CN103100091A - Compound seaweed gum and application thereof to capsule preparation - Google Patents
Compound seaweed gum and application thereof to capsule preparation Download PDFInfo
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- CN103100091A CN103100091A CN2013100194229A CN201310019422A CN103100091A CN 103100091 A CN103100091 A CN 103100091A CN 2013100194229 A CN2013100194229 A CN 2013100194229A CN 201310019422 A CN201310019422 A CN 201310019422A CN 103100091 A CN103100091 A CN 103100091A
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Abstract
The invention belongs to the technical field of research and development of medicines and health food products and relates to compound seaweed gum and an application thereof to capsule preparation. The compound seaweed gum is prepared by the following steps of: weighing 9.0-12.0wt% of sodium alginate, 1.0-5.0wt% of xanthan gum, 2.0-4.0wt% of CaCO3, 2.0-5.0wt% of NaHCO3 and 2.0-4.0wt% of a plasticizer, putting the materials into a mixed solution of 75.0-80.0wt% of distilled water and 1.0-6.0wt% of coconut oil and carrying out gum dissolving, heat preserving, immersed gum forming, drying, shell picking, cutting, finishing, packaging and the like on the mixture. The compound seaweed gum is reasonable in formula, safe to eat, beneficial to medicine absorption, wide in raw material source, low in price and simple in production process and is suitable for industrial production.
Description
Technical field:
The present invention relates to health food and pharmaceutical capsule, particularly a kind of method of producing medical capsule shells with sodium alginate.
Background technology:
At present, the primary raw material that China produces empty hard capsule is gelatin, and gelatin derives from bone and the skin of animal (pig, cattle), and its main component is protein.
Along with the understanding of people to plant capsule, and the transformation of public's medication theory both at home and abroad, the market demand of plant capsule is increased rapidly.Because plant capsule does not use any gelatin, numerous Moslems patient can take in relieved powder charge simultaneously, and product can export to vast Islam and kosher is regional, will earn foreign exchange for country, has improved the economic benefit of enterprise.
Sodium alginate is a kind of polysaccharide carbohydrate that extracts from the Thallus Laminariae (Thallus Eckloniae) of Brown algae or Alga Sgrgassi Enerves, by relying on 1 by α-L-mannuronic acid (M unit) and β-D-guluronic acid (G unit), the copolymer that the 4-glycosidic bond connects and is comprised of GM, MM and the GG fragment of different proportion, a kind of in the alginic acid derivant, so sometimes also claim sodium alginate or seaweed gel and alginate jelly.Sodium alginate is with its good biological degradability and biocompatibility, and is widely used in the fields such as chemistry, biology, medicine, food.
Summary of the invention:
The object of the present invention is to provide a kind of with sodium alginate production have that extensibility, tension force are strong, the toughness method of medical capsule shells preferably.
The technical solution adopted for the present invention to solve the technical problems is: the film forming raw material of capsule shells contains major ingredient and multiple auxiliary materials mixture, and major ingredient contains sodium alginate, xanthan gum, and adjuvant contains Oleum Cocois, CaCO
3, NaHCO
3, plasticizer, water, also can additionally increase certain additive according to product needed, as antiseptic, aromatic and coloring agent etc.
1, the formula of the present invention's sodium alginate capsule shells following (following all by weight percentage):
Hydrophilic gel: 10.0% sodium alginate, 4.0% xanthan gum,
Flocculation aid: 2.0% CaCO
3, 4.0% NaHCO
3,
Correctives, screening agent: 2.0% Oleum Cocois
Plasticizer: sorbitol or glycerol
Water content 13-15% in product
2, the production technology of the present invention's sodium alginate capsule shells is carried out in accordance with the following steps:
(1) colloidal sol, insulation:
Pure water and Oleum Cocois mixed and be heated to 60-80 ℃, slowly the pressed powder that weighs up is added under constantly stirring until forms clear solution, then in the dislocation interlayer steam cooker, heating 20min at 80 ℃, making it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 60-90min, naturally remove the foam on liquid level, make the glue clarification standby.
(2) dip in gum forming, drying:
Pour glue into the 30min that circulates in the glue groove, dip in glue when observing the glue surface without bubble.Use capsule die, tringle is immersed dip in glue capsule blank in glue.The tringle of first choosing suitable specification is fixed on template, with appropriate lubrication of liquid paraffin.Tringle is steadily held, the upper end is immersed downwards in glue, treat approximately 6-8s of the whole submergence tringles of glue, namely slowly template is mentioned, leave glue liquid surface, then template is dug, upset makes cooling for several times, dips in the speed of glue and generally is advisable with 5-6 plate/min.Utilize the hot and cold air drying that flows, room temperature should keep 45-55 ℃, relative humidity 30-40%, and the flow velocity of hot-air is about 12-15m/s, and general 60min gets final product.
(3) pull out shell, cut:
The softgel shell of oven dry is pulled up to get rough blank with pulling out the glue device, rough blank is sent between cutting, cut into early-products according to the model of capsule.
(4) arrange, pack:
Substandard products, waste product in capsule under cutting are chosen picked.Capsule two is saved fits up and down, and splendid attire is stored in shady and cool dry place in hermetic container, be finished product after packing.
Specific embodiments:
The preparation technology of a kind of sodium alginate capsule shells of the present invention comprises following examples, and the following examples can further illustrate the present invention, but do not limit the present invention in any way.
The formula for a product (consisting of by weight percentage) of embodiment 1, the present invention's sodium alginate capsule: 10.0% sodium alginate, 4.0% xanthan gum, 2.0% CaCO
3, 4.0% NaHCO
3, 3.0% sorbitol, 75.0% distilled water and 2.0% Oleum Cocois; The capsule fabrication processing is: the distilled water with 75.0% mixes with 2.0% Oleum Cocois and is heated to 75 ℃, 10.0% the sodium alginate that slowly will weigh up under constantly stirring, 4.0% xanthan gum, 3.0% sorbitol, 2.0% CaCO
3, 4.0% NaHCO
3Add until form clear solution, in rear dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 80min, naturally remove the foam on liquid level.The glue of resting is poured the 30min that circulates in the glue groove into, automatically dips in glue, drying, pulls out shell, namely gets product of the present invention after cutting, arrangement, packaging and other steps through the capsule shells mould.
The formula for a product (consisting of by weight percentage) of embodiment 2, the present invention's sodium alginate capsule: 11.0% sodium alginate, 5.0% xanthan gum, 1.5% CaCO
3, 2.5% NaHCO
3, 3.0% glycerol, 75.0% distilled water and 2.0% Oleum Cocois; The capsule fabrication processing is: the distilled water with 75% and 3.0% glycerol, 2.0% Oleum Cocois mix and are heated to 80 ℃, 11.0% the sodium alginate that slowly will weigh up under constantly stirring, 5.0% xanthan gum, 1.5% CaCO
3, 2.5% NaHCO
3Add until form clear solution, in rear dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 85min, naturally remove the foam on liquid level.The glue of resting is poured the 30min that circulates in the glue groove into, automatically dips in glue, drying, pulls out shell, namely gets product of the present invention after cutting, arrangement, packaging and other steps through the capsule shells mould.
Claims (6)
1. a composite seaweed gel and the application in the capsule preparation thereof, it is characterized in that: its composition of raw materials and weight proportion are: sodium alginate accounts for 9.0-12.0%, xanthan gum accounts for 1.0-5.0%, CaCO
3Account for 2.0-4.0%, NaHCO
3Account for one or both in 2.0-5.0%, sorbitol and glycerol and account for 1.0-6.0%, put into the Oleum Cocois mixed solution of distilled water and the 2.0-6.0% of 75.0-80.0%, its processing step is: after feeding intake by above-mentioned formula and weight proportion, through colloidal sol, be incubated, dip in gum forming, drying, pull out shell, get final product after cutting, arrangement, packing.
2. composite seaweed gel described according to claims 1, it is characterized in that: described colloidal sol, incubation step are for to mix pure water and Oleum Cocois and be heated to 60-80 ℃, slowly the pressed powder that weighs up is added until form clear solution under constantly stirring, then in the dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue, use again filter cloth (150 order) filter to enter to dip in glue pot (using water bath heat preservation), after 55 ℃ of standing 60-90min, naturally remove the foam on liquid level, make the glue clarification standby.
3. a kind of composite seaweed gel described according to claims 1 or 2 and the application in the capsule preparation thereof, it is characterized in that: describedly dip in gum forming, drying steps is: first glue is poured into the 30min that circulates in the glue groove, dip in glue when observing the glue surface without bubble, and blank was positioned in 50 ℃, the baking oven of relative humidity 30-40% oven dry 1 hour.
4. a kind of composite seaweed gel described according to claims 3 and the application in the capsule preparation thereof, it is characterized in that: describedly pull out shell, cutting step is: the softgel shell of oven dry is pulled up to get rough blank with pulling out the glue device, rough blank is sent between cutting, cut into early-products according to the model of capsule.
5. the root pick described a kind of composite seaweed gel of claims 4 and the application in the capsule preparation thereof, it is characterized in that: described arrangement, packaging step are: the substandard products in the capsule under cutting, waste product are chosen and are picked.Capsule two is saved fits up and down, and splendid attire is stored in shady and cool dry place in hermetic container, be finished product after packing.
6. a kind of composite seaweed gel described according to claims 5 and the application in capsule preparation thereof is characterized in that: described batching, colloidal sol, be incubated, dip in gum forming, drying, pull out shell, cutting, arrangement, packing should carry out in 300,000 grades of clean rooms.
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104224747A (en) * | 2014-09-09 | 2014-12-24 | 浙江万里学院 | Algae-based gastric pH response disintegrative empty capsule and preparation method thereof |
CN104274424A (en) * | 2014-09-05 | 2015-01-14 | 韩字光 | Plant empty capsule and manufacturing method thereof |
CN104337781A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and xanthan gum as capsule wall material, and its production technology |
CN104338144A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
CN104338143A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and methyl cellulose as capsule wall material, and its production technology |
CN109497052A (en) * | 2018-12-29 | 2019-03-22 | 青岛海大生物集团有限公司 | A kind of polysaccharide is used as the preparation process of agricultural-chemical suspension auxiliary agent |
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CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
CN102078311A (en) * | 2010-12-21 | 2011-06-01 | 中国海洋大学 | Method for preparing marine plant alginate polysaccharide enteric coated hard capsules |
CN102133207A (en) * | 2011-03-15 | 2011-07-27 | 温州医学院 | Novel capsule colon-specific drug delivery system (CSDDS) and preparation method thereof |
CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
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2013
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Patent Citations (5)
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CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
CN102078311A (en) * | 2010-12-21 | 2011-06-01 | 中国海洋大学 | Method for preparing marine plant alginate polysaccharide enteric coated hard capsules |
CN102133207A (en) * | 2011-03-15 | 2011-07-27 | 温州医学院 | Novel capsule colon-specific drug delivery system (CSDDS) and preparation method thereof |
CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104337781A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and xanthan gum as capsule wall material, and its production technology |
CN104338144A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
CN104338143A (en) * | 2013-07-31 | 2015-02-11 | 山东大学(威海) | Dropping pill with sodium alginate and methyl cellulose as capsule wall material, and its production technology |
CN104274424A (en) * | 2014-09-05 | 2015-01-14 | 韩字光 | Plant empty capsule and manufacturing method thereof |
CN104224747A (en) * | 2014-09-09 | 2014-12-24 | 浙江万里学院 | Algae-based gastric pH response disintegrative empty capsule and preparation method thereof |
CN109497052A (en) * | 2018-12-29 | 2019-03-22 | 青岛海大生物集团有限公司 | A kind of polysaccharide is used as the preparation process of agricultural-chemical suspension auxiliary agent |
CN109497052B (en) * | 2018-12-29 | 2021-03-12 | 青岛海大生物集团有限公司 | Preparation process of polysaccharide used as pesticide suspension auxiliary |
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Application publication date: 20130515 |