CN105658194B - Dentrifice composition - Google Patents
Dentrifice composition Download PDFInfo
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- CN105658194B CN105658194B CN201480058002.4A CN201480058002A CN105658194B CN 105658194 B CN105658194 B CN 105658194B CN 201480058002 A CN201480058002 A CN 201480058002A CN 105658194 B CN105658194 B CN 105658194B
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- dentrifice composition
- oil
- hyperesthesia
- dentrifice
- composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention provides a kind of Dentrifice composition, its excellent and use feeling in the inhibition and therapeutic effect of hyperesthesia symptom and with early stage hyperesthesia inhibitory effect is also good, it contains potassium nitrate, (A) α-sodium olefin sulfonate and (B) NaLS, and A is 0.3~3 relative to the mass ratio (A/B) of B.
Description
Technical field
The present invention relates to Dentrifice compositions.
Background technique
Hyperesthesia (dentine acroesthesia) refers to that enamel or cementum disappear and expose dentine, exposing
Dentine due to by temperature, chemically or mechanical external irritant and the transient very offending pain that generates
Bitterly.It is now recognized that the reason of pain is that external irritant is conducted to caused by nerve via dentinal tubule.
As being related to inhibiting hypersensitive technology by dental health products such as dentifrices, it is known that have closing tooth sheet
The method of the method and paralysis nerve of matter tubule.
As closing dentinal tubule method, it is known that the method for example having using aluctyl.Aluctyl has blocking
The effect of Dentinal tubules, while also there is the astriction (patent document 1,2) to gum.
As paralysis nerve method, it is known that the method (patent document 3,4) having using sylvite such as potassium nitrate.
Existing technical literature
Patent document
Patent document 1: Japanese Patent Laid-Open 7-291844 bulletin
Patent document 2: Japanese Patent Laid-Open 2003-26556 bulletin
Patent document 3: Japanese Patent Laid-Open 2003-73246 bulletin
Patent document 4: Japanese patent special table 2004-506663 bulletin
Summary of the invention
Problems to be solved by the invention
But status is, even if using the above method, it usually needs one month or more time reduced, eliminates pain, hair
Simultaneous is painful therebetween by patient.Especially in the state of with hyperesthesia symptom, pain can be felt when due to brushing teeth,
Therefore difficulty of usually brushing teeth, it cannot sufficiently remove and adhere on dental surface and the spot of deposition, plaque, swill, tobacco tar
Equal dental surfaces dirt, so that there is bring adverse effect to holding oral hygiene.It can therefore, it is intended that developing one kind
To inhibit hyperesthesia symptom in early stage, excellent and use feeling is also good in the inhibition and therapeutic effect of hyperesthesia symptom
Dentrifice composition.
In view of the foregoing, project is to provide a kind of Dentrifice composition the present invention, by having early stage to feel
Allergy inhibitory effect and excellent and use feeling is also good in the inhibition and therapeutic effect of hyperesthesia symptom.
The means to solve the problem
The present invention provides (1) below~(3).
(1) a kind of Dentrifice composition contains potassium nitrate, (A) α-sodium olefin sulfonate and (B) NaLS, A phase
Mass ratio (A/B) for B is 0.3~3.
(2) Dentrifice composition according to (1), further contains polyethylene glycol.
(3) Dentrifice composition according to (1) or (2), is dentifrice composition.
Invention effect
According to the present invention it is possible to which providing a kind of can generate neural paralysis effect and promptly generate while start to brush teeth
The Dentrifice composition of hyperesthesia inhibitory effect.In addition, the present invention is poly- by further including in the Dentrifice composition
Ethylene glycol, the salubrious sense after can also providing the inhibition for being not only advantageous for acroesthesia or mitigation and brushing teeth also good clean the teeth
Agent composition.
Specific embodiment
Hereinafter, the present invention will be described in detail.
" hyperesthesia inhibitory effect " in this specification refers to the effect for inhibiting the breaking-out of hyperesthesia symptom.
In addition, " the early stage hyperesthesia inhibitory effect " in this specification refers at least from starting (brushing) 1 that brush teeth
After minute, preferably from starting after brushing teeth 30 seconds, more preferably from starting after brushing teeth 10 seconds, after most preferably brushing teeth since just, just produce
The raw effect for inhibiting the breaking-out of hyperesthesia symptom.
One mode of Dentrifice composition of the invention contains potassium nitrate, (A) α-sodium olefin sulfonate and (B) lauryl sulphur
Sour sodium, A are 0.3~3 relative to the mass ratio (A/B) of B.
A in Dentrifice composition of the invention is usually 0.3~3 relative to the mass ratio (A/B) of B, but preferably 0.3~
2, more preferable 0.5~1.If A/B is less than above range, hyperesthesia inhibitory effect is generated slow sometimes, in addition, A/B is greater than upper
If stating range, greasy feeling strengthens etc. are sometimes to use feeling variation.
The combined amount of potassium nitrate in Dentrifice composition of the invention is not particularly limited, but relative to of the invention clean
Tooth agent total composition, preferably 0.1~7 mass %, more preferable 0.5~5 mass %.If the combined amount of potassium nitrate is very few, have
The abundant sensigenous allergy inhibitory effect of Shi Buneng, in addition, if the combined amount of potassium nitrate is excessive, metallic taste enhancing sometimes to
Use feeling is deteriorated.
The combined amount of (A) α-sodium olefin sulfonate in Dentrifice composition of the invention is not particularly limited, but relative to
Dentrifice composition total amount of the invention, preferably 0.5~2 mass %, more preferable 0.75~1.5 mass %.α-sodium olefin sulfonate
Combined amount it is very few if, hyperesthesia inhibitory effect generates slow sometimes, in addition, α-sodium olefin sulfonate combined amount is excessive
Words, greasy feeling strengthens etc. are sometimes to use feeling variation.
α-sodium olefin sulfonate that α-sodium olefin sulfonate optimizing alkyl chain carbochain carbon atom number in the present invention is 10~16.
The combined amount of NaLS in Dentrifice composition of the invention is not particularly limited, but relative to this hair
Bright Dentrifice composition total amount, preferably 0.5~3 mass %, more preferable 0.75~2.5 mass %.NaLS mixes
If resultant is very few, hyperesthesia inhibitory effect is generated slow sometimes, in addition, having if the combined amount of NaLS is excessive
When generate mucous membrane removing etc. to use feeling be deteriorated.
The more preferable mode of Dentrifice composition of the invention also contains polyethylene glycol other than above-mentioned three kinds of ingredients.
By containing polyethylene glycol in Dentrifice composition, the salubrious sense of Dentrifice composition can be improved.
The molecular weight of polyethylene glycol in Dentrifice composition of the invention is not particularly limited, but preferably 1000~
10000, more preferable 3000~5000.If the molecular weight of polyethylene glycol is less than or greater than above range, cannot sufficiently it mention sometimes
High salubrious sense.
The combined amount of polyethylene glycol in Dentrifice composition of the invention is not particularly limited, but relative to of the invention
Dentrifice composition total amount, preferably 0.1~3 mass %, more preferable 0.3~1 mass %.The combined amount of polyethylene glycol is more than or lacks
If above range, salubrious sense can't improve enough sometimes.
Since Dentrifice composition of the invention has early stage hyperesthesia inhibitory effect, it is preferred for hyperesthesia
Patient, but can also prophylactically be used to prevent hyperesthesia from breaking out.
The form and dosage form of Dentrifice composition of the invention are not particularly limited.Such as it can be formulated as liquid system
The various forms such as (liquid, liquid, paste), solid system (solid, solid fraction).As the example of dosage form, for example there are toothpaste, liquid are clean
The Dentrifice compositions such as tooth agent, liquid dentifrice, toothpaste powder.Wherein, the preferred dentifrice composition of Dentrifice composition of the invention.
In the range of not interfering effect of the present invention, in addition to above-mentioned each ingredient, may be used also in Dentrifice composition of the invention
Known any ingredient in manufacture to properly mix Dentrifice composition.As any ingredient, such as example there are grinding agents, viscous
It is mixture, adhesion agent (wetting agent), surfactant, sweetener, preservative, fragrance, medicinal ingredient, colorant, pH adjusting agent, molten
Agent, excipient can suitably be selected according to dosage form.The concrete example of any ingredient is given below, but may be combined in the present invention
Dentrifice composition in any ingredient be not limited thereto.
As grinding agent, such as example there are silicic acid anhydride, crystalline silica, non-crystalline silica, silica gel, alumina silicate etc.
Silica-based grinding agent, zeolite, calcium monohydrogen phosphate anhydride, dicalcium phosphate dihydrate, calcium pyrophosphate, calcium carbonate, hydroxide
Aluminium, aluminium oxide, magnesium carbonate, tricresyl phosphate magnesium, zirconium silicate, tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, synthetic resin grinding agent
Deng.Wherein, from the viewpoint of blistering, preferably silica-based grinding agent.Grinding agent can be used alone or combine
Using two or more.Combined amount when being mixed into grinding agent is preferably 2~40 mass % of Dentrifice composition total amount, more preferably
5~20 mass %.
As adhesive, such as example there are pulullan polysaccharide, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl are fine
Tie up element, sodium carboxymethylcellulose, carragheen, sodium alginate, xanthan gum, Sodium Polyacrylate, Arabic gum, guar gum, locust bean
Glue, polyvinyl alcohol, polyvinylpyrrolidone, carboxyl vinyl polymer etc..Adhesive can be used alone or combine
Using two or more.Combined amount when using adhesive is 0.01~3 mass % usually relative to Dentrifice composition total amount.
As adhesion agent (wetting agent), such as example there are D-sorbite, propylene glycol, butanediol, glycerol etc..Adhesion agent can be with
It is used singly or in combination of two or more kinds.Combined amount when using adhesion agent can not interfere effect of the present invention
It is determined in range, is 1~60 mass % usually relative to Dentrifice composition total amount.
As surfactant, such as example there are anionic surfactant, nonionic surfactants etc..
As anionic surfactant, such as example there are N- acyl amino hydrochlorates, N- acyl group sulfonate, alkylsurfuric acid
Salt, sulfate of fatty acid glyceride etc..Wherein, from versatility aspect, preferably N- acyl amino hydrochlorate, alpha-olefin sulfonic acid
Salt, alkyl sulfate etc., from foaminess and stability in hard water aspect, more preferable sodium lauroyl sarcosine, NaLS
Deng.
As nonionic surfactant, such as example there are polyoxyethylene alkyl ether, PULLRONIC F68 block are total
Polymers, Crodaret, the polyoxyethylene ether of glyceride, sucrose fatty ester, alkanolamide, fatty acid glyceride
Deng.Wherein, from versatility aspect, be suitable for using polyoxyethylene alkyl ether, Crodaret, alkanolamide,
Span etc..The carbon chain length of polyoxyethylene alkyl ether alkyl chain is preferably 14~18 in terms of carbon atom number.Polyoxy second
The ethylene oxide of the allylic alkylation ether addition molal quantity that is averaged is preferably 15~30.The ethylene oxide of Crodaret is average
Addition molal quantity (average addition EO) is preferably 20~100.The carbon chain length carbon atom number of alkanolamide alkyl chain is preferably 12~
14.The fatty acid carbon atoms number of Span is preferably 12~18.The fatty acid of Polyoxyethylene Sorbitol Fatty Acid Esters
Carbon atom number is preferably 16~18.In addition, the ethylene oxide of Polyoxyethylene Sorbitol Fatty Acid Esters is averaged, addition molal quantity is preferred
It is 10~40.
When using surfactant, it can be used alone or be applied in combination and is two or more.Use surfactant
When combined amount usually relative to Dentrifice composition total amount be 0~10 mass %, preferably 0.01~5 mass %.
As sweetener, for example, for example there are saccharin sodium, stevioside, neohesperidin dihydrochalcone, glycyrrhizic acid, peryllartine,
To methoxycinnamic aldehyde, Talin, palatinose, maltitol, xylitol, arabite etc..It, can be with when using sweetener
It is used singly or in combination of two or more kinds.When using sweetener, combined amount can not damage effect of the present invention
In the range of be suitably determined.
As preservative, such as sodium benzoate, methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, right can be mixed
The p-hydroxybenzoates such as butoben, ethylenediaminetetraacetic acid salt, benzalkonium chloride etc..When using preservative, Ke Yidan
Solely it is used alone or in combination of two or more.These ingredients within the scope of the effect of the invention can be usually to use
Amount mixing.
As fragrance, such as example there are natural perfume material, synthetic perfumes (single fragrance), the fragrance (grease fragrance (oiliness that reconciles
Fragrance), powder perfume etc.), one or more of these can be used.
As natural perfume material, such as example there are frankincense oil, parsley oil, oleum anisi, eucalyptus oil, wintergreen, cinnamon oil, peppermints
Alcohol oil, oleum menthae viridis, peppermint oil, lemon oil, coriander oil, orange-seed oil, mandarin oil, lime oil, lavender oil, oreodaphene, spring are yellow
Elecampane oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, neroli oil, attar of roses, jasmine oil, flag flower leaching
Cream, Peppermint essential oil, rose essential oil, citrus flower, tangerine oil, mixed fruit oil, arbusterol, Ceylon cinnamon oil, caryophyllus oil, grape
Oil, thyme linaloe oil, sage oil, peppermint oil, rosemary oil, marjoram oil, origanum oil, oil of grapefruit, tangerine oil (sweetie
Oil), shaddock oil etc..
As single fragrance, such as example there are carvol, anethole, gaultherolin, cinnamic acid, linalool, linalools
Acetic acid esters, limonene, menthones, menthyl acetate, sobrerone, octanal, citral, pulegone, carvacryl acetate, anisaldehyde,
Ethyl acetate, ethyl butyrate, hexamethylene propylene carbonate, methyl anthranilate, ortho-aminobenzoic acid ethyl methyl esters, chinese cymbidium
Ketone, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, furfural,
Trimethylpyrazine, ethyl lactate, ethyl thioacetate, cineole, eugenol etc..
It is fragrance made of single fragrance and/or natural perfume material reconciliation as reconciliation fragrance, such as example there are takasago perfume
Material, strawberry perfume, apple perfume, banana incense, pineapple perfume, grape perfume, mango perfume, tropical fruit (tree) perfume, butter perfume, milk, Yoghourt perfume, water
Fruit mixes perfume, brisbane pennyroyal perfume (or spice) etc..
To the form of fragrance, there is no limit can be essential oil, extract, solids or by any spraying dry of these
Any one of powder made of dry.
It is preferred that using the above-mentioned fragrance of 0.1~2 mass % in preparation composition.
As medicinal ingredient, such as example there are following component: the fluorine such as sodium monofluorophosphate, sodium fluoride, stannous fluoride, strontium fluoride
Compound；Sterilizations or the antibacterial agents such as Chlorhexidine, triclosan, isopropyl methyl phenol, Cetylpyridinium Chloride, zinc gluconate, zinc citrate；
The tartar preventing agents such as condensed phosphate, ethanehydroxy diphosphonate；Tranexamic acid, dipotassium glycyrrhizinate salt, ε-aminocaproic acid, Cortex Phellodendri mention
Take the antiphlogistics such as object；The coating agents such as hydroxyethyl cellulose dimethyl diallyl ammonium chloride；Allantoin aluminium chloride, vitamin
C, the astringents such as chlorinated lysozyme, enoxolone and its esters, sodium chloride, allantoin；Hyperesthesia inhibitor such as strontium chloride etc..
It is suitably set in the range that combined amount when using medicinal ingredient can be pharmaceutically subjected to for each medicinal ingredient respectively.
As colorant, safflower red pigment, Gardenia Yellow, gardenia blue pigment, Perilla color, red yeast rice can be used for example
The natural colours such as pigment, deodorized red cabbage color, carrot pigment, rose of Sharon pigment, cacao color, spirulina blue color, tamarind pigment
Element；The methods such as No. 3 red, No. 104 red, No. 105 red, No. 106 red, yellow 4, Sunset Yellow FCF, green 3, blue 1
Determine dyestuff；Riboflavin, chlorophyll copper sodium, titanium dioxide etc..When being mixed into colorant, combined amount is relative to Dentrifice composition
Total amount is preferably 0.00001~3 mass %.
In view of use feelings such as mucous membrane of mouth stimulations or to the influence of tooth decalcification, the pH of Dentrifice composition of the invention
Usually 6~10, the general context of more preferable pH7~9.As pH adjusting agent, such as example there are acetic acid, hydrochloric acid, sulfuric acid, nitre
Acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide, sodium acetate, carbon
The acid such as sour sodium, sodium citrate, natrium hydrocitricum, sodium phosphate, sodium dihydrogen phosphate or alkali, buffer.It is mixed when using pH adjusting agent
Resultant can be suitably determined within the scope of the effect of the invention.
As solvent, such as example there are the carbon atom numbers such as water and ethyl alcohol, propyl alcohol in 3 lower alcohols below.Solvent is usually matched
Enter in the Dentrifice composition of liquid system.When being mixed into solvent, combined amount when solvent is water is total relative to Dentrifice composition
Amount is preferably 20~95 mass %.Combined amount when solvent is lower alcohol relative to Dentrifice composition total amount is preferably 1~20
Quality %.
As excipient, such as example there are syrup, glucose, fructose, inverted sugar, dextrin, oligosaccharide etc..It is mixed into figuration
Combined amount when agent can be suitably determined within the scope of the effect of the invention.
Embodiment
In the following, specifically describing the present invention by embodiment, but the present invention is not limited by following embodiments.In following examples
% indicate quality percentage %.
The details of the primary raw material used is as follows:
Potassium nitrate: Wako Pure Chemicals Co., Ltd. system；
α-sodium olefin sulfonate: Lion Corporation's system；
NaLS: Toho Chemical Industry Co., Ltd.'s system；
Polyethylene glycol (molecular weight 4000): Sanyo Chemical Industries, Ltd.'s system；
Polyethylene glycol (molecular weight 1000): Sigma-Aldrich corporation；
Polyethylene glycol (molecular weight 10000): Sigma-Aldrich corporation.
(embodiment 1~11 and the Comparative Examples 1 to 5 (preparation of dentifrice composition))
(manufacturing method of the dentifrice composition of Examples 1 to 8 and the Comparative Examples 1 to 5)
1. mixed dissolution water soluble ingredient (in addition to adhesive, propylene glycol) prepares A phase in distilled water under room temperature.
2. dispersing preparation B phase in propylene glycol for adhesive under room temperature.
3. addition mixing B phase, prepares C phase in the A phase in stirring.
4. removing the water solubilitys such as fragrance, grinding agent using 1.5L kneader (tor works made) mixing in C phase under room temperature
Ingredient except ingredient depressurizes (2666Pa) deaeration, obtains Dentrifice composition 1.2kg.
5. the Dentrifice composition of production is filled into 50g pipe, for testing.
(manufacturing method of the dentifrice composition of embodiment 9~11 (being mixed into polyethylene glycol))
1. under room temperature in distilled water mixed dissolution contain polyethylene glycol water soluble ingredient (except adhesive, propylene glycol it
A phase is prepared outside).
2. dispersing preparation B phase in propylene glycol for adhesive under room temperature.
3. addition mixing B phase, prepares C phase in the A phase in stirring.
4. removing the water solubilitys such as fragrance, grinding agent using 1.5L kneader (tor works made) mixing in C phase under room temperature
Ingredient except ingredient depressurizes (2666Pa) deaeration, obtains Dentrifice composition 1.2kg.
5. the Dentrifice composition of production is filled into 50g pipe, for testing.
In the dentifrice composition obtained as described above, according to following tests example, dentifrice composition to Examples 1 to 8 and
Dentifrice composition progress early stage hyperesthesia inhibitory effect, metallic taste or the greasy feeling of comparative example 1~6 and commenting for mucous membrane removing
Valence carries out early stage hyperesthesia inhibitory effect, metallic taste or greasy feeling to the dentifrice composition of embodiment 9~11, mucous membrane is removed
And the evaluation clearly felt.As a result as shown in table 1~3.
(test example)
With the entitled participant of hyperesthesia patient 10.
The dentifrice composition of preparation is squeezed out from tubular container, about 1cm is squeezed out on toothbrush, is based on standards of grading below
And evaluation criterion, to early stage hyperesthesia inhibitory effect when usually equally brushing teeth 3 minutes, metallic taste or greasy feeling, mucous membrane
Removing and salubrious sense are evaluated.
(1) hyperesthesia inhibitory effect
Evaluate the pain in the hyperesthesia illness area in brushing teeth.
The standards of grading of pain are recorded in (i), evaluation criterion is recorded in (ii).
(i) standards of grading
After 5 brush teeth since just, imperceptible pain
4 from starting after brushing teeth 10 seconds, imperceptible pain
3 from starting after brushing teeth 30 seconds, imperceptible pain
2 from starting after brushing teeth 1 minute, imperceptible pain
1 feels pain
(ii) evaluation criterion
The average mark of 10 people of ◎ is at 4.0 points or more
The average mark of 0 10 people divides at 3.0 points or more and less than 4.0
The average mark of 10 people of △ divides at 2.0 points or more and less than 3.0
The average mark of × 10 people divides less than 2.0
(2) metallic taste or greasy feeling
Metallic taste or greasy feeling during evaluation is brushed teeth and after brushing teeth.
Metallic taste or the standards of grading of greasy feeling are recorded in (i), evaluation criterion is recorded in (ii).
(i) metallic taste or the standards of grading of greasy feeling
5 totally can not feel
4 slightly feel
3 feel
2 feel strongly
1 very strongly feels
(ii) metallic taste or the evaluation criterion of greasy feeling
The average mark of 10 people of ◎ is at 4.0 points or more
The average mark of 0 10 people divides at 3.0 points or more and less than 4.0
The average mark of 10 people of △ divides at 2.0 points or more and less than 3.0
The average mark of × 10 people divides less than 2.0
(3) mucous membrane is removed
Mucous membrane after evaluation is brushed teeth is removed.
The standards of grading of mucous membrane removing are recorded in (i), evaluation criterion is recorded in (ii).
(i) standards of grading of mucous membrane removing
Standards of grading
5 absolutely not occur
4 slightly occur
3 occur
2 consumingly occur
1 very strongly occurs
(ii) evaluation criterion of mucous membrane removing
Standards of grading
The average mark of 10 people of ◎ is at 4.0 points or more
The average mark of 0 10 people divides at 3.0 points or more and less than 4.0
The average mark of 10 people of △ divides at 2.0 points or more and less than 3.0
The average mark of × 10 people divides less than 2.0
(4) salubrious sense
Evaluate the salubrious sense after brushing teeth.
The standards of grading clearly felt are recorded in (i), evaluation criterion is recorded in (ii).
(i) standards of grading clearly felt
5 is very good
4 is good
3 are difficult to evaluate
2 is poor
1 is excessively poor
(ii) evaluation criterion clearly felt
The average mark of 10 people of ◎ is at 4.0 points or more
The average mark of 0 10 people divides at 3.0 points or more and less than 4.0
The average mark of 10 people of △ divides at 2.0 points or more and less than 3.0
The average mark of × 10 people divides less than 2.0
Table 1 (embodiment)
Table 2 (embodiment)
Table 3 (comparative example)
Comparative example 6 is due to being free of surfactant, excessively poor, its use feeling in addition to metallic taste and greasy feeling of blistering
Difference.Specifically, preparation does not reach each intraoral corner, not only outwash sense is poor, but also plaque removing is insufficient, cuts
The weak basic function of toothpaste.
Claims (3)
1. a kind of Dentrifice composition contains potassium nitrate, (A) α-sodium olefin sulfonate and (B) NaLS；A is relative to B
Mass ratio A/B be 0.5~3；Relative to Dentrifice composition total amount, the content of (A) α-sodium olefin sulfonate is 0.5~2 matter
% is measured, the content of (B) NaLS is 0.5~3 mass %.
2. Dentrifice composition according to claim 1, further contains polyethylene glycol.
3. Dentrifice composition according to claim 1 or 2 is dentifrice composition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-222580 | 2013-10-25 | ||
| JP2013222580A JP6092751B2 (en) | 2013-10-25 | 2013-10-25 | Dentifrice composition |
| PCT/JP2014/078355 WO2015060426A1 (en) | 2013-10-25 | 2014-10-24 | Tooth paste composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105658194A CN105658194A (en) | 2016-06-08 |
| CN105658194B true CN105658194B (en) | 2019-03-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480058002.4A Active CN105658194B (en) | 2013-10-25 | 2014-10-24 | Dentrifice composition |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP6092751B2 (en) |
| KR (1) | KR101980563B1 (en) |
| CN (1) | CN105658194B (en) |
| MY (1) | MY179021A (en) |
| WO (1) | WO2015060426A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017094579A1 (en) * | 2015-11-30 | 2017-06-08 | ライオン株式会社 | Dentifrice composition and oral biofilm removing agent |
| WO2017094583A1 (en) * | 2015-11-30 | 2017-06-08 | ライオン株式会社 | Oral composition |
| JP2017141178A (en) * | 2016-02-09 | 2017-08-17 | ライオン株式会社 | Dentifrice composition |
| US11071704B2 (en) * | 2017-12-27 | 2021-07-27 | Kao Corporation | Oral composition |
| JP7159850B2 (en) * | 2018-12-21 | 2022-10-25 | ライオン株式会社 | oral composition |
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|---|---|---|---|---|
| JPH08175943A (en) * | 1994-12-22 | 1996-07-09 | Lion Corp | Composition for oral cavity |
| JP2005289917A (en) * | 2004-04-01 | 2005-10-20 | Lion Corp | Dentifrice composition |
| CN101938975A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Dual component oral care product |
| JP2013151474A (en) * | 2011-12-26 | 2013-08-08 | Lion Corp | Composition for oral cavity and oral cavity biofilm removing agent |
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| JPH07291844A (en) | 1994-04-28 | 1995-11-07 | Sunstar Inc | Composition for oral cavity |
| EP1331919A4 (en) | 2000-08-21 | 2005-11-16 | Block Drug Co | Dental composition for hypersensitive teeth |
| JP2003026556A (en) | 2001-07-11 | 2003-01-29 | Lion Corp | Tooth paste composition |
| JP2003073246A (en) | 2001-08-31 | 2003-03-12 | Sunstar Inc | Composition for oral cavity |
| JP5709639B2 (en) * | 2011-05-02 | 2015-04-30 | ライオン株式会社 | Oral composition |
-
2013
- 2013-10-25 JP JP2013222580A patent/JP6092751B2/en active Active
-
2014
- 2014-10-24 CN CN201480058002.4A patent/CN105658194B/en active Active
- 2014-10-24 WO PCT/JP2014/078355 patent/WO2015060426A1/en active Application Filing
- 2014-10-24 KR KR1020167000895A patent/KR101980563B1/en active IP Right Grant
- 2014-10-24 MY MYPI2016700944A patent/MY179021A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08175943A (en) * | 1994-12-22 | 1996-07-09 | Lion Corp | Composition for oral cavity |
| JP2005289917A (en) * | 2004-04-01 | 2005-10-20 | Lion Corp | Dentifrice composition |
| CN101938975A (en) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | Dual component oral care product |
| JP2013151474A (en) * | 2011-12-26 | 2013-08-08 | Lion Corp | Composition for oral cavity and oral cavity biofilm removing agent |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101980563B1 (en) | 2019-05-21 |
| JP2015083556A (en) | 2015-04-30 |
| WO2015060426A1 (en) | 2015-04-30 |
| MY179021A (en) | 2020-10-26 |
| KR20160068724A (en) | 2016-06-15 |
| JP6092751B2 (en) | 2017-03-08 |
| CN105658194A (en) | 2016-06-08 |
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