CN105963723A - B ultrasonic coupling agent and preparation technology thereof - Google Patents
B ultrasonic coupling agent and preparation technology thereof Download PDFInfo
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- CN105963723A CN105963723A CN201610462373.XA CN201610462373A CN105963723A CN 105963723 A CN105963723 A CN 105963723A CN 201610462373 A CN201610462373 A CN 201610462373A CN 105963723 A CN105963723 A CN 105963723A
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- 238000005516 engineering process Methods 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000007822 coupling agent Substances 0.000 title abstract description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims abstract description 39
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 27
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229920001661 Chitosan Polymers 0.000 claims abstract description 13
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 13
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 13
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 13
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 13
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 13
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 13
- 229940046009 vitamin E Drugs 0.000 claims abstract description 13
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 13
- 239000011709 vitamin E Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 9
- 244000203593 Piper nigrum Species 0.000 claims abstract description 9
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 9
- 235000013614 black pepper Nutrition 0.000 claims abstract description 9
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 9
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 20
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 12
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 12
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- -1 reflux Substances 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 238000003384 imaging method Methods 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 9
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000012431 wafers Nutrition 0.000 description 3
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of coupling agents and discloses a B ultrasonic coupling agent which is prepared from the following raw materials: propylene glycol, glycerinum, hyaluronic acid, hydroxyethyl cellulose, lauryl sodium sulfate, vitamin E, deionized water, potassium iodide, carboxymethyl chitosan, honeysuckle and black pepper. The B ultrasonic coupling agent is reasonable in compatibility of all components, fewer in bubbles, clear in ultrasonic imaging and non-irritant to skin and has sterilization and disinfection functions.
Description
Technical field
The invention belongs to couplant technical field, be specifically related to a kind of B ultrasonic couplant and preparation technology thereof.
Background technology
The diagnostic method that BChao Shi hospital is conventional.B ultrasonic can clearly display the various sections of each internal organs and peripheral organs
Picture, owing to image is imbued with entity sense, close to the real structure dissected, ultrasonic can clarify a diagnosis in early days so applying.Ultrasonic
Diagnostic apparatus has various class, and advanced top-grade instrument structure is complicated, has high-performance, multi-functional, high-resolution and fine definition
Etc. feature.Their basic building block includes five ingredients such as transmitting, scanning, reception, signal processing and display, is divided into two big
Parts, i.e. main frame and probe.One main frame can have one, two or more probe, and can install 1 in a probe
Or dozens of is so that more than thousand wafers, such as real-time ultrasonic diagnostic probes, is formed an array element by 1 to several wafers, takes turns successively
Flow work, launch and receive acoustic energy.Wafer is made up of electrostriction material, serves as the energy conversion of electricity, sound, electricity, therefore is also referred to as
Transducer.Single-frequency, multifrequency and wideband probe is had by frequency.Ultrasonic real-time head presses the arrangement separated time battle array of piezoelectric chip, ring battle array, convex
Battle array etc., various titles in having again body surface, intracavity, pipe by purposes, some probes only several millimeters, can enter in coronary artery.
Current coupling agent for medical use and hospital's ultrasonic probe Bacteria carrying status make us may be excellent.Ultrasonic probe during hospital uses is universal
Do not disinfect, only use white cotton paper to carry out wiping after inspection, the most i.e. carry out next inspection, and medical supersonic is visited
Head frequently contacts the different crowds such as physical examination of healthy population, patients with infectious diseases, dermatosis patient, infant, anemia of pregnant woman, in clinical examination
Probe often carries multiple pathogenic microorganism, there is the potential danger of medical cross infection, causes ultrasonic probe bacterial bearing rate
Seriously.At present, market has had started to disinfection sterilizing type ultrasonic coupling agent and has sold, but these couplants have existed fungicide effect not
Between good, composition, compatibility is unreasonable, easily to the instrument burn into infringement function of couplant own and stimulate that skin etc. is many asks
Topic.Prior art needs a kind of B ultrasonic couplant and preparation technology thereof.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art to provide a kind of B ultrasonic couplant and preparation technology, this coupling
Mixture stable performance, has the function of standby disinfection concurrently, non-stimulated to skin.
The present invention is achieved by the following technical solution:
A kind of B ultrasonic couplant, it is prepared by following raw material:
Propylene glycol, glycerol, hyaluronic acid, hydroxyethyl cellulose, sodium lauryl sulphate, vitamin E, deionized water, potassium iodide,
Carboxymethyl chitosan, Flos Lonicerae, black pepper；
Specifically, described couplant is prepared according to following technique:
Propylene glycol, glycerol and hyaluronic acid are mixed by step 1) according to the mass ratio of 20:15:2, and 500 turns/min stirs 5min,
Obtain mixed liquor；Being added by hydroxyethyl cellulose in above-mentioned mixed liquor, 500 turns/min stirs 3min, is heated to 60 DEG C, insulation
30min, is cooled to room temperature, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:100；
Step 2) sodium lauryl sulphate and vitamin E are added in deionized water successively, stir, obtain component B；Its
In, the mass ratio of sodium lauryl sulphate, vitamin E and deionized water is 3:2:200；
Step 3) is by step 2) obtained component B is heated to 50 DEG C, and add potassium iodide and carboxymethyl chitosan while stirring, obtain
Component C；Wherein, the mass ratio of potassium iodide, carboxymethyl chitosan and component B is 3-7:2-5:100-200；
Flos Lonicerae and black pepper are mixed by step 4) according to the mass ratio of 1:1, add and account for mixture double weight 85%(volume ratio)
Ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.1g/ml, and 60 DEG C dried,
Pulverize, cross 100 mesh sieves, obtain component D；
Component A, component D are added in component C by step 5) successively, and 300 turns/min stirs 15min, subpackage, seal and get final product.
In described step 5), the mass ratio of component A, component D and component C is 30-50:2-3:55-80.
The beneficial effect that the present invention obtains specifically includes that
The each components compatibility of couplant of the present invention is reasonable, and bubble is few, and entrant sound effect is notable, and ultra sonic imaging is clear, corrosion-free to probe,
Non-stimulated to skin, and possess disinfection function；Couplant of the present invention is safe and effective, can effectively kill the gold that hospital is common
The antibacterials such as Staphylococcus aureus, dysentery bacterium and escherichia coli, effect is high, and sterilizing time is short；The each physics and chemistry of couplant of the present invention refers to
Mark stable performance, has no crystallization, muddiness, precipitation during use, and the performance of every physical and chemical index is stable, and production cost is low,
Preparation technology is simple, process conditions are easily achieved；The present invention with the addition of plant extract as antibacterial, decreases chemical disinfection
The consumption of agent, compatibility synergy is good；Plant material of the present invention is readily available in locality, with low cost, and bactericidal effect is good.
Detailed description of the invention
For the technical scheme making those skilled in the art be more fully understood that in the application, have below in conjunction with the application
Body embodiment, more clearly and completely describes the present invention, it is clear that described embodiment is only the application one
Divide embodiment rather than whole embodiments.Based on the embodiment in the application, those of ordinary skill in the art are not making
The every other embodiment obtained under creative work premise, all should belong to the scope of protection of the invention.
Embodiment 1
A kind of B ultrasonic couplant, it is prepared by following raw material:
Propylene glycol, glycerol, hyaluronic acid, hydroxyethyl cellulose, sodium lauryl sulphate, vitamin E, deionized water, potassium iodide,
Carboxymethyl chitosan, Flos Lonicerae, black pepper；
Specifically, described couplant is prepared according to following technique:
Propylene glycol, glycerol and hyaluronic acid are mixed by step 1) according to the mass ratio of 20:15:2, and 500 turns/min stirs 5min,
Obtain mixed liquor；Being added by hydroxyethyl cellulose in above-mentioned mixed liquor, 500 turns/min stirs 3min, is heated to 60 DEG C, insulation
30min, is cooled to room temperature, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:100；
Step 2) sodium lauryl sulphate and vitamin E are added in deionized water successively, stir, obtain component B；Its
In, the mass ratio of sodium lauryl sulphate, vitamin E and deionized water is 3:2:200；
Step 3) is by step 2) obtained component B is heated to 50 DEG C, and add potassium iodide and carboxymethyl chitosan while stirring, obtain
Component C；Wherein, the mass ratio of potassium iodide, carboxymethyl chitosan and component B is 7:5:200；
Flos Lonicerae and black pepper are mixed by step 4) according to the mass ratio of 1:1, add and account for mixture double weight 85%(volume ratio)
Ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.1g/ml, and 60 DEG C dried,
Pulverize, cross 100 mesh sieves, obtain component D；
Component A, component D are added in component C by step 5) successively, and 300 turns/min stirs 15min, subpackage, seal and get final product.
In described step 5), the mass ratio of component A, component D and component C is 50:3:80.
Embodiment 2
A kind of B ultrasonic couplant, it is prepared by following raw material:
Propylene glycol, glycerol, hyaluronic acid, hydroxyethyl cellulose, sodium lauryl sulphate, vitamin E, deionized water, potassium iodide,
Carboxymethyl chitosan, Flos Lonicerae, black pepper；
Specifically, described couplant is prepared according to following technique:
Propylene glycol, glycerol and hyaluronic acid are mixed by step 1) according to the mass ratio of 20:15:2, and 500 turns/min stirs 5min,
Obtain mixed liquor；Being added by hydroxyethyl cellulose in above-mentioned mixed liquor, 500 turns/min stirs 3min, is heated to 60 DEG C, insulation
30min, is cooled to room temperature, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:100；
Step 2) sodium lauryl sulphate and vitamin E are added in deionized water successively, stir, obtain component B；Its
In, the mass ratio of sodium lauryl sulphate, vitamin E and deionized water is 3:2:200；
Step 3) is by step 2) obtained component B is heated to 50 DEG C, and add potassium iodide and carboxymethyl chitosan while stirring, obtain
Component C；Wherein, the mass ratio of potassium iodide, carboxymethyl chitosan and component B is 3:2:100；
Flos Lonicerae and black pepper are mixed by step 4) according to the mass ratio of 1:1, add and account for mixture double weight 85%(volume ratio)
Ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.1g/ml, and 60 DEG C dried,
Pulverize, cross 100 mesh sieves, obtain component D；
Component A, component D are added in component C by step 5) successively, and 300 turns/min stirs 15min, subpackage, seal and get final product.
In described step 5), the mass ratio of component A, component D and component C is 30:2:55.
Embodiment 3
Performance test:
As a example by the couplant of embodiment 1 preparation, after testing: outward appearance is colorless transparent gel shape, bubble-free, without insoluble in different
Thing, pH value is 6.9, and viscosity is 23Pa.s, and the velocity of sound is 1598m/s, and acoustic characteristic impedance is 1.6 × 1106Pa.s/m, acoustic attenuation is
0.029Db/ (cm.MHz), without hypersensitive, deposits half a year at 37 DEG C, and outward appearance has no crystallization, muddiness, precipitation, multiple correlation
Standard.
Bacteriostatic test is as follows:
Experimental strain: staphylococcus aureus, escherichia coli, dysentery bacterium, streptococcus pneumoniae.
Experiment flow: be inoculated into respectively in nutrient broth medium by four kinds of strains, cultivates 24 hours for 30 DEG C, separates bacterium
Liquid, is diluted to 1 × 108Individual/ml, then by four kinds of bacterium solution mixing, obtains mixed bacteria liquid, then takes 10ml mixed bacteria liquid and be placed in 10
In individual culture dish, labelling embodiment 1 group (5 culture dishs use the couplant of embodiment 1) and embodiment 2 groups (5 trainings respectively
Support ware, use the couplant of embodiment 2)；Couplant diluent of the present invention (diluting 10 times) is respectively dropped into test group culture dish；
Dripping quantity is 1ml/ culture dish；Have detected 30min each strain bacterium colony revolution mark result, be shown in Table 1:
Table 1
| Bacterium colony revolution mark (30min) | Staphylococcus aureus | Escherichia coli | Dysentery bacterium | Streptococcus pneumoniae |
| 1 group of % of embodiment | 17.9 | 16.7 | 15.2 | 15.3 |
| 2 groups of % of embodiment | 16.8 | 16.4 | 14.1 | 16.9 |
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, the present invention is not
It is limited to above example, it is also possible to have many deformation.Those of ordinary skill in the art can be direct from present disclosure
The all deformation derived or associate, are all considered as protection scope of the present invention.
Claims (4)
1. a B ultrasonic couplant, it is prepared by following raw material:
Propylene glycol, glycerol, hyaluronic acid, hydroxyethyl cellulose, sodium lauryl sulphate, vitamin E, deionized water, potassium iodide,
Carboxymethyl chitosan, Flos Lonicerae, black pepper.
Couplant the most according to claim 1, it is characterised in that described couplant is prepared according to following technique:
Propylene glycol, glycerol and hyaluronic acid are mixed by step 1) according to the mass ratio of 20:15:2, and 500 turns/min stirs 5min,
Obtain mixed liquor；Being added by hydroxyethyl cellulose in above-mentioned mixed liquor, 500 turns/min stirs 3min, is heated to 60 DEG C, insulation
30min, is cooled to room temperature, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:100；
Step 2) sodium lauryl sulphate and vitamin E are added in deionized water successively, stir, obtain component B；Its
In, the mass ratio of sodium lauryl sulphate, vitamin E and deionized water is 3:2:200；
Step 3) is by step 2) obtained component B is heated to 50 DEG C, and add potassium iodide and carboxymethyl chitosan while stirring, obtain
Component C；Wherein, the mass ratio of potassium iodide, carboxymethyl chitosan and component B is 3-7:2-5:100-200；
Flos Lonicerae and black pepper are mixed by step 4) according to the mass ratio of 1:1, add and account for mixture double weight 85%(volume ratio)
Ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.1g/ml, and 60 DEG C dried,
Pulverize, cross 100 mesh sieves, obtain component D；
Component A, component D are added in component C by step 5) successively, and 300 turns/min stirs 15min, subpackage, seal and get final product.
Couplant the most according to claim 2, it is characterised in that in described step 5), component A, component D and component C
Mass ratio be 30-50:2-3:55-80.
4. claim 1-3 is allowed to the preparation technology of couplant described in.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106540281A (en) * | 2016-12-08 | 2017-03-29 | 邓丽萍 | B ultrasonic couplant and its preparation technology |
| CN107158412A (en) * | 2017-04-28 | 2017-09-15 | 四川康源医疗设备有限公司 | B ultrasound couplant and preparation method thereof |
| CN108187074A (en) * | 2018-01-22 | 2018-06-22 | 山东嘉百通生物科技有限公司 | A kind of coupling agent for medical use and preparation method thereof |
| CN112834615A (en) * | 2020-12-31 | 2021-05-25 | 山东医学高等专科学校 | Ultrasonic coupling agent for railway steel rail flaw detection and preparation method thereof |
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| CN102580124A (en) * | 2012-03-16 | 2012-07-18 | 广东工业大学 | Medical disinfecting ultrasound gel composition and preparation method |
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| CN106540281A (en) * | 2016-12-08 | 2017-03-29 | 邓丽萍 | B ultrasonic couplant and its preparation technology |
| CN107158412A (en) * | 2017-04-28 | 2017-09-15 | 四川康源医疗设备有限公司 | B ultrasound couplant and preparation method thereof |
| CN108187074A (en) * | 2018-01-22 | 2018-06-22 | 山东嘉百通生物科技有限公司 | A kind of coupling agent for medical use and preparation method thereof |
| CN112834615A (en) * | 2020-12-31 | 2021-05-25 | 山东医学高等专科学校 | Ultrasonic coupling agent for railway steel rail flaw detection and preparation method thereof |
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Application publication date: 20160928 |