CN107440036A - A kind of Halth-care composition, its preparation and preparation method for improving memory, improving eyesight - Google Patents

A kind of Halth-care composition, its preparation and preparation method for improving memory, improving eyesight Download PDF

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Publication number
CN107440036A
CN107440036A CN201710740182.XA CN201710740182A CN107440036A CN 107440036 A CN107440036 A CN 107440036A CN 201710740182 A CN201710740182 A CN 201710740182A CN 107440036 A CN107440036 A CN 107440036A
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China
Prior art keywords
parts
improving
memory
vitamin
halth
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CN201710740182.XA
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Chinese (zh)
Inventor
刘汝萃
范书琴
张建全
肖晶
姜艳艳
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YUWANG PHARMACEUTICAL CO Ltd SHANDONG PROV
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YUWANG PHARMACEUTICAL CO Ltd SHANDONG PROV
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Priority to CN201710740182.XA priority Critical patent/CN107440036A/en
Publication of CN107440036A publication Critical patent/CN107440036A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of Halth-care composition, its preparation and preparation method for improving memory, improving eyesight.The Halth-care composition includes：60~80 parts of refined fish oil; 10~20 parts of phosphatidylserine; 0.5~2 part of gold needle mushroom extract; 0.1~0.5 part of taurine, 1~10 part of matrimony vine, 1~10 part of Bilberry fruit P.E; 0.004~0.006 part of vitamin A; 0.1~0.3 part of vitamin C, 0.05~0.09 part of zinc gluconate, 0~10 part of auxiliary material.The present invention is also provided comprising the preparation for improving the Halth-care composition for remembering, improving eyesight, and the preparation is soft capsule.The present invention also provides the preparation method of the soft capsule.Composition of raw materials Chinese and Western in the present composition combines reasonable compatibility, has an obvious effect to improving eyesight and memory, and soft capsule preparation has the advantages of bioavailability height, be easy to take, be easy to store and carry.

Description

A kind of Halth-care composition, its preparation and preparation method for improving memory, improving eyesight
Technical field
The invention belongs to a kind of health products, and in particular to a kind of to have the health products group for improving memory, improving visual function Compound, its preparation and preparation method.
Background technology
With the development of society, the study of people, operating pressure are also increasing, it is necessary to which knowledge, the information grasped also are got over Come more, this undoubtedly proposes higher requirement to the memory of people.Also there is report currently for the health products for improving memory Road.CN105030835A provides a kind of capsule and pill for improving memory, and the content is by following raw material：Squalene 20.000- 30.000%, deep sea fish oil 50.000-60.000%, soybean lecithin 1.000-10.000%, vitamin E 0.100-1%, beeswax 1.000-10.000%, zinc lactate 1.000-10.000%；Bioavailability of the present invention is high, is easy to swallow, is easy to store and takes The advantages of band, improve memory, anti-aging, the uncomfortable taste of medicine can be covered.Capsule skin is gelatin in this patent, Gelatin is that the collagenous portion degraded in the connective tissue by animal forms, and has potential virus to carry risk.CN103690627A A kind of auxiliary improvement of memory healthcare function electuary is disclosed, it is especially a kind of that there is auxiliary improvement of memory healthcare function electuary.Should The main component of electuary is：Fish oil 1.0g-500g, phosphatidylserine 1-500g, lecithin 1g-500g, walnut 1g- 500g, jujube 1g-500g, taurine 1.2g-2.0g, median chain triglyceride oil 1g-500g, zinc gluconate 0.01g-0.18g. For the present invention to auxiliary improvement of memory healthcare function, improving depression has remarkable result.Fish oil has fishy smell in this patent, makes electuary Then need to add a large amount of auxiliary materials to cover, and make the increase of consumer's dose.
In addition, as the improvement of people's living standards, electronic product is popularized very much, computer, TV, flat board, mobile phone The life of people is flooded with, transition eye has become universal phenomenon, and the activity that outdoor exercises etc. can loosen eyes is got over Come fewer therefore more and more situations such as caused visual impairment, eyes dry and astringent eye fatigue, people are protected by using health products The consciousness for protecting eyesight is more and more stronger.CN105030877A discloses a kind of health food for alleviating eye fatigue and its preparation side Method, the health food can be effectively improved eyesight by lutein, Bilberry fruit P.E, fish oil, krill oil reasonable compatibility, and And have no toxic side effect.But said composition has no report for the function in terms of improvement memory.
At present, it is simultaneous although for more for the prior art for improving memory and the health products report for improving eyesight There is not been reported for the health products of tool improvement memory and improvement two kinds of functions of eyesight.
The content of the invention
In view of the shortcomings of the prior art, the present invention provide it is a kind of improve memory, improve eyesight Halth-care composition and its Preparation method.The existing function of improving memory of the health products, there is the function of improving eyesight again.
The present invention also provides preparation comprising the Halth-care composition and preparation method thereof, and its formulation is soft capsule.
DHA：That is docosahexaenoic acid；
EPA：That is eicosapentaenoic acid.
Bilberry fruit P.E：It with edible ethanol and deionized water is product made of solvent extracts from cowberry to be, main work( Effect composition is OPC.Market is commercially available.
Gold needle mushroom extract：It is the product extracted with ultrasonic assistant hot water from asparagus, main composition is gold Pin mushroom polysaccharide, flammulina velutipes are the polymers being formed by connecting by the monose of more than 10 by glycosidic bond.Market is commercially available.
In the present invention, " content " is weight ratio.
Technical scheme is as follows：
A kind of Halth-care composition for improving memory, improving eyesight, parts by weight of raw materials composition include：
60~80 parts of refined fish oil, 10~20 parts of phosphatidylserine, 0.5~2 part of gold needle mushroom extract, taurine 0.1 ~0.5 part, 1~10 part of matrimony vine, 1~10 part of Bilberry fruit P.E, 0.004~0.006 part of vitamin A, vitamin C 0.1~0.3 Part, 0.05~0.09 part of zinc gluconate, 0~10 part of auxiliary material.
According to currently preferred, the parts by weight of raw materials composition includes：60~70 parts of refined fish oil, phosphatidylserine 15~20 parts, 0.5~1.5 part of gold needle mushroom extract, 0.2~0.4 part of taurine, 2~8 parts of matrimony vine, 3~9 parts of Bilberry fruit P.E, 0.004~0.005 part of vitamin A, 0.1~0.2 part of vitamin C, 0.06~0.08 part of zinc gluconate, 2~8 parts of auxiliary material.
Most preferably one of scheme of the invention is that the parts by weight of raw materials composition includes：65 parts of refined fish oil, phosphatidyl silk 20 parts of propylhomoserin, 1 part of gold needle mushroom extract, 0.25 part of taurine, 7.75 parts of matrimony vine, 6.75 parts of Bilberry fruit P.E, vitamin A0.004 parts, 0.15 part of vitamin C, 0.07 part of zinc gluconate, 4 parts of auxiliary material.
According to currently preferred, the refined fish oil is rich in DHA and EPA, wherein DHA content>50%, EPA content> 10%.
According to currently preferred, the matrimony vine is powder of the granularity more than 100 mesh.
According in currently preferred, described Bilberry fruit P.E, procyanidin content is 20~30%.Bilberry fruit P.E Can market purchase, can also be prepared by prior art.
According in currently preferred, described gold needle mushroom extract, flammulina velutipes content is 30~55%.Asparagus Extract can market purchase, can also be prepared by prior art.
According to currently preferred, the auxiliary material is beeswax, main to play suspending and make solution uniform.Further preferably , the auxiliary material beeswax parts by weight are 2~10 parts.
A kind of preparation method for the Halth-care composition for improving memory, improving eyesight, including step：
By proportioning, fish oil and beeswax are mixed, is sufficiently stirred and 30~60min is kept at 60~70 DEG C, then add Phosphatidylserine, gold needle mushroom extract, taurine, matrimony vine, Bilberry fruit P.E, vitamin A, vitamin C, zinc gluconate, Stir.
It is a kind of to include the preparation for improving the Halth-care composition for remembering, improving eyesight, it is preferred that the preparation is flexible glue Capsule.
A kind of health products soft capsule for improving memory, improving eyesight, including capsule shells and the content in capsule shells Thing, wherein, using Halth-care composition of the present invention as content.Preferably, the capsule shells by plant gum powder, glycerine and Water forms.Preferably, the parts by weight composition of the capsule shells is 10~40 parts of plant gum powder, 1~20 part of glycerine, water 10~60 Part.Wherein, plant gum powder is the edible rubber powder or/and water solubility cement polysaccharide for coming from plant, such as：Arabic gum, Huang Virgin rubber, pregelatinized starch, konjaku rubber powder, sesbania gum, pulullan polysaccharide etc..
Preferably, the plant gum powder is made up of pulullan polysaccharide, xanthans and Arabic gum.Further preferably, institute It is by pulullan polysaccharide to state plant gum powder：Xanthans：Arabic gum is 10 by weight:1~2:1~1.5 mixes.The plant The good toughness of soft capsule, long-term storage performance are stable made of thing rubber powder.
The improvement memory of the present invention, the preparation method of the health products soft capsule of improvement eyesight, including step：
(1) glue is changed
By proportioning, water and glycerine are well mixed, are heated to 80~100 DEG C, plant gum powder is added and stirs to dissolving completely, Obtain uniform glue mixture；Filter while hot, be incubated 70~80 DEG C, vacuumize the bubble removal in glue, obtain glue；Protect Temperature is stood, standby；
(2) content
By proportioning, fish oil and beeswax are mixed, 30~60min is kept at 60~70 DEG C, adds phosphatidylserine, acupuncture needle Mushroom extract, taurine, matrimony vine, Bilberry fruit P.E, vitamin A, vitamin C, zinc gluconate, stir, and sieving, obtain Capsule 's content, it is standby.
(3) pelleting
The content of the glue of step (1) and step (2) is pressed into soft capsule with pellet press, 12~18h is dried, produces.
Preferably, step (1) filtering is 80-150 eye mesh screens with screen cloth.Vacuumizing described in step (1) be - Carried out under 0.08~-0.01MPa vacuum pressures.
Preferably, the Engler viscosity of glue made from step (1) is no more than 16000Pa ﹒ S, using 14000-16000Pa ﹒ S as Preferably so that enteric coating soft capsule of the present invention rich in toughness, stability is good in long-term storage.The gelatin viscosity is to use grace What family name's viscosimeter measured at 65 DEG C.
Preferably, the sieving described in step (2) was 80-150 mesh sieves.
Preferably, in step (2), in soft capsule drying process, 20~30 DEG C of holding drying room environment temperature, humidity 20~ 40%.
The soft capsule of the present invention, it is 500mg contents/grain that specification, which is made,.It is administered orally, the soft capsule is that enteric solubility is soft Capsule.
In soft capsule preparation process described above, do not have be particularly limited to by state of the art.
The technical characterstic and beneficial effect of the present invention：
1st, improvement memory of the invention, the Halth-care composition of improvement eyesight, with fish oil, phosphatidylserine, asparagus Extract, Bilberry fruit P.E and taurine, matrimony vine, vitamin A, vitamin C, zinc gluconate are compounded, and pass through this nine kinds The synergistic function of component, realize improvement memory while improve the goal of the invention of the Double-function health care product of eyesight.Wherein：
Fish oil is rich in a variety of unrighted acids, and wherein DHA is the part of retina, and supplementing enough DHA can prevent The only generation of retina thrombus, slow down retinosis, alleviation eyes are dry and astringent, protect eyesight；DHA is also Human Fetal Brain Neuron film In main lipid components, and the fatty acid composition that brain cell preferential absorption utilizes, to cranial nerve conduction and the life of cynapse Long hair gives birth to epochmaking effect.Fully fish oil of the supplement rich in DHA can improve the memory of people, be advantageous to improvement again and regard Power.
Phosphatidylserine mainly improves nerve cell function, adjusts the conduction of nerve impulse, promotes brain memory work( Can, there is very strong lipophilicity, can enter brain quickly through vascular barrier after absorption, it is thin to play vascular smooth muscle of releiving Born of the same parents, increase the effect of brain blood supply.
Gold needle mushroom extract can improve the content of protein in cerebral hippocampus tissue, have certain promotion to make to learning and memory With.
Bilberry fruit P.E can obviously improve night vision, very fast to dark reaction, and eye is exposed to after light, can be very fast extensive Diplopia is sensitive, can reduce damage of the light to retina, so as to have necessarily pre- to the eye class disease as caused by light injury Anti- effect.
Taurine is one of free amino acid most abundant in central nervous system, is broken up in the dendron of brain nervous cell Breed with cell in physiological activity, taurine has obvious facilitation.In addition, taurine be also in retina content it is most rich One of rich amino acid, there are the multiple functions such as anti-oxidant, film is stable, regulation osmotic pressure.
Matrimony vine, containing LBP-X, again containing glycine betaine (betaine), atropine, hyoscyamine；Separately contain zeaxanthine (zeaxanthin), wintercherry red pigment (physalein), kryptoxanthin (cryptoxanthin), Scopoletin (scopoletin), Carrotene, riboflavin, nicotinic acid, vitamin B1, B2 and C, aspartic acid, proline, alanine, leucine etc., there is nourishing liver Kidney, strengthening the essence blood-nourishing, improving eyesight disappear screen, the effect to moisten the lung and relieve the cough.
Vitamin A has and can produce rhodopsin effect, is the main component of visual pigment in eye retina.
Vitamin C is protect eyes lenticular clearly and prevents the antioxidant of PVR.
Zinc gluconate is the synthesis for participating in liver and retina vitamin A reductase, is the key enzyme of vision thing synthesis, Other zinc can strengthen the sensitiveness of optic nerve, strengthen light sensation.
Composition of raw materials in the present composition uses Chinese and Western combination principle reasonable compatibility, each component from different aspect, no Have the function that after each component compounding mutually to cooperate with medical knowledge to eyesight and memory improvement, in composition, synergy.
2nd, a kind of improvement memory, the soft capsule for the Halth-care composition for improving eyesight have bioavailability height, are easy to The advantages of taking, being easy to store and carry.The present invention is made capsule shells using plant gum powder and can avoid being existed using animal gelatin Potential virus carry risk.The Engler viscosity for changing the glue obtained after glue is no more than 16000Pa ﹒ S so that enteric of the present invention is soft Capsule rich in toughness, stability is good in long-term storage.
3rd, composition material of the invention is easy to get, and soft capsule dosage form prepares simple, technical maturity, is easy to production and conversion should With.
Embodiment
The present invention is described further with reference to embodiment, but not limited to this.
Raw materials used in embodiment is commercial products.Such as:Bilberry fruit P.E, procyanidin content about 25%；Shaanxi Hong Hao Bioisystech Co., Ltd is on sale.Gold needle mushroom extract, flammulina velutipes content about 40%；The small careless plant science and technology in Xi'an has It is on sale to limit responsible company.
Pellet press used is the soft capsule pellet press of market purchase in embodiment.The specification of soft capsule is in embodiment 500mg/ grains, wherein 500mg are content.
Plant gum powder used is by pulullan polysaccharide in embodiment：Xanthans：Arabic gum is 10 by weight:1:1 is mixed Conjunction forms.
Embodiment 1, a kind of Halth-care composition for improving memory, improving eyesight, raw material components are as follows：
Fish oil 65Kg, phosphatidylserine 20Kg, gold needle mushroom extract 1Kg, taurine 0.25Kg, matrimony vine 7.75Kg, more Tangerine extract 6.75Kg, vitamin A 0.004Kg, vitamin C 0.15Kg, zinc gluconate 0.07Kg, beeswax 4Kg.
A kind of health products soft capsule for improving memory, improving eyesight, using above-mentioned Halth-care composition as content, is pressed It is prepared by following methods：
(1) 12Kg water and 4Kg glycerine are mixed, is heated to 80~90 DEG C, added 12Kg plant gum powders and stir to complete Dissolve entirely, obtain uniform glue mixture；After 100 mesh sieve net filtrations, 70~80 DEG C of temperature is true in -0.08~-0.01Mpa Vacuumized the bubble removal in glue under pneumatics power；Stand, insulation is standby.
(2) 65Kg fish oil and 4Kg beeswaxs are mixed, stirring, 40min are kept at 66 DEG C, add 20Kg phosphatidylserines, 1Kg gold needle mushroom extracts, 0.25Kg taurines, 7.75Kg matrimony vines, 6.75Kg Bilberry fruit P.Es, 0.004Kg vitamin As, 0.15Kg vitamin Cs, 0.07Kg zinc gluconates, are stirred, and are crossed 100 mesh sieves, are obtained capsule 's content, standby.
(3) glue and capsule 's content are pressed into soft capsule with pellet press, keep 20~25 DEG C of drying room environment temperature, wet 18h is dried under the conditions of degree 35~40%, is produced.
Embodiment 2, a kind of Halth-care composition for improving memory, improving eyesight, raw material components are as follows：
Fish oil 70Kg, phosphatidylserine 15Kg, gold needle mushroom extract 1.5Kg, taurine 0.4Kg, matrimony vine 5Kg, cowberry Extract 8Kg, vitamin A 0.004Kg, vitamin C 0.1Kg, zinc gluconate 0.06Kg, beeswax 3Kg.
A kind of health products soft capsule for improving memory, improving eyesight, using above-mentioned Halth-care composition as content, is pressed It is prepared by following methods：
(1) 15Kg water and 3Kg glycerine are mixed, is heated to 90~100 DEG C, added 13Kg plant gum powders and stir to complete Dissolve entirely, obtain uniform glue mixture；After 100 mesh sieve net filtrations, 70~80 DEG C of temperature is true in -0.08~-0.01Mpa Vacuumized the bubble removal in glue under pneumatics power；Stand, insulation is standby.
(2) 70Kg fish oil and 3Kg beeswaxs are mixed, stirring, 50min are kept at 65 DEG C, add 15Kg phosphatidylserines, 1.5Kg gold needle mushroom extracts, 0.4Kg taurines, 5Kg matrimony vines, 8Kg Bilberry fruit P.Es, 0.004Kg vitamin As, 0.1Kg dimension lifes Plain C, 0.06Kg zinc gluconate, is stirred, and is crossed 100 mesh sieves, is obtained capsule 's content, standby.
(3) glue and capsule 's content are pressed into soft capsule with pellet press, keep 20~25 DEG C of drying room environment temperature, wet Under the conditions of degree 30~35%, 15h is dried, is produced.
Embodiment 3, a kind of Halth-care composition for improving memory, improving eyesight, raw material components are as follows：
Fish oil 60Kg, phosphatidylserine 18Kg, gold needle mushroom extract 0.5Kg, taurine 0.3Kg, matrimony vine 7Kg, cowberry Extract 9Kg, vitamin A 0.005Kg, vitamin C 0.2Kg, zinc gluconate 0.09Kg, beeswax 5Kg.
A kind of health products soft capsule for improving memory, improving eyesight, using above-mentioned Halth-care composition as content, is pressed It is prepared by following methods：
(1) 10Kg water and 3.5Kg glycerine are mixed, are heated to 90~100 DEG C, add 11Kg plant gum powders stir to Dissolve completely, obtain uniform glue mixture；After 100 mesh sieve net filtrations, 70~80 DEG C of temperature, in -0.08~-0.01Mpa Vacuumized the bubble removal in glue under vacuum pressure；Stand, insulation is standby.
(2) 60Kg fish oil and the mixing of 5Kg beeswaxs, stirring, 55min are kept at 62 DEG C, add 18Kg phosphatidylserines, 0.5Kg gold needle mushroom extracts, 0.3Kg taurines, 7Kg matrimony vines, 9Kg Bilberry fruit P.Es, 0.005Kg vitamin As, 0.2Kg dimension lifes Plain C, 0.09Kg zinc gluconate, is stirred, and is crossed 100 mesh sieves, is obtained capsule 's content, standby.
(3) glue and capsule 's content are pressed into soft capsule with pellet press, keep 20~25 DEG C of drying room environment temperature, wet 12h is dried under the conditions of degree 25~30%, is produced.
Here is zoopery and clinical trial：
1. improve the zoopery of memory
With soft capsule made from embodiment 1, with the 0 of human body recommended amounts, 10,20 and 30 times of setting animal experiment dosage, divide Not Wei 0.00,0.25,0.50,0.75g/KgBW/d.By 0.2mL/20gBW/d volume gavage mouse, solvent is done with vegetable oil It is made into respective concentration, control group gavage vegetable oil (same volume).Continuous gavage proceeds by water maze test after 30 days.
Water maze laboratory：Body weight 18-22g female mice, it is randomly divided into 0.00,0.25,0.50 and 0.75g/KgBW/d One control group and three tested material dosage groups, every group 12.Water maze test is proceeded by after 30 days to tested material.Training period Between continue to give tested material.Train once daily, continuous 5 days.Mouse is placed near ladder before training in first day, makes its automatic Climb up 3 times, mouse is placed near ladder before training every time later, it is climbed up automatically 1 time.During training in first day, baffle plate is used Kept off extremely at A, training is proceeded by from A points；Second day since at B, this distance train 3 days, to 80% animal in 2min Inside reach terminal；Train from the off within 5th day；(i.e. 5 days arrival ends of each group were finally evaluated with total school grade of 5 days The number of animals that total time, total errors number and each race of point reach home in two minutes, Memory acquisition and memory consolidation).
Experimental result is as follows：
Table 1, the influence (water maze) obtained to mouse memory
*：Compared with control group, P ＜ 0.05
**：Compared with control group, P ＜ 0.01
(P values are probability, statistically represent a kind of method of the significance of difference, and P ＜ 0.05 are notable, and P ＜ 0.01 are non- Chang Xianzhu)
As shown in Table 1, through continuously giving the health products 30 days of mouse various dose, Wu Ge dosage groups group mouse is tidied up The time reached home is considerably less than control group, wherein 0.25,0.50g/KgBW/d dosage groups, compared with control group, difference has aobvious Work property (P ＜ 0.05)；Errors number before each dosage group is reached home is respectively less than control group, and difference has conspicuousness (P ＜ 0.01)。
Water maze test shows that this Halth-care composition plays the role of to improve mouse memory power.
2. improve the clinical trial of eyesight：
General information：100 near-sighted subjects are observed altogether, are randomly divided into test-meal group, control group, each 50.Test-meal group man Property 30, women 20：It is 13~15 years old age, average 14.56 years old.Control group male 29, women 21：Age 13~15 It is year, average 13.92 years old.
Application method：Test-meal group soft capsule made from the present embodiment 1, orally, 3 times a day, 1 tablet each time；Control group is used (placebo is the soft capsule one of the soft capsule that content is vegetable oil, its capsule material and outward appearance and embodiment 1 to placebo Sample), usage amount and the same test-meal group of application method.30 days observing times.
1) ordinary circumstance compares before two groups of observations：
Ordinary circumstance compares (X ± SD) before table 2, observation
Packet Number of cases Eye number The course of disease (year) Far visual acuity Diopter
Test-meal group 50 100 1.41±0.07 4.43±0.21 -0.06±0.07
Control group 50 100 1.43±0.05 4.44±0.22 -0.06±0.08
Indices no significant difference (P ＞ 0.05) before two groups of test-meals as shown in Table 2.
2) eyesight change is compared after two groups of test-meals：
The comparison (X ± SD) that distant vision changes after 3, two groups of test-meals of table
Packet Eye number Before test-meal After test-meal Difference
Test-meal group 100 4.43±0.21 4.72±0.13 0.29±0.08**
Control group 100 4.44±0.23 4.44±0.16## 0.00±0.07##
* test-meals are front and rear itself to compare：Test-meal group P ＜ 0.01；
Test-meal group is compared with control group after ## test-meals：P ＜ 0.01.
Distant vision variation is notable before and after test-meal group test-meal as shown in Table 3；Compared with control group, test-meal group distant vision becomes Change significant difference.Illustrate, this Halth-care composition is advantageous to improve distant vision.
3) comparison of vision improvement rate
The comparison of distant vision improvement rate after table 4, test-meal
Packet Eye number Effectively It is invalid Total effective rate %
Test-meal group 100 70 30 70.0
Control group 100 7 93 7.0##
Test-meal group is compared with control group after ## test-meals：P ＜ 0.01.
As shown in Table 4, compared with control group, the improvement rate of test-meal group distant vision significantly improves.
4) symptom improves situation
Table 5, cardinal symptom improve situation
Control group is indicated in each with (), and symptom improvement rate compares in groups after test-meal：P ＜ 0.01.
As shown in Table 5, compared with control group, the eye of test-meal group is swollen, ophthalmodynia, photophobia, blurred vision, asthenopia, eye are done Puckery improvement rate significantly improves.
5) symptom integral counts.
Table 6, clinical symptoms integration statistics (X ± SD)
Packet Number of cases Before test-meal After test-meal Difference
Test-meal group 50 8.19±2.09 4.58±1.59 3.61±0.5**
Control group 50 8.63±1.72 7.67±1.75 0.96±0.03##
* test-meals are front and rear itself to compare：Test-meal group P ＜ 0.01；
Test-meal group is compared with control group after ## test-meals：P ＜ 0.01.
As shown in Table 6, significantly reduced after test-meal group test-meal with clinical symptoms before test-meal；Compared with control group, test-meal group Clinical symptoms significantly reduce.
6) safety indexes are observed：
Security inspection results contrast (X ± SD) before and after table 7, test-meal
As shown in Table 7, before and after test-meal, the general physical examination of two groups of crowds, blood, routine urianlysis result are in normal model In enclosing.
To the experimental result of eyesight influence, show the health products of the present invention has protective effect to eyes for summary test-meal, Eyesight can be improved, and do not have adverse reaction during test-meal.

Claims (10)

1. a kind of Halth-care composition for improving memory, improving eyesight, parts by weight of raw materials composition include：
60~80 parts of refined fish oil, 10~20 parts of phosphatidylserine, 0.5~2 part of gold needle mushroom extract, taurine 0.1~0.5 Part, 1~10 part of matrimony vine, 1~10 part of Bilberry fruit P.E, 0.004~0.006 part of vitamin A, 0.1~0.3 part of vitamin C, grape 0.05~0.09 part of saccharic acid zinc, 0~10 part of auxiliary material.
2. the Halth-care composition as claimed in claim 1 for improving memory, improving eyesight, it is characterised in that the raw material weight Amount part composition includes：60~70 parts of refined fish oil, 15~20 parts of phosphatidylserine, 0.5~1.5 part of gold needle mushroom extract, ox 0.2~0.4 part of sulfonic acid, 2~8 parts of matrimony vine, 3~9 parts of Bilberry fruit P.E, 0.004~0.005 part of vitamin A, vitamin C 0.1~ 0.2 part, 0.06~0.08 part of zinc gluconate, 2~8 parts of auxiliary material.
3. the Halth-care composition as claimed in claim 1 for improving memory, improving eyesight, it is characterised in that the raw material weight Amount part composition includes：65 parts of refined fish oil, 20 parts of phosphatidylserine, 1 part of gold needle mushroom extract, 0.25 part of taurine, matrimony vine 7.75 parts, 6.75 parts of Bilberry fruit P.E, 0.004 part of vitamin A, 0.15 part of vitamin C, 0.07 part of zinc gluconate, auxiliary material 4 Part.
4. improvement memory, the Halth-care composition of improvement eyesight as described in claim any one of 1-3, it is characterised in that institute State DHA content in refined fish oil>50%, EPA content>10%；Preferably, in described Bilberry fruit P.E, procyanidin content For 20~30%；Preferably, in described gold needle mushroom extract, flammulina velutipes content is 30~55%.
5. improvement memory, the Halth-care composition of improvement eyesight as described in claim any one of 1-4, it is characterised in that institute It is beeswax to state auxiliary material.
6. a kind of health products soft capsule for improving memory, improving eyesight, including capsule shells and the content in capsule shells, Wherein, using the improvement memory described in claim any one of 1-5, the Halth-care composition of improvement eyesight as content.
7. the health products soft capsule as claimed in claim 6 for improving memory, improving eyesight, it is characterised in that the capsule shells It is made up of plant gum powder, G ＆ W；Preferably, the parts by weight composition of the capsule shells is 10~40 parts of plant gum powder, glycerine 1 ~20 parts, 10~60 parts of water.
8. the health products soft capsule as claimed in claim 7 for improving memory, improving eyesight, it is characterised in that the natural plant gum Powder is made up of pulullan polysaccharide, xanthans and Arabic gum；It is preferred that the plant gum powder is by pulullan polysaccharide：Xanthans： Arabic gum is 10 by weight:1~2:1~1.5 mixes.
9. the preparation method of the health products soft capsule of improvement memory, improvement eyesight described in claim any one of 6-8, including step Suddenly：
(1) glue is changed
By proportioning, water and glycerine are well mixed, are heated to 80~100 DEG C, plant gum powder is added and stirs to dissolving completely, obtain Uniform glue mixture；Filter while hot, be incubated 70~80 DEG C, vacuumize the bubble removal in glue, obtain glue；It is incubated quiet Put, it is standby；
(2) content
By proportioning, fish oil and beeswax are mixed, 30~60min is kept at 60~70 DEG C, adds phosphatidylserine, asparagus carries Thing, taurine, matrimony vine, Bilberry fruit P.E, vitamin A, vitamin C, zinc gluconate are taken, is stirred, sieves, obtains capsule Content, it is standby；
(3) pelleting
The content of the glue of step (1) and step (2) is pressed into soft capsule with pellet press, 12~18h is dried, produces；
Preferably, step (1) filtering is 80-150 eye mesh screens with screen cloth, and vacuumizing described in step (1) is -0.08 Carried out under~-0.01MPa vacuum pressures.
10. the preparation method of the health products soft capsule as claimed in claim 9 for improving memory, improving eyesight, wherein, step (1) Engler viscosity of glue made from is 14000-16000Pa ﹒ S, and the gelatin viscosity is to use Engler viscometer at 65 DEG C Measure；Preferably, the sieving described in step (2) was 80-150 mesh sieves；Preferably, in step (2), soft capsule is dried Cheng Zhong, keep 20~30 DEG C of drying room environment temperature, humidity 20~40%.
CN201710740182.XA 2017-08-25 2017-08-25 A kind of Halth-care composition, its preparation and preparation method for improving memory, improving eyesight Pending CN107440036A (en)

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CN109527124A (en) * 2019-01-24 2019-03-29 山西潞安石圪节智华生物科技有限公司 A kind of peony seed oil preparation and preparation method thereof improving memory
CN109731027A (en) * 2019-03-08 2019-05-10 储殷 Facilitate the composition and preparation method thereof of alleviation visual fatigue and xerophthalmia series symptom
CN112294837A (en) * 2020-11-17 2021-02-02 广州三三医药生物科技有限公司 Arginine, taurine and glutamine capsule and preparation method thereof

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CN104840447A (en) * 2015-06-15 2015-08-19 湖北人福药用辅料股份有限公司 Preparation method of pulullan vacant capsules
CN106692166A (en) * 2015-11-18 2017-05-24 珠海宝德润生健康科技有限公司 Composition with memory improving function, and preparation method thereof

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CN102885310A (en) * 2012-10-19 2013-01-23 中科乐仁（北京）科技发展有限公司 Health care food composition capable of assisting in improving memory, and preparation method thereof
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CN108185427A (en) * 2018-02-11 2018-06-22 成都图径生物科技有限公司 Composition for relieving asthenopia containing flake, theanine and phosphatidylserine
CN109527124A (en) * 2019-01-24 2019-03-29 山西潞安石圪节智华生物科技有限公司 A kind of peony seed oil preparation and preparation method thereof improving memory
CN109731027A (en) * 2019-03-08 2019-05-10 储殷 Facilitate the composition and preparation method thereof of alleviation visual fatigue and xerophthalmia series symptom
CN112294837A (en) * 2020-11-17 2021-02-02 广州三三医药生物科技有限公司 Arginine, taurine and glutamine capsule and preparation method thereof

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