CN106983151A

CN106983151A - A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof

Info

Publication number: CN106983151A
Application number: CN201710198925.5A
Authority: CN
Inventors: 尤俊; 季敬东
Original assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Current assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Priority date: 2017-03-29
Filing date: 2017-03-29
Publication date: 2017-07-28

Abstract

The present invention relates to a kind of inflammatory bowel disease tailored version clinical nutrition formula, including protein and amino acid, peptides, fat, carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resource food；Wherein meals elite includes millet powder, oatmeal, apple powder；Integration of drinking and medicinal herbs composition includes lily, peppermint, radix glycyrrhizae, Poria cocos, raspberry, matrimony vine, sealwort, jujube；Its preparation method is：Each component is previously prepared into powder, and well mixed corresponding formulation is made；Powder is made in integration of drinking and medicinal herbs composition water extraction concentration, freeze-drying, and vitamin and fat are handled by microencapsulation is made powder, and powder is made using freeze-drying in meals elite.Compared with prior art, nutrient formulation of the present invention can be energy, critical nutrients and the essential trace element needed for patients with inflammatory bowel is provided, and improve erythrocyte sedimentation rate, c reactive protein and the intestinal permeability symptom of patient.

Description

A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof

Technical field

The present invention relates to enteral nutrition preparation field, and in particular to a kind of inflammatory bowel disease tailored version clinical nutrition formula and its Preparation method.

Background technology

Inflammatory bowel disease is the non specific chronic inflammatory process for betiding enteron aisle, including Crohn disease (CD) and ulcer Property colitis (UC).Extensively, symptom of digestive tract weight, Relapse rate, the course of disease is long for inflammatory bowel disease extent of disease, and metabolism in addition changes, Easily occur malnutritive.Inflammatory bowel disease patient in first visit more than with malnutrition, and disease progression, medicine or operation are controlled Treatment has then more aggravated dystrophia, pretends the treatment means for inflammatory bowel disease, nutritional support and medicine, operation etc. are of equal importance, And through in the whole therapeutic process of inflammatory bowel disease.

Inflammatory bowel disease (IBD) patient occur together malnutrition 20%~85% is accounted in inpatient.Different IBD lesion Position is different, and UC lesions are limited to colon, and CD can occur in intestines and stomach all sites, especially Small bowel involvement, and influence is digested and assimilated Function, thus CD nutritions are bad more conventional compared with UC.In CD inpatients, the malnutrition that occurs together accounts for 50%~70%, Dietetic patient is up to 86.4% in CD inpatients in surgical department.

There is Body weight loss, Hypoproteinemia in IBD acute stages, up to 73% patient, (outstanding with inflammatory bowel disease and vitamin It is vitamin D and vitamin B₁₂) and microelement deficiencies, complication rate and case fatality rate rise.Under-weight in patient CD Person is up to 65%~75%, higher than patient UC (18%~62%).Hypoproteinemia person accounts for 25%~80%, UC patients in patient CD In account for 25%~50%.Childhood patient IBD there is 40% growth retardation occur, clinical manifestation is that body weight increase is not enough, battalion Support bad sexual development obstacle.

IBD is agnogenic Chronic immune dysfunction.Diet is probably that pathology starts factor, particularly high sugar, height The western diet of fat, it may be possible to increase one of startup reason of the IBD incidences of disease.In recent years, western diet and amount of exercise are reduced Make obesity or overweight patient's IBD increasing day by day, particularly children.Recent research indicate that, in children patient IBD obesity or Super severe one, which is accounted for, accounts for 20% in 23.6%, CD.IBD pathomechanism includes host immune status, intestinal microecology and extraneous ring A series of changes in border (including diet and tobacco), show as systemic inflammatory response, digestion and the malabsorption of chronic states, after Person is more more common in the patient of SBR or the history of operation that changes its course.Inflammatory factor in disease activity phase body increases, including tumour is bad Necrosis factor α etc..

Patient IBD is bad due to digesting and assimilating, and energy expenditure increase, intestines and stomach protein loss causes energy, albumen Matter, magnanimity and micronutrient, electrolyte and vitamin etc. lack, and its clinical characters has：1. patient IBD loses blood and iron lacks It is weary, cause 36%~90% inflammatory bowel disease occur, influence quality of life, childhood IBD also therefore there is cognitive ability reduction.② Vitamin B₁₂The factor, which absorbs, needs complete ileum, therefore the vitamin B in patient CD₁₂Deficient patients account for 20%, distal ileitis Up to 48% in patient, ileal resection>100cm patient is up to 100%.Vitamin B₁₂It is homocysteine-methionine generation Thank the required common factor of approach, plasma vitamin B₁₂It is the independent risk factor of Homocysteine that level is low.3. end Ileum inflammation or excision cause liposoluble vitamin (A, D, E, K) and bile salt malabsorption with lacking.Also there is β in patient IBD Carrotene and ascorbic shortage.4. there is calcium deficiency in 13%CD and 10%UC patients, and this is that ileum lesion or excision cause Enteric cavity absorption area is not enough, and vitamin D, which absorbs, to be reduced, calcium with non-absorbent aliphatic acid be combined and dietary restriction caused by.Calcium Bone loss, osteoporosis are IBD common nutritional complication caused by lacking；Such as patient applies glucocorticoid simultaneously, then bone The incidence of disease lacked with osteoporosis increases respectively to 51%~77% and 17%~28%.5. IBD medicines (Salazosulfamide Pyridine, amethopterin etc.) enteron aisle competition cause 20%~60% patient to there is folic acid deficiency, aggravate inflammatory bowel disease.Folic acid is also The required common factor of homocysteine-methionine metabolic pathway, folic acid deficiency causes Homocysteine, as CD and One of the reason for patient's UC thromboembolic events increase.6. chronic diarrhea causes hypomagnesemia.7. the zinc deficiency meeting that patient IBD is present Wound healing is influenceed, may be related to chronic intestinal fistula.8. in IBD inflammation to the early carcinomatous change stage, selenium deficiency acts on preceding apoptosis Gene, p53, NF- κ B and stress signal path expression etc..

In the nutrition treatment of inflammatory bowel disease patient, enteral nutrition (enteral nutrition, EN) is occupied importantly Position, EN can not only improve the nutritional status of patient, can also alleviate acute attack symptom, extend disease-free period.EN can directly subtract Light CD inflammatory activities, being embodied in the erythrocyte sedimentation rate, c reactive protein and intestinal permeability of patient is all improved.In addition, EN To safeguarding that growth, propagation and the mucosal barrier function of intestinal mucosa have special role.Although current hormone is to adult's CD inducer remissions Rate is higher than EN, and short compared with EN the time required to inducer remission, but is due to that hormone is restricted in clinical practice and with tight The side effect of weight, makes EN be used widely when treating adult acute phase CD as a kind of alternative measure of hormone.Battalion Support and support to improve nutrition situation, the unique advantage with nutrition treatment while inducer remission.And current pole on the market The rare special nutritional formula for inflammatory bowel disease patient.

The content of the invention

It is an object of the invention to overcome defect of the prior art to match somebody with somebody there is provided a kind of inflammatory bowel disease tailored version clinical nutrition Side and preparation method thereof, it provides science, comprehensive clinical nutrition formula, and preparation method for inflammatory bowel disease patient first It is advanced.Inflammatory bowel disease tailored version clinical nutrition formula prepared by the present invention provides science, comprehensively clinic for patients with inflammatory bowel Nutritional support；On the basis of the basal energy and nutrient of needed by human body are provided, moreover it is possible to mitigate the inflammatory activities of inflammatory bowel disease, Being embodied in the erythrocyte sedimentation rate, c reactive protein and intestinal permeability of patient is all improved；In addition, addition is to safeguarding intestinal mucosa Growth, propagation and mucosal barrier function have the integration of drinking and medicinal herbs composition of special role, natural plants compound and new resources food Product, help to extend the paracmasis, reduce recurrence rate, reduce permanent intestines stoma ratio.

To achieve the above object, the present invention is adopted the following technical scheme that：

On the one hand, the present invention provides a kind of inflammatory bowel disease tailored version clinical nutrition formula, including following component：Protein and Amino acid, peptides, fat, carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, medicine food are same Derived components, natural plants compound and new resource food；Wherein, the meals elite includes millet powder, oatmeal, apple Fruit powder；Wherein, the integration of drinking and medicinal herbs composition includes lily, peppermint, radix glycyrrhizae, Poria cocos, raspberry, matrimony vine, sealwort, jujube.

In order to further optimize above-mentioned technical proposal, the technical measures that the present invention is taken also include：

Preferably, the inflammatory bowel disease tailored version clinical nutrition formula, in addition to food thickening agent and food additives, institute Food thickening agent is stated in guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one, the food additives are at least one of Aspartame, flavoring essence spices, brown sugar.

Preferably, the good protein that the protein and amino acid are provided accounts for gross protein and reaches more than 70%.

Preferably, the peptides account for gross protein and reach more than 2%.

Preferably, n-6 aliphatic acid in the fat：N-3 aliphatic acid=3~4:1, medium chain triglyceride accounts for total lipid content 30%~50%.

Preferably, the carbohydrate is without lactose, using lactose-free formula.

Preferably, the dietary fiber is water-soluble dietary fiber, using low fiber prescription.

Preferably, the parts by weight of the component are：20~40 parts of protein and amino acid, 1~3 part of peptides, fat 5~ 20 parts, 20~60 parts of carbohydrate, 1~3 part of dietary fiber, 0.6~1.2 part of macroelement, trace element 0.01-0.06 Part, 0.05~0.25 part of vitamin, 0.2~1 part of meals elite, 0.1~6 part of integration of drinking and medicinal herbs composition, natural plants compound 0.1-1 parts and 0.02-0.2 parts of new resource food.

Preferably, the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：It is 0-1 parts of lily, 0-1 parts of peppermint, sweet Careless 0-1 parts, 0-1 parts of Poria cocos, 0-1 parts of raspberry, 0-1 parts of matrimony vine, 0-1 parts of sealwort, 0-1 parts of jujube.

Preferably, the protein is selected from hydrolyzing lactoalbumin powder, soy bean protein hydrolysate, whole milk powder, dried whole-egg, newborn iron At least one of albumen, bovine colostrum, protein peptides；The amino acid is selected from 1B-Pidolidone, Pidolidone, L- At least one of arginine, L-Trp, Glu, taurine, Valine, ILE, L-Leu；Its In, the protein peptides are selected from soybean oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino At least one of peptide, ovalbumin peptide.

Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically it is described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm oil, butter, Cream, lard, medium chain triglyceride, lecithin, single diglycerine fatty acid ester.

Preferably, the carbohydrate include fructose, rock sugar, glucose, maltodextrin, tapioca, cornstarch, At least two in resistant starch.

Preferably, the dietary fiber is water-soluble dietary fiber and insoluble dietary fiber, and it includes inulin, konjaku In powder, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber at least It is a kind of.

Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate At least one of with magnesium gluconate.

Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.

Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D₃, vitamin E, vitamin K₁ At least one of.

Preferably, the water soluble vitamin is selected from vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, vitamin At least one of C, pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.

Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；Wherein described cereal it is main by rice meal, millet powder, black rice flour, coixlacrymajobi powder, One kind in corn flour, wheat germ powder, oatmeal, buckwheat or at least two compositions, the beans it is main by peameal, it is green One kind or at least two compositions in bean powder, black bean powder, red bean powder, soy meal, the potato class is mainly made up of common yam rhizome powder, described Vegetable powder is main by one in carrot meal, white radish powder, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder, cucumber powder Plant or several compositions, the Homonemeae is main by the one or more in mushroom powder and white fungus powder, and the nut-seed class is main It is lotus nut starch, the fish and shrimp are mainly made up of the one or more in salmon powder and cod meal, the poultry meat master If being made up of the one or more in chicken meal, powdered beef, the fruits are main by red date powder, longan powder, apple powder, cherry One or more of compositions in peach powder, citrus powder, pyrus nivalis powder；The preferred millet powder of meals elite, oatmeal, apple powder.

Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one of sterol, lycopene, resveratrol, allicin；The natural plants compound is preferably l-cn.

Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, freshwater mussel In meat polysaccharide, bamboo-leaves flavones, CPP, avenabeta glucosan, yeast beta-dextran, leaf of Moringa, xylo-oligosaccharide extremely Few one kind；The new resource food is preferably avenabeta glucosan.

On the other hand, the present invention relates to a kind of preparation method of above-mentioned inflammatory bowel disease tailored version clinical nutrition formula, including Following steps：

Step 1: by the protein and amino acid of predetermined weight number, peptides, fat, carbohydrate, dietary fiber, Macroelement, trace element, vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food are prepared into respectively Particle diameter is 150~250 μm of powder；

It is well mixed Step 2: powder prepared by the step one is poured into cone-type mixer successively；

Step 3: using the step one be well mixed powder be prepared into nutrient powder, nutrition emulsion, capsule, tablet, At least one of pill or oral liquid；

Wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, water extraction is concentrated, and concentrate is carried out into freeze-drying system Into integration of drinking and medicinal herbs component powders；

Wherein, the vitamin and fat are handled by microencapsulation respectively is prepared into vitamin powder and fat powder；

Wherein, the meals elite is prepared into meals elite powder using freeze drying process.

Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, is added 3~8 times of the water that weight is raw material weight, is carried out immersion 3 ~4 hours, then soak is carried out to decoct 30~60min, filtering removes raw material, leaves and takes decoction liquor, carries out decoction liquor dense Contracting, freeze-drying, then sieving prepare integration of drinking and medicinal herbs component powders.

Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) it regard liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer are as wall material, high-pressure homogeneous emulsification, and spraying is instantaneous to be dried, and screening prepares liposoluble Property vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, whey egg One or more in white powder, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer are mixed as wall material Close uniform, spraying is instantaneous to be dried, and screening prepares water soluble vitamin powder.

Preferably, the specific implementation step of the fatty micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall material with Water mixed dissolution prepares emulsion；After the stirring mixing of above-mentioned emulsion, emulsifying homogeneous processing is carried out, spraying is then carried out dry Dry, screening prepares powdered oil, and powdered oil is compared with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), One or more in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin；The wall Material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer.

Preferably, the freeze drying process of the meals elite is comprised the following steps that：Choose raw material and smashed to pieces juxtaposition Enter in refrigerator and freezed, the raw material after freezing are placed in into heating in sealed vacuum tank dehydrates it, described Then the vacuum degree control of vacuum tank is heated to material temperature be solved below the maximum temperature of its permission in 10-30Pa Drying is analysed, the time dehydrated is 1~2h, and the time of the parsing-desiccation is 4~6h, and the raw material for drying completion is entered The ground sieve of row is prepared into meals elite powder.

The present invention eats same using with the medicine for having special role to safeguarding growth, propagation and the mucosal barrier function of intestinal mucosa Derived components, it includes lily, peppermint, radix glycyrrhizae, Poria cocos, raspberry, matrimony vine, sealwort, jujube.

Lily can raise peripheral leukocytes, and be improved the effect of immunity of organisms, and lily gavage can prevent endoxan Caused animal leukopenia；Colchicin contained by lily can suppress the propagation of cell, and with resist oxygen lack with it is antifatigue Effect；Water-soluble polysaccharide contained by lily can promote Immune Function.

Active ingredient peppermint oil and its main component menthol in peppermint is to the rabbit under ex vivo situation, guinea pig ileum The tension force of activity, intensity, intensity-Tension Difference have obvious inhibitory action, and antihistamine, acetylcholine, barium chloride etc. can be drawn The intestinal tube activity risen is hyperfunction.

Radix glycyrrhizae can reduce intestinal tube tensity, reduce shrinkage amplitude, the isoliquiritigenin contained by it to carbachol, potassium chloride, The mouse jejunum of barium chloride induction, which shrinks, strong spasmolysis, and the mechanism of action of radix glycyrrhizae spasmolysis is probably that isoliquiritigenin can be non-competing Suppress to striving property contraction caused by acetylcholine, while isoliquiritigenin is a kind of aldose reductase inhibitor, by suppressing epoxy Synthase, LOX, the activity of peroxidase carry out anti-platelet aggregation, play antiinflammatory action；Radix Glycyrrhizae total saponins contained by it With direct antiinflammatory action, its antiinflammatory action is with reducing the generation of Macrophage Inflamatory medium and discharging, suppress arachidonic acid generation The key enzyme for thanking to approach PGE2 synthesis is closely related；Glycyrrhizin contained by it can improve the threshold of pain of mouse in mouse hot-plate experiment Value, reduces mouse writhing number of times in acetic acid twisting experiment, and paraxylene causes mice auricle swelling to have obvious inhibitory action.

Active ingredient pachymaran body in Poria cocos has the effect of enhancing immunologic function, and it has anti-atrophy of thymus gland and anti- The function that spleen increases and tumor suppression grows；Carboxymethylpachymaran have immunological regulation, protecting liver, lowering enzymes, indirectly it is antiviral, induce With Stimulation effect interferon, mitigate radiation side reaction, induce with a variety of physiologically actives such as Stimulation effect leukoregulin, without bad poison Side effect；Pachymaran truly has and pointedly protects immune organ, increases cellular immune function, so as to improve body condition, increases Plus anti-infection ability, especially there is strong effect to old human immunity function.

Contained hippuric acid can change the pH-value of enteron aisle and the pH-value of the urinary tract in raspberry, meanwhile, in raspberry Tannic acid energy antistaphylohemolysin, salmonella and Escherichia coli, strengthen human immunity force；Ellagic acid in raspberry can be supported Many chemical carcinogens such as anti-polycyclic aromatic hydrocarbon, nitrosamine, mycotoxin and aflatoxins, can protect people to show consideration for Body tissue, strengthens body function；In raspberry contain natural aspirin (i.e. salicylic acid), can Antipyretic, anticoagulant, also may be used Reduce the incidence of cardiovascular and cerebrovascular embolism；Contain substantial amounts of anthocyanidin in raspberry, it is the clear of efficient resisting oxidation free radical Except agent, with powerful antioxidation activity.

Active ingredient LBP-X in matrimony vine can strengthen mice spleen lymphocytes proliferation reaction, be used in combination LBP and ConA has synergy；Matrimony vine contains the human body essential nutrient element such as abundant carrotene, vitamin and calcium, iron, and matrimony vine has The effect clear liver and improved vision, it can also improve immunity of organisms, regulation blood glucose blood pressure, promote gastrointestinal peristalsis, and it is also to hematopoiesis function There is facilitation.

Sealwort, which has, improves CY induced mice marrow hemopoiesis functions, increases leucocyte and red blood cell number, is incarnadined marrow more Cell (PCE) micronuclear rates (MNR) declines (P ＜ 0.01), can improve mouse peritoneal macrophage function.

Active ingredient date polysaccharide in jujube can significantly improve the phagocytic function of internal mononuclear phagocyte system；Jujube Thick many candies, neutral polysaccharide and acidic polysaccharose can promote the propagation of lymphocyte, and neutral polysaccharide is to lymphocyte proliferation Facilitation is stronger than the facilitation of acidic polysaccharose.

The water-soluble dietary fiber of the present invention also addition 65~75%, water-soluble dietary fiber can be by intestinal flora metabolism ferment Solve as a variety of short chain fatty acids, including acetic acid, propionic acid, butyric acid etc., short chain fatty acids are the significant energies of gastrointestinal tract epithelial cell Material, short chain fatty acids make intestinal epithelial cell have more preferable nutritional status, reduce noxious material and Inflammatory substances glutinous by intestines Film enters circulation；Short chain fatty acids also promote gastrointestinal tract epithelial cell to secrete mucin and gastrointestinal peptide, and they are to enhancing intestines and stomach Barrier function play an important role.

The present invention uses new resource food avenabeta glucosan, and it has β-(1,3) glycosidic bond, therefore can influence immune Function；Beta glucan is considered as the immunologic stimulant of macrophage, T/B lymphocytes and NK cells, and oral oat β-Portugal gathers Sugar can increase the ability of systemic immunity and intestine immunity.Avenabeta glucosan enters after human body alimentary canal, due to human intestine Inside lack 1,4 beta-glucanase, avenabeta glucosan is not digested absorption in the small enteral of epimere, in big enteral, probiotics passes through secretion Degraded to extracellular glycosidase, then reabsorb utilize, such avenabeta glucosan can as probiotics carbon source, choosing Growth and the vigor of probiotics are stimulated to selecting property, so as to promote probiotics to breed.On the other hand, avenabeta glucosan is used as benefit The fermentation substrate of raw bacterium, short chain fatty acids (SCFA) and butyric acid can be produced in colon by anaerobic bacteria catabolism.

N-3 unrighted acids in the fat that the present invention is used can block generation and the egg of arachidonic acid metabolite The activity of white kinase c, has potential therapeutic action to inflammatory bowel disease.

Compared with prior art, the present invention has following excellent effect：

(1) modern nutriology achievement in research is combined by the present invention with Traditional Chinese medical theory, passes through the organic of various components Combination, various functions is merged, and pass through the synergy between active ingredient, humidification effect.Match somebody with somebody by the present invention The food that side makes can not only supplement nutrition needed for patients with inflammatory bowel, moreover it is possible to promote body condition to change using medicinal herb componentses It is kind.

(2) the integration of drinking and medicinal herbs composition of inventive formulation food addition has growth, propagation and the mucous membrane to safeguarding intestinal mucosa Barrier function has special role, and the water-soluble dietary fiber of addition can reduce noxious material and Inflammatory substances are entered by intestinal mucosa Enter circulation, the new resource food of addition has the ability of increase systemic immunity and intestine immunity, in said components and albumen Under the synergy of matter, fat etc., the erythrocyte sedimentation rate, c reactive protein and intestinal permeability of patients with inflammatory bowel can effectively improve Symptom, actively carries out the treatment of inflammatory bowel disease symptom, with early recovery.

(3) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, it is easy to be well mixed with other powdered components；And use micro-capsule bag Bury after technology, grease is embedded in wall material, so that the contact with air is avoided to strengthen inoxidizability, so as to play guarantor The maximum effect of strong type grease；The present invention prepares integration of drinking and medicinal herbs composition and meals elite using freeze drying process, ensure that The activity of itself of nutriment, the technique excludes more than 95%~99% moisture, enables the powder prepared after drying long-term Preserve and never degenerate.

(4) raw material of inflammatory bowel disease tailored version clinical nutrition formula of the present invention is previously prepared in preparation process Into 150~250 μm of powder, this make it that, when preparing finished product, each nutrition composition can be well mixed, it is ensured that in unit volume The content of each nutrition composition is identical, while when preparing liquid type preparation, each nutrition composition can it is fully dispersed and be completely dissolved to In solvent, prevent occurring solid precipitation in liquid, effect of finished product product has been effectively ensured.

Embodiment

The present invention provides a kind of a erythrocyte sedimentation rate, c reactive protein and intestines with improvement patient for patients with inflammatory bowel The clinical nutrition formulation product of mucous membrane permeability symptom, includes the component of following parts by weight：Protein and amino acid 20~40 Part, 0.1~3 part of peptides, fat 5~20 parts, 20~60 parts of carbohydrate, 1~3 part of dietary fiber, macroelement 0.6~ 1.2 parts, 0.01-0.06 parts of trace element, 0.05~0.25 part of vitamin, 0.2~1 part of meals elite, integration of drinking and medicinal herbs composition 0.1 0.02-0.2 parts of~6 parts, 0.1-1 parts of natural plants compound and new resource food；Wherein, protein and the amino acid institute The good protein of offer accounts for gross protein and reaches more than 70%, and the peptides account for gross protein and reach more than 2%；The fat Middle n-6 aliphatic acid：N-3 aliphatic acid=3~4:1；The dietary fiber be water-soluble dietary fiber, account for total formula weight 1~ 3%.

With reference to embodiment, the embodiment to the present invention is further described.Following examples are only used for more Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.

Embodiment 1

Inflammatory bowel disease tailored version clinical nutrition formula of the present invention includes hydrolyzing lactoalbumin powder 11.45g, soybean water Solve albumen 5.87g, milk powder 3.63g, dried whole-egg 0.18g, colostrum 0.09g, taurine 0.12g, soy oligosaccharides Gly-His-Lys 0.1g, sea Foreign fish oligopeptide powder 0.1g；Perilla herb oil 0.18g, coconut oil 0.78g, soybean oil 1.27g, olive oil 0.78g, medium chain triglyceride 3.08g；Maltodextrin 51.06g, tapioca 8.63；Water-soluble dietary fiber 1.98g in dietary fiber, it includes inulin, evil spirit At least one of taro powder, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin；Often Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in secondary element；Iron 0.011g in trace element, iodine 0.00014g, Zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g、 Vitamin E 0.009g；Vitamin B in water soluble vitamin₁0.001g, vitamin B₂0.001g, vitamin B₆ 0.001g、 Vitamin B₁₂0.000002g, vitamin C 0.15g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Meals essence Magnificent 0.45g, the meals elite includes millet powder, oatmeal, apple powder；Lily 0.05g, peppermint in integration of drinking and medicinal herbs composition 0.05g, radix glycyrrhizae 0.05g, Poria cocos 0.05g, raspberry 0.05g, matrimony vine 0.05g, sealwort 0.05g, jujube 0.05g；Natural plants L-cn 0.64g in compound；Avenabeta glucosan 0.02g in new resource food.

Embodiment 2

Inflammatory bowel disease tailored version clinical nutrition formula of the present invention includes hydrolyzing lactoalbumin powder 11.45g, soybean water Solve albumen 5.87g, milk powder 3.63g, dried whole-egg 0.18g, colostrum 0.09g, taurine 0.12g, soy oligosaccharides Gly-His-Lys 0.1g, sea Foreign fish oligopeptide powder 0.1g；Perilla herb oil 0.18g, coconut oil 0.78g, soybean oil 1.27g, olive oil 0.78g, medium chain triglyceride 3.08g；Maltodextrin 51.06g, tapioca 8.63；Water-soluble dietary fiber 1.98g in dietary fiber, it includes inulin, evil spirit At least one of taro powder, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin；Often Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in secondary element；Iron 0.011g in trace element, iodine 0.00014g, Zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g、 Vitamin E 0.009g；Vitamin B in water soluble vitamin₁0.001g, vitamin B₂0.001g, vitamin B₆ 0.001g、 Vitamin B₁₂0.000002g, vitamin C 0.15g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Meals essence Magnificent 0.45g, the meals elite includes millet powder, oatmeal, apple powder；Lily 0.1g in integration of drinking and medicinal herbs composition, peppermint 0.1g, Radix glycyrrhizae 0.1g, Poria cocos 0.1g, raspberry 0.1g, matrimony vine 0.1g, sealwort 0.1g, jujube 0.1g；It is left-handed in natural plants compound Carnitine 0.3g；Avenabeta glucosan 0.02g in new resource food.

Embodiment 3

Inflammatory bowel disease tailored version clinical nutrition formula of the present invention includes hydrolyzing lactoalbumin powder 11.45g, soybean water Solve albumen 5.87g, milk powder 3.63g, dried whole-egg 0.18g, colostrum 0.09g, taurine 0.12g, soy oligosaccharides Gly-His-Lys 0.1g, sea Foreign fish oligopeptide powder 0.1g；Perilla herb oil 0.18g, coconut oil 0.78g, soybean oil 1.27g, olive oil 0.78g, medium chain triglyceride 3.08g；Maltodextrin 51.06g, tapioca 8.63；Water-soluble dietary fiber 1.98g in dietary fiber, it includes inulin, evil spirit At least one of taro powder, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin；Often Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in secondary element；Iron 0.011g in trace element, iodine 0.00014g, Zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g、 Vitamin E 0.009g；Vitamin B in water soluble vitamin₁0.001g, vitamin B₂0.001g, vitamin B₆ 0.001g、 Vitamin B₁₂0.000002g, vitamin C 0.15g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Meals essence Magnificent 0.45g, the meals elite includes millet powder, oatmeal, apple powder；Lily 0.2g in integration of drinking and medicinal herbs composition, peppermint 0.2g, Radix glycyrrhizae 0.2g, Poria cocos 0.2g, raspberry 0.2g, matrimony vine 0.2g, sealwort 0.2g, jujube 0.2g；It is left-handed in natural plants compound Carnitine 0.8g；Avenabeta glucosan 0.02g in new resource food.

Embodiment 4

Inflammatory bowel disease tailored version clinical nutrition formula of the present invention includes hydrolyzing lactoalbumin powder 11.45g, soybean water Solve albumen 5.87g, milk powder 3.63g, dried whole-egg 0.18g, colostrum 0.09g, taurine 0.12g, soy oligosaccharides Gly-His-Lys 0.1g, sea Foreign fish oligopeptide powder 0.1g；Perilla herb oil 0.18g, coconut oil 0.78g, soybean oil 1.27g, olive oil 0.78g, medium chain triglyceride 3.08g；Maltodextrin 51.06g, tapioca 8.63；Water-soluble dietary fiber 1.98g in dietary fiber, it includes inulin, evil spirit At least one of taro powder, galactooligosaccharide, FOS, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin；Often Calcium 0.2g, phosphorus 0.21g, potassium 0.08g, sodium 0.02g, magnesium 0.15g in secondary element；Iron 0.011g in trace element, iodine 0.00014g, Zinc 0.007g；Vitamin A 0.0006g, beta carotene 0.000057g, vitamin D in liposoluble vitamin₃ 0.000001g、 Vitamin E 0.009g；Vitamin B in water soluble vitamin₁0.001g, vitamin B₂0.001g, vitamin B₆ 0.001g、 Vitamin B₁₂0.000002g, vitamin C 0.15g, pantothenic acid 0.003g, folic acid 0.000165g, nicotinic acid 0.0165g；Meals essence Magnificent 0.45g, the meals elite includes millet powder, oatmeal, apple powder；Lily 0.1g in integration of drinking and medicinal herbs composition, peppermint 0.1g, Radix glycyrrhizae 0.1g, Poria cocos 0.1g, raspberry 0.1g, matrimony vine 0.1g, sealwort 0.1g, jujube 0.1g；It is left-handed in natural plants compound Carnitine 0.64g；Avenabeta glucosan 0.2g in new resource food.

Embodiment 5

The preparation method of inflammatory bowel disease tailored version clinical nutrition formula containing embodiment 1- embodiments 4 is as follows：

1) powdered oil (powder fat) is prepared：

A) the wall material aqueous solution is prepared：Take 10 grams of maltodextrin, 4 grams of soybean protein isolate, 5 grams of whole-fat milk powder, dietary fiber 2.5 grams, 5 grams of PURE WHEY, 1.5 grams of oligoisomaltose, 0.2 gram of Arabic gum, 50 milliliters of water stirs (side of having ready conditions Heating side is stirred to 60 DEG C, and room temperature is cooled to after being kept for 30 minutes).

B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 5.73 milliliters of greases monoglyceride 0.73 milliliter, 1.20 milliliters of soybean oil, 0.73 milliliter of coconut oil, 0.17 milliliter of perilla herb oil, 2.90 milliliters of medium chain triglyceride).

C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80.

D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.

E) addition stabilizer agar takes 0.1 gram (total solid concentration is 0.2%) to enter after mixed solution, is settled to water Disperse 2 minutes at a high speed under 200 milliliters (total solid concentration is 25%), 20000r/min.

F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).

G) obtained emulsion is spray-dried, EAT is 195 DEG C, leaving air temp is 80 DEG C.Collect powder Grease (powder fat).

2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, add weight be raw material weight 3~8 times of water, carry out immersion 3~4 hours, then to soak Carry out decocting 30~60min, filtering removes raw material, leaves and takes decoction liquor, concentrate decoction liquor, be freeze-dried, with 60~80 Mesh sieve point prepares integration of drinking and medicinal herbs component powders；

3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material It is instantaneous to dry, prepare liposoluble vitamin powder with 60~80 mesh sieves point；Using the water soluble vitamin of predetermined weight number as Core, from maltodextrin, lipoprotein as wall material, is well mixed, and spraying is instantaneous to be dried, and is prepared with 60~80 mesh sieves point water-soluble Property vitamin powder；

4) meals elite powder is prepared：Selection raw material, which are smashed to pieces to be placed into refrigerator, to be freezed, after freezing Raw material be placed in sealed vacuum tank heating and dehydrate it, the vacuum degree control of the vacuum tank is in 10- 30Pa, is then heated to material temperature to carry out parsing-desiccation, the time dehydrated below the maximum temperature of its permission For 1~2h, the time of the parsing-desiccation is 4~6h, and the raw material for drying completion was ground into 60~80 mesh sieves is prepared into Meals elite powder.

5) by the protein and amino acid of predetermined weight, peptides, carbohydrate, dietary fiber, macroelement, micro member Element, meals elite, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；

6) by step 1)~step 5) obtained by powder sequentially add the mixers of cone-type mixer or other forms and mix Uniformly obtained formula mixture is closed, it is standby after sterilization processing；

7) according to conventional technical means by step 6) in formula mixture be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral liquid.

In step 7) in, optionally increase appropriate food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, flavoring essence spices, brown sugar；More preferably carragheen, Arabic gum, Guar Glue, Aspartame, flavoring essence spices.

Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent production The danger of green powder blast.

Embodiment 6- inflammatory bowel diseases are tested

The present embodiment is formulated to mouse idiopathic colitis for the inflammatory bowel disease tailored version clinical nutrition that the present invention is provided Inhibitory action.

This experiment selection interleukin-10 gene knockout (IL-10-/-) mouse 20, IL-10-/- mouse can spontaneous chronic intestines Inflammation, its pathogenesis, characteristics of lesion are close to mankind CD.IL-10-/- mouse is randomly divided into treatment group and control group, every group 10 Only.The nutrient powder that treatment group prepares per 1~embodiment of the average daily gavage embodiment of the present invention 4, control group is per average daily gavage equal amount Physiological saline, Therapy lasted eight weeks.

1) influence of mouse weight

Since first administration, it being determined daily and takes in appetite, claim within every 3 days 1 body weight, the final each group body weight that calculates increases Plus, it the results are shown in Table 1.

The inflammatory bowel disease tailored version clinical nutrition of table 1 is formulated the influence to mouse weight

As can be known from the above table, nutrient formulation of the present invention can significantly improve the body weight increase of IL-10-/- mouse.

2) disease activity index is assessed

Since first administration, disease activity index scoring successively is carried out weekly, content includes having blood in stool, the prolapse of rectum, dilute Just, horripilation, diarrhoea or with serious rectum abjection, above-mentioned each item rating is 1 point, the total score scored every time add for it and, Score weekly once, the adduction result of the scoring of continuous eight weeks is as shown in the table.

	Control group (physiological saline)	Treatment group's (nutrient powder)
			Embodiment 1	15.6	12.0
Embodiment 2	15.8	11.5
			Embodiment 3	15.4	11.2
Embodiment 4	15.5	11.4

As can be known from the above table, the disease activity index scoring for the treatment of group is lower than control group, and this shows battalion of the present invention Foster formula can suppress the development of inflammatory bowel disease.

3) colon's pathological observation

Drawn by micro- sem observation, control group IL-10-/- mouse mucous hyperemia, erosion, it is seen that ulcer is formed, and is controlled Treatment group symptom is lighter compared with control group, and this shows that the intestinal inflammatory journey of mouse can be reduced by eating nutrient formulation of the present invention Degree.

Tested more than, formulation product prepared by the present invention can make it that the body weight of the mouse of inflammatory bowel disease models is bright Aobvious rise, disease activity index scoring is significantly lower than control group, and its inflammatory symptoms shows system of the present invention compared with control group relatively light this Standby formulation product can suppress murine chronic enteritis and develop, and have certain therapeutic action to murine chronic enteritis.

The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it is any to the practicality carry out equivalent modifications and replace In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and repaiied Change, all should be contained within the scope of the invention.

Claims

1. a kind of inflammatory bowel disease tailored version clinical nutrition formula, it is characterised in that including following component：Protein and amino acid, Peptides, fat, carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs composition, Natural plants compound and new resource food；

Wherein, the meals elite includes millet powder, oatmeal, apple powder；

Wherein, the integration of drinking and medicinal herbs composition includes lily, peppermint, radix glycyrrhizae, Poria cocos, raspberry, matrimony vine, sealwort, jujube.

2. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that also including food Thickener and food additives, the food thickening agent are guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, fine jade At least one of fat, gelatin, Arabic gum, the food additives be Aspartame, flavoring essence spices, brown sugar in extremely Few one kind.

3. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the protein Gross protein, which is accounted for, with the good protein that amino acid is provided reaches more than 70%.

4. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the peptides are accounted for Gross protein reaches more than 2%.

5. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that in the fat N-6 aliphatic acid：N-3 aliphatic acid=3~4:1, medium chain triglyceride accounts for the 30%~50% of total lipid content.

6. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the carbon aquation Compound is without lactose, using lactose-free formula.

7. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the meals are fine Tie up as water-soluble dietary fiber, using low fiber prescription.

8. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that the component Parts by weight are：20~40 parts of protein and amino acid, 1~3 part of peptides, 5~20 parts of fat, 20~60 parts of carbohydrate, 1~3 part of dietary fiber, 0.6~1.2 part of macroelement, 0.01-0.06 parts of trace element, 0.05~0.25 part of vitamin, meals 0.2~1 part of elite, 0.1~6 part of integration of drinking and medicinal herbs composition, 0.1-1 parts of natural plants compound and new resource food 0.02-0.2 Part.

9. a kind of inflammatory bowel disease tailored version clinical nutrition formula according to claim 1, it is characterised in that integration of drinking and medicinal herbs into Point in 0-1 parts of lily, 0-1 parts of peppermint, 0-1 parts of radix glycyrrhizae, 0-1 parts of Poria cocos, 0-1 parts of raspberry, 0-1 parts of matrimony vine, 0-1 parts of sealwort, 0-1 parts of jujube.

10. a kind of preparation method being formulated such as inflammatory bowel disease tailored version clinical nutrition according to any one of claims 1 to 9, It is characterised in that it includes following steps：

Step 1: by the protein and amino acid of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, It is 150 that trace element, vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food are prepared into particle diameter respectively ~250 μm of powder；

Step 3: being prepared into nutrient powder, nutrition emulsion, capsule, tablet, ball using the powder being well mixed in the step 2 At least one of agent or oral liquid；

Wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, water extraction is concentrated, and concentrate progress freeze-drying is made into medicine Eat homologous component powders；