CN108042652A - Composition for relieving asthenopia containing matrimony vine, chrysanthemum and γ-aminobutyric acid - Google Patents
Composition for relieving asthenopia containing matrimony vine, chrysanthemum and γ-aminobutyric acid Download PDFInfo
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- CN108042652A CN108042652A CN201810142338.9A CN201810142338A CN108042652A CN 108042652 A CN108042652 A CN 108042652A CN 201810142338 A CN201810142338 A CN 201810142338A CN 108042652 A CN108042652 A CN 108042652A
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- Prior art keywords
- matrimony vine
- composition
- chrysanthemum
- parts
- active ingredient
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- 208000003464 asthenopia Diseases 0.000 title claims abstract description 53
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title claims abstract description 50
- 244000241838 Lycium barbarum Species 0.000 title claims abstract description 45
- 235000015459 Lycium barbarum Nutrition 0.000 title claims abstract description 45
- 235000007516 Chrysanthemum Nutrition 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 229960003692 gamma aminobutyric acid Drugs 0.000 title claims abstract description 22
- XLOPRKKSAJMMEW-UHFFFAOYSA-N chrysanthemic acid Chemical compound CC(C)=CC1C(C(O)=O)C1(C)C XLOPRKKSAJMMEW-UHFFFAOYSA-N 0.000 title claims abstract description 9
- 244000189548 Chrysanthemum x morifolium Species 0.000 title 1
- 241000723353 Chrysanthemum Species 0.000 claims abstract description 37
- 208000024891 symptom Diseases 0.000 claims abstract description 37
- 239000004480 active ingredient Substances 0.000 claims abstract description 29
- 230000036541 health Effects 0.000 claims abstract description 15
- 230000000694 effects Effects 0.000 claims abstract description 13
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 10
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- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 10
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims description 7
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims description 7
- 244000246386 Mentha pulegium Species 0.000 claims description 7
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 7
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 7
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- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
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- 238000000034 method Methods 0.000 description 3
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- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
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- -1 DHA200 parts Chemical compound 0.000 description 1
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- 229930014669 anthocyanidin Natural products 0.000 description 1
- 150000001452 anthocyanidin derivatives Chemical class 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
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- 230000001886 ciliary effect Effects 0.000 description 1
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- 238000005286 illumination Methods 0.000 description 1
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- 238000000528 statistical test Methods 0.000 description 1
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Classifications
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- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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Abstract
The present invention relates to the composition for relieving asthenopia containing matrimony vine, chrysanthemum and gamma aminobutyric acid, belong to medical and health field.The present invention provides composition for relieving asthenopia, active ingredient includes matrimony vine, chrysanthemum and gamma aminobutyric acid.Crowd's result on trial shows, the present composition is not only for visual fatigue eyes local symptom, Spirit nerve symptoms of disease caused by more being obviously improved different degrees of visual fatigue, such as absent minded, decrease of memory, alleviate visual fatigue significant effect, have a vast market prospect.
Description
Technical field
The present invention relates to the composition for relieving asthenopia containing matrimony vine, chrysanthemum and γ-aminobutyric acid, belong to medical and health neck
Domain.
Background technology
Visual fatigue is also known as asthenopia, is eye or whole body apparatus factors and spirit based on the subjective symptoms of patient's eye
The syndrome that (psychology) factor is interweaved, and the eye disease of dependent, thus commonly referred to as asthenopia syndrome (referring to:1、
Li Fengming China ophthalmology [M] Beijing:People's Health Publisher, 2006,7~8;2nd, the visual fatigues cause of disease such as canal letter grain husk and its
Progress [J] the China TCM Ophthalmology magazine for the treatment of, 2003,14 (1):59~61).Slight visual fatigue can go out after with eye
Losing face, portion is sour, the eye symptoms such as swollen, recovers quickly after rest;Moderate visual fatigue has apparent eye symptom, influence study and
Work;Severe visual fatigue is except have apparent eye symptom and be regarded as industry cannot be persistently outer, also whole bodies such as failure of memory, insomnia
Malaise symptoms disturb the vision and quality of life of patient, seriously affect study, work and life (referring to:Horse gets over anthocyanidin drink
Material alleviates human trial observation Chinese foods journal [J] .2015 of visual fatigue effect, 8 (15):8).
Substantial amounts of clinical practice proves, one of ametropia the main reason for being visual fatigue, as long sight, astigmatism, myopia are suffered from
Person when not giving correction of refractive errors, sees far or employing larger adjusting when seeing near makes ciliary muscle constant tension cause patient's
Accommodative asthenopia.In addition, the factors such as long-time near work, work or reading environment illumination deficiency can result in human eye
Adjust nervous, generation visual fatigue.The state of mind and systemic conditions of patient is also closely related with the generation of visual fatigue, stress
Greatly, the patient having bad physiques is also easy to produce visual fatigue.
As mobile phone, tablet computer are extensively into people’s lives, crowd is all with constantly extending between at the moment, closely uses
Eye intensity increase, the incidence of each age stratum visual fatigue rapidly increase.Visual fatigue can be improved, and alleviate and brought by visual fatigue
Attention, decrease of memory the problems such as product be increasingly subject to consumers.
At present, on the market improve visual fatigue product generally only for blue light damage in itself, eyes local symptom is changed
Kind effect unobvious, and other symptoms caused by different degrees of visual fatigue can not be solved, such as absent minded, memory
Decline etc..Therefore it provides it is a kind of to visual fatigue eyes local symptom and the apparent product of Spirit nerve symptoms of disease remission effect, become
One urgent problem to be solved.
The content of the invention
It is an object of the invention to provide composition for relieving asthenopia.
The present invention provides composition for relieving asthenopia, active ingredient includes matrimony vine, chrysanthemum and γ-aminobutyric acid.
Further, the weight proportion of the active ingredient is:500~12000 parts of matrimony vine, 500~6000 parts of chrysanthemum,
10~1000 parts of γ-aminobutyric acid.
Further, the weight proportion of the active ingredient is:6000~12000 parts of matrimony vine, 3000~6000 parts of chrysanthemum,
70~500 parts of γ-aminobutyric acid.
Preferably, the weight proportion of the active ingredient is:6000~12000 parts of matrimony vine, 3000~6000 parts of chrysanthemum,
100~300 parts of γ-aminobutyric acid.
Further, the matrimony vine is lycium barbarum, Chinese matrimony vine, black fruit fructus lycii, Lycium barbarum, section calyx matrimony vine, column casing
It is one or more kinds of in matrimony vine, Yunnan matrimony vine, yellow fruit matrimony vine, red branch matrimony vine, northern Lycium chinense.
Further, the chrysanthemum is one or more kinds of in Hang Ju, Bo chrysanthemum, tribute chrysanthemum, chu chrysanthemum.
Further, active ingredient further include phosphatidylserine, DHA, raspberry, peppermint, lutein, lutein ester,
One or more kinds of mixture in (3R, 3'R)-dihydroxy-beta carotene.
Further, active ingredient further includes 10-1000 parts of phosphatidylserine.
Further, active ingredient further includes DHA10-1000 parts.
Further, active ingredient further includes 0.6~25 part of lutein and/or lutein ester.
Further, active ingredient further includes 0.2~10 part of (3R, 3'R)-dihydroxy-beta carotene.
Further, active ingredient further includes 500~1000 parts of raspberry.
Further, active ingredient further includes 1000~3000 parts of peppermint.
Further, the composition is the active ingredient of each weight proportion, adds in acceptable auxiliary material or auxiliary
Food, health products or the drug that property ingredient is prepared.
Further, the food, health products or drug are oral form.
Further, the food or health products are candy, beverage, biscuit, bread, jelly or dietary supplements.
The present invention provides the preparation methods of the composition, include the following steps:The active ingredient of each weight proportion is taken,
Add in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
The present invention provides purposes of the composition in the food for alleviating visual fatigue, health products or drug is prepared.
Further, the food, health products or drug have eyes local symptom and/or spirit caused by alleviation visual fatigue
The effect of nervous symptoms.
Further, the eyes local symptom for eye is ached, eye is swollen, photophobia, blurred vision, eye are dry and astringent, foreign body sensation or
It sheds tears.
Further, the Spirit nerve symptoms of disease is decreased attention, failure of memory, anxiety or insomnia.
The present invention provides composition for relieving asthenopia.Crowd's result on trial show the present composition not only for
Visual fatigue eyes local symptom, Spirit nerve symptoms of disease caused by more being obviously improved different degrees of visual fatigue, such as attention not
Concentration, decrease of memory etc. alleviate visual fatigue significant effect, have a vast market prospect.
Specific embodiment
The raw material that is used in the specific embodiment of the invention, equipment are known product, are obtained by buying commercial product.
The present invention provides composition for relieving asthenopia, active ingredient includes matrimony vine, chrysanthemum and γ-aminobutyric acid.
The present invention can not only be effectively improved by the way that matrimony vine, chrysanthemum and γ-aminobutyric acid are applied in combination by visual fatigue band
That comes seriously affects the general malaise symptom of work and life, is asked including that can mitigate or alleviate attention and decrease of memory
Topic, trier is generally reflected to be alleviated substantially using rear anxiety, and the sleeping problems triggered by asthenopia are also relieved, and
And crowd's proof test shows that the present composition improves the effect of visual fatigue eyes local symptom compared with matrimony vine and chrysanthemum more
Substantially, for example, eye is ached, eye is swollen, photophobia, blurred vision, eye are dry and astringent, foreign body sensation, the symptoms such as shed tears can access certain journey
The improvement of degree, it is very notable to the therapeutic effect of visual fatigue.
It is prepared by 1 candy of the present invention of embodiment
Raw materials by weight portion meter:6 parts of lutein ester;2 parts of (3R, 3'R)-dihydroxy-beta carotene;Matrimony vine 10000
Part;3000 parts of chrysanthemum;500 parts of raspberry;1000 parts of peppermint;300 parts of γ-aminobutyric acid, DHA200 parts, phosphatidyl serine
200 parts.
Preparation method:
1st, matrimony vine, chrysanthemum, raspberry, peppermint are added in 10 times of clear water by weight ratio and boils 15-30 minutes, mistake
Filter, the water that solid matter adds same amount repeats the above process 2 times, collect filtrate concentration three times, it is dry, crush after with
(3R, 3'R)-dihydroxy-beta carotene, γ-aminobutyric acid, DHA, phosphatidyl serine, lutein ester add in after mixing
Syrup stirs evenly.
2nd, gel soft candy, pressed candy, chocolate, hard candy, crisp matter sugar, rainbow can be made in injection molding on demand after being cooled and shaped
The types such as sugar, aerated candy, matrix sugar.
The preparation of 2 beverage of the present invention of embodiment
Raw materials by weight portion meter:12 parts of lutein ester;4 parts of (3R, 3'R)-dihydroxy-beta carotene;Matrimony vine 10000
Part;6000 parts of chrysanthemum;500 parts of raspberry;2000 parts of peppermint, 200 parts of γ-aminobutyric acid, 200 parts of phosphatidyl serine, DHA50
Part.
Preparation method:
1st, matrimony vine, chrysanthemum, raspberry, peppermint are added in 10 times of clear water by weight ratio and boils 15-30 minutes, mistake
Filter, the water that solid matter adds same amount repeat the above process 2 times, collect filtrate concentration, dry, crushing three times
2nd, by weight percentage by 1 crushed material and (3R, 3'R)-dihydroxy-beta carotene, γ-aminobutyric acid, DHA,
Phosphatidyl serine, lutein ester add in syrup and stir evenly after mixing.
3rd, various beverages are made on demand.
Beneficial effects of the present invention are proved below by way of test example.
1 present composition of test example alleviates visual fatigue and its related indication observation on probation
This experiment basis《Visual fatigue diagnosis and treatment Consensus of experts (2014)》And state's food medicine prison guarantorization [2012] 107《Alleviate
Visual fatigue function evaluation methods》Work out visual fatigue measuring scale.Collection examination 240 people of trencherman, 127 people of male, 113 people of women.Point
Carry out eye symptom and funduscopy not before and after test-meal, blood, routine urianlysis, Liver and kidney function inspection, symptom inquiry, with eye
Condition survey, SAS scorings, duration of photopic vision and eye test, examination of distant vision.Eyes local symptom:Eye is ached, eye is swollen, fear
Light, blurred vision, eye are dry and astringent, have wantonly 3 kinds of improvement in foreign body sensation, 7 kinds of symptoms of shedding tears, and other symptoms are to judge eyes without deteriorating
Local symptom improves, and general malaise (including decreased attention, failure of memory, insomnia) carries out statistics of single item.Calculate two groups of diseases
Shape, which improves number of cases and two groups of symptoms, improves effective percentage.Symptom improves efficient (%) computational methods improves number of cases/test-meal for symptom
Number of cases × 100.Two groups of symptoms are improved into efficient progress statistical test.
1 visual fatigue measuring scale of table
Subject is randomly divided into 8 groups, every group 30, it is matrimony vine 6000mg chrysanthemums 3000mg's that 1 group, which is given active ingredient,
Candy, 2 groups are given the candy that active ingredient is matrimony vine 6000mg chrysanthemum 3000mg γ-aminobutyric acids 500mg, and 3 groups are given activity
Ingredient is the candy of matrimony vine 500mg chrysanthemum 6000mg γ-aminobutyric acids 10mg, and 4 groups are given active ingredient as matrimony vine 12000mg chrysanthemums
The candy of flower 500mg γ-aminobutyric acids 1000mg, 5 groups are given active ingredient as matrimony vine 6000mg chrysanthemum 6000mg gamma-amino fourths
The candy of sour 70mg, 6 groups give active ingredient be matrimony vine 12000mg chrysanthemum 3000mg γ-aminobutyric acids 500mg candy, 7 groups
The candy that active ingredient is matrimony vine 6000mg chrysanthemum 6000mg γ-aminobutyric acids 100mg is given, 8 groups are given active ingredient as Chinese holly
The sugar of Qi 12000mg chrysanthemum 3000mg γ-aminobutyric acids 300mg.Each group candy is prepared according to 1 method of embodiment, using peaceful
Summer matrimony vine and Hang Ju.8 groups are continuously taken 60 days (being daily to measure above).Respectively at 1 day, 60 days statistics eyes parts
Symptom improve effective percentage and influence Working Life visual fatigue Spirit nerve symptoms of disease mainly include decreased attention, anxiety,
The variation of insomnia is taken front and rear comparing result and be see the table below:
Table 2 alleviates visual fatigue symptom effective percentage statistical form
Test group 1 is only with the addition of matrimony vine and chrysanthemum, and result on trial shows that it has and alleviates visual fatigue eyes local symptom
Effect, effective percentage reaches 30% after taking 60 days, but it is slower to work, without positive effect in the short time.
Test group 2~8 is with the addition of γ-aminobutyric acid on the basis of Qi chrysanthemum, as a result significantly accelerated to eyes part disease
The remission effect of shape, it is effective more obvious after taking 1 day, and the remission effect of eyes local symptom is relatively tried after long-term use
Test group 1 more preferably.3 effect of test group is declined, it may be possible to because γ-aminobutyric acid additive amount is less, not up to action amount.This
Outside, the constitutional symptoms such as attention and insomnia can also be obviously improved by adding in the test group of γ-aminobutyric acid.
Present invention combination can improve visual fatigue symptom comprehensively, and it is fast compared with other products on the market to work, and is easy to consumer
Adhere to using the purpose for being finally reached alleviation visual fatigue.
Claims (14)
1. composition for relieving asthenopia, it is characterized in that:Active ingredient includes matrimony vine, chrysanthemum and γ-aminobutyric acid.
2. composition as described in claim 1, it is characterized in that:The weight proportion of the active ingredient is:Matrimony vine 500~
12000 parts, 500~6000 parts of chrysanthemum, 10~1000 parts of γ-aminobutyric acid.
3. composition as claimed in claim 2, it is characterized in that:The weight proportion of the active ingredient is:Matrimony vine 6000~
12000 parts, 3000~6000 parts of chrysanthemum, 70~500 parts of γ-aminobutyric acid;Preferably, the weight proportion of the active ingredient
For:6000~12000 parts of matrimony vine, 3000~6000 parts of chrysanthemum, 100~300 parts of γ-aminobutyric acid.
4. the composition as described in claims 1 to 3 any one, it is characterized in that:The matrimony vine is lycium barbarum, Chinese Chinese holly
In Qi, black fruit fructus lycii, Lycium barbarum, section calyx matrimony vine, column casing matrimony vine, Yunnan matrimony vine, yellow fruit matrimony vine, red branch matrimony vine, northern Lycium chinense
It is one or more kinds of.
5. the composition as described in claims 1 to 3 any one, it is characterized in that:The chrysanthemum is Hang Ju, Bo chrysanthemum, tribute chrysanthemum, Chu
It is one or more kinds of in chrysanthemum.
6. composition as claimed in any one of claims 1 to 5, wherein, it is characterized in that:Active ingredient further include phosphatidylserine,
It is one or more kinds of in DHA, raspberry, peppermint, lutein, lutein ester, (3R, 3'R)-dihydroxy-beta carotene to mix
Close object.
7. the composition as described in claim 1~6 any one, it is characterized in that:It is the active ingredient of each weight proportion, adds in
Food, health products or the drug that acceptable auxiliary material or complementary ingredient are prepared.
8. composition as claimed in claim 7, it is characterized in that:The food, health products or drug are oral form.
9. composition as claimed in claim 8, it is characterized in that:The food or health products are candy, beverage, biscuit, bread,
Jelly or dietary supplements.
10. the preparation method of composition described in claim 1~9 any one, it is characterized in that:Include the following steps:It takes each heavy
Measure the active ingredient of proportioning, add in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
11. composition described in claim 1~9 any one is in the food for alleviating visual fatigue, health products or drug is prepared
Purposes.
12. purposes as claimed in claim 11, it is characterized in that:The food, health products or drug, which have, alleviates visual fatigue institute
The effect of causing eyes local symptom and/or Spirit nerve symptoms of disease.
13. purposes as claimed in claim 12, it is characterized in that:The eyes local symptom is eye is ached, eye is swollen, photophobia, is regarded
Object obscures, eye is dry and astringent, foreign body sensation or sheds tears.
14. purposes as claimed in claim 12, it is characterized in that:The Spirit nerve symptoms of disease is decreased attention, memory subtracts
It moves back, anxiety or insomnia.
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