CN107537043A - A kind of novel cavity channel ultrasound gel for possessing bactericidal action and preparation method thereof - Google Patents
A kind of novel cavity channel ultrasound gel for possessing bactericidal action and preparation method thereof Download PDFInfo
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- CN107537043A CN107537043A CN201610528765.1A CN201610528765A CN107537043A CN 107537043 A CN107537043 A CN 107537043A CN 201610528765 A CN201610528765 A CN 201610528765A CN 107537043 A CN107537043 A CN 107537043A
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Abstract
The invention belongs to biomedicine field, discloses a kind of novel cavity channel ultrasound gel for possessing bactericidal action and preparation method thereof, composition includes chitosan, Triclosan, chlorhexidine acetate, polyoxyethylene sorbitan monoleate, carbomer, glycerine, triethanolamine, purified water.The present invention can continue to use the convenience of existing coupling gel, moreover it is possible to reach clear image；Greasy property is good；To corrosion-free damage of popping one's head in；It is non-stimulated to skin and mucosa, without allergy, it is absorbable the advantages that.Viscosity (25 DEG C) is not less than 15Pas in main performance；PH value 5.5~8.0；Can kill during the ultrasonic diagnosis and suppress probe fall with gram- bacteria, fecal coliform caused by human contact, Pseudomonas aeruginosa, cross-infection and the propagation such as fungi.It is clinically used for Vagina supersonic inspection, non-intact skin examination, proctoscopy, cystoscopy, examination by centesis, people at highest risk, severe infection patient inspection, all ultrasonic examinations in intensive care unit；Other all ultrasonic examinations can be safer.
Description
Technical field
The present invention relates to a kind of novel cavity channel ultrasound gel for possessing bactericidal action and preparation method thereof, can widely use
Medical supersonic in a variety of positions such as skin, cavity, puncture checks therapy field.
Background technology
Medical ultrasonic coupling agent is the indispensable medium in Ultrasonic Diagnosis and treatment.For medical supersonic, if allowed
Pop one's head in (or treatment head, similarly hereinafter) and skin " dry contact ", it is strong anti-due to thin layer of air (sometimes or thick-layer) between the two
The effect of penetrating, sending out ultrasonic wave can not be reached and enter human body at all, and Ultrasonic Diagnosis or treatment are not known where to begin at all.For that purpose it is necessary to
Certain material is filled between detecting head surface and skin, to drive away air, and formation makes ultrasonic wave smooth and undistorted propagation
Passage.This material is known as " medical ultrasonic coupling agent (medical ultrasonic couplant) ", because clinic pushes away
High formulation is gel, thus in english literature with more terms are " ultrasound coupling gel (ultrasonic
coupling gel)”.But couplant also plays the effect such as lubricant in clinical practice, what old friends were concerned about is more than its sound
Characteristic is learned, couplant also increasingly causes the concern of people using caused hospital-acquired infection risk.
Due to Intracavitary ultrasonography and the increasingly popularization for the treatment of, mucous membrane is weak in addition, subject to damage and infection, in the world most
To pay close attention to its clinical health and cross infection problem.On the basis of research and practice, some national government bodies and academic/
Some are formulated and issued to Industry body the file of directive significance very much, therefore issues all hospitals in the whole nation in Her Majesty the Queen in right of Canada as represented by the minister of Healt and bear
People is blamed, it is entitled《Come from ultrasound and the severe infection risk of medical gel》Notice in clear stipulaties：" for passing through group with device
Knit (such as aspirated with pin, with pin position and organize biopsy) all invasive operations, be related to sterilized environment and non-intact skin,
All operations carried out with the baby of baby monitor room, it is necessary to use sterilization type gel.
With the significantly popularization of both transvaginal ultrasonography, and in view of the punching rate of commodity sheath used in transvaginal probe up to 8~81%, is kept away
The punching rate of pregnant set is up to 0.9~2%, and probe and coupling gel still have the chance for contacting mucous membrane, and the sterilization type coupling gel is not
Common medical supersonic coupling gel is same as, it is added with sterilizing composition, can be killed during deagnostic test and suppress to visit
Cross-infection and propagation between each bacterium such as pathogenicity gram- bacteria, fungi caused by head and human contact；Effectively reduce patient
Infection risk.
In view of couplant use is more chaotic in clinical at present, multiple provinces defend planning commission and have issued regulation file, and cleaning is not
Close rule and use couplant situation, cavity medical ultrasonic coupling agent is built with what the acquisition of highest safe class defended that planning commission promotes the use of
View, the strict degree of risk for controlling hospital-acquired infection and cross-patient's infection.
The content of the invention
Technical problem solved by the invention is the defects of overcoming prior art, there is provided one kind can continue to use coupled it is solidifying
The convenience of glue, moreover it is possible to reach clear image；Greasy property is good；To corrosion-free damage of popping one's head in；It is non-stimulated to skin and mucosa, without mistake
The advantages that quick, absorbable.Viscosity (25 DEG C) is not less than 15Pas in main performance；PH value 5.5~8.0；It can be examined in Ultrasonic Diagnosis
Killed during looking into and suppress that probe falls with gram- bacteria, fecal coliform caused by human contact, Pseudomonas aeruginosa, fungi etc. are intersected
Infection and propagation.It is clinically used for Vagina supersonic inspection, non-intact skin examination, proctoscopy, cystoscopy, puncture inspection
Look into, people at highest risk, severe infection patient check, all ultrasonic examinations in intensive care unit；Other all ultrasonic examinations can more be pacified
Entirely.
The present invention another technical scheme be disclose a kind of novel cavity channel ultrasound gel for possessing bactericidal action and its
Preparation method, it is characterised in that：Preparation process is as follows：
Step 1, chitosan 1g is taken by weight, Triclosan 0.1g, chlorhexidine acetate 0.1g, add poly- sorb
80 common 1g of ester, adds purified water 100g, is well mixed；
Step 2, weigh carbomer 50g first add 300g purifying it is water-swellable, add the above-mentioned mixed solution prepared；
Step 3, after the solution is stirred, glycerine, triethanolamine are added, adjust viscosity and PH, make viscosity (25
DEG C) it is not less than 15Pas；PH value 5.5~8.0；1000g is settled to purified water.
The present invention has following obvious advantage and beneficial effect：
1st, present invention addition chitosan, Triclosan and chlorhexidine acetate are conventional disinfectant, performance
Securely and reliably, the unique proportioning found out by experiment can to greatest extent suppress and kill staphylococcus aureus, Pseudomonas aeruginosa,
Escherichia coli, Candida albicans, do not find allergic reaction in experiment.
2nd, the gel is different from common medical supersonic coupling gel, and it is added with sterilizing composition, can be in deagnostic test
During kill and suppress cross-infection between each bacterium such as pathogenicity gram- bacteria, fungi caused by probe and human contact and
Propagate；It is effective to ensure doctors and patients' health.
3rd, new coupling gel product cost of the invention is slightly higher compared with common coupling gel, but enters with similar effect
Substantially reduced if the mouth product such as sterilization type gel of the newest release of Sonoteth companies.
4th, preparation method of the present invention is through lot of experiments, it is possible to achieve industrialization, substantially increases production effect, reduces life
Produce cost.
5th, through patent searching " a kind of ultrasonic therapy couplant and preparation method thereof and packing device
(CN200510023048.5) ", the ultrasonic coupling agent includes metronidazole and antibiotic and anaesthetic, and China《Medical treatment
Apparatus supervision and management regulations》Middle clear stipulaties, medical device product must not contain medicine；Purposes is limited, and product of the present invention is strict
In accordance with state's laws regulation, clinic can be widely applied to.
Embodiment
The present invention is further described in detail with reference to way of example：
Embodiment one：Chitosan 1g, Triclosan 0.1g, chlorhexidine acetate 0.1g are taken by weight, are added poly-
80 common 1g of sorb ester, adds purified water 100g, is well mixed；Weighing carbomer 10g first adds 300g purifying water-swellable, adds
The above-mentioned mixed solution prepared；After the solution is stirred, add glycerine, each 10g of triethanolamine, regulation viscosity and
PH, viscosity (25 DEG C) is set to be not less than 15Pas；PH value 5.5~8.0；1000g is settled to purified water.
Embodiment two：Chitosan 2g, Triclosan 0.2g, chlorhexidine acetate 0.2g are taken by weight, are added poly-
Sorb ester 80 counts 2g, adds purified water 100g, is well mixed；Weighing carbomer 20g first adds 300g purifying water-swellable, adds
The above-mentioned mixed solution prepared；After the solution is stirred, glycerine, triethanolamine 20g are added, adjusts viscosity and PH,
Viscosity (25 DEG C) is set to be not less than 15Pas；PH value 5.5~8.0；1000g is settled to purified water.
Embodiment three：Chitosan 3g, Triclosan 0.3g, chlorhexidine acetate 0.3g are taken by weight, are added poly-
Sorb ester 80 counts 3g, adds purified water 100g, is well mixed；Weighing carbomer 30g first adds 300g purifying water-swellable, adds
The above-mentioned mixed solution prepared；After the solution is stirred, glycerine, triethanolamine 30g are added, adjusts viscosity and PH,
Viscosity (25 DEG C) is set to be not less than 15Pas；PH value 5.5~8.0；1000g is settled to purified water.
Below by way of it is demonstrated experimentally that Clinical practice product of the present invention can be killed during ultrasonic diagnosis and suppress to visit
Cross-infection and the propagation such as head falls with gram- bacteria, fecal coliform caused by human contact, Pseudomonas aeruginosa, fungi.
It is comprehensive to select in 100 samples, it is clinical to select respectively through skin part ultrasonic 50, Via vagina position ultrasound 35
Example, through site of puncture ultrasound 15, shown using the ultrasonic behavioral observation result of product coupling gel of the present invention, clear image,
It is stable, with control group without significant difference.Sampling is observed for 24 hours through culture, before and after product coupling gel group probe use of the present invention
There were significant differences, and using front and rear without significant difference in control group.
Its result see the table below：
Discussion and conclusion：
It is in test it was found that all relatively good through bacterium inspection situation of being popped one's head in during site of puncture ultrasound, through inquiring about ultrasound technician,
It is because preventing site of puncture from infecting, has carried out disinfectant measure in advance.
The above results show that coupling gel of the present invention is a kind of preferable ultrasound coupling gel.Coupling performance is good, clear picture
It is clear；Greasy property is good, easy to use；It is corrosion-free, to not damaged of popping one's head in；It is non-stimulated, without allergy, pollution-free, easy-clear, can inhale
Receive.Coupling gel of the present invention is different from common medical supersonic coupling gel, and it is added with composite bactericidal disinfection composition, can diagnosed
Killed in checking process and suppress the intersection sense between each bacterium such as pathogenicity gram- bacteria, fungi caused by probe and human contact
Dye and propagation；It is effective to ensure doctors and patients' health.
, also can be as listed by following table (total amount 50kg) when being produced in batches for each component dosage in specific implementation：
In above-mentioned list, each group forms according to a certain ratio, wherein the addition of carbomer carbomer, glycerine, triethanolamine, also
Lubrication can be played, is easy to remove, do not pollute, can absorb.
Finally it should be noted that：Above example only not limits technology described in the invention to illustrate the present invention
Scheme；Therefore, although this specification with reference to above-mentioned each embodiment to present invention has been detailed description, this
Field it is to be appreciated by one skilled in the art that still can be modified to the present invention or equivalent substitution；And all do not depart from this
The technical scheme of the spirit and scope of invention and its improvement, it all should cover in scope of the presently claimed invention.
Claims (6)
1. a kind of novel cavity channel ultrasound gel for possessing bactericidal action and preparation method thereof, including chitosan, trichlorine hydroxyl two
Phenylate, chlorhexidine acetate, polyoxyethylene sorbitan monoleate, carbomer, glycerine, triethanolamine, purified water.It is characterized in that：The matter of each composition
Measuring percentage is：Chitosan 0.1~2%, Triclosan 0.01~2%, chlorhexidine acetate 0.01~1%, poly- sorb
Ester 80 0.1~2%, carbomer 5~30%.Glycerine 0.1~5%, triethanolamine 0.5~3%, purified water 55~90%.
2. a kind of novel cavity channel ultrasound gel for possessing bactericidal action as claimed in claim 1 and preparation method thereof, it is special
Sign is：The present invention can continue to use the convenience of existing coupling gel, moreover it is possible to reach clear image；Greasy property is good；To probe
Corrosion-free damage；It is non-stimulated to skin and mucosa, without allergy, it is absorbable the advantages that；
3. a kind of novel cavity channel ultrasound gel for possessing bactericidal action as claimed in claim 1 and preparation method thereof, it is special
Sign is：Viscosity (25 DEG C) is not less than 15Pas in main performance；PH value 5.5~8.0；
4. a kind of novel cavity channel ultrasound gel for possessing bactericidal action as claimed in claim 1 and preparation method thereof, it is special
Sign is：It can be killed during ultrasonic diagnosis and suppress probe and gram- bacteria, fecal coliform caused by human contact
Fall, Pseudomonas aeruginosa, cross-infection and the propagation such as fungi；
5. a kind of novel cavity channel ultrasound gel for possessing bactericidal action as claimed in claim 1 and preparation method thereof, it is special
Sign is：It is clinically used for Vagina supersonic inspection, non-intact skin examination, proctoscopy, cystoscopy, examination by centesis, height
Danger crowd, severe infection patient check, all ultrasonic examinations in intensive care unit；Other all ultrasonic examinations can be safer；
6. a kind of novel cavity channel ultrasound gel for possessing bactericidal action as claimed in claim 1 and preparation method thereof, it is special
Sign is：Preparation process is as follows：
Step 1, chitosan 1g, Triclosan 0.1g, chlorhexidine acetate 0.1g are taken by weight, add polyoxyethylene sorbitan monoleate
Common 1g, purified water 100g is added, be well mixed；
Step 2, weigh carbomer 50g first add 300g purifying it is water-swellable, add the above-mentioned mixed solution prepared；
Step 3, after the solution is stirred, glycerine, triethanolamine are added, adjust viscosity and PH, make viscosity (25 DEG C) no
Less than 15Pas；PH value 5.5~8.0；1000g is settled to purified water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610528765.1A CN107537043A (en) | 2016-06-28 | 2016-06-28 | A kind of novel cavity channel ultrasound gel for possessing bactericidal action and preparation method thereof |
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|---|---|---|---|
| CN201610528765.1A CN107537043A (en) | 2016-06-28 | 2016-06-28 | A kind of novel cavity channel ultrasound gel for possessing bactericidal action and preparation method thereof |
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| CN107537043A true CN107537043A (en) | 2018-01-05 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109289095A (en) * | 2018-11-23 | 2019-02-01 | 淮海工学院 | A kind of colonoscopy gelling agent of saliferous lidocaine hydrochloride and preparation method thereof |
| CN113975414A (en) * | 2021-11-02 | 2022-01-28 | 安徽深蓝医疗科技股份有限公司 | Disinfection and sterilization coupling agent and preparation method thereof |
-
2016
- 2016-06-28 CN CN201610528765.1A patent/CN107537043A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109289095A (en) * | 2018-11-23 | 2019-02-01 | 淮海工学院 | A kind of colonoscopy gelling agent of saliferous lidocaine hydrochloride and preparation method thereof |
| CN109289095B (en) * | 2018-11-23 | 2021-03-26 | 淮海工学院 | Enteroscope gel containing lidocaine hydrochloride and preparation method thereof |
| CN113975414A (en) * | 2021-11-02 | 2022-01-28 | 安徽深蓝医疗科技股份有限公司 | Disinfection and sterilization coupling agent and preparation method thereof |
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Legal Events
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| PB01 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180105 |