JPWO2009034919A1 - Oral composition and method for improving astringency of oral composition - Google Patents

Abstract

In the composition for oral cavity, (a) one or more aluminum compounds selected from potassium aluminum sulfate, dry potassium aluminum sulfate, and ammonium ammonium sulfate, and (b) sodium chloride are blended, The blending amount is 0.2 to 3% by mass. According to the composition for oral cavity of the present invention and the method for improving the astringency of the composition for oral cavity, it exhibits a high astringent effect when used in the oral cavity, and continues to have a high astringent effect after use, and is derived from a polyvalent metal. It is possible to obtain an oral composition having no metallic taste, excellent usability, and good safety.

Description

  The present invention exhibits a high astringent effect at the time of use in the oral cavity, is excellent in a sustained astringent effect after use, has no metallic taste derived from a polyvalent metal, has good usability, The present invention relates to a composition for oral cavity that is excellent in the tightening effect of the neck and is effective in preventing or improving periodontal diseases, and a method for improving the convergence of the oral composition.

  Symptoms of periodontal diseases that have increased in recent years include pain and redness in the cervical region due to bacterial infections mainly consisting of obligate anaerobic Gram-negative bacilli such as P. gingivalis. Therefore, it is said that tightening of the oral cavity, particularly the tooth neck, is useful as an effective means for preventing and improving such periodontal diseases.

  As a means for tightening the cervical part, it is an effective means to mix a polyvalent metal compound such as zinc oxide and aluminum lactate and a natural astringent such as polyphenol and tannin into an oral care product. Among these components blended in the oral care product, the polyvalent metal compound has a high astringency, so that it is blended in the oral composition and put on the market.

  However, oral compositions containing polyvalent metal compounds are difficult to withstand use in the oral cavity due to the occurrence of metal taste derived from polyvalent metals, and their astringency is temporary and inferior in sustainability. Was an issue.

  In order to solve such problems, for example, in Patent Document 1 (Japanese Patent Laid-Open No. Sho 61-186307), astringency is enhanced by blending sodium carboxymethylcellulose or sodium alginate with an oral lactose composition containing aluminum lactate. However, in this case, the metal taste during use is enhanced and it is difficult to withstand use, and it is difficult to continuously exhibit excellent astringency.

  In this way, it is effective to mix an astringent component in a composition for oral cavity as a means for preventing and improving periodontal diseases. However, the oral cavity has a high astringency continuously in the oral cavity and good usability. It has been difficult to obtain a composition for use in the prior art.

JP-A-61-186307 JP 59-157014 A JP-A-3-258724 JP-A-5-58895 JP 2001-163742 A JP 2003-212743 A

  The present invention has a high astringent effect in the oral cavity, maintains an astringent effect even after use, and has excellent usability without feeling metallic taste, and astringent properties of the oral composition An object is to provide an improvement method.

  As a result of intensive studies to achieve the above object, the present inventors have determined that (a) one or two or more kinds of aluminum compounds selected from aluminum potassium sulfate, dry aluminum potassium sulfate, and aluminum ammonium sulfate are 0.2. ~ 3% by mass and (b) sodium chloride are used in combination, preferably by combining and blending the component (b) at a mass ratio of 0.5 to 15 with respect to the component (a) in the oral cavity. It has been found that a high astringent effect is exhibited during use, a high sustained astringent effect is exhibited even after use, and an oral composition having excellent usability without a metallic taste is obtained. .

  In addition, aluminum potassium sulfate, dry aluminum potassium sulfate (anhydrous potassium aluminum sulfate), and aluminum ammonium sulfate are known as alum and have an astringent action and a bactericidal action. It is well-known as a compounding component to a composition, for example, patent documents 2-6 etc. are proposed. Patent Document 2 describes that a dentifrice containing an azulene compound is stabilized by the addition of an aluminum compound. Patent Document 3 discloses that an aluminum salt such as alum and anionic surface activity is effective in suppressing the hypersensitivity of zinc salt. Improved by blending an agent, cited reference 4 includes a metal compound, borax, and alkali metal chloride containing aluminum as a component such as aluminum potassium sulfate (alum) in pyridone or a salt thereof exhibiting an antibacterial action. It is described that the solution is stabilized by adding. In Cited Document 5, synthetic amorphous titanium-bonded silicate is used as an abrasive, and an aluminum salt can be used in combination to improve the plaque suppression effect. In Cited Document 6, a complex of a water-soluble aluminum compound and hinokitiol is included. It is described that, when formed, a high effect of preventing or treating hypersensitivity is exhibited.

  On the other hand, when the alum was simply blended into the oral composition, the present inventors had difficulty in obtaining a satisfactory astringent effect and inferior usability, and were difficult to put into practical use. a) An aluminum compound selected from potassium aluminum sulfate, dry aluminum potassium sulfate, and aluminum ammonium sulfate is blended in a specific blending amount, and (b) a combination of sodium chloride is blended, particularly the components (a) and (b) are identified. By using together at a ratio, as will be apparent from the examples described later, the two components act synergistically, exhibiting a high astringent effect during use in the oral cavity, and this astringent effect continues even after use. Furthermore, it discovered that the metal taste derived from a polyvalent metal was suppressed and the outstanding usability was obtained.

  Such an effect of the present invention is that aluminum lactate or the like is a simple aluminum salt (single salt), whereas an aluminum compound selected from aluminum potassium sulfate, dry aluminum potassium sulfate, and aluminum ammonium sulfate is a double salt. Due to the balance of solubilization with sodium chloride in the oral cavity, this double salt makes it difficult to feel the metallic taste, and the protein conversion performance in the oral cavity during and after use is increased specifically and has an excellent astringent effect. It is thought that it was able to be achieved by expressing. Even if it is an aluminum compound, the effect of this invention cannot be achieved if a single salt such as aluminum lactate is blended.

Therefore, the present invention provides the following oral composition and a method for imparting astringency to the oral composition.
[I] (a) Contains one or more aluminum compounds selected from aluminum potassium sulfate, dry potassium aluminum sulfate, and aluminum ammonium sulfate, and (b) sodium chloride, and the amount of the component (a) Is a composition for oral cavity, wherein the composition is 0.2 to 3% by mass.
[II] The composition for oral cavity according to [I], which contains the component (b) at a mass ratio of 0.5 to 15 with respect to the component (a).
[III] The composition for oral cavity according to [I] or [II], which is prepared as a dentifrice.
[IV] A method for improving the astringency of an oral composition containing one or more aluminum compounds selected from potassium aluminum sulfate, dry aluminum potassium sulfate, and aluminum ammonium sulfate, wherein the composition for oral cavity The method for improving the astringency of the composition for oral cavity, wherein 0.2 to 3% by mass of the aluminum compound is blended with sodium chloride.
[V] The method for improving convergence according to [IV], wherein the component (b) is blended at a mass ratio of 0.5 to 15 with respect to the component (a).
[VI] The method for improving astringency according to [IV] or [V], wherein the astringency of the dentifrice composition is improved.

  According to the composition for oral cavity of the present invention and the method for improving the astringency of the composition for oral cavity, it exhibits a high astringent effect when used in the oral cavity, and continues to have a high astringent effect after use, and is derived from a polyvalent metal. An oral composition having no metallic taste, excellent usability, and good safety can be obtained. It can be prepared in various dosage forms and used widely.

  The composition for oral cavity of the present invention is prepared as a toothpaste, such as a toothpaste, a liquid toothpaste, a liquid toothpaste, a moisturized toothpaste, a mouthwash, etc., particularly as a toothpaste. (A) Aluminum potassium sulfate, dried One or more selected from aluminum potassium sulfate and aluminum ammonium sulfate, and (b) sodium chloride are essentially contained.

The aluminum compound selected from the component (a) potassium aluminum sulfate, dry aluminum potassium sulfate (anhydrous potassium sulfate sulfate), and aluminum ammonium sulfate is generally known by the name of alum, and has the following general formula ( It is a hydrate or anhydride of a sulfate (double salt) of aluminum and potassium or ammonium represented by 1).
R ¹ Al (SO ₄ ) ₂ · 12H ₂ O (1)
(Wherein R ¹ is K or NH ₄ )

  (A) As a component, a commercial item can be used, for example, potassium alum (made by Daimei Chemical Co., Ltd.) as potassium aluminum sulfate, and baked alum (made by Daimei Chemical Co., Ltd.) as dry aluminum potassium sulfate. As ammonium aluminum sulfate, ammonium alum (manufactured by Daimei Chemical Co., Ltd.) and the like can be used.

  (A) The aluminum compound of component (a) may be used alone or in combination of two or more. Among them, aluminum potassium sulfate or potassium potassium sulfate sulfate is used alone, or both components are combined. It is preferable to mix.

  (A) The compounding quantity of a component is 0.2 to 3% (mass%, and the following is same) with respect to the composition whole quantity, Preferably it is 0.3 to 2%. If it is less than 0.2%, sufficient sustained astringency may not be exhibited. If it exceeds 3%, a metallic taste may occur or irritation may occur to the oral mucosa.

  (B) The sodium chloride can use a commercial item, for example, can use the product made from Nihonkaikai Co., Ltd. as a selection special grade salt. The amount of sodium chloride is preferably 0.1 to 15%, particularly preferably 0.2 to 10%, particularly 5 to 10%, based on the total amount of the composition. If the blending amount is less than 0.1%, sufficient sustained astringency may not be exhibited. If the blending amount exceeds 15%, salty taste may occur, and sufficient oral cleaning may not be possible, or irritation to the oral mucosa may occur. is there.

  The blending ratio ((b) / (a)) of the sodium chloride of the component (b) to the aluminum compound of the component (a) is 0.5 to 15, particularly 1 to 10, especially 5 to 10 in terms of mass ratio. Preferably, by blending in this range, the convergence effect at the time of use and the continuous convergence effect after use can be further improved.

  The oral composition of the present invention can be blended with other known additives as optional components in addition to the above essential components in a range not impeding the effects of the present invention, depending on the dosage form and the like. For example, in the case of toothpaste, abrasives, thickeners, binders, surfactants, and sweeteners, preservatives, active ingredients, pigments, fragrances, etc. can be blended as necessary. It can mix and can manufacture by a normal method.

  As abrasives, anhydrous silica, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate, dibasic calcium phosphate anhydride, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, Polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zeolite, zirconium silicate, tertiary calcium phosphate, hydroxyapatite, fluoroapatite, calcium deficient apatite, tertiary calcium phosphate , Tetracalcium phosphate, eighth calcium phosphate, synthetic resin-based abrasive and the like (usually 2 to 50%, particularly 10 to 40%).

  As the thickener, one kind or two or more kinds such as glycerin, sorbit, propylene glycol, polyethylene glycol having a molecular weight of 200 to 6000, ethylene glycol, reduced starch saccharified product or the like can be used (normally 5 to 5). 50%).

  As binder, organic binders such as sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol alginate, carboxymethylcellulose sodium, hydroxyethylcellulose, carbopol, guar gum, gelatin, Avicel, montmorillonite, kaolin, bentonite, etc. Examples thereof include inorganic binders (normally 0 to 5%, particularly 0.1 to 3%).

  As the surfactant, as an anionic surfactant, for example, sodium lauryl sulfate, lauroyl sarcosine sodium, polyoxyethylene alkyl sulfate, N-lauroyl taurine salt, α-olefin sulfonate, etc. Nonionic surfactants such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and the like, for example, alkyl glycosides, sucrose fatty acid esters, alkylol amides, polyoxyethylene sorbitan monostearate Rate, polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkyl ether, decaglyceryl laurate and the like (usually 0.1 to 3%, particularly 0.5 to 2%).

  Sweeteners include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, etc., and preservatives include parabens (paraoxybenzoate) such as butylparaben and ethylparaben. And sodium benzoate.

  Various active ingredients include: fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, and water-soluble phosphate compounds such as orthophosphoric acid potassium salt and sodium salt. , Tranexamic acid, epsilon-aminocaproic acid, allantoin chlorohydroxyaluminum, hinokitiol, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, glycyrrhetin, glycyrrhetic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate, etc. Chelating phosphate compounds, copper compounds such as copper gluconate, strontium chloride, potassium nitrate, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, Tokishiechiren, epi-dihydro cholesterol, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, Japanese angelica root soft extract, Phellodendron bark extract, camomile, clove, rosemary, scutellaria root, like extracts of safflower like. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, and fragrances that have been processed (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and Menthol, Carvone, Anethole, Cineol, Methyl salicylate , Synamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde , Citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl Alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacete For peroral compositions such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The well-known perfume material used can be used.

  The blending amount of the fragrance is not particularly limited, however, the above fragrance material is preferably used in a composition of 0.000001 to 1%. Moreover, it is preferable to use 0.1-2.0% of the fragrance | flavor for perfume using the said fragrance | flavor raw material in a formulation composition.

  Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, and the like.

  The material in particular of the container which accommodates the composition for oral cavity of this invention is not restrict | limited, Usually, the container used for the composition for oral cavity can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an experimental example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

[Experimental example]
A dentifrice composition (toothpaste) having the composition shown in Table 1 was prepared and evaluated as follows. The results are shown in Table 1.

(1) Preparation of test dentifrice composition A dentifrice composition having the composition shown in Table 1 was prepared by the following method, and the innermost layer was a linear low-density polyethylene 26 mm in diameter and 8 mm in diameter laminated tube (low-density polyethylene). 72 μm / ethylene / acrylic acid copolymer resin 90 μm / aluminum 10 μm / ethylene / acrylic acid copolymer resin 35 μm / linear low density polyethylene 50 μm, thickness 257 μm (manufactured by Dai Nippon Printing Co., Ltd.) was filled with 50 g. .

  For preparation of the dentifrice composition, potassium aluminum sulfate (Kari Alum, Daimei Chemical Co., Ltd.), dry aluminum potassium sulfate (baked alum, Daimei Chemical Co., Ltd.), ammonium ammonium sulfate (ammonium alum, Daimei Chemical Co., Ltd.) Co., Ltd.), sodium chloride (selected special grade salt, Nippon Seawater Co., Ltd.) was used. For other components, aluminum lactate, citric acid monohydrate, sodium hydroxide, sodium hydrogen phosphate, sodium lauryl sulfate, silicic anhydride, titanium oxide, polyethylene glycol 4000, sodium carboxymethyl cellulose, polyoxyethylene (20) curing Castor oil, saccharin sodium, sorbite solution, propylene glycol, and purified water were used as standard products for cosmetic raw material standards, and sodium monofluorophosphate was used as a standard product for quasi-drug raw material standards.

(I) Convergence in use About 10 g of a sample (test dentifrice composition) is placed on a commercially available toothbrush using 10 subjects and brushed for 3 minutes. Responses were obtained in four stages: “feel”, “slightly feel”, and “not feel at all”. Among these answers, 4 points were “very feel”, 3 points were “feel”, 2 points were “feel slightly”, and 1 point was “not feel at all”. Evaluation was made according to the following criteria from the average score of 10 people.
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(Ii) Convergence at 5 minutes after use About 1 g of the sample (test dentifrice composition) was placed on a commercial toothbrush for 10 minutes using 10 subjects, and then converged after 5 minutes after use. The answers were obtained in four levels: “I feel very”, “I feel”, “Slightly feel”, and “I don't feel at all”. Among these answers, 4 points were “very feel”, 3 points were “feel”, 2 points were “feel slightly”, and 1 point was “not feel at all”. Evaluation was made according to the following criteria from the average score of 10 people.
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(Iii) Duration of convergence effect Using 10 subjects, about 1 g of sample (test dentifrice composition) is placed on a commercial toothbrush and brushed for 3 minutes, and the time to feel the convergence effect after use is measured. Showed time.

(Iv) Metallic taste in use About 10 g of a sample (test dentifrice composition) was placed on a commercially available toothbrush using 10 subjects and brushed for 3 minutes. Responses were obtained in four stages: “feel”, “slightly feel”, and “not feel at all”. Among the answers, 4 points were “I don't feel at all”, 3 points were “Somewhat feel”, 2 points were “I feel”, and 1 point was “I feel very”. Evaluation was made according to the following criteria from the average score of 10 people.
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

  From the results of Table 1, when either (a) or (b) component is a non-mixed composition, or a composition in which the blended amount of these components is outside the scope of the present invention, the astringent feeling during use or its sustainability is poor. The metal taste during use is strong, and the feeling of use is inferior. On the other hand, the composition for oral cavity of the present invention using the components (a) and (b) in combination exhibits a high convergence effect during use, is excellent in sustainability of the effect, and is derived from a polyvalent metal. It was confirmed that the metal taste was not felt and the usability was excellent.

  Next, when oral compositions having the following compositions were prepared and evaluated in the same manner, each of them exhibited a high astringent effect during use, a high sustained astringent effect after use, and a metallic taste. It was confirmed that it was excellent in usability.

Claims (6)

  (A) 1 type, or 2 or more types of aluminum compounds chosen from aluminum potassium sulfate, dry aluminum potassium sulfate, and aluminum ammonium sulfate, and (b) sodium chloride, The compounding quantity of the said (a) component is 0. It is 2-3 mass%, The composition for oral cavity characterized by the above-mentioned.   The composition for oral cavity of Claim 1 which contains (b) component in the ratio of 0.5-15 by mass ratio with respect to (a) component.   The composition for oral cavity of Claim 1 or 2 prepared as a dentifrice.   A method for improving the astringency of an oral composition containing one or more aluminum compounds selected from aluminum potassium sulfate, dry potassium aluminum sulfate, and aluminum ammonium sulfate, wherein the aluminum composition is added to the oral composition. The method for improving the astringency of the composition for oral cavity, comprising compounding 0.2 to 3% by mass of a compound and using sodium chloride in combination.   The astringency improvement method of Claim 4 which mix | blends (b) component in the ratio of 0.5-15 with mass ratio with respect to (a) component.   The method for improving astringency according to claim 4 or 5, wherein the astringency of the dentifrice composition is improved.