CN107242550A - A kind of male sterility tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of male sterility tailored version clinical nutrition formula and preparation method thereof Download PDF

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CN107242550A
CN107242550A CN201710516558.9A CN201710516558A CN107242550A CN 107242550 A CN107242550 A CN 107242550A CN 201710516558 A CN201710516558 A CN 201710516558A CN 107242550 A CN107242550 A CN 107242550A
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male sterility
powder
vitamin
clinical nutrition
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尤俊
季敬东
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SHANGHAI FUDAN AOYI MEDICAL TECHNOLOGY CO LTD
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SHANGHAI FUDAN AOYI MEDICAL TECHNOLOGY CO LTD
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
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  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pediatric Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a kind of male sterility tailored version clinical nutrition formula, it includes 15 40 parts of protein, 28 parts of fat, 40 55 parts of carbohydrate, 5.8 8 parts of dietary fibers, 0.6 1.2 parts of macroelements, 0.01 0.04 parts of trace elements, 0.005 0.02 parts of liposoluble vitamins, 0.008 0.2 parts of water soluble vitamins, 0.05 1 parts of meals elite, 0.1 2 parts of integration of drinking and medicinal herbs compositions, 0.1 3 parts of natural plants compounds and 0.005 5 parts of new resource foods, wherein integration of drinking and medicinal herbs composition is selected from Poria cocos, raspberry, matrimony vine, Chinese yam, spina date seed, oyster, at least one of radix glycyrrhizae；Above-mentioned each component is previously prepared into powder, wherein fat and vitamin are prepared into powder using micro-capsule embedding techniques.Screening and proportioning by said components, nutrient formulation of the present invention provides more reasonable, comprehensive nutritional support for male sterility patient, to improve nutritional status defective mode potential and having occurred, kidney tonifying, invigorating the spleen, soothing the liver composition are added simultaneously, to improve the condition of male sterility person, promote production of sperm ability, improve sperm motility.

Description

A kind of male sterility tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food field, and in particular to a kind of male sterility tailored version clinical nutrition Formula and preparation method thereof.
Background technology
The World Health Organization (WHO) provides that Mr. and Mrs live together more than 1 year after marriage, there is the sexual life of normal rule, does not use and appoints What contraceptives, the wife's side is normal, and the infertile person in the wife's side, referred to as male sterility are caused due to male's aspect.In recent years, it is male The property sterility incidence of disease is gradually risen, and the 15%-20% couple at child-bearing age is there are about according to relevant report, in world wide to be given birth to, The factor on the wherein bridegroom's or husband's side accounts for 50%.The cause of disease of sterility is sufficiently complex, and because man's reproduction link is a lot, main has man The Neuroendocrine regulation of reproductive system, the spermatogenesis of testis, sperm is ripe in epididymis, with essence in sperm discharge process Capsule, the refining of prostatic secretions mix seminal fluid, and sperm is excreted and is input in female genital tract from man's genital tract, Sperm in women fallopian tubal with the link such as ovum fertilization, any one factor or link are interfered and can drawn during these Infertility is played, therefore, up to 60%-75% patient can not find out the specific cause of disease.
For traditional Chinese medical science angle, the kidney being the origin of congenital constitution, and main bone gives birth to marrow, it is main grow, reproduction, main menses and reproduction it Essence.Kidney is because of deficiency, deficiency of kidney-essence, so as to cause semen quality to change, and it is thin lack of quantity of spermatic fluid, seminal fluid quality occur, sperm Lazy weight.The deficiency of Yin not intrinsic energy sun, mutually fire is partially prosperous, and essence closes not solid, can cause to pass out semen, heat of urinating.Deficiency of kidney-QI, qi-blood deficiency can go out The lesions such as existing impotence, seminal emission, sperm motility decline, the reduction of sperm quantity and morphological change, so as to cause male sterility Generation.Therefore the traditional Chinese medical science uses nourishing kidney yin, the method for life essence-filling, marrow-benefitting is to mend its this void, kidney tonifying, essence replenishing, so as to treat male sterility Disease.In addition, the method such as treatment by Chinese herbs, acupuncture, massage also is available for selection.
For doctor trained in Western medicine angle, after the diagnosis of clear and definite male sterility, the assessment of detailed fertility need to be done to the wife's side, then select Select medical treatment or surgical intervention.Medical treatment mainly has prophylactic treatment and drug therapy.Wherein, the cause of disease is examined in drug therapy It is disconnected clear and definite, there is etiotropic therapeutic measures person, therapeutic effect is then more satisfied with, such as gonadotropin hormone treatment；Pulsed GnRH is treated；Promote endogenous gonadotrophin secretion；Other treating endocrine diseases etc..When the cause of disease is clear and definite but this cause of disease is drawn When the mechanism for playing infertility is not yet illustrated, therapeutic effect is often not enough satisfied with.It is organic for some in male sterility patient Lesion, it is impossible to solved by medicine, can take operative treatment.
Auxiliary procreation technology (assisted reproductive technology, ART), refers to and is arranged with various medical treatment Apply, infertile Mr. and Mrs is become pregnant the general designation of method, including artificial insemination, vitro fertilization-embryo implanting.Its process is using non- The mode that sexual intercourse means are become pregnant is, it is necessary to which the related personnel such as clinician and laboratory technicians joint operation treatment men and women is infertile The important means of infertility.Human sperm bank and the part that sperm super-low temperature preservation is also auxiliary procreation technology.
With molecular biology, physiology, clinical medical development, modern nutritional support starts to play " pharmacology nutrition " Effect.For can cause male sterility such as dysspermatism, dyszoospermia, sperm and ovum combination obstacle and it is systemic because Plain the problems such as, modern clinic nutrition can improve, nurse one's health physical function, and appropriate nutrients is provided by suitable approach Matter, corrects abnormal pathologic, the physiological change of patient, maintains body cell and tissue, the normal configuration and function of organ, improves body Voxel matter, improves therapeutic effect.
Pass through clinical nutrition auxiliary treatment male sterility, it is possible to the drug treatment of abundant male sterility, or can Some beneficial complements are provided for the treatment of sterility, so as to improve clinical efficacy.
At present, for the treatment of male sterility, the medicine and operative treatment of doctor trained in Western medicine, and the traditional Chinese medical science are included to the tune of internal organs Physiotherapy method, acupuncture and massage, they all lack the supply to the overall nutrition of human body, it is impossible to meet need of the body to various nutrients Ask.Therefore, develop can provide basal nutrient needed for male sterility patient it is plain while, special dietary can be supplemented again and is usually carried The product of high therapeutic effect, with important value and wide market.
The content of the invention
It is an object of the invention to overcome defect of the prior art to match somebody with somebody there is provided a kind of male sterility tailored version clinical nutrition Side and preparation method thereof.
Nutrient refers to the chemical composition for providing energy, participation body composition and regulation of physiological functions in food to human body. Nutrition necessary to human body have protein, lipid, carbohydrate, mineral matter, vitamin, water, dietary fiber etc..Some research hairs Existing, many nutrients are relevant with Hypothalamus-pituitary-testicular germ s function and spermatogenesis, maturation, capacitation, acrosome reaction etc.. The purpose of the present invention provides the nutritional support of comprehensive abundance for male sterility person, to improve nutritional status potential and having occurred not Good state, while adding kidney tonifying, invigorating the spleen, soothing the liver integration of drinking and medicinal herbs composition, to improve the condition of male sterility person, promotes life Smart ability, improves sperm motility.
To achieve the above object, the present invention is adopted the following technical scheme that：
On the one hand, the present invention provides a kind of male sterility tailored version clinical nutrition formula, including following component and its weight Number：15-40 parts of protein, 2-8 parts of fat, 40-55 parts of carbohydrate, 5.8-8 parts of dietary fibers, 0.6-1.2 parts of constants Element, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.05-1 parts of meals elite, 0.1-2 parts of integration of drinking and medicinal herbs compositions, 0.1-3 parts of natural plants compounds and 0.005-5 parts of new resources Food.
In order to further optimize above-mentioned technical proposal, the technical measures that the present invention is taken also include：
Preferably, the protein be selected from PURE WHEY, hydrolysis Isin glue collagen, soybean protein isolate, whole milk powder, At least one of dried whole-egg, lactoferrin, colostrum, amino acid, protein peptides；
Wherein, the amino acid is selected from 1B-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, ILE, L-Leu；The protein peptides are selected from soy oligosaccharides At least one of peptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide.
Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically it is described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm Oil, butter, cream, lard, medium chain triglyceride, lecithin etc..
Preferably, the carbohydrate is included in fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least two.
Preferably, the dietary fiber comprising inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one of soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber.
Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate At least one of with magnesium gluconate.
Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.
Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, vitamin K1At least one of.
Preferably, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin At least one of C, pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean At least one of powder, soy meal；The potato class is mainly made up of common yam rhizome powder；The Vegetable powder is selected from carrot meal, white radish powder, south At least one of melon powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae be selected from mushroom powder, Kelp Powder and At least one of white fungus powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch；The fish and shrimp Selected from least one of salmon powder and cod meal；The poultry meat in chicken meal, powdered beef and pig kidney powder extremely Few one kind；The fruits are selected from least one of red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder；More Preferably pumpkin seed powder, Kelp Powder, powdered beef and pig kidney powder.
Preferably, the integration of drinking and medicinal herbs composition is in Poria cocos, raspberry, matrimony vine, Chinese yam, spina date seed, oyster, radix glycyrrhizae It is at least one；More preferably Poria cocos, raspberry, matrimony vine, Chinese yam, spina date seed, oyster.
Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one of sterol, lycopene, resveratrol, allicin；More preferably l-cn.
Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo In leaf flavones, CPP, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii, xylo-oligosaccharide At least one；More preferably newborn mineral salt, pueraria root powder, Rosa roxburghii and avenabeta glucosan.
Preferably, the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：0-1 parts of Poria cocos, 0-1 parts of raspberry, 0-1 parts of matrimony vine, 0-1 parts of Chinese yam, 0-1 parts of spina date seed, 0-1 parts of oyster.
Preferably, the good protein weight provided in the protein accounts for more than the 70% of gross protein weight.
Preferably, n-6 aliphatic acid in the male sterility tailored version clinical nutrition formula：N-3 aliphatic acid=3~4:1.
Preferably, ascorbic parts by weight are 0.102 part in the water soluble vitamin.
Preferably, the parts by weight of element zinc are 0.016 part in the trace element.
On the other hand, the present invention also provides a kind of preparation method side of above-mentioned male sterility tailored version clinical nutrition formula Method, it comprises the following steps：
Step 1) fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques End；
Step 2) integration of drinking and medicinal herbs component powders are prepared using crushing, decoction, spray drying and sifting step；
Step 3) protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals are smart China, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；
Step 4) by step 1)-step 3) and obtained by powder sequentially add mixer it is well mixed after formula mixing is made Thing, it is standby after sterilization processing；
Step 5) according to conventional technical means by step 4) in formula mixture be prepared into nutrient powder, nutrition emulsion, glue At least one of wafer, tablet, pill or oral liquid.
Finally, the present invention relates to a kind of product prepared by above-mentioned male sterility tailored version clinical nutrition formula, including battalion Support powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..
In above-mentioned preparation method, wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, water extraction concentration, and will be dense Contracting liquid carries out spray drying and integration of drinking and medicinal herbs component powders is made；Wherein, the vitamin and fat respectively by microencapsulation at Reason is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, is added 3~8 times of the water that weight is raw material weight, is carried out immersion 3 ~4 hours, then soak is carried out to decoct 30~60min, filtering removes raw material, leaves and takes decoction liquor, spray decoction liquor Mist is dried, prepares integration of drinking and medicinal herbs component powders with 60~80 mesh sieves point.
Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) it regard liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer are as wall material, high-pressure homogeneous emulsification, and spraying is instantaneous to be dried, with 60~80 mesh sieves Divide and prepare liposoluble vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, OK a karaoke club Glue, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum One or more works in powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer For wall material, it is well mixed, spraying is instantaneous to be dried, and water soluble vitamin powder is prepared with 60~80 mesh sieves point.
Preferably, the specific implementation step of the fatty micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall material with Water mixed dissolution prepares emulsion；After the stirring mixing of above-mentioned emulsion, emulsifying homogeneous processing is carried out, spraying is then carried out dry Dry, screening prepares fat powder, and fat powder is compared with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), One in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin, monoglyceride, Tween 80 Plant or a variety of；The wall material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, fat egg In vain, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean One or more in fiber, lactose, candy sugar powder, emulsifying agent, stabilizer.
It is above-mentioned using Poria cocos, raspberry, matrimony vine, Chinese yam, spina date seed, the integration of drinking and medicinal herbs composition of oyster is included in the present invention Composition has kidney tonifying, invigorating the spleen, soothing the liver effect.
Triterpenes, water-soluble polysaccharide and acidic polysaccharose play the role of to adjust immunologic function in Poria cocos, can make mice serum Interior immune factor IL-2 and TNF-α content substantially increase, and wherein pachymaran can also such as increase IL- to affecting cells 2nd, TNF, IL-6, IFN-γ potency, the function of improving lymphocyte and macrophage, cause anti-Patrick's knot, lymphonodi mesenterici In CD3+, CD19+ cell proportion change and promote mice serum in IgA, IgG and IgM biosynthesis.
Raspberry is the dry fruit of rosaceous plant rubus chingii Hu, with kidney-nourishing, controlling nocturnal emission with astringent drugs, contracting urine effect, for kidney The treatment of the diseases such as the empty enuresis, frequent urination, impotence and premature ejaculation, emission and spermatorrhea.Raspberry aqueous extract can reduce experimental rat inferior colliculus Brain LHRH, hypophysis LH, FSH and sexual gland E2 contents, and improve thymus gland LHRH and blood T levels.Research shows raspberry Aqueous extracts It is probably the pharmacological basis of its " the puckery essence of kidney tonifying " to the regulating and controlling effect of gonad axis.
LBP-X has repair to hepatic injury caused by carbon tetrachloride in matrimony vine, and its mechanism may be by prevention The damage of matter net, promotes protein synthesis and detoxication, recovers the function of liver cell, and promote liver cell regeneration；Matrimony vine is thick Polysaccharide can reduce hepatic tissue mda content, and carbon tetrachloride hepatic injury mouse liver glycogen content can be made significantly to raise, and improve human body Energy reserve；The active ingredient in matrimony vine can improve mitochondrial form to alcoholic liver disease of rats model, mitigate liver simultaneously The steatosis and inflammation degree of necrosis of cell.
Spina date seed aqueous extract has obvious antiinflammatory action, can suppress mouse peritoneal, skin of back and auricle blood capillary Pipe permeability, has inhibitory action to the granuloma that the swelling of rat hindleg egg white and the rat oxter implantation scraps of paper are produced, has Effect of strengthen immunity.
The traditional Chinese medical science thinks, caused by infertility system " syndrome of deficiency of kidney yang ", " syndrome of deficiency of kidney yin ", " kidney essence deficiency ".Infertility side is thrown, point Kidney-replenishing is not taken, mend lean blood, nourishing and suppressing Yang, the medicine of enriching essence and nourishing marrow, positive female engagement beneficial to spirit and marrow, so as to reach treatment kidney deficiency The purpose of defective ejaculation, infertility.
Chinese yam especially Chinese yam polysaccharide has good immunoregulation effect, and Chinese yam can extend the low mouse of immunity function The hypoxic tolerance time, improve spleen index, thymus index (P<0.05) thymus gland, the institutional framework of spleen, are improved.
Oyster nutrition liquid energy significantly reduces the blood urea nitrogen and blood lactase acid level of mouse, improves blood lactase acid resume speed, together When can significantly extend the mice burden swimming time, oyster nutrient solution has antifatigue effect.
The present invention also adds the vitamin C of specified quantitative.Vitamin C energy high-efficient cleaning removes ascorbic concentration in ROS, refining It is higher 10 times than in blood, the not oxidized destruction of sperm membrane lipid and sperm DNA can be protected to exempt to be damaged.Increase is ascorbic Intake can increase the percentage of sperm motility rate and eupyrene sperm.In addition, vitamin C can reduce sperm cohesiveness in the cell, Be conducive to semen liquefaction.Clinically it is proved effective in cure to nonliquefaction of semen person with replenishing vitamins C therapy.
The present invention also adds the trace element zinc of specified quantitative.Zinc can promote gonad development, participation immunity of organism, composition a variety of Enzyme necessary to reproduction.Zinc in males is focused primarily upon in the organs such as testis, epididymis and prostate, can remove unnecessary ROS, Increase LH, T secretion, promote testicualr development and Sperm specific enzyme, improve Sperm Motility, combined with Sperm Chromatin sulfydryl anti- Only DNA fracture and depolymerization of being end-to-end etc..Infertile patients Seminal plasma zinc concentration is substantially less than fertile men, blood zinc concentration without Notable difference, and Seminal plasma zinc concentration is proportionate with sperm concentration, sperm motility and sperm motility rate, but the zinc of excessive concentrations Production of sperm can be suppressed.
Maca ene and the most valuable work(of macamide in the present invention also new resource food such as addition pueraria root powder, pueraria root powder Effect is that human hormone can be kept to secrete dynamic equilibrium, and this has extraordinary effect to improving sexual function of human body obstacle；In maca Arginine be sperm important composition composition, for increase sperm quantity have extraordinary effect, male can be effectively improved Fecundity.Fructose is rich in maca, the vigor of mankind spermatozoon can be effectively improved, male fecundity is improved；Mustard in maca Seed oil glycosides and its volatile oil component have the effect of extraordinary enhancing immune system, and this composition can effectively consolidate human body and exempt from Epidemic disease system, improves sub-health state.
Compared with prior art, the invention has the advantages that：
(1) present invention addition has kidney tonifying, invigorating the spleen, the integration of drinking and medicinal herbs composition and new resource food of soothing the liver effect, its each group Divide and complement each other, determined curative effect can improve the condition of male sterility person, promote production of sperm ability, improve sperm motility；
(2) present invention also adds the vitamin C and trace element zinc of specified quantitative, promotes testicualr development and Sperm specific enzyme, carries The percentage of high Sperm Motility, increase sperm motility rate and eupyrene sperm；
(3) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, it is easy to be well mixed with other powdered components；And use micro-capsule bag Bury after technology, grease is embedded in wall material, so that the contact with air is avoided to strengthen inoxidizability, so as to play guarantor The maximum effect of strong type grease.
(4) raw material of male sterility tailored version clinical nutrition formula of the present invention is previously prepared in preparation process Into 150~250 μm of powder, this make it that, when preparing finished product, each nutrition composition can be well mixed, it is ensured that in unit volume The content of each nutrition composition is essentially identical, while when preparing liquid type preparation, each nutrition composition can be fully dispersed and completely molten Solution prevents occurring solid precipitation in liquid into solvent, and effect of finished product product has been effectively ensured.
The present invention is by from rational basal nutrient element, using the proportioning of general equilibrium, while addition is with kidney tonifying, strong The specific nutrients such as spleen, the integration of drinking and medicinal herbs composition of soothing the liver effect, natural plants compound, new resource food, and adjust its proportioning Compatibility synergy is carried out with basal nutrient element, so that the nutrient formulation of allotment is easier to be absorbed by male sterility people digest, Effect of its abundant component, improves the condition of male sterility person, promotes production of sperm ability, improves sperm motility.
Embodiment
The present invention provides a kind of clinical nutrition formula special for male sterility, including following component and its parts by weight Number：15-40 parts of protein, 2-8 parts of fat, 40-55 parts of carbohydrate, 5.8-8 parts of dietary fibers, 0.6-1.2 parts of constant members Element, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.05- 1 part of meals elite, 0.1-2 parts of integration of drinking and medicinal herbs compositions, 0.1-3 parts of natural plants compounds and 0.005-5 parts of new resource foods.
With reference to embodiment, the embodiment to the present invention is further described.Following examples are only used for more Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.
Embodiment 1
The special clinical nutrition formula of male sterility of the present invention includes PURE WHEY 17g, soybean protein isolate 3.55g, whole milk powder 12.1g, dried whole-egg 0.33g, colostrum 0.17g, taurine 0.12g；Olive oil 0.92g, soybean oil 1.49g, coconut oil 0.92g, perilla herb oil 0.21g, medium chain triglyceride 0.07g；Maltodextrin 24.23g, tapioca 10g, ice Sugared 6.23g, lactose 0.67g；Water-soluble dietary fiber 6g, insoluble diedairy fiber 1.16g in dietary fiber；Calcium in macroelement 0.53g, phosphorus 0.23g, potassium 0.05g, sodium 0.15g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc in trace element 0.016g；Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D in liposoluble vitamin30.000001g, dimension Raw element E 0.008g；Vitamin B in water soluble vitamin10.001g, vitamin B20.001g, vitamin B60.0002g, dimension Raw element B120.000001g, vitamin C 0.102g, pantothenic acid 0.003g, folic acid 0.000023g, nicotinic acid 0.0133g；Pumpkin seeds Powder 0.07g, Kelp Powder 0.03g, powdered beef 0.17g, pig kidney powder 0.07g；Poria cocos 0.17g, raspberry in integration of drinking and medicinal herbs composition 0.17g, matrimony vine 0.17g, Chinese yam 0.17g, spina date seed 0.17g, oyster 0.17g；L-cn 2g in natural plants compound；Newly Rosa roxburghii 0.33g, pueraria root powder 3.3g, newborn mineral salt 0.16g, avenabeta glucosan 0.03g in resource food.
Embodiment 2
The special clinical nutrition formula of male sterility of the present invention includes PURE WHEY 17g, soybean protein isolate 3.55g, whole milk powder 12.1g, dried whole-egg 0.33g, colostrum 0.17g, taurine 0.12g；Olive oil 0.92g, soybean oil 1.49g, coconut oil 0.92g, perilla herb oil 0.21g, medium chain triglyceride 0.07g；Maltodextrin 24.23g, tapioca 10g, ice Sugared 6.23g, lactose 0.67g；Water-soluble dietary fiber 6g, insoluble diedairy fiber 1.16g in dietary fiber；Calcium in macroelement 0.53g, phosphorus 0.23g, potassium 0.05g, sodium 0.15g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc in trace element 0.016g；Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D in liposoluble vitamin30.000001g, dimension Raw element E 0.008g；Vitamin B in water soluble vitamin10.001g, vitamin B20.001g, vitamin B60.001g, dimension Raw element B120.000005g, vitamin C 0.102g, pantothenic acid 0.003g, folic acid 0.000223g, nicotinic acid 0.0133g；Pumpkin seeds Powder 0.17g, Kelp Powder 0.33g, powdered beef 0.17g, pig kidney powder 0.07g；Poria cocos 0.17g, raspberry in integration of drinking and medicinal herbs composition 0.17g, matrimony vine 0.17g, Chinese yam 0.17g, spina date seed 0.17g, oyster 0.17g；L-cn 2g in natural plants compound；Newly Rosa roxburghii 0.33g, pueraria root powder 3.3g, newborn mineral salt 0.16g, avenabeta glucosan 0.03g in resource food.
Embodiment 3
The special clinical nutrition formula of male sterility of the present invention includes PURE WHEY 17g, soybean protein isolate 3.55g, whole milk powder 12.1g, dried whole-egg 0.33g, colostrum 0.17g, taurine 0.12g；Olive oil 0.92g, soybean oil 1.49g, coconut oil 0.92g, perilla herb oil 0.21g, medium chain triglyceride 0.07g；Maltodextrin 24.23g, tapioca 10g, ice Sugared 6.23g, lactose 0.67g；Water-soluble dietary fiber 6g, insoluble diedairy fiber 1.16g in dietary fiber；Calcium in macroelement 0.53g, phosphorus 0.23g, potassium 0.05g, sodium 0.15g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.016g in trace element； Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D in liposoluble vitamin30.000001g, vitamin E 0.008g；Vitamin B in water soluble vitamin10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12 0.000005g, vitamin C 0.102g, pantothenic acid 0.003g, folic acid 0.000223g, nicotinic acid 0.0133g；Pumpkin seed powder 0.17g, Kelp Powder 0.33g, powdered beef 0.17g, pig kidney powder 0.07g；Poria cocos 0.07g, raspberry 0.07g, matrimony vine in integration of drinking and medicinal herbs composition 0.07g, Chinese yam 0.07g, spina date seed 0.07g, oyster 0.07g；L-cn 2g in natural plants compound；In new resource food Rosa roxburghii 0.33g, pueraria root powder 3.3g, newborn mineral salt 0.16g, avenabeta glucosan 0.03g.
Embodiment 4
The special clinical nutrition formula of male sterility of the present invention includes PURE WHEY 10g, soybean protein isolate 10.55g, whole milk powder 12.1g, dried whole-egg 0.33g, colostrum 0.17g, taurine 0.12g；Olive oil 0.92g, soybean oil 1.49g, coconut oil 0.92g, perilla herb oil 0.21g, medium chain triglyceride 0.07g；Maltodextrin 24.23g, tapioca 10g, ice Sugared 6.23g, lactose 0.67g；Water-soluble dietary fiber 6g, insoluble diedairy fiber 1.16g in dietary fiber；Calcium in macroelement 0.53g, phosphorus 0.23g, potassium 0.05g, sodium 0.15g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc in trace element 0.016g；Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D in liposoluble vitamin30.000001g, dimension Raw element E 0.008g；Vitamin B in water soluble vitamin10.001g, vitamin B20.001g, vitamin B60.001g, dimension Raw element B120.000005g, vitamin C 0.102g, pantothenic acid 0.003g, folic acid 0.000223g, nicotinic acid 0.0133g；Pumpkin seeds Powder 0.17g, Kelp Powder 0.33g, powdered beef 0.17g, pig kidney powder 0.07g；Poria cocos 0.17g, raspberry in integration of drinking and medicinal herbs composition 0.17g, matrimony vine 0.17g, Chinese yam 0.17g, spina date seed 0.17g, oyster 0.17g；L-cn 2g in natural plants compound；Newly Rosa roxburghii 0.03g, pueraria root powder 0.3g, newborn mineral salt 0.16g, avenabeta glucosan 0.03g in resource food.
Embodiment 5
A kind of preparation method of the special clinical nutrition formula of male sterility as described in embodiment 1- embodiments 4 is as follows：
1) powdered oil (powder fat) is prepared：
A) the wall material aqueous solution is prepared：Take 8 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, dietary fiber 2 Gram (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, Arabic gum 0.2 gram, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stirs and (has ready conditions and heat while stirring to 60 DEG C, kept for 30 points Room temperature is cooled to after clock).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 3.39 milliliters of greases monoglyceride 0.86 milliliter, 1.4 milliliters of soybean oil, 0.86 milliliter of coconut oil, 0.20 milliliter of perilla herb oil, 0.07 milliliter of medium chain triglyceride).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1 gram (total solid concentration is 0.2%) to enter after mixed solution, is settled to water Disperse 2 minutes at a high speed under 200 milliliters (total solid concentration is 25%), 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).
G) obtained emulsion is spray-dried, EAT is 195 DEG C, leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, add weight be raw material weight 3~8 times of water, carry out immersion 3~4 hours, then to immersion Liquid carries out decocting 30~60min, and filtering removes raw material, leaves and takes decoction liquor, decoction liquor is spray-dried, with 60~80 mesh sieves Divide and prepare integration of drinking and medicinal herbs component powders；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material Mist is instantaneously dried, and liposoluble vitamin powder is prepared with 60~80 mesh sieves point；The water soluble vitamin of predetermined weight number is made For core, from maltodextrin, lipoprotein as wall material, it is well mixed, spraying is instantaneous to be dried, and water is prepared with 60~80 mesh sieves point Soluble vitamin powder；
4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；
5) by step 1)~step 4) obtained by powder sequentially add the mixers of cone-type mixer or other forms and mix Uniformly obtained formula mixture is closed, it is standby after sterilization processing；
6) according to conventional technical means by step 5) in formula mixture be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral liquid.
In step 6) in, optionally increase appropriate food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, flavoring essence spices, brown sugar；More preferably carragheen, Arabic gum, Guar Glue, Aspartame, flavoring essence spices.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent production The danger of green powder blast.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
The infertility experiment of embodiment 6- male mices
1) influence of the tailored version clinical nutrition formula that the present invention is provided to male mouse infertility.
The nutrient powder for taking the embodiment of the present invention 1~4 to prepare is tested, while setting comparative example 1, comparative example 2, comparative example 1 Using nutrient powder prepared by zinc gluconate, pumpkin seed powder, Kelp Powder, pueraria root powder is deleted in the nutrient formulation of embodiment 2, contrast Example 2 is using nutrient powder prepared by integration of drinking and medicinal herbs composition is deleted in the nutrient formulation of embodiment 2, blank control group feeding is normal to raise Material.
Wistar male rats 96 are taken, the modeling of sterility is carried out to male rat with gossypol.Experimental animal is divided at random Into totally 8 groups of Normal group, model group, administration group 1, administration group 2, administration group 3, administration group 4, administration group 5, administration group 6, administration Group 1,2,3,4 distinguishes the nutrient formulation that stomach raises embodiment 1,2,3,4, and the difference stomach of administration group 5,6 raises comparative example 1, comparative example 2.
The tailored version clinical nutrition of table 1 is formulated the influence to male rat body weight
Group First body weight/g Whole body weight/g Weightening/g
Administration group 1 26.3 44.2 17.9
Administration group 2 28.1 46.8 18.7
Administration group 3 27.8 45.9 18.1
Administration group 4 26.3 44.6 18.3
Administration group 5 25.8 42.3 16.5
Administration group 6 26.9 42.6 15.7
Control group 27.4 41.6 14.2
Model group 27.3 43.2 15.9
Table 1 understands that administration group 1,2,3,4,5,6 is compared with control group, P ＜ 0.05, illustrates clinical nutrition formula to rat Weightening has obvious effect；And administration group rat is able to maintain that normal physiological function, the normal growth of rat is not produced not Good influence.
2) the tailored version clinical nutrition that the present invention is provided is formulated the influence to male rat reproductive function.
Wistar male rats 96 are taken, the modeling of sterility is carried out to male rat with gossypol.Experimental animal is divided at random Into totally 8 groups of Normal group, model group, administration group 1, administration group 2, administration group 3, administration group 4, administration group 5, administration group 6, administration Group 1,2,3,4 distinguishes the nutrient formulation that stomach raises embodiment 1,2,3,4, and the difference stomach of administration group 5,6 raises comparative example 1, comparative example 2.Often Each 12 of animal of group, counts 3 months.Male female mice was administered after 5 weeks by 1:2 ratio carries out the 1st wheel and mated, and separately equal proportion is changed after 1 week Female mice carry out the 2nd wheel mate.Female mice after mating is dissected after 1 week, observes its become pregnant number and tire mouse number, male mouse is judged with this Fertility.The dead male mouse in experiment periods end, determines testicular weight, takes histotomy to make histopathological examination, observe sperm shape State, energy, calculate sperm number, activity ratio, take average for comparing.
The tailored version clinical nutrition of table 2 is formulated the influence to male rat reproductive function
Group Testis weight in wet base (mg)/body weight (g)
Administration group 1 6.43±0.64
Administration group 2 6.73±0.53
Administration group 3 6.33±0.59
Administration group 4 6.39±0.66
Administration group 5 5.57±0.62
Administration group 6 5.32±0.39
Control group 6.12±0.46
Model group 3.45±0.55
Table 2 understands that administration group 1,2,3,4,5,6 is compared with model group, P ＜ 0.05, illustrates administration group rat testicle weight in wet base (P ＜ 0.05) is increased significantly compared with gossypol model group animal with body weight ratio, and the developmental condition of Testicular Seminiferous Epithelium substantially enters Step.Administration group 1,2,3,4 is compared with administration group 5,6, P ＜ 0.05, illustrates the rat testicle weight in wet base of administration group 1,2,3,4 and weight ratio Value is increased significantly (P ＜ 0.05) compared with administration group 5,6 animals, and the developmental condition of Testicular Seminiferous Epithelium substantially improves, research knot Fruit shows that tailored version clinical nutrition formula has obvious facilitation to male rat reproductive function.
From above-described embodiment, various components mutually match in the special clinical nutrition formula of male sterility of the present invention Close, reasonable, comprehensive nutritional support is provided for male sterility patient, to improve the bad shape of nutritional status potential and having occurred State, while kidney tonifying, invigorating the spleen, soothing the liver integration of drinking and medicinal herbs composition, natural plants compound and new resource food are added, to improve male The condition of sterile person, promotes production of sperm ability, improves sperm motility.
The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and to replace In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and repaiied Change, all should be contained within the scope of the invention.

Claims (9)

1. a kind of male sterility tailored version clinical nutrition formula, it is characterised in that including following component and its parts by weight：15- 40 parts of protein, 2-8 parts of fat, 40-55 parts of carbohydrate, 5.8-8 parts of dietary fibers, 0.6-1.2 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 0.05-1 parts Meals elite, 0.1-2 parts of integration of drinking and medicinal herbs compositions, 0.1-3 parts of natural plants compounds and 0.005-5 parts of new resource foods；
Wherein, the integration of drinking and medicinal herbs composition in Poria cocos, raspberry, matrimony vine, Chinese yam, spina date seed, oyster, radix glycyrrhizae at least one Kind；
Wherein, the new resource food be selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, In CPP, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii, xylo-oligosaccharide at least It is a kind of.
2. a kind of male sterility tailored version clinical nutrition formula according to claim 1, it is characterised in that the natural plant Compounds are selected from l-cn, Glucosamine, FOS, lutein, phytosterol, lycopene, resveratrol, big At least one of allicin.
3. a kind of male sterility tailored version clinical nutrition formula according to claim 1, it is characterised in that the medicine food is same The parts by weight of each component are as follows in derived components：0-1 parts of Poria cocos, 0-1 parts of raspberry, 0-1 parts of matrimony vine, 0-1 parts of Chinese yam, spina date seed 0-1 parts, 0-1 parts of oyster.
4. a kind of male sterility tailored version clinical nutrition formula according to claim 1, it is characterised in that the protein The good protein weight of middle offer accounts for more than the 70% of gross protein weight.
5. a kind of male sterility tailored version clinical nutrition formula according to claim 1, it is characterised in that the male is not Educate n-6 aliphatic acid in tailored version clinical nutrition formula：N-3 aliphatic acid=3~4:1.
6. a kind of male sterility tailored version clinical nutrition formula according to claim 1, it is characterised in that the water solubility Ascorbic parts by weight are 0.102 part in vitamin.
7. a kind of male sterility tailored version clinical nutrition formula according to claim 1, it is characterised in that the micro member The parts by weight of element zinc are 0.016 part in element.
8. a kind of preparation method of male sterility tailored version clinical nutrition formula as claimed in claim 1, it is characterised in that institute State fat, liposoluble vitamin, water soluble vitamin be respectively adopted micro-capsule embedding techniques be made it is powdered, the integration of drinking and medicinal herbs into Point by crush, decoct, be spray-dried and sieve be made it is powdered.
9. preparation method according to claim 8, it is characterised in that the fat, liposoluble vitamin, water soluble vitamin life The mesh number that element and integration of drinking and medicinal herbs composition sieve is 60-80 mesh.
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CN108703364A (en) * 2018-05-10 2018-10-26 上海奥医生物医药科技有限公司 Treating fatty acid metabolism tailored version clinical nutrition formula and preparation method thereof
CN108703365A (en) * 2018-05-10 2018-10-26 上海奥医生物医药科技有限公司 Protein allergy tailored version clinical nutrition formula and preparation method thereof
CN108685865A (en) * 2018-07-27 2018-10-23 东莞广易中医学研究中心（有限合伙） Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function
CN109007857A (en) * 2018-08-29 2018-12-18 苏州佩普肽康生物科技有限公司 Improve the food formula of special diet and preparation method thereof of mankind spermatozoon quality
CN109497563A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 Leucoderma tailored version clinical nutrition formula and preparation method thereof
CN109172804A (en) * 2018-11-22 2019-01-11 量子高科(中国)生物股份有限公司 It is a kind of to improve spermatozoon activity, improving infertile composition and preparation method thereof
CN110507808A (en) * 2019-08-29 2019-11-29 山东福德特医生物工程有限公司 A kind of composition and preparation method thereof improving mankind spermatozoon quality and weak defective ejaculation essence
CN112244288A (en) * 2020-10-22 2021-01-22 山东哈维药业有限公司 Compound protein nutrient for male pregnancy preparation and preparation method thereof
EP4256977A1 (en) * 2022-04-06 2023-10-11 The Ceutics Company GesmbH Improving semen quality
WO2023194470A1 (en) 2022-04-06 2023-10-12 The Ceutics Company Gesmbh Improving semen quality
WO2024170665A1 (en) * 2023-02-17 2024-08-22 Lo.Li. Pharma S.R.L. Composition for the use in the treatment of polycystic ovary syndrome

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Application publication date: 20171013