CN105658194A - Tooth paste composition - Google Patents
Tooth paste composition Download PDFInfo
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- CN105658194A CN105658194A CN201480058002.4A CN201480058002A CN105658194A CN 105658194 A CN105658194 A CN 105658194A CN 201480058002 A CN201480058002 A CN 201480058002A CN 105658194 A CN105658194 A CN 105658194A
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- oil
- dentrifice composition
- sodium
- hyperesthesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
Provided is a tooth paste composition that has an effect of suppressing hyperesthesia at an early stage and thus exerts an excellent effect of suppressing and treating hyperesthesia while giving a good feel of use, said tooth paste composition comprising (A) a sodium alpha-olefin sulfonate and (B) sodium lauryl sulfate, wherein the ratio by mass of (A) to (B) (A/B) is 0.3-3.
Description
Technical field
The present invention relates to Dentrifice composition.
Background technology
Hyperesthesia (dentin acroesthesia) refers to that enamel or cementum disappear and expose dentin, the transient very offending pain that the dentin exposed produces owing to being subject to temperature, chemical or mechanical external irritant. It is conducted to nerve via dentinal tubule it is now recognized that the reason of pain is external irritant and causes.
As relating to suppressing hypersensitive technology by dental health products such as dentifrices, it is known that have the method closing dentinal tubule and the neural method of paralysis.
As close dentinal tubule method, it is known that such as have use aluctyl. method. Aluctyl. has the effect of blocking Dentinal tubules, also has the astriction to gingiva (patent documentation 1,2) simultaneously.
As the method that paralysis is neural, it is known that have the method (patent documentation 3,4) using the potassium salt such as potassium nitrate.
Prior art literature
Patent documentation
Patent documentation 1: Japanese Patent Laid-Open 7-291844 publication
Patent documentation 2: Japanese Patent Laid-Open 2003-26556 publication
Patent documentation 3: Japanese Patent Laid-Open 2003-73246 publication
Patent documentation 4: Japan Patent spy's table 2004-506663 publication
Summary of the invention
Invent problem to be solved
But present situation is, even if making in aforementioned manners, it usually needs the time of more than one month reduces, eliminates pain, send out patient's simultaneous therebetween painful. Particularly when having hyperesthesia symptom, pain can be felt during owing to brushing teeth, therefore generally brush teeth difficulty, can not fully remove the dental surface dirt such as attachment and the spot of deposition, dental plaque, food debris, ree-oil on dental surface, thus also existing keeping oral hygiene to bring dysgenic problem. Therefore, it is intended that exploitation one can suppress hyperesthesia symptom in early days, excellent and Dentrifice composition that use sense is also good in the suppression and therapeutic effect of hyperesthesia symptom.
In view of the foregoing, its problem is in that to provide a kind of Dentrifice composition to the present invention, its by there is early stage hyperesthesia inhibition and in the suppression and therapeutic effect of hyperesthesia symptom excellence and use sense also good.
Solve the means of problem
The present invention provides following (1)��(3).
(1) a kind of Dentrifice composition, it contains potassium nitrate, (A) ��-sodium olefin sulfonate and (B) sodium lauryl sulfate, and the A mass ratio (A/B) relative to B is 0.3��3.
(2) according to the Dentrifice composition described in (1), it contains Polyethylene Glycol further.
(3) according to the Dentrifice composition described in (1) or (2), it is dentifrice composition.
Invention effect
According to the present invention it is possible to provide a kind of start to brush teeth while just can produce neural paralysis effect and the Dentrifice composition of promptly sensigenous allergy inhibition. Additionally, the present invention by comprising Polyethylene Glycol further in this Dentrifice composition, it is also possible to the Dentrifice composition that clearly sense is also good after providing the suppression being not only advantageous for acroesthesia or relaxing and brush teeth.
Detailed description of the invention
Hereinafter, the present invention is described in detail.
" hyperesthesia inhibition " in this specification refers to the effect suppressing the outbreak of hyperesthesia symptom.
In addition, " early stage hyperesthesia inhibition " in this specification refers at least after start to brush teeth (brushing) 1 minute, after starting to brush teeth 30 seconds, more preferably from after starting to brush teeth 10 seconds, most preferably from after just starting to brush teeth, just producing to suppress the effect of hyperesthesia symptom outbreak.
One mode of the Dentrifice composition of the present invention contains potassium nitrate, (A) ��-sodium olefin sulfonate and (B) sodium lauryl sulfate, and the A mass ratio (A/B) relative to B is 0.3��3.
The A in the Dentrifice composition of the present invention mass ratio (A/B) relative to B is generally 0.3��3, but preferably 0.3��2, and more preferably 0.5��1. A/B is less than above-mentioned scope, and hyperesthesia inhibition produces slow sometimes, additionally, A/B is more than above-mentioned scope, greasy feeling enhancing sometimes etc. is thus use sense is deteriorated.
The combined amount of potassium nitrate in the Dentrifice composition of the present invention is not particularly limited, but relative to the Dentrifice composition total amount of the present invention, it is preferable that 0.1��7 mass %, more preferably 0.5��5 mass %. The combined amount of potassium nitrate is very few, sometimes can not abundant sensigenous allergy inhibition, additionally, the combined amount of potassium nitrate is too much, metallic taste strengthens thus use sense is deteriorated sometimes.
The combined amount of (A) ��-sodium olefin sulfonate in the Dentrifice composition of the present invention is not particularly limited, but relative to the Dentrifice composition total amount of the present invention, it is preferable that 0.5��2 mass %, more preferably 0.75��1.5 mass %. The combined amount of ��-sodium olefin sulfonate is very few, and hyperesthesia inhibition produces slow sometimes, additionally, the combined amount of ��-sodium olefin sulfonate is too much, greasy feeling enhancing sometimes etc. is thus use sense is deteriorated.
��-the sodium olefin sulfonate that carbon number is 10��16 of the preferred alkyl chain carbochain of ��-sodium olefin sulfonate in the present invention.
The combined amount of sodium lauryl sulfate in the Dentrifice composition of the present invention is not particularly limited, but relative to the Dentrifice composition total amount of the present invention, it is preferable that 0.5��3 mass %, more preferably 0.75��2.5 mass %. The combined amount of sodium lauryl sulfate is very few, and hyperesthesia inhibition produces slow sometimes, additionally, the combined amount of sodium lauryl sulfate is too much, sometimes produces mucosa stripping etc. thus use sense is deteriorated.
More preferably the mode of the Dentrifice composition of the present invention is except above-mentioned three kinds of compositions, possibly together with Polyethylene Glycol. By containing Polyethylene Glycol in Dentrifice composition, it is possible to improve the salubrious sense of Dentrifice composition.
The molecular weight of the Polyethylene Glycol in the Dentrifice composition of the present invention is not particularly limited, but preferably 1000��10000, more preferably 3000��5000. The molecular weight of Polyethylene Glycol, less than or greater than above-mentioned scope, can not fully improve salubrious sense sometimes.
The combined amount of Polyethylene Glycol in the Dentrifice composition of the present invention is not particularly limited, but relative to the Dentrifice composition total amount of the present invention, it is preferable that 0.1��3 mass %, more preferably 0.3��1 mass %. The combined amount of Polyethylene Glycol, more or less than above-mentioned scope, can not fully improve salubrious sense sometimes.
Owing to the Dentrifice composition of the present invention has early stage hyperesthesia inhibition, it is thus preferred to for hyperesthesia patient but it also may be prophylactically used for preventing hyperesthesia from showing effect.
Form and dosage form to the Dentrifice composition of the present invention are not particularly limited. Such as can be formulated as the various forms such as liquid system (liquid, aqueous, pasty state), solid system (solid, solid fraction).As the example of dosage form, for example there are the Dentrifice compositions such as toothpaste, liquid dentifrice, aqueous dentifrice, toothpaste powder. Wherein, the preferred dentifrice composition of the Dentrifice composition of the present invention.
In the scope not interfering with effect of the present invention, except above-mentioned each composition, the Dentrifice composition of the present invention can also suitably mix any composition known in the manufacture of Dentrifice composition. As any composition, such as example there are grinding agent, binding agent, adhesion agent (wetting agent), surfactant, sweeting agent, preservative, spice, medicinal ingredient, coloring agent, pH adjusting agent, solvent, excipient, it is possible to suitably select according to dosage form. The concrete example of any composition given below, but any composition that may be combined in the Dentrifice composition of the present invention is not limited thereto.
As grinding agent, for instance for example there are the silicon dioxide based abrasives such as silicic acid anhydride, crystalline silica, non-crystalline silica, silica gel, aluminium silicate, zeolite, calcium hydrogen phosphate anhydride, dicalcium phosphate dihydrate, calcium pyrophosphate, calcium carbonate, aluminium hydroxide, aluminium oxide, magnesium carbonate, tricresyl phosphate magnesium, Zirconium orthosilicate., tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, synthetic resin grinding agent etc. Wherein, from the view point of bubble, it is preferable that silicon dioxide based abrasive. Grinding agent can be used alone one or combination uses two or more. Combined amount when being mixed into grinding agent is preferably 2��40 mass % of Dentrifice composition total amount, more preferably 5��20 mass %.
As binding agent, for instance for example there are pulullan polysaccharide, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, arabic gum, guar gum, locust bean gum, polyvinyl alcohol, polyvinylpyrrolidone, CVP Carbopol ETD2050 etc. Binding agent can be used alone one or combination uses two or more. Using combined amount during binding agent to be commonly angled relative to Dentrifice composition total amount is 0.01��3 mass %.
As adhesion agent (wetting agent), for instance for example there are Sorbitol, propylene glycol, butanediol, glycerol etc. Adhesion agent can be used alone one or combination uses two or more. Using combined amount during adhesion agent can determine in the scope not interfering with effect of the present invention, being commonly angled relative to Dentrifice composition total amount is 1��60 mass %.
As surfactant, for instance for example there are anion surfactant, nonionic surfactant etc.
As anion surfactant, for instance for example there are the sulfate etc. of N-acyl amino hydrochlorate, N-acyl group sulfonate, alkyl sulfate, fatty acid glyceride. Wherein, from versatility aspect, it is preferable that N-acyl amino hydrochlorate, alpha-alkene sulfonate, alkyl sulfate etc., from foaminess and stability in hard water aspect, more preferably sodium lauroyl sarcosine, sodium lauryl sulfate etc.
As nonionic surfactant, for instance for example there are polyoxyethylene alkyl ether, polyox-yethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated Oleum Ricini, the polyoxyethylene ether of glyceride, sucrose fatty acid ester, alkanolamide, fatty acid glyceride etc. Wherein, from versatility aspect, it is suitable for using polyoxyethylene alkyl ether, polyoxyethylene hydrogenated Oleum Ricini, alkanolamide, Span etc. The carbon chain length of polyoxyethylene alkyl ether alkyl chain is preferably 14��18 in carbon number.The average addition molal quantity of ethylene oxide of polyoxyethylene alkyl ether is preferably 15��30. The ethylene oxide average addition molal quantity (average addition EO) of polyoxyethylene hydrogenated Oleum Ricini is preferably 20��100. The carbon chain length carbon number of alkanolamide alkyl chain is preferably 12��14. The fatty acid carbon atoms number of Span is preferably 12��18. The fatty acid carbon atoms number of Polyoxyethylene Sorbitol Fatty Acid Esters is preferably 16��18. Additionally, the average addition molal quantity of the ethylene oxide of Polyoxyethylene Sorbitol Fatty Acid Esters is preferably 10��40.
When using surfactant, it is possible to be used singly or in combination of two or more kinds. Using combined amount during surfactant to be commonly angled relative to Dentrifice composition total amount is 0��10 mass %, it is preferable that 0.01��5 mass %.
As sweeting agent, for instance for example there are saccharin sodium, stevioside, neohesperidin dihydrochalcone, glycyrrhizic acid, perillartine, p-met hoxycinnamic aldehyde, Talin, palatinose, maltose alcohol, xylitol, 1,2,3,4,5-pentanepentol etc. When using sweeting agent, it is possible to be used singly or in combination of two or more kinds. When using sweeting agent, its combined amount suitably can be determined in the scope not damaging effect of the present invention.
As preservative, for instance can p-Hydroxybenzoate, editic acid salt, the benzalkonium chloride etc. such as benzene mixed sodium formate, methyl parahydroxybenzoate, ethylparaben, butyl p-hydroxybenzoate. When using preservative, it is possible to be used singly or in combination of two or more kinds. These compositions can mix with usual consumption in the scope not damaging effect of the present invention.
As spice, for instance for example there are natural perfume material, synthetic perfume (single spice), be in harmonious proportion spice (oils and fats spice (oily perfume), powder perfume etc.), it is possible to use one or more in these.
As natural perfume material, such as example there are Olibanum oil, parsley oil, oleum anisi, eucalyptus oil, wintergreen oil, Oleum Cinnamomi, menthol oil, oleum menthae viridis, Oleum menthae, Fructus Citri Limoniae oil, Fructus Coriandri oil, orange-seed oil, mandarin oil, lime oil, Oleum lavandula angustifolia, laurel fat, chamomile oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, orange blossom oil, attar of roses, Jasmin oil, flag flower extractum, Peppermint essential oil, Flos Rosae Multiflorae quintessence oil, Citrus flower, tangerine oil, mixing water fruit oil, Fructus Fragariae Ananssae oil, Ceylon cinnamon oil, Oleum Caryophylli, grapefruit, thyme oil, sage oil, Oleum menthae, oil of rosemary, Majorana hortensis oil, Herba Origani oil, oil of grapefruit, tangerine oil (sweetieoil), Fructus Citri grandis wet goods.
As single spice, such as example there are carvone, anethole, methyl salicylate, cinnamic aldehyde, linalool, linalyl-acetate, limonene, menthone, menthyl acetate, sobrerone, octanal, citral, pulegone, carvacryl acetate, anisaldehyde, ethyl acetate, ethyl n-butyrate., hexamethylene propylene carbonate, methyl 2-aminobenzoate, ortho-aminobenzoic acid ethyl methyl ester, vanilione, undecalactone, hexanal, ethanol, propanol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, bran aldehyde, trimethylpyrazine, ethyl lactate, ethyl thioacetate, eucalyptole, eugenol etc.
As being in harmonious proportion spice, it is single spice and/or the spice of natural perfume material mediation, for instance for example there are STOL spice, Fructus Fragariae Ananssae perfume, Fructus Mali pumilae perfume, banana incense, Fructus Ananadis comosi perfume, Fructus Vitis viniferae perfume, Fructus Mangifera Indicae perfume, tropical fruit (tree) perfume, butter perfume, milk, Yoghourt are fragrant, fruit mixing is fragrant, brisbane pennyroyal is fragrant.
The form of spice is not limited, it is possible to be quintessence oil, extract, solids or by any one in the powder body of these any one spray drying.
The above-mentioned spice of 0.1��2 mass % is used preferably in preparation in forming.
As medicinal ingredient, for instance for example there are following component: fluorides such as sodium monofluorophosphate, sodium fluoride, stannous fluoride, strontium fluorides; Sterilization or the antibacterial such as chlorhexidine, triclosan, isopropyl methyl phenol, cetylpyridinium chloride, zinc gluconate, zinc citrate; The tartar preventing agents such as condensed phosphate, ethanehydroxy diphosphate; The antiinflammatory such as tranamic acid, glycyrrhizic acid dipotassium salt, episilon amino caproic acid, Cortex Phellodendri extract; The coating agents such as hydroxyethyl cellulose dimethyl diallyl ammonium chloride; The astringents such as allantoin aluminium chlorhydroxide, vitamin C, lysozyme chloride, enoxolone and its esters, sodium chloride, allantoin; The hyperesthesia inhibitor etc. such as strontium chloride. Use combined amount during medicinal ingredient can be respectively directed in each medicinal ingredient pharmaceutically acceptable scope suitably to set.
As coloring agent, for instance the natural pigment such as safflower red pigment, Gardenia Yellow, gardenia blue pigment, Perilla color, monascorubin, deodorized red cabbage color, Radix Dauci Sativae pigment, Hibiscus syriacus L. pigment, cacao color, spirulina blue color, tamarind pigment can be used; The legal dyestuffs such as redness 3, redness 104, redness 105, redness 106, yellow 4, Sunset Yellow FCF, green 3, blueness 1; Riboflavin, chlorophyll copper sodium, titanium dioxide etc. When being mixed into coloring agent, its combined amount is preferably 0.00001��3 mass % relative to Dentrifice composition total amount.
Considering use sense or the impacts on tooth decalcification such as oral mucosa stimulation, the pH of the Dentrifice composition of the present invention is generally 6��10, more preferably the general context of pH7��9. As pH adjusting agent, for instance for example there are acid or alkali, the buffer agents such as acetic acid, hydrochloric acid, sulphuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, natrium hydrocitricum, sodium phosphate, sodium dihydrogen phosphate. Use combined amount during pH adjusting agent suitably can determine in the scope not damaging effect of the present invention.
As solvent, for instance for example there are water and the carbon number such as ethanol, propanol lower alcohol below 3. Solvent is generally allocated in the Dentrifice composition of liquid system. When being mixed into solvent, the combined amount that solvent is during water is preferably 20��95 mass % relative to Dentrifice composition total amount. The combined amount that solvent is during lower alcohol is preferably 1��20 mass % relative to Dentrifice composition total amount.
As excipient, for instance for example there are syrup, glucose, fructose, Nulomoline, dextrin, oligosaccharide etc. Combined amount when being mixed into excipient suitably can be determined in the scope not damaging effect of the present invention.
Embodiment
Below, specifically describe the present invention by embodiment, but the present invention is not by the restriction of following embodiment. % in following example all represents quality percentage %.
The details of the primary raw material used is as follows:
Potassium nitrate: with Guang Chun medicine Co., Ltd. system;
��-sodium olefin sulfonate: Lion Corporation's system;
Sodium lauryl sulfate: Toho Chemical Industry Co., Ltd.'s system;
Polyethylene Glycol (molecular weight 4000): Sanyo Chemical Industries, Ltd.'s system;
Polyethylene Glycol (molecular weight 1000): Sigma-Aldrich company system;
Polyethylene Glycol (molecular weight 10000): Sigma-Aldrich company system.
(embodiment 1��11 and comparative example 1��5 (preparation of dentifrice composition))
(manufacture method of the dentifrice composition of embodiment 1��8 and comparative example 1��5)
1. under room temperature, in distilled water, mixed dissolution water soluble ingredient (except binding agent, propylene glycol) prepares A phase.
2. under room temperature, binding agent is scattered in propylene glycol and prepares B phase.
3. the A phase in stirring is added mixing B phase, prepares C phase.
4. use 1.5L kneader (tor work is made) mixing composition except the water soluble ingredient such as spice, grinding agent in C phase, (2666Pa) deaeration of reducing pressure under room temperature, obtain Dentrifice composition 1.2kg.
5. the Dentrifice composition of making is filled in 50g pipe, is used for testing.
(manufacture method of the dentifrice composition of embodiment 9��11 (being mixed into Polyethylene Glycol))
1. under room temperature, in distilled water, mixed dissolution contains water soluble ingredient (except binding agent, propylene glycol) the preparation A phase of Polyethylene Glycol.
2. under room temperature, binding agent is scattered in propylene glycol and prepares B phase.
3. the A phase in stirring is added mixing B phase, prepares C phase.
4. use 1.5L kneader (tor work is made) mixing composition except the water soluble ingredient such as spice, grinding agent in C phase, (2666Pa) deaeration of reducing pressure under room temperature, obtain Dentrifice composition 1.2kg.
5. the Dentrifice composition of making is filled in 50g pipe, is used for testing.
In the dentifrice composition obtained as mentioned above, according to tests below example, the dentifrice composition of embodiment 1��8 and the dentifrice composition of comparative example 1��6 are carried out the evaluation that hyperesthesia inhibition, metallic taste or greasy feeling and mucosa are peeled off in early days, the dentifrice composition of embodiment 9��11 is carried out early stage hyperesthesia inhibition, metallic taste or greasy feeling, mucosa stripping and the salubrious evaluation felt. Result is such as shown in table 1��3.
(test example)
It is called participant with hyperesthesia patient 10.
The dentifrice composition of preparation is extruded from tubular container, extrude about 1cm on toothbrush, based on following standards of grading and evaluation criterion, to early stage hyperesthesia inhibition during with generally the same brushing teeth 3 minutes, metallic taste or greasy feeling, mucosa peels off and salubrious sense is evaluated.
(1) hyperesthesia inhibition
Evaluate the pain in the ill district of hyperesthesia in brushing teeth.
The standards of grading of pain are recorded in (i), evaluation criterion is recorded in (ii).
(i) standards of grading
5 from after just starting to brush teeth, imperceptible pain
4 from after starting to brush teeth 10 seconds, imperceptible pain
3 from after starting to brush teeth 30 seconds, imperceptible pain
2 from after starting to brush teeth 1 minute, imperceptible pain
1 feels pain
(ii) evaluation criterion
The average mark of �� 10 people is more than 4.0 points
The average mark of 0 10 people is more than 3.0 points and less than 4.0 points
The average mark of �� 10 people is more than 2.0 points and less than 3.0 points
The average mark of �� 10 people is less than 2.0 points
(2) metallic taste or greasy feeling
Evaluate the metallic taste in brushing teeth and after brushing teeth or greasy feeling.
The standards of grading of metallic taste or greasy feeling are recorded in (i), evaluation criterion is recorded in (ii).
The standards of grading of (i) metallic taste or greasy feeling
5 is completely imperceptible
4 somewhat feel
3 feel
2 feel strongly
1 strongly feels
(ii) evaluation criterion of metallic taste or greasy feeling
The average mark of �� 10 people is more than 4.0 points
The average mark of 0 10 people is more than 3.0 points and less than 4.0 points
The average mark of �� 10 people is more than 2.0 points and less than 3.0 points
The average mark of �� 10 people is less than 2.0 points
(3) mucosa is peeled off
Evaluate the mucosa after brushing teeth to peel off.
The standards of grading that mucosa is peeled off are recorded in (i), evaluation criterion is recorded in (ii).
I standards of grading that () mucosa is peeled off
Standards of grading
5 entirely without generation
4 somewhat occur
3 occur
2 occur consumingly
1 strongly occurs
(ii) evaluation criterion that mucosa is peeled off
Standards of grading
The average mark of �� 10 people is more than 4.0 points
The average mark of 0 10 people is more than 3.0 points and less than 4.0 points
The average mark of �� 10 people is more than 2.0 points and less than 3.0 points
The average mark of �� 10 people is less than 2.0 points
(4) clearly feel
Evaluate the salubrious sense after brushing teeth.
The standards of grading of salubrious sense are recorded in (i), evaluation criterion is recorded in (ii).
The standards of grading of (i) clearly sense
5 is very good
4 is good
3 are difficult to evaluate
2 is poor
1 is excessively poor
(ii) evaluation criterion of salubrious sense
The average mark of �� 10 people is more than 4.0 points
The average mark of 0 10 people is more than 3.0 points and less than 4.0 points
The average mark of �� 10 people is more than 2.0 points and less than 3.0 points
The average mark of �� 10 people is less than 2.0 points
Table 1 (embodiment)
Table 2 (embodiment)
Table 3 (comparative example)
Comparative example 6 is owing to without surfactant, therefore bubbling excessively poor, and except metallic taste and greasy feeling, its use sense is poor. Specifically, preparation does not arrive each corner intraoral, and not only outwash sense is poor, and dental plaque is removed insufficient, weakens the basic function of toothpaste.
Claims (3)
1. a Dentrifice composition, it contains potassium nitrate, (A) ��-thiazolinyl sodium olefin sulfonate and (B) sodium lauryl sulfate, and the A mass ratio A/B relative to B is 0.3��3.
2. Dentrifice composition according to claim 1, it contains Polyethylene Glycol further.
3. Dentrifice composition according to claim 1 and 2, it is dentifrice composition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-222580 | 2013-10-25 | ||
| JP2013222580A JP6092751B2 (en) | 2013-10-25 | 2013-10-25 | Dentifrice composition |
| PCT/JP2014/078355 WO2015060426A1 (en) | 2013-10-25 | 2014-10-24 | Tooth paste composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105658194A true CN105658194A (en) | 2016-06-08 |
| CN105658194B CN105658194B (en) | 2019-03-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480058002.4A Active CN105658194B (en) | 2013-10-25 | 2014-10-24 | Dentrifice composition |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP6092751B2 (en) |
| KR (1) | KR101980563B1 (en) |
| CN (1) | CN105658194B (en) |
| MY (1) | MY179021A (en) |
| WO (1) | WO2015060426A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017094579A1 (en) * | 2015-11-30 | 2017-06-08 | ライオン株式会社 | Dentifrice composition and oral biofilm removing agent |
| MY191247A (en) * | 2015-11-30 | 2022-06-10 | Lion Corp | Oral composition |
| JP2017141178A (en) * | 2016-02-09 | 2017-08-17 | ライオン株式会社 | Dentifrice composition |
| US11071704B2 (en) * | 2017-12-27 | 2021-07-27 | Kao Corporation | Oral composition |
| JP7159850B2 (en) * | 2018-12-21 | 2022-10-25 | ライオン株式会社 | oral composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08175943A (en) * | 1994-12-22 | 1996-07-09 | Lion Corp | Composition for oral cavity |
| JP2005289917A (en) * | 2004-04-01 | 2005-10-20 | Lion Corp | Dentifrice composition |
| CN101938975A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Dual component oral care product |
| JP2013151474A (en) * | 2011-12-26 | 2013-08-08 | Lion Corp | Composition for oral cavity and oral cavity biofilm removing agent |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07291844A (en) | 1994-04-28 | 1995-11-07 | Sunstar Inc | Composition for oral cavity |
| CA2420154A1 (en) | 2000-08-21 | 2002-02-28 | Block Drug Company, Inc. | Dental composition for hypersensitive teeth |
| JP2003026556A (en) | 2001-07-11 | 2003-01-29 | Lion Corp | Tooth paste composition |
| JP2003073246A (en) | 2001-08-31 | 2003-03-12 | Sunstar Inc | Composition for oral cavity |
| JP5709639B2 (en) * | 2011-05-02 | 2015-04-30 | ライオン株式会社 | Oral composition |
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2013
- 2013-10-25 JP JP2013222580A patent/JP6092751B2/en active Active
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- 2014-10-24 CN CN201480058002.4A patent/CN105658194B/en active Active
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08175943A (en) * | 1994-12-22 | 1996-07-09 | Lion Corp | Composition for oral cavity |
| JP2005289917A (en) * | 2004-04-01 | 2005-10-20 | Lion Corp | Dentifrice composition |
| CN101938975A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Dual component oral care product |
| JP2013151474A (en) * | 2011-12-26 | 2013-08-08 | Lion Corp | Composition for oral cavity and oral cavity biofilm removing agent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105658194B (en) | 2019-03-29 |
| KR20160068724A (en) | 2016-06-15 |
| MY179021A (en) | 2020-10-26 |
| JP2015083556A (en) | 2015-04-30 |
| KR101980563B1 (en) | 2019-05-21 |
| JP6092751B2 (en) | 2017-03-08 |
| WO2015060426A1 (en) | 2015-04-30 |
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