CN104338142A - Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology - Google Patents
Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology Download PDFInfo
- Publication number
- CN104338142A CN104338142A CN201310327110.4A CN201310327110A CN104338142A CN 104338142 A CN104338142 A CN 104338142A CN 201310327110 A CN201310327110 A CN 201310327110A CN 104338142 A CN104338142 A CN 104338142A
- Authority
- CN
- China
- Prior art keywords
- drop pill
- pill
- dropping
- sargassum polysaccharides
- glue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of medicine and health food products research and development, and relates to a formula and a production technology of a dropping pill based on algal polysaccharide. The technology comprises the following steps: 1, weighing 10.0-30.0wt% of algal polysaccharide, 3.0-10.0wt% of flaxseed gum and 2.0-4.0wt% of a plasticizer, putting the above raw materials in 70.0-85.0wt% of deionized water, and maintaining at 85DEG C for 30min to realize algal polysaccharide and flaxseed gum dissolving; 2, degassing at 85DEG C under 0.5atm for 10min, adding the obtained degassed solution into a pill dropping machine, and dropping; and 3, curing dropping pills by a composite curing agent, drying, sorting, and packaging to obtain the dropping pill. The dropping pill has the advantages of reasonable formula, safe eating, drug absorption benefiting, wide source and low price of the raw materials, simple production process, and suitableness for industrialized production.
Description
Technical field
The present invention relates to health food and pharmaceutical capsule, particularly a kind of Sargassum polysaccharides produces the method for medicinal drop pill.
Background technology
At present, the primary raw material that China produces drop pill is gelatin, and gelatin derives from bone and the skin of animal (pig, cattle), and its main component is protein.Once production management is not in place, just may there is the risk of affecting animals source disease, heavy metal etc. in this capsule shell.Numerous religious believers, Buddhism lay Buddhist and vegetarian cannot accept the capsule class medicine from animal.In addition because gelatin belongs to protein matter, hygroscopicity is strong, and can, the water transport absorbed to internal drug, the medicine moisture absorption be gone bad, and causes off quality short with effect duration.
Along with people are to the understanding of plant capsule, and the transformation of domestic and international public's medication theory, the market demand of plant origin capsule will be made to increase rapidly.Simultaneously because plant capsule does not use any gelatin, numerous Moslems patient can take in relieved powder charge, and product can export to vast Islam and kosher area, will earn foreign exchange, and improve the economic benefit of enterprise for country.
Sargassum polysaccharides (sodium alginate) is a kind of polysaccharide carbohydrate extracted from the Thallus Laminariae (Thallus Eckloniae) or Alga Sgrgassi Enerves of Brown algae, rely on 1 by α-L-mannuronic acid (M unit) and β-D-guluronic acid (G unit), 4-glycosidic bond connects and the copolymer be made up of GM, MM and GG fragment of different proportion, the one in alginic acid derivative, so sometimes also claim sodium alginate or seaweed gel and alginate jelly.Sargassum polysaccharides with its good biological degradability and biocompatibility, and is widely used in the fields such as chemistry, biology, medicine, food.
Summary of the invention
The object of the present invention is to provide a kind of Sargassum polysaccharides to produce to have that extensibility, tension force are strong, the method for the good medicinal drop pill of toughness.
The technical solution adopted for the present invention to solve the technical problems is: the film forming raw material of drop pill contains major ingredient and multiple auxiliary materials mixture, major ingredient contains Sargassum polysaccharides, flax glue contains plasticizer, water, also can additionally increase certain additive according to product needed, as antiseptic, aromatic and coloring agent etc.
1, the formula following (below all by weight percentage) of the Sargassum polysaccharides drop pill shell of the present invention:
Hydrophilic gel: the sodium alginate of 20.0%, the flax glue of 6.0%
Correctives, screening agent: the bourbonal,ethyl vanillin of 0.1%, the titanium dioxide of 0.2%
Plasticizer: glycerol, sorbitol or xylitol
Water content 13-25% in product
2, the production technology of the Sargassum polysaccharides drop pill shell of the present invention is carried out in accordance with the following steps:
(1) colloidal sol, insulation:
Pure water and plasticizer mixed and is heated to 80 DEG C, slowly the pressed powder weighed up being added until form clear solution under constantly stirring, then in dislocation interlayer steam cooker, at 85 DEG C of heating 20min, making it to dissolve uniformly glue.Use filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot again, degassed standing 10min under 0.5atm at 85 DEG C, makes glue clarify for subsequent use.
(2) dripping, solidification:
Glue is poured in the glue groove of drop pill experiment dripping machine, keep 85 DEG C.Setting firming agent temperature is 15 ~ 20 DEG C, and the velocity ratio of glue and medicinal liquid is between 1:2 ~ 4, and controls total flow.Enable soft gelatin capsule smoothly by firming agent interface and adhesion.Drop pill hardening time in lower floor's firming agent is 1 ~ 10 minute.
(3) dry, arrangement:
The drop pill solidified is positioned over 50 DEG C, dries 3 ~ 4 hours in the climatic chamber of relative humidity 30-50%.Substandard products in capsule after oven dry, waste product are chosen and picked.And by capsule splendid attire in hermetic container, constant humidity is stored in shady and cool dry place, is finished product after packaging.
specific embodiments:
The preparation technology of a kind of Sargassum polysaccharides drop pill of the present invention comprises following examples, and the following examples can further illustrate the present invention, but do not limit the present invention in any way.
embodiment 1, the present invention the formula for a product (consisting of by weight percentage) of Sargassum polysaccharides drop pill: the sodium alginate of 20.0%, the agar of 6.0%, 8.0% sorbitol and glycerol, the distilled water of 65.0% and the auxiliary agent of 1%; Drop pill fabrication processing is: mixed with the plasticizer of 8.0% by the distilled water of 65.0% and be heated to 85 DEG C, slowly the epoxy glue of the sodium alginate of weigh up 20.0%, the agar of 6.0% is added until form clear solution under constantly stirring, in rear dislocation interlayer steam cooker, at 85 DEG C of heating 20min, make it to dissolve uniformly glue.Using filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot again, under 85 DEG C of 0.5 atm after degassed 10min, naturally removing the foam on liquid level.Poured into by the glue configured in the glue groove of drop pill experiment dripping machine, setting firming agent temperature is 15 ~ 20 DEG C, and the velocity ratio of glue and medicinal liquid is between 1:2 ~ 4, and controls total flow and carry out dripping.The drop pill solidified is positioned over 50 DEG C, dries 1 hour in the climatic chamber of relative humidity 30-40%.Substandard products in capsule after oven dry, waste product are chosen and picked.And by capsule splendid attire in hermetic container, constant humidity is stored in shady and cool dry place, namely obtains product of the present invention after packaging.
embodiment 2, the present invention the formula for a product (consisting of by weight percentage) of Sargassum polysaccharides capsule: the sodium alginate of 16.0%, the flax glue of 8.0%, the xylitol of 8%, the distilled water of 67% and 1% auxiliary agent; Capsule fabrication processing is: mixed with the plasticizer of 8% by the distilled water of 67% and be heated to 85 DEG C, slowly the mixture of the sodium alginate of weigh up 16.0%, the flax glue of 8.0% is added until form clear solution under constantly stirring, in rear dislocation interlayer steam cooker, at 85 DEG C of heating 20min, make it to dissolve uniformly glue.Using filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot again, under 85 DEG C of 0.5 atm after degassed 10min, naturally removing the foam on liquid level.Poured into by the glue configured in the glue groove of drop pill experiment dripping machine, setting firming agent temperature is 15 ~ 20 DEG C, and the velocity ratio of glue and medicinal liquid is between 1:2 ~ 4, and controls total flow and carry out dripping.The drop pill solidified is positioned over 50 DEG C, dries 1 hour in the climatic chamber of relative humidity 30-50%.Substandard products in capsule after oven dry, waste product are chosen and picked.And by capsule splendid attire in hermetic container, constant humidity is stored in shady and cool dry place, namely obtains product of the present invention after packaging.
Claims (5)
1. a Sargassum polysaccharides drop pill, it is characterized in that: take Sargassum polysaccharides (sodium alginate), the flax glue of 3.0-10.0%, the plasticizer of 2.0-4.0% that percentage by weight is 10.0-30.0%, put into the deionized water of 70.0-85.0%, keep carrying out colloidal sol in 30 minutes at 85 DEG C; Under 85 DEG C of 0.5atm degassed 10 minutes, then add pill dripping machine and carry out dripping; Drop pill composite curing agent is cured, then dry, arrange, after packaging and other steps and get final product.
2. the Sargassum polysaccharides drop pill production method according to claims 1, it is characterized in that: described colloidal sol, incubation step are for heat 80 DEG C by pure water and plasticizer, slowly the pressed powder weighed up is added until form clear solution under constantly stirring, then in dislocation interlayer steam cooker, at 85 DEG C of heating 30min, make it to dissolve uniformly glue, then use filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot, under 85 DEG C of 0.5atm degassed 10 minutes; Then add pill dripping machine and carry out dripping, drop pill composite curing agent is cured, dry, arrangement.
3. the Sargassum polysaccharides drop pill production method according to claims 2, is characterized in that: be positioned over 50 DEG C through the drop pill of overcuring, dry 3 ~ 4 hours in the baking oven of relative humidity 30-50%.
4. the Sargassum polysaccharides drop pill production method according to claims 2, it is characterized in that: described composite curing agent solidification: firming agent is made up of two parts, top is organic facies, for by but be not limited to vegetable oil, paraffin oil, methyl-silicone oil form, bottom for by but be not limited to Ca
2+, Mg
2+, Al
3+, Zn
2+deng the curing agent solution of cation composition, total concentration is 1.5 ~ 4.5%.
5. the Sargassum polysaccharides drop pill production method according to claims 2, is characterized in that: described batching, colloidal sol, insulation, solidification, drying, arrangement, packaging should be carried out in 300,000 grades of clean rooms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310327110.4A CN104338142A (en) | 2013-07-31 | 2013-07-31 | Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310327110.4A CN104338142A (en) | 2013-07-31 | 2013-07-31 | Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104338142A true CN104338142A (en) | 2015-02-11 |
Family
ID=52495129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310327110.4A Pending CN104338142A (en) | 2013-07-31 | 2013-07-31 | Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104338142A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440124A (en) * | 2017-10-11 | 2017-12-08 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material |
| CN107485026A (en) * | 2017-10-11 | 2017-12-19 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the enhancing memory soft capsule preparation of capsule material |
| CN107495375A (en) * | 2017-10-11 | 2017-12-22 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the preventing and treating cardiovascular and cerebrovascular disease soft capsule preparation of capsule material |
| CN107495376A (en) * | 2017-10-11 | 2017-12-22 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the antifatigue soft capsule preparation of capsule material |
| CN107594526A (en) * | 2017-10-11 | 2018-01-19 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the aid digestion soft capsule preparation of capsule material |
| CN107660797A (en) * | 2017-10-11 | 2018-02-06 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the anti-aging soft capsule preparation of capsule material |
| CN107712894A (en) * | 2017-10-18 | 2018-02-23 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material |
-
2013
- 2013-07-31 CN CN201310327110.4A patent/CN104338142A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440124A (en) * | 2017-10-11 | 2017-12-08 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material |
| CN107485026A (en) * | 2017-10-11 | 2017-12-19 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the enhancing memory soft capsule preparation of capsule material |
| CN107495375A (en) * | 2017-10-11 | 2017-12-22 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the preventing and treating cardiovascular and cerebrovascular disease soft capsule preparation of capsule material |
| CN107495376A (en) * | 2017-10-11 | 2017-12-22 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the antifatigue soft capsule preparation of capsule material |
| CN107594526A (en) * | 2017-10-11 | 2018-01-19 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the aid digestion soft capsule preparation of capsule material |
| CN107660797A (en) * | 2017-10-11 | 2018-02-06 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the anti-aging soft capsule preparation of capsule material |
| CN107712894A (en) * | 2017-10-18 | 2018-02-23 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104338142A (en) | Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology | |
| CN104337779A (en) | Dropping pill with seaweed gel and agar as capsule wall material, and its production technology | |
| CN104886554B (en) | Quick-fried pearl soft capsule and preparation method thereof | |
| CN103301086B (en) | Plant cellulose hard empty capsule preparation method | |
| CN104721170B (en) | A kind of epoxy glue masticatory pattern soft capsule and preparation method thereof | |
| CN106166143B (en) | Plant hard hollow capsule shell and preparation method thereof | |
| CN111454490B (en) | Composition for preparing edible plant plasma membrane and application thereof | |
| CN101336905A (en) | Production method of alpha-linolenic acid microcapsule | |
| CN103100090A (en) | Hard capsule shell material and production process thereof | |
| CN105878208B (en) | A kind of starch base plant medicinal hard capsule forming agent and its application | |
| CN103100091A (en) | Compound seaweed gum and application thereof to capsule preparation | |
| CN105456226B (en) | Hydroxypropyl methyl cellulose/hydroxypropul starch plant hollow capsule and preparation method | |
| CN105148322B (en) | Injection aquagel and preparation method thereof | |
| CN102895215A (en) | Cellulose and red alga polysaccharide plant empty capsule and raw material composition and preparation method thereof | |
| CN103127519A (en) | Sea-tangle glue capsule membrane material and manufacturing process thereof | |
| CN103006616A (en) | Algal polysaccharide capsules and method for manufacturing same | |
| CN102816347B (en) | Botanical hollow capsule, and preparation technology and preparation system thereof | |
| CN104338145A (en) | Dropping pill with sodium alginate and gellan gum as capsule wall material, and its production technology | |
| CN103417510B (en) | Tamarind gum plant capsule and preparation method thereof | |
| CN104338140A (en) | Dropping pill with sodium alginate and sa-son seed gum as capsule wall material, and its production technology | |
| CN104338144A (en) | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology | |
| CN104523832B (en) | A kind of preparation method of compound Danshen Root thin membrane coated tablet | |
| CN103041397A (en) | Sodium alga acid capsule and production process thereof | |
| CN103919119B (en) | Double glue Ganoderma spore powder with cellular wall broken of a kind of antioxidative and preparation method thereof | |
| CN104337781A (en) | Dropping pill with sodium alginate and xanthan gum as capsule wall material, and its production technology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150211 |
|
| WD01 | Invention patent application deemed withdrawn after publication |