CN101801334B - Oral composition and method of improving astringency of oral composition - Google Patents
Oral composition and method of improving astringency of oral composition Download PDFInfo
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- CN101801334B CN101801334B CN2008801071863A CN200880107186A CN101801334B CN 101801334 B CN101801334 B CN 101801334B CN 2008801071863 A CN2008801071863 A CN 2008801071863A CN 200880107186 A CN200880107186 A CN 200880107186A CN 101801334 B CN101801334 B CN 101801334B
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- potassium sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
Abstract
One or more aluminum compounds (a) selected among potassium aluminum sulfate, anhydrous potassium aluminum sulfate, and ammonium aluminum sulfate and sodium chloride (b) are incorporated into an oral composition, the amount of the ingredient (a) being 0.2-3 mass%. By the method of improving the astringency of an oral composition, an oral composition can be obtained which has a high astringent effect in the oral cavity at the time of use and retains therein the high astringent effect even after use. This oral composition does not have a metallic taste attributable to a polyvalent metal, and has excellent suitability for use and satisfactory safety.
Description
Technical field
The constringent method that the present invention relates to composition for oral cavity and improve composition for oral cavity; The higher convergence effect of performance when this composition for oral cavity uses in the oral cavity; Persistence after use convergence effect is also excellent, and can not feel the metallic taste that derives from polyvalent metal, and usability is good; The effect excellence is tightened up by neck portion, to the prevention of periodontal disease or improve effectively.
Background technology
As the periodontal disease patient's who increases in recent years symptom, enumerate obligate anaerobic property gram negative bacilli with porphyromonas gingivalis (P.gingivalis) etc. and be the pain and the redness of the neck portion that master's bacterial infection causes.So, as to the prevention of such periodontal, improve effective means, in the oral cavity, especially tightening up of neck portion is considered to useful.
As the means of tightening up neck portion, the natural astringent of the polyvalent metal compounds of mixed oxidization zinc or aluctyl. etc. or polyphenol and tannic acid etc. becomes effective means in oral care product.In oral care product in blended these compositions, particularly polyvalent metal compounds is owing to have higher convergence, therefore in composition for oral cavity, mixes and is able to listing.
Yet, mixed the composition for oral cavity of polyvalent metal compounds owing to can produce the metallic taste that derives from polyvalent metal etc., therefore exist to be difficult in the oral cavity, use and its convergence is temporary transient, the problem of persistence difference.
For solving such problem; For example proposed in the patent documentation 1 (Japanese Patent Laid is opened clear 61-186307 communique) to make the enhanced scheme of convergence through mixing sodium carboxymethyl cellulose or sodium alginate in containing the composition for oral cavity of aluctyl.; But the metallic taste in not only using this moment also is enhanced; Be difficult to use, and be difficult to bring into play constantly excellent convergence.
So in composition for oral cavity, mixing astringent component is effectively as preventing, improve periodontal disease, but is difficult to obtain in the oral cavity, bring into play constantly higher convergence and the also good composition for oral cavity of usability with prior art.
Patent documentation 1: Japanese Patent Laid is opened clear 61-186307 communique
Patent documentation 2: Japanese Patent Laid is opened clear 59-157014 communique
Patent documentation 3: japanese patent laid-open 3-258724 communique
Patent documentation 4: japanese patent laid-open 5-58895 communique
Patent documentation 5: Japanese Patent Laid is opened the 2001-163742 communique
Patent documentation 6: Japanese Patent Laid is opened the 2003-212743 communique
Summary of the invention
The purpose of this invention is to provide the higher convergence effect of performance in the oral cavity, and use back convergence effect also to continue, and can not feel composition for oral cavity that metallic taste and usability are excellent and the constringent method that improves composition for oral cavity.
The inventor is the wholwe-hearted research that achieves the above object; The result has known: through and with the aluminium compound more than a kind or 2 kinds that is selected from aluminium potassium sulfate, dry aluminium potassium sulfate, Burnt ammonium alum of (a) 0.2～3 quality % and (b) sodium chloride; Preferably with (b) composition with respect to (a) composition ratio combined hybrid of 0.5～15 by quality ratio, when obtaining in the oral cavity, using the higher convergence effect of performance and also use after also bring into play the higher convergence effect that continues and can not feel metallic taste and the excellent composition for oral cavity of usability.
Also have; Aluminium potassium sulfate, dry aluminium potassium sulfate (anhydride of aluminium potassium sulfate), Burnt ammonium alum are known as Alumen, have astriction or bactericidal action, as food additives; More as the composition that is mixed into oral cavity composition and known, for example patent documentation 2～6 grades proposed.Having put down in writing the toothpaste that contains the azulene chemical compound in the patent documentation 2 stablizes through adding aluminium compound; Put down in writing in the patent documentation 3 through mixing the aluminum salt and the anion surfactant of Alumen etc.; The perceptual hyperesthesia of zinc salt suppresses effect and is improved; Having put down in writing in the patent documentation 4 through what in pyridone or its salt of performance antibacterial action, add aluminium potassium sulfate (Alumen) etc. is metallic compound, Borax and the alkali metal chloride of constituent with aluminum, and solution is able to stabilisation.Put down in writing in the patent documentation 5 through will synthesize unformed titanium bonded silica hydrochlorate as grinding agent, and use aluminum salt; Can improve tartar and suppress effect; Put down in writing in the patent documentation 6 through forming the complex of water soluble aluminum compound and chamenol, brought into play higher perceptual hyperesthesia prevention or therapeutic effect.
For these, the inventor has found: when in oral cavity composition, only mixing above-mentioned Alumen, be difficult to obtain satisfied convergence effect; And usability is also poor, is difficult to carry out practicability, but is selected from the aluminium compound of aluminium potassium sulfate, dry aluminium potassium sulfate, Burnt ammonium alum through (a) that mixes the specific blend amount; And combined hybrid (b) sodium chloride, especially with special ratios and with above-mentioned (a) composition and (b) composition, as from after the embodiment that states can be clear and definite; Above-mentioned two kinds of compositions act on with multiplying each other; Not only the higher convergence effect of performance in intraoral use should the convergence effect also continue after the use, and inhibition derives from the metallic taste of polyvalent metal and obtains excellent usability.
Such action effect of the present invention is thought can be through reaching to get off: aluctyl. etc. are simple aluminum salt (single salt); And the aluminium compound that is selected from aluminium potassium sulfate, dry aluminium potassium sulfate, Burnt ammonium alum is a double salt; This double salt through with the liquefiable balance of intraoral sodium chloride; Be difficult to feel metallic taste, and in using and use the intraoral albuminous degeneration in back to increase specifically, demonstrate excellent convergence effect.Even if aluminium compound, the compositions of having mixed single salt of aluctyl. etc. can not reach action effect of the present invention.
So the present invention provides following composition for oral cavity and gives composition for oral cavity constringent method.
[I] a kind of composition for oral cavity is characterized in that, contains: (a) be selected from the aluminium compound more than a kind or 2 kinds of aluminium potassium sulfate, dry aluminium potassium sulfate, Burnt ammonium alum and (b) sodium chloride, the combined amount of said (a) composition is 0.2～3 quality %.
[II] like the composition for oral cavity of [I] record, with respect to (a) composition, containing is (b) composition of 0.5～15 ratio by quality ratio.
[III] is modulated to toothpaste like the composition for oral cavity of [I] or [II] record.
[IV] improves the constringent method of composition for oral cavity; It is characterized in that; Said composition for oral cavity is the composition for oral cavity that contains the aluminium compound more than a kind or 2 kinds that is selected from aluminium potassium sulfate, dry aluminium potassium sulfate, Burnt ammonium alum; In said composition for oral cavity, mix in the said aluminium compound of 0.2～3 quality %, and use sodium chloride.
[V] like the constringent method of raising of [IV] record, and with respect to (a) composition, mixing is (b) composition of 0.5～15 ratio by quality ratio.
[VI] like the constringent method of raising of [IV] or [V] record, said method is to improve the constringent method of dentifrice composition.
Constringent raising method according to composition for oral cavity of the present invention and composition for oral cavity; Can obtain such composition for oral cavity, the higher convergence effect of performance also can continue higher convergence effect when in the oral cavity, using after the use; Can not feel simultaneously the metallic taste that derives from polyvalent metal; Usability is also excellent, and secure context is also good, may be modulated as various dosage forms and is widely used.
The specific embodiment
Composition for oral cavity of the present invention is as modulation such as the toothpaste agent of toothpaste (toothpaste), liquid tooth paste, aqueous toothpaste, profit system toothpaste etc., collutory; Especially as toothpaste modulation, must contain more than a kind or 2 kinds and (b) sodium chloride that (a) is selected from aluminium potassium sulfate, dry aluminium potassium sulfate, Burnt ammonium alum.
The aluminium compound that is selected from the aluminium potassium sulfate of (a) composition, dry aluminium potassium sulfate (anhydride of aluminium potassium sulfate), Burnt ammonium alum is known with the title of Alumen usually, is the hydrate or the anhydride of the sulfate (double salt) of the aluminum shown in the formula (1) and potassium or ammonium.
R
1Al(SO
4)
2·12H
2O (1)
(in the formula, R
1Be K or NH
4)
As (a) composition; Can use commercially available article; For example, can use potassium alum (big bright chemical industry (strain) manufacturing), can use burnt alum (big bright chemical industry (strain) manufacturing), can use ammonia-alum (big bright chemical industry (strain) manufacturing) etc. as Burnt ammonium alum as dry aluminium potassium sulfate as aluminium potassium sulfate.
(a) aluminium compound of composition can use a kind separately, and also can make up more than 2 kinds and use, wherein, preferred aluminium potassium sulfate or dry aluminium potassium sulfate, perhaps combination and the mixing two components of using separately.
(a) combined amount of composition is 0.2～3% (quality %, below identical) with respect to total composition, preferred 0.3～2%.Less than 0.2% then can not be brought into play the convergence of sufficient persistence sometimes, if above 3%, then produce metallic taste sometimes, sometimes oral mucosa being produced stimulates.
(b) sodium chloride can use commercially available article, the product that for example can use sea of Japan Water Co., Ltd to make as selected superfine salt.The combined amount of sodium chloride is 0.1～15% with respect to total composition, especially preferred 0.2～10%, preferred especially 5～10%.Combined amount less than 0.1% then can not be brought into play the convergence sense of sufficient persistence sometimes, if surpass 15%, then probably can produce saline taste, the oral cavity can not be cleaned fully or oral mucosa produced stimulate.
Mixed proportion ((b)/(a)) with respect to (b) composition sodium chloride of the aluminium compound of (a) composition; Be 0.5～15 by quality ratio; Especially preferred 1～10; Preferred especially 5～10, through mixing in this scope, can further improve the convergence effect when using and use after the convergence effect of persistence.
Composition for oral cavity of the present invention can be according to dosage form etc., as composition arbitrarily other known additives is mixed under the scope that does not hinder effect of the present invention must composition except above-mentioned.For example, the situation of toothpaste can mixed-abrasive, adhesion agent, binding agent, surfactant and sweeting agent as required, antiseptic, effective ingredient, pigment, spice etc., can these compositions and water be mixed with the usual way manufacturing.
As grinding agent, silicic acid anhydride, silica gel, aluminium silicate, Zirconium orthosilicate. (zirconosilicate), calcium hydrogen phosphate 2 hydrates, calcium hydrogen phosphate 2 no hydrates, calcium pyrophosphate, aluminium hydroxide, aluminium oxide, titanium dioxide, crystallinity silicic acid zirconium, polymethyl methacrylate, insoluble Metaphosphoric acid, precipitated calcium carbonate, ground calcium carbonate, magnesium carbonate, three alkali formula magnesium phosphate, zeolite, Zirconium orthosilicate., hydroxyapatite, fluoro apatite, the damaged apatite of calcium, three alkali calcium phosphates, four alkali calcium phosphates, eight alkali calcium phosphates, synthetic resin based abrasive etc. (usually combined amount 2～50%, especially 10～40%) are arranged for example.
As adhesion agent, can use more than a kind or 2 kinds (combined amount 5～50% usually) of polyhydric alcohol such as Polyethylene Glycol, ethylene glycol, reduction starch saccharification thing etc. of glycerol, sorbitol, propylene glycol, molecular weight 200～6000.
As binding agent, the inorganic binder etc. (combined amount 0～5%, especially 0.1～3%) usually of the organic binder bond, montorillonite clay, Kaolin, bentonite etc. of sodium polyacrylate, xanthane glue, sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, hydroxyethyl-cellulose, carbopol (carbopols), guar gum, gelatin, microcrystalline Cellulose etc. can be arranged for example.
As surfactant; As anion surfactant; For example just like sodium lauryl sulfate, sodium lauroyl sarcosine, laureth sulfate, N-lauroyl taurate, α-Xi Jihuangsuanyan etc.; As amphoteric surfactant; N-acyl glutamate, 2-alkyl-N-carboxyl methyl-N-hydroxyethyl imidazoles (imidazolinium) betanin etc. are arranged for example, as non-ionic surface active agent, for example just like alkyl polyglucoside, sucrose fatty acid ester, alkylolamides, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxy propylene glycol, polyoxyethylene alkyl ether, lauric acid Tricaprin etc. (combined amount 0.1～3%, especially 0.5～2%) usually.
As sweeting agent; Saccharin sodium, aspartame, stevioside, Steelvia chrysanthemum extract, p-met hoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine etc. are arranged for example; As antiseptic, p-Hydroxybenzoate (to the Para Hydroxy Benzoic Acid ester), sodium benzoate of butyl p-hydroxybenzoate, ethylparaben etc. etc. are arranged for example.
As effective ingredient, can have for example the chelating property phosphate cpd, copper gluconate etc. of the water-soluble phosphorus acid compound, tranexamic acid (tranexamic acid), EACA, allantoin chloro hydroxy Al, chamenol, ascorbic acid, acetic acid dl-tocopherol, dihydrocholesterol, α-bisabolol, chlorhexidine salt class, azulene, glycyrrhetin (glycyrrhetin), enoxolone (glycyrrhetinic acid), copper chlorobium chlorophyll sodium, chlorophyll, phosphoglycerol etc. of the fluoride of sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, single sodium monofluorophosphate etc., ortho-phosphoric potassium salt, sodium salt etc. copper compound, strontium chloride, potassium nitrate, hydroxyoxime acid and derivant thereof, sodium tripolyphosphate, zeolite, methoxy-ethylene, epidihydrocholesterol, zephiran chloride ammonium, dihydrocholesterol, trichlorine diphenylurea, zinc citrate, the soft extract of eastern Radix Angelicae Sinensis, Cortex Phellodendri extract, Chamomile, Flos Caryophylli, Herba Rosmarini Officinalis, the extract etc. of Radix Scutellariae, Flos Carthami etc.Also have, these mixing active ingredients amounts are set at effective dose in the scope that does not hinder effect of the present invention.
As spice; Can mix natural perfume material such as Oleum menthae, Oleum Menthae Rotundifoliae, Oleum Anisi Stellati, oil of wintergreen, Oleum Cinnamomi, Oleum Caryophylli, hundred li grass oil, sage oil, Fructus Citri Limoniae oil, orange-seed oil, Oleum menthae, cardamom oil, Fructus Coriandri oil, Pericarpium Citri Reticulatae oil, lime oil, Essential lavender oil, oil of rosemary, laurel fat, chamomile oil, caraway oil, marjoram oil, cassia oil, Indian oil of verbena, Herba Origani oil, pine needle oil, orange blossom oil, attar of roses, Jasmin oil, concrete of iris oil, Herba Menthae quintessence oil, Flos Rosae Multiflorae quintessence oil, Fructus Citri tangerinae caul-fat and these natural perfume materials processed (preceding heat up in a steamer portion, after heat up in a steamer portion, fractional distillation, liquid-liquid extraction, refiningization, powder perfumeization) spice of mistake and menthol, carboxylic acid, anethole, eucalyptole, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-glycol, thymol, Linalool (linalool), linalyl acetate, limonene, menthone, acetic acid menthyl ester, N-replace-to the list article spice of terpane-3-carboxylic acid amides, pinene, octanal, citral, pulegone, carvacryl acetate, acetic acid Fructus Foeniculi ester, ethyl acetate, ethyl n-butyrate., allyl cyclohexane propionic ester, methyl 2-aminobenzoate, glycidyl methyl phenyl ethyl ester, vanillin, decalactone, hexanal, propanol, butanols, isoamyl alcohol, hexanol, dimethylsulphide, ring dulcin, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, acetic acid ethylenebis dithiocarbamate ester etc., can also give an example like the mediation spice of strawberry flavor, apple spice, Fructus Musae spice, Fructus Ananadis comosi spice, grape flavor, Fructus Mangifera Indicae spice, butter spice, milk spice, fruit potpourri, tropical fruit (tree) spice etc. etc., be used for the known perfume base of composition for oral cavity.
The combined amount of spice does not have special qualification yet, and above-mentioned perfume base preferably uses 0.000001～1% in preparation is formed.In addition, used the tax perfume (or spice) of above-mentioned perfume base preferably in preparation is formed, to use 0.1～2.0% with spice.
As coloring agent, can illustration blue No. 1, yellow No. 4, green No. 3 etc.
Taking in the material of the container of composition for oral cavity of the present invention does not have special qualification, can use the container that is generally used for composition for oral cavity.Particularly, can use the plastic containers etc. of polyethylene, polypropylene, PETG, nylon etc.
Embodiment
Below, demonstrate experimental example, embodiment and comparative example, the present invention more specifically is described, but the present invention is not limited by following embodiment.Also have, combined amount all is quality % in following example.
[experimental example]
The dentifrice composition of forming shown in the modulomenter 1 (toothpaste) carries out following evaluation.The result shows at table 1.
(1) modulation of test dentifrice composition
With the dentifrice composition of forming shown in the following method modulomenter 1, (fill 50g among low density polyethylene (LDPE) 72 μ m/ ethylene acrylic acid co polymer resins 90 μ m/ aluminum 10 μ m/ ethylene acrylic acid co polymer resins 35 μ m/ straight chain shape low density polyethylene (LDPE)s 50 μ m, the thickness 257 μ m (society of Dai Nippon Printing (strain) manufacturing) at the diameter 26mm that innermost layer is made up of straight chain shape low density polyethylene (LDPE), the laminated tube of bore 8mm.
The modulation dentifrice composition has used aluminium potassium sulfate (potassium alum, big bright chemical industry (strain)), dry aluminium potassium sulfate (burnt alum, big bright chemical industry (strain)), Burnt ammonium alum (ammonia-alum, big bright chemical industry (strain)) sodium chloride (selected superfine salt, Japanese sea water (strain)).About other compositions, aluctyl., citric acid monohydrate compound, sodium hydroxide, dibastic sodium phosphate, sodium lauryl sulfate, silicic acid anhydride, titanium oxide, Macrogol 4000, sodium carboxymethyl cellulose, polyoxyethylene (20) hardened castor oil, saccharin sodium, D-sorbitol solution, propylene glycol, Purified Water have used the standard substance of cosmetic material benchmark, single fluoro sodium phosphate to use the standard substance of medicine part outer article raw material standard.
(i) the convergence sense in the use
With 10 of testees; About 1g sample (test dentifrice composition) is placed on the commercially available toothbrush; Carry out brushing teeth in 3 minutes, the convergence sense in using was obtained answering with " sensation consumingly ", " sensation ", " sensation a little ", " completely without sensation " 4 stages.In this was answered, " sensation consumingly " was that 4 minutes, " sensation " are that 3 minutes, " sensation a little " are that 2 minutes, " completely without feeling " are 1 minute.Estimate with following benchmark from 10 average marks.
◎: average mark is more than 3.5 minutes, below 4.0 minutes
Zero: average mark more than 3.0 minutes, less than 3.5 minutes
△: average mark more than 2.0 minutes, less than 3.0 minutes
*: average mark more than 1.0 minutes, less than 2.0 minutes
Convergence sense after (ii) using during through 5 minutes
With 10 of testees; About 1g sample (test dentifrice composition) is placed on the commercially available toothbrush; Carry out brushing teeth in 3 minutes, the convergence sense during through 5 minutes after using is obtained answer with " sensation consumingly ", " sensation ", " sensation a little ", " completely without sensation " 4 stages.In this was answered, " sensation consumingly " was that 4 minutes, " sensation " are that 3 minutes, " sensation a little " are that 2 minutes, " completely without feeling " are 1 minute.Estimate with following benchmark from 10 average marks.
◎: average mark is more than 3.5 minutes, below 4.0 minutes
Zero: average mark more than 3.0 minutes, less than 3.5 minutes
△: average mark more than 2.0 minutes, less than 3.0 minutes
*: average mark more than 1.0 minutes, less than 2.0 minutes
(iii) restrain the persistent period of effect
With 10 of testees, about 1g sample (test dentifrice composition) is placed on the commercially available toothbrush, carry out brushing teeth in 3 minutes, instrumentation is felt and time of the convergence effect after using has been shown average time.
Metallic taste in (iv) using
With 10 of testees; About 1g sample (test dentifrice composition) is placed on the commercially available toothbrush; Carry out brushing teeth in 3 minutes, the metallic taste in using was obtained answering with " sensation consumingly ", " sensation ", " sensation a little ", " completely without sensation " 4 stages.In this was answered, " completely without sensation " was that 4 minutes, " sensation a little " are that 3 minutes, " sensation " are that 2 minutes, " feeling consumingly " are 1 minute.Estimate with following benchmark from 10 average marks.
◎: average mark is more than 3.5 minutes, below 4.0 minutes
Zero: average mark more than 3.0 minutes, less than 3.5 minutes
△: average mark more than 2.0 minutes, less than 3.0 minutes
*: average mark more than 1.0 minutes, less than 2.0 minutes
[table 1]
Can know from the result of table 1, in any of (a) and (b) composition for do not have to mix forming or combined amount of these compositions is in the composition beyond the scope of the invention, the convergence sense in the use is poor with its persistence, or use in metallic taste strong, usability is poor.And and used (a) and (b) composition composition for oral cavity of the present invention oneself be identified: in use bring into play higher convergence effect, the persistence of its effect is also excellent, and can not feel the metallic taste that derives from polyvalent metal, and usability is also excellent.
Then, modulate the composition for oral cavity of following composition, estimate equally, results verification in use all bring into play higher convergence effect, also bring into play higher persistence after the use, can not feel simultaneously metallic taste, and usability is also excellent.
[table 2]
[embodiment 8] toothpaste
Aluminium potassium sulfate 1.0%
Sodium chloride 5.0
Isopropyl methyl phenol 0.1
Sodium lauroyl sarcosine 0.2
Tocopheryl acetate 0.1
Sodium lauryl sulfate 1.0
Spice 1.2
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers (triclosan) 0.03
Polyoxyethylene (20) hardened castor oil 1.8
Silicic acid anhydride 20
Sodium polyacrylate 0.8
Xanthane glue 0.5
D-sorbitol solution (70%) 35
Saccharin sodium 0.2
Propylene glycol 3.0
Methyl parahydroxybenzoate 0.05
Butyl p-hydroxybenzoate 0.01
Titanium oxide 0.4
Sodium fluoride 0.21
The water surplus
Meter 100.0%
The mass ratio of sodium chloride/aluminium potassium sulfate: 5.0
[table 3]
[embodiment 9] toothpaste
Aluminium potassium sulfate 1.0%
Sodium chloride 10
Isopropyl methyl phenol 0.1
Sodium lauroyl sarcosine 0.2
Tocopheryl acetate 0.1
Allantoin 0.05
Enoxolone 0.02
Sodium lauryl sulfate 1.0
Spice 1.2
Polyoxyethylene (20) hardened castor oil 1.5
Silicic acid anhydride 20
Sodium carboxymethyl cellulose 1.0
Xanthane glue 0.2
D-sorbitol solution (70%) 35
Saccharin sodium 0.2
Propylene glycol 3.0
Methyl parahydroxybenzoate 0.05
Butyl p-hydroxybenzoate 0.01
Titanium oxide 0.4
Sodium fluoride 0.21
The water surplus
Meter 100.0%
The mass ratio of sodium chloride/aluminium potassium sulfate: 10.0
[table 4]
[embodiment 10] aqueous toothpaste
Aluminium potassium sulfate 2.0%
Sodium chloride 5.0
Isopropyl methyl phenol 0.1
Tocopheryl acetate 0.1
Zeolite 1.0
Sodium lauryl sulfate 1.5
Spice 1.2
Polyoxyethylene (20) hardened castor oil 1.2
Sodium polyacrylate 0.3
Sodium alginate 0.4
D-sorbitol solution (70%) 55
Saccharin sodium 0.2
Propylene glycol 3.0
Methyl parahydroxybenzoate 0.05
Butyl p-hydroxybenzoate 0.01
Sodium fluoride 0.21
The water surplus
Meter 100.0%
The mass ratio of sodium chloride/aluminium potassium sulfate: 2.5
[table 5]
[embodiment 11] collutory
Aluminium potassium sulfate 1.0%
Sodium chloride 5.0
Ethanol 10
Glycerol 10
D-sorbitol solution (70%) 5.0
Sodium lauryl sulfate 0.2
Spice 0.3
Polyoxyethylene (60) hardened castor oil 3.0
Saccharin sodium 0.05
Methyl parahydroxybenzoate 0.15
The water surplus
Meter 100.0%
The mass ratio of sodium chloride/aluminium potassium sulfate: 5.0
Claims (4)
1. composition for oral cavity; It is characterized in that; Contain: (a) be selected from the aluminium compound of aluminium potassium sulfate, Burnt ammonium alum a kind or 2 kinds and (b) sodium chloride, the combined amount of said (a) composition is 0.3～2 quality %, and the combined amount of said (b) composition is 0.2～10 quality %; With respect to said (a) composition, containing is said (b) composition of 5～10 ratio by quality ratio.
2. like the composition for oral cavity of claim 1 record, be modulated to toothpaste.
3. the convergence raising method of a composition for oral cavity; It is characterized in that; Said composition for oral cavity is to contain the composition for oral cavity that (a) is selected from the aluminium compound of aluminium potassium sulfate, Burnt ammonium alum a kind or 2 kinds, in said composition for oral cavity, mixes in said (a) aluminium compound of 0.3～2 quality %, and with (b) sodium chloride of 0.2～10 quality %; With respect to said (a) composition, mixing is said (b) composition of 5～10 ratio by quality ratio.
4. like the convergence raising method of claim 3 record, said method is to improve the constringent method of dentifrice composition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007-236244 | 2007-09-12 | ||
| JP2007236244 | 2007-09-12 | ||
| PCT/JP2008/066037 WO2009034919A1 (en) | 2007-09-12 | 2008-09-05 | Oral composition and method of improving astringency of oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101801334A CN101801334A (en) | 2010-08-11 |
| CN101801334B true CN101801334B (en) | 2012-10-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801071863A Active CN101801334B (en) | 2007-09-12 | 2008-09-05 | Oral composition and method of improving astringency of oral composition |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5310556B2 (en) |
| KR (1) | KR101527243B1 (en) |
| CN (1) | CN101801334B (en) |
| WO (1) | WO2009034919A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5573111B2 (en) * | 2009-11-06 | 2014-08-20 | ライオン株式会社 | Isopropylmethylphenol-containing liquid oral composition |
| JP6142316B2 (en) * | 2011-12-16 | 2017-06-07 | 奥野製薬工業株式会社 | Method for improving taste of inorganic metal salt, method for producing food additive, and food additive |
| CN103436362A (en) * | 2013-08-16 | 2013-12-11 | 德利宝(广州)香料有限公司 | Essence with natural grape extract and preparation method of toothpaste |
| US10098820B2 (en) | 2013-12-11 | 2018-10-16 | Colgate-Palmolive Company | High salt toothpaste with stable viscosity |
| CN103830149B (en) * | 2014-03-24 | 2016-03-30 | 刘梅 | A kind of disinfection of Chinese drug collutory and preparation method thereof |
| JP6409618B2 (en) * | 2015-02-26 | 2018-10-24 | ライオン株式会社 | Dentifrice composition |
| JP6540366B2 (en) * | 2015-08-21 | 2019-07-10 | ライオン株式会社 | Toothpaste composition |
| CN108969413A (en) * | 2017-06-05 | 2018-12-11 | 狮王株式会社 | Composition for oral cavity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679493A (en) * | 2005-01-18 | 2005-10-12 | 崔青山 | Natural and whitening tooth powder and production thereof |
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| JPS59157014A (en) * | 1983-02-25 | 1984-09-06 | Nippon Zeora Kk | Dentifrice |
| JP3346586B2 (en) * | 1991-08-29 | 2002-11-18 | 富山化学工業株式会社 | Pharmaceutical composition containing pyridonecarboxylic acid or salt thereof and method for stabilizing solution of pyridonecarboxylic acid or salt thereof |
| US5635162A (en) * | 1995-02-23 | 1997-06-03 | Ultradent Products, Inc. | Hemostatic composition for treating gingival area |
| KR100550066B1 (en) * | 2002-12-31 | 2006-02-08 | 주식회사 태평양 | Patch kit comprising the water-soluble adhesive solution and the patch containing water-soluble adhesive layer, and a method for dental-whitening by using thereof |
| JP4918973B2 (en) * | 2005-08-12 | 2012-04-18 | ライオン株式会社 | Dentifrice composition |
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- 2008-09-05 CN CN2008801071863A patent/CN101801334B/en active Active
- 2008-09-05 JP JP2009532160A patent/JP5310556B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2009034919A1 (en) | 2010-12-24 |
| KR20100067095A (en) | 2010-06-18 |
| WO2009034919A1 (en) | 2009-03-19 |
| JP5310556B2 (en) | 2013-10-09 |
| CN101801334A (en) | 2010-08-11 |
| KR101527243B1 (en) | 2015-06-08 |
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