CN107537042A - A kind of special coupling lubricant of ultrasound diagnosis - Google Patents
A kind of special coupling lubricant of ultrasound diagnosis Download PDFInfo
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- CN107537042A CN107537042A CN201610462372.5A CN201610462372A CN107537042A CN 107537042 A CN107537042 A CN 107537042A CN 201610462372 A CN201610462372 A CN 201610462372A CN 107537042 A CN107537042 A CN 107537042A
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Abstract
The invention belongs to couplant technical field, discloses a kind of special coupling lubricant of ultrasound diagnosis, it is prepared according to following technique：Step 1）Prepare component A, step 2）Prepare component B, step 3）Prepare component C, step 4）Prepare component D, step 5）Prepare coupling lubricant.Present invention coupling lubricant properties are stable, have the function of standby disinfection concurrently.
Description
Technical field
The invention belongs to couplant technical field, and in particular to a kind of special coupling lubricant of ultrasound diagnosis.
Background technology
B ultrasound is the conventional diagnostic method of hospital.B ultrasound can clearly display each internal organs and the various sections of peripheral organs
Picture, because image is imbued with entity sense, close to the real structure of dissection, so can be clarified a diagnosis in early days using ultrasound.Ultrasound
Diagnostic equipment has various class, and advanced top-grade instrument is complicated, has high-performance, multi-functional, high-resolution and fine definition
The features such as.Their basic building block includes five parts such as transmitting, scanning, reception, signal transacting and display, and it is big to be divided into two
Part, i.e. main frame and probe.One main frame can have one, two or more probes, and can install 1 in a probe
Or dozens of forms an array element by 1 to several chips, taken turns successively down to more than thousand chips, such as real-time ultrasonic diagnostic probes
Flow work, transmitting and receive acoustic energy.Chip is made up of electrostriction material, serves as the energy conversion of electricity, sound, electricity, therefore also referred to as
Transducer.There are single-frequency, multifrequency and wideband probe by frequency.Ultrasonic real-time head is by the arrangement separated time battle array of piezoelectric chip, ring battle array, convex
Battle array etc., is there is body surface, intracavitary, various titles in pipe by purposes again, only several millimeters of some probes, can be into coronary artery.
Make us may be excellent for coupling agent for medical use and hospital's ultrasonic probe Bacteria carrying status at present.Ultrasonic probe in hospital's use is universal
Do not disinfect, only wiped after checking using white cotton paper, then carry out next inspection, and medical supersonic is visited
Head frequently contacts the different crowds such as physical examination of healthy population, patients with infectious diseases, dermatosis patient, infant, pregnant woman, in clinical examination
Probe often carries a variety of pathogenic microorganisms, the potential danger that medical cross infection be present, causes ultrasonic probe bacterial bearing rate
Seriously.At present, in the market has had started to the sale of disinfection sterilizing type ultrasonic coupling agent, but these couplants have fungicide effect not
Compatibility is unreasonable between good, composition, couplant function itself is easily damaged to instrument burn into and stimulates skin etc. is many to ask
Topic.Prior art needs a kind of special coupling lubricant of ultrasound diagnosis for possessing couplant function and sterilizing function.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art and provides a kind of ultrasound diagnosis special coupling lubricant, the coupling
Lubricant properties stabilization is closed, has the function of standby disinfection concurrently, it is non-stimulated to skin.
The present invention is achieved by the following technical solution：
A kind of special coupling lubricant of ultrasound diagnosis, it is prepared according to following technique：Step 1）Prepare component A, step 2）System
Standby component B, step 3）Prepare component C, step 4）Prepare component D, step 5）Prepare coupling lubricant；
Specifically, the coupling lubricant is prepared according to following technique：
Step 1）Prepare component A：By propane diols, glycerine and hyaluronic acid according to 10:8:1 mass ratio mixing, 300 turns/min
10min is stirred, obtains mixed liquor；Hydroxyethyl cellulose is added in above-mentioned mixed liquor, 500 turns/min stirring 3min, reheated
To 60 DEG C, 30min is incubated, room temperature is cooled to, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:
50；
Step 2）Prepare component B：Lauryl sodium sulfate and vitamin E are added in deionized water successively, stirred, is obtained
To component B；Wherein, the mass ratio of lauryl sodium sulfate, vitamin E and deionized water is 2:1:100；
Step 3）Prepare component C：By step 2）Obtained component B is heated to 50 DEG C, adds KI and carboxymethyl while stirring
Chitosan, obtain component C；Wherein, the mass ratio of KI, carboxymethyl chitosan and component B is 3-7:2-5:100-200；
Step 4）Prepare component D：By honeysuckle and black pepper according to 2-3:1-2 mass ratio mixing, addition account for mixture twice
Weight 85%（Volume ratio）Ethanol, refluxing extraction 2 times, every time 1 hour, extract solution merged, and it is 1.1g/ml to be concentrated into density
Medicinal extract, after 60 DEG C of dryings, crush, cross 100 mesh sieves, produce component D；
Step 5）Prepare coupling lubricant：Component A, component D are added in component C successively, 300 turns/min stirring 15min,
Dispense, seal and produce.
The step 5）In, component A, component D and component C mass ratio are 20-35:1-2:30-50
The beneficial effect that the present invention obtains mainly includes：
Present invention coupling each components compatibility of lubricant is reasonable, and bubble is few, and entrant sound significant effect, ultrasonic imaging is clear, to nothing of popping one's head in
Corrosion, it is non-stimulated to skin, and possess disinfection function；Present invention coupling lubricant is safe and effective, can effectively kill doctor
The bacteriums such as the common staphylococcus aureus of institute, shigella dysenteriae and Escherichia coli, effect is high, and sterilizing time is short；Present invention coupling
Each physical and chemical index stable performance of lubricant, crystallization, muddiness, precipitation are had no during use, every physical and chemical index performance is stable, and
And production cost is low, preparation technology is simple, process conditions are easily achieved；The present invention with the addition of plant extracts as bactericide,
Reduce the dosage of chemosterilant, compatibility synergy is good；Plant material of the present invention is readily available in locality, and cost is cheap,
Bactericidal effect is good.
Embodiment
In order that those skilled in the art more fully understand the technical scheme in the application, have below in conjunction with the application
Body embodiment, the present invention is more clearly and completely described, it is clear that described embodiment is only the application one
Divide embodiment, rather than whole embodiments.Based on the embodiment in the application, those of ordinary skill in the art are not making
The every other embodiment obtained under the premise of creative work, should all belong to the scope of protection of the invention.
Embodiment 1
A kind of special coupling lubricant of ultrasound diagnosis, it is prepared according to following technique：
Step 1）, by propane diols, glycerine and hyaluronic acid according to 10:8:1 mass ratio mixing, 300 turns/min stirrings
10min, obtain mixed liquor；Hydroxyethyl cellulose is added in above-mentioned mixed liquor, 500 turns/min stirring 3min, is heated to 60
DEG C, 30min is incubated, room temperature is cooled to, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:50；
Step 2）, lauryl sodium sulfate and vitamin E are added in deionized water successively, stirred, obtains component B；
Wherein, the mass ratio of lauryl sodium sulfate, vitamin E and deionized water is 2:1:100；
Step 3）, by step 2）Obtained component B is heated to 50 DEG C, adds KI and carboxymethyl chitosan while stirring, obtains
To component C；Wherein, the mass ratio of KI, carboxymethyl chitosan and component B is 7:5:200；
Step 4）, by honeysuckle and black pepper according to 2:1 mass ratio mixing, addition account for mixture double weight 85%（Volume
Than）Ethanol, refluxing extraction 2 times, 1 hour every time, extract solution merge, be concentrated into density be 1.1g/ml medicinal extract, 60 DEG C of dryings
Afterwards, crush, cross 100 mesh sieves, produce component D；
Step 5）, component A, component D are added in component C successively, 300 turns/min stirring 15min, dispenses, seal and produce；
Wherein, component A, component D and component C mass ratio are 20:1:30.
Embodiment 2
A kind of special coupling lubricant of ultrasound diagnosis, it is prepared according to following technique：
Step 1）, by propane diols, glycerine and hyaluronic acid according to 10:8:1 mass ratio mixing, 300 turns/min stirrings
10min, obtain mixed liquor；Hydroxyethyl cellulose is added in above-mentioned mixed liquor, 500 turns/min stirring 3min, is heated to 60
DEG C, 30min is incubated, room temperature is cooled to, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:50；
Step 2）, lauryl sodium sulfate and vitamin E are added in deionized water successively, stirred, obtains component B；
Wherein, the mass ratio of lauryl sodium sulfate, vitamin E and deionized water is 2:1:100；
Step 3）, by step 2）Obtained component B is heated to 50 DEG C, adds KI and carboxymethyl chitosan while stirring, obtains
To component C；Wherein, the mass ratio of KI, carboxymethyl chitosan and component B is 3:2:100；
Step 4）, by honeysuckle and black pepper according to 3:2 mass ratio mixing, addition account for mixture double weight 85%（Volume
Than）Ethanol, refluxing extraction 2 times, 1 hour every time, extract solution merge, be concentrated into density be 1.1g/ml medicinal extract, 60 DEG C of dryings
Afterwards, crush, cross 100 mesh sieves, produce component D；
Step 5）, component A, component D are added in component C successively, 300 turns/min stirring 15min, dispenses, seal and produce；
Wherein, component A, component D and component C mass ratio are 35:2:50.
Embodiment 3
Performance test：
By taking coupling lubricant prepared by embodiment 1 as an example, after testing：Outward appearance is in colorless transparent gel shape, bubble-free, without not dissolving in
Foreign matter, pH value 6.8, viscosity 22Pa.s, velocity of sound 1579m/s, acoustic characteristic impedance are 1.59 × 106Pa.s/m, acoustic attenuation
For 0.028Db/ (cm.MHz), no cytotoxicity, no hypersensitive, deposit half a year at 37 DEG C, outward appearance have no crystallization, muddiness,
Precipitation, meets relevant criterion.
Bacteriostatic test is as follows：
Experimental strain：Staphylococcus aureus, Escherichia coli, shigella dysenteriae, pneumococcus.
Experiment flow：Four kinds of strains are inoculated into nutrient broth medium respectively, 30 DEG C are cultivated 24 hours, separate bacterium
Liquid, it is diluted to 1 × 108Individual/ml, then four kinds of bacterium solutions are mixed, mixed bacteria liquid is obtained, then takes 10ml mixed bacteria liquids to be placed in 10
In individual culture dish, 1 group of embodiment is marked respectively（5 culture dishes, using the lubricant of embodiment 1）With 2 groups of embodiment（5 trainings
Ware is supported, using the lubricant of embodiment 2）；By lubricant dilution of the present invention（10 times of dilution）It is respectively dropped into test group culture dish；
Dripping quantity is 1ml/ culture dish；Each strain bacterium colony revolution mark results of 30min are have detected, are shown in Table 1：
Table 1
| Bacterium colony revolution mark（30min） | Staphylococcus aureus | Escherichia coli | Shigella dysenteriae | Pneumococcus |
| 1 group of % of embodiment | 19.3 | 16.2 | 14.7 | 15.8 |
| 2 groups of % of embodiment | 18.7 | 17.1 | 13.2 | 16.4 |
Finally, it is also necessary to it is noted that listed above is only several specific embodiments of the invention.Obviously, the present invention not
It is limited to above example, there can also be many deformations.One of ordinary skill in the art can be direct from present disclosure
All deformations for exporting or associating, are considered as protection scope of the present invention.
Claims (3)
1. a kind of special coupling lubricant of ultrasound diagnosis, it is prepared according to following technique：Step 1）Prepare component A, step 2）
Prepare component B, step 3）Prepare component C, step 4）Prepare component D, step 5）Prepare coupling lubricant.
2. coupling lubricant according to claim 1, it is characterised in that the coupling lubricant is prepared according to following technique
And obtain：
Step 1）Prepare component A：By propane diols, glycerine and hyaluronic acid according to 10:8:1 mass ratio mixing, 300 turns/min
10min is stirred, obtains mixed liquor；Hydroxyethyl cellulose is added in above-mentioned mixed liquor, 500 turns/min stirring 3min, reheated
To 60 DEG C, 30min is incubated, room temperature is cooled to, obtains component A；Wherein, the mass ratio of hydroxyethyl cellulose and mixed liquor is 1:
50；
Step 2）Prepare component B：Lauryl sodium sulfate and vitamin E are added in deionized water successively, stirred, is obtained
To component B；Wherein, the mass ratio of lauryl sodium sulfate, vitamin E and deionized water is 2:1:100；
Step 3）Prepare component C：By step 2）Obtained component B is heated to 50 DEG C, adds KI and carboxymethyl while stirring
Chitosan, obtain component C；Wherein, the mass ratio of KI, carboxymethyl chitosan and component B is 3-7:2-5:100-200；
Step 4）Prepare component D：By honeysuckle and black pepper according to 2-3:1-2 mass ratio mixing, addition account for mixture twice
Weight 85%（Volume ratio）Ethanol, refluxing extraction 2 times, every time 1 hour, extract solution merged, and it is 1.1g/ml to be concentrated into density
Medicinal extract, after 60 DEG C of dryings, crush, cross 100 mesh sieves, produce component D；
Step 5）Prepare coupling lubricant：Component A, component D are added in component C successively, 300 turns/min stirring 15min,
Dispense, seal and produce.
3. coupling lubricant according to claim 2, it is characterised in that the step 5）In, component A, component D and group
The mass ratio for dividing C is 20-35:1-2:30-50.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610462372.5A CN107537042A (en) | 2016-06-23 | 2016-06-23 | A kind of special coupling lubricant of ultrasound diagnosis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610462372.5A CN107537042A (en) | 2016-06-23 | 2016-06-23 | A kind of special coupling lubricant of ultrasound diagnosis |
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| CN101711882A (en) * | 2009-12-22 | 2010-05-26 | 上海上官医药科技有限公司 | Medical ultrasound coupling agent with function of fast and efficient sterilization and device thereof |
| CN101991868A (en) * | 2010-11-01 | 2011-03-30 | 江苏永发医用设备有限公司 | Sterilizing, disinfecting and skin-moisturizing medical ultrasonic coupling agent and preparation method thereof |
| CN102580124A (en) * | 2012-03-16 | 2012-07-18 | 广东工业大学 | Medical disinfecting ultrasound gel composition and preparation method |
| CN103893784A (en) * | 2014-03-18 | 2014-07-02 | 苏晓婷 | Disinfecting ultrasonic coupling agent and preparation method thereof |
| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
-
2016
- 2016-06-23 CN CN201610462372.5A patent/CN107537042A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711882A (en) * | 2009-12-22 | 2010-05-26 | 上海上官医药科技有限公司 | Medical ultrasound coupling agent with function of fast and efficient sterilization and device thereof |
| CN101991868A (en) * | 2010-11-01 | 2011-03-30 | 江苏永发医用设备有限公司 | Sterilizing, disinfecting and skin-moisturizing medical ultrasonic coupling agent and preparation method thereof |
| CN102580124A (en) * | 2012-03-16 | 2012-07-18 | 广东工业大学 | Medical disinfecting ultrasound gel composition and preparation method |
| CN104208726A (en) * | 2014-02-28 | 2014-12-17 | 张维芬 | Chitosan quaternary ammonium salt couplant and preparation method thereof |
| CN103893784A (en) * | 2014-03-18 | 2014-07-02 | 苏晓婷 | Disinfecting ultrasonic coupling agent and preparation method thereof |
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| 岳进等: "植物提取物抗菌作用及其在食品中的应用", 《上海交通大学学报》 * |
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Application publication date: 20180105 |