06-28 | Petroleo Brasileiro Sa | process of obtaining superabsorbent crosslinked nanocomposites |
| CN102862346A (en) * | 2012-09-12 | 2013-01-09 | 天津市志润德科技有限公司 | High toughness self-cooling refrigerating gel pad and application thereof |
| CN104341556A (en) * | 2014-10-10 | 2015-02-11 | 齐鲁工业大学 | Preparation method of high-strength double-network nano hectorite composite aquagel |
| CN109069129A (en) * | 2016-03-04 | 2018-12-21 | 伯东株式会社 | For improving the composition, echo gel composition and ultrasonic diagnosis method of ultrasonic transmission efficiency |
Non-Patent Citations (3)
| Title |
|---|
| "Diffusion and Binding of Laponite Clay Nanoparticles into Collagen Fibers for the Formation of Leather Matrix";Jiabo Shi et al;《Langmuir》;20180528;第34卷;第7379-7385页 * |
| "锂皂石复合聚合物纳米凝胶的研究";胡俊燕 等;《化工新型材料》;20140531;第42卷(第5期);第126-129页 * |
| Gelatin Effects on the Physicochemical and Hemocompatible et al;Changpeng Li et al;《ACS Appl. Mater. Interfaces》;20150723;第7卷;第18732-18741页 * |
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