CN104645360A - Coupling agent for B-mode ultrasound ultrasonography and preparation method thereof - Google Patents

Abstract

The invention relates to a coupling agent and a preparation method thereof and particularly relates to a coupling agent for B-mode ultrasound ultrasonography and a preparation method thereof. The coupling agent is prepared from the following raw materials: radix sophorae flavescentis, purple perilla, radix bupleuri, herba artemisiae capillariae, cortex moutan, cortex phellodendri, sweet wormwood herb, flos chrysanthemi indici, rhizoma corydalis, embelia laeta, spica prunellae, climbing groundsel herb, conyza blinii, rhizoma anemarrhenae, glycerin, xanthan gum, sodium carboxymethylcellulose, propanetriol and deionized water. The coupling agent provided by the invention has the advantages that (1) the contained traditional Chinese medicine antibacterial component has a remarkably strong killing effect on gram positive and negative bacteria and can effectively prevent pathogenic bacteria on an ultrasonic diagnosis probe from causing cross infection to the use of a postoperative patient; (2) the coupling agent has a disinfection function same as a disinfectant, does not hurt the skin or a wound and also has a function of promoting healing; (3) a good B-ultrasound window can be formed on the wound surface, and each layer of the subcutaneous structure of the operative wound of the patient can be displayed well; and (4) the scheme is novel, the cost is low and the preparation is simple.

Description

A kind of B ultrasonic couplant and preparation method thereof

Technical field

The present invention relates to a kind of couplant and preparation method thereof, be specifically related to a kind of B ultrasonic couplant and preparation method thereof.

Background technology

Ultrasonic probe altofrequency in current ultrasonic examination uses repeatedly between patient, usually just after patient uses, simple wiping is done, although not necessarily make patient's infection pathogen thus, but still there is the risk of very large cross infection, when carrying out ultrasound detection, because ultrasonic probe must the skin of close contact patient just can check, many pathogenic bacterias can carry out cross infection by the damaged mouth of patient skin, especially detection position skin surface damages with wound or other forms, can bring cross infection with ultrasonic examination to patient.The basic reason of cross infection is caused by the pathogenic bacteria of carrying ultrasonic probe, what we did now is mostly with toilet paper by the dirt wiping on probe to perusal less than, if the intact patient of skin, pathogenic bacteria is difficult to enter in body, but the patient running into postoperative skin breakage just easily causes infection.Therefore, this kind of patient preferably when detecting, can sterilize to the skin of detected part in real time.Present common disinfectants type mostly is chlorine-containing disinfectant, peroxide disinfectant, aldehyde disinfectant, alcohol disinfectant, iodine-containing disinfectant, disinfectant phenolic, oxirane, biguanides disinfectant and quaternary ammonium disinfectant.These disinfectant are difficult to the reason be applied on B ultrasonic: one, common disinfectant contact skin, residual harmful, as teratogenesis, carcinogenic, irritated, zest etc.And the safety of patient, health perception are more and more stronger, country is more and more stricter for the requirement of safety and Health aspect.Two, common at present powerful disinfectant, often character is active, can with pathogen effect, also can with human response, can also react with the material of ultrasonic probe, the service life that impact is popped one's head in.Three, the active character of disinfectant is often reacted with probe and couplant, thus affects the technical specification of ultrasonics.Four, on the basis overcome the above problems, be difficult to reach fast, strong bactericidal sterilization.Because the frequent use of probe, the interval between tested patient is short, often requires to complete sterilization within 1 to 3 minute.

Summary of the invention

According to above the deficiencies in the prior art, the invention provides a kind of B ultrasonic couplant and preparation method thereof, by adding antimicrobial form Chinese medicine ingredients in couplant, sterilizing can be completed in the short time, preventing the generation of cross infection.

A kind of B ultrasonic couplant of the present invention, according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.0 ~ 1.25%, Folium Perillae 0.35 ~ 0.75%, Radix Bupleuri 0.35 ~ 0.75%, Herba Artemisiae Scopariae 0.2 ~ 0.4%, Cortex Moutan 0.35 ~ 0.75%, Cortex Phellodendri 0.5 ~ 0.8%, Herba Artemisiae Annuae 0.5 ~ 0.8%, Flos Chrysanthemi Indici 1.0 ~ 1.25%, Rhizoma Corydalis 0.5 ~ 0.8%, Radix embeliae laetae 0.5 ~ 0.8%, Spica Prunellae 0.35 ~ 0.75%, Herba Senecionis Scandentis 0.6 ~ 0.9%, conyza blinii 0.6 ~ 0.9%, the Rhizoma Anemarrhenae 0.6 ~ 0.9%, glycerol 5 ~ 15%, xanthan gum 5 ~ 8%, sodium carboxymethyl cellulose 3 ~ 6%, glycerol 10 ~ 15%, surplus is deionized water.

Wherein, preferred version is as follows:

According to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.0%, Folium Perillae 0.35%, Radix Bupleuri 0.35%, Herba Artemisiae Scopariae 0.2%, Cortex Moutan 0.35%, Cortex Phellodendri 0.5%, Herba Artemisiae Annuae 0.5%, Flos Chrysanthemi Indici 1.0%, Rhizoma Corydalis 0.5%, Radix embeliae laetae 0.5%, Spica Prunellae 0.35%, Herba Senecionis Scandentis 0.6%, conyza blinii 0.6%, the Rhizoma Anemarrhenae 0.6%, glycerol 5%, xanthan gum 5%, sodium carboxymethyl cellulose 3%, glycerol 10%, surplus is deionized water.

According to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.25%, Folium Perillae 0.75%, Radix Bupleuri 0.75%, Herba Artemisiae Scopariae 0.4%, Cortex Moutan 0.75%, Cortex Phellodendri 0.8%, Herba Artemisiae Annuae 0.8%, Flos Chrysanthemi Indici 1.25%, Rhizoma Corydalis 0.8%, Radix embeliae laetae 0.8%, Spica Prunellae 0.75%, Herba Senecionis Scandentis 0.9%, conyza blinii 0.9%, the Rhizoma Anemarrhenae 0.9%, glycerol 15%, xanthan gum 8%, sodium carboxymethyl cellulose 6%, glycerol 15%, surplus is deionized water.

According to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.1%, Folium Perillae 0.5%, Radix Bupleuri 0.5%, Herba Artemisiae Scopariae 0.3%, Cortex Moutan 0.5%, Cortex Phellodendri 0.6%, Herba Artemisiae Annuae 0.6%, Flos Chrysanthemi Indici 1.1%, Rhizoma Corydalis 0.6%, Radix embeliae laetae 0.6%, Spica Prunellae 0.5%, Herba Senecionis Scandentis 0.8%, conyza blinii 0.8%, the Rhizoma Anemarrhenae 0.8%, glycerol 10%, xanthan gum 7%, sodium carboxymethyl cellulose 5%, glycerol 12%, surplus is deionized water.

The preparation method of B ultrasonic couplant of the present invention, carry out according to following steps:

(1) Radix Sophorae Flavescentis, Folium Perillae, Radix Bupleuri, Herba Artemisiae Scopariae, Cortex Moutan, Cortex Phellodendri, Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Rhizoma Corydalis, Radix embeliae laetae, Spica Prunellae, Herba Senecionis Scandentis, conyza blinii, the Rhizoma Anemarrhenae are ground to fine powder respectively, cross 150 mesh sieves, be mixed to get mixture;

(2) step (1) gained mixture is added in deionized water, stir, obtain solution;

(3) hydroxyl methylcellulose is received add in glycerol, stir, obtain solution;

(4) added in step (2) reaction mixture by step (3) reaction mixture, and pour glycerol and xanthan gum into, stirring to leave standstill obtains gel, i.e. B ultrasonic couplant.

Containing plurality of Chinese composition in couplant of the present invention, can effective antibiotic and sterilizing, prevent cross infection, concrete pharmacology analysis is as follows:

Radix Sophorae Flavescentis: bitter, cold.There is heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.

Folium Perillae: property and flavor of peppery and warm, have deliver, cold expelling, the effect of regulating the flow of vital energy and seeking.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen etc.Folium Perillae can suppress aureus growth in vitro.Folium Perillae extractum is 200-1600mg/ml to 6 kinds of mycobiotic agar culture minimum inhibitory concentrations (MIC); Perillaldehyde in extractum plays main bacteriostasis.

Radix Bupleuri: have reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.Radix Bupleuri has bacteriostasis in various degree to staphylococcus aureus, streptococcus pneumoniae, bacillus pyocyaneus and Shu Shi, sonne bacillus in vitro.

Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.Pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating.Herba Artemisiae Scopariae decoct has inhibitory action in various degree to staphylococcus aureus, diphtheria corynebacterium, anthrax bacillus, Bacillus typhi, paratyphoid bacillus A, bacillus pyocyaneus, escherichia coli, bacterium flexneri, dysentery bacterium, meningococcus, bacillus subtilis etc.10% decoct can suppress the growth of Bacillus tuberculosis completely.The concentration of 1: 100 all has inhibitory action to human-like with bacillus tuberculosis bovis.The antibacterial action of capillarisin in vitro tests to chloromycetin has antagonism.Capillin has higher antibacterial action, especially powerful to the effect of dermatosis originality filamentous bacteria, and show as bactericidal action, through long-time more than 100 DEG C high-temperature process, its antimicrbial power does not still lower.The growth and breeding of scarlet hair tinea mattress can also be stoped completely under 0.25 μ g/ml concentration.Escoparone has antiinflammatory action to the edema that Mus carrageenin causes.Acetic acid writhing test and hot plate method all show analgesic activity.

Cortex Moutan: bitter, pungent, is slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.In vitro there is stronger antibacterial action to Staphylococcus albus, bacillus subtilis, escherichia coli, Bacillus typhi etc.To the effect such as dysentery bacterium, Bacillus typhi significantly (in vitro double dilution method), in pH7.0 ~ 7.6, sterilizing power is the strongest for Cortex Moutan.Agar plate trench method etc. also proves to put cold bacillus, escherichia coli in order to Bacillus typhi, dysentery bacterium, pair.The various bacteria such as Bacillus proteus, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, vibrio cholera have inhibitory action in various degree.Paeonol also has inhibitory action to escherichia coli, bacillus subtilis, staphylococcus aureus etc. in vitro.Cortex Moutan immersion also has certain inhibitory action to 10 kinds of dermatophytess such as rust microspore bacterium in vitro.

Cortex Phellodendri: bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.Cortex Phellodendri antibiotic effective ingredient is berberine.In vitro tests is all effective to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium (except Song Nei Shi) etc., nearly unavailable to escherichia coli, Bacillus typhi, there is report to escherichia coli, bacillus pyocyaneus responder.With regard to crude drug, Antibacterial Function of Coptis comparatively Cortex Phellodendri is strong 1 times.To H37Rv, mycobacterium tuberculosis without direct repression, but bacterium number can be made to reduce, or very high concentration (1/100) time present bacteriostasis, but also have report to obtain good result.When making experimental therapy with Cavia porcellus inoculation mycobacterium hominis, curative effect that is oral or injection is all very poor.To the Cavia porcellus of inoculation Mycobacterium bovis, the hydrochloric acid crystal extracted from Cortex Phellodendri does intramuscular injection, has certain curative effect.It is said, Cortex Phellodendri is taken a favorable turn to the clinical symptoms of tuberculosis patient and x-ray inspection, and is better than Rhizoma Coptidis.

Herba Artemisiae Annuae: bitter, acrid, cold.Return liver, gallbladder meridian.Clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.Herba Artemisiae Annuae decocting liquid has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, also has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc.Herba Artemisiae Annuae volatile oil, when 0.25% concentration, has bacteriostasis to all dermatophytosises, when 1% concentration, has bactericidal action to all dermatophytosises.Herba Artemisiae Annuae have the effect of resisiting influenza virus.Sodium artesunate is to golden Fructus Vitis viniferae, shigella flexneri, escherichia coli, micrococcus catarrhalis, and A type and paratyphoid B stalk bacterium all have certain antibacterial action.Sitosterol in Herba Artemisiae Annuae and stigmasterol also have antivirus action.

Flos Chrysanthemi Indici: bitter, pungent, is slightly cold.Return liver, heart channel.Heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, has a headache dizzy.In vitro, Flos Chrysanthemi Indici 1: 80 can delay the pathological changes of the metainfective cell of Orphan virus (the primary adhesion of human embryo kidney (HEK)).Flos Chrysanthemi Indici decoct 1: 320 has inhibitory action to staphylococcus aureus, diphtheria corynebacterium and dysentery bacterium in vitro.

Rhizoma Corydalis: pungent, bitter, temperature.Return liver, spleen channel.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Inhibitory action is in various degree had in vitro to staphylococcus aureus, Staphylococcus albus, streptococcus pneumoniae, streptococcus faecalis, micrococcus scarlatinae, escherichia coli, dysentery bacterium, Bacillus typhi, paratyphoid bacillus A etc.

Radix embeliae laetae: heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding.Main pharyngitis; Gingiva bleeding gingival hemorrhage; Dysentery; Have loose bowels; Furuncle ulcer; Skin pruritus; Swelling and pain of hemorrhoid; Traumatic injury.

Spica Prunellae: pungent, bitter, cold.Return liver, gallbladder meridian.Relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.According to external preliminary test, Spica Prunellae decoct has inhibitory action to dysentery bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus and staphylococcus, streptococcus, and antimicrobial spectrum is also wider.Its water logging agent (1: 4) is in vitro to some common pathogenic dermatophytes also some inhibitory action.Sick to the experimental M of mice, Spica Prunellae can make pulmonary lesion alleviate to some extent.

Herba Senecionis Scandentis: bitter, pungent, cool.Slightly poisonous.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling, liver heat removing and eyesight improving.For wind-fire acute conjunctivitis, furuncle toxic swelling, the diseases such as skin eczema and dysentery stomachache.Stronger antibacterial action is had to will Hayes dysentery bar mattress and staphylococcus aureus, valid density is respectively 1: 1024 and 1: 512, to bacillus such as typhoid fever, paratyphoid fever, paratyphoid fever, dysentery (Fu Shi, Boydii, Song Nei Shi), large intestine, distortion, cured sample anthraxs, and sarcina all has inhibitory action (in vitro doubling dilution).Oral absorption good (rat), the urine of discharge also has certain antibacterial action.

Conyza blinii: bitter, cold.Heat clearing and inflammation relieving, eliminating fire and detoxication.For acute icterohepatitis, toothache, chronic tracheitis, stomatitis, pharyngolaryngitis, tonsillitis, nephritis, malaria; Eye conjunctivitis is controlled in external, otitis media, skin infection, eczema, traumatic hemorrhage.

The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.Rhizoma Anemarrhenae decoct has stronger inhibitory action to staphylococcus, Bacillus typhi on agar plate, also inhibitory action is had to dysentery bacterium, Salmonella paratyphi, escherichia coli, bacillus subtilis, vibrio cholera, in husky Bai Shi culture medium, to some common pathogenic dermatophytosis also some bacteriostasis.Ether extractum and have stronger inhibitory action through the coarse crystallization of acetone treatment gained in general, the H37RV Bacillus tuberculosis subspecies of visiing in Er Shi culture medium in this extractum, the former minimal effective concentration is 1: 64000 (serum-free) or 1: 16000 (increase serum); Latter is 1: 16000 ~ 1: 8000, and the Saponin of forefathers' gained acts on without this.In the treatment to mouse experiment tuberculosis, with containing 2.5% Rhizoma Anemarrhenae powder feedstuff feeding after, have inhibitory action to pulmonary Mycobacterium focus, but the mortality rate of mice and matched group difference little; As brought up to 5%, then the pulmonary tuberculosis index situation of pathological changes (the reflection lungs substantially) can close to different cigarette callosity, but mortality rate comparatively matched group is higher, may be that the toxicity of medicine own is larger former.In the treatment of the experimental M to Cavia porcellus, the Rhizoma Anemarrhenae shows therapeutic effect, and pulmonary lesion comparatively matched group alleviates about 1/2.

The invention has the advantages that:

(1) the Chinese medicine antibacterial composition that B ultrasonic couplant product of the present invention includes is have very strong killing action to gram positive bacteria, negative bacterium in " People's Republic of China's Chinese medicine pharmacopeia ", the pathogenic bacterium on skin and site of injury surface can be killed rapidly, can effectively prevent the pathogenic bacterium on ultrasonic diagnostic probes from using the cross infection caused for postoperative patient;

(2) the Chinese medicine antibacterial composition in B ultrasonic couplant of the present invention makes it have the disinfective action with disinfectant with equivalent efficacy, not only can not damage skin and site of injury simultaneously, but also have agglutinant effect;

(3) the B ultrasonic couplant that the present invention contains Chinese medicine ingredients can form good B ultrasonic sound window in wound surface, can show the subcutaneous each Rotating fields of corrective surgery wound well;

(4) the present invention contains that the B ultrasonic couplant scheme of Chinese medicine ingredients is novel, with low cost, preparation is simple.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described.

Embodiment 1:

A kind of B ultrasonic couplant, according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.0%, Folium Perillae 0.35%, Radix Bupleuri 0.35%, Herba Artemisiae Scopariae 0.2%, Cortex Moutan 0.35%, Cortex Phellodendri 0.5%, Herba Artemisiae Annuae 0.5%, Flos Chrysanthemi Indici 1.0%, Rhizoma Corydalis 0.5%, Radix embeliae laetae 0.5%, Spica Prunellae 0.35%, Herba Senecionis Scandentis 0.6%, conyza blinii 0.6%, the Rhizoma Anemarrhenae 0.6%, glycerol 5%, xanthan gum 5%, sodium carboxymethyl cellulose 3%, glycerol 10%, surplus is deionized water.

Embodiment 2:

A kind of B ultrasonic couplant, according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.25%, Folium Perillae 0.75%, Radix Bupleuri 0.75%, Herba Artemisiae Scopariae 0.4%, Cortex Moutan 0.75%, Cortex Phellodendri 0.8%, Herba Artemisiae Annuae 0.8%, Flos Chrysanthemi Indici 1.25%, Rhizoma Corydalis 0.8%, Radix embeliae laetae 0.8%, Spica Prunellae 0.75%, Herba Senecionis Scandentis 0.9%, conyza blinii 0.9%, the Rhizoma Anemarrhenae 0.9%, glycerol 15%, xanthan gum 8%, sodium carboxymethyl cellulose 6%, glycerol 15%, surplus is deionized water.

Embodiment 3:

A kind of B ultrasonic couplant, according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.1%, Folium Perillae 0.5%, Radix Bupleuri 0.5%, Herba Artemisiae Scopariae 0.3%, Cortex Moutan 0.5%, Cortex Phellodendri 0.6%, Herba Artemisiae Annuae 0.6%, Flos Chrysanthemi Indici 1.1%, Rhizoma Corydalis 0.6%, Radix embeliae laetae 0.6%, Spica Prunellae 0.5%, Herba Senecionis Scandentis 0.8%, conyza blinii 0.8%, the Rhizoma Anemarrhenae 0.8%, glycerol 10%, xanthan gum 7%, sodium carboxymethyl cellulose 5%, glycerol 12%, surplus is deionized water.

Embodiment 4:

Embodiment 1 ~ 3 prepares B ultrasonic couplant according to following steps:

(1) Radix Sophorae Flavescentis, Folium Perillae, Radix Bupleuri, Herba Artemisiae Scopariae, Cortex Moutan, Cortex Phellodendri, Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Rhizoma Corydalis, Radix embeliae laetae, Spica Prunellae, Herba Senecionis Scandentis, conyza blinii, the Rhizoma Anemarrhenae are ground to fine powder respectively, cross 150 mesh sieves, be mixed to get mixture;

(2) step (1) gained mixture is added in deionized water, stir, obtain solution;

(3) hydroxyl methylcellulose is received add in glycerol, stir, obtain solution;

(4) added in step (2) reaction mixture by step (3) reaction mixture, and pour glycerol and xanthan gum into, stirring to leave standstill obtains gel, i.e. B ultrasonic couplant.

Claims (5)

1. a B ultrasonic couplant, it is characterized in that according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.0 ~ 1.25%, Folium Perillae 0.35 ~ 0.75%, Radix Bupleuri 0.35 ~ 0.75%, Herba Artemisiae Scopariae 0.2 ~ 0.4%, Cortex Moutan 0.35 ~ 0.75%, Cortex Phellodendri 0.5 ~ 0.8%, Herba Artemisiae Annuae 0.5 ~ 0.8%, Flos Chrysanthemi Indici 1.0 ~ 1.25%, Rhizoma Corydalis 0.5 ~ 0.8%, Radix embeliae laetae 0.5 ~ 0.8%, Spica Prunellae 0.35 ~ 0.75%, Herba Senecionis Scandentis 0.6 ~ 0.9%, conyza blinii 0.6 ~ 0.9%, the Rhizoma Anemarrhenae 0.6 ~ 0.9%, glycerol 5 ~ 15%, xanthan gum 5 ~ 8%, sodium carboxymethyl cellulose 3 ~ 6%, glycerol 10 ~ 15%, surplus is deionized water.

2. a kind of B ultrasonic couplant according to claim 1, it is characterized in that according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.0%, Folium Perillae 0.35%, Radix Bupleuri 0.35%, Herba Artemisiae Scopariae 0.2%, Cortex Moutan 0.35%, Cortex Phellodendri 0.5%, Herba Artemisiae Annuae 0.5%, Flos Chrysanthemi Indici 1.0%, Rhizoma Corydalis 0.5%, Radix embeliae laetae 0.5%, Spica Prunellae 0.35%, Herba Senecionis Scandentis 0.6%, conyza blinii 0.6%, the Rhizoma Anemarrhenae 0.6%, glycerol 5%, xanthan gum 5%, sodium carboxymethyl cellulose 3%, glycerol 10%, surplus is deionized water.

3. a kind of B ultrasonic couplant according to claim 1, it is characterized in that according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.25%, Folium Perillae 0.75%, Radix Bupleuri 0.75%, Herba Artemisiae Scopariae 0.4%, Cortex Moutan 0.75%, Cortex Phellodendri 0.8%, Herba Artemisiae Annuae 0.8%, Flos Chrysanthemi Indici 1.25%, Rhizoma Corydalis 0.8%, Radix embeliae laetae 0.8%, Spica Prunellae 0.75%, Herba Senecionis Scandentis 0.9%, conyza blinii 0.9%, the Rhizoma Anemarrhenae 0.9%, glycerol 15%, xanthan gum 8%, sodium carboxymethyl cellulose 6%, glycerol 15%, surplus is deionized water.

4. a kind of B ultrasonic couplant according to claim 1, it is characterized in that according to mass percent, formed by following preparation of raw material: Radix Sophorae Flavescentis 1.1%, Folium Perillae 0.5%, Radix Bupleuri 0.5%, Herba Artemisiae Scopariae 0.3%, Cortex Moutan 0.5%, Cortex Phellodendri 0.6%, Herba Artemisiae Annuae 0.6%, Flos Chrysanthemi Indici 1.1%, Rhizoma Corydalis 0.6%, Radix embeliae laetae 0.6%, Spica Prunellae 0.5%, Herba Senecionis Scandentis 0.8%, conyza blinii 0.8%, the Rhizoma Anemarrhenae 0.8%, glycerol 10%, xanthan gum 7%, sodium carboxymethyl cellulose 5%, glycerol 12%, surplus is deionized water.

5. a preparation method for B ultrasonic couplant according to claim 1, is characterized in that carrying out according to following steps:

(1) Radix Sophorae Flavescentis, Folium Perillae, Radix Bupleuri, Herba Artemisiae Scopariae, Cortex Moutan, Cortex Phellodendri, Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Rhizoma Corydalis, Radix embeliae laetae, Spica Prunellae, Herba Senecionis Scandentis, conyza blinii, the Rhizoma Anemarrhenae are ground to fine powder respectively, cross 150 mesh sieves, be mixed to get mixture;

(2) step (1) gained mixture is added in deionized water, stir, obtain solution;

(3) hydroxyl methylcellulose is received add in glycerol, stir, obtain solution;

(4) added in step (2) reaction mixture by step (3) reaction mixture, and pour glycerol and xanthan gum into, stirring to leave standstill obtains gel, i.e. B ultrasonic couplant.