CN103768405B - A kind of Traditional Chinese medicine disinfectant and preparation method - Google Patents
A kind of Traditional Chinese medicine disinfectant and preparation method Download PDFInfo
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Abstract
The present invention relates to a kind of Traditional Chinese medicine disinfectant and preparation method, the raw material making described thimerosal active ingredient consists of: the Bi roots of grass, litharge, the stem of noble dendrobium, bee venom, emblic leafflower leaf, xanthorrhiza, saururus chinensis, the bark of ash, camphortree leaf, swallow tail, nephelium lappaceum, mile swertia herb, fungus-infected rice spike, witloof, folium sennae and greater celandine; Traditional Chinese medicine disinfectant sterilizing ability of the present invention is strong, speed of action is fast, stability is strong, non-stimulated to human body skin, and soluble in water, use rear noresidue, safe without toxic side effect, can be widely used in the sterilization of clinical laboratory personnel skin, medicine equipment and medical space etc., be a kind of desired sanitisation liquid be worthy to be popularized.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of Traditional Chinese medicine disinfectant and preparation method.
Background technology
When medical institutions carry out medical test, the bacterial flora system of checking system should minimize, this trier just needed medical personnel itself and inspection institute carries out omnibearingly sterilizing thoroughly, eliminate a series of bacterium and pathogen such as staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, proteus vulgaris etc., for checking system provides good environment.
The section office that clinical laboratory chemically examines as hospital inspection; often can extract sample to some patients to test; and check need of work aseptically to carry out; inspection specimen is mixed into prevent bacterium, fungi and virus etc.; thus affect test effect, make assay inaccuracy, and inspection institute use bactericidal antiphlogistic medicine as the large multipair human body wounds such as the tincture of iodine, alcohol, Iodophor and skin irritant; what have even can cause allergic reaction, and even can cause the disease of skin such as dermatitis and eczema.
In addition, the sterilization of medical environment also has great importance for inspection work.For this reason, find a kind of safe, effectively and the thimerosal had no side effect for clinical laboratory's every inspection work by significant.
Summary of the invention
The invention provides a kind of Traditional Chinese medicine disinfectant and preparation method, Traditional Chinese medicine disinfectant sterilizing ability of the present invention is strong, speed of action is fast, stability is strong, non-stimulated to human body skin, and soluble in water, use rear noresidue, safe without toxic side effect, can be widely used in the sterilization of clinical laboratory personnel skin, medicine equipment and medical space etc., be a kind of desired sanitisation liquid be worthy to be popularized.
For achieving the above object, technical scheme of the present invention is implemented as follows:
A kind of Traditional Chinese medicine disinfectant, raw material composition and the parts by weight of making described thimerosal active ingredient are:
Raw material composition and the parts by weight of making described thimerosal active ingredient are:
Raw material composition and the parts by weight of making described thimerosal active ingredient are:
Raw material composition and the parts by weight of making described thimerosal active ingredient are:
A preparation method for Traditional Chinese medicine disinfectant, comprises following processing step:
(1) get the Bi roots of grass, the stem of noble dendrobium, bee venom, emblic leafflower leaf, the bark of ash, nephelium lappaceum and folium sennae decontamination to clean, be placed in container, after adding distilled water immersion 4-6 hour of 8-10 times amount, boil 3-4 hour, extract; Again add 5-7 times amount distilled water, boil 2-3 hour, extract; Finally, add 2-4 times amount distilled water, 1-2 hour is boiled in heating, extracts; Merge No. three extracts, filter, obtain filtrate for subsequent use;
(2) get litharge and fungus-infected rice spike decontamination, microwave drying is placed in mortar and grinds into powder, crosses 180 order fine powders, for subsequent use;
(3) get xanthorrhiza, saururus chinensis, swallow tail, mile swertia herb and witloof decontamination to clean, be placed in container, add the alcohol solution dipping 2-3 hour of 80% of 5 times amount, heating is extracted after 5-6 hour, reclaims ethanol, filters, obtains filtrate, for subsequent use;
(4) get camphortree leaf and greater celandine decontamination, rub, add the distilled water of 3 times amount, stir filtration, and reserved filtrate is for subsequent use;
(5) by filtrate made for above-mentioned steps (1)-(4) and fine powder mixing, make thimerosal, be described Traditional Chinese medicine disinfectant.
The property of medicine of the present invention's Chinese medicine used is as follows:
The Bi roots of grass: taste is pungent, hot in nature; Return stomach, large intestine channel.Warming spleen and stomach for dispelling cold, lower gas pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, antimigraine; Control toothache outward.Modern medicine study confirms, the essential oil that Bi dials middle proposition all has inhibitory action to white and staphylococcus aureus and hay bacillus, Bacillus cereus, Escherichia coli, shigella dysenteriae etc.
Litharge: taste is salty, pungent, property is put down, poisonous; Enter liver, the spleen channel.Detumescence desinsection, restrains anticorrosion, promoting expectoration to arrest convulsion.Cure mainly hemorrhoid, pyogenic infections, ulcer, eczema, body odour, wound, protracted dysentery, frightened epilepsy." detailed outline " carries: " treat gastric disorder causing nausea, quench one's thirst, malaria, diarrhea.Hemostasis, desinsection, disappears long-pending.Control all sores, detumescence poison, except body odour.”
The stem of noble dendrobium: taste is sweet, light, property is put down; Enter stomach, lung, kidney channel.Promote the production of body fluid beneficial stomach, clearing heat and nourishing yin.Cure mainly consumption of body fluid caused by febrile disease, dry polydipsia, after being ill abnormal heat, it is dark that the moon hinders order." book on Chinese herbal medicine is new again " carries: " reason stomach Qi, clearing stomach fire, removes polydipsia in the heart, treats kidney channel abnormal heat, arresting convulsion of calming the nerves, and separate night sweat, can fall apart heat." Tissue culture assays proves, stem of noble dendrobium decoction has retarding action to the cytopathy caused by orphan virus (ECHO11).
Bee venom: taste is pungent, bitter, property is put down, poisonous; Return liver, lung channel.Dispel rheumatism, pain relieving.Cure mainly rheumatic arthritis, psoas is ached, neuralgia, hypertension, nettle rash, asthma." pharmacognosy " carries: " pant to bronchi, first shape abscess, some high blood pressure, rheumatism and abscess be effective." modern medicine study confirmation, bee venom can be antibacterial, can bacteria growing inhibiting with the bee venom aqueous solution of 1: 50000.
Emblic leafflower leaf: sweet, the micro-hardship of taste, cool in nature; The thoughts of returning home, liver, large intestine channel.Clearing heat and detoxicating, inducing diuresis and reducing edema.Cure mainly aphtha, furunculosis, eczema, dermatitis, oedema, hypertension, venomous snake bite, traumatic injury." Luchuan book on Chinese herbal medicine " carries: " corruption is gone in sterilization.Control mouth rotten, the skin diseases of the scrota and infantile malnutrition due to digestive disturbances or intestinalparasites, malignant boil, leakage, hemorrhoid.”
Xanthorrhiza: mildly bitter flavor, cool in nature.Cooling blood and hemostasis, dampness removing removing jaundice.For leukemia, alpastic anemia, bleeding gums, hepatitis, urinary tract infections.Modern medicine study confirms, the xanthorrhiza preparation extracted with rare alcohol reflux, has height antibacterial action, have moderate antibacterial action to beta streptococcus, streptococcus pneumonia, typhoid bacillus, diphtheria bacillus and shigella flexneri to staphylococcus aureus, bacillus anthracis.
Saururus chinensis: taste is sweet, pungent, cold in nature; Return lung, spleen, stomach, large intestine channel.Clearing away heat and promoting diuresis, removing toxicity for detumescence.Cure mainly heat to drench, blood drenches, oedema, beriberi, jaundice, dysentery, under band, and carbuncle sore tumefacting virus, eczema, snake bite.Modern medicine study confirms, the obvious antiinflammatory action of hyperin tool contained by saururus chinensis, and 50% decoction has inhibitory action to staphylococcus aureus, typhoid bacillus, and has the effect of stronger antitussive action and suppression eye aldose reductase.
The bark of ash: bitter, cold in nature; Return liver, courage, large intestine channel.Heat-clearing and damp-drying drug, clears liver and improve vision, and inducing astrigency stops dysentery, only band.Cure mainly and rush down dysentery for hot poison, the lower pruritus vulvae of band, the hot red eye, swell pain of liver, the raw ocular of order.Modern medicine study confirms, bark of ash decoction all has inhibitory action to staphylococcus aureus, Escherichia coli, shigella flexneri, bacterium sonnei, also has certain inhibitory action, as resisiting influenza virus, herpes virus etc. to virus.
Camphortree leaf: taste is pungent, warm in nature; The thoughts of returning home, spleen, lung channel.Dispel rheumatism, removing toxic substances desinsection.Cure mainly arthralgia due to wind-dampness, stomachache, scald, sore swollen toxin, chronic ulcer of lower limb, mange, pruitus, insect-bite." Luchuan book on Chinese herbal medicine " carries: " mange is controlled in desinsection, sterilization.”
Swallow tail: bitter, micro-sweet, warm in nature.Invigorating the lung and benefiting vital QI, anti-inflammation and sterilization.Cure mainly dysentery, pulmonary tuberculosis, bronchitis; Drop into manure pit sump and kill maggot, wriggler.
Nephelium lappaceum: taste is sweet, sour, warm in nature; Return spleen, stomach warp.Loose cold, only dysentery, removing toxic substances.Cure mainly dysentery, trusted subordinate's crymodynia, sore." Luchuan book on Chinese herbal medicine " carries: " shell, anti-inflammation and sterilization.Control stomatitis, dysentery, wash ulcer.”
Mile swertia herb: bitter, cold in nature.Clearing heat and detoxicating, relaxing liver and strengthening stomach, anti-inflammation and sterilization.Cure mainly acute icteric hepatitis, sphagitis, tonsillitis, cystitis, urethritis, influenza, flu, malaria.
Fungus-infected rice spike: taste is micro-salty, property is put down; Return lung channel.Anti-inflammation and sterilization, clearing heat, relieving sore-throat, clearing heat and detoxicating, relieve sore throat.Cure mainly larynx numbness, abscess of throat.
Witloof: bitter, salty, cold in nature.Clearing liver cholagogic, stomach strengthening and digestion promoting, clearing heat and detoxicating, inducing diuresis to reduce edema.Cure mainly jaundice with damp-heat pathogen, nephritic dropsy, epigastric distending pain, poor appetite, for jaundice with damp-heat pathogen, stomachache food is few, oedema oliguria.Pharmacological evaluation shows, the ethanol of cichory root or ether extract have antibacterial, astriction.
Folium sennae: taste is sweet, bitter, cold in nature, slightly poisonous; Return large intestine channel.Cure mainly the row that purges heat stagnant, defaecation, Li Shui.Stagnate for thermojunction, constipation is suffered from abdominal pain, oedema turgor.Modern medicine study confirms, folium sennae immersion liquid has inhibitory action to various bacteria, as Escherichia coli, proteus, shigella dysenteriae, alpha streptococcus and Candida albicans and some pathogenic dermatophyte.
Greater celandine: bitter, cool in nature, poisonous; Return lung, the heart, kidney channel.Clearing heat and detoxicating, pain relieving cough-relieving.For gastritis, stomach ulcer, stomachache, enteritis, dysentery, jaundice, chronic bronchitis, pertussis; Paddy-field dermatitis is controlled in external application, insect-bite." Shanxi Chinese medicinal herbal " carries: " lower internal heat, brings down a fever antipyretic, anti-inflammation and sterilization, antalgic and sedative.”
The present invention compared with prior art, has following beneficial effect:
Traditional Chinese medicine disinfectant sterilizing ability of the present invention is strong, speed of action is fast, stability is strong, non-stimulated to human body skin, and soluble in water, use rear noresidue, safe without toxic side effect, can be widely used in the sterilization of clinical laboratory personnel skin, medicine equipment and medical space etc., be a kind of desired sanitisation liquid be worthy to be popularized.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Traditional Chinese medicine disinfectant active ingredient of the present invention and weight are:
Preparation method of the present invention, comprises following processing step:
(1) get the Bi roots of grass, the stem of noble dendrobium, bee venom, emblic leafflower leaf, the bark of ash, nephelium lappaceum and folium sennae decontamination to clean, be placed in container, after adding distilled water immersion 4-6 hour of 8-10 times amount, boil 3-4 hour, extract; Again add 5-7 times amount distilled water, boil 2-3 hour, extract; Finally, add 2-4 times amount distilled water, 1-2 hour is boiled in heating, extracts; Merge No. three extracts, filter, obtain filtrate for subsequent use;
(2) get litharge and fungus-infected rice spike decontamination, microwave drying is placed in mortar and grinds into powder, crosses 180 order fine powders, for subsequent use;
(3) get xanthorrhiza, saururus chinensis, swallow tail, mile swertia herb and witloof decontamination to clean, be placed in container, add the alcohol solution dipping 2-3 hour of 80% of 5 times amount, heating is extracted after 5-6 hour, reclaims ethanol, filters, obtains filtrate, for subsequent use;
(4) get camphortree leaf and greater celandine decontamination, rub, add the distilled water of 3 times amount, stir filtration, and reserved filtrate is for subsequent use;
(5) by filtrate made for above-mentioned steps (1)-(4) and fine powder mixing, make thimerosal, be described Traditional Chinese medicine disinfectant.
Embodiment 2
The raw material composition of Traditional Chinese medicine disinfectant active ingredient of the present invention and weight are:
The present embodiment disinfection of Chinese drug liquid and preparation method thereof and using method processing step identical with embodiment 1.
Embodiment 3
The raw material composition of Traditional Chinese medicine disinfectant active ingredient of the present invention and weight are:
The present embodiment disinfection of Chinese drug liquid and preparation method thereof and using method processing step identical with embodiment 1.
Embodiment 4
The raw material composition of Traditional Chinese medicine disinfectant active ingredient of the present invention and weight are:
The present embodiment disinfection of Chinese drug liquid and preparation method thereof and using method processing step identical with embodiment 1.
Bacteriostatic experiment is carried out to thimerosal of the present invention below:
1, experimental strain:
Select the bacterial classification that laboratory is representative, staphylococcus aureus, candida albicans and Pseudomonas aeruginosa.
2, bacterium culture medium:
Nutrient agar and nutrient broth medium.
3, experiment classification:
Bacteriostatic experiment divides experimental group and control group, and experimental group selects Traditional Chinese medicine disinfectant of the present invention, and control group selects hypochlorous acid thimerosal.
4, specific experiment step:
(1) preparation of bacterium liquid
Be inoculated on three agar mediums respectively by above-mentioned three kinds of bacterial classifications, cultivate 36 hours under 370C, from above-mentioned agar medium, picking colonies typical is inoculated in three fresh nutrient broth mediums respectively respectively, under synthermal, cultivates 24 hours, for subsequent use.
(2) thimerosal is selected
Get Traditional Chinese medicine disinfectant of the present invention and each 45ml of hypochlorous acid thimerosal, be placed in cut-back tank respectively, 30 times are diluted respectively to it, above-mentioned two kinds of dilution solution are placed in three containers respectively, under being placed in aseptic condition, for subsequent use.
(3) bacterial classification packing and mark
The experimental strain that above-mentioned steps (1) is supported 24 hours through nutrition broth cultivation is diluted 50 times respectively with aseptic nutrient broth, and often kind of bacterial classification is sub-packed in two culture dishes, marks control group and experimental group respectively.
(4) sterilization
The dilute solution of the two g Traditional Chinese medicine disinfectant of the present invention of above-mentioned steps (2) gained is instilled experimental group culture dish respectively, and two g hypochlorous acid thimerosal dilute solutions instill control group culture dish respectively.
5, experimental observation is measured:
Above-mentioned experiment is observed, observes three groups of bacterial classifications and measure bacterial classification revolution mark, and recording observed data result.
6, after observation is measured, leave standstill two days under above-mentioned culture dish being all placed in aseptic condition, after liquid to be sterilized volatilizees completely, tracing observation finds, control group bacterium colony continues breeding, and experimental group bacterium colony is unchanged.
7, experimental result:
The sterilizing ability of experimental group Traditional Chinese medicine disinfectant of the present invention much larger than the sterilizing ability of control group thimerosal, and can suppress bacterial classification to continue breeding.
Claims (5)
1. a Traditional Chinese medicine disinfectant, is characterized in that: raw material composition and the parts by weight of making described thimerosal active ingredient are:
Bi roots of grass 36-52 part litharge 36-52 part stem of noble dendrobium 35-50 part bee venom 35-50 part
Emblic leafflower leaf 30-52 part xanthorrhiza 26-47 part saururus chinensis 26-47 part bark of ash 26-47 part
Camphortree leaf 22-39 part swallow tail 22-39 part nephelium lappaceum 20-39 part mile swertia herb 16-35 part
Fungus-infected rice spike 18-35 part witloof 15-32 part folium sennae 13-28 part greater celandine 12-26 part.
2. a kind of Traditional Chinese medicine disinfectant according to claim 1, is characterized in that: raw material composition and the parts by weight of making described thimerosal active ingredient are:
The Bi roots of grass 48 parts of litharges 48 parts of stems of noble dendrobium 46 parts of bee venom 46 parts
Emblic leafflower leaf 47 parts of xanthorrhizas 42 portions of saururus chinensis 42 parts of barks of ash 42 parts
Camphortree leaf 34 parts of swallow tails, 34 parts of nephelium lappaceums 33 parts of mile swertia herbs 30 parts
Fungus-infected rice spike 30 portions of witloofs 27 portions of folium sennaes 23 portions of greater celandines 21 parts.
3. a kind of Traditional Chinese medicine disinfectant according to claim 1, is characterized in that: raw material composition and the parts by weight of making described thimerosal active ingredient are:
The Bi roots of grass 44 parts of litharges 44 parts of stems of noble dendrobium 42 parts of bee venom 42 parts
Emblic leafflower leaf 40 parts of xanthorrhizas 36 portions of saururus chinensis 36 parts of barks of ash 36 parts
Camphortree leaf 30 parts of swallow tails, 30 parts of nephelium lappaceums 28 parts of mile swertia herbs 25 parts
Fungus-infected rice spike 25 portions of witloofs 22 portions of folium sennaes 19 portions of greater celandines 18 parts.
4. a kind of Traditional Chinese medicine disinfectant according to claim 1, is characterized in that: raw material composition and the parts by weight of making described thimerosal active ingredient are:
The Bi roots of grass 40 parts of litharges 40 parts of stems of noble dendrobium 38 parts of bee venom 38 parts
Emblic leafflower leaf 33 parts of xanthorrhizas 30 portions of saururus chinensis 30 parts of barks of ash 30 parts
Camphortree leaf 26 parts of swallow tails, 26 parts of nephelium lappaceums 23 parts of mile swertia herbs 20 parts
Fungus-infected rice spike 20 portions of witloofs 17 portions of folium sennaes 15 portions of greater celandines 15 parts.
5. the preparation method of Traditional Chinese medicine disinfectant as described in any one of claim 1-4, is characterized in that: comprise following processing step:
(1) get the Bi roots of grass, the stem of noble dendrobium, bee venom, emblic leafflower leaf, the bark of ash, nephelium lappaceum and folium sennae decontamination to clean, be placed in container, after adding distilled water immersion 4-6 hour of 8-10 times amount, boil 3-4 hour, extract; Again add 5-7 times amount distilled water, boil 2-3 hour, extract; Finally, add 2-4 times amount distilled water, 1-2 hour is boiled in heating, extracts; Merge No. three extracts, filter, obtain filtrate for subsequent use;
(2) get litharge and fungus-infected rice spike decontamination, microwave drying is placed in mortar and grinds into powder, crosses 180 order fine powders, for subsequent use;
(3) get xanthorrhiza, saururus chinensis, swallow tail, mile swertia herb and witloof decontamination to clean, be placed in container, add the alcohol solution dipping 2-3 hour of 80% of 5 times amount, heating is extracted after 5-6 hour, reclaims ethanol, filters, obtains filtrate, for subsequent use;
(4) get camphortree leaf and greater celandine decontamination, rub, add the distilled water of 3 times amount, stir filtration, and reserved filtrate is for subsequent use;
(5) by filtrate made for above-mentioned steps (1)-(4) and fine powder mixing, make thimerosal, be described Traditional Chinese medicine disinfectant.
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| CN104173653A (en) * | 2014-08-29 | 2014-12-03 | 张海燕 | Liquid traditional Chinese medicine for preoperative hand disinfection and preparation method thereof |
| CN104542740A (en) * | 2015-01-27 | 2015-04-29 | 王淑芹 | Traditional Chinese medicine disinfectant for sterilization and disinfection of clinical laboratory instruments and preparation method of traditional Chinese medicine disinfectant |
| CN104645175A (en) * | 2015-03-13 | 2015-05-27 | 龚灿锋 | Traditional Chinese medicine disinfection liquid for clinical laboratory |
| CN104800801A (en) * | 2015-04-26 | 2015-07-29 | 卢洪文 | Chinese herbal preparation for sterilization and disinfection for laboratory departments and preparation method of Chinese herbal preparation |
| CN105053073A (en) * | 2015-08-18 | 2015-11-18 | 王子乐 | Traditional Chinese medicine disinfectant for operating room disinfection and preparation method for traditional Chinese medicine disinfectant |
| CN105284952A (en) * | 2015-11-25 | 2016-02-03 | 臧琳琳 | Special disinfectant for examination apparatuses in clinical laboratory, and preparation method thereof |
| CN105475377A (en) * | 2016-01-21 | 2016-04-13 | 苏州派腾生物医药科技有限公司 | Naturally fragrant air disinfectant |
| CN106070386A (en) * | 2016-06-29 | 2016-11-09 | 杨莉 | The Chinese medicine liquid medicine of a kind of control laboratory sterilizing and preparation method |
| CN106234465A (en) * | 2016-07-28 | 2016-12-21 | 柳州市明达鸽业养殖专业合作社 | Sustained disinfectant that Denmark Wang Ge is special and preparation method thereof |
| CN106234464A (en) * | 2016-07-28 | 2016-12-21 | 柳州市明达鸽业养殖专业合作社 | Logical sequence takes off special sustained disinfectant of Columba livia and preparation method thereof |
| CN107158251A (en) * | 2017-07-12 | 2017-09-15 | 合肥华盖生物科技有限公司 | A kind of Traditional Chinese medicine disinfectant and preparation method thereof |
| CN108576082A (en) * | 2018-01-24 | 2018-09-28 | 合肥华盖生物科技有限公司 | A kind of novel disinfectant liquid and preparation method thereof |
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| CN101961035A (en) * | 2009-07-24 | 2011-02-02 | 刘彧 | Traditional Chinese medicine disinfectant |
| CN102113524A (en) * | 2010-12-30 | 2011-07-06 | 戴锐 | Chinese medicinal disinfectant |
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