CN106579460A

CN106579460A - Special clinical nutrition formula for fracture and preparation method thereof

Info

Publication number: CN106579460A
Application number: CN201611206868.2A
Authority: CN
Inventors: 尤俊; 杨升平; 季敬东
Original assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Current assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Priority date: 2016-12-23
Filing date: 2016-12-23
Publication date: 2017-04-26

Abstract

The invention relates to a special clinical nutrition formula for fracture and a preparation method thereof. The special clinical nutrition formula for fracture is prepared from the following raw materials: protein, fat, carbohydrate, dietary fiber, macroelements, trace elements, fat-soluble vitamins, water-soluble vitamins, dietary essences, medicinal and edible components, natural plant compounds and new-resource foods; and the medicinal and edible components are at least one component selected from the following: peppermint, dried citrus reticulata peel, Chinese yams, long-stamen onion bulbs, Chinese wolfberry fruits, Chinese date fruits, longan flesh, and orange peel. The components are prepared into powder in advance, wherein the fat is prepared into fat powder by adopting a micro-capsule embedding technology and the dietary essences are prepared into powder by adopting a freeze-drying technology. The components are accordingly screened and proportioned, so that the special clinical nutrition formula disclosed by the invention is capable of providing complete basic energies and nutrients to the patients with fracture; moreover, components capable of increasing bone density, resisting infection, nourishing the blood and conditioning digestion are added, so that the special clinical nutrition formula is conducive to promoting bone healing, enhancing physical fitness and improving treatment effects on the patients with fracture.

Description

A kind of fracture tailored version clinical nutrition formula and preparation method thereof

Technical field

The present invention relates to special medicine purposes formula food field, and in particular to a kind of fracture tailored version clinical nutrition formula And preparation method thereof.

Background technology

Fracture is that the seriality of bone structure ruptures wholly or in part.Jing is appropriately processed in time, and most patients can recover former The function of coming, a few patients can leave different degrees of sequela.Often there is soft tissue injury, bleeds profusely, acutely in patient Pain or or even concurrently visceral injury etc..Fracture has a large amount of internal hemorrhages, and during absorption of hematoma, body temperature is slightly raised, but is not typically surpassed 38 DEG C are crossed, some there is also the possibility of infection.

Clinically, the fixation of bone is the key link of fractures.Early in 1958, interior fixed EASD just established The Therapeutic Principle of " blood supply, early functional exercise are protected in anatomical reduction, strong fixation ".Traditional operation is taken mainly at present It is fixed, partly fixed using Minimally Invasive Surgery.Through treatment, patient can obtain good therapeutic effect substantially.

The method of the promotion union of fracture commonly used after operative treatment at present is to take Chinese medicine preparation.Chinese patent CN103463380A discloses a kind of Chinese medicine preparation for treating fracture, and its raw material is the Radix Angelicae Dahuricae, Rhizoma Paridis, Herba Calami tetradactyli, Rhizoma Chuanxiong, wall scroll 16 kinds of Chinese herbal medicine such as grass, Herba Jasmini laurifolii, Nidus Vespae, silk cotton, can help the new bone of sequestrum absorption nutrition generation of fracturing, promote wound to heal Close, 96.7% is up to the total effective rate of fracture patient；Chinese patent CN102198272A disclose it is a kind of promote union of fracture, The pharmaceutical composition of injured nerve is repaired, its raw material is nerve growth factor, neurotrophic factor, vitamin B₁₂And antipyretic-antalgic Anti-inflammatory agent, which has a preferably healing facilitation to fracture patient, and trophic nerve unit and can promote repairing for injured nerve It is multiple.

But, prior art using Chinese medicine preparation treatment fracture method do not consider fracture and operative treatment to patient with The significant biophysical trauma for coming and nutrition equalization problem over the course for the treatment of.General fracture patient return to one's perfect health needs compared with Long process, this is easily caused patient and often worries that fracture recovers bad, produces a series of psychological problems, and further result in appetite side The impact in face.Reduce plus activity, enterokinesia slows down, absorb and be deteriorated, in turn result in Post operation tissue repair healing ability low Under, cause infection of incisional wound and poor healing, affect the effect for the treatment of.

It is and effect of the nutrition in vital movement is most important, particularly important to patient.In recent years, nutrition is controlled in disease Effect in treatment is taken seriously year by year, and nutritional intervention disease has become the common recognition of disease treatment.For this purpose, for fracture to patient Face how to promote knitting, prevent infection of incisional wound, lose blood, the key factor such as digestive problems, develop science, comprehensively clinical Nutrient formulation, to improving therapeutic effect, accelerates patient and recovers have important value and meaning.

The content of the invention

It is an object of the invention to overcome defect of the prior art, science, comprehensively is provided for fracture patient first Clinical nutrition formula, specifically, the present invention provides a kind of fracture tailored version clinical nutrition formula and preparation method thereof, the present invention Described nutrient formulation is to provide science, comprehensive professional Medical Degree for fracture patient.In the basis energy for providing needed by human body Amount and nutrient on the basis of, be also directed to patient it is common how to promote knitting, prevent infection of incisional wound, lose blood, digestive problems Etc. key factor, addition increase bone density, infection, enrich blood, nurse one's health digest integration of edible and medicinal herbs composition, natural plants compound and New resource food, contributes to knitting, the health invigorating of fracture patient, improves therapeutic effect.

For achieving the above object, the present invention is adopted the following technical scheme that：

On the one hand, the present invention provides a kind of wound, infection, operation and other stress state nutrient formulations, including following weight The component of amount number：35-45 part protein, 15-25 parts fat, 20-35 part carbohydrates, 5-10 part dietary fibers, 0.6- 1.2 parts of macroelements, 0.01-0.03 part trace element, 0.005-0.02 part fatsoluble vitamiies, 0.08-0.2 part water soluble vitamins Raw element, 0.1-6 part integration of edible and medicinal herbs compositions, 0.1-1 part natural plants compounds and 0.005-0.2 part new resource foods.

In order to further optimize above-mentioned technical proposal, the technical measures taken by the present invention also include：

Preferably, the protein is selected from lactalbumin powder, soybean protein isolate, whole milk powder, dried whole-egg, newborn ferrum egg In vain, at least one in cattle colostrumss, aminoacid, protein peptide；

Wherein, the aminoacid is selected from 1B-L-Glutamic Acid, mono- glutamic acid of L, mono- arginine of L, L-Tryptophan, L mono- At least one in glutamine, taurine, mono- L-Valine of L, L-Isoleucine, mono- leucines of L；The protein peptide is selected from Semen sojae atricolor Oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide, calcium caseinate At least one in peptide；Wherein, the preferred ocean fish oligopeptide powder of the protein peptide, Calcium peptide of casein.

Preferably, the fat includes satisfied fatty acid, polyunsaturated fatty acid, monounsaturated fatty acid, OPO structures At least one in fat, DHA, EPA, ARA, phospholipid, more specifically safflower oil, walnut oil, Oleum Arachidis hypogaeae semen, soybean oil, Ah Glycerol, olive oil, Oleum Camelliae, oil and fat of sacha inchi, olive oil, Oleum Cocois, perilla oil, bathypelagic fish oil, cupu oil, Petiolus Trachycarpi oil, Adeps Bovis seu Bubali, milk At least one in oil, Adeps Sus domestica, Medium-chain Triglycerides, lecithin.

Preferably, during the carbohydrate includes Fructose, crystal sugar, Lactose, maltodextrin, tapioca, resistant starch At least two.

Preferably, the dietary fiber comprising inulin, Rhizoma amorphophalli powder, oligomeric galactose, oligofructose, oligomeric isomaltose, At least one in soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber.

Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium hydrogen phosphate, potassium gluconate, sodium citrate With at least one in magnesium gluconate；It is highly preferred that the macroelement at least includes calcium citrate, L-calcium lactate and phosphoric acid Hydrogen calcium.

Preferably, the trace element is selected from Ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, glucose At least one in sour copper, chromic sulfate, manganese gluconate and sodium molybdate.

Preferably, the fatsoluble vitamin is selected from vitamin A, beta-carotene, Vitamin D3, Vitamin E, vitamin At least one in K1.

Preferably, the water soluble vitamins are selected from vitamin B1, vitamin B2, vitamin B6, Vitamin B12, dimension life At least one in plain C, pantothenic acid, Folic Acid, nicotinic acid, choline, inositol, biotin.

Preferably, the meals elite is selected from frumentum, beans, potato class, greengrocery, Homonemeae, nut-seed class, fish and shrimp At least one in class, poultry meat, fruits；Wherein, described frumentum is mainly by rice meal, millet powder, black rice flour, the heart of a lotus seed One kind or at least two compositions in rice flour, Semen Maydis powder, wheat germ powder, oatmeal, Fagopyrum esculentum Moench powder；The beans is mainly by Semen Pisi sativi One kind or at least two compositions in powder, Semen phaseoli radiati powder, black bean powder, red bean powder, Semen sojae atricolor powder；The potato class are mainly by common yam rhizome powder group Into；The Vegetable powder is mainly by Radix Dauci Sativae powder, white radish powder, Fructus Cucurbitae moschatae powder, Herba Spinaciae powder, tomato meal, broccoli powder, Fructus Momordicae charantiae powder, Fructus Cucumidis sativi One or more compositions in seed powder；The Homonemeae is mainly made up of one or more in mushroom powder and Tremella powder；It is described Nut-seed class is mainly Semen Nelumbinis powder；The fish and shrimp are mainly made up of one or more in salmon fish powder and cod meal； The poultry meat is mainly made up of one or more in Carnis Gallus domesticus powder, beef powder；The fruit is mainly by red date powder, Arillus Longan One or more compositions in powder, apple powder, cherry powder, Citrus powder, pear powder；The meals elite be more preferably oatmeal, At least one in cucumber seed powder.

Preferably, the integration of edible and medicinal herbs composition is selected from Herba Menthae, Exocarpium Citri Rubrum, Rhizoma Dioscoreae, Bulbus Allii Macrostemonis, Fructus Lycii, Fructus Jujubae, Arillus Longan, Pericarpium Citri tangerinae In at least one.

Preferably, the natural plants compound is selected from L-carnitine, glucosamine, oligofructose, phylloxanthin, plant At least one in sterol, lycopene, resveratrol, garlicin；The natural plants compound is more preferably L-carnitine.

Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, oligochitosan, eucommia Bark male flower, bamboo At least one in leaf flavone, phosphopeptide caseinate, avenabeta glucosan, yeast beta-dextran, leaf of Moringa, oligomeric xylose；Institute It is 1 to state new resource food and be more preferably newborn mineral salt and the ratio of weight and number of oligochitosan, the newborn mineral salt and oligochitosan:1.

Preferably, the high quality protein weight provided in the protein and aminoacid accounts for the 70% of gross protein weight More than.

Preferably, in the fat, the ratio of n-6 fatty acids and n-3 fatty acids is 3～4:1.

Preferably, in the integration of edible and medicinal herbs composition, the parts by weight of each component are as follows：Herba Menthae 0-0.2 parts, Exocarpium Citri Rubrum 0-0.2 Part, Rhizoma Dioscoreae 0-0.25 parts, Bulbus Allii Macrostemonis 0-0.2 parts, Fructus Lycii 0-0.2 parts, Fructus Jujubae 0-0.2 parts, Arillus Longan 0-0.2 parts, Pericarpium Citri tangerinae 0-0.2 Part.

On the other hand, the present invention relates to a kind of product prepared by fracture tailored version clinical nutrition formula, including nutritive powder, Nutrition emulsion, capsule, tablet, pill, oral liquid etc..

Finally, the present invention also provides a kind of method that the fracture tailored version clinical nutrition formula is prepared into nutritive powder, Which comprises the steps：By the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, micro Element, fatsoluble vitamin, water soluble vitamins, integration of edible and medicinal herbs composition, natural plants compound and new resource food difference The powdery that particle diameter is 100～300 μm is prepared into, by the powdery mix homogeneously, wound, infection is obtained, is performed the operation and other stress State nutritive powder, after sterilization processing, fill is in packaging bag or is placed directly within pail pack；Wherein, the fat is adopted Microcapsule embedding techniqueses make powder, and the meals elite makes powder using freeze drying process, the integration of edible and medicinal herbs into Divide powder is made by crushing, crossing 60-80 mesh sieves.

The present invention also provides a kind of method that the fracture tailored version clinical nutrition formula is prepared into nutrition emulsion, its bag Include following steps：

Step one, by the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, micro Element, fatsoluble vitamin, water soluble vitamins, integration of edible and medicinal herbs composition, natural plants compound and new resource food difference It is prepared into the powdery that particle diameter is 100～300 μm；Wherein, the fat makes powder, the meals using microcapsule embedding techniqueses Elite makes powder using freeze drying process, and the integration of edible and medicinal herbs composition makes powder by crushing, crossing 60-80 mesh sieves Shape；

Step 2, protein powder is dissolved in in a certain amount of water abundant aquation, obtains protein aqueous solution, then by carbon Hydrate powder, macroelement powder, trace element powder, water soluble vitamins powder are dissolved in protein aqueous solution, Gentle agitation is carried out, the aqueous phase solution being uniformly mixed；

Step 3, by the fat powder after microcapsule embedding treatment, fatsoluble vitamin powder, integration of edible and medicinal herbs component powders, Natural plants compound powder sequentially adds the aqueous phase solution of gained in step 2, and carries out strong agitation, addition emulsifying agent and Thickening agent, the concentrated emulsions being uniformly mixed；

Step 4, in the concentrated emulsions described in step 3 add scheduled volume water and stir, while removing skim-coat Foam, obtains Emulsion, then by Emulsion homogenizing under high pressure, in high temperature sterilize, is cooled to room temperature, and nutrition emulsion is obtained, and will Nutrition emulsion fill is in packaging bag.

In above two preparation method, the specific implementation step of microcapsule embedding techniqueses is as follows：By fat, emulsifying agent, wall Material prepares emulsion with water mixed dissolution；After by the stirring mixing of above-mentioned emulsion, emulsifying homogeneous process is carried out, is then sprayed It is dried, screening prepares powdered oil, and powdered oil is compared with conventional grease, its dispersibility, water solublity, emulsibility, non-oxidizability All improve a lot；

Wherein, the emulsifying agent is selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), Pyrusussuriensiss One or more in polysaccharide fatty acid ester (sorbitan acid), sucrose fatty acid ester (sucrose ester), lecithin；The wall material choosing From sodium carboxymethyl cellulose, gelatin, carrageenan, xanthan gum, arabic gum, guar gum, maltodextrin, lipoprotein, corn syrup In one or more.

In above two preparation method, the specific implementation step of freeze drying process is as follows：Raw material is cleaned, and to washing Raw material after net carries out predrying, then carries out pre-freeze to raw material so as to which pressure is evacuated to vacuum state and carries out sublimation drying, finally Dried raw material is carried out crushing 80 mesh sieves, the meals elite powder prepared using this technique farthest can be kept The color, smell and taste of raw material, go moisture removal thoroughly, and product can be preserved for a long time and be never degenerated.

In the present invention using include Herba Menthae, Exocarpium Citri Rubrum, Rhizoma Dioscoreae, Bulbus Allii Macrostemonis, Fructus Lycii, Fructus Jujubae, Arillus Longan, Pericarpium Citri tangerinae integration of edible and medicinal herbs into Point, by increasing capacitance it is possible to increase the bone density of patient, improves infection composition, while being enriched blood and being nursed one's health digestion.

Herba Menthae can cure cold to generate heat and have sore throat, headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella itching, the disease such as measles without adequate eruption, In addition to carbuncle, cellulitis, scabies, tinea, dermatitis rhus also effectively, which contains menthol, the material can fresh breath with various property of medicine, can delay Solution stomachache, gall-bladder problem such as spasm, also with antisepsis and sterilization, diuresis, resolving sputum, stomach invigorating and it is aid digestion the effects such as；

The chemical composition naringin of Exocarpium Citri Rubrum and Pericarpium Citri tangerinae, not only promoting bone growing but also the broken bone effect of suppression.Naringin is to rat reality The healing of the property tested bone injury has very strong facilitation, and acts on enhancing with Dose enhancement factors.The bone strengthening effect of naringin, both promoted Osteoblast activity, mechanism are probably the expression that naringin can improve bone morphogenic protein BMP-2-2；Bone can be suppressed brokenly thin again Born of the same parents, its mechanism are the RANKL signalling channels for suppressing osteoclast cell activation, cause differentiation of osteoclast, propagation to be obstructed, reduce bone and inhale Receive, and the bone dissolving of polymethacrylates induction can be suppressed.In terms of bone resorption is reduced, naringin has suppression tartaric acid acid Acid phosphatase activity, reduces RANKL expression, suppresses osteoclast activity, reduces the effect that the loss and bone density of bone amount decline； In terms of skeletonization, naringin mainly improves osteopontin, the expression of osteoprotegerin, increases Bone Gla protein, promotes human marrow-interstitial The ability of stem cell HBMSCs cells propagation and Osteoblast Differentiation.

Rhizoma Dioscoreae enters lung, spleen, kidney channel, spleen reinforcing；Foster lung；Reinforce the kidney；Beneficial essence.Main diarrhea due to hypofunction of the spleen；Lack of appetite edema；Cough and asthma due to lung deficiency；Disappear Yearningly；Kidney deficiency frequent micturition；Carbuncle is controlled in external；Scrofula.Breath with cough for spleen eating less, incessant chronic diarrhea, the deficiency of the lung, frequent micturition, deficiency-heat are quenched one's thirst；

Bulbus Allii Macrostemonis return lung, stomach, large intestine channel, effect are qi-regulating the chest stuffiness relieving, activating YANG and eliminating stagnation.The thorough back of the body of main obstruction of qi in the chest and cardialgia；Chest gastral cavity ruffian；Cough Breathe heavily abundant expectoration；Epigastric pain；Let out weight after dysentery；Leucorrhea；Furuncle carbuncle.For thoracic obstruction pain, phlegm retention cough with asthma, weight after dysentery is let out；

Fructus Lycii enters liver and kidney channel, nourishing the liver；Nourishing kidney；Lung moistening.Main caused by liver and kidney deficiency；Have a dizzy spell；Visual one is clear；Soreness of the waist and knees；Sun The expensive essence of flaccidity；Cough due to consumptive disease；Quench one's thirst taking fluids profusely.For consumption consumptive loss, soreness of waist and knee joint, vertigo and tinnitus, Heat Diabetes, blood deficiency and yellow complexion, mesh Dusk is not clear；

Fructus Jujubae enters spleen, stomach, tonifying the spleen and stomach；Replenishing QI and blood；Tranquilizing mind；Battalion is adjusted to defend；And the property of medicine.Main weakness of the spleen and stomach；Insufficiency of vital energy and blood； Anorexia and loose stool；Fatigue and weakness；Palpitation and insomnia.For diarrhea due to hypofunction of the spleen, cardiopalmus, insomnia, night sweat, thrombocytopenic purpura；

Arillus Longan GUIXIN；Kidney；Liver；Spleen channel, reinforcing the heart spleen；Replenishing QI and blood；Tranquilizing mind.Main deficiency of both the heart and spleen；Caused by insufficiency of vital energy and blood Palpitation with fear；Palpitation with a distress feeling；Insomnia；It is forgetful；Blood deficiency and yellow complexion；There is Jing uncomfortable；Metrorrhagia.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood It is empty sallow.

Compared with prior art, the invention has the advantages that：

(1) L-calcium lactate in addition macroelement, calcium citrate, calcium hydrogen phosphate, while adding in new resource food Newborn mineral salt, newborn mineral salt be with milk surum as raw material, Jing remove the composition milk basic protein such as isolating protein, Lactose and made by profit In the supplementary of absorption of human body, containing more mineral, mainly calcium and phosphorus, above-mentioned four kinds of material compositions are combined calcium source, Ensure the calcium content needed for fracture repair process, and promote the absorption of calcium

(2) add the Calcium peptide of casein in protein peptide as calcium absorption enhancer, promote the absorption of calcium constituent, in food Calcium becomes solubility calcium under gastric juice (hydrochloric acid) effect, but during in neutrality into the small intestinal of weakly alkaline environment, wherein having one Part will be combined into insoluble calcium phosphate precipitation with phosphoric acid and cannot be absorbed by human body, when there is Calcium peptide of casein (CCP), when, may be prevented from generating calcium phosphate precipitation, make calcium ion be constantly in dissolved state, so that fracture patient is improved to calcium Absorbance, promote its wound healing.

(3) add the oligochitosan in new resource food, which has the absorption for improving immunity, promoting calcium and mineral.

(4) present invention addition integration of edible and medicinal herbs composition, its each component complement each other, and determined curative effect, Exocarpium Citri Rubrum, Pericarpium Citri tangerinae can increase bone Density, not only promoting bone growing but also the broken bone effect of suppression；Herba Menthae, Bulbus Allii Macrostemonis contain infection composition；Fructus Lycii, Fructus Jujubae, Arillus Longan have Preferable nourishing blood function；Pericarpium Citri tangerinae, Herba Menthae can nurse one's health digestive function well, and above-mentioned compatibility can effectively facilitate knitting, prevent from cutting Mouthfeel contaminates, loses blood, and nurses one's health digestion, promotes the absorption of nutrient substance；

(5) present invention prepares powdered oil using microcapsule embedding techniqueses so that powdered oil has preferable mobility, easily In mixing homogeneously with other powdered components；And using after microcapsule embedding techniqueses, oils and fatss are embedded in wall material, so as to avoid with The contact of air to strengthen non-oxidizability, so as to the maximum effect of health oils and fatss can be played；

(6) present invention prepares meals elite powder using freeze drying process so that the product quality of preparation is loose, adds water The primary characteristic of recovering dietary fiber is dissolved rapidly can；Which is prepared under vacuum state, time of contact short with oxygen, dried Water content of materials is relatively low, is conducive to the long term storage of product；The color of meals elite is preserved to greatest extent, such as vegetable Natural pigment keeps constant, and the loss of various aromatic substances may decrease to bottom line, and this easily increases the appetite of fracture patient, protects Demonstrate,prove its nutritional need during curing；

(7) raw material of wound of the present invention, infection, operation and other stress state nutrient formulations is in preparation process The previously prepared powder into 100～300 μm, this is caused when finished product is prepared, and each nutrition composition being capable of mix homogeneously, it is ensured that single The content of each nutrition composition in the volume of position is essentially identical, while when liquid type preparation is prepared, each nutrition composition fully can divide Dissipate and be completely dissolved into solvent, in preventing liquid, solid precipitation occur, effect of finished product product has been effectively ensured.

Specific embodiment

The present invention provide it is a kind of for fracture patient with increase bone density, infection, enrich blood, nurse one's health digestive function Fracture tailored version clinical nutrition formula, including the component of following parts by weight：Including the component of following parts by weight：20-35 parts Protein, 5-15 parts fat, 28-40 part carbohydrates, 3-9 part dietary fibers, 0.5-1.5 part macroelements, 0.01-0.03 Part trace element, 0.005-0.02 part fatsoluble vitamiies, 0.08-0.2 part water soluble vitamins, 0.1-1 part meals elite, 0.2-8 part integration of edible and medicinal herbs compositions, 0.5-1.2 part natural plants compounds and 0.05-0.8 part new resource foods.

With reference to embodiment, the specific embodiment of the present invention is further described.Following examples are only used for more Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.

Embodiment 1

Fracture tailored version clinical nutrition formula of the present invention includes lactalbumin powder 10.3g, soybean protein isolate 4.33g, whole milk powder 12g, dried whole-egg 0.33g, cattle colostrumss 0.16g, taurine 0.11g, ocean fish oligopeptide powder 0.266g, cheese Calcium peptide 0.05g；Olive oil 2.77g, soybean oil 4.48g, Oleum Cocois 2.77g, perilla oil 0.64g, Medium-chain Triglycerides 0.213g；Maltodextrin 21.46g, resistant starch 13.33g；The dietary fiber selected from inulin, Rhizoma amorphophalli powder, oligomeric galactose, At least one in oligofructose, oligomeric isomaltose, soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber, its gross mass For 5.99g, wherein water soluble dietary fiber 4.83g, fat-soluble dietary fiber 1.16g；Calcium 0.7g in macroelement, phosphorus 0.21g, Potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；In fatsoluble vitamin Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D₃0.000001g, Vitamin E 0.009g；Water soluble vitamin Vitamin B in raw element₁0.001g, vitamin B₂0.001g, vitamin B 60.001g, vitamin B₁₂0.000002g, dimension life Plain C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.333g, cucumber seed powder 0.4g；Medicine Food with Herba Menthae 0.5g in derived components, Exocarpium Citri Rubrum 0.5g, Rhizoma Dioscoreae 0.5g, Bulbus Allii Macrostemonis 0.5g, Fructus Lycii 0.5g, Fructus Jujubae 0.5g, Arillus Longan 0.5g, Pericarpium Citri tangerinae 0.5g；L-carnitine 1g in natural plants compound；Newborn mineral salt 0.3g, oligochitosan 0.3g in new resource food.

Embodiment 2

Fracture tailored version clinical nutrition formula of the present invention includes lactalbumin powder 10.3g, soybean protein isolate 4.33g, whole milk powder 12g, dried whole-egg 0.33g, cattle colostrumss 0.16g, taurine 0.11g, ocean fish oligopeptide powder 0.266g, cheese Calcium peptide 0.05g；Olive oil 2.77g, soybean oil 4.48g, Oleum Cocois 2.77g, perilla oil 0.64g, Medium-chain Triglycerides 0.213g；Maltodextrin 21.46g, resistant starch 13.33g；The dietary fiber selected from inulin, Rhizoma amorphophalli powder, oligomeric galactose, At least one in oligofructose, oligomeric isomaltose, soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber, its gross mass For 5.99g, water soluble dietary fiber 4.83g, fat-soluble dietary fiber 1.16g wherein in dietary fiber；Calcium in macroelement 0.6g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element； Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in fatsoluble vitamin₃0.000001g, Vitamin E 0.009g；Vitamin B in water soluble vitamins₁0.001g, vitamin B₂0.001g, vitamin B 60.001g, vitamin B₁₂ 0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.333g, it is yellow Squash seed meal 0.2g；Herba Menthae 0.166g, Exocarpium Citri Rubrum 0.166g, Rhizoma Dioscoreae 0.227g, Bulbus Allii Macrostemonis 0.166g, Fructus Lycii in integration of edible and medicinal herbs composition 0.166g, Fructus Jujubae 0.166g, Arillus Longan 0.166g, Pericarpium Citri tangerinae 0.166g；L-carnitine 0.633g in natural plants compound；It is new to provide Newborn mineral salt 0.3g, oligochitosan 0.3g in the food of source.

Embodiment 3

Fracture tailored version clinical nutrition formula of the present invention includes lactalbumin powder 10.3g, soybean protein isolate 4.33g, whole milk powder 12g, dried whole-egg 0.33g, cattle colostrumss 0.16g, taurine 0.11g, ocean fish oligopeptide powder 0.266g, cheese Calcium peptide 0.033g；Olive oil 2.77g, soybean oil 4.48g, Oleum Cocois 2.77g, perilla oil 0.64g, Medium-chain Triglycerides 0.213g；Maltodextrin 21.46g, resistant starch 13.33g；The dietary fiber selected from inulin, Rhizoma amorphophalli powder, oligomeric galactose, At least one in oligofructose, oligomeric isomaltose, soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber, its gross mass For 5.99g, water soluble dietary fiber 4.83g, fat-soluble dietary fiber 1.16g wherein in dietary fiber；Calcium in macroelement 0.6g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element； Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in fatsoluble vitamin₃0.000001g, Vitamin E 0.009g；Vitamin B in water soluble vitamins₁0.001g, vitamin B₂0.001g, vitamin B 60.001g, vitamin B₁₂ 0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.333g, it is yellow Squash seed meal 0.2g；Herba Menthae 0.166g, Exocarpium Citri Rubrum 0.166g, Rhizoma Dioscoreae 0.227g, Bulbus Allii Macrostemonis 0.166g, Fructus Lycii in integration of edible and medicinal herbs composition 0.166g, Fructus Jujubae 0.166g, Arillus Longan 0.166g, Pericarpium Citri tangerinae 0.166g；L-carnitine 0.633g in natural plants compound；It is new to provide Newborn mineral salt 0.167g, oligochitosan 0.167g in the food of source.

Embodiment 4

Fracture tailored version clinical nutrition formula of the present invention includes lactalbumin powder 10.3g, soybean protein isolate 4.33g, whole milk powder 12g, dried whole-egg 0.33g, cattle colostrumss 0.16g, taurine 0.11g, ocean fish oligopeptide powder 0.266g, cheese Calcium peptide 0.033g；Olive oil 2.77g, soybean oil 4.48g, Oleum Cocois 2.77g, perilla oil 0.64g, Medium-chain Triglycerides 0.213g；Maltodextrin 21.46g, resistant starch 13.33g；The dietary fiber selected from inulin, Rhizoma amorphophalli powder, oligomeric galactose, At least one in oligofructose, oligomeric isomaltose, soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber, its gross mass For 5.99g, water soluble dietary fiber 4.83g, fat-soluble dietary fiber 1.16g wherein in dietary fiber；Calcium in macroelement 0.3g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element； Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in fatsoluble vitamin₃0.000001g, Vitamin E 0.009g；Vitamin B in water soluble vitamins₁0.001g, vitamin B₂0.001g, vitamin B 60.001g, vitamin B₁₂ 0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.333g, it is yellow Squash seed meal 0.1g；Herba Menthae 0.166g, Exocarpium Citri Rubrum 0.166g, Rhizoma Dioscoreae 0.227g, Bulbus Allii Macrostemonis 0.166g, Fructus Lycii in integration of edible and medicinal herbs composition 0.166g, Fructus Jujubae 0.166g, Arillus Longan 0.166g, Pericarpium Citri tangerinae 0.166g；L-carnitine 0.633g in natural plants compound；It is new to provide Newborn mineral salt 0.1g, oligochitosan 0.1g in the food of source.

Embodiment 5

Fracture tailored version clinical nutrition formula of the present invention includes lactalbumin powder 10.3g, soybean protein isolate 4.33g, whole milk powder 12g, dried whole-egg 0.33g, cattle colostrumss 0.16g, taurine 0.11g, ocean fish oligopeptide powder 0.266g, cheese Calcium peptide 0.02g；Olive oil 2.77g, soybean oil 4.48g, Oleum Cocois 2.77g, perilla oil 0.64g, Medium-chain Triglycerides 0.213g；Maltodextrin 21.46g, resistant starch 13.33g；The dietary fiber selected from inulin, Rhizoma amorphophalli powder, oligomeric galactose, At least one in oligofructose, oligomeric isomaltose, soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber, its gross mass For 5.99g, water soluble dietary fiber 4.83g, fat-soluble dietary fiber 1.16g wherein in dietary fiber；Calcium in macroelement 0.3g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element； Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in fatsoluble vitamin₃0.000001g, Vitamin E 0.009g；Vitamin B in water soluble vitamins₁0.001g, vitamin B₂0.001g, vitamin B 60.001g, vitamin B₁₂ 0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.333g, it is yellow Squash seed meal 0.1g；Herba Menthae 0.1g, Exocarpium Citri Rubrum 0.1g, Rhizoma Dioscoreae 0.1g, Bulbus Allii Macrostemonis 0.1g, Fructus Lycii 0.1g, Fructus Jujubae in integration of edible and medicinal herbs composition 0.1g, Arillus Longan 0.1g, Pericarpium Citri tangerinae 0.1g；L-carnitine 0.633g in natural plants compound；Newborn mineral salt in new resource food 0.1g, oligochitosan 0.1g.

Embodiment 6

Fracture tailored version clinical nutrition formula of the present invention includes lactalbumin powder 10.3g, soybean protein isolate 4.33g, whole milk powder 12g, dried whole-egg 0.33g, cattle colostrumss 0.16g, taurine 0.11g, ocean fish oligopeptide powder 0.266g, cheese Calcium peptide 0.02g；Olive oil 2.77g, soybean oil 4.48g, Oleum Cocois 2.77g, perilla oil 0.64g, Medium-chain Triglycerides 0.213g；Maltodextrin 21.46g, resistant starch 13.33g；The dietary fiber selected from inulin, Rhizoma amorphophalli powder, oligomeric galactose, At least one in oligofructose, oligomeric isomaltose, soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber, its gross mass For 5.99g, water soluble dietary fiber 4.83g, fat-soluble dietary fiber 1.16g wherein in dietary fiber；Calcium in macroelement 0.3g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element； Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D in fatsoluble vitamin₃0.000001g, Vitamin E 0.009g；Vitamin B in water soluble vitamins₁0.001g, vitamin B₂0.001g, vitamin B 60.001g, vitamin B₁₂ 0.000002g, vitamin C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.333g；Medicine Food with Herba Menthae 0.1g in derived components, Exocarpium Citri Rubrum 0.1g, Rhizoma Dioscoreae 0.1g, Bulbus Allii Macrostemonis 0.1g, Fructus Lycii 0.1g, Fructus Jujubae 0.1g, Arillus Longan 0.1g, Pericarpium Citri tangerinae 0.1g；L-carnitine 0.633g in natural plants compound；Newborn mineral salt 0.1g, oligochitosan 0.1g in new resource food.

Embodiment 7

Fracture tailored version clinical nutrition formula of the present invention includes lactalbumin powder 10.3g, soybean protein isolate 4.33g, whole milk powder 12g, dried whole-egg 0.33g, cattle colostrumss 0.16g, taurine 0.11g, ocean fish oligopeptide powder 0.266g, cheese Calcium peptide 0.01gg；Olive oil 2.77g, soybean oil 4.48g, Oleum Cocois 2.77g, perilla oil 0.64g, Medium-chain Triglycerides 0.213g；Maltodextrin 21.46g, resistant starch 13.33g；The dietary fiber selected from inulin, Rhizoma amorphophalli powder, oligomeric galactose, At least one in oligofructose, oligomeric isomaltose, soybean polysaccharide, cyclodextrin, resistant dextrin, soybean fiber, its gross mass For 5.99g, wherein water soluble dietary fiber 4.83g, fat-soluble dietary fiber 1.16g；Calcium 0.6g in macroelement, phosphorus 0.21g, Potassium 0.08g, sodium 0.02g, magnesium 0.15g；Ferrum 0.011g, iodine 0.00014g, zinc 0.007g in trace element；In fatsoluble vitamin Vitamin A 0.0006g, beta-carotene 0.000057g, vitamin D₃0.000001g, Vitamin E 0.009g；Water soluble vitamin Vitamin B in raw element₁0.001g, vitamin B₂0.001g, vitamin B 60.001g, vitamin B₁₂0.000002g, dimension life Plain C 0.117g, pantothenic acid 0.003g, Folic Acid 0.000165g, nicotinic acid 0.0165g；Oatmeal 0.333g；It is thin in integration of edible and medicinal herbs composition Lotus 0.1g, Exocarpium Citri Rubrum 0.1g, Rhizoma Dioscoreae 0.05g, Bulbus Allii Macrostemonis 0.05g, Fructus Lycii 0.05g, Fructus Jujubae 0.05g, Arillus Longan 0.1g, Pericarpium Citri tangerinae 0.1g； L-carnitine 0.633g in natural plants compound；Newborn mineral salt 0.05g, oligochitosan 0.05g in new resource food.

Embodiment 8

The preparation method of the nutritive powder of the fracture tailored version clinical nutrition formula containing embodiment 1- embodiment 7 is as follows：

1) prepare powdered oil：By the fat of predetermined weight with sucrose ester, monoglyceride, maltodextrin, water at 70 DEG C or so Carry out mixed dissolution and prepare emulsion, the wherein consumption of sucrose ester and monoglyceride for emulsion weight 2.5%～5%, water 10～15 times for fat weight of consumption, maltodextrin consumption for emulsion weight 8%～20%；Above-mentioned emulsion is stirred After 2～5min of mixing, 2 emulsifying homogeneous being carried out under high pressure and being processed, the emulsifying homogeneous time is 12～18min；Then sprayed Mist is dried, and prepares powdered oil with 60～80 mesh sieves point；

2) prepare meals elite powder：The meals elite raw material of predetermined weight is cleaned up into loading vacuum lyophilization Device, predrying is 45～55% to water content, and it is -25 DEG C～-35 that precooling to temperature is carried out to raw material in 1～1.5h then DEG C, evacuation is carried out to vacuum freeze dryer then so as to which vacuum maintains 40～60Pa, temperature is raised and maintained 50～60 DEG C, 20h is dried, when water content is 1%～2.5%, raw material is taken out from vacuum freeze dryer, carry out crushing, 80 mesh sieves are crossed, meals elite powder is obtained；

3) integration of edible and medicinal herbs component powders are prepared：By the integration of edible and medicinal herbs composition of predetermined weight be put into pulverizer carry out crushing, mistake 60～80 mesh sieves make integration of edible and medicinal herbs component powders；

4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, the life of fat-soluble dimension Element, water soluble vitamins, meals elite, natural plants compound and new resource food are prepared into particle diameter respectively for 100～300 μm powdery；

5) by step 1)～step 4) obtained by powder mix homogeneously, with obtain wound, infection, operation and other should Sharp state nutritive powder, after sterilization processing, fill is in sterilized packaging bag or is placed directly within sterilized pail pack In.

Aforesaid operations step is both needed to carry out under the protection of noble gases, such as nitrogen protection, to prevent that powder is quick-fried Fried danger.

Embodiment 9

The preparation method of the nutrition emulsion of the fracture tailored version clinical nutrition formula containing embodiment 1- embodiment 7 is as follows：

4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, the life of fat-soluble dimension Element, water soluble vitamins, natural plants compound and new resource food are prepared into the powdery that particle diameter is 100～300 μm respectively；

5) by step 4) in protein powder be dissolved in temperature be 20～25 DEG C, abundant water in the pure water of 280～350g Change 3～15h, obtain in protein aqueous solution, then by step 4) in carbohydrate powder, macroelement powder, micro unit Plain powder, water soluble vitamins powder are dissolved in protein aqueous solution, carry out gentle agitation, and the water being uniformly mixed mixes Liquid；

6) by step 1) in microcapsule embedding treatment after fat powder, step 2) in prepare meals elite powder, step It is rapid 3) in prepare integration of edible and medicinal herbs component powders, step 4) in prepare fatsoluble vitamin powder and natural plants compound powder End sequentially adds step 5) in gained aqueous phase solution, and carry out strong agitation, addition emulsifying agent and thickening agent obtain mixing equal Even concentrated emulsions；

7) in step 6) described in concentrated emulsions in add 20～25 DEG C, the pure water of 100～170g stir, while going The foam of skim-coat, obtains Emulsion, then by Emulsion under 300～600Bar homogenizing, homogenisation cycle number of times be 2-5 time, then Sterilize at 110～130 DEG C, be cooled to room temperature, nutrition emulsion is obtained, and by nutrition emulsion fill in sterilized packaging bag In.

Fracture experiment

1～embodiment of embodiment 7 is respectively taken into 300g, 75% ethanol solution 750ml, heating and refluxing extraction is separately added into 1.5h, cooling, filtration collect filtrate, and insoluble matter repeats above extraction process 3 times.Merging filtrate, is sloughed on a rotary evaporator Solvent.Each extract is separately added into α-MEM culture medium 20ml, adds micro twen-80 hydrotropy, filtration sterilization, is configured to containing carrying Take the α-MEM culture medium (1～embodiment of embodiment 7) of thing.

The SD neonatal rats 8 of birth 4d are chosen, and at anesthesia Cervical vertebra dislocation, after death 10min are soaked with 75% ethanol, Peel off under aseptic condition and take out parietal bone, when dissected retains the cerebral dura mater of its outer surface periosteum and inner surface.Rushed with α-MEM culture fluid After washing 3 times, be put into containing 15% hyclone, 20mmol/L HEPES, 1000U/ml penicillins, 1000mg/L streptomycins α- In the culture dish of MEM culture medium, each parietal bone is pruned and is divided into 4 pieces.Osteocomma is put in 24 well culture plates, 7 are randomly divided into The individual experimental group containing osteocomma and 1 blank group without osteocomma, per group contains 4 osteocommas, is separately added into containing 10% tire cattle per hole Serum, 20mmol/L HEPES, 100U/ml penicillins, α-MEM culture medium 2ml of 100mg/L streptomycins, in 37 DEG C, 5%CO2 24h is cultivated in incubator.Second day changes liquid, adds α-MEM culture medium 2ml (blank group adds α-MEM culture medium) containing extract, Cultivate 1 respectively according to different time, 3,7,10d, liquid 1 time is changed per 3d.

Calcium ion concentration is detected：Culture supernatant 0.5ml is collected respectively, after diluting 20 times with the ultra-pure water of resistance 18M Ω, Total calcium content is determined with atomic absorption spectrophotometer, and is subtracted each other with culture medium calcium ion concentration in the blank group without osteocomma, (* is represented and significant difference, P is compared with blank group to calculate the changing value of calcium ion concentration<0.05；* is represented and is compared with blank group Significant difference, P<0.01), as a result as shown in table 1.

Impact (n=4) of the 1 each embodiment of table to culture medium calcium ion concentration change in bone incubation

Shown by upper table result, respectively after culture 1,3,7,10d, and blank group contrast, 1～embodiment of embodiment, 7 tissue culture Foster base calcium ion concentration variable quantity has significant change, and wherein embodiment 1 cultivates 7 days (P<0.05), 10 days (P<0.01) it is, and real Apply 2 tissue culture of example and support 10 days (P<0.05), significant difference.Illustrate that 1～embodiment of embodiment 7 can promote osteoblast, increase to calcium The absorption of ion, accelerates bone repair.

Suppress osteoclast detection：After culture 10d, parietal bone is taken out, with the 4 DEG C of fixations of 95% ethanol and 5% glacial acetic acid 10min.After PBS rinses 3 times, osteocomma is immersed into (six azo paramagenta 1ml, 0.2mom/L acetate buffer solutions in stain incubation liquid 18ml, naphthols AS-BI phosphate 20mg, tartrate 50mmol), 37 DEG C of lucifuges incubation 30min, distilled water flushing 3 times, immediately Resinenes sealing, light Microscopic observation is used simultaneously to count red or mauve tartaric-resistant positive cell.

After 2 each embodiment 10d of table, Mus parietal bone Tartrate resistant acid phosphatase positive cell compares (n=4)

Tartrate resistant acid phosphatase positive staining is the characteristic mark of osteoclast, as seen from the above table, and blank group Compare, the Tartrate resistant acid phosphatase positive cell of each embodiment experiment has certain reduction, and wherein 1 group of reduction of embodiment shows Write (P<0.05).Illustrate that 1～embodiment of embodiment 7 can suppress osteoclast, reduce the differentiation of osteoclast or accelerate its apoptosis, Reduce bone resorption.

As bone metabolism process is the collective effect of osteoblast and osteoclast, above experiment further illustrates embodiment 1～embodiment 7 can act on osteoblast, can act on osteoclast again, accelerate bone repair.

From above-described embodiment, in fracture tailored version clinical nutrition formula of the present invention, various components mutually match Close, more reasonable, comprehensive nutritional support is provided for tumor patient, while add and increasing bone density, infection, enriching blood, nurse one's health The integration of edible and medicinal herbs composition of digestion, natural plants compound and new resource food, contribute to knitting, the reinforcement of fracture patient Matter, improves therapeutic effect；Can be shown that the fracture tailored version clinical nutrition of present invention preparation is matched somebody with somebody and can be promoted into by above-mentioned experiment Osteocyte, increases absorption to calcium ion, accelerates bone repair, while suppress osteoclast, reduce osteoclast differentiation or Accelerate its apoptosis, reduce bone resorption.

Above the specific embodiment of the present invention is described in detail, but which has been only used as example, the present invention has been not intended to limit In particular embodiments described above.To those skilled in the art, any equivalent modifications carried out by the practicality and replace In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and is repaiied Change, should all cover within the scope of the invention.

Claims

1. a kind of fracture tailored version clinical nutrition formula, it is characterised in that including the component of following parts by weight：20-35 part eggs White matter, 5-15 parts fat, 28-40 part carbohydrates, 3-9 part dietary fibers, 0.5-1.5 part macroelements, 0.01-0.03 parts Trace element, 0.005-0.02 part fatsoluble vitamiies, 0.08-0.2 part water soluble vitamins, 0.1-1 part meals elite, 0.2- 8 parts of integration of edible and medicinal herbs compositions, 0.5-1.2 part natural plants compounds and 0.05-0.8 part new resource foods；

Wherein, the integration of edible and medicinal herbs composition selected from Herba Menthae, Exocarpium Citri Rubrum, Rhizoma Dioscoreae, Bulbus Allii Macrostemonis, Fructus Lycii, Fructus Jujubae, Arillus Longan, in Pericarpium Citri tangerinae extremely Few one kind；

Wherein, the new resource food selected from first milk basic protein, γ-aminobutyric acid, oligochitosan, eucommia Bark male flower, Folium Bambosae flavone, At least one in phosphopeptide caseinate, avenabeta glucosan, newborn mineral salt, yeast beta-dextran, leaf of Moringa, oligomeric xylose.

2. a kind of fracture tailored version clinical nutrition formula according to claim 1, it is characterised in that the integration of edible and medicinal herbs into In point, the parts by weight of each component are as follows：Herba Menthae 0-0.2 parts, Exocarpium Citri Rubrum 0-0.2 part, Rhizoma Dioscoreae 0-0.25 parts, Bulbus Allii Macrostemonis 0-0.2 parts, Chinese holly Qi 0-0.2 part, Fructus Jujubae 0-0.2 parts, Arillus Longan 0-0.2 parts, Pericarpium Citri tangerinae 0-0.2 parts.

3. a kind of fracture tailored version clinical nutrition formula according to claim 1, it is characterised in that in the protein Protein peptide is selected from soybean oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, the white of an egg At least one in protein peptide, Calcium peptide of casein.

4. a kind of fracture tailored version clinical nutrition formula according to claim 1, it is characterised in that the natural plants Compound is selected from L-carnitine, glucosamine, oligofructose, phylloxanthin, plant sterol, lycopene, resveratrol, garlicin In at least one.

5. a kind of fracture tailored version clinical nutrition formula according to claim 1, it is characterised in that the protein and ammonia The high quality protein weight provided in base acid accounts for more than the 70% of gross protein weight.

6. a kind of fracture tailored version clinical nutrition formula according to claim 1, it is characterised in that n-6 in the fat The ratio of fatty acid and n-3 fatty acids is 3～4:1.

7. it is a kind of it is as claimed in claim 1 fracture tailored version clinical nutrition formula preparation method, it is characterised in that the fat Fat makes powder using microcapsule embedding techniqueses, and the meals elite makes powder, the medicine food using freeze drying process With derived components by crushing, sieving and make powder.

8. preparation method according to claim 7, it is characterised in that the mesh number that the integration of edible and medicinal herbs composition sieves is 60- 80 mesh.