CN109965271A - A kind of children's brain growth tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of children's brain growth tailored version clinical nutrition formula and preparation method thereof Download PDF

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CN109965271A
CN109965271A CN201910267322.5A CN201910267322A CN109965271A CN 109965271 A CN109965271 A CN 109965271A CN 201910267322 A CN201910267322 A CN 201910267322A CN 109965271 A CN109965271 A CN 109965271A
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parts
powder
vitamin
children
brain
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/20—Fish extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of children's brain growth tailored version clinical nutrition formulas comprising following component and its parts by weight: 15-35 parts of protein, 2~15 parts of fat, 40~60 parts of carbohydrate, 8-12 parts of dietary fibers, 0.2-1.2 parts of macroelements, 0.01-0.05 parts of microelements, 0.001-0.02 parts of liposoluble vitamins, 0.008-0.4 parts of water soluble vitamins, 4~8 parts of diet essence, 0.1-4 parts of integration of drinking and medicinal herbs ingredients and 0.05-2 parts of new resource foods；The invention further relates to the preparation methods of above-mentioned clinical nutrition formula.Pass through the screening and proportion of said components, the present invention is according to the design of the physilogical characteristics of pregnant woman and children, on the basis of guaranteeing protein, fat, carbohydrate, dietary fiber, supplement the macroelement and microelement of many needed by human body, and add the specific nutrients such as the integration of drinking and medicinal herbs ingredient with brain tonic and intelligence development, stomach strengthening and digestion promoting, strengthen immunity and other effects, new resource food, so that the formula nutritional is balanced, effectively guarantee children's brain growth, guarantee pregnant woman and infant's grows up healthy and sound in all respects.

Description

A kind of children's brain growth tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food fields, and in particular to a kind of children's brain growth tailored version clinic battalion Support formula and preparation method thereof.
Background technique
People in embryonic stage, as soon as by the continuous division growth of fertilized eggs, for brain cell, can division growth to more than 100 hundred million A, this huge variation undoubtedly needs corresponding nutritional support.Newborn baby weight is about 370g~400g, only adult Be the 50% of Adult Human Brain weight when 25%, six months, arrived child it is one-year-old when brain weight reached 900g, be equivalent to Adult Human Brain weight 60%~70%.After having arrived child two years old, although the growth rate of brain weight slows down, but the certain nerve cells of intracerebral, such as small The intermediate nerve of type is former, exactly reaches maturity in this period of children.And the development of nerve cell axons and dendron, then may be used To establish more intensive desmachyme in brain and spinal cord.At last virgin 12 years old or so, his brain weight substantially with adult It is identical.It sees therefrom, whether brain development is normal, is determined by the quantity of cranial nerve cell and the density of desmachyme.Brain Nerve cell number is more, then the IQ of children is possible to higher, and the compactness extent of desmachyme is also to determine children from now on An important factor for intelligence height.From this, being the critical period of brain growth to 5 years old after children's birth, if child is in this period Subalimentation can make child's brain that irreversible permanent sexual dysfunction occur.In conclusion trophic factor, environmental factor, education Factor has a great impact to the development of the intelligence of children, and wherein trophic factor plays even more important effect.
The cerebral nervous system of fetus begins to develop on the the 5th, 6 week from pregnancy, until nerve channel healing completion in the 8th week, also It is to say, after embryo nidation, nerve cell just starts to break up, and then generates various nerve cells movements in conjunction with cynapse, is cherishing At pregnant 8th week, nerve channel just heals gradually, but the development of entire nervous system, can continue to that the pregnancy period terminates, or even go out to baby After life in 3 years, it can just reach 97% maturation.Nervous system is in all organs, and period of expansion longest is also most already to open simultaneously The organ of exhibition is originated, this is the well differentiated mankind and the maximum difference of other species.Due to currently on the market about brain The nutrition product type of development is intricate, such as Chinese patent CN101120784A discloses a kind of promotion fetus and infant The brain-care foods of brain development comprising 93~97 parts of linseed oil, 1~2 part of zinc citrate, 0.01~0.05 part of retinol, but The product is only studied single nutritional ingredient and is acted on the brain growth of children, and multiple nutritional components synergy is directed to brain growth Nutrition product it is relatively fewer, therefore research and develop it is a improve children's brain growth composite nutritional products be particularly important.
Summary of the invention
The purpose of the present invention is to overcome the defects in the prior art, provides a kind of tailored version for children's brain growth and faces Bed nutrient formulation, can meet the daily nutrition demand of pregnant woman and child, and children is helped to improve cerebral nervous system, improve children's note Recall power, promotes children's brain development.
To achieve the above object, the present invention adopts the following technical scheme:
The first purpose of the invention is to provide a kind of children's brain growth tailored version clinical nutrition formulas, which is characterized in that Including following component and its parts by weight: 15-35 parts of protein, 2-15 parts of fat, 40-60 parts of carbohydrate, 8-12 portions of meals Eat fiber, 0.2-1.2 parts of macroelements, 0.01-0.05 parts of microelements, 0.001-0.02 parts of liposoluble vitamins, 0.008- 0.4 part of water soluble vitamin, 4-8 parts of diet essence, 0.1-4 parts of integration of drinking and medicinal herbs ingredients and 0.05-2 parts of new resource foods.
In order to advanced optimize above-mentioned clinical nutrition formula, technical measures adopted by the present invention further include:
Further, the protein be selected from PURE WHEY, soybean protein isolate, Isin glue collagen peptide, whole milk powder, At least one of dried whole-egg, lactoferrin, colostrum, amino acid, protein peptides.
Wherein, the amino acid is selected from L-lysine-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, l-Isoleucine, L-Leu；The protein peptides are selected from hydrolyzed whey Albumen, soybean oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide At least one of.
Further, the protein packet hydrolyzing lactoalbumin powder, soybean protein isolate and taurine.
Further, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO knot At least one of structure rouge, DHA, EPA, ARA, phosphatide, the more specifically described fat includes safflower seed oil, walnut oil, peanut Oil, soybean oil, Ah's glycerol, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, cupu oil, palm oil, butter, cream, Lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil, DHA algal oil microcapsule powder, arachidonic acid oil microcapsule powder, phosphatide etc.； More preferably Purple Perilla Seed Oil, DHA algal oil microcapsule powder, arachidonic acid oil microcapsule powder, phosphatide.
Further, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least one of；More preferably maltodextrin.
Further, the dietary fiber includes inulin, konjaku flour, galactooligosaccharide, oligofructose, oligomeric different malt At least one of sugar, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；It is highly preferred that the dietary fiber includes water Soluble dietary fiber and insoluble diedairy fiber, the dietary fiber include oligofructose.
Further, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, citric acid At least one of sodium and magnesium gluconate；More preferably: calcium, wherein calcium is in calcium citrate, L- calcium lactate, calcium monohydrogen phosphate Any one or several form additions.
Further, the microelement is selected from ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, grape At least one of saccharic acid copper, chromium sulfate, manganese gluconate and sodium molybdate；More preferably: iron, zinc, wherein iron is with gluconic acid Ferrous form addition, wherein zinc is added in the form of zinc gluconate.
Further, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, dimension life Plain K1At least one of；More preferably: vitamin A, beta carotene, vitamin D3, vitamin E.
Further, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one of plain C, pantothenic acid, folic acid, niacin, choline, inositol, biotin；More preferably: vitamin B1, vitamin B2, dimension Raw element B6, vitamin B12, vitamin C, pantothenic acid, folic acid, niacin.
Further, the diet essence is selected from cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet flour, black rice flour, coixlacrymajobi powder, corn At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean At least one of powder, soy meal；The potato is mainly made of common yam rhizome powder；The Vegetable powder be selected from carrot meal, white radish powder, At least one of pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae is selected from mushroom powder, Kelp Powder At least one of with tremella powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch；The fishes and shrimps Class is selected from least one of salmon powder and cod meal；The poultry meat is selected from chicken meal, powdered beef, pork liver powder and pig kidney At least one of powder；The fruits in red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder extremely Few one kind.More preferably Kelp Powder.
Further, the integration of drinking and medicinal herbs ingredient include Radix Glycyrrhizae, fructus lycii, orange peel, Semen sesami nigrum, fructus alpiniae oxyphyllae, rhizoma polygonati, oyster, At least one of Poria cocos, Chinese yam, jujube, arillus longan；It more preferably include Radix Glycyrrhizae, fructus lycii, orange peel, Semen sesami nigrum, fructus alpiniae oxyphyllae, Huang Essence, oyster, Poria cocos, Chinese yam, specially 0.02~1 portion of Radix Glycyrrhizae, 0.02~1 portion of fructus lycii, 0.02~1 part of orange peel, 0.02~1 part Semen sesami nigrum, 0.02~1 part of fructus alpiniae oxyphyllae, 0.02~1 part of rhizoma polygonati, 0.02~1 portion of oyster, 0.02~1 part of Poria cocos, 0.02~1 part of mountain Medicine.
Further, it is few to be selected from first milk basic protein, hydrolysis yolk powder, γ-aminobutyric acid, shell for the new resource food Sugar, eucommia Bark male flower, bamboo-leaves flavones, casein phosphopeptide, fish oil, avenabeta glucosan, Oligomeric manna sugar, Rosa roxburghii Tratt, yeast β-Portugal At least one of glycan, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide；More preferably γ-aminobutyric acid, oligomeric sweet dew Sugar.
Further, above-mentioned nutrient formulation may also include nucleotide, be specially 5 ' monophosphate cytidines.
Further, children's brain growth tailored version clinic includes: maltodextrin, hydrolyzing lactoalbumin powder, purple perilla seed Oil, oligofructose, soybean protein isolate, resistant dextrin, DHA algal oil microcapsule powder, arachidonic acid oil microcapsule powder, Kelp Powder, Radix Glycyrrhizae, fructus lycii, orange peel, Semen sesami nigrum, fructus alpiniae oxyphyllae, rhizoma polygonati, oyster, Poria cocos, Chinese yam, Oligomeric manna sugar, γ-aminobutyric acid, calcium, Iron, zinc, vitamin A, beta carotene, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12、 Vitamin C, niacin, folic acid, pantothenic acid, taurine, phosphatide.
Further, above-mentioned nutrient formulation may also include enzymolysis pearl powder, black bone chicken powder, peony oil, choline and ganglioside Rouge.
Pearl contains the important substance for largely having magical effect to human body, a variety of amino acid and various trace elements, Indispensable amino acid starting material when synthesizing a variety of important good proteins in baby's growth course can be provided, fetal nerve is promoted System and cell development allow the brain of fetus to obtain innate advantage, while safeguarding the visual function of pregnant fetus, after enzymolysis processing Pearl powder is fully dissolved in water, and nutritional ingredient can be fully retained, but pearl calcium content is high, should add in right amount.Contain in Gallus domesticlus brisson There are DHA and EPA, the serial polyunsaturated fatty acid of the ω -3 such as DHA and EPA can promote brain development.It is unsaturated in peony oil Fatty acid is up to 80% or more, has good facilitation to infant's brain development, highly increases intelligence, and the dimension contained by it Raw element B3The metabolism of various tissues is maintained for infant, is promoted neoblastic growth and maturation, is baby's brain development Critical nutrients.Choline is the important source material for synthesizing acetylcholine, and acetylcholine is the important nerve for participating in memory and being formed Mediator, it can help to transmit information between nervous centralis, be one of necessary materials of intelligency activities such as human thinking, memory.Nerve Saving glycosides rouge helps nervous system development and information transmission, including neuron to generate dendroid, helps the efficiency for improving connection, newborn Youngster has 100,000,000,000 nerves not connected, and the nerve connection of high speed occurs to need a large amount of gangliosides, gangliosides The effect of be reinforce learning ability and maintain memory, promote brain growth.
Further, above-mentioned nutrient formulation may also include probiotic micro, and the probiotic micro is selected from intestines At least one of road fungal component bacteroides fragilis, Bifidobacterium, lactobacillus acidophilus, Lactobacillus rhamnosus.Probiotics is a kind of There is the active microorganism beneficial to host biobalance, biological barrier, biology to take oxygen, immunity effect, nutrition and substance, energy by force The functions such as the exchange between amount and information.Infantile period is the critical period that normal flora is established, and good flora foundation can be supported Imperial pathogenic microorganism invasion.The addition of probiotics can preferably protect enteron aisle, enhancing intestinal immunity, so that it is guaranteed that each nutrition The absorption of substance.
A second object of the present invention is to provide a kind of preparation sides of above-mentioned children's brain growth tailored version clinical nutrition formula Method method comprising following steps:
Step 1) prepares fat powder, liposoluble vitamin powder and water soluble vitamin powder using micro-capsule embedding techniques End；
Step 2) mentioned using crushing, alcohol extracting, water, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders；
Step 3) is smart by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, microelement, diet China and new resource food are prepared into the powder that partial size is 150~250 μm respectively, if necessary can be preparatory by above-mentioned raw materials It carries out baking processing；
Step 4) is by step 1)~3) powder of preparation sterilize after mixing it is spare；
The mixed powder of step 4) is prepared into nutrient powder, nutrition emulsion, capsule according to conventional technical means by step 5) At least one of agent, tablet, pill or oral solution；
Wherein, step 1) -3) sequence can mutually replace.
Finally, the present invention relates to a kind of products prepared by above-mentioned children's brain growth tailored version clinical nutrition formula, including Nutrient powder, nutrition emulsion, capsule, tablet, pill, oral solution etc..
In the above preparation method, wherein the raw material of the integration of drinking and medicinal herbs ingredient crushed, alcohol extracting concentration, water concentrate Contracting, and concentrate is subjected to spray drying, integration of drinking and medicinal herbs component powders are made；Wherein, the vitamin and fat are respectively by micro- Encapsulated processing is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows: using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, and 7~8 times of 30~40% second that weight is raw material weight are added Alcohol is impregnated, is extracted 3 times, is merged alcohol extract and is concentrated into no alcohol taste；After the raw medicine dregs of a decoction fling to ethyl alcohol, it is original that weight, which is added, 3~4 times of water of material weight is impregnated, and carries out 15~20min of decoction to soak, filtering removal raw material leaves and takes decoction Liquid；Alcohol extract and decoction liquor after merging concentration, and it is spray-dried, it is same finally to prepare medicine food with 60~80 meshes point Derived components powder.
Preferably, specific step is as follows for the microencapsulation processing of the vitamin: 1) using liposoluble vitamin as core Material selects sodium carboxymethylcellulose, gelatin, carragheen, xanthan gum, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One of powder, emulsifier, stabilizer are a variety of as wall material, and high-pressure homogeneous emulsification is spraying instantaneous dry, with 60~80 meshes Divide and prepares liposoluble vitamin powder；2) using water soluble vitamin as core material, sodium carboxymethylcellulose, gelatin, OK a karaoke club are selected Glue, xanthan gum, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum One of powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifier, stabilizer or a variety of works For wall material, it is uniformly mixed, it is spraying instantaneous dry, water soluble vitamin powder is prepared with 60~80 meshes point.
Preferably, the specific implementation step of the micro-capsule embedding techniques of the fat is as follows: by fat, emulsifier, wall material with Water mixed dissolution prepares emulsion；After above-mentioned emulsion is stirred, emulsifying homogeneous processing is carried out, is then done by spraying Dry, screening prepares fat powder, and fat powder is compared with conventional grease, and dispersibility, water solubility, emulsibility, inoxidizability are all It improves a lot；Wherein, the emulsifier be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), Sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin, monoglyceride, one in Tween 80 Kind is a variety of；The wall material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthan gum, Arabic gum, maltodextrin, rouge egg White, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean One of fiber, lactose, candy sugar powder, emulsifier, stabilizer are a variety of.
The present invention also provides a kind of preparation methods of above-mentioned children's brain growth tailored version clinical nutrition formula, are wet process work Skill includes the following steps:
Step 1) prepare the protein containing predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, Microelement, vitamin, diet essence, integration of drinking and medicinal herbs ingredient and new resource food raw material pressed in the water of predetermined amount It according to the physical behavior of raw material, successively adds according to sequencing, is stirred while addition, the mixing cream of raw material is made Liquid；
The mixed emulsion temperature that step 1) obtains is maintained at 40-50 DEG C by step 2), and adjustment homogenization pressure protects it always It holds between 10-18Mpa, emulsifying homogeneous is carried out to mixed emulsion, is then placed emulsion in evaporator, with preset technology Parameter is concentrated, and is sterilized at 85-88 DEG C, and concentrate is obtained；
The concentrate that step 2) obtains is spray-dried by step 3), is crossed 60~80 meshes, is prepared into powder；Using upper It states powder and is prepared at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution.
Using including Radix Glycyrrhizae, fructus lycii, orange peel, Semen sesami nigrum, fructus alpiniae oxyphyllae, rhizoma polygonati, oyster, Poria cocos, Chinese yam in the present invention；Its In, Radix Glycyrrhizae can be pleasant, promotes giving vent to for internal heat, helps the stabilization of mood, also there is certain relaxation effect, energy for spleen deficiency Enough help tonifying spleen；Fructus lycii can nourishing liver and kidney, benefiting shrewd head and blood-nourishing, enhance human immunity；Orange peel has conditioning digestion System enhances functions of intestines and stomach, and cholagogue is aid digestion, reduces for spleen deficiency diet, indigestion, receives to intestines caused by anti-acetylcholine Intestinal tube spasmodic contraction caused by contracting and antagonism pilocarpinum and barium chloride；Semen sesami nigrum contains there are many essential amino acid, It can increase the metabolic function of human body, also have effects that supplement brain intelligence, can promote brain development；The warm spleen of fructus alpiniae oxyphyllae energy stops It rushes down, appetite-stimulating and indigestion-relieving, enhancing children digestion, absorption function, balances interior environment, improve immune function；Rhizoma polygonati can supplementing the kidney to control the nocturnal, fill It is full of muscle, improves body immunity；Oyster taurine rich in has apparent hepatoprotective and cholagogic effects, and micro- containing enriching Secondary element and glycogen, and be conducive to promote the growth and development of fetus；Poria cocos can increase body's immunity, diuresis clearing damp, and ease constipation is led to Just, improve and digest and assimilate, transportation capabilities of the enhancing human body to food；Chinese yam can improve body's immunity, contain starch, albumen The various nutrients such as matter, mucilaginous substance, choline and lecithin rich in, help to improve the memory of the brain of people.
Compared with prior art, the invention has the following advantages:
In children's brain growth tailored version clinical nutrition formula of the present invention, perilla herb oil, n-3 PUFAs therein are added The building of film is participated in, the expression of gene is adjusted and effect that is anti-inflammatory and inhibiting Apoptosis is played by its metabolite Deng.The mechanism of action that n-3PUFAs influences brain function initially focuses mostly in the influence to brain membranous structure, PUFAs in phosphatide The mobility for changing changeable film, influences the transmitting of the neurotransmitters such as function, dopamine and the serotonergic of membrane receptor, adjusting film Binding protein, such as the activity of Na+/K+ dependence ATP enzyme.Change to provide a high-intensitive substance for brain by these The transduction environment of exchange and signal, plays an important role to the stability of cell.
Children's brain growth tailored version clinical nutrition formula supplement addition iron, zinc and vitamin B of the present invention1.Iron point Be distributed in entire brain tissue, but be unevenly distributed, the most abundant part of iron content is the core group of extrapyramidal system, as Basal ganglia, globus pallidus, The some regions of black substance, rubrum, followed by cerebellum and brain.The study found that main siderophore is oligodendroglia in brain tissue Cell, the cell major function are to participate in central nervous system myelin to be formed, and iron deficiency makes myelin formation be obstructed in brain growth.It is few prominent The variation of spongiocyte quantity will have a direct impact on utilization of the intracerebral neuron to iron, therefore think that oligodendroglia is brain tissue The adjusting body of iron balance.Zinc is the important composition ingredient of brain, the content of zinc highest in akrencephalon and cerebral cortex grey matter in brain.It lacks Vivo acid oxidation process increases when zinc, and histone synthesis is reduced, and growth and development is affected.Vitamin B1That is thiamine It plays an important role in body carbohydrate metabolism, if lacking thiamine, metabolic process will slack-off or complete interruption.
Children's brain growth tailored version clinical nutrition formula of the present invention also adds taurine, can promote brain cell The synthesis of DNA, RNA, the phosphatidylethanolamine content and brain cell for increasing film are to the utilization rate of protein, to promote brain cell The especially development of hippocampal cell structure and function；
γ-aminobutyric acid is added, the decarboxylic reaction of glutamic acid can be inhibited, is reacted with α-ketoglutaric acid and generates glutamic acid, Reduce blood ammonia, more glutamic acid and ammonia are combined into urea, excrete, and lower ammonia poison, improve hepatic and renal function.It can be improved The activity of glucose phosphate esterase keeps brain cell activity vigorous, promotes brain cell tissue metabolism, improves nervous function；
Phosphatide is added, total phosphorus lipid is related with the generation of cell membrane, and contains choline, is a kind of help human body manufacture brain The important composition of neural message transmitter (acetylcholine).Lecithin abundant is absorbed, the development of brains is helped, it is living to improve brain Dynamic efficiency.
The present invention is by selecting reasonable basal nutrient element, using the proportion of general equilibrium, while adding with brain tonic benefit The specific nutrients such as the integration of drinking and medicinal herbs ingredient of intelligence, stomach strengthening and digestion promoting, strengthen immunity and other effects, new resource food, and adjust it and match Than carrying out compatibility synergy with basal nutrient element, the daily required necessary nutritional ingredient of children's brain growth, and the nutrition are supplemented comprehensively Formula is easier the effect of being digested and assimilated by pregnant woman and child, giving full play to its each component, effectively guarantees children's brain growth institute Necessary nutrient, guarantee pregnant woman and infant's grows up healthy and sound in all respects.
Specific embodiment
The present invention provides a kind of children's brain growth tailored version clinical nutrition formula, including following component and its parts by weight: 15-35 parts of protein, 2-15 parts of fat, 40-60 parts of carbohydrate, 8-12 parts of dietary fibers, 0.2-1.2 parts of macroelements, 0.01-0.05 parts of microelements, 0.001-0.02 parts of liposoluble vitamins, 0.008-0.4 parts of water soluble vitamins, 4-8 portions of meals Eat essence, 0.1-4 parts of integration of drinking and medicinal herbs ingredients and 0.05-2 parts of new resource foods.
With reference to embodiment, the specific embodiment of the present invention is further described.Following embodiment is only used for more Add and clearly demonstrate technical solution of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
Children's brain growth tailored version clinical nutrition formula of the present invention includes maltodextrin 45g, hydrolyzing lactoalbumin Powder 20g, Purple Perilla Seed Oil 6g, oligofructose 6g, soybean protein isolate 6g, resistant dextrin 4g, DHA algae oil microcapsule powder 2g, peanut four Olefin(e) acid grease microcapsule powder 2g, Kelp Powder 6g, Radix Glycyrrhizae 0.4g, fructus lycii 0.4g, orange peel 0.6g, Semen sesami nigrum 0.6g, fructus alpiniae oxyphyllae 0.4g, Huang Smart 0.4g, oyster 0.6g, Poria cocos 0.6g, Chinese yam 0.6g, Oligomeric manna sugar 0.4g, γ-aminobutyric acid 0.4g, calcium 0.42g, iron 0.018g, zinc 0.016g, vitamin A 0.001g, beta carotene 0.002g, vitamin D30.0000015g, vitamin E 0.000016g, vitamin B10.002g, vitamin B20.002g, vitamin B60.002g, vitamin B12 0.000004g、 Vitamin C 0.18g, niacin 0.02g, folic acid 0.0006g, pantothenic acid 0.006g, taurine 0.12g, phosphatidase 0 .4g.
Embodiment 2
Children's brain growth tailored version clinical nutrition formula of the present invention includes maltodextrin 51.6g, hydrolyzed whey egg White powder 20g, Purple Perilla Seed Oil 3g, oligofructose 6g, soybean protein isolate 6g, resistant dextrin 4g, DHA algae oil microcapsule powder 0.2g, flower Raw tetraene acid lipid microcapsule powder 0.2g, Kelp Powder 6g, Radix Glycyrrhizae 0.4g, fructus lycii 0.4g, orange peel 0.6g, Semen sesami nigrum 0.6g, fructus alpiniae oxyphyllae 0.4g, rhizoma polygonati 0.4g, oyster 0.6g, Poria cocos 0.6g, Chinese yam 0.6g, Oligomeric manna sugar 0.4g, γ-aminobutyric acid 0.4g, calcium 0.42g, iron 0.018g, zinc 0.016g, vitamin A 0.001g, beta carotene 0.002g, vitamin D3 0.0000015g、 Vitamin E 0.000016g, vitamin B10.002g, vitamin B20.002g, vitamin B60.002g, vitamin B12 0.000004g, vitamin C 0.18g, niacin 0.02g, folic acid 0.0006g, pantothenic acid 0.006g, taurine 0.12g, phosphatide 0.4g。
Embodiment 3
Children's brain growth tailored version clinical nutrition formula of the present invention includes maltodextrin 51.6g, hydrolyzed whey egg White powder 20g, Purple Perilla Seed Oil 3g, oligofructose 6g, soybean protein isolate 6g, resistant dextrin 4g, DHA algae oil microcapsule powder 0.2g, flower Raw tetraene acid lipid microcapsule powder 0.2g, Kelp Powder 6g, Radix Glycyrrhizae 0.04g, fructus lycii 0.04g, orange peel 0.06g, Semen sesami nigrum 0.06g, benefit Intelligence benevolence 0.04g, rhizoma polygonati 0.04g, oyster 0.06g, Poria cocos 0.06g, Chinese yam 0.06g, Oligomeric manna sugar 0.4g, γ-aminobutyric acid 0.4g, calcium 0.42g, iron 0.018g, zinc 0.016g, vitamin A 0.001g, beta carotene 0.002g, vitamin D3 0.0000015g, vitamin E 0.000016g, vitamin B10.002g, vitamin B20.002g, vitamin B6 0.002g、 Vitamin B120.000004g, vitamin C 0.18g, niacin 0.02g, folic acid 0.0006g, pantothenic acid 0.006g, taurine 0.12g, phosphatidase 0 .4g.
Embodiment 4
Children's brain growth tailored version clinical nutrition formula of the present invention includes maltodextrin 51.6g, hydrolyzed whey egg White powder 20g, Purple Perilla Seed Oil 3g, oligofructose 6g, soybean protein isolate 6g, resistant dextrin 4g, DHA algae oil microcapsule powder 0.2g, flower Raw tetraene acid lipid microcapsule powder 0.2g, Kelp Powder 6g, Radix Glycyrrhizae 0.04g, fructus lycii 0.04g, orange peel 0.06g, Semen sesami nigrum 0.06g, benefit Intelligence benevolence 0.04g, rhizoma polygonati 0.04g, oyster 0.06g, Poria cocos 0.06g, Chinese yam 0.06g, Oligomeric manna sugar 0.04g, γ-aminobutyric acid 0:04g, calcium 0.42g, iron 0.018g, zinc 0.016g, vitamin A 0.001g, beta carotene 0.002g, vitamin D3 0.0000015g, vitamin E 0.000016g, vitamin B10.002g, vitamin B20.002g, vitamin B6 0.002g、 Vitamin B120.000004g, vitamin C 0.18g, niacin 0.02g, folic acid 0.0006g, pantothenic acid 0.006g, taurine 0.12g, phosphatidase 0 .4g.
Embodiment 5
A kind of children's brain growth tailored version clinical nutrition formula as described in Example 1 the preparation method is as follows:
1) powdered oil (powder fat) is prepared:
A) it prepares wall material aqueous solution: taking 8 grams of maltodextrin, 11 grams of whole-fat milk powder, dietary fiber 2 grams of (resistant dextrin), chrysanthemums 0.5 gram of powder, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, 0.2 gram of Arabic gum, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stir evenly (have ready conditions and heat while stirring to 60 DEG C, keep 30 minutes after be cooled to room temperature).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (Purple Perilla Seed Oil in 7.79 milliliters of greases monoglyceride 5.63 milliliters, 1.88 milliliters of DHA algal oil microcapsule powder, 1.88 milliliters of arachidonic acid oil microcapsule powder .38 milliliters of phosphatidase 0).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1 gram (total solid concentration be 0.2%) into after mixed solution, is settled to water 200 milliliters (total solid concentration be 25%), high speed dispersion 2 minutes under 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous 3 times (every time 5 minutes), homogeneous emulsion is made.
G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat)；
2) integration of drinking and medicinal herbs component powders are prepared: being crushed, will be crushed using raw material of the pulverizer to predetermined weight number Raw material be placed in container, crushed using raw material of the pulverizer to predetermined weight number, the raw material of crushing be placed in container In, be added weight be raw material weight 3~8 times of water, carry out immersion 3~4 hours, then to soak carry out decoction 30~ 60min, filtering removal raw material, leaves and takes decoction liquor, is spray-dried to decoction liquor, prepares integration of drinking and medicinal herbs with 60~80 meshes point Component powders；
3) prepare vitamin powder: using the liposoluble vitamin of predetermined weight number as core material, select carragheen, I Primary glue carries out 2 emulsifying homogeneous processing as wall material under high pressure, and the emulsifying homogeneous time is 10~15min, is then sprayed Mist is instantaneously dried, and prepares liposoluble vitamin powder with 60~80 meshes point；The water soluble vitamin of predetermined weight number is made For core material, selects maltodextrin, lipoprotein as wall material, be uniformly mixed, it is spraying instantaneous dry, water is prepared with 60~80 meshes point Soluble vitamin powder；
4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, microelement, diet essence with And new resource food is prepared into the powder that partial size is 150~250 μm respectively；(step 1) -4) sequence can mutually replace)
5) by step 1) -4) powder of preparation sequentially adds the mixing machines of cone-type mixer or other forms and is uniformly mixed system Formula mixture is obtained, it is spare after sterilization processing；
6) according to conventional technical means by the formula mixture in step 5) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral solution.
In step 6), optionally increase suitable food thickening agent, food additives and related dosage form auxiliary material. The food thickening agent is guar gum, in xanthan gum, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one, the food additives be at least one of Aspartame, edible essence fragrance, brown sugar；More preferable OK a karaoke club Glue, Arabic gum, guar gum, Aspartame, edible essence fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
It can be prepared into the classifications such as powdery, graininess, capsule shape, tablet shape, beverage according to the formula.
Verify embodiment 1
It chooses rat stochastic averagina and is assigned to experimental group, contrast groups and untreated fish group.
Experimental group 1: feed the feed of the nutrition powder prepared containing embodiment 1 (100g feed adds 5g nutrition powder)；
Experimental group 2: the nutrition powder prepared containing embodiment 1 and Lactobacillus rhamnosus, Bifidobacterium, enzymatic hydrolysis treasure are fed Pearl powder, black bone chicken powder, peony oil, choline and gangliosides feed (100g feed adds 5g nutrition powder), wherein relative to reality Apply the nutrition powder of the preparation of example 1, Lactobacillus rhamnosus, Bifidobacterium, enzymolysis pearl powder, black bone chicken powder, peony oil, choline and nerve The additive amount for saving glycosides rouge is 0.2g.
Contrast groups: feeding the feeds of the brain-care foods prepared containing CN101120784A embodiment 1, (100g feed adds 1.5g brain-care foods)；
Control group: normal diet is fed.
After nursing in 30 days, during nursing, the non-abnormal symptom of each rat and sign, also without death.Total food Utilization rate equal no significant difference compared with the control group；Each group content of hemoglobin, red blood cell count(RBC), white blood cell count(WBC) and classification are equal In the normal range, for every biochemical indicator in the normal range, each main organs gross anatomy detection does not find obvious disease Become.Demonstrating nutrient formulation of the present invention above will not influence normal growth and the development of rat, for that can eat safely Product.
Verify embodiment 2
100 progress clinical observations of children's atelencephalia patient are screened, and are randomly divided into two groups, experimental group 1, experimental group 2 and control group (every group of 50 people).Experimental group 1 use the resulting nutrition product of the present embodiment 1, experimental group 2 using embodiment 1 with And Lactobacillus rhamnosus, Bifidobacterium, enzymolysis pearl powder, black bone chicken powder, peony oil, choline and the resulting nutrient solution of gangliosides Product, the instructions of taking of experimental group 1 and 2: oral, 1 years old or less each 10ml, 1~6 years old each 20ml, 7~14 years old every time 30ml, 2 times a day.Control group uses drug (such as the cerebroganglion glycosides rouge injection, brain egg of conventional therapy children atelencephalia White hydrolysate, mouse nerve growth factor, oxiracetam injection etc.).
Curative effect situation criterion: effective: after being taken 30 days, clinical symptoms and sign disappear substantially；It improves: through taking After 30 days, clinical symptoms and sign are clearly better；Invalid: after being taken 30 days, clinical symptoms and sign slightly improvement or nothing change It is kind.It always effectively include effective and improvement.The results are shown in Table 1:
As seen from the above table, compared with control group (existing preparation), the present invention in by embodiment prepare nutrient formulation for Children atelencephalia patient has more excellent curative effect, this shows each component combination and compatibility in the nutrient formulation of the invention used It uses, produces synergistic beneficial effect.
As can be seen from the above embodiments, children's brain growth tailored version clinical nutrition compound basis pregnant woman of the present invention and small The physilogical characteristics of youngster design, and on the basis of guaranteeing protein, fat, carbohydrate, dietary fiber, supplement many human body institutes Need macroelement and microelement, and add have brain tonic and intelligence development, stomach strengthening and digestion promoting, strong immunity and other effects integration of drinking and medicinal herbs at Point, the specific nutrients such as new resource food effectively guarantee children's brain growth so that the formula nutritional is balanced, guarantee pregnant woman and Infant's grows up healthy and sound in all respects.
Specific embodiments of the present invention are described in detail above, but it is only used as example, the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, the equivalent modifications and replace that any couple of present invention carries out In generation, is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and repair Change, all should be contained within the scope of the invention.

Claims (10)

1. a kind of children's brain growth tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight: 15-35 parts of protein, 2-15 parts of fat, 40-60 parts of carbohydrate, 8-12 parts of dietary fibers, 0.2-1.2 parts of macroelements, 0.01-0.05 parts of microelements, 0.001-0.02 parts of liposoluble vitamins, 0.008-0.4 parts of water soluble vitamins, 4-8 portions of meals Eat essence, 0.1-4 parts of integration of drinking and medicinal herbs ingredients and 0.05-2 parts of new resource foods；
Wherein, the integration of drinking and medicinal herbs ingredient includes Radix Glycyrrhizae, fructus lycii, orange peel, Semen sesami nigrum, fructus alpiniae oxyphyllae, rhizoma polygonati, oyster, Poria cocos, mountain Medicine；The fat includes Purple Perilla Seed Oil, DHA algal oil microcapsule powder, arachidonic acid oil microcapsule powder, phosphatide；The new resources food Product include γ-aminobutyric acid, Oligomeric manna sugar.
2. a kind of children's brain growth tailored version clinical nutrition formula according to claim 1, which is characterized in that the carbon water Compound includes at least one of fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch.
3. a kind of children's brain growth tailored version clinical nutrition formula according to claim 1, which is characterized in that the albumen Matter includes amino acid, and the amino acid includes taurine, and the parts by weight of the taurine are 0.1~0.3 part.
4. a kind of children's brain growth tailored version clinical nutrition formula according to claim 1, which is characterized in that the medicine food It include 0.02-1 portions of Radix Glycyrrhizaes, 0.02-1 portions of fructus lyciis, 0.02-1 parts of orange peels, 0.02-1 portions of Semen sesami nigrums, 0.02-1 parts of benefits with derived components Intelligence benevolence, 0.02-1 part rhizoma polygonati, 0.02-1 portions of oysters, 0.02-1 parts of Poria cocos, 0.02-1 portions of Chinese yams.
5. a kind of children's brain growth tailored version clinical nutrition formula according to claim 1, which is characterized in that the phosphatide Parts by weight be 0.2~1 part.
6. a kind of children's brain growth tailored version clinical nutrition formula according to claim 1, which is characterized in that the nutrition Formula includes maltodextrin, hydrolyzing lactoalbumin powder, Purple Perilla Seed Oil, oligofructose, soybean protein isolate, resistant dextrin, DHA algal Oily microcapsule powder, arachidonic acid oil microcapsule powder, Kelp Powder, Radix Glycyrrhizae, fructus lycii, orange peel, Semen sesami nigrum, fructus alpiniae oxyphyllae, rhizoma polygonati, oyster, Poria cocos, Chinese yam, Oligomeric manna sugar, γ-aminobutyric acid, calcium, iron, zinc, vitamin A, beta carotene, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, folic acid, pantothenic acid, taurine, phosphatide.
7. a kind of children's brain growth tailored version clinical nutrition formula according to claim 6, which is characterized in that the nutrition Formula further includes enzymolysis pearl powder, black bone chicken powder, peony oil, choline and gangliosides.
8. a kind of children's brain growth tailored version clinical nutrition formula according to claim 6, which is characterized in that the nutrition Formula further includes probiotic micro, the probiotic micro be selected from commensal gut bacterium bacteroides fragilis, Bifidobacterium, At least one of lactobacillus acidophilus, Lactobacillus rhamnosus.
9. a kind of preparation method of such as children's brain growth tailored version clinical nutrition formula according to any one of claims 1 to 8, It is characterized by comprising the following steps:
The preparation of micro-capsule embedding techniques is respectively adopted simultaneously in the fat, liposoluble vitamin, water soluble vitamin of step (1) predetermined weight It crosses 60~80 meshes and powder is made；
The integration of drinking and medicinal herbs ingredient of step (2) predetermined weight is mentioned by crushing, alcohol extracting, water, is spray-dried and cross 60-80 mesh and is made Powder；
Remaining component of step (3) predetermined weight is prepared into the powder that partial size is 150~250 μm respectively；
Step (4) sterilizes powder prepared by step (1)~(3) spare after mixing；
Direct-edible pharmaceutical formulation is made in step (4) mixed powder by step (5)；
Wherein, step (1)~(3) sequence can be replaced mutually；The pharmaceutical formulation include nutrient powder, nutrition emulsion, capsule, Tablet, pill, oral solution.
10. the preparation method of children's brain growth tailored version clinical nutrition formula described according to claim 1~any one of 8, It is characterized by comprising the following steps:
Step 1) prepares the protein containing predetermined weight number and amino acid, fat, carbohydrate, dietary fiber, constant Element, microelement, vitamin, integration of drinking and medicinal herbs ingredient and new resource food raw material powder pressed in the water of predetermined amount It according to the physical behavior of raw material, successively adds according to sequencing, is stirred while addition, the mixing cream of raw material is made Liquid；
The mixed emulsion that step 2) obtains step 1) carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), and sieving is prepared into powder, and above-mentioned powder is prepared into At least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution.
CN201910267322.5A 2019-04-03 2019-04-03 A kind of children's brain growth tailored version clinical nutrition formula and preparation method thereof Withdrawn CN109965271A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113908258A (en) * 2021-11-11 2022-01-11 贵州贝斯生物科技有限公司 Preparation method and preparation device of ingestible ganglioside complementary peptide
CN115039876A (en) * 2022-05-20 2022-09-13 南通大学 A functional food for preventing and/or treating leukodystrophy
CN117397810A (en) * 2023-11-07 2024-01-16 广东金海康医学营养品股份有限公司 DHA algae oil special dietary drink and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113908258A (en) * 2021-11-11 2022-01-11 贵州贝斯生物科技有限公司 Preparation method and preparation device of ingestible ganglioside complementary peptide
CN113908258B (en) * 2021-11-11 2023-10-20 贵州贝斯生物科技有限公司 Preparation method and preparation device of orally taken ganglioside supplement peptide
CN115039876A (en) * 2022-05-20 2022-09-13 南通大学 A functional food for preventing and/or treating leukodystrophy
CN117397810A (en) * 2023-11-07 2024-01-16 广东金海康医学营养品股份有限公司 DHA algae oil special dietary drink and preparation method thereof

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Application publication date: 20190705