CN103329949B - Disinfectant for clinical laboratory and preparation method of disinfectant - Google Patents
Disinfectant for clinical laboratory and preparation method of disinfectant Download PDFInfo
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- CN103329949B CN103329949B CN201310317749.4A CN201310317749A CN103329949B CN 103329949 B CN103329949 B CN 103329949B CN 201310317749 A CN201310317749 A CN 201310317749A CN 103329949 B CN103329949 B CN 103329949B
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Abstract
The invention discloses disinfectant for a clinical laboratory and a preparation method of the disinfectant, and relates to the field of traditional Chinese medicine. The active ingredients of the disinfectant consist of the following ingredients including angelica, eucalyptus globulus, lalang grass rhizome, mangnolia officinalis, resina toxicodendri, hemerocallis fulva, solanum mauritianum, fructus chebulae, Chinese torreya, Euphorbia fischeriana steud, juniper berry, golden larch bark, fructus forsythiae, short-tube lycoris, purslane and dark plum. The disinfectant for the clinical laboratory adopts natural ingredients, is a pure traditional Chinese medicine preparation, is prepared by adopting the modern advanced medicine pharmacy technology, and has the advantages of high disinfection capability, high acting speed, high stability, no toxicity, no corrosion, small irritation, easy water solubility, low price, easy acquisition and the like, in addition, the disinfectant is safe and harmless on people and animals, the environment pollution degree is low, and the disinfectant belongs to ideal broad-spectrum disinfectant.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to thimerosal and preparation method for a kind of clinical laboratory.
Background technology
Clinical laboratory is the place of testing for sample in hospital, and wherein sample comprises blood, urine sample, excrement sample etc.In the course of the work, because medical worker often contacts these samples, therefore, be easy to be infected with some bacteriums.Therefore, can to kill the thimerosal of bacterium be work highly significant in searching.
The features such as desirable thimerosal should possess sterilization wide spectrum, sterilizing ability is strong, speed of action is fast, good stability, toxicity is low, corrosivity is little, excitant is little, soluble in water, safe and cheap and easy to get to humans and animals, environmental pollution degree is low.For this reason, research and develop a kind of desirable thimerosal, significant to clinical laboratory's sterilization.
Summary of the invention
The invention provides thimerosal and preparation method for a kind of clinical laboratory, clinical laboratory of the present invention takes from natural component with thimerosal, for pure Chinese medicinal preparation, and adopt modern advanced medical pharmaceutical technology to make, have that sterilizing ability is strong, speed of action is fast, good stability, the advantage such as be easy to get that avirulence, non-corrosiveness, excitant be little, soluble in water, cheap, and safe and harmless to humans and animals, environmental pollution degree is low, is a kind of desirable broad-spectrum disinfectant liquid.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Clinical laboratory's thimerosal, raw material composition and the parts by weight of making described thimerosal active ingredient are:
Raw material composition and the parts by weight of making described thimerosal active ingredient are:
Raw material composition and the parts by weight of making described thimerosal active ingredient are:
Raw material composition and the parts by weight of making described thimerosal active ingredient are:
A preparation method for thimerosal for clinical laboratory, comprises following processing step:
(1) Radix Angelicae Sinensis, blue gum, cogongrass rhizome, dried lacquer, tawny daylily, Chinese torreyanut, the capsule of weeping forsythia and short-tube lycoris are put into container, add 5 times of water gagings, soak after 2-3 hour, decoct continuously three times, decoct three hours at every turn, after each decoction, extract decoction liquor, finally merge the decoction liquor of extracting for three times, filter, obtain filtrate, standby;
(2) by bark of official magnolia chopping, put into pot, add 0.5 times of amount yellow rice wine, intense fire is fried to micro-Huang, takes out, and dries, and grinds into powder, crosses 200 order fine powders, standby;
(3) myrobalan is smashed to pieces, put into container, add the ethanol of 0.5 times of amount, soak after 2～3 hours, filter, get filtrate, standby;
(4) wild cigarette, euphorbiae fischerianae, needle juniper fruit and kitchen garden are cleaned, put into container, smash to pieces, stay juice standby;
(5) get Golden Larch Bark and put into mortar, grind into powder, cross 120 order fine powders, standby;
(6) get dark plum and clean, with vinegar, mix thoroughly, slow fire is vexed to be moistened while being sucked to vinegar, puts suitable container interior airtight, with steam heated 2-4 hour, takes out and is dried, and grinds into powder, crosses 200 order fine powders, standby;
(7) filtrate of gained in step (1)-(6), fine powder and juice are mixed, after mediation, utilize modern advanced pharmacy science and technology, make thimerosal, obtain described clinical laboratory's thimerosal.
The property of medicine of the present invention's Chinese medicine used is as follows:
Radix Angelicae Sinensis: warm in nature, taste is sweet, pungent; Return liver, the heart, the spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, relaxes bowel, for sallow, the dizzy palpitaition of the deficiency of blood, asthenia cold abdominalgia, arthralgia due to wind-dampness, injury from falling down, ulcer sores.According to < < book on Chinese herbal medicine, positive > > carries: " its taste is sweet and weigh; therefore specially can enrich blood; its gas is light and pungent, thus again can promoting circulation of blood, can nourish blood; tonifying Qi production of sperm; five viscera settling, strong body, beneficial mind; all tangible deficient diseases, without unsuitable." modern medicine study confirms, antibacterial, antiinflammation that Radix Angelicae Sinensis has, Radix Angelicae Sinensis hot water extract has obvious inhibitory action during to the acute attack of chronic rheumatoid arthritis.
Blue gum: micro-pungent, the micro-hardship of taste, property is flat.Dispelling wind is antipyretic, and inhibiting bacteria and diminishing inflammation is anticorrosion antipruritic.Be used for preventing influenza, meningococal meningitis, control the infection of the upper respiratory tract, sphagitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filariosis; Burn and scald is controlled in external application, cellulitis, mastitis, furuncle, erysipelas, paddy-field dermatitis, skin eczema, the ringworm of the foot, skin degerming.Modern medicine study confirms, the several functions such as eucalyptus oil has sterilization, sterilizes, eliminates the phlegm, step-down, and the derived essential oil of blue gum has antioxidation, and has anti-inflammatory, digestion promoting function, rheumatic arthritis, gastritis and the gynaecological imflammation etc. of being used for the treatment of among the people.
Cogongrass rhizome: cool blood, hemostasis, heat-clearing, diuresis.Main internal lesion caused by overexertion void is thin, and tonifying middle-Jiao and Qi, except hemostasis, blood close fever and chills.Cogongrass rhizome has obvious inhibitory action to Fu Shi and sonne bacillus.
The bark of official magnolia: bitter, pungent, warm in nature.Enter spleen, stomach, lung, large intestine channel.Modern medicine study confirmation, the bark of official magnolia has stronger antibacterial action to shigella dysenteriae, Escherichia coli, typhoid bacillus, stronger than the coptis, the root of large-flowered skullcap to the antibacterial action of staphylococcus aureus.
Dried lacquer: pungent, bitter, temperature; Poisonous.Return liver, stomach warp.Desinsection, for malnutrition due to parasitic infestation, stomachache, roundworm, pinworm etc., can be with insecticide with using.
Tawny daylily: taste is sweet, cool in nature.Reducing fever and causing diuresis, cooling blood and hemostasis.According to modern pharmacology research, Daylily Root all has certain inhibitory action to blood fluke, tulase.
Wild cigarette: taste is pungent, cold in nature, greatly poison; Expelling wind and activating blood flow is clearing heat and detoxicating.Main rheumatalgia pain, traumatic injury, the carbuncle furunculosis that swells, mumps, acute tonsillitis, snake bite and insect sting.< < Simao, Yunnan Chinese herbal medicine selects > > to carry: " clearing heat and detoxicating, stimulate the circulation of the blood and cause the muscles and joints to relax.Control parotitis, traumatic injury, rheumatalgia, acute filthy disease.”
Myrobalan: taste acid, bitter, property is flat; Enter lung, large intestine channel.Modern medicine study confirmation, the hydrochloric acid of these product, the ethanol extract of extracted by ether have stronger antibacterial action, and have antimycotic effect.
Chinese torreyanut: taste is sweet, puckery, property is flat.Enter spleen, large intestine channel.Desinsection, disappears long-pending, expelling parasite.The Chinese torreyanut property of medicine is gentle, the efficacy of a drug is reliable.
Euphorbiae fischerianae: bitter, pungent, property is flat, poisonous; The thoughts of returning home, lung channel.Broken long-pending desinsection, removing dampness to relieve itching.For scrofula, bone tuberculosis, cutaneous tuberculosis, trichophytosis, neurodermatitis, chronic bronchitis, Trichomonas vaginalis.
Needle juniper fruit: antibacterial, convergence, promote to scab, purify, sterilize, profit nerve, desinsection, practise midwifery; Cure mainly eczema, chronic eczema and the swelling of pore obstruction, dermatitis, stream soup.
Golden Larch Bark: taste is pungent, warm in nature, poisonous; Return lung, the spleen channel.Desinsection, antipruritic.Modern medicine study confirmation, Golden Larch Bark on cell proliferation has obvious inhibitory action.
The capsule of weeping forsythia: bitter, cold nature, returns lung, the heart, gallbladder channel.Clearing heat and detoxicating, dispersing swelling and dissipating binds, dispelling wind and heat from the body.Cure mainly carbuncle sore tumefacting virus, subcutaneous nodule scrofula, affection of exogenous wind-heat, warm disease from the beginning of, heat is drenched puckery pain etc.< < herbal classic > > carries: " main fever and chills, mouse impotence, scrofula, the swollen sore of disliking of carbuncle, goiter and tumor, knot heat." modern medicine study confirmation, capsule of weeping forsythia concentrated decoction has antibacterial action in vitro, can suppress typhoid bacillus, paratyphosum Bacterium, Escherichia coli, shigella dysenteriae, diphtheria bacillus and comma bacillus, staphylococcus, streptococcus etc.
Short-tube lycoris: taste is pungent, sweet, warm in nature, slightly poisonous.Detumescence, desinsection.Scrofula is controlled in external application, furunculosis furuncle, and rheumatic arthritis, snake bite, oedema, the maggot of going out, kills mouse.
Kitchen garden: cold in nature, the sweet acid of taste; Enter the heart, liver, spleen, large intestine channel.Have that hygroscopic is antipruritic, clearing heat for detumescence, clearing heat and detoxicating, Li Shui dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of the cool blood that stops blooding.Kitchen garden has stronger inhibitory action to shigella dysenteriae, typhoid bacillus and Escherichia coli, can be used for the supplemental treatment of various inflammation, have the title of " natural antibiotics ".
Dark plum: sour-puckery flavor, warm in nature; Enter lung, spleen, large intestine channel.Astringe the lung, puckery intestines, promote the production of body fluid to quench thirst, antibacterial, claming ascaris.Cure mainly chronic cough, rush down for a long time, protracted dysentery has blood in stool, the ascariasis of biliary tract, polydipsia, the diseases such as vomiting.Modern medicine study confirmation, dark plum is comparatively suitable to protracted dysentery (especially bloody flux), can suppress the pathogenic entero becterias such as shigella dysenteriae and second kind hemolytic streptococcus.
The present invention compared with prior art, has following beneficial effect:
Clinical laboratory of the present invention takes from natural component with thimerosal, for pure Chinese medicinal preparation, and adopt modern advanced medical pharmaceutical technology to make, have that sterilizing ability is strong, speed of action is fast, good stability, the advantage such as be easy to get that avirulence, non-corrosiveness, excitant be little, soluble in water, cheap, and safe and harmless to humans and animals, environmental pollution degree is low, be a kind of desirable broad-spectrum disinfectant liquid.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of thimerosal active ingredient of the present invention forms and weight is:
A preparation method for thimerosal for clinical laboratory, comprises following processing step:
(1) Radix Angelicae Sinensis, blue gum, cogongrass rhizome, dried lacquer, tawny daylily, Chinese torreyanut, the capsule of weeping forsythia and short-tube lycoris are put into container, add 5 times of water gagings, soak after 2-3 hour, decoct continuously three times, decoct three hours at every turn, after each decoction, extract decoction liquor, finally merge the decoction liquor of extracting for three times, filter, obtain filtrate, standby;
(2) by bark of official magnolia chopping, put into pot, add 0.5 times of amount yellow rice wine, intense fire is fried to micro-Huang, takes out, and dries, and grinds into powder, crosses 200 order fine powders, standby;
(3) myrobalan is smashed to pieces, put into container, add the ethanol of 0.5 times of amount, soak after 2～3 hours, filter, get filtrate, standby;
(4) wild cigarette, euphorbiae fischerianae, needle juniper fruit and kitchen garden are cleaned, put into container, smash to pieces, stay juice standby;
(5) get Golden Larch Bark and put into mortar, grind into powder, cross 120 order fine powders, standby;
(6) get dark plum and clean, with vinegar, mix thoroughly, slow fire is vexed to be moistened while being sucked to vinegar, puts suitable container interior airtight, with steam heated 2-4 hour, takes out and is dried, and grinds into powder, crosses 200 order fine powders, standby;
(7) filtrate of gained in step (1)-(6), fine powder and juice are mixed, after mediation, utilize modern advanced pharmacy science and technology, make thimerosal, obtain described clinical laboratory's thimerosal.
Usage and dosage: get thimerosal of the present invention and be placed in thimerosal apparatus for placing, with the distilled water diluting of 5 times of amounts, for the every disinfection of clinical laboratory.
Embodiment 2
The raw material of thimerosal active ingredient of the present invention forms and weight is:
Thimerosal preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of thimerosal active ingredient of the present invention forms and weight is:
Thimerosal preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of thimerosal active ingredient of the present invention forms and weight number is:
Thimerosal preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Thimerosal of the present invention is carried out to bacteriostatic test below:
1, experimental strain: staphylococcus aureus, Pseudomonas aeruginosa, diphtheria bacillus.
2, bacterium culture medium: nutrient agar and nutrient broth medium.
3, bacteriostatic test divides experimental group and control group, experimental group taste thimerosal of the present invention, and control group is selected 84 thimerosals.
4, concrete test procedure:
(1) preparation of bacterium liquid: above-mentioned three kinds of bacterial classifications are inoculated in respectively on three agar mediums, at 37 ℃, cultivate 24 hours, therefrom picking colonies typical is inoculated in respectively in three fresh nutrient broth mediums respectively, synthermal under, cultivate 18 hours, standby;
(2) get respectively thimerosal of the present invention and each 60ml of 84 thimerosals, be placed in respectively cut-back tank, it is diluted respectively to 20 times, above-mentioned two kinds of dilution solution are split respectively in three containers, be placed under aseptic condition, standby;
(3) experimental strain of above-mentioned steps (1) being supported 18 hours through nutrition broth cultivation dilutes respectively 100 times with aseptic nutrient broth, and every kind of bacterial classification is sub-packed in two culture dishes, respectively mark control group and experimental group;
(4) dilute solution of three parts of thimerosals of the present invention of above-mentioned steps (2) gained is splashed into respectively to experimental group culture dish, three part of 84 thimerosal dilute solution splashes into respectively control group culture dish.
5, experimental observation is measured:
Above-mentioned test is observed, observed two groups of bacterial classification number change and measure bacterial classification revolution mark concrete outcome and as above show.
6, after observation is measured, above-mentioned culture dish is all placed under aseptic condition standing two days, after liquid to be sterilized volatilizees completely, tracing observation finds, control group bacterium colony continues breeding, and experimental group bacterium colony is unchanged.
7, experimental result:
The sterilizing ability of experimental group thimerosal is much larger than the thimerosal of control group, and can suppress bacterial classification and continue breeding.
Clinical laboratory of the present invention takes from natural component with thimerosal, for pure Chinese medicinal preparation, and adopt modern advanced medical pharmaceutical technology to make, have that sterilizing ability is strong, speed of action is fast, good stability, the advantage such as be easy to get that avirulence, non-corrosiveness, excitant be little, soluble in water, cheap, and safe and harmless to humans and animals, environmental pollution degree is low, be a kind of desirable broad-spectrum disinfectant liquid.
Claims (5)
1.Yi Zhong clinical laboratory thimerosal, is characterized in that: raw material composition and the parts by weight of making described thimerosal active ingredient are:
Radix Angelicae Sinensis 50-80 part blue gum 50-80 part cogongrass rhizome 48-75 part bark of official magnolia 45-75 part
The wild cigarette 45-70 of dried lacquer 45-75 part tawny daylily 45-72 part part myrobalan 45-67 part
Chinese torreyanut 40-65 part euphorbiae fischerianae 40-60 part needle juniper fruit 35-60 part Golden Larch Bark 35-65 part
Capsule of weeping forsythia 35-65 part short-tube lycoris 30-60 part kitchen garden 30-50 part dark plum 30-50 part.
2. a kind of clinical laboratory according to claim 1 thimerosal, is characterized in that: the raw material of making described thimerosal active ingredient forms and parts by weight are:
Radix Angelicae Sinensis 55-75 part blue gum 55-75 part cogongrass rhizome 53-71 part bark of official magnolia 50-70 part
The wild cigarette 50-65 of dried lacquer 50-70 part tawny daylily 49-68 part part myrobalan 50-64 part
Chinese torreyanut 45-60 part euphorbiae fischerianae 44-56 part needle juniper fruit 40-55 part Golden Larch Bark 40-60 part
Capsule of weeping forsythia 40-60 part short-tube lycoris 35-55 part kitchen garden 34-46 part dark plum 34-46 part.
3. a kind of clinical laboratory according to claim 1 thimerosal, is characterized in that: the raw material of making described thimerosal active ingredient forms and parts by weight are:
Radix Angelicae Sinensis 60-70 part blue gum 60-70 part cogongrass rhizome 57-68 part bark of official magnolia 55-65 part
The wild cigarette 54-61 of dried lacquer 55-65 part tawny daylily 53-65 part part myrobalan 53-60 part
Chinese torreyanut 50-56 part euphorbiae fischerianae 48-52 part needle juniper fruit 44-51 part Golden Larch Bark 45-55 part
Capsule of weeping forsythia 45-55 part short-tube lycoris 40-50 part kitchen garden 38-42 part dark plum 38-42 part.
4. a kind of clinical laboratory according to claim 1 thimerosal, is characterized in that: the raw material of making described thimerosal active ingredient forms and parts by weight are:
60 parts of 62 parts of barks of official magnolia of 65 parts of cogongrass rhizomes of 65 parts of blue gums of Radix Angelicae Sinensis
57 parts of 58 parts of myrobalans of 60 parts of wild cigarettes of 60 portions of tawny daylilies of dried lacquer
50 parts of 48 parts of Golden Larch Barks of 50 parts of needle juniper fruits of 53 parts of euphorbiae fischerianaes of Chinese torreyanut
40 parts of 40 portions of dark plums of 45 portions of kitchen gardens of 50 portions of short-tube lycoris of the capsule of weeping forsythia.
5. the preparation method of thimerosal for clinical laboratory as described in claim 1-4 any one, is characterized in that: comprise following processing step:
(1) Radix Angelicae Sinensis, blue gum, cogongrass rhizome, dried lacquer, tawny daylily, Chinese torreyanut, the capsule of weeping forsythia and short-tube lycoris are put into container, add 5 times of water gagings, soak after 2-3 hour, decoct continuously three times, decoct three hours at every turn, after each decoction, extract decoction liquor, finally merge the decoction liquor of extracting for three times, filter, obtain filtrate, standby;
(2) by bark of official magnolia chopping, put into pot, add 0.5 times of amount yellow rice wine, intense fire is fried to micro-Huang, takes out, and dries, and grinds into powder, crosses 200 order fine powders, standby;
(3) myrobalan is smashed to pieces, put into container, add the ethanol of 0.5 times of amount, soak after 2～3 hours, filter, get filtrate, standby;
(4) wild cigarette, euphorbiae fischerianae, needle juniper fruit and kitchen garden are cleaned, put into container, smash to pieces, stay juice standby;
(5) get Golden Larch Bark and put into mortar, grind into powder, cross 120 order fine powders, standby;
(6) get dark plum and clean, with vinegar, mix thoroughly, slow fire is vexed to be moistened while being sucked to vinegar, puts suitable container interior airtight, with steam heated 2-4 hour, takes out and is dried, and grinds into powder, crosses 200 order fine powders, standby;
(7) filtrate of gained in step (1)-(6), fine powder and juice are mixed, after mediation, make thimerosal, obtain described clinical laboratory's thimerosal.
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| CN104542742A (en) * | 2013-10-12 | 2015-04-29 | 青岛锦涟鑫商贸有限公司 | Traditional Chinese medicine line incense for helping sleeping |
| CN104304352A (en) * | 2014-10-08 | 2015-01-28 | 鞠珍红 | Traditional Chinese medicament used for air disinfection of operating room and preparation method of traditional Chinese medicament |
| CN104435562A (en) * | 2014-11-02 | 2015-03-25 | 王孝芹 | Traumatic sterilization and inflammation-diminishing medicine for laboratory department and preparation methods thereof |
| CN104324277B (en) * | 2014-11-29 | 2017-10-20 | 刘娟 | A kind of disinfection of Chinese drug liquid medicine |
| CN104474566B (en) * | 2014-12-12 | 2017-09-29 | 刘纪刚 | A kind of chlorination equipment and thimerosal of clinical laboratory's testing instruments |
| CN104606629A (en) * | 2014-12-26 | 2015-05-13 | 刘永云 | Traditional Chinese medicine disinfection solution for clinical laboratory |
| CN104645117A (en) * | 2015-03-13 | 2015-05-27 | 李良学 | Traditional Chinese medicine disinfectant for clinical laboratory |
| CN104815211A (en) * | 2015-04-30 | 2015-08-05 | 山东大学齐鲁医院 | Disinfectant for clinical lab and preparation method of disinfectant |
| CN105123816A (en) * | 2015-10-20 | 2015-12-09 | 王明儒 | Sterilizing and disinfecting liquid for clinical laboratory and preparation method |
| CN105284953A (en) * | 2015-11-27 | 2016-02-03 | 孟伟 | Traditional Chinese medicine preparation used for disinfecting apparatus of clinical laboratory |
| CN105532751A (en) * | 2016-01-15 | 2016-05-04 | 王芳 | Disinfectant for laboratory department |
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| CN1362133A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano infantile eczema treating medicine and its preparation |
| CN1446531A (en) * | 2002-03-22 | 2003-10-08 | 董景平 | Disinfection attendance liquid prepared from Chinese herbal medicine and its production methods |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362133A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano infantile eczema treating medicine and its preparation |
| CN1446531A (en) * | 2002-03-22 | 2003-10-08 | 董景平 | Disinfection attendance liquid prepared from Chinese herbal medicine and its production methods |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
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