CN108185427A - Composition for relieving asthenopia containing flake, theanine and phosphatidylserine - Google Patents

Composition for relieving asthenopia containing flake, theanine and phosphatidylserine Download PDF

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Publication number
CN108185427A
CN108185427A CN201810142340.6A CN201810142340A CN108185427A CN 108185427 A CN108185427 A CN 108185427A CN 201810142340 A CN201810142340 A CN 201810142340A CN 108185427 A CN108185427 A CN 108185427A
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fish
parts
tissue
composition
phosphatidylserine
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魏巍
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Chengdu Map Biotechnology Co Ltd
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Chengdu Map Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D13/00—Finished or partly finished bakery products
    • A21D13/06—Products with modified nutritive value, e.g. with modified starch content
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/42—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/48—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/20—Fish extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to the composition for relieving asthenopia containing flake, theanine and phosphatidylserine, belong to medical and health field.The present invention provides composition for relieving asthenopia, active constituent includes fish eyeball tissue or its extract, fish eye socket tissue or its extract, theanine and phosphatidylserine.Crowd's result on trial shows, the present composition is not only for visual fatigue eyes local symptom, Spirit nerve symptoms of disease caused by more being obviously improved different degrees of visual fatigue, such as absent minded, decrease of memory, alleviate visual fatigue significant effect, have a vast market prospect.

Description

Composition for relieving asthenopia containing flake, theanine and phosphatidylserine
Technical field
The present invention relates to the composition for relieving asthenopia containing flake, theanine and phosphatidylserine, and it is strong to belong to medicine Health field.
Background technology
Visual fatigue is also known as asthenopia, is eye or whole body apparatus factors and spirit based on the subjective symptoms of patient's eye The syndrome that (psychology) factor is interweaved, and the eye disease of dependent, thus commonly referred to as asthenopia syndrome (referring to：1、 Li Fengming China ophthalmology [M] Beijing：People's Health Publisher, 2006,7~8；2nd, the visual fatigues cause of disease such as canal letter grain husk and its Progress [J] the China TCM Ophthalmology magazine for the treatment of, 2003,14 (1)：59~61).Slight visual fatigue can go out after with eye Losing face, portion is sour, the eye symptoms such as swollen, restores quickly after rest；Moderate visual fatigue has apparent eye symptom, influence study and Work；Severe visual fatigue except have apparent eye symptom and be regarded as industry cannot persistently in addition to, also whole bodies such as failure of memory, insomnia Malaise symptoms interfere the vision and quality of life of patient, seriously affect study, work and life (referring to：Horse gets over anthocyanidin drink Material alleviates human trial observation Chinese foods journal [J] .2015 of visual fatigue effect, 8 (15)：8).
A large amount of clinical practice proves, one of ametropia the main reason for being visual fatigue, as long sight, astigmatism, myopia are suffered from Person when not giving correction of refractive errors, sees far or employing larger adjusting when seeing near makes ciliary muscle constant tension cause patient's Accommodative asthenopia.In addition, the factors such as long-time near work, work or reading environment illumination deficiency can result in human eye Adjust nervous, generation visual fatigue.The state of mind and systemic conditions of patient is also closely related with the generation of visual fatigue, stress Greatly, the patient having bad physiques is also easy to produce visual fatigue.
As mobile phone, tablet computer enter people’s lives extensively, crowd's entirety is closely used with constantly extending between at the moment Eye intensity increase, the incidence of each age stratum visual fatigue rapidly increase.Visual fatigue can be improved, and alleviate and brought by visual fatigue Attention, decrease of memory the problems such as product increasingly by consumers.
At present, on the market improve visual fatigue product generally only for blue light damage in itself, eyes local symptom is changed Kind effect unobvious, and other symptoms caused by different degrees of visual fatigue can not be solved, such as absent minded, memory Decline etc..Therefore it provides it is a kind of to visual fatigue eyes local symptom and the apparent product of Spirit nerve symptoms of disease remission effect, become One urgent problem to be solved.
Invention content
The purpose of the present invention is to provide composition for relieving asthenopia.
The present invention provides composition for relieving asthenopia, active constituent includes fish eyeball tissue or its extract, flake Nest tissue or its extract, theanine and phosphatidylserine.
Further, the weight proportion of the active constituent is：10~1000 parts of fish eyeball tissue, fish eye socket tissue 10~ 1000 parts, 20~1000 parts of theanine, 10~1000 parts of phosphatidylserine.
Further, the weight proportion of the active constituent is：100~800 parts of fish eyeball tissue, fish eye socket tissue 100 ~800 parts, 100~400 parts of theanine, 100~600 parts of phosphatidylserine.
Preferably, the weight proportion of the active constituent is：300~600 parts of fish eyeball tissue, fish eye socket tissue 300~ 600 parts, 200~400 parts of theanine, 200~500 parts of phosphatidylserine.
It is further preferred that the weight proportion of the active constituent is：Fish eyeball tissue：Fish eye socket tissue：Theanine：Phosphorus Acyl serine=1：1：1：1.
The weight proportion is in terms of fish eyeball tissue, fish eye socket tissue fresh goods weight.
Further, the fish eyeball tissue or fish eye socket tissue are selected from yaito tuna, tuna, stripped tuna, scad, Rofe Fish, ray fish, gadus, mackerel, hard squama perch, smelt, salmon, sand lance, red coat, anglerfish, great white shark, gurnet, it is bright too Fish, east perch, carp, crucian, black carp, marlin, red porgy, grey mullet, Spanish mackerel, catfish, silverfish, saury, sunfish, black porgy, Hairtail, zingel, loach, snakeheaded fish, is aunt fish, east Peristedion, swordfish, fugu obscurus, yellowfin tuna, ash at mandarin fish Mackerel shark, yellow croaker, filefish, sole, mouse fish, hilsa herring, Hei Jun fishes, sardine, spot fin chromide, atka mackerel, tilefiss, eel The eyeball tissue or orbital structures of one or more kinds of fish in fish, butterfish, spotted maigre.
Further, the extract is water extract or alcohol extract.
Further, active constituent is also comprising anthocyanidin, astaxanthin, procyanidine, lutein, lutein ester, (3R, 3' R one or more kinds of mixture in)-dihydroxy-beta carotene.
Further, active constituent further includes 10~1000 parts of anthocyanidin；It is preferred that 20~500 parts.
Further, active constituent further includes 1~800 part of procyanidine；It is preferred that 1~500 part.
Further, active constituent further includes 1~250 part of astaxanthin；It is preferred that 4~25 parts.
Further, active constituent further includes 0.6~25 part of lutein and/or lutein ester；It is preferred that 1~25 part.
Further, active constituent further includes 0.2~10 part of (3R, 3'R)-dihydroxy-beta carotene；It is preferred that 1~10 Part.
The anthocyanidin from blueberry, cowberry, european cranberry, grape, purple sweetpotato, blood orange, red cabbage, eggplant, cherry, It is one or two kinds of in the red certain kind of berries, strawberry, mulberries, hawthorn, morning glory, matrimony vine, elder, red, blackcurrant, purple carrot and red cabbage More than.
The procyanidine from grape pip, grape, hawthorn, peanut, ginkgo, blueberry, black soya bean, rape, oil tea, rice, Sorghum, cocoa, broad bean, hyacinth bean, lichee, sea-buckthorn, apple, blackberry, blueberry, wild strawberry, longan, cowberry, arrow-leaved oleaster, european cranberry, persimmon, mountain Bamboo, pomegranate, cypress, pine tree, white popinac, silver birch, eucalyptus, uncaria Chinese white poplar, Chinese cassia tree, thick grass, tealeaves, grapevine, mountain radix scrophulariae, Hypericum perforatum bay, eucalyptus, rose, leads a cow, is purple plague purpura water spinach, red clover, water lily, crotons, garden burnet, purple sweetpotato, elegant jessamine, big It is one or more kinds of in yellow, different leaf fogfruit.
Further, the composition is the active constituent of each weight proportion, adds in acceptable auxiliary material or auxiliary Food, health products or the drug that property ingredient is prepared.
Further, the food, health products or drug are oral form.
Further, the food or health products are candy, beverage, biscuit, bread, jelly or dietary supplements.
The present invention provides the preparation methods of the composition, include the following steps：The active constituent of each weight proportion is taken, Add in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
The present invention provides purposes of the composition in the food for alleviating visual fatigue, health products or drug is prepared.
Further, the food, health products or drug have eyes local symptom and/or spirit caused by alleviation visual fatigue The effect of nervous symptoms.
Further, the eyes local symptom for eye is ached, eye is swollen, photophobia, blurred vision, eye are dry and astringent, foreign body sensation or It sheds tears.
Further, the Spirit nerve symptoms of disease is decreased attention, failure of memory, anxiety or insomnia.
The present invention provides composition for relieving asthenopia.Crowd's result on trial show the present composition not only for Visual fatigue eyes local symptom, Spirit nerve symptoms of disease caused by more being obviously improved different degrees of visual fatigue, such as attention not Concentration, decrease of memory etc. alleviate visual fatigue significant effect, have a vast market prospect.
Specific embodiment
The raw material that is used in the specific embodiment of the invention, equipment are known product, are obtained by buying commercial product.
The present invention provides composition for relieving asthenopia, active constituent includes fish eyeball tissue or its extract, fish Orbital structures or its extract, theanine and phosphatidylserine.
The construction of flake eyeball is relatively simple, most fish without eyelid and eyeball is completely exposed, flake eyeball appearance be in ellipsoid Shape, in the eye socket surrounded by supra-orbital, several socket of the eye ossiculums and soft cranium.The flake of general ocean fish is divided into from outside to inside under light microscopic Corneo-scleral layer, iris-choroid layer, crystalline lens and layer of retina.It is transparent cornea before eyeball, remaining is brownish black Sclera.It is made of on the inside of eyeball muscle, optic nerve, blood vessel and cartilage (optic stalk).The size of flake eyeball and it daily contacted Light be relative.The upper strata of water or the fish in middle level are moved in, they have normal eyes, such as carp, crucian, yellow croaker Fish.And the fish of 300~1500 meters of depths are lived in, because light here is extremely weak, general eyes are all bigger, such as big eye porgy Fish.Flake eyeball rich in vitamin, active peptides, amino acid, carbohydrate, various trace elements (calcium, phosphorus, iron, zinc etc.) and including A variety of unrighted acids including omega-fatty acid, these substances have comprehensive beneficial effect to the metabolism of eyes.
Fish eye socket tissue is the musculature and adipose tissue being located at around flake eyeball, wherein, fish eye socket adipose tissue (eye Nest fat is one kind of the structural fatty in eyeball behind, is existed for protection optic nerve, plays protection eyeball from Gao Shui Weigh harmful buffer effect wounded, while again as DHA supply sources necessary to brain, retina) fat content height, especially ocean fish Containing a large amount of polyunsaturated fatty acid in fish eye socket adipose tissue, ω -3 highly unsaturated fatty acids series therein is (mainly It is DHA, EPA) there is special physiological function.DHA is nervous system growth and a kind of essential element maintained, is brain and regards The important composition ingredient of nethike embrane, content is up to 20% in human brain cortex, and proportion is maximum in eyes regard film, accounts for about 50%.DHA is known as " docosapentaenoic acid " and " clever motive power ", but human body itself cannot synthesize DHA, can only be taken the photograph from food It takes.
At present, the report that rarely seen fish eyeball tissue, fish eye socket tissue or its extract are used alone, purposes are mainly anti-blood Bolt increases and regards improving eyesight etc., but there is not yet fish eyeball tissue or fish eye socket tissue alleviate the correlative study of visual fatigue effect, more have no by The report that the two is applied in combination.
For the present invention by crowd's probationary certificate, fish eyeball tissue, fish eye socket tissue are respectively provided with significant alleviation visual fatigue Effect aches to eye caused by visual fatigue, eye is swollen, photophobia, blurred vision, foreign body sensation, the symptoms such as shed tears can play centainly The mitigation of degree, moreover, by after fish eyeball tissue and fish eye socket stitch combinations use, the beneficial eye ingredient that the two is rich in is in work( Complementation has been obtained in effect, synergistic effect can have been played so that the effect for alleviating visual fatigue is further promoted.
In addition, active constituent theanine and phosphatidylserine are additionally added in the present composition.
Theanine can inhibit the toxicity of glutamic acid, protect neuron；Have the function of to promote α waves in E.E.G to generate, from And cause light, pleasant feeling, alleviate depression and anxiety；Blood pressure lowering；Promote attention concentrate, promote reaction speed and Accuracy.
Phosphatidylserine is clinically mainly used for treating brain aging, is more drawn in recent years with " brain specificity nutriment " Play everybody extensive concern.70% is more up in nerve fiber, is played a significant role, maintenance to nerve cell is repaiied Multiple and function plays an important roll.Research shows that supplement phosphatidylserine can slow down even reverse it is dull-witted or with aging phase The study of pass, mood, memory, decreased attention.Studies have found that repetition or long-term intraperitoneal injection and oral phosphatidylserine Afterwards, the cumulative function of the PS (phosphatidylserine) in brain is infiltrated through on a small quantity, observes changing for many behaviors and neurotransmitter Become.Also studies have found that phosphatidylserine has cognitive defect positive therapeutic effect.
The present invention is added to by regarding theanine and phosphatidylserine as active constituent containing flake ball and fish eye socket Product in, can significantly accelerated flake to the remission effect of eyes local symptom, can be effective after taking 1 day, and long-term Flake is relatively applied alone more preferably to the remission effect of eyes local symptom after taking.In addition, after adding in theanine and phosphatidylserine The visual fatigues constitutional symptom such as attention and memory can also be obviously improved, including that can mitigate or alleviate under attention and memory Drop problem, trier is generally reflected to be alleviated significantly using rear anxiety, and the sleeping problems caused by asthenopia are also relieved.
The present invention is improving efficacy of relieving visual fatigue simultaneously, enables a consumer to most experience effect soon, significantly improves consumption Person uses wish, so as to which the alleviation for making visual fatigue becomes easily simple.
The flakes ball such as 1 yaito tuna of embodiment, tuna, stripped tuna, scad, Tilapia mossambica extract (using DHA as index components) Manufacture
Feedstock processing：Fresh ocean fish flake (eyeball tissue) is taken to be eluted with water, after draining, in the citric acid of 0.05-0.1% 10-30min is impregnated in solution, moisture content is dried in 40-70 DEG C less than 4%, then be crushed to the ocean fish powder of 100-200 mesh；
Enzymolysis：Buffer solution is added with 6mol/L hydrochloric acid tune pH value to be 4-6 ocean fish powder after processing, add in mass fraction 0.1-1.0%, enzyme activity 3.0 × 104The papain of u/g and mass fraction 0.5-1.5%, enzyme activity 1.0 × 104The fiber of u/g Plain enzyme, in 40-60 DEG C of stirring enzymolysis 1-2h, later with 0.5mo1/L sodium hydroxide tune pH to neutrality；
Vacuum extraction：Obtained ocean fish enzymolysis liquid is placed in vacuum extraction equipment, controls vacuum degree 85-90KPa, temperature 40-60 DEG C is extracted 1-2 hours, while enzyme deactivation, obtains extracting solution；
Separation：Extracting solution in 6000rpm is centrifuged 20 minutes, collects supernatant；
Concentration：Obtained liquid is placed in vacuum concentration equipment, controls vacuum degree 85-90KPa, 40-60 DEG C of temperature is dense The l/5-1/3 of original volume is reduced to, obtains DHA concentrates.
The fish eye sockets extracts such as 2 yaito tuna of embodiment, tuna, stripped tuna, scad, Tilapia mossambica (using DPA, EPA and DHA as Index components) manufacture
Eye socket after ocean fish is processed is cleaned, and is 1 with solid-liquid weight ratio：The ratio of 1-1.2 adds in water, regrinds pulp and obtains To homogenate；Homogenate organic solvent is taken to extract 1-3 times, the ratio between organic solvent and homogenate volume are 1：1.2-1.5 collect extraction Liquid, obtains that the extract liquor containing DPA, EPA and DHA grease is spare, and the organic solvent refers to petroleum ether or ether；Extract liquor returns Organic solvent is received, the fish oil containing DPA, EPA and DHA is obtained, the 0.3mol/L sodium methoxide isometric with fish oil is taken to mix, room temperature item Nitrogen charging stirring after ten minutes, adjusts pH value to 7.0-7.2, recycles methanol, obtain the fish oil of esterification under part；To esterification fish oil Carry out molecular distillation, including degassing, pre- thermal distillation and distillation three technical steps, wherein de-airing step in 20-30 DEG C of temperature, be System pressure is de-gassed under conditions of 1-2mbar；Distilation steps are preheated in fish oil with 15-20 kgs/hour of charging rate It is sent into pre-thermal level distiller, in 170-200 DEG C of temperature, system pressure 0.001-0.01mbar, knifing spinner velocity 150-250 It is distilled under conditions of rev/min；Distilation steps are sent into 5-20 kgs/hour of charging rate in distiller, in temperature 250- 350 DEG C, system pressure 0.001-0.01mbar, distill under conditions of 150-250 revs/min of knifing spinner velocity, collect 290- Fraction at 310 DEG C is to get to the compound containing EPA, DHA and DPA of higher degree.
The preparation of 3 present composition of embodiment
Raw material weight proportioning of soup processed：Fish eye socket tissue crushed material or 200-600 parts of extract (in terms of fresh goods weight), flake ball group Knit crushed material or 200-600 parts of extract (in terms of fresh goods weight), 200~400 parts of theanine, phosphatidylserine 200~500 Part, 50~200 parts of anthocyanidin (or astaxanthin:4~12 parts and/or 1-200 parts of procyanidine), (3R, 3'R)-dihydroxy-β- 5~15 parts of 1-5 parts of carrotene, lutein and/or lutein ester.
Preparation method：
1st, by weight ratio by fish eye socket tissue crushed material or extract, flake ball tissue crushed material or extract, tea ammonia Acid, phosphatidylserine, anthocyanidin (or astaxanthin and/or procyanidine), (3R, 3'R)-dihydroxy-beta carotene, lutein Ester adds in syrup and stirs evenly after mixing.
2nd, hard, toffee, sandwich, crisp matter, burnt odor (too prince wife), inflation, gel, glue can be made in injection molding on demand after being cooled and shaped The confectionery formats such as base, tabletting, liquid, diaphragm, fancy and chocolate and chocolate, substitute of cocoa fat chocolate and Dai Ke It can the pan works such as fat chocolate, jelly (fruit juice type, fruit pulp type, fruit-flavor type, milk type etc.).
The preparation of 4 present composition of embodiment
Raw material weight proportioning of soup processed：Fish eye socket tissue crushed material or 200-500 parts of extract (in terms of fresh goods weight), flake ball group Knit crushed material or 200-500 parts of extract (in terms of fresh goods weight), 200~400 parts of theanine, phosphatidylserine 200~500 Part, 50~200 parts of anthocyanidin (or astaxanthin:4~12 parts and/or 1-300 parts of procyanidine), (3R, 3'R)-dihydroxy-β- 1~25 part of 1-10 parts of carrotene, lutein and/or lutein ester.
Preparation method：Select fish eye socket tissue crushed material or extract, flake ball tissue crushed material or extract, tea ammonia Acid, gamma aminobutyric acid, anthocyanidin (or procyanidine and/or haematococcus pluvialis extract), (3R, 3'R)-dihydroxy-β-carrot The raw material mixing of element, lutein ester, add in required processing water and 30-45 liquid milks be sufficiently stirred, dissolved, homogeneous, Matter pressure is 25Mpa, then carries out ultra-high temperature sterilization, aseptic packaging, through being put in storage after the assay was approved.
The preparation of 5 present composition of embodiment
Raw material weight proportioning of soup processed：Fish eye socket tissue crushed material or 200-600 parts of extract (in terms of fresh goods weight), flake ball group Knit crushed material or 200-600 parts of extract (in terms of fresh goods weight), 200-500 parts of phosphatidylserine, 50~200 parts of anthocyanidin (or astaxanthin:4~12 parts and/or 1-300 parts of procyanidine), (3R, 3'R)-dihydroxy -0.2-10 parts of beta carotene, leaf 0.6~25 part of flavine and/or lutein ester.
Preparation method：Select fish eye socket tissue crushed material or extract, flake ball tissue crushed material or extract, tea ammonia Acid, blueberry extract, stir evenly, ozone sterilization is filling, can directly take after mixing it with water or be added to other food as functional auxiliary material In.
Beneficial effects of the present invention are proved below by way of test example.Flake ball tissue extract use as described below is according to reality The Tilapia mossambica eyeball tissue extract of 1 method of example preparation is applied, fish eye socket tissue extract uses what is prepared according to 2 method of embodiment Tilapia mossambica eye socket tissue extract.
1 fish eyeball tissue of test example and/or fish eye socket tissue alleviate visual fatigue and its related indication observation on probation
3 test groups are set, take flake ball tissue extract, fish eye socket tissue extract as shown in table 2 respectively, in bracket It represents the weight of corresponding fresh fish eyeball tissue, fish eye socket tissue, the big opaque capsule such as is loaded into, for asthenope Examination clothes continuously take 60 days (table 2, which corresponds to, daily to be measured), observe trial effect.
According to《Visual fatigue diagnosis and treatment Consensus of experts》(2014) are diagnosed as visual fatigue patient 144, and symptom hinders including vision Hinder：Near work or reading be not lasting, temporary blurred vision or ghost image occurs；Ophthalmic uncomfortable：Eye is swollen, ophthalmodynia, eye are burnt Feel, shed tears, eye is itched, eye foreign body sense and eye socket pain.Constitutional symptom：Fatiguability has a headache, is dizzy, failure of memory, under memory Drop, anxiety, irritated and other neurosiss symptoms.Age 18-65 Sui, random point 3 groups.Medicine prison guarantorization is eaten according to state [2012] No. 107《Alleviate visual fatigue function evaluation methods》Visual fatigue measuring scale is worked out, is shown in Table 1, calculates before taking, take 60 Its integration reduced rate：Total mark × 100% before (total mark after total mark-treatment before treatment)/treatment, post treatment integral reduced rate >=30% is effective.Symptom integral improves efficient statistical result and is shown in Table 2.
1 visual fatigue measuring scale of table (sxemiquantitative integration method)
Note：" random thoughts " refer to 1-2 times/2 days；" when have " refers to 1-3 times/day；" frequent " refers to>3 times/day
2 symptom integral improvement rate statistical result of table
Crowd's result on trial is shown：Fish eyeball tissue, fish eye socket tissue are respectively provided with the significant effect for alleviating visual fatigue, right Eye caused by visual fatigue is ached, eye is swollen, photophobia, blurred vision, foreign body sensation, the symptoms such as shed tears can play it is a degree of slow Solution acts on, moreover, by after fish eyeball tissue and fish eye socket stitch combinations use, the beneficial eye ingredient that the two is rich in obtains in effect Complementation can play synergistic effect so that the effect for alleviating visual fatigue further promoted.
2 present composition of test example alleviates visual fatigue and its related indication observation on probation
9 test groups are set, take flake ball tissue extract, fish eye socket tissue extract, tea ammonia as shown in table 3 respectively Acid, phosphatidylserine, bracket is interior to represent corresponding fresh fish eyeball tissue, fish eye socket tissue, theanine, phosphatidylserine Weight, the big opaque capsule such as be loaded into, try to take for asthenope, continuously taking 60 days, (table 3 corresponds to daily Amount), observe trial effect.
According to《Visual fatigue diagnosis and treatment Consensus of experts》(2014) are diagnosed as visual fatigue patient 216, and symptom hinders including vision Hinder：Near work or reading be not lasting, temporary blurred vision or ghost image occurs；Ophthalmic uncomfortable：Eye is swollen, ophthalmodynia, eye are burnt Feel, shed tears, eye is itched, eye foreign body sense and eye socket pain.Constitutional symptom：Fatiguability has a headache, is dizzy, failure of memory, under memory Drop, anxiety, irritated and other neurosiss symptoms.Age 18-65 Sui, random point 9 groups.Medicine prison guarantorization is eaten according to state [2012] No. 107《Alleviate visual fatigue function evaluation methods》Visual fatigue measuring scale is worked out, is shown in Table 1.Constitutional symptom carries out individual event Scoring：Decreased attention evaluates (0 point：It can adhere to being absorbed in work or learn 30 minutes；1 point：Occasionally there is decreased attention；2 points：When There is decreased attention；3 points：Often there is decreased attention)；Decrease of memory evaluates (0 point：Yesterday, thing can all be recalled；1 point： Occasionally there is decrease of memory；2 points：When have decrease of memory；3 points：Often there is decrease of memory)；Note：" occasionally having " refers to 1-2 times/2 My god；" when have " refers to 1-3 times/day；" frequent " refers to>3 times/day.Calculating take before, take 60 days integration reduced rate：(treatment Total mark after preceding total mark-treatment)/treatment before total mark × 100%, post treatment integral reduced rate >=30% is effective.Symptom Integration improves efficient statistical result and is shown in Table 3.
3 symptom integral of table improves efficient statistical result
Test group 1 is only added to flake ball and fish eye socket tissue extract, and result on trial shows that it has significant alleviate The effect of visual fatigue eyes local symptom, improvement rate reaches 87% after taking 60 days, but it is slower to work, and takes 1 day effective percentage only It is 20%.
Test group 2~9 is added to active constituent phosphatidyl silk ammonia on the basis of flake ball and fish eye socket tissue extract Acid and theanine, the as a result significantly accelerated remission effect to eyes local symptom can be effective after taking 1 day, and long-term To the remission effect of eyes local symptom compared with test group 1 more preferably (contrast test group 1,2 is understood) after taking.In addition, add in phosphatide The test group of acyl serine and theanine can also be obviously improved attention and memory situation.
From test group 2~9 as can be seen that fish eyeball tissue, fish eye socket tissue and theanine, phosphatidylserine are in this hair (i.e. 10~1000 parts of fish eyeball tissue, 10~1000 parts of fish eye socket tissue, theanine 20~1000 in the ratio range of bright restriction Part, 10~1000 parts of phosphatidylserine) it is applied in combination, the apparent effect for alleviating visual fatigue can be played, influence is regarded The eyes local symptom and constitutional symptom of tired crowd has obvious curative effects.Wherein, it is preferably in a proportion of：Fish eyeball tissue 300~ 600 parts, 300~600 parts of fish eye socket tissue, 200~400 parts of theanine, 200~500 parts of phosphatidylserine.

Claims (14)

1. composition for relieving asthenopia, it is characterized in that：Active constituent includes fish eyeball tissue or its extract, fish eye socket tissue Or its extract, theanine and phosphatidylserine.
2. composition as described in claim 1, it is characterized in that：The weight proportion of the active constituent is：Fish eyeball tissue 10 ~1000 parts, 10~1000 parts of fish eye socket tissue, 20~1000 parts of theanine, 10~1000 parts of phosphatidylserine.
3. composition as claimed in claim 2, it is characterized in that：The weight proportion of the active constituent is：Fish eyeball tissue 100 ~800 parts, 100~800 parts of fish eye socket tissue, 100~400 parts of theanine, 100~600 parts of phosphatidylserine；Preferably, The weight proportion of the active constituent is：300~600 parts of fish eyeball tissue, 300~600 parts of fish eye socket tissue, theanine 200 ~400 parts, 200~500 parts of phosphatidylserine；It is further preferred that the weight proportion of the active constituent is：Flake ball group It knits：Fish eye socket tissue：Theanine：Phosphatidylserine=1：1：1：1.
4. the composition as described in claims 1 to 3 any one, it is characterized in that：The fish eyeball tissue or fish eye socket tissue Selected from yaito tuna, tuna, stripped tuna, scad, Tilapia mossambica, ray fish, gadus, mackerel, hard squama perch, smelt, salmon, beautiful muscle Fish, red coat, anglerfish, great white shark, gurnet, walleye pollack, east perch, carp, crucian, black carp, marlin, red porgy, grey mullet, Spanish mackerel Fish, silverfish, saury, sunfish, black porgy, hairtail, mandarin fish, zingel, loach, snakeheaded fish, cries aunt fish, east Huang triangular bream at catfish Fu, swordfish, fugu obscurus, yellowfin tuna, mako shark, yellow croaker, filefish, sole, mouse fish, hilsa herring, black Jun fishes, Sha Ding The eyeball group of one or more kinds of fish in fish, spot fin chromide, atka mackerel, tilefiss, sea eel, butterfish, spotted maigre It knits or orbital structures.
5. the composition as described in claims 1 to 3 any one, it is characterized in that：The extract is water extract or alcohol extract.
6. composition as claimed in any one of claims 1 to 5, wherein, it is characterized in that：Active constituent is also green comprising anthocyanidin, shrimp One or more kinds of mixing in element, procyanidine, lutein, lutein ester, (3R, 3'R)-dihydroxy-beta carotene Object.
7. the composition as described in claim 1~6 any one, it is characterized in that：It is the active constituent of each weight proportion, adds in Food, health products or the drug that acceptable auxiliary material or complementary ingredient are prepared.
8. composition as claimed in claim 7, it is characterized in that：The food, health products or drug are oral form.
9. composition as claimed in claim 8, it is characterized in that：The food or health products are candy, beverage, biscuit, bread, Jelly or dietary supplements.
10. the preparation method of composition described in claim 1~9 any one, it is characterized in that：Include the following steps：It takes each heavy Measure the active constituent of proportioning, add in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
11. composition described in claim 1~9 any one is in the food for alleviating visual fatigue, health products or drug is prepared Purposes.
12. purposes as claimed in claim 11, it is characterized in that：The food, health products or drug, which have, alleviates visual fatigue institute The effect of causing eyes local symptom and/or Spirit nerve symptoms of disease.
13. purposes as claimed in claim 12, it is characterized in that：The eyes local symptom is eye is ached, eye is swollen, photophobia, is regarded Object obscures, eye is dry and astringent, foreign body sensation or sheds tears.
14. purposes as claimed in claim 12, it is characterized in that：The Spirit nerve symptoms of disease is decreased attention, memory subtracts It moves back, anxiety or insomnia.
CN201810142340.6A 2018-02-11 2018-02-11 Composition for relieving asthenopia containing flake, theanine and phosphatidylserine Pending CN108185427A (en)

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Application publication date: 20180622