CN106620732A - Sterilization and disinfection type coupling agent and method for preparing same - Google Patents
Sterilization and disinfection type coupling agent and method for preparing same Download PDFInfo
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- CN106620732A CN106620732A CN201610909107.7A CN201610909107A CN106620732A CN 106620732 A CN106620732 A CN 106620732A CN 201610909107 A CN201610909107 A CN 201610909107A CN 106620732 A CN106620732 A CN 106620732A
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Abstract
The invention belongs to the technical field of medical coupling agents, and particularly relates to a sterilization and disinfection type coupling agent and a method for preparing the same. Active ingredients in the sterilization and disinfection type coupling agent are made of, by weight, 0.15-0.25 part of hydroxypropyl celluloses, 0.7-1.0 part of carbomer, 4-15 parts of propylene glycol, 82-95 parts of deionized water and 0.03-0.14 part of fungicides. The fungicides are made of, by weight, 20-30 parts of bigleaf fig bark, 15-25 parts of rhizoma anemarrhenae, 10-20 parts of fructus kochiae, 40-60 parts of bidens tripartita, 25-45 parts of aloe, 12-36 parts of sedum spectabile boreau, 10-16 parts of herba portulacae, 30-40 parts of ocimum basilicum, 15-35 parts of symplocos paniculata, 8-16 parts of herba andrographis, 16-26 parts of daphne giraldii nitsche, 20-28 parts of cactaceae, 30-40 parts of herba menthae, 14-28 parts of astragalus sinicus, 11-22 parts of cortex hibisci, 14-36 parts of rauvolfia verticillata, 16-30 parts of flos lonicerae and 15-30 parts of laminaria japonica. The sterilization and disinfection type coupling agent and the method have the advantages that the sterilization and disinfection type coupling agent can be used safely and comfortably, allergy reaction or cross infection can be prevented, and images are high in definition.
Description
(1) technical field
The invention belongs to coupling agent for medical use technical field, more particularly to a kind of bactericidal sterilization type couplant and its preparation side
Method.
(2) background technology
Couplant is a kind of water soluble polymer colloid, and it is for excluding the air between probe and testee, making
Ultrasonic wave energy effectively penetrates measured object and reaches effective detection purpose.Manifesting for Quality of acoustical image graphic directly indicates the good of couplant
It is bad, second-rate couplant cause ultrasonic energy losses, resolving power reduce, it is image blurring, or even stimulate skin and damage visit
Head.Clinically ultrasonic examination and treatment is required for using couplant, and the couplant of application is mainly gel component in semisolid, applies
Smear and can produce on patient skin sense of discomfort, many patients easily produce allergic reaction to it；Additionally, couplant and ultrasonic probe are matched somebody with somebody
During closing use, every time using finishing, ultrasonic probe is wiped generally by paper handkerchief, the couplant of residual is sudden and violent in atmosphere
Easily affected by external environment sanitary condition during dew, with air contact, easy breed bacteria, the viral miscellaneous bacteria of infection is given
Next time pollutes ultrasonic examination patient body using making troubles, easily, once patient's check point has wound, easily causes wound sense
Dye, to ultrasonic examination patient body health threat is brought.
(3) content of the invention
The present invention is in order to make up the deficiencies in the prior art, there is provided one kind is not susceptible to allergic reaction using safety, comfortable
And cross-infection, the high bactericidal sterilization type couplant of image definition and preparation method thereof, solve present in prior art
Problem.
The present invention is achieved through the following technical solutions：
A kind of bactericidal sterilization type couplant, its active component is prepared from the following raw materials in parts by weight：
Hydroxypropyl cellulose 0.15-0.25 parts, Carbomer 0.7-1.0 parts, propane diols 4-15 parts, deionized water 82-95 part,
Bactericide 0.03-0.14 parts；
The active component of the bactericide is prepared from the following raw materials in parts by weight：
Bigleaf fig bark 20-30 parts, wind-weed 15-25 parts, fruit of summer cypress 10-20 parts, bur beggar-ticks 40-60 parts, aloe 25-45 parts, scape
Its 12-36 part, purslane 10-16 parts, sweet basil 30-40 parts, Asiatic sweet leaf 15-35 parts, Herba Andrographitis 8-16 parts, girald daphne bark's 16-26 parts, celestial being
People's palm 20-28 parts, peppermint 30-40 parts, Chinese milk vetch 14-28 part, Cortex hibisus syriacus 11-22 parts, devilpepper 14-36 parts, honeysuckle 16-30
Part, sea-tangle 15-30 parts.
Preferably, the active component of the bactericidal sterilization type couplant is prepared from the following raw materials in parts by weight：
0.2 part of hydroxypropyl cellulose, 0.8 part of Carbomer, 10 parts of propane diols, 88 parts of deionized water, 0.07 part of bactericide；
The active component of the bactericide is prepared from the following raw materials in parts by weight：
25 parts of bigleaf fig bark, 20 parts of the wind-weed, 15 parts of the fruit of summer cypress, 50 parts of bur beggar-ticks, 35 parts of aloe, 24 parts of red-spotted stonecrop, purslane 13
Part, 35 parts of sweet basil, 25 parts of Asiatic sweet leaf, 12 parts of Herba Andrographitis, 21 parts of girald daphne bark, 24 parts of cactus, 35 parts of peppermint, 21 parts of Chinese milk vetch, wood
16 parts of rose of Sharon skin, 25 parts of devilpepper, 23 parts of honeysuckle, 22 parts of sea-tangle.
The preparation method of the bactericidal sterilization type couplant, including following operating procedure：
(1) by above-mentioned parts by weight, hydroxypropyl cellulose is distributed in propane diols, adds deionized water dispersed with stirring,
70-85 DEG C is heated to, 20-30min is incubated, to liquid-transparent, 40 DEG C is cooled to, insulation is standby；
(2) by above-mentioned parts by weight, bigleaf fig bark, the wind-weed, the fruit of summer cypress, bur beggar-ticks, purslane, sweet basil, Asiatic sweet leaf, punching are taken
Lotus, girald daphne bark, peppermint, Chinese milk vetch, Cortex hibisus syriacus, devilpepper, honeysuckle, aeration-drying 3-5 days is crushed, and crosses 400 mesh sieves, is obtained carefully
Powder A, it is standby；
(3) by above-mentioned parts by weight, aloe, red-spotted stonecrop, cactus and sea-tangle are taken, goes the removal of impurity, washed, dry up surface
Moisture, with slow fire 0.5-1h is fried, and takes out cooling, is placed in mortar and is smashed to pieces, is crossed 200 mesh sieves and is obtained fine powder B, standby；
(4) fine powder A obtained in step (2) and fine powder B obtained in step (3) are mixed, and adds 3 times of mixing fine powders weight
Ethanol immersion 1.5-3.5h, be heated to 40-50 DEG C extraction 2h, reclaim ethanol, filter to get filtrate, be concentrated to give paste, it is standby；
(5) by above-mentioned parts by weight, paste obtained in step (4) is added in the transparency liquid of step (1) insulation, is stirred
Mix uniform, cooling is canned, obtains final product.
The pharmaceutical characteristic of each composition of bactericide is as follows in bactericidal sterilization type couplant of the present invention：
Bigleaf fig bark：Nature and flavor：Picric acid, temperature.Indication：Control arthralgia due to wind-dampness, numb limb, hemiplegia, tinea sore.
The wind-weed：Nature and flavor：Hardship, trembles with fear.Enter lung, stomach, kidney channel.Indication：Nourishing Yin and falling fire, moisturize laxation.Control dysphoria with smothery sensation to quench one's thirst, bone
Steam labor heat, cough with lung heat, dry feces, difficult urination.
The fruit of summer cypress：Nature and flavor：Sweetness and bitterness, trembles with fear.Enter kidney, bladder warp.Indication：Diuresis, clearing away damp-heat.Difficult urination is controlled, is drenched
Disease, under band, hernia, rubella, sore, mange, private parts is wet to itch.
Bur beggar-ticks：Nature and flavor：Bitter sweet, puts down.Indication：Tracheitis is controlled, pulmonary tuberculosis, sphagitis, tonsillitis, dysentery is red
Poison, tinea sore.
Aloe：Nature and flavor：Hardship, trembles with fear.Enter liver, the heart, the spleen channel.Indication：Heat-clearing, defaecation, desinsection.Control constipation with heat retention, women
Amenorrhea, pediatric epilepsy scared, the hot malnutrition due to parasitic infestation of infantile malnutrition due to digestive disturbances or intestinalparasites, tinea sore, hemorrhoid complicated by anal fistula, atrophic rhinitis, scrofula.
Red-spotted stonecrop：Nature and flavor：Picric acid, trembles with fear.Enter meridian of Hand-SHAO YIN.Return liver warp.Indication：Heat-clearing, removing toxic substances, hemostasis.Erysipelas is controlled, is swum
Wind, dysphoria with smothery sensation shies mad, spitting of blood, haematemesis, treats sore, pyogenic infections, rubella, dermatitis rhus, the puckery pain of hot eyes, traumatism and bleeding.
Purslane：Nature and flavor：Acid, trembles with fear.Enter large intestine, liver, the spleen channel.Indication：It is clearing heat and detoxicating, dissipate blood detumescence.Control hot dysentery purulence
Blood, heat gonorrhea, blood strangury, under band, Carbuncle swells dislikes sore, erysipelas, trace scrofula.For damp and hot caused diarrhoea, dysentery, often with the coptis, the banksia rose.It is interior
Clothes smash juice external application, control carbuncle swells.Also be used for have blood in stool, uterine hemorrhage, have anastalsis.
Sweet basil：Nature and flavor：It is pungent, temperature.Start with, foot lunar, hand, Foot yangming Channel.Indication：Dispelling wind promoting the circulation of qi, dampness elimination helps digestion, living
Blood, removing toxic substances.Exogenous headache is controlled, food flatulence is stagnant, gastral cavity pain is had loose bowels, irregular menstruation, traumatic injury, snake bite and insect sting, skin wet sore, addiction
Rash itch.
Asiatic sweet leaf：Bitter, puckery, cold nature.Anti-inflammatory, softening hard masses, regulating the qi flowing in the channels.Indication：Scattered wind removing toxic substances.
Herba Andrographitis：Bitter, it is cold in nature, it is nontoxic.Enter the heart, the Jing of lung two.Indication：It is clearing heat and detoxicating, cool blood detumescence.Control acute bacterium
Dysentery, gastroenteritis, flu, epidemic meningitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, nosebleed epistaxis, oropharynx
Swell and ache, boil carbuncle swells, scald, venomous snake bite.
Girald daphne bark：Arduous, temperature is slightly poisonous.Indication：Dispelling wind and eliminating dampness, the pain-relieving powder for treating stasis of blood.Control arthralgia due to wind-dampness, numb limb,
Headache, stomachache, traumatic injury.
Cactus：Bitter, it is cool in nature.It is clearing heat and detoxicating, eliminating stasis to subdue swelling, benefiting stomach and stopping pain, antibechic.For taste-blindness rate,
Acute dysentery, cough；Mumps, mastitis, carbuncle furuncle poison, snake bite, burn and scald are controlled in external application.《Fujian east book on Chinese herbal medicine》Carry：
" energy stasis eliminatings, solution intestines poison, stomach invigorating, pain relieving, nourishing is stimulated the circulation of the blood and cause the muscles and joints to relax, hemostasis of curing the wound.Control blood under intestines wind anal fistula, lung carbuncle, stomachache, bruise
Damage.”
Peppermint：Nature and flavor：It is pungent, it is cool.Enter lung, Liver Channel.Indication：Dispelling wind, radiating, wards off dirty, detoxifies.Control affection of exogenous wind-heat, head
Bitterly, hot eyes, abscess of throat, food stagnation inflatable, aphtha, toothache, sore scabies, urticaria.
Chinese milk vetch：Indication：Blood circulation-activating eyesight-improving.Control eye part disease.
Cortex hibisus syriacus：Nature and flavor：Sweetness and bitterness, it is cool.Enter large intestine, liver, the spleen channel.Indication：Heat-clearing, dampness removing, removing toxic substances is antipruritic.Control intestines
Diarrhea due to wind-evil blood, dysentery, prolapse of the anus, leukorrhea, mange, hemorrhoid.
Devilpepper：Nature and flavor：Hardship, trembles with fear.Indication：Irascibility, detumescence poison, drop in clearing away wind heat.Cure cold heating, abscess of throat,
Hypertension Complicated Headache dizziness, acute filthy disease stomachache is vomited and diarrhoea, pruritus sore scabies.
Honeysuckle：It is sweet, it is cold in nature；Return lung, the heart, stomach.It is clearing heat and detoxicating.For warm disease heating, toxic-heat and blood stasis, large carbuncle swells
Poison, scrofula anal fistula.《Conventional Chinese herbal medicine handbook》Carry：It is " clearing heat and detoxicating.Control fever caused by exogenous pathogens cough, enteritis, bacillary dysentery, measles, the parotid gland
Inflammation, septicemia, sore furuncle poison, appendicitis, trauma infection contamination, children's miliaria poison.Cold tea is made, heatstroke, flu and enteron aisle can be prevented to pass
Catch an illness." modern medicine study confirms that honeysuckle has antibacterial action.
Sea-tangle：Nature and flavor：It is salty, tremble with fear.Indication：Softening and eliminating sputum, Li Shui expels the heat-evil.Control goiter and tumor tuberculosis, hernia lump in the abdomen, oedema, tinea pedis.
Above-mentioned each traditional Chinese medicine ingredients cooperate, and compatibility is suitable, using its mutual collaboration and resistant function, incorporate biography
The effect of system medicinal material greasy skin, antibiotic and sterilizing, promoting blood circulation to remove blood stasis, be respectively supplement, to no skin irritation, without sensitization, cost
It is low, good stability；Above-mentioned each traditional Chinese medicine ingredients are obtained into bactericide using the preparation method of the present invention, then with the hydroxypropyl of the present invention
The couplant that base cellulose, Carbomer, propane diols, deionized water are mixed with, with more preferable coupling, entrant sound effect is more
Plus significantly, ultrasonic imaging becomes apparent from, it is ensured that the cleaning of ultrasonic instrument, health during use, and can avoid iatrogenic
Cross-infection, eliminates the probability of skin infection when patient has wound, has preferably sterilized, Disinfection Effect to patient skin,
After ultrasound terminates, the bactericidal sterilization type couplant residued on patient skin can form a very thin protective layer, without the need for extra
Cleaning, can play skin care, water conservation moisturizing, effect that is anti-drying, promoting skin surface health, be widely popularized on clinic
Using.
(4) specific embodiment
With reference to embodiment, the invention will be further described, but the invention is not limited in this.
Embodiment 1：
The bactericidal sterilization type couplant, its active component is made up of the raw material of following weight：
Hydroxypropyl cellulose 0.2Kg, Carbomer 0.8Kg, propane diols 10Kg, deionized water 88Kg, bactericide 0.07Kg；
The active component of the bactericide is made up of the raw material of following weight：
Bigleaf fig bark 25Kg, wind-weed 20Kg, fruit of summer cypress 15Kg, bur beggar-ticks 50Kg, aloe 35Kg, red-spotted stonecrop 24Kg, purslane
13Kg, sweet basil 35Kg, Asiatic sweet leaf 25Kg, Herba Andrographitis 12Kg, girald daphne bark 21Kg, cactus 24Kg, peppermint 35Kg, Chinese milk vetch 21Kg,
Cortex hibisus syriacus 16Kg, devilpepper 25Kg, honeysuckle 23Kg, sea-tangle 22Kg.
The preparation method of above-mentioned bactericidal sterilization type couplant, including following operating procedure：
(1) by above-mentioned weight, hydroxypropyl cellulose is distributed in propane diols, adds deionized water dispersed with stirring, heating
To 76 DEG C, 25min is incubated, to liquid-transparent, is cooled to 40 DEG C, insulation is standby；
(2) by above-mentioned weight, bigleaf fig bark, the wind-weed, the fruit of summer cypress, bur beggar-ticks, purslane, sweet basil, Asiatic sweet leaf, Herba Andrographitis, ancestral are taken
Teacher fiber crops, peppermint, Chinese milk vetch, Cortex hibisus syriacus, devilpepper, honeysuckle, aeration-drying 4 days is crushed, and crosses 400 mesh sieves, obtains fine powder A, standby
With；
(3) by above-mentioned weight, aloe, red-spotted stonecrop, cactus and sea-tangle are taken, goes the removal of impurity, washed, dry up surface water
Point, 0.8h is fried with slow fire, cooling is taken out, it is placed in mortar and smashs to pieces, cross 200 mesh sieves and obtain fine powder B, it is standby；
(4) fine powder A obtained in step (2) and fine powder B obtained in step (3) are mixed, and adds 3 times of mixing fine powders weight
Ethanol immersion 2.5h, be heated to 40-50 DEG C extraction 2h, reclaim ethanol, filter to get filtrate, be concentrated to give paste, it is standby；
(5) by above-mentioned weight, paste obtained in step (4) is added in the transparency liquid of step (1) insulation, stirring is equal
Even, cooling is canned, obtains final product.
Embodiment 2：
The bactericidal sterilization type couplant, its active component is made up of the raw material of following weight：
Hydroxypropyl cellulose 0.15Kg, Carbomer 0.7Kg, propane diols 4Kg, deionized water 82Kg, bactericide 0.03Kg；
The active component of the bactericide is made up of the raw material of following weight：
Bigleaf fig bark 20Kg, wind-weed 15Kg, fruit of summer cypress 10Kg, bur beggar-ticks 40Kg, aloe 25Kg, red-spotted stonecrop 12Kg, purslane
10Kg, sweet basil 30Kg, Asiatic sweet leaf 15Kg, Herba Andrographitis 8Kg, girald daphne bark 16Kg, cactus 20Kg, peppermint 30Kg, Chinese milk vetch 14Kg, wood
Rose of Sharon skin 11Kg, devilpepper 14Kg, honeysuckle 16Kg, sea-tangle 15Kg.
The preparation method of above-mentioned bactericidal sterilization type couplant, including following operating procedure：
(1) by above-mentioned weight, hydroxypropyl cellulose is distributed in propane diols, adds deionized water dispersed with stirring, heating
To 70 DEG C, 20min is incubated, to liquid-transparent, is cooled to 40 DEG C, insulation is standby；
(2) by above-mentioned weight, bigleaf fig bark, the wind-weed, the fruit of summer cypress, bur beggar-ticks, purslane, sweet basil, Asiatic sweet leaf, Herba Andrographitis, ancestral are taken
Teacher fiber crops, peppermint, Chinese milk vetch, Cortex hibisus syriacus, devilpepper, honeysuckle, aeration-drying 3 days is crushed, and crosses 400 mesh sieves, obtains fine powder A, standby
With；
(3) by above-mentioned weight, aloe, red-spotted stonecrop, cactus and sea-tangle are taken, goes the removal of impurity, washed, dry up surface water
Point, 0.5h is fried with slow fire, cooling is taken out, it is placed in mortar and smashs to pieces, cross 200 mesh sieves and obtain fine powder B, it is standby；
(4) fine powder A obtained in step (2) and fine powder B obtained in step (3) are mixed, and adds 3 times of mixing fine powders weight
Ethanol immersion 1.5h, be heated to 40-50 DEG C extraction 2h, reclaim ethanol, filter to get filtrate, be concentrated to give paste, it is standby；
(5) by above-mentioned weight, paste obtained in step (4) is added in the transparency liquid of step (1) insulation, stirring is equal
Even, cooling is canned, obtains final product.
Embodiment 3：
The bactericidal sterilization type couplant, its active component is made up of the raw material of following weight：
Hydroxypropyl cellulose 0.25Kg, Carbomer 1.0Kg, propane diols 15Kg, deionized water 95Kg, bactericide 0.14Kg；
The active component of the bactericide is made up of the raw material of following weight：
Bigleaf fig bark 30Kg, wind-weed 25Kg, fruit of summer cypress 20Kg, bur beggar-ticks 60Kg, aloe 45Kg, red-spotted stonecrop 36Kg, purslane
16Kg, sweet basil 40Kg, Asiatic sweet leaf 35Kg, Herba Andrographitis 16Kg, girald daphne bark 26Kg, cactus 28Kg, peppermint 40Kg, Chinese milk vetch 28Kg,
Cortex hibisus syriacus 22Kg, devilpepper 36Kg, honeysuckle 30Kg, sea-tangle 30Kg.
The preparation method of above-mentioned bactericidal sterilization type couplant, including following operating procedure：
(1) by above-mentioned weight, hydroxypropyl cellulose is distributed in propane diols, adds deionized water dispersed with stirring, heating
To 85 DEG C, 30min is incubated, to liquid-transparent, is cooled to 40 DEG C, insulation is standby；
(2) by above-mentioned weight, bigleaf fig bark, the wind-weed, the fruit of summer cypress, bur beggar-ticks, purslane, sweet basil, Asiatic sweet leaf, Herba Andrographitis, ancestral are taken
Teacher fiber crops, peppermint, Chinese milk vetch, Cortex hibisus syriacus, devilpepper, honeysuckle, aeration-drying 3-5 days is crushed, and crosses 400 mesh sieves, obtains fine powder A, standby
With；
(3) by above-mentioned weight, aloe, red-spotted stonecrop, cactus and sea-tangle are taken, goes the removal of impurity, washed, dry up surface water
Point, 1h is fried with slow fire, cooling is taken out, it is placed in mortar and smashs to pieces, cross 200 mesh sieves and obtain fine powder B, it is standby；
(4) fine powder A obtained in step (2) and fine powder B obtained in step (3) are mixed, and adds 3 times of mixing fine powders weight
Ethanol immersion 3.5h, be heated to 40-50 DEG C extraction 2h, reclaim ethanol, filter to get filtrate, be concentrated to give paste, it is standby；
(5) by above-mentioned weight, paste obtained in step (4) is added in the transparency liquid of step (1) insulation, stirring is equal
Even, cooling is canned, obtains final product.
Embodiment 4：
The bactericidal sterilization type couplant, its active component is made up of the raw material of following weight：
Hydroxypropyl cellulose 0.18Kg, Carbomer 0.8Kg, propane diols 7Kg, deionized water 84Kg, bactericide 0.05Kg；
The active component of the bactericide is made up of the raw material of following weight：
Bigleaf fig bark 22Kg, wind-weed 18Kg, fruit of summer cypress 12Kg, bur beggar-ticks 45Kg, aloe 30Kg, red-spotted stonecrop 18Kg, purslane
11Kg, sweet basil 32Kg, Asiatic sweet leaf 20Kg, Herba Andrographitis 10Kg, girald daphne bark 18Kg, cactus 22Kg, peppermint 32Kg, Chinese milk vetch 17Kg,
Cortex hibisus syriacus 12Kg, devilpepper 19Kg, honeysuckle 19Kg, sea-tangle 18Kg.
The preparation method of above-mentioned bactericidal sterilization type couplant, including following operating procedure：
(1) by above-mentioned weight, hydroxypropyl cellulose is distributed in propane diols, adds deionized water dispersed with stirring, heating
To 82 DEG C, 26min is incubated, to liquid-transparent, is cooled to 40 DEG C, insulation is standby；
(2) by above-mentioned weight, bigleaf fig bark, the wind-weed, the fruit of summer cypress, bur beggar-ticks, purslane, sweet basil, Asiatic sweet leaf, Herba Andrographitis, ancestral are taken
Teacher fiber crops, peppermint, Chinese milk vetch, Cortex hibisus syriacus, devilpepper, honeysuckle, aeration-drying 3-5 days is crushed, and crosses 400 mesh sieves, obtains fine powder A, standby
With；
(3) by above-mentioned weight, aloe, red-spotted stonecrop, cactus and sea-tangle are taken, goes the removal of impurity, washed, dry up surface water
Point, 0.8h is fried with slow fire, cooling is taken out, it is placed in mortar and smashs to pieces, cross 200 mesh sieves and obtain fine powder B, it is standby；
(4) fine powder A obtained in step (2) and fine powder B obtained in step (3) are mixed, and adds 3 times of mixing fine powders weight
Ethanol immersion 3.2h, be heated to 40-50 DEG C extraction 2h, reclaim ethanol, filter to get filtrate, be concentrated to give paste, it is standby；
(5) by above-mentioned weight, paste obtained in step (4) is added in the transparency liquid of step (1) insulation, stirring is equal
Even, cooling is canned, obtains final product.
Embodiment 5：
The bactericidal sterilization type couplant, its active component is made up of the raw material of following weight：
Hydroxypropyl cellulose 0.22Kg, Carbomer 0.9Kg, propane diols 12Kg, deionized water 90Kg, bactericide 0.12Kg；
The active component of the bactericide is made up of the raw material of following weight：
Bigleaf fig bark 28Kg, wind-weed 22Kg, fruit of summer cypress 18Kg, bur beggar-ticks 55Kg, aloe 40Kg, red-spotted stonecrop 30Kg, purslane
15Kg, sweet basil 38Kg, Asiatic sweet leaf 30Kg, Herba Andrographitis 14Kg, girald daphne bark 23Kg, cactus 26Kg, peppermint 38Kg, Chinese milk vetch 24Kg,
Cortex hibisus syriacus 17Kg, devilpepper 30Kg, honeysuckle 26Kg, sea-tangle 26Kg.
The preparation method of above-mentioned bactericidal sterilization type couplant, including following operating procedure：
(1) by above-mentioned weight, hydroxypropyl cellulose is distributed in propane diols, adds deionized water dispersed with stirring, heating
To 80 DEG C, 26min is incubated, to liquid-transparent, is cooled to 40 DEG C, insulation is standby；
(2) by above-mentioned weight, bigleaf fig bark, the wind-weed, the fruit of summer cypress, bur beggar-ticks, purslane, sweet basil, Asiatic sweet leaf, Herba Andrographitis, ancestral are taken
Teacher fiber crops, peppermint, Chinese milk vetch, Cortex hibisus syriacus, devilpepper, honeysuckle, aeration-drying 3-5 days is crushed, and crosses 400 mesh sieves, obtains fine powder A, standby
With；
(3) by above-mentioned weight, aloe, red-spotted stonecrop, cactus and sea-tangle are taken, goes the removal of impurity, washed, dry up surface water
Point, 0.7h is fried with slow fire, cooling is taken out, it is placed in mortar and smashs to pieces, cross 200 mesh sieves and obtain fine powder B, it is standby；
(4) fine powder A obtained in step (2) and fine powder B obtained in step (3) are mixed, and adds 3 times of mixing fine powders weight
Ethanol immersion 2.8h, be heated to 40-50 DEG C extraction 2h, reclaim ethanol, filter to get filtrate, be concentrated to give paste, it is standby；
(5) by above-mentioned weight, paste obtained in step (4) is added in the transparency liquid of step (1) insulation, stirring is equal
Even, cooling is canned, obtains final product.
Clinical data：
1st, ultrasonic medical 500 clinical observations of patient, patient are selected to be randomly divided into two groups, experimental group 250, the wherein male sex
125, women 125, age 6-70 year；Control group 250, the wherein male sex 125, women 125, age 5-72.Two groups
Qualifications and record of service are basically identical, without significant difference, with comparativity.
When the 2nd, carrying out ultrasonic medical, experimental group patient uses bactericidal sterilization type couplant of the present invention, control group to use LJ-
OHJ coupling agent for medical use (Shandong pleasure gold), both are strictly used by operation instructions requirement.
3rd, 500 patients are divided into 3 big groups, allergic reaction, trauma infection contamination and image during ultrasonic medical is carried out respectively
Definition is observed, the comparison is as follows table 1-3：
Table 1
Table 2
Table 3
Shown with upper table 1-3 result, the using effect of bactericidal sterilization type couplant of the present invention is apparently higher than right in experimental group
According to group, bactericidal sterilization type couplant of the present invention can play a protective role to allergic constitution patient, it is to avoid anaphylactoid generation, increase
Plus comfort level during patient's ultrasonic medical；Bactericidal sterilization type couplant of the present invention is avoided that traumatic patient is being used in experimental group
During infection, it is ensured that safety；Image definition when carrying out ultrasonic medical using bactericidal sterilization type couplant of the present invention is more
It is high.
Model case：
1st, text certain, female, 36 years old, teacher belonged to allergic constitution, is four months pregnant, and customary B ultrasonic produces inspection, for B ultrasonic process makes
There is severe allergic reaction in couplant, trouble and discomfort are checked every time.Afterwards using the sterilizing of the embodiment of the present invention 1
Type couplant, using it product inspection is carried out, and Mrs's Wen skin and body have no rejection, and just trust carries out product inspection since then.
2nd, Zhang, man, 38 years old, businessman, once large-area burns, skin damage was serious, and doctor during its Ultrasonic Diagnosis to using
Couplant after use, wound infects, and necrosis occurs, is to coordinate diagnosis, and doctor uses the embodiment of the present invention 2 to it
Bactericidal sterilization type couplant, after diagnosis and treatment, without deterioration at skin infection, and gradually heal.
3rd, Cai, female 27 years old, doctor belongs to allergic constitution, is four months pregnant, and customary B ultrasonic produces inspection, for B ultrasonic process is used
Couplant there is severe allergic reaction, trouble and uncomfortable is checked every time.Afterwards using the bactericidal sterilization type of the embodiment of the present invention 3
Couplant, its skin and body have no rejection.
4th, Lee, man 42 years old, driver was once injured in driving procedure, and skin has damage, and fracture heals, and doctor is to its ultrasound
After use, wound infects the couplant used during diagnosis, and necrosis occurs；The embodiment of the present invention is used in doctor to it
After 4 bactericidal sterilization type couplant, without deterioration at skin infection, and gradually heal.
5th, Zhao, female, 21 years old, student, after ultrasonic examination is carried out, there is red rash thing and with itch in check point,
Use the bactericidal sterilization type couplant of the embodiment of the present invention 5 to it afterwards, above-mentioned symptom do not occur.
6th, Lee, man, 38 years old, patient realized that check point has stronger sense of discomfort, afterwards to it after ultrasonic examination is carried out
Using the bactericidal sterilization type couplant of the embodiment of the present invention 1, do not occur malaise symptoms again.
Claims (3)
1. a kind of bactericidal sterilization type couplant, is characterized in that：Its active component is prepared from the following raw materials in parts by weight：
Hydroxypropyl cellulose 0.15-0.25 parts, Carbomer 0.7-1.0 parts, propane diols 4-15 parts, deionized water 82-95 part, sterilization
Agent 0.03-0.14 parts；
The active component of the bactericide is prepared from the following raw materials in parts by weight：
Bigleaf fig bark 20-30 parts, wind-weed 15-25 parts, fruit of summer cypress 10-20 parts, bur beggar-ticks 40-60 parts, aloe 25-45 parts, red-spotted stonecrop 12-
36 parts, purslane 10-16 parts, sweet basil 30-40 parts, Asiatic sweet leaf 15-35 parts, Herba Andrographitis 8-16 parts, girald daphne bark's 16-26 parts, cactus
20-28 parts, peppermint 30-40 parts, Chinese milk vetch 14-28 part, Cortex hibisus syriacus 11-22 parts, devilpepper 14-36 parts, honeysuckle 16-30 parts,
Sea-tangle 15-30 parts.
2. a kind of bactericidal sterilization type couplant according to claim 1, is characterized in that：Its active component is by following weight portion
Several raw materials are made：
0.2 part of hydroxypropyl cellulose, 0.8 part of Carbomer, 10 parts of propane diols, 88 parts of deionized water, 0.07 part of bactericide；
The active component of the bactericide is prepared from the following raw materials in parts by weight：
25 parts of bigleaf fig bark, 20 parts of the wind-weed, 15 parts of the fruit of summer cypress, 50 parts of bur beggar-ticks, 35 parts of aloe, 24 parts of red-spotted stonecrop, 13 parts of purslane, sieve
35 parts of Le, 25 parts of Asiatic sweet leaf, 12 parts of Herba Andrographitis, 21 parts of girald daphne bark, 24 parts of cactus, 35 parts of peppermint, 21 parts of Chinese milk vetch, Cortex hibisus syriacus
13Kg, 25 parts of devilpepper, 23 parts of honeysuckle, 22 parts of sea-tangle.
3. a kind of preparation method of bactericidal sterilization type couplant according to claim 1 and 2, is characterized in that：Including as follows
Operating procedure：
(1) by above-mentioned parts by weight, hydroxypropyl cellulose is distributed in propane diols, adds deionized water dispersed with stirring, heating
To 70-85 DEG C, 20-30min is incubated, to liquid-transparent, is cooled to 40 DEG C, insulation is standby；
(2) by above-mentioned parts by weight, bigleaf fig bark, the wind-weed, the fruit of summer cypress, bur beggar-ticks, purslane, sweet basil, Asiatic sweet leaf, Herba Andrographitis, ancestral are taken
Teacher fiber crops, peppermint, Chinese milk vetch, Cortex hibisus syriacus, devilpepper, honeysuckle, aeration-drying 3-5 days is crushed, and crosses 400 mesh sieves, obtains fine powder A, standby
With；
(3) by above-mentioned parts by weight, aloe, red-spotted stonecrop, cactus and sea-tangle are taken, goes the removal of impurity, washed, dry up surface water
Point, 0.5-1h is fried with slow fire, cooling is taken out, it is placed in mortar and smashs to pieces, cross 200 mesh sieves and obtain fine powder B, it is standby；
(4) fine powder A obtained in step (2) and fine powder B obtained in step (3) are mixed, and adds the second of 3 times of mixing fine powders weight
Alcohol soaks 1.5-3.5h, is heated to 40-50 DEG C of extraction 2h, reclaims ethanol, filters to get filtrate, and is concentrated to give paste, standby；
(5) by above-mentioned parts by weight, paste obtained in step (4) is added in the transparency liquid of step (1) insulation, stirring is equal
Even, cooling is canned, obtains final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010851A (en) * | 2018-08-24 | 2018-12-18 | 广州恒腾电子科技有限公司 | Coupling agent for ultrasonic detection |
| CN112107699A (en) * | 2020-09-24 | 2020-12-22 | 青岛大学附属医院 | Edible esophagus ultrasonic coupling agent and preparation method thereof |
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| CN101612408A (en) * | 2009-07-24 | 2009-12-30 | 赵敬民 | B ultrasonic couplant and preparation method |
| CN103341184A (en) * | 2013-07-31 | 2013-10-09 | 王玉梅 | Ultrasonic coupling agent and preparation method thereof |
| CN103638535A (en) * | 2013-12-04 | 2014-03-19 | 夏青 | B ultrasound coupling agent containing traditional Chinese components |
| CN103751812A (en) * | 2014-01-19 | 2014-04-30 | 孙方利 | Ultrasonic couplant and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101612408A (en) * | 2009-07-24 | 2009-12-30 | 赵敬民 | B ultrasonic couplant and preparation method |
| CN103341184A (en) * | 2013-07-31 | 2013-10-09 | 王玉梅 | Ultrasonic coupling agent and preparation method thereof |
| CN103638535A (en) * | 2013-12-04 | 2014-03-19 | 夏青 | B ultrasound coupling agent containing traditional Chinese components |
| CN103751812A (en) * | 2014-01-19 | 2014-04-30 | 孙方利 | Ultrasonic couplant and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010851A (en) * | 2018-08-24 | 2018-12-18 | 广州恒腾电子科技有限公司 | Coupling agent for ultrasonic detection |
| CN112107699A (en) * | 2020-09-24 | 2020-12-22 | 青岛大学附属医院 | Edible esophagus ultrasonic coupling agent and preparation method thereof |
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