CN103948561A - High-calcium plant-derived hollow capsule and preparation method and application thereof - Google Patents
High-calcium plant-derived hollow capsule and preparation method and application thereof Download PDFInfo
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- CN103948561A CN103948561A CN201410009066.7A CN201410009066A CN103948561A CN 103948561 A CN103948561 A CN 103948561A CN 201410009066 A CN201410009066 A CN 201410009066A CN 103948561 A CN103948561 A CN 103948561A
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- blastaea
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Abstract
The invention relates to a high-calcium plant-derived hollow capsule, which comprises the following components by weight: 2-5 parts of carrageenan, 1.5-5 parts of soluble starch, 1-3 parts of calcium carbonate, 0.5-2 parts of a plasticizer and 80-90 parts of water. The hollow capsule obtained by the invention not only has various functions of the existing hollow capsule, and but also uses carrageenan with biological activity, safety and no toxic or side effects, so that the hollow capsule has health care function. The raw materials and manufacturing method of the capsule are fully consistent with the medical and food requirements, so the capsule can be applied to the fields of food and medicine.
Description
Technical field
The invention belongs to medicine, food processing Material Field, relate to a kind of edible film, plant-derived Capsules of especially a kind of high calcium and its preparation method and application.
Background technology
Capsules is mainly used in splendid attire solid drugs, really for user has solved difficult entrance, mouthfeel is poor, has accomplished that good medicine is no longer bitter to the taste and has been widely used in field of medicaments and field of health care products.
The primary raw material of tradition Capsules is gelatin, have viscosity high, freeze that power is high, the easy physical characteristics such as congeal.
Carrageenan (claiming again carrageenin, antler glue) is a kind of water solublity colloid extracting in red algae, is one of the world's three large alginate jelly industrial products.Carrageenan can, as the raw material of Capsules, mainly have been applied the characteristic of its gel.The gel formation process of carrageenan is divided into 4 stages: the first stage, carrageenan is dissolved in hot water, and its molecule forms irregular curling shape; Second stage, when temperature drops to a certain degree, its molecule transforms to spiralization, forms single-screw body; Phase III, temperature declines again, and intermolecular formation double helix is space network, at this moment starts to have solidification phenomenon; Fourth stage, temperature declines again, and double helix is assembled formation gel.Carrageenan has multiple biological activity, research shows, the derivant obtaining after carrageenan and molecular modification thereof has antitumor, anticoagulation, the immunity of enhancing human body cell and humoral immunity, and antiviral, especially suppress many-sided biological activitys such as HIV (human immunodeficiency virus) (HIV), also can there is good synergism with other anti-AIDS drugs simultaneously.Therefore, the raw material with carrageenan as Capsules, not only can eliminate the negative effect bringing because of " toxic capsule " event, and can also when Capsules disintegrate, induce or produce the factor useful to human body, be to kill two birds with one stone.
The ready-to-serve calcium carbonate of food stage calcium carbonate.Adding calcium carbonate is mainly the mechanical performance that calcium carbonate can improve carrageenan gel, makes the mechanical performance of the hard capsule case that obtains reach optimum.In addition, the hydrochloric acid reaction of calcium carbonate in can stomach function regulating generates Ca
2+ion, is then absorbed by the body.
At present, carrageenan is mainly as in food additive application and milk product, or is being applied in the aspects such as edible film.Application aspect in medicinal hollow capsule rarely has research, and calcium carbonate applications is in there is no pertinent literature report as Capsules aspect.
Summary of the invention
Main purpose of the present invention is to overcome the deficiencies in the prior art part, provide a kind of and be cylindric, milky, smooth surface and high resilience, the various functions not only with existing Capsules, has expanded territory of use, has improved the value of Capsules, shortened plant-derived Capsules of high calcium of disintegration time and preparation method thereof, the plant-derived Capsules of this high calcium can be applied in medicine and field of health care food.
The technical solution adopted for the present invention to solve the technical problems is:
The plant-derived Capsules of high calcium, its constituent and parts by weight are as follows:
And plasticizer used is glycerol or Polyethylene Glycol.
The preparation method of the plant-derived Capsules of high calcium as above, step is as follows:
(1) colloidal sol: after fully being mixed, carrageenan, soluble starch, calcium carbonate, plasticizer be added to the water, heating in water bath to 70 ± 1 ℃, constant temperature is until form glue;
(2) froth breaking: the bubble in vacuum drawn glue or standing until there is no bubble in 65-75 ℃ of thermostat water bath;
(3) dip in gum forming: with being fixed on some on flat board, steel tringle is dipped in to step (2) in the glue of gained, proposes liquid level and template is dug again after the several seconds, be blown into cold wind, make glue Homogeneous Cooling, one-shot forming obtains blastaea;
(4) dry: by step (3) the blastaea of gained put into hothouse, by the dry airs of 20 ± 5 ℃, make blastaea eliminating moisture gradually;
(5) (4) step is cut after the blastaea demoulding of gained, after cutting, obtains capsule cap and capsule body, detect qualified after, obtain the plant-derived Capsules of high calcium.
And, the step of dipping in gum forming of described step in is (3): glue is placed in to constant temperature and dips in glue case, with the steel tringle being fixed on flat board, be dipped in the glue dipping in glue case, propose liquid level after dipping in glue, by tringle continuous overturning two weeks, glue is cooling forming on mould again.
The plant-derived Capsules of high calcium as above can be in the application of medicine and field of health care food.
Advantage of the present invention and good effect are:
1, the plant-derived Capsules of high calcium of the present invention is that to take carrageenan, calcium carbonate, soluble starch etc. be primary raw material, system by can fit and sealed cap and body two joints form, be cylindric, milky, smooth surface and high resilience, not only have the various functions of existing Capsules, and replaced common Capsules primary raw material gelatin used with carrageenan, avoided clashing with the faith of some minority name family, expanded the scope of territory of use.
2, the carrageenan adopting in the plant-derived Capsules of high calcium of the present invention extracts from red algae, its leaching process is simple and easy to control, can not introduce in process of production noxious substance, and FAO (Food and Agriculture Organization of the United Nation) and the (JECFA of Expert C-on Food Additive of World Health Organization (WHO), Joint FAO/WHO Expert Committee on Food Additives) calendar year 2001 has been cancelled carrageenan day permission intake (ADI, Acceptable Daily Intake) restriction, confirms that it is food additive safe, nontoxic, that have no side effect.Therefore, carrageenan completely can be for food and field of medicaments.
3, in preparation method of the present invention, add food stage calcium carbonate, not only can make resulting capsule shells more have texture, also introduced Ca simultaneously
2+ion (0.5%), has improved the value of Capsules.Food stage calcium carbonate very easily with stomach in gastric acid react, (GB requires disintegration time disintegrate completely in 30 minutes in gastric juice of conventional capsule shells to make disintegration time shortening, the capsule shells that the present invention obtains gets final product complete disintegrate for 10 minutes), also avoided the utilization of disintegrate material, made resulting capsule shells green health more simultaneously.
4, the composition of Capsules of the present invention and preparation method meet the requirement of medicine and food completely, so this Capsules can be applied food and medicine field.
The specific embodiment
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
The raw material using in the present invention, as without specific (special) requirements, is conventional commercially available prod; The method of using in the present invention, if no special instructions, is the conventional method of this area.
Embodiment 1
The plant-derived Capsules of high calcium, its constituent and weight are as follows:
The plant-derived Capsules preparation method of high calcium as above, preparation process is as follows:
1, colloidal sol: after fully being mixed, carrageenan, soluble starch, calcium carbonate and glycerol is added to the water, heating in water bath to 70 ± 1 ℃, constant temperature is until form glue;
2, froth breaking: the bubble in vacuum drawn glue or standing until there is no bubble in 65 ℃ of thermostat water baths;
3, dip in gum forming: be fixed on flat board some to steel tringle be dipped in step (2) certain depth in the glue of gained (according to the size of model difference to some extent, approximately arrive 3/4ths places of tringle), 5-10 proposes liquid level and template is dug again after second, be blown into the cold wind of 10 ℃ of left and right, make glue Homogeneous Cooling, one-shot forming obtains blastaea;
4, dry: by step (3) the blastaea of gained put into hothouse, the dry air by 23 ℃ of left and right makes blastaea get rid of gradually and accurately moisture;
5, demoulding cutting: (4) step is cut into the length of regulation after the blastaea demoulding of gained, obtain capsule cap and capsule body after cutting;
6, detect: after hollow capsule cap and capsule body are qualified after testing by GB, obtain the plant-derived Capsules of high calcium.
Embodiment 2
The plant-derived Capsules of high calcium, its constituent and weight are as follows:
The plant-derived Capsules preparation method of high calcium as above, preparation process is as follows:
1, colloidal sol: after fully being mixed, carrageenan, soluble starch, calcium carbonate and Polyethylene Glycol be added to the water, heating in water bath to 70 ± 1 ℃, constant temperature is until form glue;
2, froth breaking: the bubble in vacuum drawn glue or standing until there is no bubble in 65 ℃ of thermostat water baths;
3, dip in gum forming: glue is placed in to constant temperature and dips in glue case, with the steel tringle being fixed on flat board, be dipped in the glue dipping in glue case, propose liquid level after dipping in glue, then by tringle continuous overturning two weeks, glue is blown into the cold wind molding of 10 ℃ of left and right on mould, obtains blastaea;
4, dry: by step (3) the blastaea of gained put into hothouse, the dry air by 20 ℃ of left and right makes blastaea get rid of gradually and accurately moisture;
5, demoulding cutting: (4) step is cut into the length of regulation after the blastaea demoulding of gained, obtain capsule cap and capsule body after cutting;
6, detect: after hollow capsule cap and capsule body are qualified after testing by GB, obtain the plant-derived Capsules of high calcium.
The physical and chemical quality indexes of the plant-derived Capsules of high calcium that the present invention obtains meets the standard of the Capsules of national < < pharmacopeia > > regulation, this Capsules shell is cylindric, milky, matter is hard and flexible, there is higher safety, meet the requirement of medicine and food completely, can be used in the fields such as medicine and health food; GB requires disintegration time disintegrate completely in 30 minutes in gastric juice of conventional capsule shells, and the plant-derived Capsules of this high calcium gets final product complete disintegrate in 10 minutes, has greatly shortened disintegration time.
Claims (5)
1. the plant-derived Capsules of high calcium, is characterized in that: its constituent and parts by weight are as follows:
Carrageenan 2-5 part;
Soluble starch 1.5-5 part;
Calcium carbonate 1-3 part;
Plasticizer 0.5-2 part;
Water 80-90 part.
2. the plant-derived Capsules of high calcium according to claim 1, is characterized in that: plasticizer used is glycerol or Polyethylene Glycol.
3. a preparation method for the plant-derived Capsules of high calcium as claimed in claim 1 or 2, is characterized in that: step is as follows:
(1) colloidal sol: after fully being mixed, carrageenan, soluble starch, calcium carbonate, plasticizer be added to the water, heating in water bath to 70 ± 1 ℃, constant temperature is until form glue;
(2) froth breaking: the bubble in vacuum drawn glue or standing until there is no bubble in 65-75 ℃ of thermostat water bath;
(3) dip in gum forming: with being fixed on some on flat board, steel tringle is dipped in to step (2) in the glue of gained, proposes liquid level and template is dug again after the several seconds, be blown into cold wind, make glue Homogeneous Cooling, one-shot forming obtains blastaea;
(4) dry: by step (3) the blastaea of gained put into hothouse, by the dry airs of 20 ± 5 ℃, make blastaea eliminating moisture gradually;
(5) (4) step is cut after the blastaea demoulding of gained, after cutting, obtains capsule cap and capsule body, detect qualified after, obtain the plant-derived Capsules of high calcium.
4. the plant-derived Capsules preparation method of high calcium according to claim 3, it is characterized in that: the step of dipping in gum forming of described step in is (3): glue is placed in to constant temperature and dips in glue case, with the steel tringle being fixed on flat board, be dipped in the glue dipping in glue case, after dipping in glue, liquid level is proposed, by tringle continuous overturning two weeks, glue is cooling forming on mould again.
5. the plant-derived Capsules of high calcium as described in claim 1 to 4 any one can be in the application of medicine and field of health care food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410009066.7A CN103948561A (en) | 2014-01-08 | 2014-01-08 | High-calcium plant-derived hollow capsule and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410009066.7A CN103948561A (en) | 2014-01-08 | 2014-01-08 | High-calcium plant-derived hollow capsule and preparation method and application thereof |
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| CN103948561A true CN103948561A (en) | 2014-07-30 |
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| CN201410009066.7A Pending CN103948561A (en) | 2014-01-08 | 2014-01-08 | High-calcium plant-derived hollow capsule and preparation method and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922089A (en) * | 2015-06-12 | 2015-09-23 | 湖南尔康制药股份有限公司 | Preparation method of high-performance starch capsule |
| CN111000821A (en) * | 2019-12-30 | 2020-04-14 | 河南新孚望新材料科技有限公司 | Hydroxypropyl starch empty capsule and preparation method thereof |
| CN115322449A (en) * | 2022-09-16 | 2022-11-11 | 东莞东美食品有限公司 | Preparation process of modified starch plant capsule |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606919A (en) * | 2008-06-21 | 2009-12-23 | 方家淇 | Produce the method for medical capsule shells with carrageenan |
| CN103191433A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Safe hollow capsules using plant starch as raw material and preparation process thereof |
| CN103315975A (en) * | 2013-06-05 | 2013-09-25 | 天津科技大学 | Gelatin-CaCO3 mineral capsule shell and preparation method thereof |
-
2014
- 2014-01-08 CN CN201410009066.7A patent/CN103948561A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606919A (en) * | 2008-06-21 | 2009-12-23 | 方家淇 | Produce the method for medical capsule shells with carrageenan |
| CN103191433A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Safe hollow capsules using plant starch as raw material and preparation process thereof |
| CN103315975A (en) * | 2013-06-05 | 2013-09-25 | 天津科技大学 | Gelatin-CaCO3 mineral capsule shell and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杜伏玲等: "卡拉胶/淀粉共混膜的制备与性能研究", 《包装工程》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922089A (en) * | 2015-06-12 | 2015-09-23 | 湖南尔康制药股份有限公司 | Preparation method of high-performance starch capsule |
| CN111000821A (en) * | 2019-12-30 | 2020-04-14 | 河南新孚望新材料科技有限公司 | Hydroxypropyl starch empty capsule and preparation method thereof |
| CN115322449A (en) * | 2022-09-16 | 2022-11-11 | 东莞东美食品有限公司 | Preparation process of modified starch plant capsule |
| CN115322449B (en) * | 2022-09-16 | 2023-10-20 | 东莞东美食品有限公司 | Preparation process of modified starch plant capsule |
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Application publication date: 20140730 |
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