CN108703365A - Protein allergy tailored version clinical nutrition formula and preparation method thereof - Google Patents

Protein allergy tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN108703365A
CN108703365A CN201810445032.0A CN201810445032A CN108703365A CN 108703365 A CN108703365 A CN 108703365A CN 201810445032 A CN201810445032 A CN 201810445032A CN 108703365 A CN108703365 A CN 108703365A
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parts
powder
protein
allergy
fat
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
    • A23L11/05—Mashed or comminuted pulses or legumes; Products made therefrom
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    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
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    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10—Cereal-derived products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention provides a kind of protein allergy tailored version clinical nutrition formula, including following component and its parts by weight：15-21 parts of protein and amino acid, 11-15 parts of fat, 52-57 parts of carbohydrate, 3.4-4.2 parts of dietary fibers, 1.2-1.8 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.1-0.3 parts of water soluble vitamins, 0.005-0.11 parts of nucleotide, 0.02-0.06 parts of natural plants compounds；The present invention also provides the preparation methods of above-mentioned clinical nutrition formula.The present invention can improve patient body quality, enhancing immune function, Reduce allergy symptom, prevent food protein allergy crowd from allergic reaction occurs.

Description

Protein allergy tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to nutrient formulation field more particularly to a kind of protein allergy tailored version clinical nutrition formula and its systems Preparation Method.
Background technology
Numerous research reports point out that incidence is in continue ascendant trend to anaphylactia in recent years, and the incidence of allergy is As the 6th of global disease, it has also become endanger a kind of common chronic disease of children's physical and mental health, the U.S. is used for every year The medical expenses of children's allergy reach hundred million dollars of 2-4.
In numerous anaphylactias, food hypersenstivity is one of main inducement.Food hypersenstivity is body to intake A kind of adverse immune reaction that food protein generates, food hypersenstivity have become public health problem of increasing concern, baby Child's period since gastrointestinal tract is not yet reached maturity, immune system do not develop yet it is perfect, therefore be easy to occur food hypersenstivity, baby Child's period food hypersenstivity incidence becomes apparent from higher than adult, and infant food allergy is easy to cause infantile colic, what is more It can cause the general reaction of anaphylactic shock, it also occur that sudden death syndrome.
In numerous food hypersenstivities, protein allergy is one of most common food hypersenstivity.Easily leading to infantile allergy Anaphylactogen in, main source has milk, soybean, wheat, peanut, nut and an egg, in protein allergies source therein predominantly Milk protein and food proteins.There are mainly four types of main proteins, including beta lactoglobulin, gamma Globulin, lactoalbumin in milk And casein, wherein beta lactoglobulin and casein is two common anaphylactogens.It, can after these anaphylactogens enter human organism To be mediated by IgE, make mast cell sensitization and activate, discharges the substances such as a large amount of serotonin, slow sharp skin, it is more to occur The allergic phenomena of organ and system；Can also be mediated by non-IgE, as acidophil mediate or the mediation of falling T cell to milk egg It is white to generate serial allergic reaction, it can show as eczema, nettle rash, pruitus, lip, facial edema in skin；Digestive System can show as nausea,vomiting,diarrhea or stool band blood, enterospasm, constipation, abdominal distension, difficulty with feeding etc.；Typical respiratory tract Symptom includes rhiocnesmus, sneezing, runny nose, coughs, pants, hoarseness, and CMPA even can cause fatal larynx water compared with severe one Swollen, asphyxia and anaphylactic shock；Part infant can cause malnutritive, anaemia and growth and development slow due to that cannot intervene in time It is slow, therefore clarify a diagnosis and treat in early days and is extremely important.
In recent years, as people's lifestyle changes, significantly reducing children's exposed earlier microflora and cause of disease The chance of body, so numerous easy milk protein allergy induced in protein allergy disease becomes infant food allergy In one of most common protein allergy.It is shown according to related data, the incidence of children's milk protein allergy accounts for 2%- within 1 years old 7.5%.Atopic dermatitis is one of the major complications of milk protein allergy, shows as inflammatory, pruritic, recurring skin Disease brings serious influence to the growth and development of children.Since most of regular convention formula milk powder are improved by cow's milk, cow's milk Middle casein and lactalbumin antigenicity are stronger, are easy to cause baby and protein allergy reaction occurs.Breast-feeding helps to keep away The intake for exempting from foreign protei reduces the occurrence risk of anaphylactia, but current Pure breast feeding to reduce sensibiligen quantity It is less.
Foreign study, which shows to feed using hydrolyzed formulas milk powder when breast milk deficiency, can prevent the generation of anaphylactia, But still there is the research of the allergy prevention effect of appropriate hydrolyzed formulas in the country pending.It is directed to milk protein allergy at present, it can be with It gives amino acid formula milk or depth hydrolysis' formula milk or appropriate hydrolyzed formulas milk powder is fed, the therapeutic intervention time is with 3-12 It is advisable within a month.Amino acid formula milk is the antigenicity that milk protein is reduced to protein component by special processing, makes its end Product is oligopeptides, has avoided the antigenicity of milk protein, and the fat containing normal amount and carbohydrate, nutrition completely It is still constant, it is mainly used for the treatment of middle severe milk allergy infant；Depth hydrolysis' formula milk is to be by milk protein hydrolysate Short peptide chain significantly reduces the antigenicity of lactalbumin and casein, is mainly used for the treatment of light moderate milk allergy infant；Part The milk protein of hydrolyzed formulas milk powder is small peptide fragment, and hydrolysis degree is relatively low, and there are still incomplete antigen activity, are mainly used for preventing morning The development of phase allergy and reduction allergy risk.
The method for the treatment of food hypersenstivity is to eliminate allergen and food preparation under a cloud in diet, is often referred in food Protein, this be treat food hypersenstivity basis.Therefore, for the baby children for the milk allergy for being unable to get abundant breast-feeding Youngster needs to substitute dairy products based on depth hydrolysis' albumen or amino acid formula.But hydrolyzing lactoalbumin formula currently on the market Powder huge number, the degree of hydrolysis and peptide chain distribution situation for hydrolyzing lactoalbumin are irregular, give food protein allergy crowd Bring some potential safety problems.
Chinese invention CN106072530A discloses a kind of anti-protein allergies full nutrition formula food, is formulated in albumen Except matter, fat and carbohydrate, essential vitamin and minerals, added ferment powder, probiotics and prebiotic component, Although it improves absorption problem of the protein allergy baby to protein, it is suitable that it is not directed to protein allergy baby addition The special dietary substance of conjunction is to help baby to improve body quality, Reduce allergy symptom.
Therefore, developing prevents food protein allergy crowd from allergic reaction occurs, and can be according to needed for protein allergy crowd Clinical nutrition feature, improve body quality, enhancing immune function, Reduce allergy symptom product, there is important value and wide Wealthy market.
Invention content
The purpose of the present invention is to overcome the defects in the prior art, provides a kind of protein allergy tailored version clinical nutrition Formula and preparation method thereof, the clinical nutrition feature needed for protein allergy crowd provide three balanced big nutrients Matter also contains multivitamin and minerals, provides the nutrition of high quality, can improve body quality, enhancing immune function, delay Solve allergic symptom；And give enteral battalion using hydrolyzed formulas milk powder such as depth hydrolysis' lactalbumin, appropriate hydrolyzing lactoalbumins It supports and supports, prevent food protein allergy crowd from allergic reaction occurs.
To achieve the above object, the present invention adopts the following technical scheme that：
The first purpose of the invention is to provide a kind of protein allergy tailored version clinical nutrition formulas, including following component And its parts by weight：15-21 parts of protein and amino acid, 11-15 portions of fat, 52-57 parts of carbohydrate, 3.4-4.2 portions of meals Eat fiber, 1.2-1.8 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.1- 0.3 part of water soluble vitamin, 0.005-0.11 parts of nucleotide, 0.02-0.06 parts of natural plants compounds；
Wherein, the protein includes amino acid and protein peptides；The amino acid includes taurine, and the protein peptides are selected from Depth hydrolysis' lactalbumin, appropriate hydrolyzing lactoalbumin, soy peptide powder, soybean oligopeptide, wheat protein peptide, pupa albumen peptide, At least one of ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide；
Wherein, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 15~20：25~35：50 ~55.
In order to advanced optimize above-mentioned technical proposal, the technical measures that the present invention is taken further include：
Further, the protein peptides include in depth hydrolysis' lactalbumin, appropriate hydrolyzing lactoalbumin, soy peptide powder It is at least one.
Further, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 17： 30：53.
Further, the parts by weight of the taurine are 0.3-0.6 parts；Further, the weight of the taurine Number is 0.36 part.
Further, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO knots At least one of structure fat, DHA, EPA, ARA, phosphatide.Further, the fat includes docosahexaenoic acid and peanut Tetraenoic acid, the weight ratio that the docosahexaenoic acid accounts for total fat is 1%~2%, and the arachidonic acid accounts for total fat Weight ratio be 0.4%~2.4%；Further, the weight ratio that the docosahexaenoic acid accounts for total fat is 1% ~1.5%, the weight ratio that the arachidonic acid accounts for total fat is 0.4%~1%.
Further, in the fat, the ratio of ω -6 unsaturated fatty acids and omega-3 unsaturated fatty acid is 3~6：1 ~2；Further, the ratio of ω -6 unsaturated fatty acids and omega-3 unsaturated fatty acid is 4：1.
Further, the carbohydrate is selected from least one of maltodextrin, tapioca, resistant starch.
Further, the dietary fiber is selected from inulin, konjaku flour, galactooligosaccharide, oligofructose, oligomeric different malt At least one of sugar, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber.
Further, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, calcium carbonate, potassium chloride, chlorine Change at least one of sodium, magnesium carbonate, magnesium sulfate, K-IAO, sodium citrate and magnesium gluconate.
Further, the trace element is selected from ferrous gluconate, ferric pyrophosphate, potassium iodide, zinc gluconate, sub- selenium At least one of sour sodium, copper gluconate, copper sulphate, manganese sulfate, chromium chloride, chromium sulfate, manganese gluconate and sodium molybdate.
Further, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, dimension life Plain K1At least one of.
Further, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one of plain C, pantothenic acid, folic acid, niacin, choline, inositol, biotin.
Further, the parts by weight of the nucleotide are 0.11-1.2 parts；Further, the weight of the nucleotide Number is 0.11 part；Further, the nucleotide is 5'Monophosphate cytidine.
Further, the natural plants compound is selected from l-cn, Glucosamine, oligofructose, lutein, plant At least one of object sterol, lycopene, resveratrol, allicin；More preferably l-cn.
Further, the protein allergy tailored version clinical nutrition formula further includes 0.1-1 parts of integration of drinking and medicinal herbs ingredients, institute Integration of drinking and medicinal herbs ingredient is stated in hawthorn, the membrane of a chicken's gizzard, mulberries, matrimony vine, fructus alpiniae oxyphyllae, Chinese yam, Poria cocos, malt, honey, jujube extremely Few one kind；Further, the integration of drinking and medicinal herbs ingredient is hawthorn, the membrane of a chicken's gizzard, Chinese yam, Poria cocos, honey.
Further, the protein allergy tailored version clinical nutrition formula further includes 0.1-1 parts of diet essence, the meals Essence is eaten in cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fish and shrimp, poultry meat, fruits It is at least one；Wherein, the greengrocery includes carrot meal, onion powder, garlic powder, cabbage powder, and the Homonemeae includes needle mushroom Powder, the fruits include citrus powder, apple powder.
Second object of the present invention is to provide a kind of dry method work of above-mentioned protein allergy tailored version clinical nutrition formula The preparation method of skill, includes the following steps：
Step 1, powder fat is prepared；
Step 2, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the fat-soluble dimension of predetermined weight number Raw element is used as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous under high pressure Time is 10~15min, then carries out instantaneous drying of spraying, liposoluble vitamin powder is prepared with 60~80 mesh screenings；It will be pre- The water soluble vitamin of parts by weight is determined as core material, is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, sprays wink When dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
Step 3, by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, Trace element, natural plants compound are prepared into the powder that grain size is 150~250 μm respectively；
Step 4, the mixing machine that the powder obtained by step 1~3 is sequentially added to cone-type mixer or other forms mixes Uniformly obtained formula mixture, it is spare after sterilization processing；
Step 5, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution At least one of；
Wherein, the sequence of step 1~3 can be replaced mutually.
Further, powder fat is prepared in the step 1 to specifically comprise the following steps：
1) wall material aqueous solution is prepared：Take maltodextrin 273g, octenyl succinic acid starch 44g, lactalbumin 186g, diet Fiber 80g, water 1L are stirred evenly；It can be heated while stirring when having ready conditions to 60 DEG C, keep 30 minutes postcoolings to room temperature；
2) monoglyceride is taken into 1.17g (a concentration of 0.2%) of total solid is uniformly dissolved in 15.6mL mixed plant greases；Institute State mixed plant grease by 3mL olive oil, 6mL soybean oils, 3mL coconut oil, 0.8mL perilla herb oils, 2.5mL medium chain triglycerides, 0.2mL docosahexaenoic acid greases, 0.1mL arachidonic acid oils composition；
3) Tween 80 is taken into 1.17g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
4) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed, obtains mixed solution；
5) addition stabilizer agar takes 1.17g (a concentration of 0.2%) of total solid after the mixed solution, with water constant volume To 200mL, (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion under 20000r/min；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, is collected To powder fat.
Further, can also include the following steps between the step 3 and step 4：
Prepare integration of drinking and medicinal herbs component powders：The raw material of predetermined weight number is crushed using pulverizer, by crushing Raw material is placed in container, be added weight be raw material weight 3~8 times of water, carry out immersion 3~4 hours, then to soak into Row decocts 30~60min, and filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved and made with 60~80 mesh Standby integration of drinking and medicinal herbs component powders.The step can mutually be replaced with the sequence of step 1~3.
Prepare diet essence powder：By carrot, onion, garlic, cabbage, needle mushroom, citrus, apple respectively using mashing Machine breaks into mixing after juice, crosses 120 mesh sieve, is added after resistant starch, isomalto-oligosaccharide fully by the 20~30% of reduction of feed volume Stirring and dissolving obtains mixed serum, at homogenization pressure 25MPa, to mixed serum homogeneous 3 times, and 5 minutes every time, then to homogeneous Liquid sterilize and is dried using press spray drier, and diet essence powder is prepared with the screening of 80~100 mesh. The step can mutually be replaced with the sequence of step 1~3.
Wherein, optionally increase suitable food thickening agent and food additives in the step 5.The food increases Thick dose in guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum at least one Kind；The food additives are selected from least one of Aspartame, food flavor fragrance, brown sugar.More preferably carragheen, Ah Draw primary glue, guar gum, Aspartame, food flavor fragrance.
Further, the operation step of the preparation method of the dry process of above-mentioned protein allergy tailored version clinical nutrition formula Suddenly it is both needed to carry out under the protection of inert gas, used inert gas is nitrogen, argon gas, helium etc..In inert gas The lower progress aforesaid operations step of protection can prevent the danger of powder explosion.
In addition, the present invention also provides a kind of preparations of the wet processing of above-mentioned protein allergy tailored version clinical nutrition formula Method includes the following steps：
Step 1, by the protein of predetermined weight number and amino acid, fat, carbohydrate, dietary fiber, constant member Element, trace element, liposoluble vitamin, water soluble vitamin, nucleotide, natural plants compound are pressed in the water of predetermined amount It according to the physical behavior of raw material, adds according to sequencing, is stirred while addition successively, the mixing breast of raw material is made Liquid；
Step 2, mixed emulsion step 1 obtained carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
Step 3, the concentrate that step 2 obtains is spray-dried, is sieved, is prepared into powder, is prepared by the powder At at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution.
In the present invention using include hawthorn, the membrane of a chicken's gizzard, Chinese yam, Poria cocos, honey integration of drinking and medicinal herbs ingredient, mentioned component compatibility After synergy have stomach strengthening and digestion promoting, enhancing body resistance against diseases the benefits of, which improve conventional nutraceutical formula often make baby generate flatulence, It the digestive problems such as is not easy to absorb, peomotes the absorption of each nutriment in nutrient formulation, enhance baby's constitution, accelerate baby children The growth and development of youngster.
Hawthorn can promote gastric secretion to help digest, and have good functions of strengthening stomach and promoting digestion；The lipolytic enzyme contained in hawthorn There is good digestion for the food of fats, can effectively promote the secretion of gastric juice in body, improve digestible energy Power；
The membrane of a chicken's gizzard has effects that food digesting stomach fortifying, and can be with invigorating the spleen and stomach, with hawthorn with can further enhance digestion-promoting Long-pending effect；
Chinese yam is conducive to taste digestion and absorption function, and it is the work of glucose that the amylase contained by Chinese yam, which has hydrolysis starch, With directly capable of providing thermal energy for brain, play an important roll to brain tonic；Nutritive yam is abundant simultaneously, has enhancing nerve thin Cytoactive, bushing gas, tranquilizing mind control forgetful, nourishing heart intelligence development, enhance memory function；
Poria cocos can increase the cytotoxic effect of macrophage, increase nonspecific acid esterase positive lymphocyte number, Enhance the cytotoxicity of T lymphocytes, mouse serum complement number can be remarkably reinforced in methylol pachymaran and special Antigen-binding cells number, have the function of enhance body's immunity；
Honey is regarded as a kind of food and drug full of nutrition since ancient times, there is anti-inflammatory, eliminating the phlegm, moistening lung, cough-relieving The effect of, it takes for a long time, the breaking-out of asthma can also be alleviated；Honey can also be pre- hypo-allergenic simultaneously；Also contain inside honey Micro bee venom, it is a kind of toxic liquid in honeybee body, and bee venom has corticotropin sample effect, can improve human body Interior ambient condition adjusts immunity of organisms, has the function of antiallergy, radioresistance, enhancing body resistance against diseases.
In the present invention using include carrot, onion, needle mushroom, garlic, citrus, cabbage, apple diet essential ingredient, There is the benefits of Reduce allergy symptom, prevention of inflammation after mentioned component compatibility synergy, may go out for protein allergy infant Existing allergic symptom plays effective prevention and mitigation, improves the body quality of baby, contribute to the growth of baby Development.
Contain a large amount of anti-inflammatory, antiallergy substance in carrot, onion, needle mushroom, garlic, it being capable of effective pre- pollen-proof The allergic reactions such as allergy, allergic dermatitis；
Citrus can reconcile stomach, and stimulating intestine and stomach is wriggled, and helps to be vented, moreover it is possible to which calm alimentary canal increases appetite, stimulation food It is intended to；Vitamin C is rich in citrus, vitamin C can inhibit the generation of histamine in vivo, and can improve capillary permeability, The exudation for reducing tissue fluid, to Reduce allergy symptom；
The Quercetin that cabbage is rich in can effectively prevent allergy and asthma, have anti-inflammatory and antihistamine characteristic；Flower simultaneously Cabbage sprout contains abundant sulforaphane, is a kind of potent anti-inflammatory compound, has in terms of stimulating Antioxidation reaction Apparent biological effect, the quantity that the cauliflower sprout of test dose can result in glutathione sulfydryl transferase doubles, this Enzyme plays the role of antioxidant in human body, being capable of effective prevention of asthma, allergy and chronic obstructive pulmonary disease；
The Quercetin that apple is rich in can effectively prevent allergy and asthma, have anti-inflammatory and antihistamine characteristic；In apple Polyphenol can by mitigate allergy mouse ear swelling and atopy patient scytitis by inhibition is played to histamine Effect, contributes to the alleviation of protein allergy symptom.
The present invention is had the following technical effect that compared with prior art using above-mentioned technical proposal：
1) protein allergy tailored version clinical nutrition formula of the invention uses depth hydrolysis' albumen, and depth hydrolysis' albumen is not Only dissolubility is good, and digestibility is high, acidproof, heat-resisting, equally also has a variety of physiological regulation functions, as blood pressure lowering, drop courage are solid Alcohol, antibacterial, anticancer etc., albumen are superfine small segment by depth hydrolysis, significantly reduce the anaphylactoid risk of triggering, mainly Treatment for light moderate milk allergy infant；Using appropriate hydrolyzing lactoalbumin, albumen is moderately hydrolyzed to small peptide fragment, mainly Development for preventing early stage allergy and reduction allergy risk.
2) present invention addition 4:1 ω -6 unsaturated fatty acids and omega-3 unsaturated fatty acid, polyunsaturated fatty acid close Reason proportioning, participates in phosphatide synthesis, cholesterol metabolic, the reparation of injury tissue, the growth of cambium, protects the skin from ray Damage, plays an important roll brain, nerve fiber and retinal development, participates in hormone sensitive lipase gene, has protection to angiocardiopathy Effect.
3) docosahexaenoic acid and arachidonic acid of present invention addition rational proportion, in the growth and development of baby, Polyunsaturated fat has important structure and function, such as arachidonic acid (C20-4, n-6, ARA) and DHA, they are in breast milk In it is naturally occurring in phospholipid form；ARA and DHA has actively impact to the development of brain and newborn's retina；In adult, ARA and DHA can be synthesized by linoleic acid and alpha-linolenic acid, but the synthesis capability of baby is limited；DHA and ARA is from utero to going out Continue to increase in baby's forebrain within 2 years old after life, is accumulated in fetal brain since 26th week pregnant, to 3 months thirds trimester of pregnancy In continue；Since 1 years old~3 years old child is in the peak period of growth and development, add DHA and ARA, for infant's intelligence and The development of physique is particularly important.
4) 0.11-1.2 parts of nucleotide of present invention addition, it is possible to reduce the generation of diarrhea, while increasing immunity of organisms, make Fat, trace element are more easy to absorb.
5) present invention strengthens 0.3-0.6 parts of taurine, and the entitled 2-aminoethanesulfonic acid of taurine chemistry is cysteine through de- Sulphur is simultaneously oxidized to sulfonate radical and a kind of derivative beta-amino sulfonic acid by carboxyl；The biological action of taurine includes combining bile Normal development etc. that is sour, anti-oxidant and participating in brain and retina.
Nutrient refers to providing energy to human body in food, participating in body composition and the chemical composition of regulation of physiological functions, Nutrition necessary to human body is known as protein, lipid, carbohydrate, minerals, vitamin, water, dietary fiber etc..The albumen of the present invention Matter allergy tailored version clinical nutrition formula not only contains balanced three major nutrient, also contains multivitamin and minerals, It is capable of providing high quality nutrition, enhances immune function, and using water such as depth hydrolysis' lactalbumin, appropriate hydrolyzing lactoalbumins Solution formula milk gives EN support, is free of lactose, removes milk protein anaphylactogen, prevents food protein allergy crowd from sending out Raw allergic reaction is protein allergy crowd, and comprehensively sufficient nutrition branch is provided especially for the infant of protein allergy It holds, promotes the growth and development of infant.
The present invention is added by selecting the basal nutrient element of rational proportion with stomach strengthening and digestion promoting, enhancing body disease-resistant The spies such as ability, Reduce allergy symptom, the dietary fiber of prevention of inflammation, natural plants compound, integration of drinking and medicinal herbs ingredient, diet essence Different nutriment, and adjust its proportioning and carry out compatibility synergy with basal nutrient element, the protein allergy tailored version of the present invention made Clinical nutrition formula is easier to be absorbed by protein allergy crowd, the effect of to give full play to each component, according to protein mistake Clinical nutrition feature needed for quick crowd, the especially infant of protein allergy provide the nutritional support of comprehensive abundance for it, Promote intelligence and anthropometic, improve body quality, Reduce allergy symptom.
Specific implementation mode
The present invention provides a kind of protein allergy tailored version clinical nutrition formulas comprising following component and its parts by weight Number：15-21 parts of protein and amino acid, 11-15 parts of fat, 52-57 parts of carbohydrate, 3.4-4.2 parts of dietary fibers, 1.2-1.8 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.1-0.3 parts it is water-soluble Property vitamin, 0.005-0.11 parts of nucleotide, 0.02-0.06 parts of natural plants compounds；
Wherein, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 15~20：25~35：50 ~55；
Wherein, the protein includes amino acid and protein peptides；The amino acid includes taurine, and the protein peptides are selected from Depth hydrolysis' lactalbumin, appropriate hydrolyzing lactoalbumin, soy peptide powder, soybean oligopeptide, wheat protein peptide, pupa albumen peptide, At least one of ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide.
With reference to embodiment, the specific embodiment of the present invention is further described.Following embodiment is only used for more Add and clearly demonstrate technical scheme of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
Protein allergy tailored version clinical nutrition formula of the present invention includes depth hydrolysis' PURE WHEY 20.02g, soy peptide powder 0.5g, taurine 0.36g；Nucleotide 0.11g；Olive oil 2.67g, soybean oil 5.35g, coconut oil 2.67g, perilla herb oil 0.76g, medium chain triglyceride 2.29g, docosahexaenoic acid grease 0.18g, arachidonic acid oil 0.064g；Maltodextrin 56.75g；Dietary fiber 3.66g；Calcium 0.51g, phosphorus 0.272g, potassium 0.485g, sodium in macroelement 0.291g, magnesium 0.157g；Iron 0.011g, zinc 0.007g, iodine 0.042mg, selenium 0.015mg, copper 0.154mg, manganese in trace element 0.18mg；Vitamin A 0.0007g, vitamin D30.0068mg, vitamin E 0.009g, vitamin K10.045mg；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12It is 0.0018mg, vitamin C 0.142g, general Sour 0.003g, folic acid 0.036mg, niacin 0.0027g, choline 0.055g, inositol 0.036g；L-cn 0.036g.
Embodiment 2
Protein allergy tailored version clinical nutrition formula of the present invention includes appropriate hydrolyzing lactoalbumin powder 20.02g, soy peptide powder 0.5g, taurine 0.36g；Nucleotide 0.11g；Olive oil 2.67g, soybean oil 5.35g, coconut oil 2.67g, perilla herb oil 0.76g, medium chain triglyceride 2.29g, docosahexaenoic acid grease 0.18g, arachidonic acid oil 0.064g；Maltodextrin 56.75g；Dietary fiber 3.66g；Calcium 0.51g, phosphorus 0.272g, potassium 0.485g, sodium in macroelement 0.291g, magnesium 0.157g；Iron 0.011g, zinc 0.007g, iodine 0.042mg, selenium 0.015mg, copper 0.154mg, manganese in trace element 0.18mg；Vitamin A 0.0007g, vitamin D30.0068mg, vitamin E 0.009g, vitamin K10.045mg；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12It is 0.0018mg, vitamin C 0.142g, general Sour 0.003g, folic acid 0.036mg, niacin 0.0027g, choline 0.055g, inositol 0.036g；L-cn 0.036g.
Embodiment 3
Protein allergy tailored version clinical nutrition formula of the present invention includes soy peptide powder 20.52g, taurine 0.36g；Nucleotide 0.11g, olive oil 2.67g, soybean oil 5.35g, coconut oil 2.67g, perilla herb oil 0.76g, medium chain triglyceride three Ester 2.29g, docosahexaenoic acid grease 0.18g, arachidonic acid oil 0.064g；Maltodextrin 56.75g；Dietary fiber 3.66g；Calcium 0.51g, phosphorus 0.272g, potassium 0.485g, sodium 0.291g, magnesium 0.157g in macroelement；Iron in trace element 0.011g, zinc 0.007g, iodine 0.042mg, selenium 0.015mg, copper 0.154mg, manganese 0.18mg；Vitamin A 0.0007g, vitamin D30.0068mg, vitamin E 0.009g, vitamin K10.045mg；Vitamin B10.001g, vitamin B20.001g, dimension Raw element B60.001g, vitamin B120.0018mg, vitamin C 0.142g, pantothenic acid 0.003g, folic acid 0.036mg, niacin 0.0027g, choline 0.055g, inositol 0.036g；L-cn 0.036g.
Embodiment 4
Protein allergy tailored version clinical nutrition formula of the present invention includes depth hydrolysis' PURE WHEY 20.02g, soy peptide powder 0.5g, taurine 0.36g；Nucleotide 0.11g, olive oil 2.67g, soybean oil 5.35g, coconut oil 2.67g, perilla herb oil 0.76g, medium chain triglyceride 2.29g, docosahexaenoic acid grease 0.18g, arachidonic acid oil 0.064g；Maltodextrin 56.75g；Dietary fiber 3.66g；Calcium 0.51g, phosphorus 0.272g, potassium 0.485g, sodium in macroelement 0.291g, magnesium 0.157g；Iron 0.011g, zinc 0.007g, iodine 0.042mg, selenium 0.015mg, copper 0.154mg, manganese in trace element 0.18mg；Vitamin A 0.0007g, vitamin D30.0068mg, vitamin E 0.009g, vitamin K10.045mg；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12It is 0.0018mg, vitamin C 0.142g, general Sour 0.003g, folic acid 0.036mg, niacin 0.0027g, choline 0.055g, inositol 0.036g；L-cn 0.036g；Hawthorn 0.1g, the membrane of a chicken's gizzard 0.1g, Chinese yam 0.1g, Poria cocos 0.1g, honey 0.1g；Carrot meal 0.1g, onion powder 0.1g, garlic powder 0.1g, Cabbage powder 0.1g, golden needle fungus 0.1g, citrus powder 0.1g, apple powder 0.1g.
Embodiment 5
Protein allergy tailored version clinical nutrition formula of the present invention includes depth ocean fish oligopeptide powder 20.02g, soybean oligopeptide 0.5g, taurine 0.36g；Nucleotide 0.11g；Olive oil 2.67g, soybean oil 5.35g, coconut oil 2.67g, perilla herb oil 0.76g, medium chain triglyceride 2.29g, docosahexaenoic acid grease 0.18g, arachidonic acid oil 0.064g；Maltodextrin 56.75g；Dietary fiber 3.66g；Calcium 0.51g, phosphorus 0.272g, potassium 0.485g, sodium in macroelement 0.291g, magnesium 0.157g；Iron 0.011g, zinc 0.007g, iodine 0.042mg, selenium 0.015mg, copper 0.154mg, manganese in trace element 0.18mg；Vitamin A 0.0007g, vitamin D30.0068mg, vitamin E 0.009g, vitamin K10.045mg；Vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B12It is 0.0018mg, vitamin C 0.142g, general Sour 0.003g, folic acid 0.036mg, niacin 0.0027g, choline 0.055g, inositol 0.036g；L-cn 0.036g.
Embodiment 6
A kind of preparation method of protein allergy tailored version clinical nutrition formula as described in 1~embodiment of embodiment 5 is such as Under：
1) powdered oil (powder fat) is prepared：
A) wall material aqueous solution is prepared：Take maltodextrin 273g, octenyl succinic acid starch 44g, lactalbumin 186g, meals Food fiber 80g, water 1L are stirred evenly and (are had ready conditions and heat while stirring to 60 DEG C, keep 30 minutes postcoolings to room temperature).
B) by monoglyceride take 1.17g (a concentration of 0.2%) of total solid be uniformly dissolved in 15.6mL greases (olive oil 3mL, Soybean oil 6mL, coconut oil 3mL, perilla herb oil 0.8mL, medium chain triglyceride 2.5mL, docosahexaenoic acid grease 0.2mL, flower Raw tetraene acid lipid 0.1mL).
C) Tween 80 is taken into 1.17g (a concentration of 0.2%) of total solid is uniformly dissolved in wall material aqueous solution.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 1.17g (a concentration of 0.2%) of total solid is settled into after mixed solution with water 200mL (a concentration of 25%) of total solid, high speed dispersion 2 minutes under 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).
G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, be added weight be raw material weight 3~8 times of water, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved with 60~80 mesh Prepare integration of drinking and medicinal herbs component powders；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core material, select carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material Mist is instantaneously dried, and liposoluble vitamin powder is prepared with 60~80 mesh screenings；The water soluble vitamin of predetermined weight number is made It for core material, selects maltodextrin, lipoprotein as wall material, is uniformly mixed, spray instantaneous dry, water is prepared with 60~80 mesh screenings Soluble vitamin powder；
4) by the protein of predetermined weight and amino acid, small peptide, nucleotide, carbohydrate, dietary fiber, constant member Element, trace element, natural plants compound are prepared into the powder that grain size is 150~250 μm respectively；
5) mixing machine that the powder obtained by step 1)~step 4) is sequentially added to cone-type mixer or other forms is mixed Uniformly obtained formula mixture is closed, it is spare after sterilization processing；
6) according to conventional technical means by the formula mixture in step 5) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral solution.
In step 6), optionally increase suitable food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, food flavor fragrance, brown sugar；More preferable carragheen, Arabic gum, Guar Glue, Aspartame, food flavor fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 7
The present embodiment is verification embodiment.
This verification embodiment verifies protein allergy tailored version clinical nutrition formula of the present invention to protein allergy The influence of patient.Electuary and following comparative example of the present embodiment using the formula preparation of embodiment 1,4 and 5：
Control group：The full nutritional formula milk powder of the commercially available anti-protein allergies of tradition；
Experimental group 1：The electuary prepared using the nutrient formulation of embodiment 1；
Experimental group 2：The electuary prepared using the nutrient formulation of embodiment 4；
Experimental group 3：The electuary prepared using the nutrient formulation of embodiment 5；
Experimental group 4：The electuary prepared using nucleotide is deleted in the nutrient formulation of embodiment 1；
Experimental group 5：The electuary prepared using diet essence is deleted in the nutrient formulation of embodiment 4；
Experimental group 6：The electuary prepared using integration of drinking and medicinal herbs ingredient is deleted in the nutrient formulation of embodiment 4；
The protein allergy infant 30 of corresponding electuary is voluntarily taken in every group of selection above, and severity extent is similar.Root Above-mentioned electuary is given according to the age and corresponding situation of infant to feed, other diatery supplement etc. are given situation and remained unchanged.Nutrition is dry The pre- time is 3 months total, observes and count the difference of the symptom of digestive tract and curative effect before and after infant nutritional intervention.Experimental result is such as Shown in following table：
Table one is that the symptom of digestive tract of Different Nutrition patients before and after intervention infant compares.
Table two is the comparison of Different Nutrition patients before and after intervention curative effect.The criterion of wherein curative effect is：(1) effective：Nutrition is dry The daily diarrhea of prognosis reduces to two days hereinafter, stool restores, and eczema mitigates, and skin lesion recession area is higher than 80%, clinical manifestation It completely disappears, infant weight obviously increases.(2) effectively：Daily diarrhea number is reduced to less than 4 times after nutritional intervention, and moisture is bright Aobvious to reduce, infant weight is without obviously increasing；Eczema skin lesion area recession 30%-80%, clinical manifestation disappear substantially, infant weight Nothing obviously increases.(3) invalid：Infant symptom of diarrhea is without alleviation after nutritional intervention, and skin lesion area, which subsides, is less than 30%, original clinic Symptom, sign are without improvement, infant weight loss.
The symptom of digestive tract of one Different Nutrition patients before and after intervention infant of table compares (example (%))
As seen from the above table, protein allergy tailored version clinical nutrition formula of the invention, compared to the commercially available anti-albumen of tradition The full nutrient formulation of allergy, after intervening 3 months, the symptom of digestive tract of the vomiting of infant, diarrhea and constipation is significantly improved.Addition Diet essence of the present invention and the experimental result of experimental group of integration of drinking and medicinal herbs ingredient its effect become apparent.
The comparison (example (%)) of the effect of two nutritional intervention time of table
Group Number of cases It is effective Effectively In vain
Control group 30 18 (60.0%) 6 (20.0%) 6 (20.0%)
Experimental group 1 30 21 (70.0%) 7 (23.3%) 2 (6.7%)
Experimental group 2 30 26 (86.7%) 4 (13.3%) 0 (0.0%)
Experimental group 3 30 20 (66.7%) 6 (20.0%) 4 (13.3%)
Experimental group 4 30 22 (73.3%) 6 (20.0%) 2 (6.7%)
Experimental group 5 30 24 (80.0%) 5 (16.7%) 1 (3.3%)
Experimental group 6 30 23 (76.7%) 7 (23.3%) 0 (0.0%)
As seen from the above table, protein allergy tailored version clinical nutrition formula of the invention, compared to the commercially available anti-albumen of tradition The full nutrient formulation of allergy, after intervening 3 months, total effective percentage is significantly improved.Be added to diet essence of the present invention and Its effect of the experimental result of the experimental group of integration of drinking and medicinal herbs ingredient becomes apparent.
By above-described embodiment it is found that protein allergy tailored version clinical nutrition formula of the present invention can be according to egg Clinical nutrition feature needed for white matter allergic human population provides balanced three major nutrient, also contains multivitamin and mineral Matter provides high quality nutrition, enhances immune function；And using water such as depth hydrolysis' lactalbumin, appropriate hydrolyzing lactoalbumins Solution formula milk gives EN support, prevents food protein allergy crowd from allergic reaction occurs.The medicine food that the present invention uses There is the benefits of stomach strengthening and digestion promoting, enhancing body resistance against diseases, which improve conventional nutraceutical formulas often to make after homologous components compatibility synergy Baby such as generates flatulence, is not easy to absorb at the digestive problems, peomotes the absorption of each nutriment in nutrient formulation, enhances baby Constitution accelerates the growth and development of infant；There is Reduce allergy symptom after the diet essence compatibility synergy that the present invention uses, prevent The benefits of inflammation, plays effective prevention and mitigation for the allergic symptom that protein allergy infant is likely to occur, The body quality for improving baby contributes to the growth and development of baby.
Specific embodiments of the present invention are described in detail above, but it is intended only as example, the present invention is simultaneously unlimited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and It substitutes also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by impartial conversion and Modification, all should be contained within the scope of the invention.

Claims (10)

1. a kind of protein allergy tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight： 15-21 parts of protein, 11-15 parts of fat, 52-57 parts of carbohydrate, 3.4-4.2 parts of dietary fibers, 1.2-1.8 parts of constant members Element, 0.01-0.04 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.1-0.3 parts of water soluble vitamins, 0.005- 0.11 part of nucleotide, 0.02-0.06 parts of natural plants compounds；
Wherein, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 15~20：25~35：50~55；
Wherein, the protein includes amino acid and protein peptides；The amino acid includes taurine, and the protein peptides are selected from depth Hydrolyzing lactoalbumin, appropriate hydrolyzing lactoalbumin, soy peptide powder, soybean oligopeptide, wheat protein peptide, pupa albumen peptide, ocean At least one of fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin peptide.
2. a kind of protein allergy tailored version clinical nutrition formula according to claim 1, which is characterized in that the albumen Peptide includes at least one of depth hydrolysis' lactalbumin, appropriate hydrolyzing lactoalbumin, soy peptide powder.
3. a kind of protein allergy tailored version clinical nutrition formula according to claim 1, which is characterized in that the nutrition In formula, protein：Fat：The productivity ratio of carbohydrate is 17：30：53.
4. a kind of protein allergy tailored version clinical nutrition formula according to claim 1, which is characterized in that the fat In, the ratio of ω -6 unsaturated fatty acids and omega-3 unsaturated fatty acid is 3~6：1~2.
5. a kind of protein allergy tailored version clinical nutrition formula according to claim 1, which is characterized in that the fat Including docosahexaenoic acid and arachidonic acid, weight ratio that the docosahexaenoic acid accounts for total fat is 1%~ 2%, the weight ratio that the arachidonic acid accounts for total fat is 0.4%~2.4%.
6. a kind of protein allergy tailored version clinical nutrition formula according to claim 1, which is characterized in that the nucleosides The parts by weight of acid are 0.11-1.2 parts.
7. a kind of protein allergy tailored version clinical nutrition formula according to claim 1, which is characterized in that further include 0.1-1 parts of integration of drinking and medicinal herbs ingredients, the integration of drinking and medicinal herbs ingredient are selected from hawthorn, the membrane of a chicken's gizzard, mulberries, matrimony vine, fructus alpiniae oxyphyllae, Chinese yam, Fu At least one of Siberian cocklebur, malt, honey, jujube.
8. a kind of protein allergy tailored version clinical nutrition formula according to claim 1, which is characterized in that further include 0.1-1 parts of diet essence, the diet essence are selected from cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；Wherein, the greengrocery includes carrot meal, onion powder, garlic powder, cabbage Powder, the Homonemeae include golden needle fungus, and the fruits include citrus powder, apple powder.
9. the preparation method of the protein allergy tailored version clinical nutrition formula according to any one of claim 1-8, It is characterized in that, includes the following steps：
Step 1, powder fat is prepared；
Step 2, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the liposoluble vitamin of predetermined weight number It as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous time under high pressure For 10~15min, instantaneous drying of spraying then is carried out, liposoluble vitamin powder is prepared with 60~80 mesh screenings；By predetermined weight The water soluble vitamin of number is measured as core material, selects maltodextrin, lipoprotein as wall material, is uniformly mixed, spray instantaneous dry It is dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
Step 3, by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, micro Element, natural plants compound are prepared into the powder that grain size is 150~250 μm respectively；
Step 4, the powder obtained by step 1~3 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, by sterilization It is spare after processing；
Step 5, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution It is at least one；
Wherein, the sequence of step 1~3 can be replaced mutually.
10. preparation method according to claim 9, which is characterized in that prepare powder fat in the step 1 and specifically include Following steps：
1) wall material aqueous solution is prepared：Take maltodextrin 273g, octenyl succinic acid starch 44g, lactalbumin 186g, dietary fiber 80g, water 1L are stirred evenly；
2) monoglyceride is taken into 1.17g (a concentration of 0.2%) of total solid is uniformly dissolved in 15.6mL mixed plant greases；It is described mixed Vegetable fat is closed by 3mL olive oil, 6mL soybean oils, 3mL coconut oil, 0.8mL perilla herb oils, 2.5mL medium chain triglycerides, 0.2mL Docosahexaenoic acid grease, 0.1mL arachidonic acid oils composition；
3) Tween 80 is taken into 1.17g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
4) the mixed plant grease and the wall material aqueous solution of addition Over emulsfication agent Tween 80 that add Over emulsfication agent monoglyceride is abundant Mixing, obtains mixed solution；
5) (a concentration of 0.2%) of total solid is settled to after the mixed solution with water addition stabilizer agar 1.17g (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion to 200mL under 20000r/min；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, and collection obtains powder Last fat.
CN201810445032.0A 2018-05-10 2018-05-10 Protein allergy tailored version clinical nutrition formula and preparation method thereof Pending CN108703365A (en)

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