CN105597112A - Method for preparing type-B ultrasonic coupling powder - Google Patents
Method for preparing type-B ultrasonic coupling powder Download PDFInfo
- Publication number
- CN105597112A CN105597112A CN201610028754.7A CN201610028754A CN105597112A CN 105597112 A CN105597112 A CN 105597112A CN 201610028754 A CN201610028754 A CN 201610028754A CN 105597112 A CN105597112 A CN 105597112A
- Authority
- CN
- China
- Prior art keywords
- liquid
- powder
- type
- ultrasonic
- ultrasonic coupling
- Prior art date
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- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 10
- 230000008878 coupling Effects 0.000 title claims abstract description 9
- 238000010168 coupling process Methods 0.000 title claims abstract description 9
- 238000005859 coupling reaction Methods 0.000 title claims abstract description 9
- 238000000034 method Methods 0.000 title abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 239000012153 distilled water Substances 0.000 claims abstract description 8
- 210000003022 colostrum Anatomy 0.000 claims description 5
- 235000021277 colostrum Nutrition 0.000 claims description 5
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 7
- 239000000839 emulsion Substances 0.000 abstract description 4
- 239000006185 dispersion Substances 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 239000007822 coupling agent Substances 0.000 abstract 3
- 239000010977 jade Substances 0.000 abstract 3
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 abstract 2
- 229940057995 liquid paraffin Drugs 0.000 abstract 2
- 229960000907 methylthioninium chloride Drugs 0.000 abstract 2
- 229950008882 polysorbate Drugs 0.000 abstract 2
- 229920000136 polysorbate Polymers 0.000 abstract 2
- 238000007865 diluting Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- NNBFNNNWANBMTI-UHFFFAOYSA-M brilliant green Chemical compound OS([O-])(=O)=O.C1=CC(N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 NNBFNNNWANBMTI-UHFFFAOYSA-M 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
Landscapes
- Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a method for preparing type-B ultrasonic powder. The method includes steps of adding an appropriate quantity of methylene blue and 80-100 ml of polysorbate into 400 ml of distilled water and uniformly stirring the methylene blue, the polysorbate and the water to obtain jade green transparent viscous liquid; slowing adding liquid paraffin into the jade green transparent viscous liquid and quickly and forcibly stirring the liquid paraffin and the jade green transparent viscous liquid to form primary emulsion; diluting the primary emulsion by the aid of remaining distilled water until a full quantity of liquid is obtain, dripping an appropriate quantity of essence into the liquid, uniformly stirring the essence and the liquid to obtain the type-B ultrasonic coupling powder and separately filling dry, sterile and clean containers with the type-B ultrasonic coupling powder. Compared with the prior art, the method has the advantages that coupling agents are prepared by the aid the dispersion method, and the method is simple in process and short in elapsed time; the coupling agents are applied for nearly a year, as clinically observed in more than 2000 cases, the coupling agents are excellent in air isolation performance, probes can be effectively protected, images are clear, and the type-B ultrasonic coupling powder is suitable to be used as a medical preparation.
Description
Technical field
The present invention relates to medical technical field, particularly a kind of preparation method of B ultrasonic coupling powder.
Background technology
B ultrasonic couplant be generally with sodium alginate, sodium carboxymethylcellulose or carbomer etc. add water, that glycerine or propane diols are made is stickyThick semisolid preparation. In process for preparation, be scattered in water or heating bath, or with alcohol disperse be dissolved in water, consuming time generallyLong.
Summary of the invention
The preparation method who the object of this invention is to provide a kind of B ultrasonic coupling powder, selects atoleine as one of raw material, uses medicamentLearn relevant emulsion preparation theory, manufactured experimently a kind of B ultrasonic couplant, obtained good clinical effectiveness.
For achieving the above object, the present invention adopts following technical proposals:
A preparation method for B ultrasonic coupling powder, comprises the following steps: get distilled water 400ml, add appropriate methylenum careuleum and add poly-Sorb ester 80-100ml stirs evenly, and can obtain emerald green transparent thick liquid; Then slowly add atoleine, and firmly stir rapidly,Form colostrum; Colostrum is diluted to full dose with remaining distilled water, drips appropriate essence, stir evenly, be sub-packed in dry aseptic clearIn clean container.
The present invention compared with prior art, has following beneficial effect:
(1) this couplant adopts dispersion method preparation, and technique is simple, consuming time short.
(2) this couplant is applied nearly 1 year through 2000 many cases clinical observations, and isolated air is functional, can protect preferably spyHead, image is also very clear, the suitable medical preparation of doing.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is done further and supplemented, but do not limit the present invention in any way.
Prescription
Atoleine 300ml, polyoxyethylene sorbitan monoleate-100ml, distilled water 600ml, 1% methylenum careuleum is appropriate, and essence is appropriate.
Preparation technology
Get distilled water 400ml, add appropriate methylenum careuleum and add polyoxyethylene sorbitan monoleate-100ml to stir evenly, can obtain emerald green transparent thicknessLiquid; Then slowly add atoleine, and firmly stir rapidly, form colostrum; Colostrum is diluted with remaining distilled waterTo full dose, drip appropriate essence, stir evenly, be sub-packed in dry aseptic clean container.
Quality control
Proterties
This product is light green transparent emulsion.
Acid-base value
Get this product 10g, adding distil water 100ml dissolves it, and measured value is 7.0 ± 0.5.
Microbial limit
Conform with the regulations according to the inspection of limit test of microbe method according to two annex of Chinese pharmacopoeia.
Stability test
Reserved sample observing
Room temperature (25 ± 5) DEG C airtight placement 6 months, slightly moisture loses, and color is unchanged; Be placed in 5 DEG C of refrigerators and protectDeposit 6 months, proterties, acid-base value are without significant change.
Centrifugal observation
From different batches, choose 2 parts of this product, every part of 10g, with the centrifugal 15min of speed of 4000r/min, this product is without layeringPhenomenon.
Irritation test
Get 3 of healthy adult rabbit, get 3 positions shave hair at back, area is respectively 2.5cm2, after 24h, shave mao position evenSmear this product 0.5g, then observe after 24h, without phenomenons such as erythema, swelling, bubbles.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for those skilled in the art, the present invention can have various modifications and variations. Within the spirit and principles in the present invention all, any amendment of doing, etc.With replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (1)
1. a preparation method for B ultrasonic coupling powder, is characterized in that: comprise the following steps: get distilled water 400ml, add appropriateMethylenum careuleum also adds polyoxyethylene sorbitan monoleate-100ml to stir evenly; Then slowly add atoleine, and firmly stir rapidly, at the beginning of formingBreast; Colostrum is diluted to full dose with remaining distilled water, drips appropriate essence, stir evenly, be sub-packed in dry aseptic clean containerIn.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610028754.7A CN105597112A (en) | 2016-01-18 | 2016-01-18 | Method for preparing type-B ultrasonic coupling powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610028754.7A CN105597112A (en) | 2016-01-18 | 2016-01-18 | Method for preparing type-B ultrasonic coupling powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105597112A true CN105597112A (en) | 2016-05-25 |
Family
ID=55977814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610028754.7A Pending CN105597112A (en) | 2016-01-18 | 2016-01-18 | Method for preparing type-B ultrasonic coupling powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105597112A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645360A (en) * | 2015-03-06 | 2015-05-27 | 青岛大学附属医院 | Coupling agent for B-mode ultrasound ultrasonography and preparation method thereof |
-
2016
- 2016-01-18 CN CN201610028754.7A patent/CN105597112A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104645360A (en) * | 2015-03-06 | 2015-05-27 | 青岛大学附属医院 | Coupling agent for B-mode ultrasound ultrasonography and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李全斌等.: "介绍一种B超耦合剂的制备方法", 《卫生职业教育》 * |
| 马乐嘶等.: "B超耦合剂的制备", 《黑龙江医学》 * |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160525 |
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| RJ01 | Rejection of invention patent application after publication |