CN108013453A - Children's lactose intolerance tailored version clinical nutrition formula and preparation method thereof - Google Patents

Children's lactose intolerance tailored version clinical nutrition formula and preparation method thereof Download PDF

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CN108013453A
CN108013453A CN201711332713.8A CN201711332713A CN108013453A CN 108013453 A CN108013453 A CN 108013453A CN 201711332713 A CN201711332713 A CN 201711332713A CN 108013453 A CN108013453 A CN 108013453A
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parts
children
powder
lactose intolerance
clinical nutrition
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention provides a kind of children's lactose intolerance tailored version clinical nutrition formula, including following component and its parts by weight：15 22 parts of protein, 6 10 parts of fat, 43 58 parts of carbohydrate, 7 10 parts of dietary fibers, 0.01 0.15 parts of macroelements, 0.001 0.004 parts of trace elements, 0.001 0.003 parts of liposoluble vitamins, 0.01 0.03 parts of water soluble vitamins, 0.005 0.02 parts of meals elite, 0.0005 0.5 parts of integration of drinking and medicinal herbs components, 0.05 0.4 parts of natural plants compounds and 0.01 0.02 parts of new resource foods；The present invention also provides the preparation method for being related to two kinds of above-mentioned clinical nutrition formulas.The present invention alleviates the symptom of diarrhea of children lactose-intolerant person to provide comprehensive nutritional support, reinforcing calcium uptake with lactose intolerance children, nurses one's health enteron aisle, promotes enteron aisle to digest and assimilate, strengthens children's immunity of organisms.

Description

Children's lactose intolerance tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food field, more particularly to a kind of children's lactose intolerance tailored version to face Bed nutrient formulation and preparation method thereof.
Background technology
Lactose is a kind of disaccharide, its molecule is made of glucose and galactolipin, and lactose cannot directly be inhaled in human body Receipts could be absorbed, it is necessary to be decomposed under the action of lactase, is lacked the crowd of galantase after lactose is taken in, is not disappeared The lactose of change is directly entered large intestine, stimulates intestinal peristalsis to accelerate, causes the symptoms such as borborygmus, diarrhea to claim lactose intolerance.
Lactose intolerance crowd is after lactose is taken in, and since body lacks lactase in itself, the lactose of intake cannot It is digested and is absorbed into blood, but is trapped in enteron aisle.Enteric bacterial fermentation can produce a large amount of gases during reducing lactose.Make Into abdominal distension, passwind.Excessive lactose can also raise the osmotic pressure inside enteron aisle, prevent to cause diarrhea to the absorption of moisture；When The lactose of undecomposed absorption enter colon after, existing for enteron aisle bacterial fermentation become small molecule organic acid for example acetic acid, propionic acid, Butyric acid etc., and produce some gases such as methane, H2、CO2Deng.
The incidence of children's lactose intolerance is about 48%-58%.Most of baby with lactose intolerance symptom It is because the congenital shortage lactase of enteron aisle, causes lactose to be hydrolyzed in small enteral and be directly entered large intestine, in colon bacteria Under the action of produce sour gas, stimulate enteron aisle thus cause abdominal pain, abdominal distension and diarrhea, since children's large intestine Scavenging activity is compared with year Long youngster and adult are poor, so diarrhea becomes apparent from, either eating the baby of breast milk or milk can occur.Children's lactose intolerance Cardinal symptom shows as flatulence (for example have the hiccups, the tripe that rises, spit milk) and diarrhea.
Infant be child growth development critical period, it is necessary to general equilibrium supplement the nutrients, otherwise can cause physique A series of problems, such as developing slow, figure weakness, constipation, slow-witted reaction.If for example, remove treasured because of lactose intolerance symptom Dairy products in precious diet, can cause the calcium source deficiency needed for baby, influence bone and the dental health growth of baby；Lactose is not Symptom of diarrhea caused by tolerance, can cause baby's increased defecation, influence the stomach absorption function of baby.
Low lactose milk or lactose-free milk powder, soya-bean milk, rice product clinically are eaten for children's lactose intolerance at present, But relative to breast milk feeding, non-breast milk feeding lacks the energy matter, the strong material of antibacterial, life of baby's life growth development needs Auto-regulator, vitamin and trace element are managed, so as to influence the growth and development of baby, reduces the immunocompetence of baby.
Research shows that Chinese cassia tree, pueraria lobata, Rhizoma Atractylodis Macrocephalae, Poria cocos, malt, radix glycyrrhizae, corydalis tuber, rhizoma zingiberis, windproof, the banksia rose etc., which have, to be mended The effect of middle QI invigorating, strengthening the spleen and stomach, relieving diarrhea with astringents, analgesic hemostatic, muscle-growing and detumescence, can alleviate the symptoms such as abdominal pain, abdominal distension, diarrhea, Help to recover stomach absorption function.Such medicine diarrhea for caused by function of intestinal canal disorder has good recovery effects.
The content of the invention
The defects of it is an object of the invention to overcome in the prior art, there is provided a kind of children's lactose intolerance tailored version is clinical Nutrient formulation and preparation method thereof, it is according to the clinical nutrition feature of children's lactose intolerance, rightly to protein, carbon aquation Compound and fat mass ratio are adjusted, and are stopped feeding higher fatty acid and are difficult to the food digested, to mitigate stomach and intestine burden, by Gradually recover digestive function；Milk protein and lactose are not added, while is properly added lactalbumin and probiotics.Ensure children growth Nutrient necessary to development, strengthens calcium uptake, and can successfully manage the symptoms such as diarrhea caused by lactose intolerance, nurses one's health intestines Road, recovers the stomach absorption function of children as early as possible, improves the absorbability to nutrition, strengthens immunity of organisms, makes children extensive The multiple phase puts on weight and improves human body nutrition condition comprehensively as early as possible.
To achieve the above object, the present invention adopts the following technical scheme that：
First purpose of the present invention is to provide a kind of children's lactose intolerance tailored version clinical nutrition formula, including as follows Component and its parts by weight：15-22 parts of protein, 6-10 parts of fat, 43-58 parts of carbohydrate, 7-10 parts of dietary fibers, 0.7-1.1 parts of macroelements, 0.004-0.01 parts of trace elements, 0.001-0.003 parts of liposoluble vitamins, 0.01-0.03 parts Water soluble vitamin, 0.005-0.1 parts of meals elite, 0.0005-0.5 parts of integration of drinking and medicinal herbs components, 0.05-0.4 parts of natural plants Compound and 0.01-0.02 parts of new resource foods.
In order to further optimize above-mentioned clinical nutrition formula, the technical measures that the present invention is taken further include：
Preferably, the protein for lactalbumin, hydrolyzed milk protein, soybean protein isolate, hydrolysis Isin glue collagen, At least one of amino acid, protein peptides.
Wherein, the amino acid is selected from L-lysine-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, l-Isoleucine, L-Leu；The protein peptides are selected from soy oligosaccharides In peptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, casein calcium peptide, ovalbumin peptide At least one.
It is highly preferred that the protein includes lactalbumin, hydrolyzed milk protein, soybean protein isolate, hydrolysis collagen Albumen, taurine.
Preferably, the fat is saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, corn oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, sunflower oil, perilla herb oil, deep-sea fish Oil, cupu oil, palm oil, butter, cream, lard, lecithin, Purple Perilla Seed Oil etc.；More preferably walnut oil, olive oil, peanut Oil.
Preferably, the carbohydrate is included in fructose, rock sugar, maltodextrin, rock sugar, tapioca, resistant starch At least two；More preferably maltodextrin and rock sugar.
Preferably, the dietary fiber be inulin, it is konjaku flour, polyfructosan, soybean polyoses, cyclodextrin, resistant dextrin, big At least one of beans fiber；More preferably konjaku flour and polyfructosan.
Preferably, the macroelement for calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate and At least one of magnesium gluconate.
Preferably, the trace element is ferrous gluconate, ferrous pyrophosphate, potassium iodide, zinc gluconate, selenous acid At least one of sodium, copper gluconate.
Preferably, the liposoluble vitamin is vitamin A, beta carotene, vitamin D3, vitamin E, vitamin K1In At least one.
Preferably, the water soluble vitamin is vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, At least one of pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean At least one of powder, soy meal；The potato is mainly made of common yam rhizome powder；The Vegetable powder is selected from carrot meal, white radish powder, south At least one of melon powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae be selected from mushroom powder, Kelp Powder and At least one of white fungus powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch；The fish and shrimp Selected from least one of salmon powder, salmon powder, cod meal；The poultry meat is selected from chicken meal, powdered beef, pork liver powder At least one of with pig kidney powder；The fruits be selected from red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder, At least one of orange powder.
Preferably, the integration of drinking and medicinal herbs component be Chinese cassia tree, it is pueraria lobata, Rhizoma Atractylodis Macrocephalae, Poria cocos, malt, radix glycyrrhizae, corydalis tuber, rhizoma zingiberis, anti- At least one of wind, banksia rose；More preferably Chinese cassia tree, pueraria lobata, Poria cocos, malt, radix glycyrrhizae.
Preferably, the natural plants compound is l-cn, Glucosamine, oligofructose, lutein, plant steroid At least one of alcohol, lycopene, resveratrol, allicin；More preferably l-cn.
Preferably, the new resource food is γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, casein phosphorus Sour peptide, avenabeta glucosan, Oligomeric manna sugar, arachidonic acid oil, stachyose, Rosa roxburghii Tratt, yeast beta-dextran, xylo-oligosaccharide At least one of；More preferably chitosan oligosaccharide, yeast beta-dextran.
Active probiotic is further included in above-mentioned nutrient formulation；Active probiotic stimulates intestines to maintaining intestinal flora balance Road moves, and improves defecation, suppresses harmful bacteria propagation, reduces harmful substance generation, and treatment function of intestinal canal disorder has better effects, fits The crowd for closing lactose intolerance drinks, and peomotes the absorption of the nutriment such as protein, monose and calcium, magnesium, produces dimension life A large amount of benefit materials such as plain B races, immunoregulation effect, strengthens body immunity and resistance.
Micro qi-regulating Chinese medicine is further included in above-mentioned nutrient formulation；Qi-regulating Chinese medicine, which can effectively alleviate lactose intolerance, to be caused Symptom of diarrhea, strengthening the spleen and replenishing qi, stomach spleen nourishing the stomach, nurses one's health enteron aisle, and has no toxic side effect.
Preferably, the qi-regulating Chinese medicine for Chinese cassia tree, pueraria lobata, Rhizoma Atractylodis Macrocephalae, Poria cocos, malt, radix glycyrrhizae, corydalis tuber, rhizoma zingiberis, it is windproof, At least one of banksia rose.
Second object of the present invention is to provide a kind of by above-mentioned children's lactose intolerance tailored version clinical nutrition formula system The standby method into nutrient powder, it includes the following steps：
Step 1, fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques End, sterilization are spare；
Step 2, carried, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders, sterilization using crushing, alcohol extracting, water It is spare；
Step 3, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals essence China, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~300 μm respectively, and sterilization is spare；
Step 4, it is powder made from step 1~3 is canned in packaging bag or in pail pack after mixing；
Wherein, the order of step 1~3 can be replaced mutually.
The present invention also provides the side that a kind of above-mentioned children's lactose intolerance tailored version clinical nutrition formula is prepared into nutritional agents Method, it is wet processing, is included the following steps：
Step 1, fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques End, sterilization are spare；
Step 2, carried, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders, sterilization using crushing, alcohol extracting, water It is spare；
Step 3, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals essence China, natural plants compound and new resource food are prepared into the powder that particle diameter is 100~200 μm respectively, and sterilization is spare；
Step 4, powder made from step 1-3 is dissolved separately in a certain amount of water and aqueous solution is made；
Step 5, stirred after the aqueous solution that step 4 obtains is mixed at 55-65 DEG C, adjust ph to 6.5-6.8, mixed Close solution；
Step 6, under the protection of nitrogen, by mixed solution under 20-40MPa pressure homogeneous, after kept at 70-80 DEG C 20-30 seconds, postcooling was to 2-6 DEG C；
Wherein, the order of step 1~3 can be replaced mutually.
In above two preparation method, it is preferable that the specific implementation step of the fatty micro-capsule embedding techniques is as follows： A) wall material aqueous solution is prepared：Take maltodextrin, hydrolyzed milk protein powder, dietary fiber, inulin, PURE WHEY (lactose-free), Oligoisomaltose, 1 gram of soybean fiber, Arabic gum, candy sugar powder and water stir evenly；B) monoglyceride is dissolved in grease； C) Tween 80 is dissolved in wall material aqueous solution；D) liquid of blend step b) and step c), obtains mixed solution；E) addition is steady Agent agar is determined in mixed solution, constant volume, high speed dispersion under 20000r/min；F) under conditions of homogenization pressure is 25MPa, Matter 3 times, is made homogeneous emulsion；G) obtained homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, goes out wind-warm syndrome Spend for 80 DEG C；Collect and fat powder is made.
Preferably, the specific implementation step of the micro-capsule embedding techniques of the liposoluble vitamin is as follows：By predetermined weight part Several liposoluble vitamins selects carragheen, Arabic gum to carry out 2 emulsifying homogeneous under high pressure as wall material as core Processing, the emulsifying homogeneous time is 10~15min, then carries out instantaneous drying of spraying, and fat-soluble dimension is prepared with 60~80 mesh sieves point Raw element powder.
Preferably, the specific implementation step of the micro-capsule embedding techniques of the water soluble vitamin is as follows：By predetermined weight part Several water soluble vitamins is selected maltodextrin, lipoprotein to be used as wall material, is uniformly mixed as core, the instantaneous drying of spraying, with 60~80 mesh sieves point prepare water soluble vitamin powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, is added 3~8 times of the water that weight is raw material weight, is carried out immersion 3 ~4 it is small when, then carry out 30~60min of decoction to soak, filtering removes raw material, leaves and takes decoction liquor, decoction liquor is sprayed Mist is dried, and integration of drinking and medicinal herbs component powders are prepared with 60~80 mesh sieves point.
In the present invention using include peameal, mung bean flour, black bean powder, red bean powder, soy meal, spinach powder, broccoli powder, Apple powder, salmon powder, the meals elite of orange powder, without milk component, will not cause lactose intolerance symptom, and with abundant Nutrition, strengthen calcium uptake, supplement children lack due to a lack of calcium source caused by dairy products.
Using the new resource food for including chitosan oligosaccharide and yeast beta-dextran in the present invention, have after mentioned component compatibility synergy Have and promote intestinal beneficial flora growth, conditioning function of intestinal canal, the function of improving body immunity, promote nutrient absorption, especially Suitable for children lactose-intolerant person.
Chitosan oligosaccharide is that through special biological enzyme technology (chitosan is also had the report using chemical degradation, microwave degradation technology Road) obtained a kind of degree of polymerization of degrading oligosaccharide product, molecular weight≤3200Da between 2~20 are that water-soluble preferable, function is made With the high low molecular weight product of big, bioactivity, there is the unexistent higher solubility of chitosan, be dissolved in water entirely, easily given birth to Object such as absorbs at many unique functions, while the microbiota metabolic activity in adjustable animal intestinal tract, selectively activation, Breed beneficial bacterium growth, promote the human body profitable strain such as the absorption of calcium and mineral matter, propagation Bifidobacterium, lactic acid bacteria, improve machine Body immunocompetence；Adjusted suitable for the function of intestinal canal of children, promote the increment of active flora, to conditioning lactose-intolerant person's Symptom has to be acted on well.
Yeast beta-dextran is obtained by extraction from bread leaven matricyte wall, has the Tiny ecosystem of adjusting body digested road, Promote the propagation of internal beneficial bacterium, recover the stomach absorption function of baby as early as possible, while enhancing NK cells, macrophage can be stimulated thin The phagocytic activity of the immunocytes such as born of the same parents, stimulates release interleukin to strengthen body immunity.
The present invention uses above-mentioned technical proposal, compared with prior art, has the following technical effect that：
Children's lactose intolerance tailored version clinical nutrition formula of the present invention includes lactalbumin (lactose-free), hydrolysed milk 8 kinds supplemented needed for children must the protein general equilibriums such as albumen, soybean protein isolate, hydrolysis Isin glue collagen, taurine Amino acid is needed, without lactose constituent, the albumen demand of particular time children, low fat ratio, Hi CHO ratio can be supplemented Example, can prevent that fat intake is excessive and produces laxation, not only improve nutrition needed for supplement children, and easily inhaled for children intestinal digestion Receive；
Strengthen taurine, using the teaching of the invention it is possible to provide human body oxidation resistance, strengthens immunity of organisms；
Strengthen calcium, calcium is the main component for forming children's bone and tooth, can promote upgrowth and development of children, and it is close to improve bone Degree；
Strengthen iron, zinc, iron is the important element for forming hemoglobin, can prevent children anemia；Zinc is needed by human One of trace element, is the constituent of a variety of enzymes, it widely participates in various metabolic activities, is conducive to skin, bone and tooth The normal growth of tooth, promotes children's appetite, helps to strengthen children physique, so as to strengthen the body immunity of children；
A variety of fat-soluble type vitamin rational proportions, vitamin D can promote the absorption of calcium phosphorus, maintain calcium, phosphorus in blood Level, promotes the growth of children's bone and tooth；
Strengthen l-cn, l-cn category conditionity baby's required nutriment, energy is used as in baby by the use of fat Play an important role in the metabolism in source, it not only plays an important role in energy production and fat metabolic process, but also is tieing up Hold baby's life and promote infant development some physiology courses, as the ketogenesis, nitrogen metabolism etc. be respectively provided with it is certain Function, helps to strengthen the body immunity of children；
Yeast beta-dextran can effective adjusting body digested road Tiny ecosystem, promote the propagation of internal beneficial bacterium, it is extensive as early as possible The stomach absorption function of multiple baby, while the phagocytic activity of the immunocytes such as enhancing NK cells, macrophage can be stimulated, stimulate Interleukin is discharged to strengthen body immunity；
For active probiotic to maintaining intestinal flora balance, stimulation intestinal movement, improves defecation, suppresses harmful bacteria propagation, Harmful substance generation is reduced, treatment function of intestinal canal disorder there are better effects, is adapted to the crowd of lactose intolerance to drink, helps to promote Into the absorption of the nutriment such as protein, monose and calcium, magnesium, a large amount of benefit materials such as vitamin B complex are produced, immunological regulation is made With enhancing body immunity and resistance.
The present invention is by selecting rational basal nutrient element, using the proportioning of general equilibrium, while adds to have and promotes intestines The growth of road profitable strain, conditioning function of intestinal canal, improve body immunity, promote nutrient absorption function meals elite, new The specific nutrients such as resource food, natural plants compound, and adjust its proportioning and carry out compatibility synergy with basal nutrient element, comprehensively The necessary nutritional ingredient needed for children lactose-intolerant person is supplemented, and the nutrient formulation is free of lactose, easily by children's lactose not Intolerant patient digests and assimilates, the effect of giving full play to its each component, so as to making children put on weight as early as possible in convalescence and Improve human body nutrition condition comprehensively.
Embodiment
The present invention provides a kind of children's lactose intolerance tailored version clinical nutrition formula, including following component and its weight Number：15-22 parts of protein, 6-10 parts of fat, 43-58 parts of carbohydrate, 7-10 parts of dietary fibers, 0.7-1.1 parts of constants Element, 0.004-0.01 parts of trace elements, 0.001-0.003 parts of liposoluble vitamins, 0.01-0.03 parts of water soluble vitamins, 0.005-0.1 parts of meals elite, 0.0005-0.5 parts of integration of drinking and medicinal herbs components, 0.05-0.4 parts of natural plants compounds and 0.01-0.02 parts of new resource foods.
With reference to embodiment, the embodiment of the present invention is further described.Following embodiments are only used for more Add and clearly demonstrate technical scheme, and be not intended to limit the protection scope of the present invention and limit the scope of the invention.
Embodiment 1
Children's lactose intolerance tailored version clinical nutrition formula of the present invention include lactalbumin (lactose-free) 2.8g, Hydrolyzed milk protein 1.68g, soybean protein isolate 0.63g, hydrolysis Isin glue collagen 0.33g, taurine 0.02g；DHA0.02g、 Walnut oil 2.1g, olive oil 1.1g, peanut oil 3.1g；Maltodextrin 7.23g, rock sugar 1.1g；Konjaku flour 1.1g, polyfructosan 1.1g；Calcium 0.4g, phosphorus 0.229g, potassium 0.1g, sodium 0.145g, magnesium 0.147g in macroelement；Iron 0.005g, zinc in trace element 0.004g；Beta carotene 0.0008g, vitamin K10.0005g, vitamin D30.0002g, vitamin E 0.0017g；Vitamin B20.0013g, vitamin B60.0013g, vitamin C 0.01g, folic acid 0.0002g, nicotinic acid 0.0002g, biotin 0.0002g； Peameal 0.01g, mung bean flour 0.01g, black bean powder 0.01g, red bean powder 0.01g, soy meal 0.01g, spinach powder 0.01g, west are blue Pollen 0.01g, salmon powder 0.01g, apple powder 0.01g, orange powder 0.01g；Chinese cassia tree 0.03g, pueraria lobata 0.03g, Poria cocos 0.03g, malt 0.03g, radix glycyrrhizae 0.03g；L-cn 0.1g；Chitosan oligosaccharide 0.1g, yeast beta-dextran 0.1g；Active probiotic 0.1g。
Embodiment 2
Children's lactose intolerance tailored version clinical nutrition formula of the present invention include lactalbumin (lactose-free) 2.8g, Hydrolyzed milk protein 1.68g, soybean protein isolate 0.63g, hydrolysis Isin glue collagen 0.33g, taurine 0.02g；DHA0.02g、 Walnut oil 2.1g, olive oil 1.1g, peanut oil 3.1g；Maltodextrin 7.23g, rock sugar 1.1g；Konjaku flour 1.1g, polyfructosan 1.1g；Calcium 0.4g, phosphorus 0.229g, potassium 0.1g, sodium 0.145g, magnesium 0.147g in macroelement；Iron 0.005g, zinc in trace element 0.004g；Beta carotene 0.0008g, vitamin K1 0.0005g, vitamine D3 0.0002g, vitamin E 0.0017g；Dimension life Plain B20.0013g, vitamin B6 0.0013g, vitamin C 0.01g, folic acid 0.0002g, nicotinic acid 0.0002g, biotin 0.0002g；Peameal 0.01g, mung bean flour 0.01g, black bean powder 0.01g, red bean powder 0.01g, soy meal 0.01g, spinach powder 0.01g, broccoli powder 0.01g, salmon powder 0.01g, apple powder 0.01g, orange powder 0.01g；Chinese cassia tree 0.01g, pueraria lobata 0.01g, Poria cocos 0.01g, malt 0.01g, radix glycyrrhizae 0.01g；L-cn 0.1g；Chitosan oligosaccharide 0.1g, yeast beta-dextran 0.1g； Active probiotic 0.1g.
Embodiment 3
Children's lactose intolerance tailored version clinical nutrition formula of the present invention include lactalbumin (lactose-free) 0.8g, Hydrolyzed milk protein 0.08g, soybean protein isolate 3.23g, hydrolysis Isin glue collagen 0.33g, taurine 0.02g；DHA0.02g、 Walnut oil 2.1g, olive oil 1.1g, peanut oil 3.1g；Maltodextrin 7.23g, rock sugar 1.1g；Konjaku flour 1.1g, polyfructosan 1.1g；Calcium 0.4g, phosphorus 0.229g, potassium 0.1g, sodium 0.145g, magnesium 0.147g in macroelement；Iron 0.005g, zinc in trace element 0.004g；Beta carotene 0.0008g, vitamin K1 0.0005g, vitamine D3 0.0002g, vitamin E 0.0017g；Dimension life Plain B20.0013g, vitamin B6 0.0013g, vitamin C 0.01g, folic acid 0.0002g, nicotinic acid 0.0002g, biotin 0.0002g；Peameal 0.01g, mung bean flour 0.01g, black bean powder 0.01g, red bean powder 0.01g, soy meal 0.01g, spinach powder 0.01g, broccoli powder 0.01g, salmon powder 0.01g, apple powder 0.01g, orange powder 0.01g；Chinese cassia tree 0.01g, pueraria lobata 0.01g, Poria cocos 0.01g, malt 0.01g, radix glycyrrhizae 0.01g；L-cn 0.1g；Chitosan oligosaccharide 0.1g, yeast beta-dextran 0.1g； Active probiotic 0.1g.
Embodiment 4
The present embodiment verifies influence of the nutrient formulation of the present invention to children lactose-intolerant person.The present embodiment is adopted The pulvis prepared with the formula of embodiment 2 and following comparative examples：
Comparative example 1：Western medicine selects the medicines such as antibiotic, antidiarrheic, probiotics, while continues newborn class diet and feed Support.
Comparative example 2：Soybean protein isolate substitutes animal protein entirely, the pulvis that remaining component is prepared by the formula of embodiment 2；
Comparative example 3：Integration of drinking and medicinal herbs component is not added, the pulvis that remaining component is prepared by the formula of embodiment 2；
4 groups of experimental group of setting, every group of selection lactose intolerance children 30, by each 1g/kg of weight, daily 2-4 clothes With.All cases do not limit infusion.Acute person continuously observes 5 days, and chronic, unresolved continuous observation 10 days, records daily abdomen Rush down, generate heat, vomitting, the change situation of the symptom such as abdominal distension.Each group children carry out routine care.Therapy lasted is bright to each group symptom Untill aobvious improvement.Experimental result is as shown in table 1：
1 each group symptom average cure time of table compare (my god,)
Compared with 1 group of comparative example, * P ＜ 0.05；It is number of cases in bracket
As seen from the above table, 2 nutrient formulation of embodiment cannot shorten the healing time of children with acute diarrhea in the present invention, still The symptoms such as diarrhea, abdominal distension, vomiting can be alleviated rapidly；Comparative example 2 can shorten chronic, persisting diarrhea healing time, rapidly Alleviate the symptoms such as diarrhea, vomiting, abdominal distension.Comparative example 1-3 also has certain effect, but its effect be somewhat weaker than it is of the present invention Nutrient formulation.
By above-described embodiment, a kind of children's lactose intolerance tailored version clinical nutrition formula of the present invention and Its preparation method, its clinical nutrition feature not tolerated according to children, rightly matches somebody with somebody protein, carbohydrate and fat mass Than being adjusted, strengthen calcium uptake, while alleviate the symptom of diarrhea of children lactose-intolerant person, nurse one's health enteron aisle, promote enteron aisle Digest and assimilate, strengthen children's immunity of organisms.
The specific embodiment of the present invention is described in detail above, but it is intended only as example, it is of the invention and unlimited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and Substitute also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and Modification, all should be contained within the scope of the invention.

Claims (10)

1. a kind of children's lactose intolerance tailored version clinical nutrition formula, it is characterised in that including following component and its parts by weight Number：15-22 parts of protein, 6-10 parts of fat, 43-58 parts of carbohydrate, 7-10 parts of dietary fibers, 0.7-1.1 parts of constant members Element, 0.004-0.01 parts of trace elements, 0.001-0.003 parts of liposoluble vitamins, 0.01-0.03 parts of water soluble vitamins, 0.005-0.1 parts of meals elite, 0.0005-0.5 parts of integration of drinking and medicinal herbs components, 0.05-0.4 parts of natural plants compounds and 0.01-0.02 parts of new resource foods；
Wherein, the protein is lactalbumin (lactose-free), hydrolyzed milk protein, soybean protein isolate, hydrolysis collagen egg In vain, at least one of amino acid, protein peptides；
Wherein, it is fine to include inulin, konjaku flour, polyfructosan, soybean polyoses, cyclodextrin, resistant dextrin, soybean for the dietary fiber At least one of dimension.
2. a kind of children's lactose intolerance tailored version clinical nutrition formula according to claim 1, it is characterised in that described Protein includes lactalbumin (lactose-free), hydrolyzed milk protein, soybean protein isolate, hydrolysis Isin glue collagen, taurine.
3. a kind of children's lactose intolerance tailored version clinical nutrition formula according to claim 1, it is characterised in that described Carbohydrate includes at least two in fructose, rock sugar, maltodextrin, rock sugar, tapioca, resistant starch.
4. a kind of children's lactose intolerance tailored version clinical nutrition formula according to claim 1, it is characterised in that described Dietary fiber is konjaku flour and polyfructosan.
5. a kind of children's lactose intolerance tailored version clinical nutrition formula according to claim 1, it is characterised in that described Integration of drinking and medicinal herbs component is at least one in Chinese cassia tree, pueraria lobata, Rhizoma Atractylodis Macrocephalae, Poria cocos, malt, radix glycyrrhizae, corydalis tuber, rhizoma zingiberis, the windproof, banksia rose Kind.
6. a kind of children's lactose intolerance tailored version clinical nutrition formula according to claim 1, it is characterised in that described Natural plants compound is l-cn, Glucosamine, oligofructose, lutein, phytosterol, lycopene, white black false hellebore At least one of alcohol, allicin.
7. a kind of children's lactose intolerance tailored version clinical nutrition formula according to claim 1, it is characterised in that described New resource food is γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, casein phosphopeptide, avenabeta glucosan, low At least one of poly- mannose, arachidonic acid oil, stachyose, Rosa roxburghii Tratt, yeast beta-dextran, xylo-oligosaccharide.
8. a kind of children's lactose intolerance tailored version clinical nutrition formula according to claim 1, it is characterised in that described Nutrient formulation further includes active probiotic.
9. nutrition is prepared according to children's lactose intolerance tailored version clinical nutrition formula according to any one of claims 1 to 8 The method of powder, it is characterised in that it includes the following steps：
Step 1, fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques, killed Bacterium is spare；
Step 2, carried, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water, sterilization is spare；
Step 3, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~300 μm respectively, and sterilization is spare；
Step 4, it is powder made from step 1~3 is canned in packaging bag or in pail pack after mixing；
Wherein, the order of step 1~3 can be replaced mutually.
10. nutrition is prepared according to children's lactose intolerance tailored version clinical nutrition formula according to any one of claims 1 to 8 The method of agent, it is wet processing, it is characterised in that is included the following steps：
Step 1, fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques, killed Bacterium is spare；
Step 2, carried, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water, sterilization is spare；
Step 3, by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 100~200 μm respectively, and sterilization is spare；
Step 4, powder made from step 1-3 is dissolved separately in a certain amount of water and aqueous solution is made；
Step 5, stirred after the aqueous solution that step 4 obtains is mixed at 55-65 DEG C, adjust ph to 6.5-6.8, it is molten to obtain mixing Liquid；
Step 6, under the protection of nitrogen, by mixed solution under 20-40MPa pressure homogeneous, after keep 20- at 70-80 DEG C 30 seconds, postcooling was to 2-6 DEG C；
Wherein, the order of step 1~3 can be replaced mutually.
CN201711332713.8A 2017-12-13 2017-12-13 Children's lactose intolerance tailored version clinical nutrition formula and preparation method thereof Pending CN108013453A (en)

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