CN103100090A - Hard capsule shell material and production process thereof - Google Patents
Hard capsule shell material and production process thereof Download PDFInfo
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- CN103100090A CN103100090A CN2013100194021A CN201310019402A CN103100090A CN 103100090 A CN103100090 A CN 103100090A CN 2013100194021 A CN2013100194021 A CN 2013100194021A CN 201310019402 A CN201310019402 A CN 201310019402A CN 103100090 A CN103100090 A CN 103100090A
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Abstract
The invention belongs to the technical field of research and development of medicines and health food products and relates to a hard capsule shell material and a production process thereof. The production process is characterized by comprising the steps of: weighing 9.0-12.0wt% of sodium alginate, 2.0-5.0wt% of flaxseed gum or guar gum, 2.0-3.0wt% of CaCO3, 2.0-4.0wt% of NaHCO3 and 2.0-4.0wt% of a plasticizer, putting the materials into a mixed solution of 70-80.0wt% of distilled water and 2.0-4.0wt% of coconut oil, and carrying out gum dissolving, heat preserving, immersed gum forming, drying, shell picking, cutting, finishing, packaging and the like on the mixture, so as to obtain the hard capsule shell material. The hard capsule shell material is reasonable in formula, safe to eat, beneficial to medicine absorption, wide in raw material source, low in price, simple in production process and suitable for industrial production.
Description
Technical field:
The present invention relates to health food and pharmaceutical capsule, particularly a kind of method of producing medical capsule shells with sodium alginate.
Background technology:
At present, the primary raw material that China produces empty hard capsule is gelatin, and gelatin derives from bone and the skin of animal (pig, cattle), and its main component is protein.
Along with the understanding of people to plant capsule, and the transformation of public's medication theory both at home and abroad, the market demand of plant capsule is increased rapidly.Because plant capsule does not use any gelatin, numerous Moslems patient can take in relieved powder charge simultaneously, and product can export to vast Islam and kosher is regional, will earn foreign exchange for country, has improved the economic benefit of enterprise.
Sodium alginate is a kind of polysaccharide carbohydrate that extracts from the Thallus Laminariae (Thallus Eckloniae) of Brown algae or Alga Sgrgassi Enerves, by relying on 1 by α-L-mannuronic acid (M unit) and β-D-guluronic acid (G unit), the copolymer that the 4-glycosidic bond connects and is comprised of GM, MM and the GG fragment of different proportion, a kind of in the alginic acid derivant, so sometimes also claim sodium alginate or seaweed gel and alginate jelly.Sodium alginate is with its good biological degradability and biocompatibility, and is widely used in the fields such as chemistry, biology, medicine, food.
Summary of the invention:
The object of the present invention is to provide a kind of with sodium alginate production have that extensibility, tension force are strong, the toughness method of medical capsule shells preferably.
The technical solution adopted for the present invention to solve the technical problems is: the film forming raw material of capsule shells contains major ingredient and multiple auxiliary materials mixture, and major ingredient contains sodium alginate, Semen Lini glue or guar gum, and adjuvant contains Oleum Cocois, CaCO
3, NaHCO
3, plasticizer, water, also can additionally increase certain additive according to product needed, as antiseptic, aromatic and coloring agent etc.
1, the formula of the present invention's sodium alginate capsule shells following (following all by weight percentage):
Hydrophilic gel: 12.0% sodium alginate, Semen Lini glue or guar gum,
Flocculation aid: 2.0% CaCO
3, 2.0% NaHCO
3,
Correctives, screening agent: 2.0% Oleum Cocois
Plasticizer: sorbitol or xylitol
Water content 13-15% in product
2, the production technology of the present invention's sodium alginate capsule shells is carried out in accordance with the following steps:
(1) colloidal sol, insulation:
Pure water and Oleum Cocois mixed and be heated to 60-80 ℃, slowly the pressed powder that weighs up is added under constantly stirring until forms clear solution, then in the dislocation interlayer steam cooker, heating 20min at 80 ℃, making it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 60-90min, naturally remove the foam on liquid level, make the glue clarification standby.
(2) dip in gum forming, drying:
Pour glue into the 30min that circulates in the glue groove, dip in glue when observing the glue surface without bubble.Use capsule die, tringle is immersed dip in glue capsule blank in glue.The tringle of first choosing suitable specification is fixed on template, with appropriate lubrication of liquid paraffin.Tringle is steadily held, the upper end is immersed downwards in glue, treat approximately 6-8s of the whole submergence tringles of glue, namely slowly template is mentioned, leave glue liquid surface, then template is dug, upset makes cooling for several times, dips in the speed of glue and generally is advisable with 5-6 plate/min.Utilize the hot and cold air drying that flows, room temperature should keep 45-55 ℃, relative humidity 30-40%, and the flow velocity of hot-air is about 12-15m/s, and general 60min gets final product.
(3) pull out shell, cut:
The softgel shell of oven dry is pulled up to get rough blank with pulling out the glue device, rough blank is sent between cutting, cut into early-products according to the model of capsule.
(4) arrange, pack:
Substandard products, waste product in capsule under cutting are chosen picked.Capsule two is saved fits up and down, and splendid attire is stored in shady and cool dry place in hermetic container, be finished product after packing.
Specific embodiments:
The preparation technology of a kind of sodium alginate capsule shells of the present invention comprises following examples, and the following examples can further illustrate the present invention, but do not limit the present invention in any way.
The formula for a product (consisting of by weight percentage) of embodiment 1, the present invention's sodium alginate capsule: 12.0% sodium alginate, 4.0% Semen Lini glue, 2.0% CaCO
3, 2.0% NaHCO
3, 3.0% sorbitol, 75.0% distilled water and 2.0% Oleum Cocois; The capsule fabrication processing is: the distilled water with 75.0% mixes with 2.0% Oleum Cocois and is heated to 75 ℃, 12.0% the sodium alginate that slowly will weigh up under constantly stirring, 4.0% Semen Lini glue, 3.0% sorbitol, 2.0% CaCO
3, 2.0% NaHCO
3Add until form clear solution, in rear dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 80min, naturally remove the foam on liquid level.The glue of resting is poured the 30min that circulates in the glue groove into, automatically dips in glue, drying, pulls out shell, namely gets product of the present invention after cutting, arrangement, packaging and other steps through the capsule shells mould.
The formula for a product (consisting of by weight percentage) of embodiment 2, the present invention's sodium alginate capsule: 11.0% sodium alginate, 3.0% guar gum, 2.0% CaCO
3, 3.5% NaHCO
3, 2.5% xylitol, 75.0% distilled water and 3.0% Oleum Cocois; The capsule fabrication processing is: the distilled water with 75.0% mixes with 3.0% Oleum Cocois and is heated to 80 ℃, 11.0% the sodium alginate that slowly will weigh up under constantly stirring, 3.0% guar gum, 2.5% xylitol, 2.0% CaCO
3, 3.5% NaHCO
3Add until form clear solution, in rear dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 85min, naturally remove the foam on liquid level.The glue of resting is poured the 30min that circulates in the glue groove into, automatically dips in glue, drying, pulls out shell, namely gets product of the present invention after cutting, arrangement, packaging and other steps through the capsule shells mould.
Claims (6)
1. a hard capsule capsule casing material and production technology thereof, it is characterized in that: its composition of raw materials and weight proportion are: sodium alginate accounts for 9.0-12.0%, one or both in Semen Lini glue and guar gum account for 2.0-5.0%, CaCO3 accounts for 2.0-3.0%, NaHCO3 accounts for 2.0-4.0%, one or both in sorbitol and xylitol account for 2.0-4.0%, put into the Oleum Cocois mixed solution of distilled water and the 2.0-4.0% of 70.0-80.0%, its processing step is: after feeding intake by above-mentioned formula and weight proportion, through colloidal sol, insulation, dip in gum forming, dry, pull out shell, cutting, arrange, get final product after packing.
2. hard capsule softgel shell production method described according to claims 1, it is characterized in that: described colloidal sol, incubation step are for to mix pure water and Oleum Cocois and be heated to 60-80 ℃, slowly the pressed powder that weighs up is added until form clear solution under constantly stirring, then in the dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue, use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 60-90min, naturally remove the foam on liquid level, make the glue clarification standby.
3. hard capsule softgel shell production method described according to claims 1 or 2, it is characterized in that: describedly dip in gum forming, drying steps is: first glue is poured into the 30min that circulates in the glue groove, dip in glue when observing the glue surface without bubble, and blank was positioned in 50 ℃, the baking oven of relative humidity 30-40% oven dry 1 hour.
4. hard capsule softgel shell production method described according to claims 3 is characterized in that: describedly pull out shell, cutting step is: the softgel shell of oven dry is pulled up to get rough blank with pulling out the glue device, rough blank is sent between cutting, cut into early-products according to the model of capsule.
5. root is dug the described hard capsule softgel shell of claims 4 production method, and it is characterized in that: described arrangement, packaging step are: the substandard products in the capsule under cutting, waste product are chosen and are picked.Capsule two is saved fits up and down, and splendid attire is stored in shady and cool dry place in hermetic container, be finished product after packing.
6. hard capsule softgel shell production method described according to claims 5 is characterized in that: described batching, colloidal sol, be incubated, dip in gum forming, drying, pull out shell, cutting, arrangement, packing should carry out in 300,000 grades of clean rooms.
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CN2013100194021A CN103100090A (en) | 2013-01-04 | 2013-01-04 | Hard capsule shell material and production process thereof |
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CN2013100194021A CN103100090A (en) | 2013-01-04 | 2013-01-04 | Hard capsule shell material and production process thereof |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103877587A (en) * | 2014-04-11 | 2014-06-25 | 江苏省海洋资源开发研究院(连云港) | Plant polysaccharide medicinal enteric hard-shell capsule and preparation method thereof |
CN104338146A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and bottle gourd Pakistan rubber as capsule wall material, and its production technology |
CN104338144A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
CN104338140A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and sa-son seed gum as capsule wall material, and its production technology |
CN104338143A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and methyl cellulose as capsule wall material, and its production technology |
CN104338141A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and konjac glucomannan as capsule wall material, and its production technology |
CN106675057A (en) * | 2017-03-02 | 2017-05-17 | 重庆交通大学 | Preparation method of hard-shell calcium alginate oil sac |
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CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
CN102078311A (en) * | 2010-12-21 | 2011-06-01 | 中国海洋大学 | Method for preparing marine plant alginate polysaccharide enteric coated hard capsules |
CN102133207A (en) * | 2011-03-15 | 2011-07-27 | 温州医学院 | Novel capsule colon-specific drug delivery system (CSDDS) and preparation method thereof |
CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
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2013
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
CN102078311A (en) * | 2010-12-21 | 2011-06-01 | 中国海洋大学 | Method for preparing marine plant alginate polysaccharide enteric coated hard capsules |
CN102133207A (en) * | 2011-03-15 | 2011-07-27 | 温州医学院 | Novel capsule colon-specific drug delivery system (CSDDS) and preparation method thereof |
CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104338146A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and bottle gourd Pakistan rubber as capsule wall material, and its production technology |
CN104338144A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
CN104338140A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and sa-son seed gum as capsule wall material, and its production technology |
CN104338143A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and methyl cellulose as capsule wall material, and its production technology |
CN104338141A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and konjac glucomannan as capsule wall material, and its production technology |
CN103877587A (en) * | 2014-04-11 | 2014-06-25 | 江苏省海洋资源开发研究院(连云港) | Plant polysaccharide medicinal enteric hard-shell capsule and preparation method thereof |
CN103877587B (en) * | 2014-04-11 | 2016-01-20 | 江苏省海洋资源开发研究院(连云港) | Medicinal enteric hard-shell capsule of a kind of vegetable polysaccharides and preparation method thereof |
CN106675057A (en) * | 2017-03-02 | 2017-05-17 | 重庆交通大学 | Preparation method of hard-shell calcium alginate oil sac |
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Application publication date: 20130515 |