CN108685865A - Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function - Google Patents

Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function Download PDF

Info

Publication number
CN108685865A
CN108685865A CN201810843416.8A CN201810843416A CN108685865A CN 108685865 A CN108685865 A CN 108685865A CN 201810843416 A CN201810843416 A CN 201810843416A CN 108685865 A CN108685865 A CN 108685865A
Authority
CN
China
Prior art keywords
parts
powder
drinking
integration
medicinal herbs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810843416.8A
Other languages
Chinese (zh)
Inventor
李自明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dongguan Guangyi Research Center Of Traditional Chinese Medicine (limited Partnership)
Original Assignee
Dongguan Guangyi Research Center Of Traditional Chinese Medicine (limited Partnership)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dongguan Guangyi Research Center Of Traditional Chinese Medicine (limited Partnership) filed Critical Dongguan Guangyi Research Center Of Traditional Chinese Medicine (limited Partnership)
Priority to CN201810843416.8A priority Critical patent/CN108685865A/en
Publication of CN108685865A publication Critical patent/CN108685865A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/60Fish, e.g. seahorses; Fish eggs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487Psoralea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/746Morinda
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a kind of integration of drinking and medicinal herbs improving male's immune function to chew tabletting and preparation method thereof, major ingredient is integration of drinking and medicinal herbs, the each component of following parts by weight, ostreae testa pulverata, loach powder, yolk powder, danshen powder, Psoralen cosmetics, medlar powder, Morinda officinalis, Radix Angelicae Sinensis, Cortex Phellodendri and Fructus Corni;The auxiliary material is the mixture that xylitol, maltodextrin, vegetable fat powder, magnesium stearate, palm oil and vegetable oil are formed according to arbitrary proportion.The present invention is good in taste, and preparation method simple possible can be widely popularized.Effect is apparent, with strong points, has no effect for blood pressure, blood glucose and blood fat, conveniently takes, and convenient for preserving, preparation method is simple.

Description

Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function
Technical field
The present invention relates to a kind of integration of drinking and medicinal herbs improving male's immune function to chew tabletting and preparation method thereof.
Background technology
Male sterility refers to that Mr. and Mrs live together 1 year or more after marriage, there is the sexual life of normal rule, does not use contraceptives, The wife's side caused by the reason of the bridegroom's or husband's side cannot become pregnant, or can become pregnant cannot pregnant, childbirth.Male sterility itself is more than a kind of only The disease of vertical property, but as caused by various diseases, a variety of pathogenic factors.With the development of the social economy, modern science and technology is prominent Fly to push ahead vigorously, the exacerbation of global pollution, worse and worse, this phenomenon have to let us self-examination for the fecundity of the mankind.There is money Material shows that the sterile rate of the current couple at child-bearing age has reached 15% or more, and the ratio of men and women's reason is almost the same.The disease cause of disease The interpretation of the cause, onset and process of an illness can be attributed to positive unsaturated vapor, be given birth in perverse trend;Intemperance in sexual life, kidney essense consume;Perverse trend stasis blocking, essence is solidifying not to be dissipated;Unhygienic diet, Smart room is upset in damp and hot interior life;Depressed emotion then functional activity of QI being not smooth;Knot in wound extravasated blood, the interior knot of extravasated blood, mechanism of qi retardance.Modern medicine Research finds that male's immunity declines, and AsAb is to cause sperm to enter blood circulation by many factors, and sperm is as same Kind alloantigen, stimulates body, and immune response occurs, produces AsAb.AsAb mainly causes agglutination of spermatozoa And braking, it causes sperm motility, motility rate to decline, causes infertility, become problem and common disease factor in male sterility.At present should The modern treatment means of disease are mainly hormone therapy, and clinical effectiveness is not highly desirable, and side effect is very big.Traditional Chinese medicine Treatment provide more wide foreground for the treatment of this situation.Therefore, the improvement male's immune having no toxic side effect is researched and developed The integration of drinking and medicinal herbs of function chews tabletting, and the product conveniently taken is highly desirable.
The product for improving the traditional Chinese medicine ingredients of male's sexual on the market now is relatively more, but is mostly used kidney tonifying, enriching yin on the market Etc. plurality of Chinese composition, or containing a variety of Chinese medicine composition composition such as Radix Salviae Miltiorrhizae, psoralea corylifolia, the fruit of Chinese wolfberry, Morinda officinalis and Fructus Corni, Most of is that capsule, tablet or electuary dosage form functionally often exist although having certain curative effect on improving sexual function Using for nourishing is relatively strong, only has the function of the effect of improvement impotence/either premature ejaculation or production of sperm, for immune function Without directly affecting, often there is certain skewed popularity in nourishing class Chinese medicine, directly transfer the energy of body, and effect is relatively not complete enough Face, the adverse reactions such as cause dry, physical demands big, pharmacological property is not gentle enough, and there is potentially to the wind of hepatic and renal function loss Danger, although and be all integration of drinking and medicinal herbs ingredient, curative effect is fine, there are the mixing of a variety of help class Chinese medicines, capsule, tablet or Many drawbacks such as that electuary is taken is inconvenient, cannot protect privacy.We are on the basis of summarizing long-term clinical experience, for city Field demand, increases auxiliary material on the basis of the Chinese medicine and food ingredients of the above-mentioned integration of drinking and medicinal herbs for having obvious curative effects -- the systems such as xylitol At masticable tabletting, auxiliary material does not influence blood fat and blood glucose so that carries and take more convenient and market popularization value.
Invention content
To overcome the deficiencies of existing technologies, the present invention provides a kind of integration of drinking and medicinal herbs chewing tabletting improving male's immune function And preparation method thereof,
The technical scheme is that:
A kind of integration of drinking and medicinal herbs chewing tabletting improving male's immune function, including major ingredient and auxiliary material, the major ingredient are that medicine food is same Source, accounts for the 90% of stagnation pressure sheet weight, each component of following parts by weight, 2-4 parts of ostreae testa pulverata, 2-4 parts of loach powder, 2-4 parts of yolk powder, 2-4 parts of danshen powder, 1-3 parts of Psoralen cosmetics, 2-4 parts of medlar powder, 2-4 parts of Morinda officinalis, 2-4 parts of Radix Angelicae Sinensis, 2-4 parts of Cortex Phellodendri and mountain Zhu 2-4 parts of cornel;The auxiliary material is 0.5-0.7 parts of xylitol, 0.1-0.2 parts of maltodextrin, 0.1-0.2 parts of vegetable fat powder, stearic acid The mixture 0.2-0.4ml that 0.01-0.02 parts of magnesium, palm oil and vegetable oil are formed according to arbitrary proportion.
3 parts of the ostreae testa pulverata, 3 parts of loach powder, 3 parts of yolk powder, 3 parts of danshen powder, 3 parts of Psoralen cosmetics, medlar powder 3 3 parts of part, 3 parts of Morinda officinalis, 3 parts of Radix Angelicae Sinensis, 3 parts of Cortex Phellodendri and Fructus Corni;0.6 portion of the xylitol, plants fat at 0.2 part of maltodextrin The mixture 0.2ml that 0.2 part of end, 0.01 part of magnesium stearate, palm oil and vegetable oil are formed according to arbitrary proportion.
A method of preparing improves the integration of drinking and medicinal herbs chewing tabletting of male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 800~1000 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 50-70 DEG C, and pellet moisture 0.5%, when compression molding controls ambient humidity, relative humidity 60% Below;
(6)Packaging:Packaging can obtain after sterilizing.
It is an advantage of the invention that:
The collective effect of each component of the application makes the present invention with more obviously raising mankind spermatozoon quality and improves immune work( The effect of energy.The present invention is good in taste, and preparation method simple possible can be widely popularized.Effect is apparent, with strong points, for blood Pressure, blood glucose and blood fat have no effect, and conveniently take, and convenient for preserving, preparation method is simple.
Specific implementation mode
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and It is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.People in the art Member it should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and form into Row modifications or substitutions, but these modifications and replacement are each fallen in protection scope of the present invention.
Embodiment 1:The present invention relates to the integration of drinking and medicinal herbs of a kind of improvement mankind spermatozoon quality and immune function to chew tabletting, packet Major ingredient and auxiliary material are included, the major ingredient is each component of following parts by weight, and the major ingredient is integration of drinking and medicinal herbs, accounts for stagnation pressure sheet weight 90%, each component of following parts by weight, ostreae testa pulverata 2g, loach powder 2g, yolk powder 2g, danshen powder 2g, Psoralen cosmetics 1g, matrimony vine Sub- powder 2g, Morinda officinalis 2g, Radix Angelicae Sinensis 2g, Cortex Phellodendri 2g and Fructus Corni 2g;The auxiliary material be xylitol 0.5g, maltodextrin 0.1g, The mixture that vegetable fat powder 0.1g, magnesium stearate 0.01g, 0.2ml palm oil and vegetable oil are formed according to arbitrary proportion.
The method of the integration of drinking and medicinal herbs chewing tabletting of the improvement male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 800 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 50 DEG C, pellet moisture 0.5%, and when compression molding controls ambient humidity, relative humidity be 60% with Under;
(6)Packaging:Packaging can obtain after sterilizing.
Embodiment 2:The present invention relates to the integration of drinking and medicinal herbs of a kind of improvement mankind spermatozoon quality and immune function to chew tabletting, including master Material and auxiliary material, the major ingredient are each component of following parts by weight, and the major ingredient is integration of drinking and medicinal herbs, accounts for stagnation pressure sheet weight 90%, each component of following parts by weight, the ostreae testa pulverata 3g, loach powder 3g, yolk powder 3g, danshen powder 3g, Psoralen cosmetics 3g, Medlar powder 3g, Morinda officinalis 3g, Radix Angelicae Sinensis 3g, Cortex Phellodendri 3g and Fructus Corni 3g;The xylitol 0.6g, it maltodextrin 0.2g, plants The mixture 0.2ml that fat end 0.2g, magnesium stearate 0.01g, palm oil and vegetable oil are formed according to arbitrary proportion.
A method of preparing improves the integration of drinking and medicinal herbs chewing tabletting of male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 900 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 60 DEG C, pellet moisture 0.5%, and when compression molding controls ambient humidity, relative humidity be 60% with Under;
(6)Packaging:Packaging can obtain after sterilizing.
Embodiment 3:A kind of integration of drinking and medicinal herbs chewing tabletting improving male's immune function, including major ingredient and auxiliary material, it is described Major ingredient is integration of drinking and medicinal herbs, accounts for the 90% of stagnation pressure sheet weight, each component of following parts by weight, ostreae testa pulverata 4g, loach powder 4g, yolk powder 4g, danshen powder 4g, Psoralen cosmetics 3g, medlar powder 4g, Morinda officinalis 4g, Radix Angelicae Sinensis 4g, Cortex Phellodendri 4g and Fructus Corni 4g, the auxiliary material It is xylitol 0.7g, maltodextrin 0.2g, vegetable fat powder 0.2g, magnesium stearate 0.02g, palm oil and vegetable oil according to arbitrary proportion The mixture 0.3ml of composition.
A method of preparing improves the integration of drinking and medicinal herbs chewing tabletting of male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 1000 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 70 DEG C, pellet moisture 0.5%, and when compression molding controls ambient humidity, relative humidity be 60% with Under;
(6)Packaging:Packaging can obtain after sterilizing.
[Experimental result]
General information
1. choosing in October, 2017 in May, 2018,61 patients for meeting the sterility that Chinese medical discrimination is damage of kidney-YIN card press It is grouped at random according to medical sequencing, if observation group, that is, takes this product group, control group, i.e. capsule for promoting semen generation group.Patients with infertility Using random digits table, it is divided into observation group and control group.Wherein observation group 31,50.50 years old ± 5.0 years old age.Control Group 30, male 14,53.40 years old ± 4.60 years old age.Two groups of Baseline Datas are comparable.
2. diagnostic criteria Western medicine diagnostic criteria, with reference to WHO's"Human seminal fluid and Mucus interaction experiment Room inspection manual"Sorting technique Criteria Inclusion Bing Ren &#91;5&#93;:Man and wife 1 year after marriage, regular sexual life is not practised contraception, the wife's side Non-reproductive system, cardiovascular system, internal system, urinary system, nervous system etc. and the relevant systemic disease of fertility, Medical history without female infertility but because of husband reason unpregnancy person;Sperm recovery:It is 3~7 days ascetic, masturbation method or electronic It takes smart method to take essence, passes through computer automatic analysis network analysis:< 20 × 1060-5 × 10 /ml sperm concentration >6/ml;It is living Rate < 60%;A+b grades of sperm motility < 50%;Or the patient of a grades of sperm motility < 25% is selected.
3, therapy and the course for the treatment of
Oral this product is given by observation group, and control group takes osmanthus medicine capsule for promoting semen generation(Osmanthus medicine word Z01060147):Osmanthus medicine production of sperm glue The key agents of capsule form:The fruit of glossy privet, Radix Codonopsis, the fruit of Chinese wolfberry, asparagus fern, Radix Ophiopogonis, plantain seed, Semen Cuscutae, mulberries, raspberry, Huang Stilbene, red ginseng, safflower etc. belong to Chinese patent medicine formula preparation, are produced by Guangxi pharmaceutical factory of attached Rui Kang hospitals of Chinese medicine university, observation combination The usage of control group:3 tablets each time, 3 times a day, 3 months courses for the treatment of, totally 2 courses for the treatment of, warm water delivery service, postprandial half an hour. Half an hour warm water delivery service after meal, 3 months courses for the treatment of, totally 2 courses for the treatment of, while being practised contraception using sheath.
4, curative effect MAIN OUTCOME MEASURES
(1)Serum antisperm antibody inspection:Reagent is purchased from Shenzhen Huakang Biology Medical Engineering Co., Ltd and assists to check, mainly Use ELISA method;(2)Sperm recovery:Sperm recovery(Ascetic 3-7 days, masturbation method, can not masturbator can be electronic Take essence), control laboratory inspection is sent after making a collection of specimens immediately, inspection is assisted by the attached Dongguan stone row hospital laboratory of Guangdong medical university It looks into, using computer-assisted semen analysis(Beijing mighty force sperm quality detecting system software)It measures.Measuring main project has:Essence Liquid measure, pH value, liquefying time, a grade sperm, b grades of sperms, c grades of sperms, a+b grades of sperms, sperm concentration, rate of teratosperms etc.. (3))General curative effect evaluation criteria is with reference to health ministry"New Chinese medicine guideline of clinical investigations"&#91;6&#93;And WHO"Infertility The inspection of Mr. and Mrs' standard and diagnosis handbook", two groups respectively carry out semen efamination as required at the end of pretherapy and post-treatment and each course for the treatment of, Take the average value of 3 results.1. clinical cure:Sperm concentration, motility rate, vitality restoration are normal and the wife's side is pregnant;2. effective:Sperm Density, motility rate, vitality restoration are normal;3. effectively:Sperm concentration, motility rate, vitality restoration promote 30% < 60% of >;4. invalid:Essence Sub- density, motility rate, vitality restoration are unchanged after promoting < 30% or treating.
As a result:
1, after treatment in 6 months, 15 people of observation group's clinical cure, effective 4 people, effective 5 people, invalid 8 People, gross efficiency 75%;16 people of control group clinical cure, effective 4 people, effective 5 people, invalid 7 people, gross efficiency are 76%;;Ridit analyzes two groups and compares P>0.05, no significant difference.Illustrate that this product and pure Chinese medicine capsule for promoting semen generation are being treated Curative effect indifference in terms of male immune infertility, and almost without side effect.
2, to the influence of immune function:Two groups of interleukin 2s, Serum Levers of Soluble Interleukin 2 Receptor and neoplasm necrosis The factor only comparision contents, the concentration of interleukin 2 and Serum Levers of Soluble Interleukin 2 Receptor in the serum of this product observation group Significantly rise and decline, with experimental group take before compared with the significant (P&lt of difference;0.05).And the front and back leucocyte of control group experiment Interleukin -2 and the concentration of Serum Levers of Soluble Interleukin 2 Receptor change without conspicuousness.Experimental group and the pretherapy and post-treatment serum of control group The concentration of tumor necrosis factor instrument is without significant changes.
3, the case where two groups of pretherapy and post-treatment sperm concentrations, motility rate, vigor check:Sperm recovery before observation group's treatment As a result:A grades:12.5 ± 6.28, a+b grades:36.25 ± 5.92, sperm motility rate:49.44 ± 7.37, sperm concentration:15.06 ±3.51;Sperm recovery result before control group treatment:A grades:20 ± 11.13, a+b grades:36.40 ± 5.46, essence Sub- motility rate:51.57±4.33 ;Sperm concentration:13.37±3.47;Two groups of comparisons:A grades:T=- 0.960,15 P= 0.337;A+b grades:T=- 0.120, P=0.904;Motility rate:T=- 1.635, P=0.102;Density:T=- 1.914, P =0.056。
P ﹥ 0.05 are compared before two groups of treatments, two groups are compared no significant difference before treatment, are comparable.Observation group controls After treatment:A grades:24.03±5.62;A+b grades:52.47±8.95:Motility rate:66.16 ±8.21;Density 32.47 ± 12.62.Control group:A grades of sperms:26.53 ± 8.31, a+b grades of sperms:54.47 ± 6.89, sperm motility rate:65.87± 6.23 sperm concentration:30.20±5.73;Two groups of comparisons after treatment:It is compared after a grades:P>0.05, significant difference has statistics Meaning illustrates that observation group is consistent with effect after control group treatment.I.e. product and osmanthus medicine capsule for promoting semen generation group are in treatment male immune It is identical in terms of sperm quality in terms of sterility, illustrate this product other than treating oligospermatism, for immunocyte decline The treatment of male sterility be also ideal and convenient product, can promote and apply.
The application is added to the special food materials that immune function is generated and promoted simultaneously for mankind spermatozoon and has help liver The integration of drinking and medicinal herbs ingredient of renal function, and make dosage form into chewing tabletting, it is easy to use and immune with specific reference to patient's self-assessment Function status is come the dosage form that adjusts and takes mode.Wherein main component:Oyster is marine organisms with high nutritive value, research It was found that oyster there are a variety of desirable influences to ridicule the function of human body.Experiment display, body can be significantly improved after taking ostreae testa pulverata The level of interleukin 2 reduces the level of soluble il- -2, illustrates that ostreae testa pulverata can make the immunization machine of body It can keep stablizing.Interleukin 2 is mainly generated by the TH cells activated.TH cells are in interleukin 1 and other signals Co stituation under just secreting leukocytes mesonium -2 4-12 h, the interleukin 2 receptor of interleukin 2 and high affinity In conjunction with by T cell to interleukin 2 and its receptor complex progress pinocytosis, to make T cell activation.Thus, it is white thin The generation of the interleukin 2 receptor on born of the same parents' interleukin -2 and T cell surface is the important symbol of T cell activation.T cell was both secreted Interleukin 2, and there is interleukin 2 receptor, it is formed the positive feedback amplification of autocrine activation amplification, makes to be lived The T cell of change clones to obtain rapid amplifying activation.Thus it is generally acknowledged that interleukin 2 and its receptor are the bases of t cell response Plinth.Il-2 Level height shows T cell high activity.Interleukin 2 receptor mediates immune in interleukin 2 It plays an important role in reaction, Serum Levers of Soluble Interleukin 2 Receptor is a kind of important immunosuppressive substance of body.As T is thin Born of the same parents are activated, and T cell largely generates interleukin 2 and expresses interleukin 2 receptor, interleukin 2 and leucocyte Jie's plain-2 acceptor results in more T cell activations again after combining, hence into the cycle of positive feedback.It is solvable in the process Property interleukin 2 receptor can be combined with interleukin 2, inhibit the leucocyte on interleukin 2 and T cell surface to be situated between Plain-2 acceptor combine, therefore can neutralize activity of interleukin-2 solubility from cytokine -2 receptor to interleukin 2 Generation provide constraints, and by interleukin 2 dependent response inhibit the immune system being likely to occur it is excessive swash It is living.Serum Levers of Soluble Interleukin 2 Receptor is closely related with interleukin 2, and generation all relies on T cell activation, white thin Born of the same parents' interleukin -2 activates T cell to be allowed to generate cell membrane interleukin-2 receptor, is to generate Serum Levers of Soluble Interleukin 2 Receptor Prerequisite, and Serum Levers of Soluble Interleukin 2 Receptor play immunoregulation effect be also by -2 work(of blocking leukocyte interleukin Can mode, therefore in the immune system of body understand Serum Levers of Soluble Interleukin 2 Receptor and interleukin 2 level And variation, it is vital to holding the entire immune functional state of male.Japan medical science researcher observes male sterility 1000, it is found that Zn content is insufficient in the sperm of 37 people.Trace element zinc can promote the energy of sperm, and sperm can be prevented too early Disintegrate, is conducive to be combined with ovum, it is seen that zinc has significant impact to fertility.Oyster, the loach of more foods rich in zinc etc. is for improving essence Protonatomic mass has certain effect.

Claims (3)

1. a kind of integration of drinking and medicinal herbs improving male's immune function chews tabletting, which is characterized in that described including major ingredient and auxiliary material Major ingredient is integration of drinking and medicinal herbs, accounts for the 90% of stagnation pressure sheet weight, each component of following parts by weight, 2-4 parts of ostreae testa pulverata, 2-4 parts of loach powder, 2-4 parts of yolk powder, 2-4 parts of danshen powder, 1-3 parts of Psoralen cosmetics, 2-4 parts of medlar powder, 2-4 parts of Morinda officinalis, 2-4 parts of Radix Angelicae Sinensis, Huang 2-4 parts of 2-4 parts of cypress and Fructus Corni;The auxiliary material is 0.5-0.7 parts of xylitol, 0.1-0.2 parts of maltodextrin, vegetable fat powder 0.1- The mixture 0.2-0.4ml that 0.2 part, 0.01-0.02 parts of magnesium stearate, palm oil and vegetable oil are formed according to arbitrary proportion.
2. a kind of integration of drinking and medicinal herbs improving male's immune function according to claim 1 chews tabletting, which is characterized in that institute 3 parts of the ostreae testa pulverata stated, 3 parts of loach powder, 3 parts of yolk powder, 3 parts of danshen powder, 3 parts of Psoralen cosmetics, 3 parts of medlar powder, Morinda officinalis 3 3 parts of part, 3 parts of Radix Angelicae Sinensis, 3 parts of Cortex Phellodendri and Fructus Corni;It is 0.6 part of the xylitol, 0.2 part of maltodextrin, 0.2 part of vegetable fat powder, hard The mixture 0.2ml that 0.01 part of fatty acid magnesium, palm oil and vegetable oil are formed according to arbitrary proportion.
3. a kind of method preparing the integration of drinking and medicinal herbs chewing tabletting as claimed in claim 1 or 2 for improving male's immune function, special Sign is, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 800~1000 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 50-70 DEG C, and pellet moisture 0.5%, when compression molding controls ambient humidity, relative humidity 60% Below;
(6)Packaging:Packaging can obtain after sterilizing.
CN201810843416.8A 2018-07-27 2018-07-27 Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function Pending CN108685865A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810843416.8A CN108685865A (en) 2018-07-27 2018-07-27 Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810843416.8A CN108685865A (en) 2018-07-27 2018-07-27 Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function

Publications (1)

Publication Number Publication Date
CN108685865A true CN108685865A (en) 2018-10-23

Family

ID=63850937

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810843416.8A Pending CN108685865A (en) 2018-07-27 2018-07-27 Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function

Country Status (1)

Country Link
CN (1) CN108685865A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101019989A (en) * 2007-03-06 2007-08-22 王二丰 Kidney invigorating and Yang strengthening Chinese medicine prepn
CN101239121A (en) * 2008-03-25 2008-08-13 张文芳 Oral preparation for promoting ovulation and preparation thereof
CN103110813A (en) * 2013-01-30 2013-05-22 贵州联盛药业有限公司 Medicament for tonifying kidney and producing sperm and preparation method thereof
CN103585422A (en) * 2013-11-20 2014-02-19 潘恒晔 A Chinese medicinal composition for treating male infertility, and its preparation method
CN107242550A (en) * 2017-06-29 2017-10-13 上海复旦奥医医学科技有限公司 A kind of male sterility tailored version clinical nutrition formula and preparation method thereof
CN107296949A (en) * 2017-07-13 2017-10-27 山东仁迪生物工程集团有限公司 Integration of drinking and medicinal herbs compound formulation and its preparation method and application

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101019989A (en) * 2007-03-06 2007-08-22 王二丰 Kidney invigorating and Yang strengthening Chinese medicine prepn
CN101239121A (en) * 2008-03-25 2008-08-13 张文芳 Oral preparation for promoting ovulation and preparation thereof
CN103110813A (en) * 2013-01-30 2013-05-22 贵州联盛药业有限公司 Medicament for tonifying kidney and producing sperm and preparation method thereof
CN103585422A (en) * 2013-11-20 2014-02-19 潘恒晔 A Chinese medicinal composition for treating male infertility, and its preparation method
CN107242550A (en) * 2017-06-29 2017-10-13 上海复旦奥医医学科技有限公司 A kind of male sterility tailored version clinical nutrition formula and preparation method thereof
CN107296949A (en) * 2017-07-13 2017-10-27 山东仁迪生物工程集团有限公司 Integration of drinking and medicinal herbs compound formulation and its preparation method and application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
(美)JENS T.CARSTENSEN, 中国医药科技出版社 *

Similar Documents

Publication Publication Date Title
CN101002847B (en) Medicine for treating mazoplasia, and its preparing method
CN103830577B (en) A kind of medical composition and its use treating hepatobiliary calculus and urinary stone disease
CN101288729A (en) Chinese medicine granule for treating various dysmenorrhea
CN102240318A (en) Traditional Chinese medicine for tonifying qi and increasing breast milk
CN109528980B (en) Traditional Chinese medicine composition for treating ovarian reserve function decline disease and pharmaceutical application thereof
CN103735937B (en) There is the medicine and health products promoting ferrous components to absorb and to enrich blood
CN103585479A (en) Blood-replenishing pill and blood-replenishing capsule for treating iron-deficiency anemia
CN101708306B (en) Chinese medicinal composition for treating gastropathy and preparation method thereof
CN102423335B (en) Medicine combination for treating impotence and premature ejaculation and preparation method thereof
CN106420955A (en) Traditional Chinese medicine composition with blood glucose reduction assistance effect, preparation method and product of traditional Chinese medicine composition
CN105943651A (en) Traditional Chinese medicine composition for treating premature ovarian failure, and application thereof
CN102652774B (en) Drug composition for treating leukopenia and hypoimmunity caused by chemoradiotherapy and preparation method and quality detection method
CN105944020B (en) Traditional Chinese medicine for treating ovarian function decline
CN104043042A (en) Traditional Chinese medicine composition for treating hepatic calculus
CN108685865A (en) Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male&#39;s immune function
CN101590157B (en) Chinese medicinal preparation for treating embryo diapause
CN103330721A (en) Holothurian flower extract for treatment of female POF and its preparation method
CN101129492B (en) Traditional Chinese medicine formulated product for treating melancholia
CN103191399A (en) Traditional Chinese medicine composition for treating bronchial asthma in acute-outbreak period
CN102861159A (en) Medicine composition for treating dysmenorrheal as well as preparation method and application thereof
CN103520646B (en) Chinese medicine composition for treating depression and preparation method of Chinese medicine composition
CN104645297A (en) Traditional Chinese medicine composition for warming uterus to promote gestation and preparation method of preparation thereof
CN103585583A (en) Traditional Chinese medicine composition for treating hepatic calculus and application thereof
CN104906194B (en) A kind of medicinal plaster treating asthma and preparation technology and determination method
CN108635483A (en) A kind of Chinese medicinal formulae for treating hypoovarianism

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination