CN108835262B - Modified milk powder for improving memory and preparation method thereof - Google Patents
Modified milk powder for improving memory and preparation method thereof Download PDFInfo
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Abstract
The invention provides a modified milk powder for improving memory and a preparation method thereof, and the modified milk powder comprises 40-50 parts of full-cream milk powder or full-cream emulsion of the same dry matter, 17-25 parts of skim milk powder or skim milk of the same dry matter, 15-23 parts of whey powder, 5-15 parts of glucose syrup solid or lactose, 2-5 parts of vegetable oil, 0.2-3 parts of fish oil extract, 0.1-1 part of hydrolyzed yolk powder, 0.01-2 parts of medicinal and edible congener, 0.01-3 parts of dietary fiber, 0.2-2 parts of compound mineral, 0.01-0.15 part of compound vitamin, 0.01-0.5 part of sialic acid, 0.025-0.6 part of phosphatidylserine and 0.002-0.008 part of zeaxanthin. The prepared milk powder can exert respective functions in vivo through various components and simultaneously promote the functions in a mutual and synergistic manner, effectively supply nutrition and oxygen to the central nervous system of the brain, enhance the memory capacity of the brain and comprehensively improve the brain function.
Description
Technical Field
The invention relates to the technical field of modified milk powder, in particular to modified milk powder for improving memory and a preparation method thereof.
Background
Alzheimer's Disease (AD), also called senile dementia, is a degenerative disease of the central nervous system, with an insidious onset and a chronic progressive course, and is one of the most common types of senile dementia. With the aging population, the incidence of senile dementia (AD) also increases, and is the fourth leading cause of death of the elderly following tumors, heart diseases, and cerebrovascular diseases. At present, the medicines for treating senile dementia mainly comprise cholinesterase inhibitors and cerebral vessel dilators, and the medicines are too much eaten and potentially dangerous to cause adverse reactions.
The brain is the most precise organ for human body to perform thinking activities, and is responsible for the functions of human learning, thinking, memory and the like. Wherein, the memory is the reappearance of the former things and experience, and comprises four basic processes of memory, keeping, recognization and recalling. Memory impairment is a general impairment of the above four processes. The light person shows that the memory of the recent thing is weakened, such as forgetting the book and the person who just saw. In severe cases, the memory will also decline, for example, the learning experience will not be recalled.
Hypomnesia is common in the elderly, mostly due to neurasthenia and senile dementia. The memory deterioration of middle-aged people and teenagers is far less than that of the old, and is generally caused by high mental stress caused by factors such as learning and life or nerve fatigue caused by continuous brain overuse. Therefore, it is very important to enhance the nutrition and oxygen supply to the central nervous system of the brain. The source of brain function lies in the activity of brain neurons, the supply of energy to neurons, essential nutrients, and neurotransmitter interactions between neurons, largely determining the vitality and cognitive level of the brain.
Therefore, the modified milk powder for improving the memory is developed, and has important value and wide market, and is suitable for the patients with memory impairment at each stage to eat.
Disclosure of Invention
The invention aims to provide modified milk powder for improving memory, which solves the problem of memory weakness in each stage and enhances nutrition and oxygen supply to a central nervous system of a brain.
In order to achieve the purpose, the invention provides modified milk powder for improving memory, which comprises 40-50 parts of whole milk powder or whole milk containing dry matter equal to 40-50 parts of whole milk powder by weight, 17-25 parts of skim milk powder or skim milk containing dry matter equal to 17-25 parts of skim milk powder by weight, 15-23 parts of whey powder, 5-15 parts of glucose syrup solid or lactose, 2-5 parts of vegetable oil, 0.2-3 parts of fish oil extract, 0.1-1 part of hydrolyzed yolk powder, 0.01-2 parts of medicinal and edible congener, 0.01-3 parts of dietary fiber, 0.2-2 parts of composite mineral substance, 0.01-0.15 part of composite vitamin, 0.01-0.5 part of sialic acid, 0.025-0.6 part of phosphatidylserine and 0.002-0.008 part of zeaxanthin.
Further, the whole milk powder or the whole milk, the skim milk powder or the skim milk and the whey powder are all made of cow milk or goat milk; wherein the dry matter content in the full-cream milk powder is 97%, and the dry matter content in the full-cream milk is 11.7%; the dry matter content in the skim milk powder is 96%, and the dry matter content in the skim milk is 11.7%.
Further, the vegetable oil is one or more of corn oil, rapeseed oil, sunflower seed oil and coconut oil.
Further, the fish oil extract is an oily liquid or powdery product prepared by heating and cooking, squeezing, centrifuging, purifying, decoloring and deodorizing marine fish, wherein the marine fish comprises one or more of salmon, sardine and tuna.
Furthermore, the dietary fiber is one or more of fructo-oligosaccharide, inulin, yeast beta-glucan or oat beta-glucan.
Furthermore, the medicinal and edible congee is a powdery product prepared from one or more of rhizoma polygonati, Chinese yam, fructus alpiniae oxyphyllae, poria cocos, Chinese dates, spina date seeds, arillus longan, wolfberry fruits and walnut kernels.
The invention also provides a preparation method of the modified milk powder for improving memory, and the preparation method is a dry-wet composite process or a dry-mixing process.
Further, the dry-wet composite process specifically comprises the following steps:
the method comprises the following steps: preparation of medicinal and edible congeners: pulverizing medicinal and edible materials at a predetermined ratio by a pulverizer, placing the pulverized materials in a container, adding ethanol, soaking, extracting, mixing the ethanol extractive solutions, and concentrating until there is no alcohol smell; evaporating ethanol from the residue, soaking in water, decocting the soaking solution, filtering to remove the raw materials, and collecting the decoction; mixing the concentrated ethanol extractive solution and the decoction, spray drying, and sieving with 60-80 mesh sieve to obtain powder product;
step two: preparing materials: mixing whole milk powder, skim milk powder, whey powder, glucose syrup solid or lactose, medicinal and edible congeners, dietary fiber and hydrolyzed egg yolk powder according to a predetermined proportion, adding the mixture into purified water with the weight being 3-4 times that of the mixture and the temperature being 40-50 ℃, or mixing the whey powder, the glucose syrup solid or lactose, the medicinal and edible congeners, the dietary fiber and the hydrolyzed egg yolk powder according to a predetermined proportion, directly adding the mixture into the whole milk and the skim milk with the temperature being 40-50 ℃, and pumping the obtained first mixed material into a temporary storage tank I after uniformly stirring; adding the fish oil extract in a predetermined ratio into the vegetable oil in a predetermined ratio, uniformly mixing with the first mixed material to obtain a second mixed material, and pumping the second mixed material into a temporary storage tank II; dissolving the vitamin complex and the mineral complex in purified water of 10 times and 40-50 ℃ respectively according to a predetermined proportion, uniformly mixing the dissolved vitamin complex and the mineral complex with the second mixed material, and pumping the obtained third mixed material into a temporary storage tank III;
step three: shearing and filtering: pouring the third mixed material in the temporary storage tank III into a high-speed shearing tank through a proportioning pump or directly, stirring for 10 minutes, and then pumping the third mixed material into a standardized cylinder through a duplex filter to obtain a fourth mixed material;
step four: homogenizing: homogenizing the fourth mixed material to obtain a fifth mixed material;
step five: and (3) sterilization: sterilizing the fifth mixed material;
step six: concentration: concentrating the sterilized fifth mixed material to 20-24 degrees Be to obtain a sixth mixed material;
step seven: spray drying: spray drying the sixth mixed material to obtain a seventh mixed material;
step eight: bean jelly: cooling the seventh mixed material to room temperature by a fluidized bed, wherein the water content in the material is 2.5-4.0%;
step nine: mixing: adding phosphatidylserine, zeaxanthin and sialic acid according to a preset proportion, and uniformly mixing in a three-dimensional mixer to obtain the modified milk powder.
Further, the dry mixing process specifically comprises the following steps:
step A: preparation of medicinal and edible congeners: pulverizing medicinal and edible materials at a predetermined ratio by a pulverizer, placing the pulverized materials in a container, adding ethanol, soaking, extracting, mixing the ethanol extractive solutions, and concentrating until there is no alcohol smell; evaporating ethanol from the residue, soaking in water, decocting the soaking solution, filtering to remove the raw materials, and collecting the decoction; mixing the concentrated ethanol extractive solution and the decoction, spray drying, and sieving with 60-80 mesh sieve to obtain powder product;
and B: first-stage dry mixing, namely putting whole milk powder, medicinal and edible congeners, fish oil extracts, hydrolyzed yolk powder, dietary fibers, phosphatidylserine, sialic acid, zeaxanthin, compound vitamins and compound mineral substances in a predetermined proportion into a three-dimensional mixer, uniformly mixing to obtain a first material, and conveying the first material into a high-speed mixer through dense phase;
and C: and (2) performing second-stage dry mixing, namely putting the skimmed milk powder, whey powder, glucose syrup solid or lactose and embedded vegetable oil powder into a high-speed mixer according to a preset proportion and uniformly mixing with the first material to obtain the modified milk powder.
In recent years, research finds that the omega-3 polyunsaturated fatty acids such as EPA, DHA and the like have the effect of improving the brain function, and particularly have the effect of improving the brain memory.
The hydrolyzed yolk powder contains rich lecithin, can generate rich choline acetate after being decomposed by enzyme, enters blood and quickly reaches brain tissues, and can enhance the memory of human bodies. The hydrolyzed yolk powder can also activate the motive power of the skeleton and promote the elongation of the skeleton; promote the calcium deposition of the bone and maintain the balance of the bone components.
In the medicinal and edible materials, the fructus alpiniae oxyphyllae extract can obviously improve the learning and memory ability and has the beneficial effect on intelligence. The fructus Jujubae contains saccharide, protein, fat, and organic acid, and has brain tonifying effect. Longan is also called longan, has warm and sweet nature and flavor, can benefit heart and spleen and tonify qi and blood; has good nourishing and invigorating effects, and can be used for treating insomnia, amnesia, palpitation due to fright, vertigo, and asthenia after illness. Walnut kernel contains more protein and unsaturated fatty acid necessary for human nutrition, and these components are important substances required for brain tissue cell metabolism, and can nourish brain cells and enhance brain function.
Phosphatidylserine, also known as complex nervonic acid, extracted from natural soybean oil residue is an active substance of cell membranes, and is particularly present in brain cells. The functional components mainly improve nerve cell function, regulate the conduction of nerve pulse and enhance brain memory function, and the lipophilic components can quickly enter the brain through a blood brain barrier after being absorbed due to strong lipophilicity, thereby playing the roles of relieving blood vessel smooth muscle cells and increasing blood supply of the brain.
Sialic acid, known as N-acetylneuraminic acid, is a derivative of a 9-carbon monosaccharide which imparts to saliva a smooth sensory negatively charged ion. It not only has the function of inducing invasive pathogenic bacteria, but also is currently recognized as a transmitter of ganglioside and is a component of the brain. Sialic acid in breast milk is directly related to the level of mental development in early childhood, and promotes the speed of information transmission between the brain neurons, and the speed of brain responses through interaction with the cell membrane and synapses of the brain. Therefore, sialic acid can be supplemented, brain intelligence development can be increased, and memory can be improved.
The chemical name of zeaxanthin is (3R,3' R) -dihydroxy-beta-carotene, zeaxanthin is only one of 2 carotenoids in the lens, and has 11 conjugated double bonds in the molecule, and the tail end group has hydroxyl group, so that the zeaxanthin has strong antioxidant capacity. Research shows that the possibility of cataract of the crowd with high zeaxanthin intake can be reduced by 19-22% compared with the possibility of cataract of the crowd with low intake. Preventing senile macular region lesion. Zeaxanthin has high nutritive value, and can be converted into bioactive vitamin A in human liver after being eaten, and the vitamin A can promote brain development. Zeaxanthin affects an important factor of the optical density of Macular Pigment (MPOD), which is related to cognition in people with mild cognitive impairment, and the optical density of Macular Pigment (MPOD) is the only factor related to the visual space and interpretability of healthy elderly.
The invention has the following beneficial effects:
the invention provides a modulated formula milk powder which is prepared from fish oil extract, hydrolyzed yolk powder, phosphatidylserine, sialic acid, medicinal and edible congeners, zeaxanthin, vitamins (A, E, C) and trace elements (calcium, iron, zinc, magnesium and selenium) in a specific proportion. The modified milk powder has effects of improving memory, increasing skeleton density and preventing visual deterioration.
In addition to the objects, features and advantages described above, other objects, features and advantages of the present invention are also provided. The present invention will be described in further detail below.
Detailed Description
The following is a detailed description of embodiments of the invention, but the invention can be implemented in many different ways, as defined and covered by the claims.
Example 1:
the modified milk powder for improving memory comprises the following raw materials in percentage by weight: 42.5 parts of defatted milk powder: 20 parts of bovine whey powder: 17.5 parts of glucose syrup solid: 12 parts and corn oil: 3 parts of hydrolyzed egg yolk powder: 0.7 part of fish oil extract: 1.3 parts of inulin: 1.14 parts of walnut kernel: 0.1 part of red date: 0.3 part of longan pulp: 0.1 part of fructus alpiniae oxyphyllae: 0.2 part of composite mineral substance: 1 part of compound vitamin: 0.06 part, phosphatidylserine: 0.04 part, sialic acid: 0.055 parts, zeaxanthin: 0.005 part.
The compound vitamin is prepared by mixing the following components in percentage by weight: 70%, vitamin a acetate: 0.67%, cholecalciferol: 0.011%, dl-alpha-tocopherol acetate: 29.319 percent.
The composite mineral substance is prepared by mixing the following components in percentage by weight: 81.396%, ferrous sulfate: 1.8% and zinc sulfate: 0.8%, magnesium sulfate: 16%, sodium selenite: 0.004%.
The modified milk powder of the embodiment is prepared by adopting a dry-wet method composite process, and specifically comprises the following steps:
the method comprises the following steps: preparation of medicinal and edible congeners: pulverizing semen Juglandis, fructus Jujubae, arillus longan, and fructus Alpinae Oxyphyllae at a predetermined ratio with a pulverizer, placing the pulverized raw materials in a container, adding 60-80% ethanol 3-5 times of the raw materials, soaking, extracting for 2 times, mixing the ethanol extractive solutions, and concentrating until there is no ethanol smell; removing ethanol from the residue, soaking in 6-8 times of water, decocting for 30-60min, filtering to remove the residue, and collecting decoction; mixing the concentrated ethanol extractive solution and the decoction, spray drying, and sieving with 60-80 mesh sieve to obtain medicinal and edible powder.
Step two: mixing whole milk powder, skimmed milk powder, whey powder, glucose syrup solid, inulin, medicinal and edible congeners and hydrolyzed yolk powder according to a predetermined proportion, adding 3-5 times of purified water with the weight of 40-50 ℃, uniformly stirring to obtain a first mixed material, and pumping the first mixed material into a temporary storage tank I; adding the fish oil extract in a predetermined ratio into corn oil in a predetermined ratio, uniformly mixing with the first mixed material to obtain a second mixed material, and pumping the second mixed material into a temporary storage tank II; dissolving the vitamin complex and the mineral complex in purified water with the temperature of 8-10 times 45 ℃ respectively according to a predetermined proportion, uniformly mixing the dissolved vitamin complex and the mineral complex with the second mixed material, and pumping the obtained third mixed material into a temporary storage tank III.
Step three: shearing and filtering: and (3) pouring the third mixed material in the temporary storage tank III into a high-speed shearing tank through a proportioning pump or directly, stirring for 10 minutes, and then pumping into a standardized cylinder through a duplex filter to obtain a fourth mixed material. The standardized jar stirring should be kept stirring state continuously, ensure that the batching milk mixes evenly and prevent the batching layering.
Step four: homogenizing: and homogenizing the fourth mixed material at 60-65 ℃ and 18-20MPa to obtain a fifth mixed material.
Step five: and (3) sterilization: and (4) sterilizing the fifth mixed material at the sterilization temperature of 89 +/-2 ℃ for 20-25 seconds.
Step six: concentration: and concentrating the sterilized fifth mixed material to 20 DEG Be to obtain a sixth mixed material.
Step seven: spray drying: and spray drying the sixth mixed material to obtain a seventh mixed material.
Step eight: bean jelly: and cooling the seventh mixed material to room temperature by the fluidized bed.
Step nine: mixing: adding phosphatidylserine, sialic acid and zeaxanthin according to a predetermined proportion into a three-dimensional mixer, and uniformly mixing to obtain the modified milk powder.
The modified milk powder of the embodiment can be correspondingly packaged according to actual requirements, and specifically adopts the steps of filling nitrogen or nitrogen mixed with carbon dioxide in vacuum for modified atmosphere packaging to obtain a final packaged product, wherein the label is MKP-1 and is used as a test sample;
example 2:
the modified milk powder for improving memory comprises the following raw materials in percentage by weight: 331.6 parts (equivalent to 40 parts of full-fat goat milk powder), and skim goat milk: 180.5 parts (equivalent to 22 parts of defatted goat milk powder), goat whey powder: 18.3 parts, lactose: 8 parts of fructo-oligosaccharide: 2 parts and corn oil: 4 parts of hydrolyzed egg yolk powder: 0.9 part, rhizoma polygonati: 0.5 part of wolfberry fruit: 0.2 part of poria cocos: 0.1 part of Chinese yam: 0.2 part of fish oil extract: 2 parts of composite minerals: 1 part of compound vitamin: 0.1 part, phosphatidylserine: 0.4 part, sialic acid: 0.292 parts, zeaxanthin: 0.008 parts.
The compound vitamin is prepared by mixing the following components in percentage by weight: 80%, vitamin a acetate: 0.4%, cholecalciferol: 0.01%, dl- α -tocopherol acetate: 19.59 percent.
The composite mineral substance is prepared by mixing the following components in percentage by weight: 81.396%, ferrous sulfate: 1.8% and zinc sulfate: 0.8%, magnesium sulfate: 16%, sodium selenite: 0.004%.
The modified milk powder for improving the memory is prepared by adopting a dry-wet composite process, and specifically comprises the following steps:
the method comprises the following steps: preparation of medicinal and edible congeners: pulverizing rhizoma Polygonati, fructus Lycii, Poria, and rhizoma Dioscoreae at a predetermined ratio by a pulverizer, placing the pulverized raw materials in a container, adding 60-80% ethanol 3-5 times the weight of the raw materials, soaking, extracting for 2 times, mixing the ethanol extractive solutions, and concentrating until there is no alcohol smell; removing ethanol from the residue, soaking in 6-8 times of water, decocting for 30-60min, filtering to remove the residue, and collecting decoction; mixing the concentrated ethanol extractive solution and the decoction, spray drying, and sieving with 60-80 mesh sieve to obtain medicinal and edible powder.
Step two: mixing whey powder, glucose syrup solid or lactose, medicinal and edible congeners, dietary fiber and hydrolyzed yolk powder according to a predetermined proportion, directly adding the mixture into full-fat goat milk and defatted goat milk at 40-50 ℃, and pumping the first mixed material obtained after uniformly stirring into a temporary storage tank I; adding the fish oil extract in a predetermined ratio into corn oil in a predetermined ratio, uniformly mixing with the first mixed material to obtain a second mixed material, and pumping the second mixed material into a temporary storage tank II; dissolving the vitamin complex and the mineral complex in purified water with the temperature of 8-10 times 45 ℃ respectively according to a predetermined proportion, uniformly mixing the dissolved vitamin complex and the mineral complex with the second mixed material, and pumping the obtained third mixed material into a temporary storage tank III.
Step three: shearing and filtering: and (3) pouring the third mixed material in the temporary storage tank III into a high-speed shearing tank through a proportioning pump or directly, stirring for 10 minutes, and then pumping into a standardized cylinder through a duplex filter to obtain a fourth mixed material. The standardized jar stirring should be kept stirring state continuously, ensure that the batching milk mixes evenly and prevent the batching layering.
Step four: homogenizing: and homogenizing the fourth mixed material at 60-65 ℃ and 18-20MPa to obtain a fifth mixed material.
Step five: and (3) sterilization: and (4) sterilizing the fifth mixed material at the sterilization temperature of 89 +/-2 ℃ for 20-25 seconds.
Step six: concentration: and concentrating the sterilized fifth mixed material to 20 DEG Be to obtain a sixth mixed material.
Step seven: spray drying: and spray drying the sixth mixed material to obtain a seventh mixed material.
Step eight: bean jelly: and cooling the seventh mixed material to room temperature by the fluidized bed.
Step nine: mixing: adding phosphatidylserine, sialic acid and zeaxanthin according to a predetermined proportion into a three-dimensional mixer, and uniformly mixing to obtain the modified milk powder.
The modified milk powder of the embodiment can be correspondingly packaged according to actual requirements, and specifically adopts the steps of filling nitrogen or nitrogen mixed with carbon dioxide in vacuum for modified atmosphere packaging to obtain a final packaged product, wherein the label is MKP-2.
Example 3:
the modified milk powder for improving memory comprises the following raw materials in percentage by weight: 48 parts of degreased milk powder: 18 parts, bovine whey powder 15 parts, lactose: 9.84 parts, corn oil: 3 parts of hydrolyzed egg yolk powder: 1 part, yeast beta-glucan: 1.8 parts of Chinese yam: 0.1 part of wild jujube seed: 0.3 part of longan pulp: 0.2 part of fructus alpiniae oxyphyllae: 0.1 part, fish oil extract: 0.88 parts of composite mineral substance: 1.5 parts of compound vitamin: 0.06 part, phosphatidylserine: 0.2 part, sialic acid: 0.016 parts, zeaxanthin: 0.004 portion.
The compound vitamin is prepared by mixing the following components in percentage by weight: 70%, vitamin a acetate: 0.67%, cholecalciferol: 0.011%, dl-alpha-tocopherol acetate: 29.319 percent.
The composite mineral substance is prepared by mixing the following components in percentage by weight: 86% and ferrous sulfate: 1.4% and zinc sulfate: 0.596%, magnesium sulfate: 12%, sodium selenite: 0.04 percent.
The modified milk powder for improving the memory is prepared by adopting a dry mixing process, and specifically comprises the following steps:
step A: preparation of medicinal and edible congeners: pulverizing rhizoma Dioscoreae, semen Ziziphi Spinosae, arillus longan, and fructus Alpinae Oxyphyllae at a predetermined ratio with a pulverizer, placing the pulverized raw materials in a container, adding 60-80% ethanol 3-5 times the weight of the raw materials, soaking, extracting for 2 times, mixing the ethanol extractive solutions, and concentrating until there is no ethanol smell; removing ethanol from the residue, soaking in 6-8 times of water, decocting for 30-60min, filtering to remove the residue, and collecting decoction; mixing the concentrated ethanol extractive solution and the decoction, spray drying, and sieving with 60-80 mesh sieve to obtain medicinal and edible powder.
And B: first-stage dry mixing, namely putting whole milk powder, hydrolyzed yolk powder, medicinal and edible congeners, fish oil extract, yeast beta-glucan, phosphatidylserine, zeaxanthin, sialic acid, compound vitamin and compound mineral substance in a predetermined proportion into a three-dimensional mixer to be uniformly mixed to obtain a first material, and conveying the first material into a high-speed mixer through dense phase.
And C: and (2) performing second-stage dry mixing, namely putting the degreased milk powder, the whey powder, the glucose syrup solid and the embedded corn oil powder (prepared by mixing the corn oil with the predetermined proportion in the formula and part of the whey powder in the formula and then performing spray drying) into a high-speed mixer and uniformly mixing with the first material to obtain the modified milk powder.
The modified milk powder is subjected to modified atmosphere packaging by filling nitrogen or carbon dioxide in vacuum to obtain a final packaged product, wherein the label is MKP-3;
the results of the tests on the packaged products of examples 1, 2 and 3 are shown in Table 1
TABLE 1
Comparative example 1: (not containing fish oil extract)
The full-fat milk powder comprises the following components: 42.5 parts of defatted milk powder: 20 parts of bovine whey powder: 18.9 parts, glucose syrup solid: 12 parts and corn oil: 3 parts of hydrolyzed egg yolk powder: 0.7 part of inulin: 1 part of walnut kernel: 0.1 part of red date: 0.3 part of longan pulp: 0.1 part of fructus alpiniae oxyphyllae: 0.2 part of composite mineral substance: 1 part of compound vitamin: 0.1 part, phosphatidylserine: 0.04 part, sialic acid: 0.055 parts, zeaxanthin: 0.005 part.
The compound vitamin is prepared by mixing the following components in percentage by weight: 80%, vitamin a acetate: 0.4%, cholecalciferol: 0.01%, dl- α -tocopherol acetate: 19.59 percent.
The composite mineral substance is prepared by mixing the following components in percentage by weight: 81.396%, ferrous sulfate: 1.8% and zinc sulfate: 0.8%, magnesium sulfate: 16%, sodium selenite: 0.004%.
Comparative example 2: (without homology of medicine and food)
The full-fat milk powder comprises the following components: 42.5 parts of defatted milk powder: 20 parts of bovine whey powder: 18.3 parts, glucose syrup solid: 12 parts and corn oil: 3 parts of hydrolyzed egg yolk powder: 0.7 part of fish oil extract: 1.3 parts of inulin: 1 part of composite mineral substance: 1 part of compound vitamin: 0.1 part, phosphatidylserine: 0.04 part, sialic acid: 0.055 parts, zeaxanthin: 0.005 part.
The compound vitamin is prepared by mixing the following components in percentage by weight: 80%, vitamin a acetate: 0.4%, cholecalciferol: 0.01%, dl- α -tocopherol acetate: 19.59 percent.
The composite material is prepared by mixing the following components in percentage by weight: 81.396%, ferrous sulfate: 1.8% and zinc sulfate: 0.8%, magnesium sulfate: 16%, sodium selenite: 0.004%.
Comparative example 3: (zeaxanthin-free)
The full-fat milk powder comprises the following components: 42.5 parts of defatted milk powder: 20 parts of bovine whey powder: 17.605 parts, glucose syrup solid: 12 parts and corn oil: 3 parts of hydrolyzed egg yolk powder: 0.7 part of fish oil extract: 1.3 parts of inulin: 1 part of walnut kernel: 0.1 part of red date: 0.3 part of longan pulp: 0.1 part of fructus alpiniae oxyphyllae, 0.2 part of fructus alpiniae oxyphyllae, 1 part of compound mineral substance, 0.1 part of compound vitamin, 0.04 part of phosphatidylserine and 0.055 part of sialic acid.
The compound vitamin is prepared by mixing the following components in percentage by weight: 80%, vitamin a acetate: 0.4%, cholecalciferol: 0.01%, dl- α -tocopherol acetate: 19.59 percent.
The composite mineral substance is prepared by mixing the following components in percentage by weight: 81.396%, ferrous sulfate: 1.8% and zinc sulfate: 0.8%, magnesium sulfate: 16%, sodium selenite: 0.04 percent.
The above comparative examples were prepared in the same manner as in the examples.
The results of the tests on the packaged products of comparative examples 1, 2 and 3 according to the invention are shown in Table 2
TABLE 2
Clinical trial experiment: the following clinical trial describes the effect of the modified milk powder for improving memory of the invention on improving memory of the middle-aged and the elderly.
350 cases of healthy middle-aged and old people with mild memory deterioration are collected and subjected to clinical trial feeding tests, and the age is 50-70 years old; a subject: subjects did not receive similar tests and were not taking items related to the function of the subjects for a short period of time. After a first memory quotient test is carried out on the test subject before the test sample is taken, the test subject is randomly divided into a test food group, a comparative example group and a control group according to a memory quotient by a double-blind method, and the balance test is carried out by considering culture level, age and the like as much as possible. The prepared formula milk powder prepared by the invention of example 1(MKP-1), example 2(MKP-2), example 3(MKP-3), comparative example 1 (MKP-3), comparative example 2 and comparative example 3 is additionally and respectively used for intervention test feeding, and the prepared formula milk powder is taken twice in 1 day, and each group respectively takes 25 g of the prepared milk powder for improving memory in the morning and evening, and the time is 45 days. The clinical trial results are shown in table 3.
Table 3: comparative table of the cases of the test group 1, test group 2, test group 3, comparative example 1, comparative example 2, comparative example 3, and blank control group
TABLE 3
And (3) injecting: no difference between P > 0.05: p < 0.05 differential between groups: the difference between the two groups of P < 0.01 is significant.
And (4) conclusion: as can be seen from Table 3, the results of the clinical trial tests were significantly better in the test group 1(MKP-1), the test group 2(MKP-1), and the test group 3(MKP-3) than in the control group with a normal diet. Compared with a blank control group, after eating the modified milk powder for improving the memory, memory indexes such as pointing memory, associative learning, image free memory, meaningless image recognization, portrait characteristics and obvious associative memory are obviously different from those before eating, so that the modified milk powder for improving the memory provided by the invention has obvious effect of improving the memory of middle-aged and old people. From the above results, it can be seen that the clinical trial test results of the test group 1(MKP-1) are all better than those of the comparative example 1 without fish oil extract, the comparative example 2 without homology of medicine and food and the control group 1, the control group 2 and the control group 3 without the formulation of corn gluten proportion 3, while the clinical trial test results of the control group 1, the control group 2 and the control group 3 with the formulations of the comparative example 1, the comparative example 2 and the comparative example 3 are obviously better than those of the blank control group with normal diet. It can be seen that the fish oil extract, the medicinal and edible source, and zeaxanthin all play important roles in the overall formulation. The modified milk powder for improving memory provided by the invention has a great improvement effect on the memory of middle-aged and elderly people through the synergistic effect among the components, and various memory improving nutritional ingredients exert respective functions in vivo and are mutually synergistic and mutually promoted, so that the nutrition of a central nervous system of a brain is effectively supplied, the information transmission speed is increased, the memory capability of the brain is enhanced, and the brain function is comprehensively improved. The modified milk powder of the invention is suitable for people with memory impairment of all ages to eat, has obvious effect of improving memory of all ages, and simultaneously has the effects of relieving eye asthenopia and maintaining bone density.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. The modified milk powder for improving memory is characterized by being suitable for middle-aged and elderly people and comprising 40-50 parts of whole milk powder or whole milk containing dry matter equal to 40-50 parts of whole milk powder by weight, 17-25 parts of skim milk powder or skim milk containing dry matter equal to 17-25 parts of skim milk powder by weight, 15-23 parts of whey powder, 5-15 parts of glucose syrup solid or lactose, 2-5 parts of vegetable oil, 0.2-3 parts of fish oil extract, 0.1-1 part of hydrolyzed yolk powder, 0.01-2 parts of medicinal and edible congener, 0.01-3 parts of dietary fiber, 0.2-2 parts of composite mineral substance, 0.01-0.15 part of composite vitamin, 0.01-0.5 part of sialic acid, 0.025-0.6 part of phosphatidylserine and 0.002-0.008 part of zeaxanthin; the medicinal and edible congee is a powdery product prepared from one or more of rhizoma polygonati, Chinese yam, fructus alpiniae oxyphyllae, poria cocos, Chinese dates, spina date seeds, arillus longan, fructus lycii and walnut kernels.
2. The modified milk powder for improving memory according to claim 1, wherein the whole milk powder or whole milk, the skim milk powder or skim milk and the whey powder are made of cow's milk or goat's milk; wherein the dry matter content in the full-cream milk powder is 97%, and the dry matter content in the full-cream milk is 11.7%; the dry matter content in the skim milk powder is 96%, and the dry matter content in the skim milk is 11.7%.
3. The modulated milk powder for improving memory according to claim 1, wherein the vegetable oil is one or more of corn oil, rapeseed oil, sunflower seed oil and coconut oil.
4. The modified milk powder for improving memory according to claim 1, wherein the fish oil extract is an oily liquid or powder product prepared by cooking, squeezing, centrifuging, purifying, decolorizing, and deodorizing marine fish including one or more of salmon, sardine, and tuna.
5. The modified milk powder for improving memory according to claim 1, wherein the dietary fiber is one or more of fructo-oligosaccharide, inulin, yeast beta-glucan or oat beta-glucan.
6. The method for preparing a modified milk powder for improving memory according to any one of claims 1 to 5, wherein the preparation method is a dry-wet compounding process or a dry-mixing process.
7. The preparation method of the modified milk powder for improving memory according to claim 6, wherein the dry-wet compounding process specifically comprises the following steps:
the method comprises the following steps: preparation of medicinal and edible congeners: pulverizing medicinal and edible materials at a predetermined ratio by a pulverizer, placing the pulverized materials in a container, adding ethanol, soaking, extracting, mixing the ethanol extractive solutions, and concentrating until there is no alcohol smell; evaporating ethanol from the residue, soaking in water, decocting the soaking solution, filtering to remove the raw materials, and collecting the decoction; mixing the concentrated ethanol extractive solution and the decoction, spray drying, and sieving with 60-80 mesh sieve to obtain powder product;
step two: preparing materials: mixing whole milk powder, skim milk powder, whey powder, glucose syrup solid or lactose, medicinal and edible congeners, dietary fiber and hydrolyzed egg yolk powder according to a predetermined proportion, adding the mixture into purified water with the weight being 3-4 times that of the mixture and the temperature being 40-50 ℃, or mixing the whey powder, the glucose syrup solid or lactose, the medicinal and edible congeners, the dietary fiber and the hydrolyzed egg yolk powder according to a predetermined proportion, directly adding the mixture into the whole milk and the skim milk with the temperature being 40-50 ℃, and pumping the obtained first mixed material into a temporary storage tank I after uniformly stirring; adding the fish oil extract in a predetermined ratio into the vegetable oil in a predetermined ratio, uniformly mixing with the first mixed material to obtain a second mixed material, and pumping the second mixed material into a temporary storage tank II; dissolving the vitamin complex and the mineral complex in purified water of 10 times and 40-50 ℃ respectively according to a predetermined proportion, uniformly mixing the dissolved vitamin complex and the mineral complex with the second mixed material, and pumping the obtained third mixed material into a temporary storage tank III;
step three: shearing and filtering: pouring the third mixed material in the temporary storage tank III into a high-speed shearing tank through a proportioning pump or directly, stirring for 10 minutes, and then pumping the third mixed material into a standardized cylinder through a duplex filter to obtain a fourth mixed material;
step four: homogenizing: homogenizing the fourth mixed material to obtain a fifth mixed material;
step five: and (3) sterilization: sterilizing the fifth mixed material;
step six: concentration: concentrating the sterilized fifth mixed material to 20-24 degrees Be to obtain a sixth mixed material;
step seven: spray drying: spray drying the sixth mixed material to obtain a seventh mixed material;
step eight: bean jelly: cooling the seventh mixed material to room temperature by a fluidized bed, wherein the water content in the material is 2.5-4.0%;
step nine: mixing: adding phosphatidylserine, zeaxanthin and sialic acid according to a preset proportion, and uniformly mixing in a three-dimensional mixer to obtain the modified milk powder.
8. The method for preparing the modified milk powder for improving memory according to claim 6, wherein the dry mixing process comprises the following steps:
step A: preparation of medicinal and edible congeners: pulverizing medicinal and edible materials at a predetermined ratio by a pulverizer, placing the pulverized materials in a container, adding ethanol, soaking, extracting, mixing the ethanol extractive solutions, and concentrating until there is no alcohol smell; evaporating ethanol from the residue, soaking in water, decocting the soaking solution, filtering to remove the raw materials, and collecting the decoction; mixing the concentrated ethanol extractive solution and the decoction, spray drying, and sieving with 60-80 mesh sieve to obtain powder product;
and B: first-stage dry mixing, namely putting whole milk powder, medicinal and edible congeners, fish oil extracts, hydrolyzed yolk powder, dietary fibers, phosphatidylserine, sialic acid, zeaxanthin, compound vitamins and compound mineral substances in a predetermined proportion into a three-dimensional mixer, uniformly mixing to obtain a first material, and conveying the first material into a high-speed mixer through dense phase;
and C: and (2) performing second-stage dry mixing, namely putting the defatted milk powder, the whey powder, glucose syrup solid or lactose and the embedded vegetable oil powder into a high-speed mixer according to a preset proportion and uniformly mixing with the first material to obtain the modified milk powder.
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| CN110169454A (en) * | 2019-05-10 | 2019-08-27 | 上海育博营养食品有限公司 | A kind of children's formula milk for being conducive to protect eyes and help brain intelligence development |
| CN111513141A (en) * | 2020-05-11 | 2020-08-11 | 南通励成生物工程有限公司 | Solid beverage, preparation method thereof, tablet and granule |
| CN111513138A (en) * | 2020-05-26 | 2020-08-11 | 多加多乳业(天津)有限公司 | Sialic acid-containing formula milk powder for middle-aged and elderly people and preparation method thereof |
| CN111616221A (en) * | 2020-07-03 | 2020-09-04 | 北安宜品努卡乳业有限公司 | Milk powder for improving memory and relieving pressure and preparation method thereof |
| CN113424874A (en) * | 2021-07-14 | 2021-09-24 | 安徽天凯生物科技有限公司 | Formula of modified milk powder for improving cognitive function |
| CN116138316A (en) * | 2023-02-24 | 2023-05-23 | 西北农林科技大学 | Formula sheep milk powder for improving memory and preparation method thereof |
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