CN101485643B - Plant hollow capsule - Google Patents
Plant hollow capsule Download PDFInfo
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- CN101485643B CN101485643B CN2009101162426A CN200910116242A CN101485643B CN 101485643 B CN101485643 B CN 101485643B CN 2009101162426 A CN2009101162426 A CN 2009101162426A CN 200910116242 A CN200910116242 A CN 200910116242A CN 101485643 B CN101485643 B CN 101485643B
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- capsule
- hollow capsule
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- gelatin
- capsules
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- 239000002775 capsule Substances 0.000 title claims abstract description 52
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 17
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 16
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 16
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 16
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 229920003086 cellulose ether Polymers 0.000 claims abstract description 7
- 239000001508 potassium citrate Substances 0.000 claims abstract description 7
- 229960002635 potassium citrate Drugs 0.000 claims abstract description 7
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims abstract description 7
- 235000011082 potassium citrates Nutrition 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 235000010418 carrageenan Nutrition 0.000 claims description 7
- 239000000679 carrageenan Substances 0.000 claims description 7
- 229920001525 carrageenan Polymers 0.000 claims description 7
- 229940113118 carrageenan Drugs 0.000 claims description 7
- 238000005189 flocculation Methods 0.000 claims description 7
- 230000016615 flocculation Effects 0.000 claims description 7
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 7
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 abstract description 11
- 235000019322 gelatine Nutrition 0.000 abstract description 11
- 108010010803 Gelatin Proteins 0.000 abstract description 10
- 239000008273 gelatin Substances 0.000 abstract description 10
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 10
- 239000003292 glue Substances 0.000 abstract description 10
- 238000012545 processing Methods 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 6
- 235000013311 vegetables Nutrition 0.000 abstract description 5
- 238000011049 filling Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000001509 sodium citrate Substances 0.000 abstract description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract description 2
- 239000000701 coagulant Substances 0.000 abstract 2
- 241001474374 Blennius Species 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 14
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000000576 food coloring agent Substances 0.000 description 5
- 150000004676 glycans Chemical class 0.000 description 5
- 239000003605 opacifier Substances 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 5
- 239000005017 polysaccharide Substances 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 244000275012 Sesbania cannabina Species 0.000 description 1
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229920006321 anionic cellulose Polymers 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229920006335 epoxy glue Polymers 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- -1 hydroxypropyl Chemical group 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a vegetable hollow capsule, which is prepared by taking cellulose ether as a raw material. The hollow capsule is characterized by comprising the following components in percentage by weight: 80 to 90 percent of carboxymethyl cellulose, 1.5 to 10 percent of curing agent and 1.5 to 10 percent of coagulant aid, wherein the curing agent is selected from one or mixed glue of more than two of vegetable glue, or microbial glue or seaweed glue; and the coagulant aid is selected from potassium citrate or sodium citrate and the like. Just like the gelatin hollow capsule, the preparation of the vegetable hollow capsule also comprises the preparation of glue materials and the processing of capsule shell, and the processing equipment of the gelatin hollow capsule is also used. The capsule has the advantages of bright surface gloss, good fluency, and high rate of capsule filling; moreover, the indexes such as disintegration time limit, friability at different temperatures and the like, meet national standards of the gelatin hollow capsule.
Description
One, technical field
The present invention relates to the adjuvant that a kind of pharmaceutical preparation is used, specifically a kind of plant hollow capsule with carboxymethyl cellulose processing.
Two, background technology
Capsules is the main adjuvant of processing medicament capsule preparation.The Capsules that uses is at present processed by gelatin mostly.Glue after gelatin elder generation water logging bubble, the swelling, after send the capsule manufacture line to obtain Capsules (softgel shell) through dipping in operations such as gum forming, dry solidification, cooling, cutting.Described glue is exactly the gelatin after the swelling to be dropped into to heat up in the mixing kettle with water, surfactant etc. stir, and after filtering, remove bubble, transferring proportion, obtains sizing material.
The water soluble protein that gelatin is obtained through hydrolysis by the collagen protein in the connective tissues such as the skin of animal, bone, tendon, ligament.Protein is subject to the influence of acid, alkali, and medicated powder acidity or alkalescence that Ruo Qinei fills are stronger, and practice shows; In storage process, although also in the shelf-life, the quality of capsule also seriously descends; Such as sclerosis, embrittlement, easy disintegrating not, serious only remaining a pile powder.In addition, because of the religions belief reason, take like taboos such as Islam, kosher; Epidemic situations such as " bovine spongiform encephalopathy " that occurs in recent years, " foot and mouth disease " again serious impact gelatine capsule agent market.Other feedstock production capsules that exploitation substitutes gelatin have realistic meaning.So have human hydroxypropyl emthylcellulose (HPMC) and polysaccharide to prepare Capsules.But more capsular physicochemical properties of this type such as low temperature friability, not anti-temperature storage etc. still can not be satisfactory more than 30 ℃.
Gelatin is taken from animal, and cellulose ether and polysaccharide for being different from the gelatin Capsules, claim to use the Capsules of cellulose ether and polysaccharide processing to be plant hollow capsule from plant.
Three, summary of the invention
The present invention aims to provide the new plant hollow capsule that a kind of each item physicochemical property all meets the pharmacopeia regulation, and technical problem to be solved is to select suitable cellulose ether composition.
Cellulose ether is be raw material with the native cellulose through chemistry change a social system one type of molding high molecular weight water soluble polymer that narrows, principal item has ion-type such as carboxymethyl cellulose, sulfonic acid ethyl cellulose and nonionic such as methylcellulose (CM), hydroxyethyl-cellulose (HEC) etc.The applicant is through the condition test of system, and in the cellulose ether series of products, choosing carboxymethyl cellulose (CMC) is raw material, and is aided with firming agent and flocculation aid processing plant hollow capsule, and each component has following percentage by weight:
CMC:80～96%, firming agent: 1.5～10%, flocculation aid: 1.5～10%.
Described firming agent is selected from plant gum, like arabic gum or sesbania gum or carrageenan or pectin, and perhaps microbiological gum, like gellan gum or xanthan gum, perhaps one or more epoxy glues in alginate jelly or the agar etc.Preferred carrageenan is or/and arabic gum or/and xanthan gum etc.
Described flocculation aid is selected from potassium citrate or sodium citrate or potassium chloride or calcium chloride.Optimization citric acid acid potassium.
CMC is commonly used to be the anionic cellulose ether for sodium salt, is generated by alkali fiber (native cellulose and finite concentration NaOH solution effects generate) and the reaction of etherifying agent sodium chloroacetate.In the preparation process, can obtain the CMC of different molecular weight, the molecular weight difference only influences the viscosity of CMC solution, and experiment shows that the CMC of different molecular weight all can be used to prepare Capsules.
CMC, firming agent and flocculation aid are the key components of this plant hollow capsule, and be the same with processing gelatin Capsules in addition, also can add food coloring according to actual needs or/and opacifier titanium dioxide etc.
The preparation of this Capsules also comprises the preparation of sizing material and the processing of softgel shell.CMC and water dropped into heated and stirred dissolving back adds firming agent and flocculation aid in the mixing kettle, the after-filtration that stirs, remove bubble, transfer proportion (being CMC concentration), send capsule manufacture line processing softgel shell then.
This Capsules appearance surfaces is glossy, and fluency is good, and probability is high on the capsule shells filling medicated powder, and the user uses percent defective low.And HPMC plant hollow capsule and polysaccharide vegetable Capsules appearance surfaces are lackluster, and fluency is poor, and probability is low on the capsule shells filling medicated powder, and percent defective is high, and particularly HPMC plant hollow capsule surface is poorer.
" 2 000 editions regulation Capsuleses of Chinese pharmacopoeia disintegration time is 10 minutes, and this capsule only needs 6 minutes, and other two plant capsules generally all need 10-15 minute.
Insulation is 4 hours under the different temperatures.Observe the viscosity degradation percentage rate, the comparative test result sees table 1.
Table 1:
| 45℃ | 50℃-60℃ | 70℃-80℃ | |
| The CMC plant hollow capsule | 0 | 0 | 1％ |
| Capsules | Expand and do not dissolve | 2％ | 5％ |
| The HPMC plant hollow capsule | 0 | 8％ | 100％ |
| The polysaccharide vegetable Capsules | 0 | 10％ | 25％ |
The leftover bits and pieces or the waste product that produce in this explanation CMC production process; Quality does not descend; Can reclaim use repeatedly again, product cost is just low, and other three kinds recovery service property (quality)s are poor; The leftover bits and pieces or the waste product that resemble the HPMC plant hollow capsule just can not reclaim, and this has just improved the cost of product undoubtedly.
Under the different temperatures, preserved three months, the comparative test result sees table 2.
Table 2:
Friability is by " 2 00 editions two Capsules standard operations of Chinese pharmacopoeia; 50 capsules detect with 20 gram counterweights; Crisp broken capsule does not allow to exceed 15; From these four kinds of capsules of result 15--25 ℃ can both be qualified, but CMC plant hollow capsule advantage is more obvious under low temperature and hot conditions.And Capsules is in that " Chinese pharmacopoeia 2 000 editions is clear and definite regulation just, must store (below 20 ℃) in the cool, and the capsule of these other two kinds of explanation requires relatively harshness on temperature.
Four, the specific embodiment
Below the present invention is described in further detail, and provide the specific embodiment.
Embodiment 1, get low viscosity CMC30kg, carrageenan 3kg, potassium citrate 3kg, water 64kg.
Production equipment is identical with former useful manufacturing of gelatin Capsules.Pour CMC and water into reaction pot heated and stirred, dissolving, add firming agent and flocculation aid again, 60 ℃-90 ℃ of the recirculated water water temperatures of reaction pot; Stirred 2-4 hour, fully glue is filtered with 200 purpose filter bags in the dissolving back, and glue is stored in the heat-preserving container; See proportion, regulate gelatin concentration, according to user's demand versicolor food coloring that difference adds; With add a certain amount of opacifier titanium dioxide etc.; Leave standstill insulation and remove bubble again, put into again on the capsule manufacture line, need lettering lettering etc. behind fit through dipping in glue, oven dry, cooling, the demoulding, cutting, fit, check, packing.
Embodiment 2, get medium viscosity (FM
6) CMC25kg, arabic gum 1.5kg, carrageenan 1kg, potassium citrate 2.5kg, water 70kg.Also can be according to user's demand difference with adding versicolor food coloring and a certain amount of opacifier titanium dioxide etc.Its production method is with embodiment 1.
Embodiment 3, get high viscosity (FH
6) CMC20kg, xanthan gum 1.5kg, carrageenan 0.5kg, potassium citrate 2kg, water 76kg.Also can be according to user's demand difference adds versicolor food coloring and a certain amount of opacifier titanium dioxide etc.Its production method is with embodiment 1.
Embodiment 4, get extra-high-speed viscosity CMC15kg, carrageenan 1.5kg, potassium citrate 1.5kg, water 82kg also can add versicolor food coloring and a certain amount of opacifier titanium dioxide etc. according to user's demand difference.Its production method is with embodiment 1.
Claims (1)
1. plant hollow capsule; Be to be the Capsules of feedstock production by cellulose ether; It is characterized in that: each component has following percentage by weight: carboxymethyl cellulose 80～90%; Firming agent 1.5～10%, flocculation aid potassium citrate 1.5～10%, described firming agent be selected from carrageenan or/and arabic gum or/and xanthan gum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101162426A CN101485643B (en) | 2009-02-25 | 2009-02-25 | Plant hollow capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101162426A CN101485643B (en) | 2009-02-25 | 2009-02-25 | Plant hollow capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101485643A CN101485643A (en) | 2009-07-22 |
| CN101485643B true CN101485643B (en) | 2012-01-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101162426A Active CN101485643B (en) | 2009-02-25 | 2009-02-25 | Plant hollow capsule |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861114B (en) * | 2014-03-13 | 2016-08-24 | 中国科学院化学研究所 | Functional plants matrix Capsules |
| CN104000798B (en) * | 2014-06-11 | 2016-02-03 | 青岛双鲸药业有限公司 | A kind of autonomic soft capsules |
| CN106377516A (en) * | 2016-08-30 | 2017-02-08 | 浙江宏辉胶丸有限公司 | Tea plant hollow hard capsule and preparation method and application thereof |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
| CN109288809B (en) * | 2018-11-04 | 2021-06-01 | 李国桐 | Composite raw material for preparing medicinal plant capsule |
| CN109528689B (en) * | 2018-12-24 | 2021-09-21 | 江苏辰星药业股份有限公司 | Enteric slow-release plant capsule and preparation method thereof |
| CN109528676A (en) * | 2018-12-24 | 2019-03-29 | 江苏辰星药业股份有限公司 | A kind of seaweed polysaccharide plant soft capsule and preparation method thereof |
| CN113018275B (en) * | 2021-03-11 | 2023-02-14 | 安徽黄山胶囊股份有限公司 | Povidone empty capsule and production process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167705A (en) * | 2007-11-13 | 2008-04-30 | 石海峰 | Composition for preparing plant hollow hard capsules and preparation method of capsules |
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- 2009-02-25 CN CN2009101162426A patent/CN101485643B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167705A (en) * | 2007-11-13 | 2008-04-30 | 石海峰 | Composition for preparing plant hollow hard capsules and preparation method of capsules |
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Owner name: ANHUI HUANGSHAN CAPSULE CO., LTD. Free format text: FORMER OWNER: LIU SONGLIN Effective date: 20121217 |
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Free format text: CORRECT: ADDRESS; FROM: 242600 XUANCHENG, ANHUI PROVINCE TO: 242605 XUANCHENG, ANHUI PROVINCE |
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Effective date of registration: 20121217 Address after: 242605 Anhui, Xuancheng County, Jingde Province, Hong Chuan Patentee after: Anhui Huangshan Capsule Co.,Ltd. Address before: 242600 Anhui County of Jingde province Jingyang town Liang Jia No. 5 Patentee before: Liu Songlin |