CN100562307C - A kind of antibiotic toothpaste and manufacture method thereof - Google Patents
A kind of antibiotic toothpaste and manufacture method thereof Download PDFInfo
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- CN100562307C CN100562307C CNB2005100371731A CN200510037173A CN100562307C CN 100562307 C CN100562307 C CN 100562307C CN B2005100371731 A CNB2005100371731 A CN B2005100371731A CN 200510037173 A CN200510037173 A CN 200510037173A CN 100562307 C CN100562307 C CN 100562307C
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Abstract
The invention discloses a kind of antibiotic toothpaste, it includes antibacterial, wetting agent, anion surfactant, binding agent, foaming agent, abrasive, sweeting agent, essence, pigment, acid-base modifier and deionized water, wherein, described antibacterial is a carboxymethyl chitosan, its edible soluble in water and safe, have distinctive anti-microbial property, and boil on the nape opposite the mouth intracavity common pathogen can play inhibitory action, to reach safe bacteriostasis efficacy.The manufacturing process of this antiseptic toothpaste is simple relatively in addition, and lotion of toothpaste stability is good.
Description
Technical field
The present invention relates to a kind of toothpaste and manufacture method thereof, refer in particular to a kind of antibiotic toothpaste and manufacture method thereof.
Background technology
As everyone knows, the main effect of toothpaste is cleaning oral cavity and sterilization, and the antipathogenic composition that adopts in the toothpaste mainly contains following several at present: antibacterial, enzyme preparation, metallic compound, peroxide, quintessence oil and plant extract.Wherein, antibacterial mainly comprises various cationic germicides such as hibitane, and the effect of these antibacterial all obtains confirming, but the foaming agent sodium lauryl sulphate in itself and the toothpaste is difficult to mix, and inherent biocidal efficacies can be weakened greatly even be completely lost; Also have non-ionic antibacterial agents in addition, as triclosan, its antibacterial activity is strong, but with high costs, and is used for toothpaste and whether has potential carcinogenic threat also and imperfectly understand.Enzyme preparation helps to destroy protein, starch and the lipid in the oral cavity, perhaps decomposes oral cavity bacterium, thereby suppresses the formation of dental plaque, but it is easy to by the foaming agent passivation activity that is difficult to keep in toothpaste.Bivalent metallic compound results of use such as zinc, copper, indium are not obvious.Bactericidal effects such as peroxide such as hydrogen peroxide, perphosphoric acid salt are good, but itself stability is bad, and oral mucosa produced stimulate easily, limited its application in toothpaste.Quintessence oil produces direct killing action to antibacterial, but the distinctive unhappy taste of many quintessence oils has limited the use in toothpaste.The plant extract wide material sources, of a great variety, it is good wherein to be no lack of the good safety that produces effect, and toothpaste market is widely used at home.
The toothpaste manufacture method more close with the present invention is: adopt and be insoluble in the chitosan of water as the toothpaste antibacterial, but because it is dissolved in acid flux material, and the antibacterial activity of chitosan only could embody after it is in dissolved state, and toothpaste mostly is neutral to alkalescence, therefore must be in the toothpaste preparation process earlier with acid dissolving chitosan, and according to the security consideration of toothpaste inlet to human body, optimum selection is an acetic acid, but the inherent taste of acetic acid itself can produce a very large impact the taste of tooth paste product, need to reconcile pH value then, add again in the lotion of toothpaste, the dissolution process complexity, many effects limit its application.Another scheme is it to be prepared into the microcapsule shell polysaccharide earlier add in the toothpaste, but the preparation technology of microcapsule is complicated more, makes that the processing technique of toothpaste is very complicated.
In view of this, provide a kind of toothpaste of edible antibacterial agent soluble in water and safe that contains in fact for necessary, to reach safe antibiotic effect.
Summary of the invention
Main purpose of the present invention is to provide a kind of toothpaste that contains edible antibacterial agent soluble in water and safe, and this kind antibacterial has distinctive anti-microbial property, and boil on the nape opposite the mouth intracavity common pathogen can play inhibitory action, to reach safe bacteriostasis efficacy.
The present invention also provides the manufacture method of antiseptic toothpaste.
In order to achieve the above object, the invention provides a kind of antibiotic toothpaste, it includes antibacterial, wetting agent, anion surfactant, binding agent, foaming agent, abrasive, sweeting agent, essence, pigment, acid-base modifier and deionized water, wherein, described antibacterial is a carboxymethyl chitosan.
Wherein, the concentration of described carboxymethyl chitosan is 0.5%-10%; Its best bacteriostatic PH scope is roughly at pH6.0-6.3, and its molecular weight is 2.0 * 10
4-1.2 * 10
5
In one embodiment of the invention, described antiseptic toothpaste also can further include brightening agent, and described brightening agent can be titanium dioxide.
Described abrasivus is a silicon dioxide; Described wetting agent be in glycerol, sorbitol, propylene glycol or the Polyethylene Glycol choose any one kind of them or multiple, promptly above-mentioned several wetting agent can be singly with also can severally being used in combination; Described binding agent can be in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, carrageenan or the HANSHENGJIAO choose any one kind of them or multiple, above-mentioned several wetting agent can singly be used, and also can severally be used in combination; Acid-base modifier can be and adopts citric acid or malic acid is chosen any one kind of them or two kinds.
Below further describe the percentage ratio of each ingredients constitute gross weight in the antibiotic toothpaste:
Prescription one
Antibacterial 0.5-10% wetting agent 18-65%
Binding agent 0.9-1.3% anion surfactant 2%
Abrasivus 15-20% sweeting agent 0.22%
Essence 1.0% pigment 0.0002-0.0005%
Acid-base modifier 0.0005-0.001% deionized water surplus
Prescription two
Antibacterial 0.5-10% wetting agent 18-65%
Binding agent 0.9-1.3% anion surfactant 2%
Abrasivus 15-20% sweeting agent 0.22%
Essence 1.0% pigment 0.0002-0.0005%
Acid-base modifier 0.0005-0.001% brightening agent 0.5%
The deionized water surplus
The manufacture method of this antibiotic toothpaste is as described below:
At first, with deionized water dissolving antibacterial carboxymethyl chitosan and sweeting agent; The molecular weight of used carboxymethyl chitosan is 2.0 * 10
4-1.2 * 10
5
Secondly, acid-base modifier is added above-mentioned solution and stirring and dissolving, the pH scope that makes toothpaste is 6.0-6.3;
Then, in said mixture input system cream pot, pump into wetting agent simultaneously and stir;
Then, suck abrasivus, anion surfactant and binding agent, open scraper plate and agitator, said components is fully mixed;
At last, drop into pigment and essence, the concentration that makes carboxymethyl chitosan is 0.5%-10%, stirs the back discharging, can make described antibiotic toothpaste.
Compared with prior art, the present invention uses the antibacterial carboxymethyl chitosan to make antibacterial toothpaste as the toothpaste additive, and this antibacterial is soluble in water, the security performance height, and bacteriostatic activity is good, and the manufacturing process of this antiseptic toothpaste is simple relatively, and lotion of toothpaste stability is good.
The specific embodiment
The invention provides a kind of antibiotic toothpaste, its form is transparent or opaque mastic, can prevent and treat common dentistry and oral diseases such as periodontitis, dental hemorrhage, halitosis and halitosis.It includes antibacterial, wetting agent, anion surfactant, binding agent, foaming agent, abrasive, sweeting agent, essence, pigment, acid-base modifier and deionized water etc. this antibiotic toothpaste, and wherein, described antibacterial is a carboxymethyl chitosan.
Chitin (Chitin) is that occurring in nature contains one of amino homogeneous state polysaccharide, extensively is present in the Crustacean, and be to be only second to cellulosic natural polymer, and chitosan (Chitosan) is the main derivant that the chitin deacetylase base produces.Wherein, carboxymethyl chitosan (CM-chitosan) is the class chitin derivativ of chitosan behind carboxymethylation reaction.Owing to have free amine group and activity hydroxy in the chitosan molecule, substituted radical can enter O-position and N-position during reaction, then corresponding product has the O-carboxymethyl chitosan, the N-carboxymethyl chitosan is warded off and N, the O-carboxymethyl chitosan, it has favorable biological degradability, biocompatibility, and has no side effect, and has bacteriostasis.In addition, carboxymethyl chitosan another characteristic of great use in toothpaste is to have a stronger moisture pick-up properties, can the displaced sorbitol of part etc. wetting agent commonly used.
In a preferred embodiment of the present invention, according to the best bacteriostatic molecular weight ranges of carboxymethyl chitosan, the molecular weight of the chitosan that uses in toothpaste should be chosen in 2.0 * 10
4-1.2 * 10
5Between, selecting degree of substitution by carboxymethyl DS simultaneously is 0.3-0.8.In toothpaste, the concentration of carboxymethyl chitosan is preferably 0.5%-10%.In addition, the best bacteriostatic PH of carboxymethyl chitosan scope is roughly at Ph6.0-6.3, so meta-alkalescence abrasives such as inapplicable calcium carbonate, calcium hydrogen phosphate, aluminium hydroxide in the toothpaste, preferred abrasivus is a silicon dioxide.
In another embodiment, described antiseptic toothpaste also can further include brightening agent titanium dioxide.
Wherein, described wetting agent can be in glycerol, sorbitol, propylene glycol or the Polyethylene Glycol choose any one kind of them or multiple, promptly above-mentioned several wetting agent can be singly with also can being several being used in combination.Described binding agent can be in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, carrageenan or the HANSHENGJIAO choose any one kind of them or multiple, above-mentioned several wetting agent can singly be used, and also can severally be used in combination.
Acid-base modifier makes that for regulating the effect of toothpaste pH value the concentration of carboxymethyl chitosan is 0.5%-10%, can adopt citric acid or malic acid etc.
The formula range of two groups of antibiotic toothpastes is provided in the present invention, as described below:
Prescription one
Antibacterial 0.5-10% wetting agent 18-65%
Binding agent 0.9-1.3% anion surfactant 2%
Abrasivus 15-20% sweeting agent 0.22%
Essence 1.0% pigment 0.0002-0.0005%
Acid-base modifier 0.0005-0.001% deionized water surplus
Prescription two
Antibacterial 0.5-10% wetting agent 18-65%
Binding agent 0.9-1.3% anion surfactant 2%
Abrasivus 15-20% sweeting agent 0.22%
Essence 1.0% pigment 0.0002-0.0005%
Acid-base modifier 0.0005-0.001% brightening agent 0.5%
The deionized water surplus
Below disclose the optimization formula of a kind of antibiotic toothpaste of the present invention by specific embodiment:
Embodiment one
Carboxymethyl chitosan 0.5% glycerol 5%
Sorbitol 60% sodium carboxymethyl cellulose 0.7%
Carrageenan 0.2% sodium lauryl sulphate 2%
Silica 1 5% glucide 0.22%
Essence 1.0% pigment 0.0002%
Citric acid 0.0005% deionized water surplus
Embodiment two
Carboxymethyl chitosan 5% Polyethylene Glycol 5%
Propylene glycol 10% sorbitol 25%
Sodium carboxymethyl cellulose 0.8% carrageenan 0.4%
Sodium lauryl sulphate 2% silica 1 5%
Glucide 0.22% essence 1.0%
Pigment 0.0005% citric acid 0.0005%
The deionized water surplus
Embodiment three
Carboxymethyl chitosan 10% Polyethylene Glycol 3%
Sorbitol 15% sodium carboxymethyl cellulose 0.9%
Hydroxyethyl-cellulose 0.4% sodium lauryl sulphate 2%
Silicon dioxide 20% titanium dioxide 0.5%
Glucide 0.22% essence 1.0%
Pigment 0.0003% citric acid 0.001%
The deionized water surplus
The manufacture method of antibiotic toothpaste of the present invention is below described:
Step 1, at first, with deionized water dissolving antibacterial and sweeting agent;
Secondly step 2, adds above-mentioned solution and stirring and dissolving with acid-base modifier;
Step 3 then, in said mixture input system cream pot, pumps into wetting agent simultaneously and stirs;
Step 4 then, sucks abrasivus, anion surfactant and binding agent, opens scraper plate and agitator, and said components is fully mixed;
Step 5 drops into pigment and essence after 20 minutes, restir discharging in 10 minutes can obtain the finished product antibiotic toothpaste.
Wherein, antibacterial is a carboxymethyl chitosan.Sweeting agent is a glucide.Anion surfactant is a sodium lauryl sulphate.Abrasivus is a silicon dioxide.Wetting agent can be in glycerol, sorbitol, propylene glycol or the Polyethylene Glycol choose any one kind of them or multiple.Described binding agent can be in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, carrageenan or the HANSHENGJIAO choose any one kind of them or multiple.Acid-base modifier to regulate the concentration of carboxymethyl chitosan, can adopt citric acid or malic acid etc. for regulating the effect of toothpaste pH value.
Above disclosed only is the preferred embodiment of a kind of antibiotic toothpaste of the present invention and manufacture method thereof, certainly can not limit the present invention's interest field with this, therefore the equivalent variations of being done according to the present patent application claim still belongs to the scope that the present invention is contained.
Claims (8)
1. antibiotic toothpaste, it includes antibacterial, wetting agent, anion surfactant, binding agent, foaming agent, abrasive, sweeting agent, essence, pigment, acid-base modifier and deionized water, described antibacterial is a carboxymethyl chitosan, it is characterized in that: the concentration of described carboxymethyl chitosan is 0.5%-10%, the PH scope of described toothpaste is 6.0-6.3, and the molecular weight of described carboxymethyl chitosan is 2.0 * 10
4-1.2 * 10
5
2. antibiotic toothpaste as claimed in claim 1 is characterized in that: described abrasivus is a silicon dioxide; Described wetting agent be in glycerol, sorbitol, propylene glycol or the Polyethylene Glycol choose any one kind of them or multiple, promptly above-mentioned several wetting agent can be singly with also can severally being used in combination; Described binding agent can be in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, carrageenan or the HANSHENGJIAO choose any one kind of them or multiple, above-mentioned several wetting agent can singly be used, and also can severally be used in combination; Acid-base modifier can be and adopts citric acid or malic acid is chosen any one kind of them or two kinds.
3. antibiotic toothpaste as claimed in claim 1 is characterized in that: described antibiotic toothpaste further includes brightening agent, and described brightening agent is a titanium dioxide.
4. as claim 1 or 3 described antibiotic toothpastes, it is characterized in that: the percentage ratio of each ingredients constitute gross weight can be in the following prescription and chooses any one kind of them in the described antibiotic toothpaste:
Prescription one
Antibacterial 0.5-10% wetting agent 18-65%
Binding agent 0.9-1.3% anion surfactant 2%
Abrasivus 15-20% sweeting agent 0.22%
Essence 1.0% pigment 0.0002-0.0005%
Acid-base modifier 0.0005-0.001% deionized water surplus
Prescription two
Antibacterial 0.5-10% wetting agent 18-65%
Binding agent 0.9-1.3% anion surfactant 2%
Abrasivus 15-20% sweeting agent 0.22%
Essence 1.0% pigment 0.0002-0.0005%
Acid-base modifier 0.0005-0.001% brightening agent 0.5%
The deionized water surplus
5. antibiotic toothpaste as claimed in claim 4 is characterized in that: the percentage ratio of each ingredients constitute gross weight is in the described antibiotic toothpaste:
Carboxymethyl chitosan 0.5% glycerol 5%
Sorbitol 60% sodium carboxymethyl cellulose 0.7%
Carrageenan 0.2% sodium lauryl sulphate 2%
Silica 1 5% glucide 0.22%
Essence 1.0% pigment 0.0002%
Citric acid 0.0005% deionized water surplus
6. antibiotic toothpaste as claimed in claim 4 is characterized in that: the percentage ratio of each ingredients constitute gross weight is in the described antibiotic toothpaste:
Carboxymethyl chitosan 5% Polyethylene Glycol 5%
Propylene glycol 10% sorbitol 25%
Sodium carboxymethyl cellulose 0.8% carrageenan 0.4%
Sodium lauryl sulphate 2% silica 1 5%
Glucide 0.22% essence 1.0%
Pigment 0.0005% citric acid 0.0005%
The deionized water surplus
7. antibiotic toothpaste as claimed in claim 4 is characterized in that: the percentage ratio of each ingredients constitute gross weight is in the described antibiotic toothpaste:
Carboxymethyl chitosan 10% Polyethylene Glycol 3%
Sorbitol 15% sodium carboxymethyl cellulose 0.9%
Hydroxyethyl-cellulose 0.4% sodium lauryl sulphate 2%
Silicon dioxide 20% titanium dioxide 0.5%
Glucide 0.22% essence 1.0%
Pigment 0.0003% citric acid 0.001%
The deionized water surplus
8. the manufacture method of an antibiotic toothpaste is characterized in that:
At first, with deionized water dissolving antibacterial carboxymethyl chitosan and sweeting agent; The molecular weight of used carboxymethyl chitosan is 2.0 * 10
4-1.2 * 10
5
Secondly, acid-base modifier is added above-mentioned solution and stirring and dissolving, the pH scope that makes toothpaste is 6.0-6.3;
Then, in said mixture input system cream pot, pump into wetting agent simultaneously and stir;
Then, suck abrasivus, anion surfactant and binding agent, open scraper plate and agitator, said components is fully mixed;
At last, drop into pigment and essence, the concentration that makes carboxymethyl chitosan is 0.5%-10%, stirs the back discharging, can make described antibiotic toothpaste.
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| CNB2005100371731A CN100562307C (en) | 2005-09-13 | 2005-09-13 | A kind of antibiotic toothpaste and manufacture method thereof |
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|---|---|---|---|
| CNB2005100371731A CN100562307C (en) | 2005-09-13 | 2005-09-13 | A kind of antibiotic toothpaste and manufacture method thereof |
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| CN100562307C true CN100562307C (en) | 2009-11-25 |
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| CN103006455A (en) * | 2011-09-27 | 2013-04-03 | 黄庆禄 | Method for preparing chitosan tooth-protection toothpaste |
| AU2014364417A1 (en) | 2013-12-20 | 2016-06-16 | Colgate-Palmolive Company | Core shell silica particles and use for malodor reduction |
| MX354968B (en) | 2013-12-20 | 2018-03-27 | Colgate Palmolive Co | Tooth whitening oral care product with core shell silica particles. |
| CN104127437B (en) * | 2014-07-24 | 2017-12-19 | 北京大清生物技术股份有限公司 | A kind of composition with multiple dental care and health-care efficacy and preparation method thereof |
| CN105031747B (en) * | 2015-08-27 | 2018-01-16 | 北京大清生物技术股份有限公司 | A kind of absorbable tooth extraction wound care composition and preparation method and application |
| CN105168019A (en) * | 2015-10-26 | 2015-12-23 | 青岛高新区尚达医药研究所 | Chitin toothpaste and preparation method thereof |
| CN105232431A (en) * | 2015-11-16 | 2016-01-13 | 鄢祺丹 | Antibacterial gingival-protecting high-efficiency toothpaste with specific component of modified traditional Chinese herbal medicine and preparation method of antibacterial gingival-protecting high-efficiency toothpaste |
| CN106619179A (en) * | 2016-12-20 | 2017-05-10 | 泰州比尔夫生物科技有限公司 | Toothpaste capable of preventing and treating dental ulcers |
| US11771642B2 (en) * | 2017-05-31 | 2023-10-03 | Lg Household & Health Care Ltd. | Pumping type toothpaste composition |
| CN107970133B (en) * | 2017-11-28 | 2021-07-20 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of antibacterial toothpaste, product and application thereof |
| CN108969395A (en) * | 2018-09-03 | 2018-12-11 | 娈垫尝 | One kind containing the toothpaste and preparation method thereof of " jumping candy " |
| CN112933009A (en) * | 2021-02-20 | 2021-06-11 | 深圳市西马龙科技有限公司 | Efficient antibacterial titanium dioxide nano toothpaste |
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