CN108324705A - Composition for relieving asthenopia containing theanine, γ-aminobutyric acid and anthocyanidin - Google Patents
Composition for relieving asthenopia containing theanine, γ-aminobutyric acid and anthocyanidin Download PDFInfo
- Publication number
- CN108324705A CN108324705A CN201810146487.2A CN201810146487A CN108324705A CN 108324705 A CN108324705 A CN 108324705A CN 201810146487 A CN201810146487 A CN 201810146487A CN 108324705 A CN108324705 A CN 108324705A
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- composition
- anthocyanidin
- parts
- aminobutyric acid
- theanine
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The present invention relates to the composition for relieving asthenopia containing theanine, gamma aminobutyric acid and anthocyanidin, belong to medical and health field.The present invention provides composition for relieving asthenopia, active constituent includes theanine, gamma aminobutyric acid and anthocyanidin.Crowd's result on trial shows, the present composition can more be obviously improved Spirit nerve symptoms of disease caused by different degrees of visual fatigue, such as absent minded, decrease of memory not only for visual fatigue eyes local symptom, alleviate visual fatigue significant effect, has a vast market foreground.
Description
Technical field
The present invention relates to the composition for relieving asthenopia containing theanine, γ-aminobutyric acid and anthocyanidin, and it is strong to belong to medicine
Health field.
Background technology
Visual fatigue is also known as asthenopia, is eye or whole body apparatus factors and spirit based on the subjective symptoms of patient's eye
The syndrome that (psychology) factor is interweaved, not independent eye disease, thus commonly referred to as asthenopia syndrome (referring to：1、
The Beijing Li Fengming China ophthalmology [M]：People's Health Publisher, 2006,7~8；2, the visual fatigues cause of disease such as canal letter grain husk and its
Progress [J] the China TCM Ophthalmology magazine for the treatment of, 2003,14 (1)：59~61).Slight visual fatigue can go out after with eye
Losing face, portion is sour, the eye symptoms such as swollen, restores quickly after rest；Moderate visual fatigue has apparent eye symptom, influence study and
Work；Severe visual fatigue except have apparent eye symptom and be regarded as industry cannot persistently in addition to, also whole bodies such as failure of memory, insomnia
Malaise symptoms interfere the vision and quality of life of patient, seriously affect study, work and life (referring to：Horse gets over anthocyanidin drink
Chinese foods journal [J] .2015,8 (15) are observed in the human trial that material alleviates visual fatigue effect：8).
A large amount of clinical practice proves, one of ametropia the main reason for being visual fatigue, as long sight, astigmatism, myopia are suffered from
Person sees far when not giving correction of refractive errors or employing larger adjusting when seeing close makes ciliary muscle constant tension cause patient's
Accommodative asthenopia.In addition, the factors such as long-time near work, work or reading environment illumination deficiency can result in human eye
Adjust nervous, generation visual fatigue.The state of mind and systemic conditions of patient is also closely related with the generation of visual fatigue, stress
Greatly, the patient having bad physiques is also easy to produce visual fatigue.
As mobile phone, tablet computer enter people’s lives extensively, crowd's entirety is closely used with constantly extending between at the moment
Eye intensity increases, and the incidence of each age stratum visual fatigue rapidly increases.Visual fatigue can be improved, and alleviate and brought by visual fatigue
Attention, decrease of memory the problems such as product increasingly by consumers.
Currently, the product for improving visual fatigue on the market changes eyes local symptom generally only for blue light damage itself
Kind effect unobvious, and other symptoms caused by different degrees of visual fatigue can not be solved, such as absent minded, memory
Decline etc..Therefore it provides it is a kind of to visual fatigue eyes local symptom and the apparent product of Spirit nerve symptoms of disease remission effect, become
One urgent problem to be solved.
Invention content
The purpose of the present invention is to provide composition for relieving asthenopia.
The present invention provides composition for relieving asthenopia, active constituent includes theanine, γ-aminobutyric acid and cyanine
Element.
Further, the weight proportion of the active constituent is：20~1000 parts of theanine, γ-aminobutyric acid 10~
1000 parts, 10~1000 parts of anthocyanidin.
Further, the weight proportion of the active constituent is：100~400 parts of theanine, γ-aminobutyric acid 70~500
Part, 20~500 parts of anthocyanidin.
Preferably, the weight proportion of the active constituent is：200~400 parts of theanine, γ-aminobutyric acid 100~300
Part, 100~200 parts of anthocyanidin.
It is further preferred that the weight proportion of the active constituent is：Theanine：γ-aminobutyric acid：Anthocyanidin=(1~
2)：1：1.
Further, the anthocyanidin from blueberry, cowberry, european cranberry, grape, purple sweetpotato, blood orange, red cabbage,
In eggplant, cherry, the red certain kind of berries, strawberry, mulberries, hawthorn, morning glory, matrimony vine, elder, red, blackcurrant, purple carrot and red cabbage
It is one or more kinds of.
The preferred blueberry source of anthocyanidin of the present invention, Blueberry, which contains, prevents cranial nerve aging, enhancing cardiac function, improving eyesight
And the unique effects substance such as anticancer, therefore one of five big healthy food of the mankind is classified as by international food and agricultural organization.European extensive utilization
Pharmaceutical products standard using 25% anthocyanidin content as standard.It is strong that daily 80-160mg extracts are recommended for improvement eye
Health, and 160-240mg can then treat eye disease.Blueberry extract does not have any known side effect, and excessive intake meeting
It is discharged with urine and bile rapidly.Two pigment of cyanine contained in blueberry has effects that activate retina, can strengthen eyesight, prevents
Only eyeball fatigue.Blueberry primary efficacy：Protect eyesight, prevent blindness, green light is bright, cataract, retinal hemorrhage, improve myopia,
Macular degeneration, diabetic keratopathy nethike embrane disease, retinitis pigmentosa and yctalopia etc..Anthocyanidin in blueberry can promote retina thin
The regeneration of visual purple in born of the same parents can prevent laser high myopia and detached retina, and can promote eyesight.France uses anthocyanidin for many years
Diabetic retinopathy is treated, eyes capillary hemorrhage is significantly reduced, improves eyesight.Anthocyanidin is also used for preventing sugar
Urinate the complication after patient's cataract operation.Anthocyanidin can mitigate damage of the free radical to eye lens, alleviate because it is long when
Between the eye strain that brings of operation computer or driving etc. and damage.
Further, active constituent further includes DHA, lutein, lutein ester, (3R, 3'R)-dihydroxy-beta carotene
The mixture of middle one or more.
Further, active constituent further includes 10~1000 parts of DHA.
Further, active constituent further includes 0.6~25 part of lutein and/or lutein ester.
Further, active constituent further includes 0.2~10 part of (3R, 3'R)-dihydroxy-beta carotene.
Further, the composition is the active constituent of each weight proportion, and acceptable auxiliary material or auxiliary is added
Food, health products or the drug that property ingredient is prepared.
Further, the food, health products or drug are oral form.
Further, the food or health products are candy, beverage, biscuit, bread, jelly or dietary supplements.
The present invention provides the preparation methods of the composition, include the following steps：The active constituent of each weight proportion is taken,
Be added in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
The present invention provides purposes of the composition in preparing the food, health products or drug of alleviating visual fatigue.
Further, the food, health products or drug have eyes local symptom and/or spirit caused by alleviating visual fatigue
The effect of nervous symptoms.
Further, the eyes local symptom be eye is ached, eye is swollen, photophobia, blurred vision, eye are dry and astringent, foreign body sensation or
It sheds tears.
Further, the Spirit nerve symptoms of disease is decreased attention, failure of memory, anxiety or insomnia.
The present invention provides composition for relieving asthenopia.Crowd's result on trial show the present composition not only for
Visual fatigue eyes local symptom, can more be obviously improved Spirit nerve symptoms of disease caused by different degrees of visual fatigue, not such as attention
Concentration, decrease of memory etc. alleviate visual fatigue significant effect, have a vast market foreground.
Specific implementation mode
The raw material that is used in the specific embodiment of the invention, equipment are known product, pass through and buy commercial product and obtain.
The present invention provides composition for relieving asthenopia, active constituent includes theanine, γ-aminobutyric acid and cyanine
Element.
Theanine (L-Theanine) i.e. N-ethyl-L-glutamine.Theanine is that one kind is mainly deposited in Theaceae plant
Unique amino acid.Theanine can inhibit the toxicity of glutamic acid, protect neuron；It is generated with α waves in E.E.G are promoted
Function alleviate depression and anxiety so as to cause light, pleasant feeling；Promote attention to concentrate, promotes reaction speed
And accuracy.Theanine existing for nature is L-type, is highly soluble in water.Theanine can be absorbed by intestinal wall, and human body takes in tea
Can be by blood-brain barrier after propylhomoserin 30min, 5h back brain theanine contents reach peak value, in being influenced by number of mechanisms
Pivot system function.Metabolism generates ethamine and glutamine in spleen.
γ-aminobutyric acid is most important inhibitory neurotransmitter in mammalian central nervous system, in vivo
A variety of nervous physiology activities are participated in, is had and is adjusted blood pressure, improve brain function, is anticonvulsion, promoting ataraxy, trophic nerve cell
Etc. physiological functions.In human brain, although γ-aminobutyric acid can be transformed by the glutamic acid of brain under the action of decarboxylase,
But the growth at age and stress increasing keep the accumulation of γ-aminobutyric acid extremely difficult.
The present invention can not only be effectively improved tired by regarding by the way that theanine, γ-aminobutyric acid and anthocyanidin to be applied in combination
What labor was brought seriously affects the general malaise symptom of work and life, including can mitigate or alleviate attention and decrease of memory
Problem, trier is generally reflected to be alleviated obviously using rear anxiety, and the sleeping problems caused by asthenopia are also relieved, and
And crowd's proof test shows that anthocyanidin is relatively applied alone more in the effect of present composition improvement visual fatigue eyes local symptom
Obviously, for example, eye is ached, eye is swollen, photophobia, blurred vision, eye are dry and astringent, foreign body sensation, the symptoms such as shed tears can access certain journey
The improvement of degree, it is very notable to the therapeutic effect of visual fatigue.
The preparation of 1 present composition of embodiment
Raw material weight proportioning of soup processed：200~400 parts of theanine, 100~300 parts of γ-aminobutyric acid, 100~200 parts of anthocyanidin,
100~400 parts of DHA, 5~15 parts of lutein ester, 1~5 part of (3R, 3'R)-dihydroxy-beta carotene.
Preparation method：
1, by weight ratio by theanine, gamma aminobutyric acid, anthocyanidin, DHA, (3R, 3'R)-dihydroxy-beta carotene,
Lutein ester is added syrup and stirs evenly after mixing.
2, hard, toffee, sandwich, crisp matter, burnt odor (too prince wife), inflation, gel, glue can be made in injection molding on demand after being cooled and shaped
The confectionery formats such as base, tabletting, liquid, diaphragm, fancy and chocolate and chocolate, substitute of cocoa fat chocolate and Dai Ke
It can the pan works such as fat chocolate, jelly (fruit juice type, fruit pulp type, fruit-flavor type, milk type etc.).
The preparation of 2 present composition of embodiment
Raw material weight proportioning of soup processed：200~400 parts of theanine, 100~300 parts of γ-aminobutyric acid, 100~200 parts of anthocyanidin,
100~400 parts of DHA, (3R, 3'R)-dihydroxy -1-10 parts of beta carotene, 1~25 part of lutein ester.
Preparation method：Select theanine, gamma aminobutyric acid, anthocyanidin, (3R, 3'R)-dihydroxy-beta carotene, leaf yellow
The raw material of plain ester mixes, be added required processing water and 30-45 liquid milks be sufficiently stirred, dissolved, homogeneous, homogenization pressure is
25Mpa, then ultra-high temperature sterilization is carried out, aseptic packaging, through being put in storage after the assay was approved.
The preparation of 3 present composition of embodiment
Raw material weight proportioning of soup processed：200~600 parts of theanine, 100~400 parts of γ-aminobutyric acid, 50~200 parts of anthocyanidin,
100~600 parts of DHA, (3R, 3'R)-dihydroxy -0.2-10 parts of beta carotene, 0.6~25 part of lutein ester.
Preparation method：Select theanine, gamma aminobutyric acid, anthocyanidin, DHA, (3R, 3'R)-dihydroxy-beta carotene,
Lutein ester stirs evenly, and ozone sterilization is filling, can directly take after mixing it with water or is added in other food as functional auxiliary material.
Beneficial effects of the present invention are proved below by way of test example.
1 present composition of test example alleviates visual fatigue and its related indication observation on probation
9 test groups are set, presses use measurement theanine, γ-aminobutyric acid, anthocyanidin (blueberry source) shown in table 2 respectively,
It the big opaque capsule such as is loaded into, tries to take for asthenope, continuously take 60 days (table 2, which corresponds to, daily to be measured), observation
Trial effect.
According to《Visual fatigue diagnosis and treatment Consensus of experts》(2014) are diagnosed as visual fatigue patient 225, and symptom includes vision barrier
Hinder：Near work or reading be not lasting, temporary blurred vision or ghost image occurs；Ophthalmic uncomfortable：Eye is swollen, ophthalmodynia, eye are burnt
Feel, shed tears, eye is itched, eye foreign body sense and eye socket pain.Constitutional symptom：Fatiguability has a headache, is dizzy, failure of memory, under memory
Drop, anxiety, irritated and other neurosiss symptoms.Age 18-65 Sui, random point 9 groups.Medicine, which is eaten, according to state supervises guarantorization
[2012] No. 107《Alleviate visual fatigue function evaluation methods》Visual fatigue measuring scale is worked out, is shown in Table 1.Constitutional symptom carries out individual event
Scoring：Decreased attention evaluates (0 point：It can adhere to being absorbed in work or learn 30 minutes；1 point：Occasionally there is decreased attention；2 points：When
There is decreased attention；3 points：Often there is decreased attention)；Decrease of memory evaluates (0 point：Yesterday, thing can all be recalled；1 point：
Occasionally there is decrease of memory；2 points：When have decrease of memory；3 points：Often there is decrease of memory)；Note：" occasionally having " refers to 1-2 times/2
It；" when have " refers to 1-3 times/day；" frequent " refers to>3 times/day.Calculating take before, take 60 days integral reduced rate：(treatment
Total mark after preceding total mark-treatment) preceding total mark × 100% of/treatment, post treatment integral reduced rate >=30% is effective.Symptom
Integral improves efficient statistical result and is shown in Table 2.
1 visual fatigue measuring scale of table (sxemiquantitative integration method)
Note：" random thoughts " refer to 1-2 times/2 days；" when have " refers to 1-3 times/day；" frequent " refers to>3 times/day
2 symptom integral of table improves efficient statistical result
Test group 1 is only added to anthocyanidin, and result on trial shows that it has significant alleviation visual fatigue eyes local symptom
Effect, improvement rate reaches 32% after taking 60 days, but it is slower to work, take 1 day it is efficient be only 8%.
Test group 2~9 is added to γ-aminobutyric acid and theanine on the basis of anthocyanidin, as a result significantly accelerated pair
The remission effect of eyes local symptom, it is effective more obvious after taking 1 day, and eyes local symptom is delayed after taking for a long time
Solve effect more preferably compared with test group 1.3 effect of test group decreases, it may be possible to because the additive amount of anthocyanidin is less, not up to rise
Effect amount.In addition, the test group of γ-aminobutyric acid and theanine, which is added, can also be obviously improved the whole bodies disease such as attention and memory
Shape.
From test group 2~9 as can be seen that the ratio range that theanine, γ-aminobutyric acid and anthocyanidin are limited in the present invention
Interior (i.e. 20~1000 parts of theanine, 10~1000 parts of γ-aminobutyric acid, 10-1000 parts of anthocyanidin) is applied in combination, and can send out
The apparent effect for alleviating visual fatigue is waved, has apparent treatment to the eyes local symptom and constitutional symptom that influence visual fatigue crowd
Effect.Wherein, it is preferably in a proportion of：200~400 parts of theanine, 100~300 parts of γ-aminobutyric acid, 100~200 parts of anthocyanidin.
It observes in this experiment, after taking product 1 day, apparent anxiety and irritated reduction, feeling of fatigue occurs in user
Mitigate, the relevant constitutional symptom of visual fatigue is such as had a headache, eyes local symptom such as blurred vision or ghost image is substantially reduced.Long-term effect
Gradually show after 15~30 days, 60 days more stable, visual fatigue relevant eyes part (eye is swollen, ophthalmodynia, eye are dry, burn feeling,
Foreign body sensation, blurred vision or ghost image) etc. have a better role, attention and memory all improve significantly.When
After theanine, γ-aminobutyric acid and anthocyanidin compounding, not only improved visual fatigue constitutional symptom but also improved eyes local symptom, it is anti-to regard
Fatigue effect has promotion, especially best proportion range effect more apparent in respective field.
Claims (13)
1. composition for relieving asthenopia, it is characterized in that：Active constituent includes theanine, γ-aminobutyric acid and anthocyanidin.
2. composition as described in claim 1, it is characterized in that：The weight proportion of the active constituent is：Theanine 20~
1000 parts, 10~1000 parts of γ-aminobutyric acid, 10~1000 parts of anthocyanidin.
3. composition as claimed in claim 2, it is characterized in that：The weight proportion of the active constituent is：Theanine 100~
400 parts, 70~500 parts of γ-aminobutyric acid, 20~500 parts of anthocyanidin；Preferably, the weight proportion of the active constituent is：Tea
200~400 parts of propylhomoserin, 100~300 parts of γ-aminobutyric acid, 100~200 parts of anthocyanidin；It is further preferred that it is described activity at
Point weight proportion be：Theanine：γ-aminobutyric acid：Anthocyanidin=(1~2)：1：1.
4. the composition as described in claims 1 to 3 any one, it is characterized in that：The anthocyanidin from blueberry, cowberry,
European cranberry, purple sweetpotato, blood orange, red cabbage, eggplant, cherry, the red certain kind of berries, strawberry, mulberries, hawthorn, morning glory, matrimony vine, connects grape
Bone is wooden, one or more kinds of in red, blackcurrant, purple carrot and red cabbage.
5. the composition as described in Claims 1 to 4 any one, it is characterized in that：Active constituent further includes DHA, lutein, leaf
One or more kinds of mixture in flavine ester, (3R, 3'R)-dihydroxy-beta carotene.
6. composition as claimed in any one of claims 1 to 5, wherein, it is characterized in that：It is the active constituent of each weight proportion, is added
Food, health products or the drug that acceptable auxiliary material or complementary ingredient are prepared.
7. composition as claimed in claim 6, it is characterized in that：The food, health products or drug are oral form.
8. composition as claimed in claim 7, it is characterized in that：The food or health products be candy, beverage, biscuit, bread,
Jelly or dietary supplements.
9. the preparation method of composition described in claim 1~8 any one, it is characterized in that：Include the following steps：Take each weight
The active constituent of proportioning, be added in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
10. composition described in claim 1~8 any one is in preparing the food, health products or drug of alleviating visual fatigue
Purposes.
11. purposes as claimed in claim 10, it is characterized in that：The food, health products or drug, which have, alleviates visual fatigue institute
The effect of causing eyes local symptom and/or Spirit nerve symptoms of disease.
12. purposes as claimed in claim 11, it is characterized in that：The eyes local symptom is that eye is ached, eye is swollen, photophobia, is regarded
Object is fuzzy, eye is dry and astringent, foreign body sensation or sheds tears.
13. purposes as claimed in claim 11, it is characterized in that：The Spirit nerve symptoms of disease is decreased attention, memory subtracts
It moves back, anxiety or insomnia.
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| CN109619566A (en) * | 2019-01-22 | 2019-04-16 | 广州硕维食品技术有限公司 | A kind of nutraceutical for alleviating asthenopia |
| CN116210896A (en) * | 2022-12-12 | 2023-06-06 | 福州三合元生物科技有限公司 | Preparation method of health product with gamma aminobutyric acid |
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Application publication date: 20180727 |