CN102805871B - Material of soybean polysaccharide hollow capsule and production method of capsule - Google Patents
Material of soybean polysaccharide hollow capsule and production method of capsule Download PDFInfo
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- CN102805871B CN102805871B CN201110147012.3A CN201110147012A CN102805871B CN 102805871 B CN102805871 B CN 102805871B CN 201110147012 A CN201110147012 A CN 201110147012A CN 102805871 B CN102805871 B CN 102805871B
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Abstract
The invention provides a material of a soybean polysaccharide hollow capsule, and aims to solve the problems of poor friability and poor disintegration existing in the conventional hollow capsule. According to the technical scheme of the invention, the material comprises the following components in percentage by weight: 32-42 percent of soybean polysaccharides, 45-54 percent of pulullan polysaccharides, 2-10 percent of a humectant and 4-8 percent of a gel. The soybean polysaccharide hollow capsule is prepared from the material by the following steps of: a, fully mixing all components, adding water, mixing and stirring uniformly; b, putting a mixture obtained by stirring uniformly in the step a into a water bath for dissolving, removing air bubbles, cooling in a water bath, and preserving heat for 30-40 minutes to obtain a colloid; and c, dipping glue, drying, cutting and combining to obtain the soybean polysaccharide hollow capsule. The hollow capsule prepared by taking the material as a raw material has high friability and high disintegration, and the quality of the hollow capsule is not reduced if the hollow capsule is preserved for a long time.
Description
Technical field
The present invention is specifically related to a kind of production method of material and capsule of Capsules, particularly a kind of material of soybean polysaccharide body Capsules and the production method of capsule.
Background technology
At present, Capsules comprises that the main component of hard capsule and soft capsule is gelatin, its production technology is mainly to utilize the skin from animal, the gelatin that bone extracts, and adds some plasticizers, edible pigment and opacifier and make gelatin solution, then dips in glue, solidifies, dries and form with mould.This capsule by manufacturing of gelatin affects because gelatin contains the composition that animal proteinum is subject to environmental change and in-built medicine after filling medicine, has the defect such as easily become fragile, degeneration, disintegration exceed standard.And because gelatin is to extract from the skin of some animal, the people of faith Islam, kosher cannot eat, popular due to bovine spongiform encephalopathy, foot and mouth disease, causes gelatin to occur security hidden trouble.
The patent of domestic applications plant hollow capsule is many at present, Chinese patent prospectus CN1483393 (a kind of starch Capsules wherein, it is characterized in that, described starch Capsules is by plant amylum or starch derivatives, plasticizer, the components such as water form, described plant amylum or starch derivatives, plasticizer, the percentage by weight of water is plant amylum or starch derivatives 25%-94.9%, plasticizer 0.1%-30%, water 5%-20%), CN1623529A (a kind of compositions of making Capsules, the compositions key component mass content that it is characterized in that described Capsules is as follows: a kind of compositions of making Capsules, the compositions key component mass content that it is characterized in that described Capsules is as follows: 2000 parts of pure water, 300～420 parts of potato starch, 10～20 parts of carrageenans), CN1739488A (a kind of preparation method of composite hollow konjaku capsule, it is characterized in that: Rhizoma amorphophalli glucomannan is through hydrochloric acidolysis and hydrogen peroxide oxidation modification, add vegetable protein or animal gelatin polymerization and generate composite high-molecular, through colloidal sol, insulation, dip in glue, dry and releasing process process makes composite hollow konjaku capsule, and, the raw material weight percentage ratio of preparing composite hollow konjaku capsule is: acid hydrolysis oxidative Rhizoma amorphophalli glucomannan 3.5～31.5%, vegetable protein or animal gelatin or isinglass 3.5～31.5%, glycerol 0.2～0.6%, dodecane sulfonate 0.01～0.07%, food coloring 0.01～0.03%, ethyl hydroxybenzoate 0.01～0.03%, all the other are water, and make solid content reach 20～35%), they are major ingredient with starch or modified starch etc., are equipped with various adjuvants, have solved some problem of gelatin.But their shortcoming is common, friability is not very desirable, and friability is bad, just affects probability on Capsules production and filling machine.
An other class is to take water-soluble cellulose as primary raw material, as CN1418081A, CN1329478A, CN1202102A etc., their common feature is to take water-soluble cellulose or derivatives thereof as raw material, and it is not pure natural prodcuts, these cellulosicss, but its poor mobile performance, disintegration are unstable, and cost is high, is difficult to adapt to mechanized filling medicine, and after long preservation, the phenomenon that easily occurs yellowing and a mist, not only outward appearance is not attractive in appearance, and its inherent quality declines to some extent.
The patent of simple pulullan polysaccharide empty capsule also has, patent No. CN101069677A (a kind of pullulan polysaccharide hollow hard capasule for example, it is characterized in that, comprise following component and percentage by weight: pulullan polysaccharide 58～96%, gel 0～10%, flocculation aid 0～2%, surfactant 0～5%, wetting agent 0～5%, surplus is aequum moisture; Described gel is one or more in carrageenan, agar, pectin, sodium alginate; Described flocculation aid is one or more in potassium chloride, calcium chloride, potassium phosphate, potassium citrate; Described surfactant is one or more in dodecyl sodium sulfate, Tween 80, span; Described wetting agent is one or more in glycerol, dimethicone, Oleum Ricini).Pulullan polysaccharide empty capsule in the mensuration of friability, although meet the requirement of Chinese Pharmacopoeia Capsules,, can not reach pharmaceutical factory requirement.Concerning pharmaceutical factory, breakage is all unacceptable 1%, because, medicine or the health product of wanting recipient plant Capsules to fill, price general charged is all more expensive, in the time of upper machine, all needs probability 100%, reduce the loss of powder filler, breakage will produce huge economic loss in 1% accumulation.
Therefore, need a kind of plant hollow capsule, can separate the shortcoming of cassia gum Capsules, also should have good friability index, disintegration index, and low price, be convenient to long preservation.
Summary of the invention
An object of the present invention is to provide a kind of material of soybean polysaccharide body Capsules, the Capsules that uses this kind of material to prepare as raw material has solved the problem that prior art occurs, its capsule friability, disintegration are good, the phenomenon that there will not be yellowing and a mist after long preservation, appearance looks elegant, its inherent quality can not decline.
Another object of the present invention is the production method that the material of the above-mentioned soybean polysaccharide body Capsules of employing is prepared Capsules.
The present invention's technical scheme adopting of dealing with problems is:
The material that the invention provides a kind of soybean polysaccharide body Capsules, includes solid material and fluent material; In the situation that the described solid material weight of take is 100%: include soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% according to this solid material of percentage by weight; Described fluent material is water.
The soybean polysaccharide body that wherein preferred viscosities is 10----100cps.
Wherein preferred molecular weight is 50,000---800,000 pulullan polysaccharide.
Wherein wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
In a specific embodiment of the present invention, described gel is selected from gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination.More preferably κ type carrageenan.
In another specific embodiment of the present invention, in fluent material, add in addition flocculation aid, flocculation aid in fluent material content be 0---0.05% (w/v).
Preferably, described flocculation aid is selected from following flocculation aid: potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination.
More preferably, flocculation aid is potassium chloride.
The present invention also provides a kind of production method of soybean polysaccharide body Capsules, comprises the following steps:
A, get soybean polysaccharide body 32----42% by weight percentage, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8%, after all the components is fully mixed, adds water mixing and stirring;
B, the mixture stirring is placed in to 80 ℃ of-90 ℃ of water-baths dissolves and eliminate bubble in step 1, water-bath cools to 50 ℃-52 ℃, 50 ℃-52 ℃ insulations, within 30-40 minute, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
The present invention also provides a kind of production method of soybean polysaccharide body Capsules in addition, comprises the following steps:
A, get soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10% by weight percentage, gel 4---8%, adds water mixing and stirring, then adds flocculation aid, the content of flocculation aid in water is 0---0.05%, by the abundant mixing and stirring of all the components;
B, the mixture stirring is placed in to 80 ℃ of-90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃-52 ℃, 50 ℃-52 ℃ insulations, within 30-40 minute, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
Beneficial effect of the present invention:
Soybean polysaccharide body be from Semen sojae atricolor, refine make by the molecular Powdered polysaccharose substance of galactose, arabinose, galactobionic acid Galactonic acid, rhamnose, trehalose, xylose and glucose decile.In the present invention, adopt soybean polysaccharide body to replace gelatin, various crowds can be eaten, the edible hidden danger of simultaneously having avoided some Animal diseases to bring.
2. through evidence, the Capsules that adopts standby its friability of Capsules of soybean polysaccharide system to be better than to take other plant class to prepare as raw material as plant amylum or starch derivatives, water-soluble cellulose or derivatives thereof, can not affect medicine and fill.Simultaneously due to the chemical property of water-soluble cellulose itself, the long time stored rear phenomenon that easily occurs yellowing and a mist of Capsules that the water-soluble cellulose of take is prepared as raw material, not only outward appearance is not attractive in appearance, and the inherent quality of capsule can not decline to some extent.In the present invention, adopting soybean polysaccharide body is that raw material is prepared Capsules, can avoid producing the problems referred to above.
3. soybean polysaccharide body is to refine and make from Semen sojae atricolor, is pure natural plant raw material, harmless.And plant amylum or starch derivatives, water-soluble cellulose or derivatives thereof etc. are not pure natural plant raw material.
The specific embodiment
The invention provides a kind of material of soybean polysaccharide body Capsules, according to this material of percentage by weight, include soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8%.
The soybean polysaccharide body that wherein preferred viscosities is 10----100cps.
Wherein preferred molecular weight is 50,000---800,000 pulullan polysaccharide.
Wherein wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
Described gel selects gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination, more preferably κ type carrageenan.
In the present invention, in fluent material, add in addition flocculation aid, flocculation aid in fluent material content be 0---0.05% (w/v).
Preferably, described flocculation aid is selected from following flocculation aid: potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination.
More preferably, flocculation aid is potassium chloride.
Below the various compositions of soybean polysaccharide body Capsules material of the present invention are described respectively.
Soybean polysaccharide body
Soybean polysaccharide body is to take Semen sojae atricolor as raw material, through defat, extraction, separation, purification, sterilizing, the technique such as dry, make by the molecular Powdered polysaccharose substance of galactose, arabinose, galactobionic acid Galactonic acid, rhamnose, trehalose, xylose and glucose decile.Soybean polysaccharide body contains the dietary fiber that is greater than 65%, has the intestinal physiology function that general water soluble dietary fiber is the same.Soybean polysaccharide body is soluble in hot water or cold water, can prepare the aqueous solution that surpasses 10%, and there will not be gelatin phenomenon.The solution viscosity of soybean polysaccharide body is low, heat-resisting, acidproof, and inorganic salt does not have impact substantially on it, has higher stability.The soybean polysaccharide body that in the present invention, preferred viscosities is 10----100cps.
Pulullan polysaccharide
Pulullan polysaccharide is the outer water solublity cement polysaccharide of born of the same parents of a kind of similar glucosan being produced by Aureobasidium pullulans fermentation, xanthan gum, and it is a kind of special microbial polysaccharide of being found by R.Bauer for 1938.This polysaccharide is by α-1, the maltotriose recurring unit that 4 glycosidic bonds connect is through α-1, the straight chain shape polysaccharide that 6 glycosidic bonds are polymerized, molecular weight is between 4.8x10～2.2x10 (commodity pulullan polysaccharide mean molecule quantity 2x105. is approximately comprised of 480 maltotrioses) generally.This polysaccharide has two important characteristics: high resilience in structure, dissolubility is larger.The film property of pulullan polysaccharide, gas barrier property, plasticity, viscosity are all stronger, and have the good characteristics such as soluble in water, nontoxic, colorless and odorless, have been widely used in the fields such as medicine, food, light industry, chemical industry and oil.In the present invention, preferred molecular weight is 50,000---800,000 pulullan polysaccharide.
Wetting agent
Because < < Pharmacopoeia of People's Republic of China > > has requirement to the friability of Capsules, and in Capsules, must keep moisture just can make its friability reach requirement, therefore add in the present invention wetting agent.Described wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
Gel
Gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination.Preferred κ type carrageenan.
Flocculation aid
Sometimes glue gel time extends, and can make Capsules thickness not reach evenly, therefore can suitably increase flocculation aid, and in the present invention, flocculation aid is selected from potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination, preferably potassium chloride.
Except said components, soybean polysaccharide body Capsules of the present invention can also add other additives as required, adjuvants such as pigment, flavoring agent, surfactant (dodecyl sodium sulfate), and these adjuvants are all adjuvants conventional in prior art.The component of described other additive is not particularly limited, only otherwise the object of the invention is produced to restriction.
The present invention also provides a kind of production method of soybean polysaccharide body Capsules, comprises the following steps:
A, get soybean polysaccharide body 32----42% by weight percentage, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8%, after all the components is fully mixed, adds water mixing and stirring;
B, the mixture stirring is placed in to 80 ℃ of-90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃-52 ℃, 50 ℃-52 ℃ insulations, within 30-40 minute, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
In a specific embodiment of the production method of soybean polysaccharide body Capsules of the present invention, comprise the following steps:
A, get soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10% by weight percentage, gel 4---8%, adds water mixing and stirring, then adds flocculation aid, the content of flocculation aid in water is 0---0.05%, by the abundant mixing and stirring of all the components;
B, the mixture stirring is placed in to 80 ℃ of-90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃-52 ℃, 50 ℃-52 ℃ insulations, within 30-40 minute, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 2022 ℃.
Embodiment 1
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃, 50 ℃ of insulations, within 30 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20 ℃-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses are without breakage.Be 15 minutes disintegration.
Embodiment 2
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 85 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 52 ℃, 52 ℃ of insulations, within 35 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20 ℃-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses are without breakage.Be 13 minutes disintegration.
Embodiment 3
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃, 50 ℃ of insulations, within 40 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses are without breakage.Be 15 minutes disintegration.
Embodiment 4
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 89 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃, 50 ℃ of insulations, within 32 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses are without breakage.Be 13 minutes disintegration.
Embodiment 5
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 88 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 51 ℃, 51 ℃ of insulations, within 34 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses have 5 breakages.Be 14 minutes disintegration.
Embodiment 6
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 87 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 51 ℃, 51 ℃ of insulations, within 38 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses are without breakage.Be 15 minutes disintegration.
Embodiment 7
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 86 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 51 ℃, 51 ℃ of insulations, within 30 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses are without breakage.Be 13 minutes disintegration.
Embodiment 8
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 87 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 552 ℃, 52 ℃ of insulations, within 32 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses have 3 breakages.Be 15 minutes disintegration.
Embodiment 9
Specific operation process is as follows:
A, above-mentioned each solid constituent is fully mixed after, add water mixing and stirring;
B, the mixture stirring is placed in to 90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃, 50 ℃ of insulations, within 30 minutes, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
By the above-mentioned soybean polysaccharide body Capsules making according in < < Pharmacopoeia of People's Republic of China > >, the regulation of gelatin Capsules friability and disintegration being tested.
Result: friability; 50 soybean polysaccharide body Capsuleses are without breakage.Be 14 minutes disintegration.
Claims (11)
1. the material of soybean polysaccharide body Capsules, is characterized in that: include solid material and fluent material; In the situation that the described solid material weight of take is 100%: include soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% according to this solid material of percentage by weight; Described fluent material is water.
2. the material of soybean polysaccharide body Capsules as described in claim 1, is characterized in that: the soybean polysaccharide body that preferred viscosities is 10----100cps.
3. the material of soybean polysaccharide body Capsules as described in claim 1, is characterized in that: preferred molecular weight is 50,000---800,000 pulullan polysaccharide.
4. the material of soybean polysaccharide body Capsules as described in claim 1, is characterized in that: described wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
5. the material of soybean polysaccharide body Capsules as described in claim 1, is characterized in that: described gel is selected from gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination.
6. the material of soybean polysaccharide body Capsules as described in claim 5, is characterized in that: the preferred κ type of described gel carrageenan.
7. the material of soybean polysaccharide body Capsules as described in claim 1, is characterized in that: in fluent material, add in addition flocculation aid, flocculation aid in fluent material content be 0---0.05%(w/v).
8. the material of soybean polysaccharide body Capsules as described in claim 7, is characterized in that: described flocculation aid is selected from potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination.
9. the material of soybean polysaccharide body Capsules as described in claim 8, is characterized in that: the preferred potassium chloride of described flocculation aid.
10. the production method of soybean polysaccharide body Capsules, is characterized in that: comprise the following steps
A, get soybean polysaccharide body 32----42% by weight percentage, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8%, after all the components is fully mixed, adds water mixing and stirring;
B, the mixture stirring is placed in to 85 ℃ of-90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃-52 ℃, 50 ℃-52 ℃ insulations, within 30-40 minute, becomes colloid;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
The production method of 11. soybean polysaccharide body Capsuleses, is characterized in that: comprise the following steps
A, get soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10% by weight percentage, gel 4---8%, adds water mixing and stirring, then adds flocculation aid, the content of flocculation aid in water is 0---0.05%, by the abundant mixing and stirring of all the components;
B, the mixture stirring is placed in to 85 ℃ of-90 ℃ of water-baths dissolves and eliminate bubble in step a, water-bath cools to 50 ℃-52 ℃, 50 ℃-52 ℃ insulations, within 30-40 minute, becomes colloid; ;
C, then dip in glue, oven dry, cutting, fit, obtain soybean polysaccharide body Capsules;
Its whole production process keeps room temperature at 20-22 ℃.
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| CN106038304A (en) * | 2016-05-20 | 2016-10-26 | 夏放军 | Empty capsule |
| CN111885922A (en) * | 2018-03-16 | 2020-11-03 | 味之素株式会社 | Additive for feed and feed |
| CN108721632B (en) * | 2018-06-27 | 2021-10-22 | 中国海洋大学 | High molecular weight pullulan additive and application thereof in capsule preparation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003125714A (en) * | 2001-10-29 | 2003-05-07 | Ina Food Ind Co Ltd | Capsule base material and capsule made from the base material, and method for producing the capsule base material |
| CN101069677A (en) * | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | Pullulan polysaccharide hollow hard capasule and its preparing method |
| CN101693020A (en) * | 2009-10-22 | 2010-04-14 | 华慧颖 | Enteric soluble medicine empty capsule prepared by replacing part of gelatin with defatted soybean meal extractive and preparation process |
-
2011
- 2011-06-02 CN CN201110147012.3A patent/CN102805871B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003125714A (en) * | 2001-10-29 | 2003-05-07 | Ina Food Ind Co Ltd | Capsule base material and capsule made from the base material, and method for producing the capsule base material |
| CN101069677A (en) * | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | Pullulan polysaccharide hollow hard capasule and its preparing method |
| CN101693020A (en) * | 2009-10-22 | 2010-04-14 | 华慧颖 | Enteric soluble medicine empty capsule prepared by replacing part of gelatin with defatted soybean meal extractive and preparation process |
Non-Patent Citations (4)
| Title |
|---|
| APINAN SOOTTITANTAWAT et. al.."Effect of Water Activity on the Release Characteristics and Oxidative Stability of D-Limonene Encapsulated by Spray Drying".《J. Agric. Food Chem.》.2004,第52卷(第5期), |
| Yasumasa MINEMOTO et. al.."Oxidation of linoleic acid encapsulated with souble soybean polysaccharide by spray-drying".《Biosci. Biotechnol. Biochem.》.2002,第66卷(第9期), |
| 华慧颖等."豆粕提取物用于药用空心胶囊制作的研究".《广西轻工业》.2011,第2011年卷(第4期), |
| 王兴敏等."以水溶性大豆多糖为壁材制备植酸酶微胶囊的研究".《食品科技》.2008,第33卷(第12期), |
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| CN102805871A (en) | 2012-12-05 |
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