KR102137820B1 - Gel pad for Ultrasonic wave of musculoskeletal - Google Patents

Abstract

The present invention relates to a gel pad for an ultrasound examination of a musculoskeletal system, which is an intermediate layer medium during a musculoskeletal ultrasound examination, and can minimize discomfort and displeasure in use while increasing the resolution and clarity of an ultrasound image, and identify the need for a medical procedure on a lesion site during the ultrasound examination of the musculoskeletal system. The gel pad for an ultrasound examination of a musculoskeletal system, according to the present invention, comprises 3 to 15 wt% of glycerin, 20 to 30 wt% of butylene glycol, 1 to 3 wt% of locust bean gum, 0.1 to 1 wt% of xanthan gum, 1 to 3 wt% of kappa carrageenan, 0.01 to 0.1 wt% of sodium polyacrylate, 0.01 to 0.1 wt% of disodium EDTA, 0.5 to 3 wt% of 1,2-hexanediol, 0.001 to 0.05 wt% of sodium hydroxide, and 0.05 to 0.5 wt% of potassium chloride, 0.01 to 0.1 wt% of ethanol, and the rest of purified water. The gel pad includes: a pad body (10) having an outer shape manufactured in a circular or square shape; and at least two medical procedure guide holes (20) which are formed on the surface of the pad body (10) to be spaced apart from each other and penetrate from the upper surface to the lower surface of the pad body (10).

Description

Gel pad for ultrasonic wave musculoskeletal

The present invention relates to a gel pad for musculoskeletal ultrasound examination that can minimize discomfort and discomfort in use while improving resolution and clarity of ultrasound images as an intermediate layer medium during musculoskeletal ultrasound examination.

Ultrasound is a method of examining abnormalities in body tissues using ultrasound. After ultrasound is transmitted into a body part to be measured, ultrasound is acquired as an image to determine whether abnormal tissues are present.

Currently, ultrasound is widely used not only for diagnosis of lesion tissue such as tumors or fetuses, but also for most medical tests.

On the other hand, for ultrasound examination, ultrasound must be applied to a tissue inside a desired body using an ultrasonic probe that oscillates ultrasound. However, when there is air between the ultrasound probe and the contact skin surface, ultrasound is not properly transmitted to the body due to attenuation or the like. In other words, in the air and skin interface, almost all of the ultrasound waves are 100% reflected, and even if there are very fine bubbles, the propagation of the ultrasound waves is significantly reduced, and it is very difficult to obtain a clear resolution and an image.

To solve this, a method of placing a couplant between the ultrasonic probe and the surface of the body part and contacting the ultrasonic probe on the media is used. These mediators form an intermediate layer as an ultrasonic transmission medium to minimize the transmission loss of ultrasonic waves so that a clear image of tissue can be obtained.

In general, the mediator uses a liquid gel product, but this gives an unpleasant feeling to the patient when the surface of the body is applied, and the ultrasonic probe is operated after application to evaporate after a certain period of time, or to a liquid that is not needed. There was an inconvenient problem in that the gel was pushed out and used continuously.

In addition, since the ultrasonic probe is still forced to directly contact the surface of the body part, the ultrasonic probe may cause an infection problem due to contact in the process of use.

Accordingly, Patent No. 0511341 (a gel pad for ultrasound including carrageenan and a method of manufacturing the same) has been disclosed to solve the above problems.

The Patent No. 0511341 is carrageenan 01-10% by weight, polyhydric alcohol 0-10% by weight, preservative 0005-06% by weight in water and heating and stirring to prepare an aqueous solution; Pouring the aqueous solution of the above step into a tray and maintaining the aqueous solution temperature at 10-40° C. to form a gel; And it consists of the step of wrapping the sheet of the above step, it is a technology aimed at increasing the resolution and clarity of the image.

However, the above technique is made by synthetic polymer crosslinking, and it is impossible to have the same acoustic impedance as water due to the addition of a polymer compound to water molecules, and the structure of the organs within the bend or near field of appearance is impossible. When used for ultrasonic inspection to obtain, as a result, there is a limit to obtaining a clear image and resolution, and the manufacturing cost is high, which is inefficient in terms of commercial use.

Meanwhile, patent registration No. 10-1725311 is disclosed as a technique for minimizing inconvenience and discomfort of a user while obtaining a clear image and resolution.

In the above patent, purified water, disodium IDT and 1,2-hexanediol and sodium hydroxide are mixed as additives, glycerin and methylpropanediol are added as a moisturizer, and locust bean gum, glucomannan, and carrageenan are mixed as gums. It is composed of a mixture of AGE-60 Hydrogenated Castor Oil and fragrance.

However, the patent has a hassle that the essence of the hydrogel pad must be filled after the hydrogel pad is introduced into the pouch for packaging, and the hydrogel due to the conflicting action between the essence and the hydrogel pad. There was a change in the strength of the pad, and it was difficult to use due to the decrease in strength when used after long storage.

In addition, when the hydrogel pad was used, there was stickiness, and as carrageenan was added, although it had a sliding effect with a water-dispersion performance, it did not exhibit smooth sliding.

In addition, the conventional gel pad is generally performed after ultrasound examination when ultrasound treatment, especially musculoskeletal ultrasound examination, is required. However, this method has a problem in that it is cumbersome with an increase in time due to procedural problems as the ultrasound examination and the procedure are separately performed.

Republic of Korea Patent Registration No. 10-1725311 (2017.04.04., water-soluble hydrogel pad composition for ultrasonic inspection and pad manufacturing method using the composition) Republic of Korea Registered Patent Publication No. 10-0511341 (August 23, 2005, gel pad for ultrasound including carrageenan and method for manufacturing the same) Republic of Korea Patent Publication No. 10-1999-0064566 (August 05, 1999, Biosonic ultrasonic gel and its use) Republic of Korea Patent Publication No. 10-2008-0080510 (2008.09.04., ultrasonic phantom gel)

The present invention, while improving the resolution and clarity of the ultrasound image, and at the same time, studied the pads for ultrasonic inspection without any inconvenience in use, the sliding amount is very good, and the sliding effect is very good and the stickiness during sliding is high. In addition, it is to provide a gel pad for musculoskeletal ultrasound examination that allows the treatment of a lesion site during musculoskeletal ultrasound examination.

Gel pad for musculoskeletal ultrasound examination of the present invention for solving the above problems is 3 to 15% by weight of glycerin, 20 to 30% by weight of butylene glycol, 1 to 3% by weight of locust bean gum, and 0.1 to 1 of xanthan gum Weight percent, 1 to 3 weight percent of kappa carrageenan, 0.01 to 0.1 weight percent of sodium polyacrylate, 0.01 to 0.1 weight percent of disodium IDT, 0.5 to 3 weight percent of 1,2-hexanediol, and sodium A pad body 10 made of 0.001 to 0.05% by weight of hydroxide, 0.05 to 0.5% by weight of potassium chloride, 0.01 to 0.1% by weight of ethanol, and the rest composed of purified water, and manufactured in a circular or square shape, It consists of at least two or more surgical guide holes 20 spaced apart from each other on the surface of the pad body 10 and penetrated from the upper surface of the pad body 10 to the lower surface.

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According to the gel pad for ultrasonic inspection of the present invention made of the above configuration, since it is a skin-friendly material, it is harmless to the skin and has excellent moisturizing effect, as well as excellent image clarity and clarity, especially sliding effect without stickiness. It is excellent and has a very good usability.

In addition, according to the present invention, when a procedure is required during ultrasound, the procedure tool is inserted into the procedure guide hole to simultaneously perform the procedure with ultrasound, thereby reducing the accuracy of the procedure as well as the treatment time.

1 is a perspective view showing a gel pad for ultrasound examination according to the present invention.

Hereinafter, a gel pad composition for musculoskeletal ultrasound examination according to a preferred embodiment of the present invention and a gel pad prepared from the composition will be described in detail with reference to the accompanying drawings.

Gel pad composition for musculoskeletal ultrasound examination according to the present invention, 3 to 15% by weight of glycerin, 20 to 30% by weight of butylene glycol, 1 to 3% by weight of locust bean gum, 0.1 to 1% by weight of xanthan gum, 1 to 3% by weight of kappa carrageenan, 0.01 to 0.1% by weight of sodium polyacrylate, 0.01 to 0.1% by weight of disodium IDA, 0.5 to 3% by weight of 1,2-hexanediol, and 0.001 of sodium hydroxide It is composed of ~0.05% by weight, 0.05~0.5% by weight of potassium chloride, 0.01~0.1% by weight of ethanol, and the rest with purified water.

As a gelling agent added for the gelation of the composition, locust bean gum and carrageenan are usually added. In the present invention, by adding the kappa carrageenan, the aqueous solution is increased as compared to the general carrageenan and the strength of the gel becomes better. have.

In addition to this, by adding xanthan gum as described above, the strength of the gel is further increased.

When explaining the properties of the main components constituting the gel pad composition for musculoskeletal ultrasound examination,

1) Glycerin (glycerin): As a component contained in the fats and plants of animals and plants, it is highly viscous, has wettability and unique solubility, and is used as a viscous agent, moisturizer, fragrance, and solvent.

2) Butylene Glycol: It is a material that is mainly used as a moisturizer due to its strong property of attracting moisture, and is also used as a preservative because it has an antimicrobial effect. Butylene glycol is used as a wetting agent that maintains the skin moisture due to the slow evaporation of the skin moisture, and it has less toxicity and irritation to the skin and less stickiness.

In addition, it acts as a solvent agent, as well as fixing the formulation and slowing the scent.

3) Locust bean gum: white or yellowish white powder with a characteristic odor. Locust soybean gum is obtained by collecting and purifying the endosperm after harvesting from the beans growing on the Mediterranean coast and the perennial evergreen tree, the carob tree. The molecule of locust bean gum is a chain-shaped polymer, the main component of which is a mixture ratio of mannose and galactose in a 4:1 ratio, and a molecular weight of about 300,000 neutral polysaccharides. It is difficult to dissolve in cold water, but when heated to 60°C or higher, it becomes transparent and melts into a viscous liquid with good water retention. The viscosity of the solution is relatively stable, but it is easy to decay and the viscosity rapidly decreases. However, it is synergistic when used with other polysaccharides.

4) Xanthan gum: It has excellent heat resistance, and in particular, if it contains glacial acetic acid or citric acid, the viscosity is low even when heated. Natural thickeners have a decrease in viscosity when acidic or alkaline substances coexist, but xanthan gum does not decrease in viscosity due to pH, and is stable even within the range of pH2-13. Xanthan gum has a good viscosity compared to other thickeners and gradually increases in viscosity with concentration.

5) Kappa carrageenan: Carrageenan, which is used as a gelling agent, is a natural polymer material produced from red-haired bean sprouts, stonefish, and the like. Carrageenan is a complex polysaccharide extracted from red algae that grows in clean waters, and is used as a dispersant, emulsifier, swelling agent, thickener, binder, dietary fiber, anti-crystallizer and gelling agent in food applications. In addition to food, it is expected to be applied in pharmaceuticals, cosmetics and other fields.

Carrageenan is an anionic polymer with a strong hydrophilic sulfuric acid group, depending on the content and location of the sulfuric acid group, kappa, lambda, iota, mu, and furcellaran It is divided into.

Of these, kappa carrageenan is easier to manufacture as a formulation than other types of carrageenan, and can form a hard gel, exerting a plumping effect that gives a sense of volume.

6) Sodium polyacrylate: As a sodium salt of acrylic acid polymerization, it is mainly used as an emulsifying stabilizer, viscosity increasing agent (aqueous), film forming agent, skin conditioning agent (softening agent) and absorbent.

7) Disodium EDTA: As an ion-to-ion bonding inhibitor, ions in water (metals, etc.) generally react and deteriorate over time, and are added to prevent this. As a result, disodium LED is a component that acts as a preservative.

8) 1,2-hexanediol (1,2-hexanediol): Alpha-lipoic acid (Alpha-lipoic acid), diosgenine (diosgenine), glucosamine (glucosamine), etc., an organic compound, has an antioxidant effect, In addition, it has high usability with water (purified water), etc. and does not significantly affect formulation changes, and has product stabilization, solvent and moisturizing functions.

9) Sodium hydroxide: Also called sodium hydroxide (NaOH), it is a representative strong base and absorbs water vapor in the air and dissolves itself. In addition, sodium hydroxide also absorbs carbon dioxide, and since it is soluble in water to some extent, it can absorb carbon dioxide in both a solid state and an aqueous solution. Sodium hydroxide that absorbs carbon dioxide turns into sodium carbonate.

10) Potassium chloride: It is obtained from a mineral called sylvite, and is a salt component that is an inorganic salt, soluble in water, and acts as a thickener in cosmetics. On the other hand, potassium chloride is used in patients with electrolyte imbalance as a medicine.

In the present invention, the disodium ID is a component that acts as a preservative, and when added to less than 0.01% by weight, deterioration of the final product can be achieved in a short time, and when it exceeds 0.1% by weight, the ionic reaction increases rapidly. This affects the properties of the final product.

The 1,2-hexanediol is a component that performs a stabilizing function of the product, and if added at less than 0.5% by weight, the moisturizing effect of the product is negligible, and when added in excess of 3% by weight, potential toxicity may occur in the product.

The glycerin is a highly viscous, wettable and soluble component. When added to less than 3% by weight, drying of the product proceeds quickly, and when it exceeds 15% by weight, there are many fats and oils, which causes problems in formulation of the product. Occurs.

The butylene glycol is a component used as a moisturizer and humectant. When added to less than 20% by weight, the effect of maintaining skin moisture may be minimal and stickiness may occur, and when it exceeds 30% by weight, there is too much moisture in the skin. There is a hassle and inconvenience in use, such as a residual feeling.

Therefore, it is preferable that the butylene glycol is composed by mixing 20 to 30% by weight.

The kappa carrageenan is easier to manufacture as a formulation than other types of carrageenans, and can form a hard gel as well as exert a plumping effect that gives a sense of volume.

Therefore, compared to the conventional gel pad, the amount of the sap solution is increased, and the strength of the gel is excellent, which is convenient for use.

On the other hand, in the present invention, the addition of butylene glycol and kapacaraninan does not require the filling of the essence separately when packaging the gel pad, so that there is no hassle in the packaging process due to the secondary filling.

In particular, in the case of using a gel pad after being stored in a pouch for a long time in the prior art, a change in the strength of the gel pad, such as a decrease in the strength of the gel pad, occurred due to the conflicting action between the essence and the gel pad. As it has a sufficient sliding effect, it has the advantage of packaging without additional essence filling.

In addition, as the sodium polyacrylate has flexibility as well as film formation, it is possible to maximize a sliding effect during ultrasound. When the sodium polyacrylate is added in excess of 0.1% by weight, stirring is not smoothly achieved due to the adhesion effect of the sodium polyacrylate, and it can become too hard.

Therefore, the sodium polyacrylate should not exceed 01.1% by weight, and if added too little, the film may not be properly formed or added at least 0.01% by weight as the softening effect is insignificant.

As described above, the gel pad composition for musculoskeletal ultrasound examination of the present invention has no stickiness compared to a conventional gel pad by adding butylene glycol, and it is possible to maximize the slide movement effect by adding sodium polyacrylate, and it can be used to increase the kappa carrageenan. The addition of is to increase the strength of the gel as well as to increase the amount of aqueous solution.

Hereinafter, the present invention will be described in more detail through examples and experimental examples.

[Example] Preparation of gel pad for ultrasonic examination of musculoskeletal system

After adding an additive, a moisturizer, and gums to purified water, the mixture was heated and stirred, cooled to 75° C., subjected to a defoaming process, and then molded to prepare a circular gel pad.

Sodium polyacrylate, disodium IDT, 1,2-hexanediol, and sodium hydroxide were added as additives. Glycerin, butylene glycol methylpropanediol, potassium chloride and ethanol were added as moisturizers. Locust soybean gum, xanthan gum, carrageenan and kappa carrageenan were added, and as shown in Table 1, the components and contents contained in Examples 1 to 4 were separately prepared.

Raw material name Example 1 Example 2 Example 3 Example 4 Purified water 65.655 65.775 64.627 63.802 glycerin 10 5 5 5 Methylpropanediol 19 24 25 - Butylene Glycol - - - 25 Locust Bean Sword 1.725 1.725 1.725 2 Xanthan gum 0.5 0.2 0.5 0.5 Sodium polyacrylate - - 0.02 0.02 Carrageenan 1.45 1.45 1.45 - Kappa carrageenan - - - 2 Disodium LED 0.05 0.05 0.05 0.05 1,2-hexanediol 1.5 1.3 1.5 1.5 ethanol 0.02 0.5 0.02 0.02 Sodium hydroxide - - 0.008 0.008 Potassium chloride 0.1 - 0.1 0.1 Sum 100 100 100 100

The gel strength of the gel pad made of the above ingredients, the sap solution, and the sliding effect were tested.

The grades were divided into low, medium, medium, high and high.

As shown in Table 2, the experimental results confirmed that the strength of Examples 3 and 4 to which kappa carrageenan was added was very excellent compared to that of carrageenan.

The aqueous solution is medium in Example 1 with a small amount of methylpropanediol added, while Example 2 and Example 3 have high levels, whereas Example 4 in which butylene glycol is added instead of methylpropanediol is used in Example 2 and It was confirmed that it was superior to 3.

In addition, as a result of the sliding effect test of the gel pad, Example 1 in which the amount of methyl propane diol was small and sodium polyacrylate was not added was in the middle, and the amount of methyl propane diol was more than a certain amount and sodium polyacrylate was not added Example 2 is a higher intermediate than Example 1, and Example 3 in which methyl propanediol and sodium polyacrylate were added was superior in phase, and the sliding effect of Example 4 in which butylene glycol and sodium polyacrylate was added was It was confirmed that it was very excellent with the highest higher than Example 3.

Gel strength Sum Sliding effect Example 1 Prize medium medium Example 2 Prize Prize slander Example 3 Prize Prize Prize Example 4 the best the best the best

As shown in the results of Table 2, when glycerin and butylene glycol were used, glycerin and methyl propanediol were used, and the sliding effect was excellent without stickiness. When sodium polyacrylate was added, The sliding effect could be further maximized.

In addition, in the case of carrageenan, which determines the amount of the aqueous solution, when the addition of kappa carrageenan than the general carrageenan, the aqueous solution increases, and a gel with very good strength can be produced.

Meanwhile, a gel pad for musculoskeletal ultrasound examination made of the above-described composition will be described.

The gel pad of the present invention, as shown in Figure 1, the outer shape of the pad body 10 is manufactured in a circular or square, and the surface of the pad body 10 to be penetrated from the top surface of the pad body 10 to the bottom surface It consists of a surgical guide hole (20) formed.

The thickness of the pad body 10 may be manufactured to approximately 2 to 4 mm, and when it exceeds 4 mm, the thickness may become too thick and a problem in transparency may occur.

At least two treatment guide holes 20 are formed to be spaced apart from each other.

The diameter of the procedure guide hole 20 may be formed to be about 2 to 5 mm as long as the procedure instrument can be fitted.

The gel pad of the present invention has the advantage that the surgical guide hole 20 is formed, so that the lesion can be checked while the lesion is generated during ultrasound diagnosis. Such a procedure can be used more effectively in the diagnosis of musculoskeletal related ultrasound, so it is very convenient to use.

10: pad body 20: procedure guide hole

Claims (2)

delete 3 to 15% by weight of glycerin, 20 to 30% by weight of butylene glycol, 1 to 3% by weight of locust bean gum, 0.1 to 1% by weight of xanthan gum, 1 to 3% by weight of kappa carrageenan, and sodium polyacrylate 0.01 to 0.1% by weight, 0.01 to 0.1% by weight of disodium ID, 0.5 to 3% by weight of 1,2-hexanediol, 0.001 to 0.05% by weight of sodium hydroxide, and 0.05 to 0.5% by weight of potassium chloride Wow, 0.01 to 0.1% by weight of ethanol, and the rest is composed of purified water,
Pad body 10 is manufactured in a round or square shape,
Gel pad for ultrasound examination, characterized in that consisting of at least two or more treatment guide holes 20 spaced apart from each other on the surface of the pad body 10 and penetrated from the upper surface to the lower surface of the pad body 10.

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