CN107913332A - A kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation method - Google Patents

A kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation method Download PDF

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CN107913332A
CN107913332A CN201710030072.4A CN201710030072A CN107913332A CN 107913332 A CN107913332 A CN 107913332A CN 201710030072 A CN201710030072 A CN 201710030072A CN 107913332 A CN107913332 A CN 107913332A
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western medicine
leaf
disinfectant
combination
chinese
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崔庆军
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/19—Acanthaceae (Acanthus family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/76—Salicaceae (Willow family), e.g. poplar
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The present invention relates to a kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation method, the raw material composition that the combination of Chinese tradiational and Western medicine disinfectant active ingredient is made is：Capitate knotweed herb, Liu Gen, delavay pararuellia herb, forest gray gum leaf, emblic leafflower leaf, cup chrysanthemum, japanese dock leaf, Juniperus formosana Hayata, water shield, osbeckia chinensis, cannalike dona rhizome, beggar-ticks, indigo naturalis, triclosan, decontamination；The present invention is to according to theory of traditional Chinese medical science, Chinese medicine is reasonably selected and compatibility, and combine western medicine composition, disinfectant is made, it is administered in medical clinical laboratory room, have the advantages that sterilizing ability strong, work fast, stability it is strong, it is cheap on the basis of play drug effect comprehensively, strengthen disinfection effect of the present invention；And combine and the dosage in material composition is defined and controlled so that mutual cooperative effect occurs between each material composition, enhances the drug effect of the present invention, solves the deficiency of existing western medicine therapy and tcm therapy.

Description

A kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation method
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation side Method.
Background technology
Medical test is the subject that medical diagnosis is carried out with modern physics chemical method, means, and main research is such as What by laboratory technique, medical instruments and equipment be clinical diagnosis, treats and provides foundation.By systematic learning, we it will be appreciated that How surveyor blood group, determining a people, whether anaemia, liver function normal etc..The subject requires to use various photoelectricity Instrument and chemical reagent complete experimental analysis, so laying particular stress on natural sciences, it is desirable to have preferable biology, chemical fundamentals.
During the work time, often in contact with the sample with bacterium, virus in control laboratory, therefore, it is very easy to be infected with one A little bacterium, viruses, and sterilizing medicine human body wound multipair greatly and skin used in control laboratory are irritant at present, have It can even cause allergic reaction, or even the skin diseases such as dermatitis and eczema can be triggered.
In recent years, by, Western medicine is applied to the research that sterilizes in control laboratory and starts the concern and attention for being subject to domestic scholars.
The content of the invention
The present invention provides a kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation method；The present invention is to the medical knowledge in By, Chinese medicine is reasonably selected and compatibility, and western medicine composition is combined, disinfectant is made, is administered in clinical laboratory room, is having Have the advantages that sterilizing ability strong, work fast, stability it is strong, it is cheap on the basis of play drug effect comprehensively, strengthen this hair Bright disinfection effect；And combine and the dosage in material composition is defined and controlled so that sent out between each material composition Raw mutual cooperative effect, enhances the drug effect of the present invention, solves the deficiency of existing western medicine therapy and tcm therapy.
To achieve the above object, technical scheme is implemented as follows：
A kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant, is made the combination of Chinese tradiational and Western medicine disinfectant active ingredient
Including traditional Chinese medicinal components and western medicine component, the traditional Chinese medicinal components are formulated by the raw material of following weight number：Capitate knotweed herb 49- 61g, willow root 44-57g, delavay pararuellia herb 44-57g, forest gray gum leaf 39-53g, emblic leafflower leaf 36-49g, cup chrysanthemum 30-42g, japanese dock leaf 30- 42g, Juniperus formosana Hayata 24-36g, water shield 18-30g, osbeckia chinensis 14-26g, cannalike dona rhizome 14-26g, beggar-ticks 9-21g, indigo naturalis 9-21g； The western medicine component is formulated by the raw material of following weight number：Triclosan 5-10mg, decontamination 5-10mg.
The combination of Chinese tradiational and Western medicine disinfectant active ingredient, which is made, includes traditional Chinese medicinal components and western medicine component, the traditional Chinese medicinal components by The raw material of following weight number is formulated：Capitate knotweed herb 58g, willow root 54g, delavay pararuellia herb 54g, forest gray gum leaf 49g, emblic leafflower leaf 45g, cup Chrysanthemum 39g, japanese dock leaf 39g, Juniperus formosana Hayata 33g, water shield 27g, osbeckia chinensis 23g, cannalike dona rhizome 23g, beggar-ticks 18g, indigo naturalis 18g；It is described Western medicine component is formulated by the raw material of following weight number：Triclosan 8mg, decontamination 8mg.
The combination of Chinese tradiational and Western medicine disinfectant active ingredient, which is made, includes traditional Chinese medicinal components and western medicine component, the traditional Chinese medicinal components by The raw material of following weight number is formulated：Capitate knotweed herb 55g, willow root 51g, delavay pararuellia herb 51g, forest gray gum leaf 45g, emblic leafflower leaf 42g, cup Chrysanthemum 36g, japanese dock leaf 36g, Juniperus formosana Hayata 30g, water shield 24g, osbeckia chinensis 20g, cannalike dona rhizome 20g, beggar-ticks 15g, indigo naturalis 15g；It is described Western medicine component is formulated by the raw material of following weight number：Triclosan 7mg, decontamination 7mg.
The combination of Chinese tradiational and Western medicine disinfectant active ingredient, which is made, includes traditional Chinese medicinal components and western medicine component, the traditional Chinese medicinal components by The raw material of following weight number is formulated：Capitate knotweed herb 52g, willow root 48g, delavay pararuellia herb 48g, forest gray gum leaf 41g, emblic leafflower leaf 39g, cup Chrysanthemum 33g, japanese dock leaf 33g, Juniperus formosana Hayata 27g, water shield 21g, osbeckia chinensis 17g, cannalike dona rhizome 17g, beggar-ticks 12g, indigo naturalis 12g；It is described Western medicine component is formulated by the raw material of following weight number：Triclosan 6mg, decontamination 6mg.
A kind of clinical laboratory preparation method of combination of Chinese tradiational and Western medicine disinfectant, comprises the following steps that：
(1) capitate knotweed herb, forest gray gum leaf, emblic leafflower leaf, japanese dock leaf, water shield, cannalike dona rhizome and beggar-ticks are entered into juice of squeezing out in juice extractor, Impurity is filtered, stays juice, it is spare；
(2) Liu Gen is added into 10 times of amount volumetric concentration 70% ethanol extractions three times, every time 3 it is small when, filtration, merging filtrate, was placed Night, recycle ethanol and be concentrated into 60 DEG C of relative densities be 1.12-1.15 dope it is spare；
(3) by delavay pararuellia herb, cup chrysanthemum and osbeckia chinensis microwave drying, grind, cross 160 targeted fine powders, it is spare；
(4) Juniperus formosana Hayata and indigo naturalis are put into container, add 10 times amount distilled water immersions 4 it is small when after, heating boil 4 it is small when, carry Take；Second add 8 times of amount distilled water heating boil 3 it is small when, extraction；It is small that 6 times of amount distilled water heating of third time addition boil 2 When, extraction；Merge gained extracting solution three times, filtration, it is spare to obtain filtrate；
(5) triclosan is ground, crosses 260 targeted fine powders, it is spare；
(6) decontamination is dissolved in 2 times of amount pure water, stirs evenly, obtain solution for standby；
(7) by above-mentioned steps（1）-（6）Made juice, dope, fine powder, filtrate and solution mixing, and add 8-10 times and measure Distilled water, after stirring and dissolving is uniform, heating boil 0.5 it is small when, to less than 60 DEG C, stand 1 it is small when, filter, obtain filtrate, will filter Liquid is filling to be sealed up for safekeeping, 121 DEG C of pressure sterilizings 30 minutes, and 500ml/ bottles of thimerosal is made, packs, and is the clinical laboratory With combination of Chinese tradiational and Western medicine disinfectant.
The pharmacological property of Chinese medicine used in the present invention is as follows：
Capitate knotweed herb：It is bitter, pungent, it is cool in nature.Clearing heat and promoting diuresis, promoting blood circulation and stopping pain.Main dysentery, pyelonephritis, cystitis, lithangiuria, wind Wet pain, traumatic injury, mumps, sore, eczema.《Guangxi Chinese herbal medicine》Carry：" detoxicating, relieving inflammation.Dysentery is controlled, skin ulcer is unknown swollen Poison.”
Liu Gen：Bitter, it is cold in nature.Promoting diuresis for stranguria, wind-dispelling is except pain, purging intense heat and detonicating.Main stranguria, gonorrhoea, oedema, jaundice, dysentery, in vain Band, rheumatalgia pain, impetigo, has a toothache, scald, acute mastitis.《Vegetation is just square》Carry：" dispelling wind and eliminating dampness, treats hot dysentery, collapses, band, four limbs are arrested Contraction, muscle pain, Tang Huo, toothache.”
Delavay pararuellia herb：It is mildly bitter flavor, pungent, it is cool in nature.It is clearing heat and detoxicating, eliminating stasis to subdue swelling.Main cough with lung heat, abscess of throat, mumps, scrofula, carbuncle Swollen sore, injury and bone fracture, trauma infection contamination.《Yunnan Chinese herbal medicine choosing》Carry：" anti-inflammatory is drawn out pus by applying a plaster to the affected part, myogenic, dissipates stasis of blood life newly, desinsection.Control acute Suppurative tonsillitis, pneumonia, sore abscess, the raw maggot of wound infection.”
Forest gray gum leaf：Acrid flavour, slight bitter, it is mild-natured；Return lung, stomach, large intestine channel.Facilitaing lung is delivered, vital energy regualting and blood circulation-promoting, and detoxify desinsection.Main flu Fever, cough and asthma phlegm are coughed, abdominal distention, rush down dysentery, leptospirosis, traumatic injury, sore, erysipelas, acute mastitis, scabies, and tinea is itched. 《Luchuan book on Chinese herbal medicine》Carry：" cure cold, cough, inflatable abdominal pain, diarrhea diarrhea, traumatic injury；Carbuncle, ulcer are controlled outside, and can be rinsed Disinfectant." modern medicine study confirmation, 50% gray gum decocting liquid is to box staphylococcus aureus（Concentration is 1：1280）, the double balls of pneumonia Bacterium（1：10240）, beta streptococcus（1：2560）There is stronger bacteriostasis.
Emblic leafflower leaf：Sweet in flavor, slight bitter, it is cool in nature；The thoughts of returning home, liver, large intestine channel.It is clearing heat and detoxicating, it is inducing diuresis and reducing edema.Main aphtha, furunculosis are wet Rash, dermatitis, oedema, hypertension, venomous snake bite, traumatic injury.《Luchuan book on Chinese herbal medicine》Carry：" corruption is gone in sterilization.It is rotten to control mouth, the skin diseases of the scrota and Infantile malnutrition due to digestive disturbances or intestinalparasites, malignant boil, leakage, hemorrhoid.”
Cup chrysanthemum：Bitter, it is cool in nature.Clearing heat and detoxicating, anti-inflammation hemostasia, dehumidify diuresis, desinsection.Cure mainly acute gastroenteritis, heatstroke, bladder Inflammation, urethritis, sphagitis, stomatitis, spits blood, bleeding from five sense organs or subcutaneous tissue.
Japanese dock leaf：It is sweet in flavor, it is cold in nature.Cooling blood and hemostasis, defaecation, removing toxicity for detumescence, desinsection are antipruritic.Main hematochezia, constipation, children Infantile malnutrition due to digestive disturbances or intestinalparasites ulcerative carbuncle pyogenic infections, mange.《Guizhou prescription collection among the people》Carry：" external application, which disappears, hinders swollen sore.”
Juniperus formosana Hayata：Bitter, it is cold in nature.Clearing heat and detoxicating, eliminating dampness is antipruritic.Djumah rash high fever, eczema, tinea sore.Jinhua《Common medium-height grass prescription Square proved recipe a collection of selected materials》Carry：" control skin tinea, continuous low fever.”
Water shield：It is sweet in flavor, it is cold in nature.It is clearing heat and detoxicating, preventing or arresting vomiting.High blood pressure is cured mainly, rush down dysentery, has a stomachache, and vomiting, gastric disorder causing nausea, ulcer malignant boil swells, heat Furuncle.
Osbeckia chinensis：It is acrid flavour, light, it is mild-natured；Return lung, spleen, liver, large intestine channel.Resolving sputum dampness removing, dissolving stasis and hemostasis, removing toxicity for detumescence.Main cough Cough, asthma, dysentery, diarrhea, spits blood, and spitting of blood, has blood in stool, Amenorrhea, infantile malnutrition due to digestive disturbances or intestinalparasites, treating rheumatic ostealgia, traumatic injury.《Nanning City's medicine will》 Carry：" stasis eliminatings life is new, analgesic convergence.Interior external hemorrhage is controlled, infantile malnutrition due to digestive disturbances or intestinalparasites, noma, has a toothache, cough.”
Cannalike dona rhizome：It is lightly seasoned, it is cool in nature；It is distributed in lung channel.It is clearing heat and detoxicating, relieving cough and relieving asthma.Main cold, fever, cough, children's measles merge lung Inflammation, asthma, pulmonary tuberculosis.
Beggar-ticks：Bitter, cold nature.It is clearing heat and detoxicating, dispelling wind and eliminating dampness, activating blood circulation and reducing swelling.Cure mainly malaria, diarrhea, dysentery, liver Inflammation, acute nephritis, stomachache, dysphagic, acute appendicitis, abscess of throat, traumatic injury, snakebite and bugbite.Modern medicine study confirmation, beggar-ticks Ethanol extract have bacteriostasis to gram-positive bacterium in vitro, flower, stem also have bacteriostasis to staphylococcus aureus.
Indigo naturalis：Taste is salty, cold in nature；Return liver, lung, stomach.It is clearing heat and detoxicating, cooling blood and hemostasis, clearing liver-fire.Main warm disease heat toxin spot Rash, blood-head are spitted blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, the hot frightened epilepsy of liver, liver-fire attacking lung cough, abscess of throat, erysipelas, Zha, sore swells, snakebite and bugbite. 《Kaibao Bencao》Carry：" all medicine poison of principal solution, infantile pyretic diseases, fever of fainting from fear, pestilent headache fever and chills, pan-fried water, which is ground, takes it.Also rub and apply heat Sore, dislike the poison such as swollen, metal-inflicted wound, lower blood, snake dog.”
Compared with prior art, the present invention have the advantages that：
The present invention combines western medicine composition to according to theory of traditional Chinese medical science, being reasonably selected to Chinese medicine and compatibility, and disinfection is made Agent, is administered in clinical laboratory room, has the advantages that strong sterilizing ability, work fast, the basis that stability is strong, cheap It is upper to play drug effect comprehensively, strengthen disinfection effect of the present invention；And combine and the dosage in material composition is defined and controlled System so that mutual cooperative effect occurs between each material composition, enhance the present invention drug effect, solve existing western medicine therapy and The deficiency of tcm therapy.
Embodiment
The present invention is further elaborated with reference to specific embodiment.
Embodiment 1
The raw material of combination of Chinese tradiational and Western medicine disinfectant active ingredient of the present invention forms and weight is：Capitate knotweed herb 59g, willow root 55g, delavay pararuellia herb 55g, forest gray gum leaf 51g, emblic leafflower leaf 47g, cup chrysanthemum 40g, japanese dock leaf 40g, Juniperus formosana Hayata 34g, water shield 28g, osbeckia chinensis 24g, the leaf of bamboo Any of several broadleaf plants 24g, beggar-ticks 20g, indigo naturalis 20g, triclosan 9mg, decontamination 9mg.
The preparation method of combination of Chinese tradiational and Western medicine disinfectant of the present invention, comprises the following steps that：
(1) capitate knotweed herb, forest gray gum leaf, emblic leafflower leaf, japanese dock leaf, water shield, cannalike dona rhizome and beggar-ticks are entered into juice of squeezing out in juice extractor, Impurity is filtered, stays juice, it is spare；
(2) Liu Gen is added into 10 times of amount volumetric concentration 70% ethanol extractions three times, every time 3 it is small when, filtration, merging filtrate, was placed Night, recycle ethanol and be concentrated into 60 DEG C of relative densities be 1.12-1.15 dope it is spare；
(3) by delavay pararuellia herb, cup chrysanthemum and osbeckia chinensis microwave drying, grind, cross 160 targeted fine powders, it is spare；
(4) Juniperus formosana Hayata and indigo naturalis are put into container, add 10 times amount distilled water immersions 4 it is small when after, heating boil 4 it is small when, carry Take；Second add 8 times of amount distilled water heating boil 3 it is small when, extraction；It is small that 6 times of amount distilled water heating of third time addition boil 2 When, extraction；Merge gained extracting solution three times, filtration, it is spare to obtain filtrate；
(5) triclosan is ground, crosses 260 targeted fine powders, it is spare；
(6) decontamination is dissolved in 2 times of amount pure water, stirs evenly, obtain solution for standby；
(7) by above-mentioned steps（1）-（6）Made juice, dope, fine powder, filtrate and solution mixing, and add 8-10 times and measure Distilled water, after stirring and dissolving is uniform, heating boil 0.5 it is small when, to less than 60 DEG C, stand 1 it is small when, filter, obtain filtrate, will filter Liquid is filling to be sealed up for safekeeping, and 121 DEG C of pressure sterilizings 30 minutes, are made
500ml/ bottles of thimerosal, packs, and is clinical laboratory's combination of Chinese tradiational and Western medicine disinfectant.
Embodiment 2
The raw material of combination of Chinese tradiational and Western medicine disinfectant active ingredient of the present invention forms and weight is：Capitate knotweed herb 58g, willow root 54g, delavay pararuellia herb 54g, forest gray gum leaf 49g, emblic leafflower leaf 45g, cup chrysanthemum 39g, japanese dock leaf 39g, Juniperus formosana Hayata 33g, water shield 27g, osbeckia chinensis 23g, the leaf of bamboo Any of several broadleaf plants 23g, beggar-ticks 18g, indigo naturalis 18g, triclosan 8mg, decontamination 8mg.
The present embodiment combination of Chinese tradiational and Western medicine disinfectant preparation method processing step and usage and dosage are same as Example 1.
Embodiment 3
The raw material of combination of Chinese tradiational and Western medicine disinfectant active ingredient of the present invention forms and weight is：Capitate knotweed herb 55g, willow root 51g, delavay pararuellia herb 51g, forest gray gum leaf 45g, emblic leafflower leaf 42g, cup chrysanthemum 36g, japanese dock leaf 36g, Juniperus formosana Hayata 30g, water shield 24g, osbeckia chinensis 20g, the leaf of bamboo Any of several broadleaf plants 20g, beggar-ticks 15g, indigo naturalis 15g, triclosan 7mg, decontamination 7mg.
The present embodiment combination of Chinese tradiational and Western medicine disinfectant preparation method processing step and usage and dosage are same as Example 1.
Embodiment 4
The raw material of combination of Chinese tradiational and Western medicine disinfectant active ingredient of the present invention forms and weight is：Capitate knotweed herb 52g, willow root 48g, delavay pararuellia herb 48g, forest gray gum leaf 41g, emblic leafflower leaf 39g, cup chrysanthemum 33g, japanese dock leaf 33g, Juniperus formosana Hayata 27g, water shield 21g, osbeckia chinensis 17g, the leaf of bamboo Any of several broadleaf plants 17g, beggar-ticks 12g, indigo naturalis 12g, triclosan 6mg, decontamination 6mg.
The present embodiment combination of Chinese tradiational and Western medicine disinfectant preparation method processing step and usage and dosage are same as Example 1.
Experimental section
The effect of below present invention being selected to be tested accordingly, further proving the present invention.
First, soluble test
1st, take combination of Chinese tradiational and Western medicine disinfectant 10ml of the present invention to be put into container, then add distilled water, after stirring evenly, filtering.
2nd, after the completion of filtering, filter paper is observed, is remained on filter paper without obvious.
3rd, conclusion：Combination of Chinese tradiational and Western medicine disinfectant of the present invention is highly soluble in water, is occurred using rear noresidue impurity.
2nd, toxicity test
1st, acute oral toxicity test：The healthy Kunming kind level-one mouse 20 of weight 18-20g is chosen, half male and half female, this is sent out The bright oral gastric infusion of combination of Chinese tradiational and Western medicine disinfectant, administration observation 15 days, records the various performances of mouse and death condition, meter daily Calculate LD. values.
2nd, cumulative toxicity test：The healthy Kunming kind level-one rat 20 of weight 180-200g is chosen, half male and half female, incite somebody to action this The oral gastric infusion of invention combination of Chinese tradiational and Western medicine disinfectant, the LD. values that dosage is drawn according to acute oral toxicity test, 1-4 My god, 0.1LD. is administered every time, every four hours later incremental 1.5 multiple doses, are administered 30 days, and every four hours weigh once, calculate Cumulative coefficient.
3rd, result：No abnormality seen reacts after acute oral toxicity test mouse perfusion, does not occur death, it is carried out accordingly After dissection, tissue or internal organ have no substantially there is obvious abnormal change.
After cumulative toxicity test is administered 20 days, male and female mouse occurs without death condition, mouse cumulative coefficient 5, the weak storage in position Product toxicity.
3rd, Ocular irritation is tested
1st, healthy white rabbit 10, weight 2.5-3.0kg is selected, by combination of Chinese tradiational and Western medicine disinfectant stock solution 0.1ml drops of the present invention It is intracapsular to enter rabbit conjunctiva of left eye, uses normal saline flushing after passive closure 4s, right eye instills physiological saline as control.
2nd, observe rabbit 6 it is small when, 24 it is small when, 48 it is small when and 72 it is small when in eyes localized variation.
3rd, result：Rabbit contamination group cornea and iris are normal, and conjunctiva has no oedema, there is slight hyperemia, conjunctiva stimulus index For 1, by acute ocular stimulus intensity analytic intensity grade scale, belong to nonirritant.
4th, skin irritation test
1st, select healthy white rabbit 10, weight 2.5-3.0kg, by the depilation of family's rabbit back backbone both sides be respectively 3.0cm × 3.0cm, does not damage epidermis, 24 it is small when after, the stoste of 0.2ml combination of Chinese tradiational and Western medicine disinfectants of the present invention is uniformly applied to exposed skin The left side of skin, right side as control does not smear, 4 it is small when after, skin wiping is clean, observe dermoreaction, carry out stimulation scoring.
2nd, result：Rabbit baring skin there are no erythema and oedema reaction, and skin wound repair integrated value is 0, control sides Skin no abnormality seen, by skin wound repair standards of grading, reaction integral mean value is 0, in the present invention
Doctor trained in Western medicine combination disinfectant is to no skin irritation.
5th, stability test
Combination of Chinese tradiational and Western medicine disinfectant 50ml of the present invention is taken, after being placed 90 days under the conditions of 37 DEG C, for being killed to Escherichia coli Compare no significant difference before bacterium, its killing effect and storage.
6th, bacteriostatic test
Bacteriostatic experiment is carried out to combination of Chinese tradiational and Western medicine disinfectant of the present invention below：
1st, experimental strain：
Select the representative strain in laboratory, Escherichia coli and Pseudomonas aeruginosa.
2nd, bacterium culture medium：
Nutrient agar and nutrient broth medium.
3rd, experiment classification：
Bacteriostatic experiment divides experimental group and control group, and experimental group selects combination of Chinese tradiational and Western medicine disinfectant of the present invention, and control group selects time chlorine Acid.
4th, specific experiment step：
（1）The preparation of bacterium solution：Above two strain is inoculated on two agar mediums respectively, it is small that 24 are cultivated at 37 DEG C When, picking colonies typical is inoculated in two fresh nutrient broth mediums respectively from above-mentioned agar medium respectively, together At a temperature of, it is spare when culture 20 is small；
（2）Each 55ml of combination of Chinese tradiational and Western medicine disinfectant and hypochlorous acid of the present invention is taken, is respectively placed in cut-back tank, it is diluted respectively 25 times, above two dilution liquor is split in two containers respectively, is placed under aseptic condition, it is spare；
（3）By above-mentioned steps（1）Through nutrition broth cultivation support 24 it is small when experimental strain dilute 50 respectively with sterile nutrient broth Times, every kind of strain is sub-packed in two culture dishes, marks control group and experimental group respectively；
（4）By above-mentioned steps（2）The dilute solution of two parts of combination of Chinese tradiational and Western medicine disinfectants of the present invention of gained is respectively dropped into experimental group Culture dish, two parts of hypochlorous acid dilute solutions are respectively dropped into control group culture dish.
5th, experimental observation measures：
Above-mentioned experiment is observed, two groups of strains is observed and measures strain revolution mark concrete outcome.
6th, after observation measurement, above-mentioned culture dish is placed in stand two days under aseptic condition, liquid to be sterilized is waved completely After hair, Follow-up observation finds that control group bacterium colony continues to breed, and experimental group bacterium colony is unchanged.
7th, experimental result：
The sterilizing ability of experimental group combination of Chinese tradiational and Western medicine disinfectant of the present invention is much larger than the sterilizing ability of control group thimerosal, and energy Enough suppress all kinds of strains to continue to breed.

Claims (5)

  1. A kind of 1. clinical laboratory combination of Chinese tradiational and Western medicine disinfectant, it is characterised in that：Be made the combination of Chinese tradiational and Western medicine disinfectant effectively into Dividing includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are formulated by the raw material of following weight number：Capitate knotweed herb 49-61g, Willow root 44-57g, delavay pararuellia herb 44-57g, forest gray gum leaf 39-53g, emblic leafflower leaf 36-49g, cup chrysanthemum 30-42g, japanese dock leaf 30-42g, Juniperus formosana Hayata 24-36g, water shield 18-30g, osbeckia chinensis 14-26g, cannalike dona rhizome 14-26g, beggar-ticks 9-21g, indigo naturalis 9-21g；It is described Western medicine component is formulated by the raw material of following weight number：Triclosan 5-10mg, decontamination 5-10mg.
  2. A kind of 2. clinical laboratory combination of Chinese tradiational and Western medicine disinfectant according to claim 1, it is characterised in that：The Chinese and Western is made Doctor, which combines disinfectant active ingredient, includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are prepared by the raw material of following weight number Form：Capitate knotweed herb 58g, willow root 54g, delavay pararuellia herb 54g, forest gray gum leaf 49g, emblic leafflower leaf 45g, cup chrysanthemum 39g, japanese dock leaf 39g, mountain thorn Cypress 33g, water shield 27g, osbeckia chinensis 23g, cannalike dona rhizome 23g, beggar-ticks 18g, indigo naturalis 18g；The western medicine component is by following weight number Raw material be formulated：Triclosan 8mg, decontamination 8mg.
  3. A kind of 3. clinical laboratory combination of Chinese tradiational and Western medicine disinfectant according to claim 1, it is characterised in that：The Chinese and Western is made Doctor, which combines disinfectant active ingredient, includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are prepared by the raw material of following weight number Form：Capitate knotweed herb 55g, willow root 51g, delavay pararuellia herb 51g, forest gray gum leaf 45g, emblic leafflower leaf 42g, cup chrysanthemum 36g, japanese dock leaf 36g, mountain thorn Cypress 30g, water shield 24g, osbeckia chinensis 20g, cannalike dona rhizome 20g, beggar-ticks 15g, indigo naturalis 15g；The western medicine component is by following weight number Raw material be formulated：Triclosan 7mg, decontamination 7mg.
  4. A kind of 4. clinical laboratory combination of Chinese tradiational and Western medicine disinfectant according to claim 1, it is characterised in that：The Chinese and Western is made Doctor, which combines disinfectant active ingredient, includes traditional Chinese medicinal components and western medicine component, and the traditional Chinese medicinal components are prepared by the raw material of following weight number Form：Capitate knotweed herb 52g, willow root 48g, delavay pararuellia herb 48g, forest gray gum leaf 41g, emblic leafflower leaf 39g, cup chrysanthemum 33g, japanese dock leaf 33g, mountain thorn Cypress 27g, water shield 21g, osbeckia chinensis 17g, cannalike dona rhizome 17g, beggar-ticks 12g, indigo naturalis 12g；The western medicine component is by following weight number Raw material be formulated：Triclosan 6mg, decontamination 6mg.
  5. 5. a kind of preparation method that combination of Chinese tradiational and Western medicine disinfectant is used such as the disinfection of claim 1-4 any one of them clinical laboratory, its It is characterized in that：Comprise the following steps：
    (1) capitate knotweed herb, forest gray gum leaf, emblic leafflower leaf, japanese dock leaf, water shield, cannalike dona rhizome and beggar-ticks are entered into juice of squeezing out in juice extractor, Impurity is filtered, stays juice, it is spare；
    (2) Liu Gen is added into 10 times of amount volumetric concentration 70% ethanol extractions three times, every time 3 it is small when, filtration, merging filtrate, was placed Night, recycle ethanol and be concentrated into 60 DEG C of relative densities be 1.12-1.15 dope it is spare；
    (3) by delavay pararuellia herb, cup chrysanthemum and osbeckia chinensis microwave drying, grind, cross 160 targeted fine powders, it is spare；
    (4) Juniperus formosana Hayata and indigo naturalis are put into container, add 10 times amount distilled water immersions 4 it is small when after, heating boil 4 it is small when, carry Take；Second add 8 times of amount distilled water heating boil 3 it is small when, extraction；It is small that 6 times of amount distilled water heating of third time addition boil 2 When, extraction；Merge gained extracting solution three times, filtration, it is spare to obtain filtrate；
    (5) triclosan is ground, crosses 260 targeted fine powders, it is spare；
    (6) decontamination is dissolved in 2 times of amount pure water, stirs evenly, obtain solution for standby；
    (7) by above-mentioned steps（1）-（6）Made juice, dope, fine powder, filtrate and solution mixing, and add 8-10 times and measure Distilled water, after stirring and dissolving is uniform, heating boil 0.5 it is small when, to less than 60 DEG C, stand 1 it is small when, filter, obtain filtrate, will filter Liquid is filling to be sealed up for safekeeping, 121 DEG C of pressure sterilizings 30 minutes, and 500ml/ bottles of thimerosal is made, packs, and is the clinical laboratory With combination of Chinese tradiational and Western medicine disinfectant.
CN201710030072.4A 2017-01-17 2017-01-17 A kind of clinical laboratory combination of Chinese tradiational and Western medicine disinfectant and preparation method Withdrawn CN107913332A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109090164A (en) * 2018-07-11 2018-12-28 李玉茹 A kind of composite disinfectant and preparation method thereof of hospital's external application

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109090164A (en) * 2018-07-11 2018-12-28 李玉茹 A kind of composite disinfectant and preparation method thereof of hospital's external application

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