JP5054306B2 - Film-like composition - Google Patents

Description

The present invention relates to a gel sheet used in cosmetics, pharmaceuticals, and the like, and a film-like composition that becomes a gel sheet by absorbing and swelling a liquid.

Conventionally, gel sheets made of water-soluble polysaccharides have been used in the fields of cosmetics and quasi drugs. For example, it is used as a pack material in the cosmetics field or a patch in the quasi-drug field. Examples of such a gel sheet include a combination of polysaccharides such as carrageenan and locust bean gum, xanthan gum and locust bean gum (Patent Document 1). In addition, there are cosmetics mainly composed of native gellan gum (Patent Document 2). Furthermore, there is a soft capsule base sheet (Patent Document 3) containing native gellan gum in starch.

  In the field of food and quasi-drugs, film-like compositions comprising water-soluble polysaccharides are used. For example, it is used as an oral refreshing agent or a film-like troche. Examples of such a film-like composition include those composed of starch and pullulan, and those mainly composed of polysaccharides such as carrageenan and polyhydric alcohol.

Japanese Patent Application No. 1-218326 JP-A-12-355518 JP 2005-170929 A

However, gel sheets made of a combination of carrageenan and locust bean gum, xanthan gum and locust bean gum have a problem that they are weak in strength and tear or break during handling. Moreover, the cosmetics using the native gellan gum described in Patent Document 2 are not sheet-like cosmetics, but are intended for use in a paste state. Furthermore, the soft capsule base sheet containing starch and native gellan gum described in Patent Document 3 has a starch content of 30% by mass and a high solid content, so the sheet is soft, so the pack material and the paste There is a problem that it is difficult to handle as an agent sheet.

Moreover, the film-form composition which consists of starch or a pullulan will melt | dissolve when immersed in liquids, such as water, and will not absorb a liquid and will become a gel sheet . A film-like composition containing carrageenan as a main component does not dissolve even when immersed in a liquid, but has a problem that the strength is remarkably reduced when the liquid is absorbed.

Accordingly, a first object of the present invention is to provide a gel sheet having high strength and high viscoelasticity. A second object of the present invention is to provide a film-like composition that swells and becomes a gel sheet without causing deterioration in strength even when immersed in a liquid.

In order to achieve the first object described above, the present inventors have conducted extensive studies, and as a result, native gellan gum, agar, carrageenan, farseleran, alginic acid, alginates, locust bean gum, tara gum, cassia gum, tamarind gum A hydrocolloid comprising at least one of pectin, deacylated gellan gum, curdlan, xanthan gum, glucomannan, gelatin, karaya gum and silium seed gum, and the mass ratio of the native gellan gum to the hydrocolloid is 99: It was found that a gel sheet having high strength and high viscoelasticity can be obtained by setting 1 to 40:60. That is, the present invention relates to a gel sheet comprising a native gellan gum, and the hydrocolloid, the mass ratio of the the native gellan gum hydrocolloid, 99: is a gel sheet, which is a 1 to 40:60 .

Further, in order to achieve the second object, the present inventors have conducted extensive studies, and as a result, native gellan gum, agar, carrageenan, farseleran, alginic acid, alginates, locust bean gum, tara gum, cassia gum, tamarind gum And a hydrocolloid comprising at least one of pectin, deacylated gellan gum, curdlan, xanthan gum, glucomannan, gelatin, karaya gum and silium seed gum, and the mass ratio of native gellan gum to hydrocolloid is 99: 1. It was found that by setting to 40:60, a film-like composition that swells and becomes a gel sheet without causing deterioration in strength even when immersed in a liquid can be obtained. That is, the present invention is a film-like composition comprising a native gellan gum and the hydrocolloid, which becomes a gel sheet by absorbing and swelling a liquid, wherein the mass ratio of the native gellan gum and the hydrocolloid is 99. 1 to 40:60.

As described above, according to the present invention, a gel sheet having high strength and high viscoelasticity can be provided. Moreover, according to this invention, even if it immerses in a liquid, it can swell without causing intensity deterioration and can provide the film-form composition used as a gel sheet .

In the gel sheet and the film-like composition according to the present invention, the mass ratio of native gellan gum to the hydrocolloid is 99: 1 to 40:60, preferably 95: 5 to 50:50, and 90:10. Or more preferably 65:35.

In the gel sheet according to the present invention, the content of the native gellan gum and the hydrocolloid is preferably 0.2 to 10.0% by mass, and 0.5 to 6.0% by weight based on the total amount of the composition. It is particularly preferred.

  The film-like composition according to the present invention is preferably adjusted so as to absorb 5 to 150 times its own weight of liquid.

In order to give flexibility, the gel sheet and the film composition according to the present invention may contain a saccharide or a polyhydric alcohol as a plasticizer. Examples of the polyhydric alcohol include glycerin, ethylene glycol, propylene glycol, sorbitol, Examples include maltitol, mannitol, xylitol, reduced starch saccharified product, glucose, fructose, galactose, xylose, saccharose, maltose, lactose and oligosaccharide.

Moreover, an additive can be added in the range which does not impair the physical property of the gel sheet which concerns on this invention, and a film-form composition greatly. Examples of the additive include inorganic or organic powders, coloring agents, and fragrances.

Examples of the method for producing a gel sheet according to the present invention include a method in which a native gellan gum and an aqueous solution of hydrocolloid are poured into a mold and cooled, or cast on a support such as a flat plate, a drum, a belt, or a film. There is a method of manufacturing by cooling, but there is no particular limitation as long as the thickness of the sheet can be made uniform.

  Examples of the method for producing the film-like composition according to the present invention include an extrusion method such as a flat die method and a calender method, and a cast solution of a native gellan gum and the hydrocolloid on a support such as a film, drum or belt. However, there is no particular limitation as long as the thickness of the film can be made uniform.

The gel sheet and film-like composition according to the present invention can be used, for example, in cosmetics, pharmaceuticals, quasi drugs, chemical products, foods, hygiene products, daily necessities, and the like.

Examples 1 and 2
Next, native gellan gum (CP Kelco) and agar (Ina Food Industry) are blended at the ratio shown in Table 1, and an aqueous solution is prepared so that the total concentration of these polysaccharides is 2% by mass. The aqueous solution was poured into a mold to a thickness of 1 mm and cooled to obtain gel sheets according to Examples 1 and 2, Reference Example 1, and Comparative Example 1.

Experimental example 1
Next, with respect to the gel sheets according to Examples 1 and 2, Reference Example 1 and Comparative Example 1, measurement of breaking stress and breaking distance and evaluation of sheet physical properties were performed. The measurement of the breaking stress and the breaking distance was performed using a rheometer (manufactured by Sun Science Co., Ltd.) and the sample temperature was 20 ° C. Measurement of the breaking stress and the breaking distance, Examples 1 and 2, Reference Example 1, and the gel sheet not itself according to Comparative Example 1, Example 1 and 2, Reference Example 1, and a diameter of 5 A stock solution of Comparative Example 1. Each gel was prepared by pouring into a cylindrical vessel of 0 cm and a height of 5.5 cm and cooling. The breaking distance means a distance until the maximum load of breaking stress is reached. The sheet was evaluated based on the flexibility and strength of the sheet. These results are shown in Table 2.

  In order for the sheet to be hard, the breaking stress should show a large value, and in order to have flexibility without breaking even when bent, the breaking distance should show a large value. Accordingly, a large both values indicate excellent sheet characteristics.

It turns out that the gel sheet which concerns on Example 1 and 2 is excellent in both a softness | flexibility and hardness compared with the gel sheet which concerns on the reference example 1 and the comparative example 1, and is a favorable sheet | seat.

Examples 4 to 8
Next, as shown in Table 3, native gellan gum (CP Kelco), agar (Ina Food Industry), carrageenan (Ina Food Industry), guar gum (Ina Food Industry), sodium alginate ( Dainippon Sumitomo Pharma Co., Ltd.) or pectin (CP Kelco Co., Ltd.) is blended at a ratio of 1: 1, and an aqueous solution is prepared so that the total concentration of these polysaccharides is 2% by mass. The gel sheets according to Examples 4 to 8 were obtained by pouring into a mold to be 1 mm and cooling. Similarly, a gel sheet made of native gellan gum was prepared as Comparative Example 2.

Experimental example 2
Next, regarding the gel sheets according to Examples 4 to 8 and Comparative Example 2, the measurement of the breaking stress and the breaking distance and the evaluation of the sheet physical properties were performed. The measurement of the breaking stress and the breaking distance was performed using a rheometer (manufactured by Sun Science Co., Ltd.) and the sample temperature was 20 ° C. The measurement of the breaking stress and the breaking distance is not the gel sheets themselves according to Examples 4 to 8 and Comparative Example 2, but the stock solutions of Examples 4 to 8 and Comparative Example 2 having a diameter of 5.0 cm and a height of 5.5 cm. Each gel was prepared by pouring into a cylindrical vessel and cooling. The sheet was evaluated based on the flexibility and strength of the sheet. These results are shown in Table 4.

As shown in Table 4, Comparative Example 2 using native gellan gum alone has a long breaking distance and flexibility, but the breaking stress is not sufficient. Therefore, when a sheet is produced, the shape retaining property of the sheet cannot be maintained. The gel sheets according to Examples 4 to 8 have strength as well as flexibility by containing a hydrocolloid as compared with Comparative Example 2.

Examples 9 to 12
Next, native gellan gum (CP Kelco), agar (Ina Food Industry), carrageenan (Ina Food Industry), or deacylated gellan gum (CP Kelco) with the formulation shown in Table 5 Thicknesses according to Examples 9 to 12 are blended so that the total concentration of these polysaccharides is 5% by mass, and glycerin is added thereto to prepare an aqueous solution. The aqueous solution is cast on a metal plate and dried. A film-like composition having a thickness of 50 μm was obtained. Similarly, film-like compositions comprising carrageenan or pullulan were produced as Comparative Examples 3 and 4.

Experimental example 3
Next, for the film-like compositions according to Examples 9 to 12 and Comparative Examples 3 and 4, the liquid absorption amount was measured and the sheet physical properties after liquid absorption were evaluated. The amount of liquid absorption is calculated by dividing the weight of a 2.5 cm × 5.0 cm film piece immersed in ion exchange water for 15 minutes by the weight of the 2.5 cm × 5.0 cm film piece before immersion. It was expressed as the swelling ratio. These results are shown in Table 6.

The film-like compositions according to Examples 9 to 12 were immersed in ion-exchanged water and then absorbed to obtain a good gel sheet . On the other hand, the film-like compositions according to Comparative Examples 3 and 4 were unable to obtain a sheet because the film was gradually dissolved after being immersed in ion-exchanged water.

Example 14
Next, as a gel sheet according to Example 14, a sheet-shaped cosmetic was prepared. When the gel sheet according to Example 14 was mixed with native gellan gum, agar, 1,3-butylene bricol and paraben in the formulation shown in Table 7 and dissolved in purified water, the temperature of the aqueous solution became 60 ° C. or lower. Vitamin C was stirred and mixed to make the whole 100%, and then this aqueous solution was poured into a mold to a thickness of 2 mm, cooled and gelled.

  The sheet cosmetic according to Example 14 had flexibility, was very easy to handle, and could be applied to the skin without entanglement of the sheet. Since the sheet strength was high, the sheet was not damaged even when handled somewhat messy.

Example 15
Next, a gel sheet according to Example 15, was prepared cooling gel sheet. The cooling gel sheet according to Example 15 was prepared by mixing native gellan gum, agar and glycerin with the formulation shown in Table 8, dissolved in purified water, and stirring and mixing L-menthol when the temperature of the aqueous solution reached 60 ° C or lower. Then, the whole was made 100%, and then this aqueous solution was poured into a mold so as to have a thickness of 2 mm and cooled to be gelled.

  The cooling gel sheet according to Example 15 lasted for 1.5 hours or longer. In addition, the cooling gel sheet according to Example 15 had high sheet strength, and even though the handling was messy, all the ones used in the test were not damaged.

Example 16
Next, a burn / wound covering sheet was produced as a gel sheet according to Example 16. The burn / wound covering sheet according to Example 16 was prepared by adding native gellan gum and agar to ion-exchanged water with the formulation shown in Table 9 and adding glycerin after heating and dissolving, and further heating and dissolving in a small amount of water. Add sodium chloride and potassium chloride, adjust the pH, fully dissolve dipotassium glycyrrhizinate, add water to adjust the amount of water, pour the solution into a mold to a thickness of 5 mm, cool and gel It was obtained by making it.

  The burn / wound covering sheet according to Example 16 did not show a tactile sensation after use, and did not adhere to the skin when peeled off. Further, the burn / wound covering sheet according to Example 16 had high sheet strength, and no damage was found in the sheet used in the test even when the handling was messy.

Example 17
Next, a soft capsule sheet was produced as a gel sheet according to Example 17. In Example 17, the soft capsule sheet was firstly mixed with a portion of the weight parts shown in Table 10 by adding a small amount of native gellan gum and hydrocolloid consisting of agar, carrageenan, xanthan gum and locust bean gum to the water in the dissolution tank while stirring. Then, the mixture was heated with stirring at 80 ° C. to 98 ° C., dissolved so as not to cause lumps, and after defoaming, the solution was cast on a drum and cooled.

  The soft capsule sheet according to Example 17 was able to be obtained by using a rotary soft capsule manufacturing apparatus. The soft capsule sheet according to Example 17 had excellent tensile strength, and the sheet was not cut during molding of the capsule, so that a good soft capsule could be obtained. Further, the soft capsule sheet according to Example 17 was excellent in strength after drying, and no liquid leakage was observed. Furthermore, the soft capsule sheet according to Example 17 was excellent in hygroscopicity, and adhesion between capsules was not observed.

Claims (2)

With native gellan gum,
From at least one of agar, carrageenan, farseleran, alginic acid, alginates, locust bean gum, tara gum, cassia gum, tamarind gum, pectin, deacylated gellan gum, curdlan, xanthan gum, glucomannan, gelatin, karaya gum and silium seed gum A hydrocolloid
A film-like composition that forms a gel sheet by absorbing liquid and swells, wherein the mass ratio of native gellan gum to the hydrocolloid is 99: 1 to 50:50 Composition. 2. The film-like composition according to claim 1 , wherein the film-like composition is adjusted so as to absorb and swell by 5 to 150 times its own weight.