CN103861114B - Functional plants matrix Capsules - Google Patents
Functional plants matrix Capsules Download PDFInfo
- Publication number
- CN103861114B CN103861114B CN201410093021.2A CN201410093021A CN103861114B CN 103861114 B CN103861114 B CN 103861114B CN 201410093021 A CN201410093021 A CN 201410093021A CN 103861114 B CN103861114 B CN 103861114B
- Authority
- CN
- China
- Prior art keywords
- functional
- capsules
- gelling agent
- matrix
- functional plants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to be widely used in the capsule of medicine, health products and food service industry, particularly to functional plants matrix Capsules.Described functional plants matrix Capsules be by based on matrix cellulose and flocculation aid and as the Blackfungus polyhexose of functional gelling agent and the mixture of flaxseed gum, the raw material for preparing Capsules obtained after mixing, then uses routine to prepare the technique of Capsules and is prepared and obtains.The functional plants matrix Capsules of the present invention is noteworthy characterized by the functional gelling agent selecting to have the Blackfungus polyhexose of Biofunctional effect and the mixture of flaxseed gum as Capsules, the functional plants matrix Capsules that this functional gelling agent and cellulose family bio-matrix and flocculation aid prepare has possessed the notable functional characteristic not available for existing gelatin hollow capsule, and this functional plants matrix Capsules can be widely applied to medicine, health products and food service industry.
Description
Technical field
The present invention relates to be widely used in the capsule of medicine, health products and food service industry, particularly to functional
Plant substrates Capsules.
Background technology
The gelatin utilizing the collagen in the skin of animal, bone tissue to obtain after hydrolysis is prepared medicinal hollow
Capsule, has had long history, owing to the drug ingedient of Capsules parcel can avoid medicine itself
Sensory stimulation to human body, and reach medicine slow release effect in vivo, for a long time with gelatin
Capsules for raw material is widely used at medicine, field of food.As medicine and health products
Main encapsulating material, its defect is also recognized by everybody.If the protein of self is easily by acid, alkali shadow
Ring, limit the use of some drugs.Gelatin molecule is contained within more active group, it is easy to contact
Medicine react, thus change the character of medicine.Have again environment is dried, moist and temperature
The sensitivity of change, have impact on quality and the use of capsule.
In view of the deficiency that gelatine capsule is above-mentioned, the capsule based on plant causes researcher and the producer
Interest.The a large amount of patent reports progress of this kind of work, as CN101485643A, CN1778304A,
CN1606978A etc., wherein Pfizer Inc.'s HPMC (HPMC) with plant as raw material
Non-gelatin capsules Vcaps for matrix has successfully pushed market to, and receives the accreditation of consumers in general.
But also it is reported that, the disintegration time limited of this kind of capsule is longer, and low temperature crisp essence degree, more than 30 DEG C
The physicochemical properties such as the storage of temperature are still unsatisfactory.
Summary of the invention
It is an object of the invention in the common system preparing Capsules using cellulose as host material
In Bei, there is the mixture of functional edible Blackfungus polyhexose and flaxseed gum as functional glue
Solidifying agent, thus a kind of functional plants matrix Capsules is provided.
The present invention is to have the mixture of functional edible Blackfungus polyhexose and flaxseed gum as function
Property gelling agent, instead of the natural plant gum of carragheen or other kind commonly used, Blackfungus polyhexose is many
One in many edible fungi polysaccharides, in the world, edible fungi polysaccharide is referred to as " biological respinse modifier ",
Antibacterium, antiviral and anti-coagulation effect can be had as immunopotentiator and immunoactivator, and can
Improve hypoxia-bearing capability and the utilization rate of oxygen of animal, there is reduction blood viscosity, strengthen myocardial contraction
Power, improve heart rate, hypoglycemic, calm, ease pain, relieving asthma, cough-relieving and effect of reducing phlegm.Edible mushroom is many
Above-mentioned effect of sugar, such as the gelling agent as medicament capsule or health-caring capsule, can play multiple disease
Auxiliary therapeutic action, the effect of health products is had especially and promotes that the rehabilitation of sufferer adjusts energetically and make
With, can be described as functional capsule product of new generation.
The functional plants matrix Capsules of the present invention be by based on the cellulose of matrix and flocculation aid
Prepare with the mixture of functional gelling agent.
Described functional gelling agent is the Blackfungus polyhexose in functional edible mushroom polysaccharide and flaxseed gum
Mixture.
The content of the described described cellulose in functional plants matrix Capsules is 80～95wt%,
The content of described flocculation aid is 0.01～0.5wt%, and the content of described functional gelling agent is
4.5～19.99wt%.
The described Blackfungus polyhexose in functional gelling agent with the weight percentage ratio of flaxseed gum is
1:10～10:1.
Based on described, the cellulose of matrix is selected from hydroxypropyl cellulose, hydroxyethyl cellulose, carboxylic first
One in base cellulose and HPMC.
Described flocculation aid one in potassium chloride, sodium chloride, potassium citrate and sodium citrate.
The preparation method of the functional plants matrix Capsules of the present invention is: the fibre of matrix based on by
Dimension element mixes with flocculation aid and functional gelling agent, obtains the raw material for preparing Capsules, then adopts
The technique preparing Capsules by routine is prepared Capsules, can prepare functional plants base
Matter Capsules.
The content of the described described cellulose in functional plants matrix Capsules is 80～95wt%,
The content of described flocculation aid is 0.01～0.5wt%, and the content of described functional gelling agent is
4.5～19.99wt%.
The described Blackfungus polyhexose in functional gelling agent with the weight percentage ratio of flaxseed gum is
1:10～10:1.
The functional plants matrix Capsules of the present invention is noteworthy characterized by selection and has Biofunctional work
The mixture of Blackfungus polyhexose and flaxseed gum as the functional gelling agent of Capsules, this function
The functional plants matrix Capsules that property gelling agent prepares with cellulose family bio-matrix and flocculation aid
Having possessed the notable functional characteristic not available for existing gelatin hollow capsule, this functional plants matrix is hollow
Capsule can be widely applied to medicine, health products and food service industry.
Detailed description of the invention
Embodiment 1
By potassium citrate and the gelling agent (gelling agent of 19.99g of the hydroxypropyl cellulose of 80g and 0.01g
The weight percentage of middle flaxseed gum and Blackfungus polyhexose ratio is for 1:10) mixing, obtain for preparing sky
The raw material of heart-soothing capsule, then uses tradition to dip in adhesive process and is prepared Capsules, prepare functional
Plant substrates Capsules.Prepared functional plants matrix Capsules reference Chinese Pharmacopoeia 2010
The method of version two regulation carries out friability and slaking test, uses polytetrafluoroethylene (PTFE) counterweight detection friability,
50 samples, without broken, its friability can reach pharmacopoeial requirements；Use huge sky to send out ZB-lE intelligence to collapse
Xie Yi carries out disintegration experiment, and test sample all can be disintegrated in 10 minutes, and its disintegration time limited reaches medicine
Allusion quotation requirement.
Embodiment 2
By sodium citrate and gelling agent (the gelling agent Central Asia of 9.9g of the hydroxyethyl cellulose of 90g and 0.1g
The weight percentage of fiber crops seed glue and Blackfungus polyhexose ratio is for 3:7) mixing, obtain for preparing Capsules
Raw material, then use tradition to dip in adhesive process and be prepared Capsules, prepare functional plants base
Matter Capsules.Prepared functional plants matrix Capsules is with reference to Chinese Pharmacopoeia version in 2010 two
The method of regulation carries out friability and slaking test, uses polytetrafluoroethylene (PTFE) counterweight detection friability, 50
Sample, without broken, its friability can reach pharmacopoeial requirements；Use huge sky to send out ZB lE Intelligent disintegration tester to enter
Row disintegration experiment, test sample all can be disintegrated in 10 minutes, and its disintegration time limited reaches pharmacopoeial requirements.
Embodiment 3
By potassium chloride and gelling agent (the gelling agent Central Asia of 14.5g of the hydroxymethyl cellulose of 85g and 0.5g
The weight percentage of fiber crops seed glue and Blackfungus polyhexose ratio is for 5:5) mixing, obtain for preparing Capsules
Raw material, then use tradition to dip in adhesive process and be prepared Capsules, prepare functional plants base
Matter Capsules.Prepared functional plants matrix Capsules is with reference to Chinese Pharmacopoeia version in 2010 two
The method of regulation carries out friability and slaking test, uses polytetrafluoroethylene (PTFE) counterweight detection friability, 50
Sample, without broken, its friability can reach pharmacopoeial requirements；Huge sky is used to send out ZB-lE Intelligent disintegration tester
Carrying out disintegration experiment, test sample all can be disintegrated in 10 minutes, reaches pharmacopeia its disintegration time limited and wants
Ask.
Embodiment 4
By potassium citrate and the gelling agent (gelling agent of 11.8g of the HPMC of 88g and 0.2g
The weight percentage of middle flaxseed gum and Blackfungus polyhexose ratio is for 8:2) mixing, obtain for preparing hollow
The raw material of capsule, then uses tradition to dip in adhesive process and is prepared Capsules, prepare functional planting
Thing matrix Capsules.Prepared functional plants matrix Capsules is with reference to Chinese Pharmacopoeia version in 2010
The method of two regulations carries out friability and slaking test, uses polytetrafluoroethylene (PTFE) counterweight detection friability,
50 samples, without broken, its friability can reach pharmacopoeial requirements；Use huge sky to send out ZB-lE intelligence to collapse
Xie Yi carries out disintegration experiment, and test sample all can be disintegrated in 10 minutes, and its disintegration time limited reaches medicine
Allusion quotation requirement.
Embodiment 5
By the gelling agent of the sodium chloride of the hydroxypropyl cellulose of 90g and 0.5g and 9.5g (flax in gelling agent
The weight percentage of seed glue and Blackfungus polyhexose ratio is for 10:1) mixing, obtain for preparing Capsules
Raw material, then use tradition to dip in adhesive process and be prepared Capsules, prepare functional plants base
Matter Capsules.Prepared functional plants matrix Capsules is with reference to Chinese Pharmacopoeia version in 2010 two
The method of regulation carries out friability and slaking test, uses polytetrafluoroethylene (PTFE) counterweight detection friability, 50
Sample, without broken, its friability can reach pharmacopoeial requirements；Huge sky is used to send out ZB-lE Intelligent disintegration tester
Carrying out disintegration experiment, test sample all can be disintegrated in 10 minutes, reaches pharmacopeia its disintegration time limited and wants
Ask.
Embodiment 6
By sodium citrate and gelling agent (the gelling agent Central Asia of 4.7g of the hydroxyethyl cellulose of 95g and 0.3g
The weight percentage of fiber crops seed glue and Blackfungus polyhexose ratio is for 6:4) mixing, obtain for preparing Capsules
Raw material, then use tradition to dip in adhesive process and be prepared Capsules, prepare functional plants base
Matter Capsules.Prepared functional plants matrix Capsules is with reference to Chinese Pharmacopoeia version in 2010 two
The method of regulation carries out friability and slaking test, uses polytetrafluoroethylene (PTFE) counterweight detection friability, 50
Sample, without broken, its friability can reach pharmacopoeial requirements；Huge sky is used to send out ZB-lE Intelligent disintegration tester
Carrying out disintegration experiment, test sample all can be disintegrated in 10 minutes, reaches pharmacopeia its disintegration time limited and wants
Ask.
Claims (2)
1. a functional plants matrix Capsules, is characterized in that: described functional plants matrix is hollow
Capsule be by based on the cellulose of matrix prepare with the mixture of flocculation aid and functional gelling agent；
The described mixture that functional gelling agent is Blackfungus polyhexose and flaxseed gum；
Described flocculation aid one in potassium chloride, sodium chloride, potassium citrate and sodium citrate；
The content of the described described cellulose in functional plants matrix Capsules is 80～95wt%,
The content of described flocculation aid is 0.01～0.5wt%, and the content of described functional gelling agent is
4.5～19.99wt%；
The described Blackfungus polyhexose in functional gelling agent with the weight percentage ratio of flaxseed gum is
1:10～10:1.
Functional plants matrix Capsules the most according to claim 1, is characterized in that: described fibre
Dimension element is in hydroxypropyl cellulose, hydroxyethyl cellulose, carboxymethylcellulose calcium and HPMC
One.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410093021.2A CN103861114B (en) | 2014-03-13 | 2014-03-13 | Functional plants matrix Capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410093021.2A CN103861114B (en) | 2014-03-13 | 2014-03-13 | Functional plants matrix Capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103861114A CN103861114A (en) | 2014-06-18 |
| CN103861114B true CN103861114B (en) | 2016-08-24 |
Family
ID=50900497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410093021.2A Active CN103861114B (en) | 2014-03-13 | 2014-03-13 | Functional plants matrix Capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103861114B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104489458A (en) * | 2014-11-29 | 2015-04-08 | 浙江宏辉胶丸有限公司 | Empty capsule adopting coral fungus polysaccharide |
| CN104605227A (en) * | 2015-01-14 | 2015-05-13 | 浙江工业大学 | Hollow capsule with health-care function |
| CN109805351A (en) * | 2019-02-03 | 2019-05-28 | 大连工业大学 | A kind of preparation method of the enriched nutrient salt containing type vitamin A microcapsules |
| CN111449183A (en) * | 2019-06-24 | 2020-07-28 | 广州维汝堂营养健康咨询有限公司 | Probiotic solid beverage with fat reducing function |
| CN111454490B (en) * | 2020-04-14 | 2021-10-22 | 中国科学院化学研究所 | Composition for preparing edible plant plasma membrane and application thereof |
| CN112121172B (en) * | 2020-09-26 | 2022-05-20 | 北京英茂药业有限公司 | Slow-release film coating premix and preparation method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292261A (en) * | 1999-09-28 | 2001-04-25 | 上海大众凌伟生化股份有限公司 | Plant hard capsule and its production process |
| KR100332354B1 (en) * | 1999-10-08 | 2002-04-12 | 장인순 | Dietary fiber from marine products, refining process thereof and the manufacture of functional food containing the dietary fiber |
| CN101023934A (en) * | 2006-12-26 | 2007-08-29 | 北京理工大学 | Method for preparing novel medicine capsule and plant capsule |
| CN101485643B (en) * | 2009-02-25 | 2012-01-11 | 刘松林 | Plant hollow capsule |
| CN102772386B (en) * | 2012-07-30 | 2015-08-19 | 广西南宁汇润生物科技有限公司 | Plant capsule compound adhesive and preparation method thereof |
| CN103432096B (en) * | 2013-08-11 | 2014-12-24 | 重庆衡生药用胶囊有限责任公司 | Hydroxypropyl methylcellulose enteric empty capsule jellied by carrageenan and potassium citrate |
-
2014
- 2014-03-13 CN CN201410093021.2A patent/CN103861114B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103861114A (en) | 2014-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103861114B (en) | Functional plants matrix Capsules | |
| CN103830737B (en) | Functional starch matrix Capsules | |
| Rajeswari et al. | Natural polymers: A recent review | |
| Raizada et al. | Polymers in drug delivery: a review | |
| TWI572360B (en) | Tiny cellulose powder | |
| CN109646423A (en) | Boiomacromolecule nanosphere containing NADH and the preparation method and application thereof | |
| Jabeen et al. | Polysaccharides based biopolymers for biomedical applications: A review | |
| Pahwa et al. | Role of natural polymers in the development of floating drug delivery systems | |
| CN109364091A (en) | Boiomacromolecule nanosphere containing NMN and the preparation method and application thereof | |
| CN104644609B (en) | A kind of feature masticatory pattern soft capsule skin | |
| KR102671429B1 (en) | Easy-to-take particle composition for solid preparation and easy-to-take solid preparation comprising the particle composition | |
| CN111040256A (en) | Raw material composition for preparing starch matrix hollow capsule and starch matrix hollow capsule | |
| Shanmugam et al. | Natural polymers and their applications | |
| WO2015062156A1 (en) | Method for preparing nano-membrane from edible and medical fungi and use thereof | |
| CN107440036A (en) | A kind of Halth-care composition, its preparation and preparation method for improving memory, improving eyesight | |
| CN106074438B (en) | A kind of starch matrix Capsules comprising nonspecific immunity strengthening agent | |
| Maske et al. | Polymers used in mouth dissolving film: A review | |
| CN104173419B (en) | A kind of method that levodopa lozenge is prepared using broad bean flower and broad bean sprouting vegetable | |
| Setia et al. | Applications of gum karaya in drug delivery systems: a review on recent research | |
| CN104548062B (en) | Drug composition containing glutathione and application of drug composition | |
| CN102805741A (en) | Compound micro-capsule and preparation method thereof | |
| CN103800290B (en) | Aminoglucose hydrochloride pellet preparations and preparation method thereof | |
| CN115177597A (en) | Soft capsule and preparation method thereof | |
| Pasha et al. | Evaluation of Modified Date Palm (Phoenix dactylifera L.) Mucilage as a Potential Pharmaceutical Excipient | |
| CN103919119A (en) | Anti-oxidative double-glue reishi shell-broken spore powder and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |