CN108244640A - Composition for relieving asthenopia containing flake and γ-aminobutyric acid - Google Patents

Composition for relieving asthenopia containing flake and γ-aminobutyric acid Download PDF

Info

Publication number
CN108244640A
CN108244640A CN201810141540.XA CN201810141540A CN108244640A CN 108244640 A CN108244640 A CN 108244640A CN 201810141540 A CN201810141540 A CN 201810141540A CN 108244640 A CN108244640 A CN 108244640A
Authority
CN
China
Prior art keywords
fish
tissue
composition
parts
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810141540.XA
Other languages
Chinese (zh)
Inventor
魏巍
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chengdu Map Biotechnology Co Ltd
Original Assignee
Chengdu Map Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Map Biotechnology Co Ltd filed Critical Chengdu Map Biotechnology Co Ltd
Priority to CN201810141540.XA priority Critical patent/CN108244640A/en
Publication of CN108244640A publication Critical patent/CN108244640A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to the composition for relieving asthenopia containing flake and gamma aminobutyric acid, belong to medical and health field.The present invention provides composition for relieving asthenopia, active constituent includes fish eyeball tissue or its extract, fish eye socket tissue or its extract and gamma aminobutyric acid.Crowd's result on trial shows, the present composition is not only for visual fatigue eyes local symptom, Spirit nerve symptoms of disease caused by more being obviously improved different degrees of visual fatigue, such as absent minded, decrease of memory, alleviate visual fatigue significant effect, have a vast market prospect.

Description

Composition for relieving asthenopia containing flake and γ-aminobutyric acid
Technical field
The present invention relates to the composition for relieving asthenopia containing flake and γ-aminobutyric acid, belong to medical and health field.
Background technology
Visual fatigue is also known as asthenopia, is eye or whole body apparatus factors and spirit based on the subjective symptoms of patient's eye The syndrome that (psychology) factor is interweaved, and the eye disease of dependent, thus commonly referred to as asthenopia syndrome (referring to：1、 Li Fengming China ophthalmology [M] Beijing：People's Health Publisher, 2006,7~8；2nd, the visual fatigues cause of disease such as canal letter grain husk and its Progress [J] the China TCM Ophthalmology magazine for the treatment of, 2003,14 (1)：59~61).Slight visual fatigue can go out after with eye Losing face, portion is sour, the eye symptoms such as swollen, restores quickly after rest；Moderate visual fatigue has apparent eye symptom, influence study and Work；Severe visual fatigue except have apparent eye symptom and be regarded as industry cannot persistently in addition to, also whole bodies such as failure of memory, insomnia Malaise symptoms interfere the vision and quality of life of patient, seriously affect study, work and life (referring to：Horse gets over anthocyanidin drink Material alleviates human trial observation Chinese foods journal [J] .2015 of visual fatigue effect, 8 (15)：8).
A large amount of clinical practice proves, one of ametropia the main reason for being visual fatigue, as long sight, astigmatism, myopia are suffered from Person when not giving correction of refractive errors, sees far or employing larger adjusting when seeing near makes ciliary muscle constant tension cause patient's Accommodative asthenopia.In addition, the factors such as long-time near work, work or reading environment illumination deficiency can result in human eye Adjust nervous, generation visual fatigue.The state of mind and systemic conditions of patient is also closely related with the generation of visual fatigue, stress Greatly, the patient having bad physiques is also easy to produce visual fatigue.
As mobile phone, tablet computer enter people’s lives extensively, crowd's entirety is closely used with constantly extending between at the moment Eye intensity increase, the incidence of each age stratum visual fatigue rapidly increase.Visual fatigue can be improved, and alleviate and brought by visual fatigue Attention, decrease of memory the problems such as product increasingly by consumers.
At present, on the market improve visual fatigue product generally only for blue light damage in itself, eyes local symptom is changed Kind effect unobvious, and other symptoms caused by different degrees of visual fatigue can not be solved, such as absent minded, memory Decline etc..Therefore it provides it is a kind of to visual fatigue eyes local symptom and the apparent product of Spirit nerve symptoms of disease remission effect, become One urgent problem to be solved.
Invention content
The purpose of the present invention is to provide composition for relieving asthenopia.
The present invention provides composition for relieving asthenopia, active constituent includes fish eyeball tissue or its extract, flake Nest tissue or its extract and γ-aminobutyric acid.
Further, the weight proportion of the active constituent is：10~1000 parts of fish eyeball tissue, fish eye socket tissue 10~ 1000 parts, 10~1000 parts of γ-aminobutyric acid.
Preferably, the weight proportion of the active constituent is：100~800 parts of fish eyeball tissue, fish eye socket tissue 100~ 800 parts, 70~500 parts of γ-aminobutyric acid.
It is further preferred that the weight proportion of the active constituent is：300~600 parts of fish eyeball tissue, fish eye socket tissue 300~600 parts, 100~300 parts of γ-aminobutyric acid.
Most preferably, the weight proportion of the active constituent is：Fish eyeball tissue：Fish eye socket tissue：γ-aminobutyric acid= 1：1：(0.5~1).
The weight proportion is in terms of fish eyeball tissue, fish eye socket tissue fresh goods weight.
Further, the fish eyeball tissue or fish eye socket tissue are selected from yaito tuna, tuna, stripped tuna, scad, Rofe Fish, ray fish, gadus, mackerel, hard squama perch, smelt, salmon, sand lance, red coat, anglerfish, great white shark, gurnet, it is bright too Fish, east perch, carp, crucian, black carp, marlin, red porgy, grey mullet, Spanish mackerel, catfish, silverfish, saury, sunfish, black porgy, Hairtail, zingel, loach, snakeheaded fish, is aunt fish, east Peristedion, swordfish, fugu obscurus, yellowfin tuna, ash at mandarin fish Mackerel shark, yellow croaker, filefish, sole, mouse fish, hilsa herring, Hei Jun fishes, sardine, spot fin chromide, atka mackerel, tilefiss, eel The eyeball tissue or orbital structures of one or more kinds of fish in fish, butterfish, spotted maigre.
Further, the extract is water extract or alcohol extract.
Further, active constituent further includes phosphatidylserine, anthocyanidin, astaxanthin, procyanidine, lutein, leaf One or more kinds of mixture in flavine ester, (3R, 3'R)-dihydroxy-beta carotene.
Further, active constituent further includes 10~1000 parts of phosphatidylserine；It is preferred that 100~600 parts.
Further, active constituent further includes 10~1000 parts of anthocyanidin；It is preferred that 20-500 parts.
Further, active constituent further includes 1~250 part of astaxanthin.
Further, active constituent further includes 1~800 part of procyanidine；It is preferred that 1-200 parts.
Further, active constituent further includes 0.6~25 part of lutein and/or lutein ester；It is preferred that 1~25 part.
Further, active constituent further includes 0.2~10 part of (3R, 3'R)-dihydroxy-beta carotene；It is preferred that 1~10 Part.
The anthocyanidin from blueberry, cowberry, european cranberry, grape, purple sweetpotato, blood orange, red cabbage, eggplant, cherry, It is one or two kinds of in the red certain kind of berries, strawberry, mulberries, hawthorn, morning glory, matrimony vine, elder, red, blackcurrant, purple carrot and red cabbage More than.
The procyanidine from grape pip, grape, hawthorn, peanut, ginkgo, blueberry, black soya bean, rape, oil tea, rice, Sorghum, cocoa, broad bean, hyacinth bean, lichee, sea-buckthorn, apple, blackberry, blueberry, wild strawberry, longan, cowberry, arrow-leaved oleaster, european cranberry, persimmon, mountain Bamboo, pomegranate, cypress, pine tree, white popinac, silver birch, eucalyptus, uncaria Chinese white poplar, Chinese cassia tree, thick grass, tealeaves, grapevine, mountain radix scrophulariae, Hypericum perforatum bay, eucalyptus, rose, leads a cow, is purple plague purpura water spinach, red clover, water lily, crotons, garden burnet, purple sweetpotato, elegant jessamine, big It is one or more kinds of in yellow, different leaf fogfruit.
Further, the composition is the active constituent of each weight proportion, adds in acceptable auxiliary material or auxiliary Food, health products or the drug that property ingredient is prepared.
Further, the food, health products or drug are oral form.
Further, the food or health products are candy, beverage, biscuit, bread, jelly or dietary supplements.
The present invention provides the preparation methods of the composition, include the following steps：The active constituent of each weight proportion is taken, Add in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
The present invention provides purposes of the composition in the food for alleviating visual fatigue, health products or drug is prepared.
Further, the food, health products or drug have eyes local symptom and/or spirit caused by alleviation visual fatigue The effect of nervous symptoms.
Further, the eyes local symptom for eye is ached, eye is swollen, photophobia, blurred vision, eye are dry and astringent, foreign body sensation or It sheds tears.
Further, the Spirit nerve symptoms of disease is decreased attention, failure of memory, anxiety or insomnia.
The present invention provides composition for relieving asthenopia.Crowd's result on trial show the present composition not only for Visual fatigue eyes local symptom, Spirit nerve symptoms of disease caused by more being obviously improved different degrees of visual fatigue, such as attention not Concentration, decrease of memory etc. alleviate visual fatigue significant effect, have a vast market prospect.
Specific embodiment
The raw material that is used in the specific embodiment of the invention, equipment are known product, are obtained by buying commercial product.
The present invention provides composition for relieving asthenopia, active constituent includes fish eyeball tissue or its extract, fish Orbital structures or its extract and γ-aminobutyric acid.
The construction of flake eyeball is relatively simple, most fish without eyelid and eyeball is completely exposed, flake eyeball appearance be in ellipsoid Shape, in the eye socket surrounded by supra-orbital, several socket of the eye ossiculums and soft cranium.The flake of general ocean fish is divided into from outside to inside under light microscopic Corneo-scleral layer, iris-choroid layer, crystalline lens and layer of retina.It is transparent cornea before eyeball, remaining is brownish black Sclera.It is made of on the inside of eyeball muscle, optic nerve, blood vessel and cartilage (optic stalk).The size of flake eyeball and it daily contacted Light be relative.The upper strata of water or the fish in middle level are moved in, they have normal eyes, such as carp, crucian, yellow croaker Fish.And the fish of 300~1500 meters of depths are lived in, because light here is extremely weak, general eyes are all bigger, such as big eye porgy Fish.Flake eyeball rich in vitamin, active peptides, amino acid, carbohydrate, various trace elements (calcium, phosphorus, iron, zinc etc.) and including A variety of unrighted acids including omega-fatty acid, these substances have comprehensive beneficial effect to the metabolism of eyes.
Fish eye socket tissue is the musculature and adipose tissue being located at around flake eyeball, wherein, fish eye socket adipose tissue (eye Nest fat is one kind of the structural fatty in eyeball behind, is existed for protection optic nerve, plays protection eyeball from Gao Shui Weigh harmful buffer effect wounded, while again as DHA supply sources necessary to brain, retina) fat content height, especially ocean fish Containing a large amount of polyunsaturated fatty acid in fish eye socket adipose tissue, ω -3 highly unsaturated fatty acids series therein is (mainly It is DHA, EPA) there is special physiological function.DHA is nervous system growth and a kind of essential element maintained, is brain and regards The important composition ingredient of nethike embrane, content is up to 20% in human brain cortex, and proportion is maximum in eyes regard film, accounts for about 50%.DHA is known as " docosapentaenoic acid " and " clever motive power ", but human body itself cannot synthesize DHA, can only be taken the photograph from food It takes.
At present, the report that rarely seen fish eyeball tissue, fish eye socket tissue or its extract are used alone, purposes are mainly anti-blood Bolt increases and regards improving eyesight etc., but there is not yet fish eyeball tissue or fish eye socket tissue alleviate the correlative study of visual fatigue effect, more have no by The report that the two is applied in combination.
For the present invention by crowd's probationary certificate, fish eyeball tissue, fish eye socket tissue are respectively provided with significant alleviation visual fatigue Effect aches to eye caused by visual fatigue, eye is swollen, photophobia, blurred vision, foreign body sensation, the symptoms such as shed tears can play centainly The mitigation of degree, moreover, by after fish eyeball tissue and fish eye socket stitch combinations use, the beneficial eye ingredient that the two is rich in is in work( Complementation has been obtained in effect, synergistic effect can have been played so that the effect for alleviating visual fatigue is further promoted.
In addition, active constituent γ-aminobutyric acid is additionally added in the present composition.
γ-aminobutyric acid is most important inhibitory neurotransmitter in mammalian central nervous system, in vivo A variety of nervous physiology activities are participated in, is had and is adjusted blood pressure, improve brain function, is anticonvulsion, promoting ataraxy, trophic nerve cell Etc. physiological functions.In human brain, although γ-aminobutyric acid can be transformed by the glutamic acid of brain under the action of decarboxylase, But the growth at age and stress increasing make the accumulation of γ-aminobutyric acid extremely difficult.
The present invention is added to by regarding γ-aminobutyric acid as active constituent in the product containing flake ball and fish eye socket, Can significantly accelerated flake to the remission effect of eyes local symptom, can be effective after taking 1 day, and to eye after taking for a long time Flake is relatively applied alone more preferably in the remission effect of eyeball local symptom.In addition, add in γ-aminobutyric acid after can also be obviously improved attention and The visual fatigues constitutional symptom such as memory, it is generally anti-including that can mitigate or alleviate attention and decrease of memory problem, trier It reflects and is alleviated significantly using rear anxiety, the sleeping problems caused by asthenopia are also relieved.
The present invention is improving efficacy of relieving visual fatigue simultaneously, enables a consumer to most experience effect soon, significantly improves consumption Person uses wish, so as to which the alleviation for making visual fatigue becomes easily simple.
The flakes ball such as 1 yaito tuna of embodiment, tuna, stripped tuna, scad, Tilapia mossambica extract (using DHA as index components) Manufacture
Feedstock processing：Fresh ocean fish flake (eyeball tissue) is taken to be eluted with water, after draining, in the citric acid of 0.05-0.1% 10-30min is impregnated in solution, moisture content is dried in 40-70 DEG C less than 4%, then be crushed to the ocean fish powder of 100-200 mesh；
Enzymolysis：Buffer solution is added with 6mol/L hydrochloric acid tune pH value to be 4-6 ocean fish powder after processing, add in mass fraction 0.1-1.0%, enzyme activity 3.0 × 104The papain of u/g and mass fraction 0.5-1.5%, enzyme activity 1.0 × 104The fiber of u/g Plain enzyme, in 40-60 DEG C of stirring enzymolysis 1-2h, later with 0.5mo1/L sodium hydroxide tune pH to neutrality；
Vacuum extraction：Obtained ocean fish enzymolysis liquid is placed in vacuum extraction equipment, controls vacuum degree 85-90KPa, temperature 40-60 DEG C is extracted 1-2 hours, while enzyme deactivation, obtains extracting solution；
Separation：Extracting solution in 6000rpm is centrifuged 20 minutes, collects supernatant；
Concentration：Obtained liquid is placed in vacuum concentration equipment, controls vacuum degree 85-90KPa, 40-60 DEG C of temperature is dense The l/5-1/3 of original volume is reduced to, obtains DHA concentrates.
The fish eye sockets extracts such as 2 yaito tuna of embodiment, tuna, stripped tuna, scad, Tilapia mossambica (using DPA, EPA and DHA as Index components) manufacture
Eye socket after ocean fish is processed is cleaned, and is 1 with solid-liquid weight ratio：The ratio of 1-1.2 adds in water, regrinds pulp and obtains To homogenate；Homogenate organic solvent is taken to extract 1-3 times, the ratio between organic solvent and homogenate volume are 1：1.2-1.5 collect extraction Liquid, obtains that the extract liquor containing DPA, EPA and DHA grease is spare, and the organic solvent refers to petroleum ether or ether；Extract liquor returns Organic solvent is received, the fish oil containing DPA, EPA and DHA is obtained, the 0.3mol/L sodium methoxide isometric with fish oil is taken to mix, room temperature item Nitrogen charging stirring after ten minutes, adjusts pH value to 7.0-7.2, recycles methanol, obtain the fish oil of esterification under part；To esterification fish oil Carry out molecular distillation, including degassing, pre- thermal distillation and distillation three technical steps, wherein de-airing step in 20-30 DEG C of temperature, be System pressure is de-gassed under conditions of 1-2mbar；Distilation steps are preheated in fish oil with 15-20 kgs/hour of charging rate It is sent into pre-thermal level distiller, in 170-200 DEG C of temperature, system pressure 0.001-0.01mbar, knifing spinner velocity 150-250 It is distilled under conditions of rev/min；Distilation steps are sent into 5-20 kgs/hour of charging rate in distiller, in temperature 250- 350 DEG C, system pressure 0.001-0.01mbar, distill under conditions of 150-250 revs/min of knifing spinner velocity, collect 290- Fraction at 310 DEG C is to get to the compound containing EPA, DHA and DPA of higher degree.
The preparation of 3 present composition of embodiment
Raw material weight proportioning of soup processed：Fish eye socket tissue crushed material or 200-600 parts of extract (in terms of fresh goods weight), flake ball group Knit crushed material or 200-600 parts of extract (in terms of fresh goods weight), 100~300 parts of γ-aminobutyric acid, phosphatidylserine 200 ~500 parts, 50~200 parts of anthocyanidin (either 1-200 parts of 4~12 parts of astaxanthin or procyanidine), (3R, 3'R)-dihydroxy 5~15 parts of base -1-5 parts of beta carotene, lutein and/or lutein ester.
Preparation method：
1st, by weight ratio by fish eye socket tissue crushed material or extract, flake ball tissue crushed material or extract, γ-ammonia Base butyric acid, phosphatidylserine, anthocyanidin (or astaxanthin, procyanidine), (3R, 3'R)-dihydroxy-beta carotene, leaf are yellow Plain ester adds in syrup and stirs evenly after mixing.
2nd, hard, toffee, sandwich, crisp matter, burnt odor (too prince wife), inflation, gel, glue can be made in injection molding on demand after being cooled and shaped The confectionery formats such as base, tabletting, liquid, diaphragm, fancy and chocolate and chocolate, substitute of cocoa fat chocolate and Dai Ke It can the pan works such as fat chocolate, jelly (fruit juice type, fruit pulp type, fruit-flavor type, milk type etc.).
The preparation of 4 present composition of embodiment
Raw material weight proportioning of soup processed：Fish eye socket tissue crushed material or 200-600 parts of extract (in terms of fresh goods weight), flake ball group Knit crushed material or 200-600 parts of extract (in terms of fresh goods weight), 100~400 parts of γ-aminobutyric acid, phosphatidylserine 100 ~500 parts, 50~200 parts of anthocyanidin (either 1-300 parts of 4~12 parts of astaxanthin or procyanidine), (3R, 3'R)-dihydroxy 1~25 part of base -1-10 parts of beta carotene, lutein and/or lutein ester.
Preparation method：Select fish eye socket tissue crushed material or extract, flake ball tissue crushed material or extract, tea ammonia Acid, γ-aminobutyric acid, anthocyanidin (or haematococcus pluvialis extract of procyanidine, astaxanthin-containing), (3R, 3'R)-dihydroxy- The raw material mixing of beta carotene, lutein ester, add in required processing water and 30-45 liquid milks be sufficiently stirred, dissolved, Homogeneous, homogenization pressure 25Mpa, then ultra-high temperature sterilization is carried out, aseptic packaging, through being put in storage after the assay was approved.
The preparation of 5 present composition of embodiment
Raw material weight proportioning of soup processed：Fish eye socket tissue crushed material or 200-600 parts of extract (in terms of fresh goods weight), flake ball group Knit crushed material or 200-600 parts of extract (in terms of fresh goods weight), 100~400 parts of γ-aminobutyric acid, phosphatidylserine 100 ~500 parts, 50~200 parts of anthocyanidin (either 1-200 parts of 4~12 parts of astaxanthin or procyanidine), (3R, 3'R)-dihydroxy 0.6~25 part of base -0.2-10 parts of beta carotene, lutein and/or lutein ester.
Preparation method：Select fish eye socket tissue crushed material or extract, flake ball tissue crushed material or extract, tea ammonia Acid, blueberry extract, stir evenly, ozone sterilization is filling, can directly take after mixing it with water or be added to other food as functional auxiliary material In.
Beneficial effects of the present invention are proved below by way of test example.Flake ball tissue extract use as described below is according to reality The Tilapia mossambica eyeball tissue extract of 1 method of example preparation is applied, fish eye socket tissue extract uses what is prepared according to 2 method of embodiment Tilapia mossambica eye socket tissue extract.
1 fish eyeball tissue of test example and/or fish eye socket tissue alleviate visual fatigue and its related indication observation on probation
3 test groups are set, take flake ball tissue extract, fish eye socket tissue extract as shown in table 2 respectively, in bracket It represents the weight of corresponding fresh fish eyeball tissue, fish eye socket tissue, the big opaque capsule such as is loaded into, for asthenope Examination clothes continuously take 60 days (table 2, which corresponds to, daily to be measured), observe trial effect.
According to《Visual fatigue diagnosis and treatment Consensus of experts》(2014) are diagnosed as visual fatigue patient 144, and symptom hinders including vision Hinder：Near work or reading be not lasting, temporary blurred vision or ghost image occurs；Ophthalmic uncomfortable：Eye is swollen, ophthalmodynia, eye are burnt Feel, shed tears, eye is itched, eye foreign body sense and eye socket pain.Constitutional symptom：Fatiguability has a headache, is dizzy, failure of memory, under memory Drop, anxiety, irritated and other neurosiss symptoms.Age 18-65 Sui, random point 3 groups.Medicine prison guarantorization is eaten according to state [2012] No. 107《Alleviate visual fatigue function evaluation methods》Visual fatigue measuring scale is worked out, is shown in Table 1, calculates before taking, take 60 Its integration reduced rate：Total mark × 100% before (total mark after total mark-treatment before treatment)/treatment, post treatment integral reduced rate >=30% is effective.Symptom integral improves efficient statistical result and is shown in Table 2.
1 visual fatigue measuring scale of table (sxemiquantitative integration method)
Note：" random thoughts " refer to 1-2 times/2 days；" when have " refers to 1-3 times/day；" frequent " refers to>3 times/day
2 symptom integral improvement rate statistical result of table
Crowd's result on trial is shown：Fish eyeball tissue, fish eye socket tissue are respectively provided with the significant effect for alleviating visual fatigue, right Eye caused by visual fatigue is ached, eye is swollen, photophobia, blurred vision, foreign body sensation, the symptoms such as shed tears can play it is a degree of slow Solution acts on, moreover, by after fish eyeball tissue and fish eye socket stitch combinations use, the beneficial eye ingredient that the two is rich in obtains in effect Complementation can play synergistic effect so that the effect for alleviating visual fatigue further promoted.
2 present composition of test example alleviates visual fatigue and its related indication observation on probation
9 test groups are set, take flake ball tissue extract, fish eye socket tissue extract, γ-ammonia as shown in table 3 respectively Base butyric acid, represent in bracket corresponding fresh fish eyeball tissue, fish eye socket tissue, γ-aminobutyric acid weight, be loaded into Big opaque capsule tries to take for asthenope, continuously takes 60 days (table 3, which corresponds to, daily to be measured), observes trial effect.
According to《Visual fatigue diagnosis and treatment Consensus of experts》(2014) are diagnosed as visual fatigue patient 225, and symptom hinders including vision Hinder：Near work or reading be not lasting, temporary blurred vision or ghost image occurs；Ophthalmic uncomfortable：Eye is swollen, ophthalmodynia, eye are burnt Feel, shed tears, eye is itched, eye foreign body sense and eye socket pain.Constitutional symptom：Fatiguability has a headache, is dizzy, failure of memory, under memory Drop, anxiety, irritated and other neurosiss symptoms.Age 18-65 Sui, random point 9 groups.Medicine prison guarantorization is eaten according to state [2012] No. 107《Alleviate visual fatigue function evaluation methods》Visual fatigue measuring scale is worked out, is shown in Table 1.Constitutional symptom carries out individual event Scoring：Decreased attention evaluates (0 point：It can adhere to being absorbed in work or learn 30 minutes；1 point：Occasionally there is decreased attention；2 points：When There is decreased attention；3 points：Often there is decreased attention)；Decrease of memory evaluates (0 point：Yesterday, thing can all be recalled；1 point： Occasionally there is decrease of memory；2 points：When have decrease of memory；3 points：Often there is decrease of memory)；Note：" occasionally having " refers to 1-2 times/2 My god；" when have " refers to 1-3 times/day；" frequent " refers to>3 times/day.Calculating takes 1 day, takes 60 days integration reduced rates：(treatment Total mark after preceding total mark-treatment)/treatment before total mark × 100%, post treatment integral reduced rate >=30% is effective.Symptom Integration improves efficient statistical result and is shown in Table 3.
3 symptom integral of table improves efficient statistical result
Test group 1 is only added to flake ball and fish eye socket tissue extract, and result on trial shows that it has significant alleviate The effect of visual fatigue eyes local symptom, improvement rate reaches 86% after taking 60 days, but it is slower to work, and takes 1 day effective percentage only It is 20%.
Test group 2~9 is added to active constituent gamma-amino fourth on the basis of flake ball and fish eye socket tissue extract Acid, the as a result significantly accelerated remission effect to eyes local symptom can be effective after taking 1 day, and right after taking for a long time The remission effect of eyes local symptom is compared with test group 1 more preferably (contrast test group 1,2 is understood).In addition, add in γ-aminobutyric acid Test group can also be obviously improved attention and memory situation.
From test group 2~9 as can be seen that fish eyeball tissue, fish eye socket tissue and γ-aminobutyric acid were limited in the present invention In ratio range (i.e. 10~1000 parts of fish eyeball tissue, 10~1000 parts of fish eye socket tissue, 10~1000 parts of γ-aminobutyric acid) It is applied in combination, can play the apparent effect for alleviating visual fatigue, to influencing the eyes local symptom of visual fatigue crowd and complete Body symptom has obvious curative effects.Wherein, it is preferably in a proportion of：300~600 parts of fish eyeball tissue, 300~600 parts of fish eye socket tissue, 100~300 parts of γ-aminobutyric acid.

Claims (13)

1. composition for relieving asthenopia, it is characterized in that：Active constituent includes fish eyeball tissue or its extract, fish eye socket tissue Or its extract and γ-aminobutyric acid.
2. composition as described in claim 1, it is characterized in that：The weight proportion of the active constituent is：Fish eyeball tissue 10 ~1000 parts, 10~1000 parts of fish eye socket tissue, 10~1000 parts of γ-aminobutyric acid；Preferably, the weight of the active constituent It matches and is：100~800 parts of fish eyeball tissue, 100~800 parts of fish eye socket tissue, 70~500 parts of γ-aminobutyric acid；Further Preferably, the weight proportion of the active constituent is：300~600 parts of fish eyeball tissue, 300~600 parts of fish eye socket tissue, γ- 100~300 parts of aminobutyric acid；Most preferably, the weight proportion of the active constituent is：Fish eyeball tissue：Fish eye socket tissue： γ-aminobutyric acid=1：1：(0.5~1).
3. composition as claimed in claim 1 or 2, it is characterized in that：The fish eyeball tissue or fish eye socket tissue be selected from yaito tuna, Tuna, stripped tuna, scad, Tilapia mossambica, ray fish, gadus, mackerel, hard squama perch, smelt, salmon, sand lance, red coat, Anglerfish, great white shark, gurnet, walleye pollack, east perch, carp, crucian, black carp, marlin, red porgy, grey mullet, Spanish mackerel, catfish, silver Fish, sunfish, black porgy, hairtail, mandarin fish, zingel, loach, snakeheaded fish, cries aunt fish, is east Peristedion, swordfish, dark at saury Line Fugu, yellowfin tuna, mako shark, yellow croaker, filefish, sole, mouse fish, hilsa herring, Hei Jun fishes, sardine, the spot fin light gill One or more kinds of eyeball tissues of fish or eye socket group in fish, atka mackerel, tilefiss, sea eel, butterfish, spotted maigre It knits.
4. composition as claimed in claim 1 or 2, it is characterized in that：The extract is water extract or alcohol extract.
5. the composition as described in Claims 1 to 4 any one, it is characterized in that：Active constituent further include phosphatidylserine, It is one or two kinds of in anthocyanidin, astaxanthin, procyanidine, lutein, lutein ester, (3R, 3'R)-dihydroxy-beta carotene Above mixture.
6. composition as claimed in any one of claims 1 to 5, wherein, it is characterized in that：It is the active constituent of each weight proportion, adds in Food, health products or the drug that acceptable auxiliary material or complementary ingredient are prepared.
7. composition as claimed in claim 6, it is characterized in that：The food, health products or drug are oral form.
8. composition as claimed in claim 7, it is characterized in that：The food or health products are candy, beverage, biscuit, bread, Jelly or dietary supplements.
9. the preparation method of composition described in claim 1~8 any one, it is characterized in that：Include the following steps：Take each weight The active constituent of proportioning, add in food, health products or drug acceptable auxiliary material or complementary ingredient to get.
10. composition described in claim 1~8 any one is in the food for alleviating visual fatigue, health products or drug is prepared Purposes.
11. purposes as claimed in claim 10, it is characterized in that：The food, health products or drug, which have, alleviates visual fatigue institute The effect of causing eyes local symptom and/or Spirit nerve symptoms of disease.
12. purposes as claimed in claim 11, it is characterized in that：The eyes local symptom is eye is ached, eye is swollen, photophobia, is regarded Object obscures, eye is dry and astringent, foreign body sensation or sheds tears.
13. purposes as claimed in claim 11, it is characterized in that：The Spirit nerve symptoms of disease is decreased attention, memory subtracts It moves back, anxiety or insomnia.
CN201810141540.XA 2018-02-11 2018-02-11 Composition for relieving asthenopia containing flake and γ-aminobutyric acid Pending CN108244640A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810141540.XA CN108244640A (en) 2018-02-11 2018-02-11 Composition for relieving asthenopia containing flake and γ-aminobutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810141540.XA CN108244640A (en) 2018-02-11 2018-02-11 Composition for relieving asthenopia containing flake and γ-aminobutyric acid

Publications (1)

Publication Number Publication Date
CN108244640A true CN108244640A (en) 2018-07-06

Family

ID=62745081

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810141540.XA Pending CN108244640A (en) 2018-02-11 2018-02-11 Composition for relieving asthenopia containing flake and γ-aminobutyric acid

Country Status (1)

Country Link
CN (1) CN108244640A (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1498633A (en) * 2002-11-05 2004-05-26 中国人民解放军军事医学科学院放射医 Oral liquid for treating ophthalmic diseases
CN103131530A (en) * 2012-03-31 2013-06-05 大连工业大学 Preparation method for fish eye socket active grease
CN103535437A (en) * 2013-10-28 2014-01-29 临沂格瑞食品有限公司 Modified milk containing gamma-aminobutyric acid and phosphatidylserine and preparation method thereof
CN106490284A (en) * 2016-11-03 2017-03-15 吉林师范大学博达学院 A kind of candy for alleviating pressure and preparation method thereof
CN107136494A (en) * 2017-06-28 2017-09-08 上海雨山生物科技有限公司 It is a kind of can anti-vision degeneration and skin aging edible health products

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1498633A (en) * 2002-11-05 2004-05-26 中国人民解放军军事医学科学院放射医 Oral liquid for treating ophthalmic diseases
CN103131530A (en) * 2012-03-31 2013-06-05 大连工业大学 Preparation method for fish eye socket active grease
CN103535437A (en) * 2013-10-28 2014-01-29 临沂格瑞食品有限公司 Modified milk containing gamma-aminobutyric acid and phosphatidylserine and preparation method thereof
CN106490284A (en) * 2016-11-03 2017-03-15 吉林师范大学博达学院 A kind of candy for alleviating pressure and preparation method thereof
CN107136494A (en) * 2017-06-28 2017-09-08 上海雨山生物科技有限公司 It is a kind of can anti-vision degeneration and skin aging edible health products

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
国家食品药品监督管理总局等: "《科学食用保健康：保健食品的选择》", 28 February 2015, 中国医药科技出版社 *
李兆龙: "日本EPA和DHA的开发 ", 《今日科技》 *
石赟: "《吃出健康：现代家庭健康膳食指南》", 31 May 2007, 中国妇女出版社 *
金鑫等: "缓解视疲劳功能食品及其功效成分研究进展 ", 《食品科学》 *
陶宁萍等: "提取黄鳍金枪鱼眼窝肉鱼油的方法比较研究 ", 《中国油脂》 *

Similar Documents

Publication Publication Date Title
CN106615178B (en) DHA algae oil solid beverage
CN108354175A (en) Composition for relieving asthenopia containing flake, theanine and γ-aminobutyric acid
CN101595977B (en) Formula food beneficial to eye health and application thereof
CN102669377A (en) Lutein ester soft candy and production method thereof
CN108835262B (en) Modified milk powder for improving memory and preparation method thereof
CN110663872A (en) Full-nutrient meal replacement weight-losing food, preparation method and eating method
CN102742656B (en) Milky tea relieving asthenopia and preparation method thereof
CN108703180A (en) A kind of high fibre, low-carbon, life ketone biscuit and preparation method thereof high in fat
CN101731597B (en) Blueberry fish oil capsule
CN102429307A (en) Low-calorie and total-nutrient beverage and preparation method thereof
AU2020102055A4 (en) Brain-building gel candy and preparation method thereof
CN108294305A (en) Alleviation visual fatigue composition containing procyanidine
CN102113566A (en) Buckwheat walnut milk and preparation method thereof
US8663716B2 (en) Composition for treatment of aesthenopia
CN108185427A (en) Composition for relieving asthenopia containing flake, theanine and phosphatidylserine
CN108159036A (en) Composition for relieving asthenopia containing theanine, phosphatidylserine and procyanidine
CN108078972A (en) Purposes of the γ-aminobutyric acid in the food for alleviating visual fatigue, health products or drug is prepared
CN108354918A (en) Composition for relieving asthenopia containing theanine, γ-aminobutyric acid and procyanidine
CN104543274B (en) A kind of soft sweets containing DHA
CN108324705A (en) Composition for relieving asthenopia containing theanine, γ-aminobutyric acid and anthocyanidin
CN108042652A (en) Composition for relieving asthenopia containing matrimony vine, chrysanthemum and γ-aminobutyric acid
CN108261472A (en) Composition for relieving asthenopia containing matrimony vine, chrysanthemum, γ-aminobutyric acid and theanine
CN108338364A (en) Composition for relieving asthenopia containing theanine and astaxanthin
CN108078974A (en) Composition for relieving asthenopia containing theanine, γ-aminobutyric acid and astaxanthin
CN108244640A (en) Composition for relieving asthenopia containing flake and γ-aminobutyric acid

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180706

RJ01 Rejection of invention patent application after publication