CN108685865A - Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function - Google Patents
Improve the integration of drinking and medicinal herbs chewing tabletting and preparation method thereof of male's immune function Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention relates to a kind of integration of drinking and medicinal herbs improving male's immune function to chew tabletting and preparation method thereof, major ingredient is integration of drinking and medicinal herbs, the each component of following parts by weight, ostreae testa pulverata, loach powder, yolk powder, danshen powder, Psoralen cosmetics, medlar powder, Morinda officinalis, Radix Angelicae Sinensis, Cortex Phellodendri and Fructus Corni;The auxiliary material is the mixture that xylitol, maltodextrin, vegetable fat powder, magnesium stearate, palm oil and vegetable oil are formed according to arbitrary proportion.The present invention is good in taste, and preparation method simple possible can be widely popularized.Effect is apparent, with strong points, has no effect for blood pressure, blood glucose and blood fat, conveniently takes, and convenient for preserving, preparation method is simple.
Description
Technical field
The present invention relates to a kind of integration of drinking and medicinal herbs improving male's immune function to chew tabletting and preparation method thereof.
Background technology
Male sterility refers to that Mr. and Mrs live together 1 year or more after marriage, there is the sexual life of normal rule, does not use contraceptives,
The wife's side caused by the reason of the bridegroom's or husband's side cannot become pregnant, or can become pregnant cannot pregnant, childbirth.Male sterility itself is more than a kind of only
The disease of vertical property, but as caused by various diseases, a variety of pathogenic factors.With the development of the social economy, modern science and technology is prominent
Fly to push ahead vigorously, the exacerbation of global pollution, worse and worse, this phenomenon have to let us self-examination for the fecundity of the mankind.There is money
Material shows that the sterile rate of the current couple at child-bearing age has reached 15% or more, and the ratio of men and women's reason is almost the same.The disease cause of disease
The interpretation of the cause, onset and process of an illness can be attributed to positive unsaturated vapor, be given birth in perverse trend;Intemperance in sexual life, kidney essense consume;Perverse trend stasis blocking, essence is solidifying not to be dissipated;Unhygienic diet,
Smart room is upset in damp and hot interior life;Depressed emotion then functional activity of QI being not smooth;Knot in wound extravasated blood, the interior knot of extravasated blood, mechanism of qi retardance.Modern medicine
Research finds that male's immunity declines, and AsAb is to cause sperm to enter blood circulation by many factors, and sperm is as same
Kind alloantigen, stimulates body, and immune response occurs, produces AsAb.AsAb mainly causes agglutination of spermatozoa
And braking, it causes sperm motility, motility rate to decline, causes infertility, become problem and common disease factor in male sterility.At present should
The modern treatment means of disease are mainly hormone therapy, and clinical effectiveness is not highly desirable, and side effect is very big.Traditional Chinese medicine
Treatment provide more wide foreground for the treatment of this situation.Therefore, the improvement male's immune having no toxic side effect is researched and developed
The integration of drinking and medicinal herbs of function chews tabletting, and the product conveniently taken is highly desirable.
The product for improving the traditional Chinese medicine ingredients of male's sexual on the market now is relatively more, but is mostly used kidney tonifying, enriching yin on the market
Etc. plurality of Chinese composition, or containing a variety of Chinese medicine composition composition such as Radix Salviae Miltiorrhizae, psoralea corylifolia, the fruit of Chinese wolfberry, Morinda officinalis and Fructus Corni,
Most of is that capsule, tablet or electuary dosage form functionally often exist although having certain curative effect on improving sexual function
Using for nourishing is relatively strong, only has the function of the effect of improvement impotence/either premature ejaculation or production of sperm, for immune function
Without directly affecting, often there is certain skewed popularity in nourishing class Chinese medicine, directly transfer the energy of body, and effect is relatively not complete enough
Face, the adverse reactions such as cause dry, physical demands big, pharmacological property is not gentle enough, and there is potentially to the wind of hepatic and renal function loss
Danger, although and be all integration of drinking and medicinal herbs ingredient, curative effect is fine, there are the mixing of a variety of help class Chinese medicines, capsule, tablet or
Many drawbacks such as that electuary is taken is inconvenient, cannot protect privacy.We are on the basis of summarizing long-term clinical experience, for city
Field demand, increases auxiliary material on the basis of the Chinese medicine and food ingredients of the above-mentioned integration of drinking and medicinal herbs for having obvious curative effects -- the systems such as xylitol
At masticable tabletting, auxiliary material does not influence blood fat and blood glucose so that carries and take more convenient and market popularization value.
Invention content
To overcome the deficiencies of existing technologies, the present invention provides a kind of integration of drinking and medicinal herbs chewing tabletting improving male's immune function
And preparation method thereof,
The technical scheme is that:
A kind of integration of drinking and medicinal herbs chewing tabletting improving male's immune function, including major ingredient and auxiliary material, the major ingredient are that medicine food is same
Source, accounts for the 90% of stagnation pressure sheet weight, each component of following parts by weight, 2-4 parts of ostreae testa pulverata, 2-4 parts of loach powder, 2-4 parts of yolk powder,
2-4 parts of danshen powder, 1-3 parts of Psoralen cosmetics, 2-4 parts of medlar powder, 2-4 parts of Morinda officinalis, 2-4 parts of Radix Angelicae Sinensis, 2-4 parts of Cortex Phellodendri and mountain Zhu
2-4 parts of cornel;The auxiliary material is 0.5-0.7 parts of xylitol, 0.1-0.2 parts of maltodextrin, 0.1-0.2 parts of vegetable fat powder, stearic acid
The mixture 0.2-0.4ml that 0.01-0.02 parts of magnesium, palm oil and vegetable oil are formed according to arbitrary proportion.
3 parts of the ostreae testa pulverata, 3 parts of loach powder, 3 parts of yolk powder, 3 parts of danshen powder, 3 parts of Psoralen cosmetics, medlar powder 3
3 parts of part, 3 parts of Morinda officinalis, 3 parts of Radix Angelicae Sinensis, 3 parts of Cortex Phellodendri and Fructus Corni;0.6 portion of the xylitol, plants fat at 0.2 part of maltodextrin
The mixture 0.2ml that 0.2 part of end, 0.01 part of magnesium stearate, palm oil and vegetable oil are formed according to arbitrary proportion.
A method of preparing improves the integration of drinking and medicinal herbs chewing tabletting of male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 800~1000 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 50-70 DEG C, and pellet moisture 0.5%, when compression molding controls ambient humidity, relative humidity 60%
Below;
(6)Packaging:Packaging can obtain after sterilizing.
It is an advantage of the invention that:
The collective effect of each component of the application makes the present invention with more obviously raising mankind spermatozoon quality and improves immune work(
The effect of energy.The present invention is good in taste, and preparation method simple possible can be widely popularized.Effect is apparent, with strong points, for blood
Pressure, blood glucose and blood fat have no effect, and conveniently take, and convenient for preserving, preparation method is simple.
Specific implementation mode
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.People in the art
Member it should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and form into
Row modifications or substitutions, but these modifications and replacement are each fallen in protection scope of the present invention.
Embodiment 1:The present invention relates to the integration of drinking and medicinal herbs of a kind of improvement mankind spermatozoon quality and immune function to chew tabletting, packet
Major ingredient and auxiliary material are included, the major ingredient is each component of following parts by weight, and the major ingredient is integration of drinking and medicinal herbs, accounts for stagnation pressure sheet weight
90%, each component of following parts by weight, ostreae testa pulverata 2g, loach powder 2g, yolk powder 2g, danshen powder 2g, Psoralen cosmetics 1g, matrimony vine
Sub- powder 2g, Morinda officinalis 2g, Radix Angelicae Sinensis 2g, Cortex Phellodendri 2g and Fructus Corni 2g;The auxiliary material be xylitol 0.5g, maltodextrin 0.1g,
The mixture that vegetable fat powder 0.1g, magnesium stearate 0.01g, 0.2ml palm oil and vegetable oil are formed according to arbitrary proportion.
The method of the integration of drinking and medicinal herbs chewing tabletting of the improvement male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 800 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 50 DEG C, pellet moisture 0.5%, and when compression molding controls ambient humidity, relative humidity be 60% with
Under;
(6)Packaging:Packaging can obtain after sterilizing.
Embodiment 2:The present invention relates to the integration of drinking and medicinal herbs of a kind of improvement mankind spermatozoon quality and immune function to chew tabletting, including master
Material and auxiliary material, the major ingredient are each component of following parts by weight, and the major ingredient is integration of drinking and medicinal herbs, accounts for stagnation pressure sheet weight
90%, each component of following parts by weight, the ostreae testa pulverata 3g, loach powder 3g, yolk powder 3g, danshen powder 3g, Psoralen cosmetics 3g,
Medlar powder 3g, Morinda officinalis 3g, Radix Angelicae Sinensis 3g, Cortex Phellodendri 3g and Fructus Corni 3g;The xylitol 0.6g, it maltodextrin 0.2g, plants
The mixture 0.2ml that fat end 0.2g, magnesium stearate 0.01g, palm oil and vegetable oil are formed according to arbitrary proportion.
A method of preparing improves the integration of drinking and medicinal herbs chewing tabletting of male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 900 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 60 DEG C, pellet moisture 0.5%, and when compression molding controls ambient humidity, relative humidity be 60% with
Under;
(6)Packaging:Packaging can obtain after sterilizing.
Embodiment 3:A kind of integration of drinking and medicinal herbs chewing tabletting improving male's immune function, including major ingredient and auxiliary material, it is described
Major ingredient is integration of drinking and medicinal herbs, accounts for the 90% of stagnation pressure sheet weight, each component of following parts by weight, ostreae testa pulverata 4g, loach powder 4g, yolk powder
4g, danshen powder 4g, Psoralen cosmetics 3g, medlar powder 4g, Morinda officinalis 4g, Radix Angelicae Sinensis 4g, Cortex Phellodendri 4g and Fructus Corni 4g, the auxiliary material
It is xylitol 0.7g, maltodextrin 0.2g, vegetable fat powder 0.2g, magnesium stearate 0.02g, palm oil and vegetable oil according to arbitrary proportion
The mixture 0.3ml of composition.
A method of preparing improves the integration of drinking and medicinal herbs chewing tabletting of male's immune function, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 1000 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 70 DEG C, pellet moisture 0.5%, and when compression molding controls ambient humidity, relative humidity be 60% with
Under;
(6)Packaging:Packaging can obtain after sterilizing.
[Experimental result]
General information
1. choosing in October, 2017 in May, 2018,61 patients for meeting the sterility that Chinese medical discrimination is damage of kidney-YIN card press
It is grouped at random according to medical sequencing, if observation group, that is, takes this product group, control group, i.e. capsule for promoting semen generation group.Patients with infertility
Using random digits table, it is divided into observation group and control group.Wherein observation group 31,50.50 years old ± 5.0 years old age.Control
Group 30, male 14,53.40 years old ± 4.60 years old age.Two groups of Baseline Datas are comparable.
2. diagnostic criteria Western medicine diagnostic criteria, with reference to WHO's"Human seminal fluid and Mucus interaction experiment
Room inspection manual"Sorting technique Criteria Inclusion Bing Ren [5]:Man and wife 1 year after marriage, regular sexual life is not practised contraception, the wife's side
Non-reproductive system, cardiovascular system, internal system, urinary system, nervous system etc. and the relevant systemic disease of fertility,
Medical history without female infertility but because of husband reason unpregnancy person;Sperm recovery:It is 3~7 days ascetic, masturbation method or electronic
It takes smart method to take essence, passes through computer automatic analysis network analysis:< 20 × 1060-5 × 10 /ml sperm concentration >6/ml;It is living
Rate < 60%;A+b grades of sperm motility < 50%;Or the patient of a grades of sperm motility < 25% is selected.
3, therapy and the course for the treatment of
Oral this product is given by observation group, and control group takes osmanthus medicine capsule for promoting semen generation(Osmanthus medicine word Z01060147):Osmanthus medicine production of sperm glue
The key agents of capsule form:The fruit of glossy privet, Radix Codonopsis, the fruit of Chinese wolfberry, asparagus fern, Radix Ophiopogonis, plantain seed, Semen Cuscutae, mulberries, raspberry, Huang
Stilbene, red ginseng, safflower etc. belong to Chinese patent medicine formula preparation, are produced by Guangxi pharmaceutical factory of attached Rui Kang hospitals of Chinese medicine university, observation combination
The usage of control group:3 tablets each time, 3 times a day, 3 months courses for the treatment of, totally 2 courses for the treatment of, warm water delivery service, postprandial half an hour.
Half an hour warm water delivery service after meal, 3 months courses for the treatment of, totally 2 courses for the treatment of, while being practised contraception using sheath.
4, curative effect MAIN OUTCOME MEASURES
(1)Serum antisperm antibody inspection:Reagent is purchased from Shenzhen Huakang Biology Medical Engineering Co., Ltd and assists to check, mainly
Use ELISA method;(2)Sperm recovery:Sperm recovery(Ascetic 3-7 days, masturbation method, can not masturbator can be electronic
Take essence), control laboratory inspection is sent after making a collection of specimens immediately, inspection is assisted by the attached Dongguan stone row hospital laboratory of Guangdong medical university
It looks into, using computer-assisted semen analysis(Beijing mighty force sperm quality detecting system software)It measures.Measuring main project has:Essence
Liquid measure, pH value, liquefying time, a grade sperm, b grades of sperms, c grades of sperms, a+b grades of sperms, sperm concentration, rate of teratosperms etc..
(3))General curative effect evaluation criteria is with reference to health ministry"New Chinese medicine guideline of clinical investigations"[6]And WHO"Infertility
The inspection of Mr. and Mrs' standard and diagnosis handbook", two groups respectively carry out semen efamination as required at the end of pretherapy and post-treatment and each course for the treatment of,
Take the average value of 3 results.1. clinical cure:Sperm concentration, motility rate, vitality restoration are normal and the wife's side is pregnant;2. effective:Sperm
Density, motility rate, vitality restoration are normal;3. effectively:Sperm concentration, motility rate, vitality restoration promote 30% < 60% of >;4. invalid:Essence
Sub- density, motility rate, vitality restoration are unchanged after promoting < 30% or treating.
As a result:
1, after treatment in 6 months, 15 people of observation group's clinical cure, effective 4 people, effective 5 people, invalid 8
People, gross efficiency 75%;16 people of control group clinical cure, effective 4 people, effective 5 people, invalid 7 people, gross efficiency are
76%;;Ridit analyzes two groups and compares P>0.05, no significant difference.Illustrate that this product and pure Chinese medicine capsule for promoting semen generation are being treated
Curative effect indifference in terms of male immune infertility, and almost without side effect.
2, to the influence of immune function:Two groups of interleukin 2s, Serum Levers of Soluble Interleukin 2 Receptor and neoplasm necrosis
The factor only comparision contents, the concentration of interleukin 2 and Serum Levers of Soluble Interleukin 2 Receptor in the serum of this product observation group
Significantly rise and decline, with experimental group take before compared with the significant (P< of difference;0.05).And the front and back leucocyte of control group experiment
Interleukin -2 and the concentration of Serum Levers of Soluble Interleukin 2 Receptor change without conspicuousness.Experimental group and the pretherapy and post-treatment serum of control group
The concentration of tumor necrosis factor instrument is without significant changes.
3, the case where two groups of pretherapy and post-treatment sperm concentrations, motility rate, vigor check:Sperm recovery before observation group's treatment
As a result:A grades:12.5 ± 6.28, a+b grades:36.25 ± 5.92, sperm motility rate:49.44 ± 7.37, sperm concentration:15.06
±3.51;Sperm recovery result before control group treatment:A grades:20 ± 11.13, a+b grades:36.40 ± 5.46, essence
Sub- motility rate:51.57±4.33 ;Sperm concentration:13.37±3.47;Two groups of comparisons:A grades:T=- 0.960,15 P=
0.337;A+b grades:T=- 0.120, P=0.904;Motility rate:T=- 1.635, P=0.102;Density:T=- 1.914, P
=0.056。
P ﹥ 0.05 are compared before two groups of treatments, two groups are compared no significant difference before treatment, are comparable.Observation group controls
After treatment:A grades:24.03±5.62;A+b grades:52.47±8.95:Motility rate:66.16 ±8.21;Density 32.47 ±
12.62.Control group:A grades of sperms:26.53 ± 8.31, a+b grades of sperms:54.47 ± 6.89, sperm motility rate:65.87±
6.23 sperm concentration:30.20±5.73;Two groups of comparisons after treatment:It is compared after a grades:P>0.05, significant difference has statistics
Meaning illustrates that observation group is consistent with effect after control group treatment.I.e. product and osmanthus medicine capsule for promoting semen generation group are in treatment male immune
It is identical in terms of sperm quality in terms of sterility, illustrate this product other than treating oligospermatism, for immunocyte decline
The treatment of male sterility be also ideal and convenient product, can promote and apply.
The application is added to the special food materials that immune function is generated and promoted simultaneously for mankind spermatozoon and has help liver
The integration of drinking and medicinal herbs ingredient of renal function, and make dosage form into chewing tabletting, it is easy to use and immune with specific reference to patient's self-assessment
Function status is come the dosage form that adjusts and takes mode.Wherein main component:Oyster is marine organisms with high nutritive value, research
It was found that oyster there are a variety of desirable influences to ridicule the function of human body.Experiment display, body can be significantly improved after taking ostreae testa pulverata
The level of interleukin 2 reduces the level of soluble il- -2, illustrates that ostreae testa pulverata can make the immunization machine of body
It can keep stablizing.Interleukin 2 is mainly generated by the TH cells activated.TH cells are in interleukin 1 and other signals
Co stituation under just secreting leukocytes mesonium -2 4-12 h, the interleukin 2 receptor of interleukin 2 and high affinity
In conjunction with by T cell to interleukin 2 and its receptor complex progress pinocytosis, to make T cell activation.Thus, it is white thin
The generation of the interleukin 2 receptor on born of the same parents' interleukin -2 and T cell surface is the important symbol of T cell activation.T cell was both secreted
Interleukin 2, and there is interleukin 2 receptor, it is formed the positive feedback amplification of autocrine activation amplification, makes to be lived
The T cell of change clones to obtain rapid amplifying activation.Thus it is generally acknowledged that interleukin 2 and its receptor are the bases of t cell response
Plinth.Il-2 Level height shows T cell high activity.Interleukin 2 receptor mediates immune in interleukin 2
It plays an important role in reaction, Serum Levers of Soluble Interleukin 2 Receptor is a kind of important immunosuppressive substance of body.As T is thin
Born of the same parents are activated, and T cell largely generates interleukin 2 and expresses interleukin 2 receptor, interleukin 2 and leucocyte
Jie's plain-2 acceptor results in more T cell activations again after combining, hence into the cycle of positive feedback.It is solvable in the process
Property interleukin 2 receptor can be combined with interleukin 2, inhibit the leucocyte on interleukin 2 and T cell surface to be situated between
Plain-2 acceptor combine, therefore can neutralize activity of interleukin-2 solubility from cytokine -2 receptor to interleukin 2
Generation provide constraints, and by interleukin 2 dependent response inhibit the immune system being likely to occur it is excessive swash
It is living.Serum Levers of Soluble Interleukin 2 Receptor is closely related with interleukin 2, and generation all relies on T cell activation, white thin
Born of the same parents' interleukin -2 activates T cell to be allowed to generate cell membrane interleukin-2 receptor, is to generate Serum Levers of Soluble Interleukin 2 Receptor
Prerequisite, and Serum Levers of Soluble Interleukin 2 Receptor play immunoregulation effect be also by -2 work(of blocking leukocyte interleukin
Can mode, therefore in the immune system of body understand Serum Levers of Soluble Interleukin 2 Receptor and interleukin 2 level
And variation, it is vital to holding the entire immune functional state of male.Japan medical science researcher observes male sterility
1000, it is found that Zn content is insufficient in the sperm of 37 people.Trace element zinc can promote the energy of sperm, and sperm can be prevented too early
Disintegrate, is conducive to be combined with ovum, it is seen that zinc has significant impact to fertility.Oyster, the loach of more foods rich in zinc etc. is for improving essence
Protonatomic mass has certain effect.
Claims (3)
1. a kind of integration of drinking and medicinal herbs improving male's immune function chews tabletting, which is characterized in that described including major ingredient and auxiliary material
Major ingredient is integration of drinking and medicinal herbs, accounts for the 90% of stagnation pressure sheet weight, each component of following parts by weight, 2-4 parts of ostreae testa pulverata, 2-4 parts of loach powder,
2-4 parts of yolk powder, 2-4 parts of danshen powder, 1-3 parts of Psoralen cosmetics, 2-4 parts of medlar powder, 2-4 parts of Morinda officinalis, 2-4 parts of Radix Angelicae Sinensis, Huang
2-4 parts of 2-4 parts of cypress and Fructus Corni;The auxiliary material is 0.5-0.7 parts of xylitol, 0.1-0.2 parts of maltodextrin, vegetable fat powder 0.1-
The mixture 0.2-0.4ml that 0.2 part, 0.01-0.02 parts of magnesium stearate, palm oil and vegetable oil are formed according to arbitrary proportion.
2. a kind of integration of drinking and medicinal herbs improving male's immune function according to claim 1 chews tabletting, which is characterized in that institute
3 parts of the ostreae testa pulverata stated, 3 parts of loach powder, 3 parts of yolk powder, 3 parts of danshen powder, 3 parts of Psoralen cosmetics, 3 parts of medlar powder, Morinda officinalis 3
3 parts of part, 3 parts of Radix Angelicae Sinensis, 3 parts of Cortex Phellodendri and Fructus Corni;It is 0.6 part of the xylitol, 0.2 part of maltodextrin, 0.2 part of vegetable fat powder, hard
The mixture 0.2ml that 0.01 part of fatty acid magnesium, palm oil and vegetable oil are formed according to arbitrary proportion.
3. a kind of method preparing the integration of drinking and medicinal herbs chewing tabletting as claimed in claim 1 or 2 for improving male's immune function, special
Sign is, includes the following steps:
(1)It weighs:Each component is weighed according to proportioning;
(2)Screening:The major ingredient of integration of drinking and medicinal herbs is through 800~1000 mesh sievings;
(3)Dispensing:It is stirred and is uniformly mixed with auxiliary material mixing, mixing time 10 minutes;
(4)It is granulated:The screen size of sieve depending on the diameter and thickness of tabletting;
(5)It is dry:Temperature is 50-70 DEG C, and pellet moisture 0.5%, when compression molding controls ambient humidity, relative humidity 60%
Below;
(6)Packaging:Packaging can obtain after sterilizing.
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