CN108651988A - Nephrosis dialysis tailored version clinical nutrition formula and preparation method thereof - Google Patents

Nephrosis dialysis tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN108651988A
CN108651988A CN201810444527.1A CN201810444527A CN108651988A CN 108651988 A CN108651988 A CN 108651988A CN 201810444527 A CN201810444527 A CN 201810444527A CN 108651988 A CN108651988 A CN 108651988A
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powder
parts
nephrosis
fat
clinical nutrition
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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Abstract

The present invention provides a kind of nephrosis dialysis tailored version clinical nutrition formula, including following component and its parts by weight：15 25 parts of protein, 8 12 parts of fat, 50 54 parts of carbohydrate, 35 parts of dietary fibers, 0.3 0.6 parts of macroelements, 0.01 0.05 parts of trace elements, 0.005 0.02 parts of liposoluble vitamins, 0.01 0.2 parts of water soluble vitamins, 0.05 1 parts of diet essence, 0.05 2 parts of integration of drinking and medicinal herbs ingredients, 0.1 3 parts of natural plants compounds and 0.005 2 parts of new resource foods；The present invention also provides the preparation methods of above-mentioned clinical nutrition formula.The present invention can provide balanced nutriment for nephrosis dialysis patient, can keep the stabilization of patient body quality, booster immunization responsibility, repair function, the state that reduces inflammation, improve oxygen radical removing ability and inner skin cell function.

Description

Nephrosis dialysis tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to nutrient formulation field more particularly to a kind of nephrosis dialysis tailored version clinical nutrition formula and its preparations Method.
Background technology
Kidney is the vitals for having in human body excretion, metabolism and endocrine function, it can be each histoorgan of human body Generated various metabolites, the especially metabolic waste of protein, are excreted by urine in metabolic process, with dimension Hold the balance of human body water, electrolyte and soda acid.Therefore, kidney is to having very important effect body metabolism.
Kidney failure refers to the pathological state that renal function is partly or entirely lost, and kidney failure can be divided into acute renal failure and slow Property kidney failure, the disease progression of acute renal failure is quick, typically because of renal blood flow insufficient (such as wound or burn), kidney Function is impaired caused by certain factor is blocked or is injured by poisonous substance, and the generation of acute renal failure is caused；Chronic renal failure Main cause is long-term renal lesions, and with the progress of time and disease, the function of kidney is gradually reduced, and causes kidney failure Occur.
The state of an illness of acute renal failure is critical, and the death rate is high, and curative effect is slower if imposing liquid expectant treatment merely, with The progress at full speed of modern medicine, haemodialysis are a kind of partial alternative renal functions, race against time for kidney reparation and regeneration Important measures just like have become the basic hand of most of acute nephropathy patient treatments with the popularization and promotion of dialysis Section；Hemodialysis is carried out as early as possible for the patient of acute renal failure, can prevent and reduce patient's multiple organ failure And the generation of other severe complications.The advantages of haemodialysis, mainly has：The patient overweight to volume load can remove it in vivo Excessive moisture；Remove the toxin such as creatinine, urea nitrogen；Patient's potassemia and metabolic acidosis are corrected to stablize patient's body Interior environment；Contribute to the intake of liquid, heat, protein and other nutriments；It can also will be infectious caused by protopathy Inflammatory mediator, such as：Interleukins, tumor necrosis factor give in vitro；Be conducive to the reparation and regeneration of injury of kidney cell.So And due to various reasons, in dialysis patient, 23%~76% has malnutrition, wherein 6%~8% patient has serious nutrition It is bad.One of an important factor for malnutrition is these patients ' life qualities of influence and prognosis at a specified future date.Malnutrition can make dialysis The immune function of patient reduces, aggravation of anemia and is easy to infect, and influences the organ dysfunctions such as the heart, lung, brain, makes patients ' life quality It reduces, case fatality rate increases.
As China gradually steps into aging society, the health problem of mid-aged population is increasingly becoming society and clinical concern Focus, susceptible disease disease of the chronic renal failure as the middle-aged and the old seriously affected the health and quality of life of patient, when Preceding majority person in middle and old age's patients with chronic renal failure is sustained life using the mode of haemodialysis.Haemodialysis is clinically to be used to treat A kind of conventional therapy of chronic renal failure can replace renal function, by blood drainage to haemodialysis control unit, carry out blood With the mass exchange of dialyzate, to achieve the effect that remove patient's body excess moisture metabolite, maintain Water-Electrolyte and Acid-base balance.However, according to incompletely statistics, there is malnutritive symptom, wherein severe malnutrition person very in about 5 one-tenth dialysis patients To accounting for 20%~30%, the health of patient is seriously threatened, influences its quality of life.Therefore, how before ensuring curative effect It puts to improve and also becomes the hot issue that each scholar probes into using person in middle and old age's patients with chronic renal failure nutritional status of haemodialysis. With going deep into for correlative study, some scholars point out that maintenance hemodialysis (MHD) can effectively make up conventional hemodialysis drawback, To promoting patient's prognosis promotion and Prognosis that there is actively impact.
Correlative study shows malnutritive one of the common complication as haemodialysis, seriously affects minimal invasive treatment's matter Amount, some scholars are discussed with regard to its risk factor, it is found that the age is the increased risk for threatening patient malnutritive symptom occur One of factor prompts clinic that person in middle and old age's Chronic Renal Failure Patients should be classified as to emphasis monitoring and early intervention object, carries out related drink Food and nutritional intervention work reduce its malnutritive occurrence risk, General Promotion patient's prognostic level with this.
Therefore, periodically to dialysis patient, especially person in middle and old age's Chronic Renal Failure Patients, carry out Nutrition Evaluation be follow-up of patients and The leading indicator of monitoring.It is worth noting that physical presence two kinds of malnutrition in dialysis patient：I type nutrition is not Good, also referred to as simple malnutritive, i.e., its malnutrition is mainly because protein and Energy intaking deficiency cause, while dialysing not Fully, metabolic acidosis causes body catabolism to enhance, and malnutrition can be further aggravated, and this type of malnutrition serum is white Protein level is normal or reduces, and is often improved by reinforcing dialysis and extra-nutrition；II type malnutrition mainly has with inflammation It closes, passes through inflammatory mediator and cell factor C reactive protein, amyloid A, interleukin 1, interleukin-6, tumour The release of necrosin a etc. causes malnutrition, although malnutrition can still occur for this type of fully dialysis.Wherein, C- reacts egg It is used as a kind of acute phase reactive protein in vain, is the reliable reflection of internal level of inflammation, by widely as the mark of inflammatory reaction.
The incidence of the annual end-stage renal disease in China is more than 10/,100,000 populations, and is increased with annual 18% growth rate It is long.Although the technology of dialysis is constantly progressive, the time-to-live of dialysis patient is also constantly extending, and still has 20% renal failure every year Patient is exhausted to die of illness.Since one of the main reason for influencing the high case fatality rate of dialysis patient and complication rate is exactly generally existing Malnutrition, but the enteral nutrition preparation for being directed to dialysis patient currently on the market is seldom, therefore solve dialysis patient nutrition not Good specific full nutrition enteral nutrition preparation is extremely urgent.
Acute renal failure (Acute Renal Failure, ARF) is a kind of clinical syndrome with high mortality, Prognosis and the general immunity and metabolism status of ARF patient are closely related, and ARF usually causes oxidative stress and inflammatory conditions, nutrition It is bad to aggravate these reactions；In addition, the malnutrition of already present pure is (mainly because of protein before some morbidities Cause with Energy intaking deficiency) or the malnutrition (mainly and inflammation-related) of Nosocomial be regarded as leading to acute kidney An important factor for failure patients' death rate persistently increases.Therefore, ARF patient takes corresponding enteral nutrition system while dialysis Agent can keep the stabilization of body quality, booster immunization responsibility, repair function, the state that reduces inflammation, improve oxygen radical Scavenging activity and inner skin cell function help to reduce nephrosis dialysis patient case fatality rate and complication rate, reduce patient Underfed occurrence risk promotes the prognostic level of patient.
A kind of enteral nutrition preparation and preparation method thereof for dialysis patient disclosed in Chinese patent CN105519961A, Its formula is only added to protein, fat and carbohydrate, although the nutrition and metabolism demand of dialysis patient can be supplemented, But its be directed to the suitable dietary fiber of dialysis patient addition, diet essence, integration of drinking and medicinal herbs ingredient, natural plants compound with And the special dietaries substance such as new resource food, it cannot preferably help nephrosis dialysis patient to improve body quality, it is extensive to accelerate the state of an illness It is multiple.
Therefore, the nutrition and metabolism demand of nephrosis dialysis patient can either be met by developing, and can improve patient body matter Amount accelerates the product that the state of an illness is restored, and has important value and wide market.
Invention content
The purpose of the present invention is to overcome the defects in the prior art, provides a kind of nephrosis dialysis tailored version clinical nutrition and matches Side and preparation method thereof, according to nephrotic, the simple malnutritive or hospital of generally existing obtains during haemodialysis The underfed feature of property is obtained, balanced nutriment is provided, stabilization, the booster immunization response of patient body quality can be kept Ability, repair function, improve oxygen radical removing ability and inner skin cell function at the state that reduces inflammation, and help to reduce kidney Sick dialysis patient case fatality rate and complication rate reduce the underfed occurrence risk of patient, promote the prognostic level of patient.
To achieve the above object, the present invention adopts the following technical scheme that：
The first purpose of the invention is to provide a kind of nephrosis dialyse tailored version clinical nutrition formula, including following component and Its parts by weight：15-25 parts of protein, 8-12 parts of fat, 50-54 parts of carbohydrate, 3-5 parts of dietary fibers, 0.3-0.6 parts Macroelement, 0.01-0.05 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.01-0.2 parts of water soluble vitamins, The new money of 0.05-1 parts of diet essence, 0.05-2 parts of integration of drinking and medicinal herbs ingredients, 0.1-3 parts of natural plants compounds and 0.005-2 parts Source food；
Wherein, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 15~20：20~25：50 ~60.
Wherein, the integration of drinking and medicinal herbs ingredient include Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, campanulaceae, Gorgon fruit, Chinese yam, At least one of hawthorn, Gallus domesticlus brisson, donkey-hide gelatin.
In order to advanced optimize above-mentioned technical proposal, the technical measures that the present invention is taken further include：
Further, protein：Fat：The productivity ratio of carbohydrate is 18.6：24.1：57.3.
Further, the protein includes that lactalbumin, soybean protein isolate, whole milk powder, dried whole-egg, marine fish are low At least one of poly- peptide, colostrum, taurine；Further, the protein be lactalbumin, soybean protein isolate, Whole milk powder, dried whole-egg, ocean fish oligopeptide, colostrum, taurine.
Further, the parts by weight of the fat are 9~11 parts；Further, the parts by weight of the fat are 10.7 parts.
Further, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide.
Further, the fat includes ω -6 unsaturated fatty acids and omega-3 unsaturated fatty acid, wherein ω -6 insatiable hungers It is 4 with the ratio of aliphatic acid and omega-3 unsaturated fatty acid：1.
Further, the fat includes medium chain triglyceride, olive oil, soybean oil, coconut oil, perilla herb oil.
Further, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch In at least two.
Further, the dietary fiber includes inulin, konjaku flour, galactooligosaccharide, oligofructose, oligomeric different malt At least one of sugar, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；Further, the dietary fiber includes At least one of galactooligosaccharide and oligoisomaltose.
Further, the dietary fiber selects water-soluble dietary fiber.
Further, the macroelement includes calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, calcium carbonate, gluconic acid At least one of potassium, potassium chloride, sodium chloride, sodium citrate, magnesium gluconate, magnesium carbonate.
Further, trace element includes ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, gluconic acid At least one of copper, copper sulphate, chromium sulfate, chromium chloride, manganese sulfate, manganese gluconate and sodium molybdate.
Further, the parts by weight of selenium are 0.00001~0.0001 part in the trace element；Further, institute The parts by weight for stating selenium in trace element are 0.00006 part.
Further, the liposoluble vitamin includes vitamin A, beta carotene, vitamin D3, vitamin E, dimension life Plain K1At least one of.
Further, the water soluble vitamin includes vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one of plain C, pantothenic acid, folic acid, niacin, choline, inositol, biotin.
Further, the diet essence includes cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；Wherein, the cereal include rice meal, millet powder, black rice flour, coixlacrymajobi powder, At least one of corn flour, wheat germ powder, oatmeal, buckwheat, the beans include peameal, mung bean flour, black bean powder, At least one of red bean powder, soy meal, the potato are mainly made of common yam rhizome powder, and the greengrocery includes carrot meal, white trailing plants At least one of Bu Fen, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder, the Homonemeae include mushroom powder, sea Band at least one of powder and white fungus powder, the nut-seed class includes at least one of pumpkin seed powder and lotus nut starch, described Fish and shrimp include at least one of salmon powder and cod meal, and the poultry meat includes chicken meal, powdered beef and pig kidney powder At least one of, the fruits include in red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder at least It is a kind of.
Further, the integration of drinking and medicinal herbs ingredient include Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, campanulaceae, Gorgon fruit, At least one of Chinese yam, hawthorn, Gallus domesticlus brisson, donkey-hide gelatin；Further, the integration of drinking and medicinal herbs ingredient is Fermented Soybean, Poria cocos, covers basin Son, matrimony vine, sealwort, campanulaceae, Gorgon fruit, Chinese yam, parts by weight are respectively：0.01-0.1 parts of Fermented Soybean, 0.01-0.1 parts of Poria cocos, 0.01-0.1 parts of raspberry, 0.01-0.1 parts of matrimony vine, 0.01-0.1 parts of sealwort, 0.01-0.1 parts of campanulaceae, 0.01-0.1 parts of Gorgon fruit, 0.01-0.1 parts of Chinese yam；Or the integration of drinking and medicinal herbs ingredient be Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, campanulaceae, Gorgon fruit, Chinese yam, Gallus domesticlus brisson, donkey-hide gelatin, parts by weight are respectively：0.01-0.1 parts of Fermented Soybean, 0.01-0.1 parts of Poria cocos, raspberry 0.01- 0.1 part, 0.01-0.1 parts of matrimony vine, 0.01-0.1 parts of sealwort, 0.01-0.1 parts of campanulaceae, 0.01-0.1 parts of Gorgon fruit, Chinese yam 0.01- 0.1 part, 0.01-0.1 parts of Gallus domesticlus brisson, 0.01-0.1 parts of donkey-hide gelatin.
Further, the natural plants compound includes l-cn, Glucosamine, oligofructose, lutein, plant At least one of object sterol, lycopene, resveratrol, allicin；Further, the natural plants compound is a left side Revolve carnitine.
Further, the new resource food includes milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo In leaf flavones, casein phosphopeptide, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide At least one；Further, the new resource food is avenabeta glucosan.
Further, the nephrosis dialysis tailored version clinical nutrition formula can also include nucleotide, and the nucleotide is 5'- monophosphate cytidines.
Second object of the present invention is to provide a kind of preparation method of above-mentioned nephrosis dialysis tailored version clinical nutrition formula, Include the following steps：
Step 1, powder fat is prepared；
Step 2, integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, it will The raw material of crushing is placed in container, and 3~8 times of the water that weight is raw material weight is added, carries out immersion 3~4 hours, then to leaching Bubble liquid carries out 30~60min of decoction, and filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, with 60~80 mesh Screening prepares integration of drinking and medicinal herbs component powders；
Step 3, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the fat-soluble dimension of predetermined weight number Raw element is used as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous under high pressure Time is 10~15min, then carries out instantaneous drying of spraying, liposoluble vitamin powder is prepared with 60~80 mesh screenings；It will be pre- The water soluble vitamin of parts by weight is determined as core material, is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, sprays wink When dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
Step 4, by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, Trace element, diet essence, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively End；
Step 5, the mixing machine that the powder obtained by step 1~4 is sequentially added to cone-type mixer or other forms mixes Uniformly obtained formula mixture, it is spare after sterilization processing；
Step 6, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution At least one of；
Wherein, the sequence of step 1~4 can be replaced mutually.
Further, powder fat is prepared in the step 1 to specifically comprise the following steps：
1) wall material aqueous solution is prepared：Take maltodextrin 8g, soybean protein isolate 4g, whole-fat milk powder 11g, dietary fiber 2g, Inulin 1.5g, PURE WHEY 5g, oligoisomaltose 0.5g, Arabic gum 0.2g, cornstarch 0.5g, tapioca 2g, Water 50mL is stirred evenly, and can be heated while stirring when having ready conditions to 60 DEG C, keeps 30 minutes postcoolings to room temperature；The diet is fine Dimension is preferably resistant dextrin；
2) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in 10.8mL mixed plant greases；Institute Mixed plant grease is stated by 2mL olive oil, 6.5mL soybean oils, 1.2mL coconut oil, 0.8mL perilla herb oils, 0.3mL medium chain triglycerides three Ester forms；
3) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
4) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed, obtains mixed solution；
5) (a concentration of 0.2%) of total solid is settled to after the mixed solution with water addition stabilizer agar 0.1g (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion to 200mL under 20000r/min；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, is collected To powder fat.
Further, optionally increase suitable food thickening agent and food additives in the step 6.Wherein, The food thickening agent includes guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one of, the food additives include at least one of Aspartame, food flavor fragrance, brown sugar.More preferably For carragheen, Arabic gum, guar gum, Aspartame, food flavor fragrance.
Further, the operating procedure of the preparation method of above-mentioned nephrosis dialysis tailored version clinical nutrition formula is both needed in inertia It is carried out under the protection of gas, used inert gas is nitrogen, argon gas, helium etc..On being carried out under the protection of inert gas The danger of powder explosion can be prevented by stating operating procedure.
Using the integration of drinking and medicinal herbs for including raspberry, Poria cocos, campanulaceae, Fermented Soybean, matrimony vine, sealwort, Gorgon fruit, Chinese yam in the present invention Ingredient has enhancing immunocompetence, improves oxygen radical removing ability, repairs renal function, suppression after mentioned component compatibility synergy The benefits of kidney damage processed, contributes to nephrosis dialysis patient to absorb and supplement the nutrients, is conducive to the recovery of nephrosis dialysis patient.
Raspberry can be effectively improved glycometabolism, to inhibit and slow down diabetic nephropathy lesion；Improve renal blood flow, suppression Kidney damage process processed；
It is rich in main active of the su-fuling as Poria cocos in Poria cocos, aldosterone receptor can be competed in vitro, reverses in vivo Aldosterone effect does not influence aldosterone synthesis；To edematous patient, be conducive to the discharge of urine, restore renal function, eliminates albumen Urine；
Platycodon root polysaccharide can effectively improve anti-fatigue ability, reduce blood urea nitrogen content, increase hepatic glycogen content；
Fermented Soybean mainly contains protein, fat, carbohydrate, vitamin etc., has antithrombase effect, can be used for delaying Intravascular coagulation is solved, renal blood flow is improved, inhibits kidney damage process；
Matrimony vine has the benefits of qi-restoratives strengthening the essence, improve the immunity of the human body；
Siberian solomonseal rhizome polysaccharide has certain Renoprotective Effect, and having for kidney weight/weight value and nephridial tissue MDA levels improves Effect, helps to improve oxygen radical removing ability；
Gorgon fruit also known as chicken head are real, sweet flat help, and puckery to restrain, property is gentle, the Gorgon fruit mixture formed using Gorgon fruit as main ingredient With kidney tonifying, essence replenishing, strengthening the spleen and replenishing qi, respectful lung diuresis function has treatment chronic nephritis, all deficiency albuminuria of spleen kidney good Effect；
Chinese yam has higher nutritional ingredient, has the benefits of strengthening spleen and nourishing stomach, easy to digest.
Meanwhile except above-mentioned integration of drinking and medicinal herbs ingredient, Gallus domesticlus brisson and donkey-hide gelatin both integration of drinking and medicinal herbs ingredients can also be added, with It can be rapidly further that nephrosis dialysis patient supplements the nutrients comprehensively after mentioned component compatibility synergy, enhance immunocompetence, improve Body quality.
Gallus domesticlus brisson has 10 kinds of amino acid, protein, vitamin B2, niacin, vitamin E, phosphorus, iron, potassium, sodium content more Height, and cholesterol and fat content are then seldom, Chinese medicine think sweet Gallus domesticlus brisson smell, tepor, nontoxic, and edible Gallus domesticlus brisson is stopped with bowl spares Bitterly, nourishing liver and kidney, blood-enrich, regulating menstruation and activating blood, only collapses and controls band and other effects at nourishing Yin and clearing heat, especially to the deficiency of vital energy of women, blood Especially effective, the modern medicine study such as the diseases such as void, spleen deficiency, kidney deficiency and the slow, climacteric metancholia of women of children's upgrowth and development Think that Gallus domesticlus brisson contains the indispensable lysine of human body, methionine and histidine, immune function of human body and anti-aging can be adjusted；Its Be conducive to nephrosis dialysis patient rapidly to supplement the nutrients comprehensively, and can have with inflammation to alleviate by enhancing immune function of human body The malnutrition of pass promotes nephrosis to restore；
It is the severe complication of chronic kidney hypofunction that donkey-hide gelatin, which has powerful blood tonification effect, anaemia, and haemodialysis can improve The Water-Electrolyte of Chronic Renal Failure Patients, acid-base imbalance state remove uremic toxins, but cannot improve anaemia, and donkey-hide gelatin has aobvious Work improves red blood cell and hemoglobin, the effect for promoting hematopoiesis function, contributes to the generation for inhibiting anaemia, keeps nephrosis dialysis The stabilization of patient body quality.
The present invention is had the following technical effect that compared with prior art using above-mentioned technical proposal：
1) nephrosis of the invention dialysis tailored version clinical nutrition formula uses 18.6:24.1:57.3 protein：Fat： The energy supply ratio of carbohydrate provides balanced nutritional supplementation for patient.
2) protein source of the present invention is in lactalbumin, soybean protein isolate, whole milk powder, dried whole-egg, sea Foreign fish oligopeptide, oligopeptide refer to average molecular weight be 1000D or less, by bio-enzyme engineering technology from animal or vegetable protein The small molecule protein of middle separation and Extraction, have the characteristics that it is soluble easily in water, to acid, it is heat-staple, be not required to digest in human body It can directly absorb, bioavailability is high, and oligopeptide also has a series of physiology other than having corresponding trophic function Absorption and supplement, anti-sports fatigue, raising immunity, auxiliary adjustment blood pressure blood fat, antioxygen of the active function as promoted electrolyte Change, is antitumor, promoting the effects that bone growth.
3) 8-12 parts of fat of present invention addition, addition 4:1 ω -6 unsaturated fatty acids and omega-3 unsaturated fatty acid, energy Anti-inflammatory and vasoactive factors are enough generated, injury of kidney process is changed, reduce blood lipid level；Also add medium chain triglyceride, middle chain Triglycerides has the characteristics that energy supply is rapid, improves fat metabolism speed, will not inhibit immune system, nor affect on cholesterol generation It thanks, additionally it is possible to enhance absorption of the human body to calcium, magnesium and amino acid.
4) present invention addition prebiotics galactooligosaccharide, oligoisomaltose；Prebiotics can promote probiotics enteron aisle fixed It plants, enteron aisle convergence, reduce enteron aisle PH environment, the growth and breeding of human body beneficial bacteria is promoted to be helped to inhibit spoilage organisms to grow In improvement and maintain enteron aisle normal function；Long-term consumption can improve immunity, mitigate burden of liver, anti-aging, promote row Just.Oligoisomaltose is most excellent strain in prebiotics.
5) it is saturating can to prevent nephrosis using low-phosphorous, low potassium, the nephrosis dialysis tailored version clinical nutrition formula of low sodium by the present invention There are the clinical symptoms such as hyperphosphatemia and renal osteodystrophy in analysis patient.
6) present invention addition trace selenium, selenium can improve patient's glomerular filtration rate, mitigate the hair of nephrosis dialysis patient inflammation It is raw, there is protective effect, selenium can also improve the immunity of patient, the Hb values of patient be improved, to renal anemia the kidney of patient It makes moderate progress, preferably protects the renal function of patient, delay the progress of kidney trouble.
7) present invention addition Semen phaseoli radiati extract, Semen phaseoli radiati extract have extensive bacteriostatic activity, wherein n-butyl alcohol extract For the effective extract of bacteriostatic activity, there is different inhibition to make bacillus subtilis, staphylococcus albus, Escherichia coli, mould With the relevant malnutrition of inflammation can be effectively relieved, improve the body quality of patient.
8) tremella polysaccharides that the present invention adds can adjust the activity of glycometabolism enzyme, and islet secretion insulin is promoted to inhibit sugar Heteroplasia promotes utilization of the peripheral tissues to glucose, to have the function that hypoglycemic, raising immunity.
The present invention by select rational proportion basal nutrient element, while add with immunocompetence, improve renal anemia, Alleviate inflammation, the dietary fiber for enhancing human nutrition absorbability, diet essence, integration of drinking and medicinal herbs ingredient, natural plants compound And the special dietaries substance such as new resource food, and adjust its proportioning and carry out compatibility synergy, the present invention made with basal nutrient element Nephrosis dialysis tailored version clinical nutrition formula be easier to be absorbed by nephrosis dialysis patient, to give full play to the work(of each component It is underfed to solve nephrotic's simple malnutritive or Nosocomial of generally existing during haemodialysis for effect Situation improves body quality, accelerates the state of an illness and restores.
Specific implementation mode
The present invention provides a kind of nephrosis dialysis tailored version clinical nutrition formulas comprising following component and its parts by weight Number：15-25 parts of protein, 8-12 parts of fat, 50-54 parts of carbohydrate, 3-5 parts of dietary fibers, 0.3-0.6 parts of constant members Element, 0.01-0.05 parts of trace elements, 0.005-0.02 parts of liposoluble vitamins, 0.01-0.2 parts of water soluble vitamins, 0.05-1 Part diet essence, 0.05-2 parts of integration of drinking and medicinal herbs ingredients, 0.1-3 parts of natural plants compounds and 0.005-2 parts of new resource foods； Wherein, the fat includes medium chain triglyceride；Wherein, the dietary fiber selects water-soluble dietary fiber.
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention, But following embodiments are not intended to limit the scope of the invention.
Embodiment 1
Nephrosis dialysis tailored version clinical nutrition formula of the present invention includes PURE WHEY 12.8g, soybean separation protein White 6.8g, whole milk powder 4g, dried whole-egg 0.18g, colostrum 0.1g, taurine 0.12g, ocean fish oligopeptide 0.1g；Olive oil 1.82g, soybean oil 5.82g, coconut oil 1.1g, perilla herb oil 0.73g, medium chain triglyceride 0.24g；Maltodextrin 37.53g, wood Sweet potato starch 9.45g, cornstarch 5.46g；Water-soluble dietary fiber 4.55g in dietary fiber；Calcium 0.29g, phosphorus in macroelement 0.12g, potassium 0.02g, sodium 0.05g, magnesium 0.1g；Iron 0.011g, iodine 0.00014g, zinc 0.016g, selenium in trace element 0.00006g, copper 0.0004g, manganese 0.0001g；Vitamin A 0.0005g, beta carotene in liposoluble vitamin 0.000057g, vitamin D30.000001g, vitamin E 0.008g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.0002g, vitamin B120.000001g, vitamin C 0.102g, pantothenic acid 0.003g, leaf Sour 0.000023g, niacin 0.0133g；Mung bean flour 0.1g, white fungus powder 0.1g, broccoli powder 0.1g, salmon powder 0.1g, chicken 0.1g；Fermented Soybean 0.1g, Poria cocos 0.1g, raspberry 0.1g, matrimony vine 0.1g, sealwort 0.1g, campanulaceae 0.1g, Gorgon fruit 0.1g, Chinese yam 0.1g, l-cn 0.64g, avenabeta glucosan 0.02g.
Embodiment 2
Nephrosis dialysis tailored version clinical nutrition formula of the present invention includes PURE WHEY 12.8g, soybean separation protein White 6.8g, whole milk powder 4g, dried whole-egg 0.18g, colostrum 0.1g, taurine 0.12g, ocean fish oligopeptide 0.1g；Olive oil 1.82g, soybean oil 5.82g, coconut oil 1.1g, perilla herb oil 0.73g, medium chain triglyceride 0.24g；Maltodextrin 37.53g, wood Sweet potato starch 9.45g, cornstarch 5.46g；Water-soluble dietary fiber 4.55g in dietary fiber；Calcium 0.29g, phosphorus in macroelement 0.12g, potassium 0.02g, sodium 0.05g, magnesium 0.1g；Iron 0.011g, iodine 0.00014g, zinc 0.016g, selenium in trace element 0.00006g, copper 0.0004g, manganese 0.0001g；Vitamin A 0.0005g, beta carotene in liposoluble vitamin 0.000057g, vitamin D30.000001g, vitamin E 0.008g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.0002g, vitamin B120.000001g, vitamin C 0.102g, pantothenic acid 0.003g, leaf Sour 0.000023g, niacin 0.0133g；Mung bean flour 0.1g, white fungus powder 0.1g, broccoli powder 0.1g, salmon powder 0.1g, chicken 0.1g；Fermented Soybean 0.1g, Poria cocos 0.1g, raspberry 0.1g, matrimony vine 0.1g, sealwort 0.1g, campanulaceae 0.1g, Gorgon fruit 0.1g, Chinese yam 0.1g, Gallus domesticlus brisson 0.1g, donkey-hide gelatin 0.1g；L-cn 0.64g, avenabeta glucosan 0.02g.
Embodiment 3
Nephrosis dialysis tailored version clinical nutrition formula of the present invention includes PURE WHEY 5.8g, soybean protein isolate 13.8g, whole milk powder 4g, dried whole-egg 0.18g, colostrum 0.1g, taurine 0.12g, ocean fish oligopeptide 0.1g；Olive oil 1.82g, soybean oil 5.82g, coconut oil 1.1g, perilla herb oil 0.73g, medium chain triglyceride 0.24g；Maltodextrin 37.53g, wood Sweet potato starch 9.45g, cornstarch 5.46g；Water-soluble dietary fiber 4.55g in dietary fiber；Calcium 0.29g, phosphorus in macroelement 0.12g, potassium 0.02g, sodium 0.05g, magnesium 0.1g；Iron 0.011g, iodine 0.00014g, zinc 0.016g, selenium in trace element 0.00006g, copper 0.0004g, manganese 0.0001g；Vitamin A 0.0005g, beta carotene in liposoluble vitamin 0.000057g, vitamin D30.000001g, vitamin E 0.008g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.0002g, vitamin B120.000001g, vitamin C 0.102g, pantothenic acid 0.003g, leaf Sour 0.000023g, niacin 0.0133g；Mung bean flour 0.1g, white fungus powder 0.1g, broccoli powder 0.1g, salmon powder 0.1g, chicken 0.1g；Fermented Soybean 0.1g, Poria cocos 0.1g, raspberry 0.1g, matrimony vine 0.1g, sealwort 0.1g, campanulaceae 0.1g, Gorgon fruit 0.1g, Chinese yam 0.1g, l-cn 0.64g, avenabeta glucosan 0.02g.
Embodiment 4
Nephrosis dialysis tailored version clinical nutrition formula of the present invention includes PURE WHEY 12.8g, soybean separation protein White 6.8g, whole milk powder 4g, dried whole-egg 0.18g, colostrum 0.1g, taurine 0.12g, ocean fish oligopeptide 0.1g；Olive oil 1.82g, soybean oil 5.82g, coconut oil 1.1g, perilla herb oil 0.73g, medium chain triglyceride 0.24g；Maltodextrin 37.53g, wood Sweet potato starch 9.45g, cornstarch 5.46g；Water-soluble dietary fiber 4.55g in dietary fiber；Calcium 0.29g, phosphorus in macroelement 0.12g, potassium 0.02g, sodium 0.05g, magnesium 0.1g；Iron 0.011g, iodine 0.00014g, zinc 0.016g, selenium in trace element 0.00006g, copper 0.0004g, manganese 0.0001g；Vitamin A 0.0005g, beta carotene in liposoluble vitamin 0.000057g, vitamin D30.000001g, vitamin E 0.008g；Vitamin B in water soluble vitamin10.001g, dimension life Plain B20.001g, vitamin B60.0002g, vitamin B120.000001g, vitamin C 0.102g, pantothenic acid 0.003g, leaf Sour 0.000023g, niacin 0.0133g；Mung bean flour 0.01g, white fungus powder 0.01g, broccoli powder 0.01g, salmon powder 0.01g, Chicken 0.01g；Fermented Soybean 0.01g, Poria cocos 0.01g, raspberry 0.01g, matrimony vine 0.01g, sealwort 0.01g, campanulaceae 0.01g, Gorgon euryale Real 0.01g, Chinese yam 0.01g, l-cn 0.64g, avenabeta glucosan 0.02g.
Embodiment 5
A kind of preparation method of nephrosis dialysis tailored version clinical nutrition formula as described in 1~embodiment of embodiment 4 is as follows：
1) powdered oil (powder fat) is prepared：
A) wall material aqueous solution is prepared：Take maltodextrin 8g, soybean protein isolate 4g, whole-fat milk powder 11g, dietary fiber 2g (resistant dextrin), inulin 1.5g, PURE WHEY 5g, oligoisomaltose 0.5g, Arabic gum 0.2g, cornstarch 0.5g, Tapioca powder 2g, water 50mL are stirred evenly and (are had ready conditions and heat while stirring to 60 DEG C, keep 30 minutes postcoolings to room temperature).
B) by monoglyceride take 0.1g (a concentration of 0.2%) of total solid be uniformly dissolved in 10.8mL greases (olive oil 2mL, Soybean oil 6.5mL, coconut oil 1.2mL, perilla herb oil 0.8mL, medium chain triglyceride 0.3mL).
C) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in wall material aqueous solution.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1g (a concentration of 0.2%) of total solid is settled into after mixed solution with water 200mL (a concentration of 25%) of total solid, high speed dispersion 2 minutes under 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).
G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, be added weight be raw material weight 3~8 times of water, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved with 60~80 mesh Prepare integration of drinking and medicinal herbs component powders；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core material, select carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material It is instantaneous dry, prepare liposoluble vitamin powder with 60~80 mesh screenings；Using the water soluble vitamin of predetermined weight number as Core material is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, and sprays instantaneous dry, is prepared with the screening of 60~80 mesh water-soluble Property vitamin powder；
4) by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, micro Element, diet essence, natural plants compound and new resource food prepare the powder that granulating grain size is 150~250 μm respectively；
5) mixing machine that the powder obtained by step 1)~step 4) is sequentially added to cone-type mixer or other forms is mixed Uniformly obtained formula mixture is closed, it is spare after sterilization processing；
6) according to conventional technical means by the formula mixture in step 5) be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral solution.
In step 6), optionally increase suitable food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, food flavor fragrance, brown sugar；More preferable carragheen, Arabic gum, Guar Glue, Aspartame, food flavor fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 6
The present embodiment is verification embodiment.
This verification embodiment verifies nephrosis of the present invention and dialyses tailored version clinical nutrition formula to nephrosis dialysis patient Influence.Electuary and following comparative example of the present embodiment using the formula preparation of Examples 1 and 2：
Control group：Person in middle and old age's Nutrious milk powder (Erie)；
Experimental group 1：The electuary prepared using the nutrient formulation of embodiment 1；
Experimental group 2：The electuary prepared using the nutrient formulation of embodiment 2；
Experimental group 3：The electuary prepared using dietary fiber is deleted in the nutrient formulation of embodiment 1；
Experimental group 4：The electuary prepared using integration of drinking and medicinal herbs ingredient is deleted in the nutrient formulation of embodiment 1；
The gerontal patient 30 of the nephrosis dialysis of corresponding electuary is voluntarily taken in every group of selection above, and each group patient carries out often Rule nursing.According to the normal nutrition intake of patient, the electuary of the present invention is given in the time of normally ingesting, 4 times a day, original dialysis Number and medicine type and quantity are constant.Experimental result statistics is carried out after 2 months, experimental result is average value, experiment The results are shown in table below：
The variation of the edible front and back nephrosis dialysis patient clinical indices of table one
As seen from the above table, nephrosis of the invention dialysis tailored version clinical nutrition formula can be effectively improved the battalion of nephrosis dialysis The state of supporting, contributes to patient to restore.The effect of embodiment 2 is better than other experimental groups.
By above-described embodiment it is found that each component cooperates in the nephrosis dialysis tailored version clinical nutrition formula of the present invention, Reasonable, comprehensive, balanced nutritional support is provided for nephrosis dialysis patient, to improve the physical condition of nephrosis dialysis patient, keep The stabilization of patient body quality, booster immunization responsibility, at the same add dietary fiber, diet essence, integration of drinking and medicinal herbs ingredient, Natural plants compound and new resource food etc., which have, to be improved immunocompetence, repairs renal function, the state that reduces inflammation, inhibits Kidney damage improves oxygen radical removing ability and inner skin cell function, contributes to the absorption of nephrosis dialysis patient and Replacement Battalion It supports, reduces nephrosis dialysis patient case fatality rate and complication rate, advantageously reduce the underfed occurrence risk of patient, promoted The prognostic level of patient is conducive to the recovery of nephrosis dialysis patient.
Specific embodiments of the present invention are described in detail above, but it is intended only as example, the present invention is simultaneously unlimited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and It substitutes also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by impartial conversion and Modification, all should be contained within the scope of the invention.

Claims (10)

  1. The tailored version clinical nutrition formula 1. a kind of nephrosis is dialysed, which is characterized in that including following component and its parts by weight：15- 25 parts of protein, 8-12 parts of fat, 50-54 parts of carbohydrate, 3-5 parts of dietary fibers, 0.3-0.6 parts of macroelements, 0.01- 0.05 part of trace element, 0.005-0.02 parts of liposoluble vitamins, 0.01-0.2 parts of water soluble vitamins, 0.05-1 parts of diet essences China, 0.05-2 parts of integration of drinking and medicinal herbs ingredients, 0.1-3 parts of natural plants compounds and 0.005-2 parts of new resource foods；
    Wherein, in the nutrient formulation, protein：Fat：The productivity ratio of carbohydrate is 15~20：20~25：50~60.
    Wherein, the integration of drinking and medicinal herbs ingredient includes Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, campanulaceae, Gorgon fruit, Chinese yam, mountain At least one of short, bristly hair or beard, Gallus domesticlus brisson, donkey-hide gelatin.
  2. The tailored version clinical nutrition formula 2. a kind of nephrosis according to claim 1 is dialysed, which is characterized in that the protein Including in lactalbumin, soybean protein isolate, whole milk powder, dried whole-egg, ocean fish oligopeptide, colostrum, taurine at least It is a kind of.
  3. The tailored version clinical nutrition formula 3. a kind of nephrosis according to claim 1 is dialysed, which is characterized in that the fat packet Include medium chain triglyceride, olive oil, soybean oil, coconut oil, perilla herb oil.
  4. The tailored version clinical nutrition formula 4. a kind of nephrosis according to claim 1 is dialysed, which is characterized in that the diet is fine Dimension include inulin, konjaku flour, galactooligosaccharide, oligofructose, oligoisomaltose, soybean polyoses, cyclodextrin, resistant dextrin, At least one of soybean fiber.
  5. The tailored version clinical nutrition formula 5. a kind of nephrosis according to claim 1 is dialysed, which is characterized in that the diet is fine Dimension selects water-soluble dietary fiber.
  6. The tailored version clinical nutrition formula 6. a kind of nephrosis according to claim 1 is dialysed, which is characterized in that the micro member The parts by weight of selenium are 0.00001~0.0001 part in element.
  7. The tailored version clinical nutrition formula 7. a kind of nephrosis according to claim 1 is dialysed, which is characterized in that the diet essence China include cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fish and shrimp, poultry meat, in fruits at least It is a kind of；
    Wherein, the cereal includes rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn flour, wheat germ powder, oatmeal, buckwheat At least one of flour, the beans include at least one of peameal, mung bean flour, black bean powder, red bean powder, soy meal, The potato is mainly made of common yam rhizome powder, the greengrocery include carrot meal, white radish powder, pumpkin powder, spinach powder, tomato meal, At least one of broccoli powder, balsam pear powder, the Homonemeae include at least one of mushroom powder, Kelp Powder and white fungus powder, The nut-seed class includes at least one of pumpkin seed powder and lotus nut starch, and the fish and shrimp include salmon powder and cod meal At least one of, the poultry meat includes at least one of chicken meal, powdered beef and pig kidney powder, and the fruits include At least one of red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder.
  8. 8. the preparation method of the nephrosis dialysis tailored version clinical nutrition formula according to any one of claim 1-7, special Sign is, includes the following steps：
    Step 1, powder fat is prepared；
    Step 2, integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, be added weight be raw material weight 3~8 times of water, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, sieved with 60~80 mesh Prepare integration of drinking and medicinal herbs component powders；
    Step 3, liposoluble vitamin powder and water soluble vitamin powder are prepared：By the liposoluble vitamin of predetermined weight number It as core material, selects carragheen, Arabic gum as wall material, carries out 2 emulsifying homogeneous processing, emulsifying homogeneous time under high pressure For 10~15min, instantaneous drying of spraying then is carried out, liposoluble vitamin powder is prepared with 60~80 mesh screenings；By predetermined weight The water soluble vitamin of number is measured as core material, selects maltodextrin, lipoprotein as wall material, is uniformly mixed, spray instantaneous dry It is dry, prepare water soluble vitamin powder with 60~80 mesh screenings；
    Step 4, by the protein of predetermined weight and amino acid, nucleotide, carbohydrate, dietary fiber, macroelement, micro Element, diet essence, natural plants compound and new resource food are prepared into the powder that grain size is 150~250 μm respectively；
    Step 5, the powder obtained by step 1~4 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, by sterilization It is spare after processing；
    Step 6, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution It is at least one；
    Wherein, the sequence of step 1~4 can be replaced mutually.
  9. 9. preparation method according to claim 8, which is characterized in that prepare powder fat in the step 1 and specifically include Following steps：
    1) wall material aqueous solution is prepared：Take maltodextrin 8g, soybean protein isolate 4g, whole-fat milk powder 11g, dietary fiber 2g, inulin 1.5g, PURE WHEY 5g, oligoisomaltose 0.5g, Arabic gum 0.2g, cornstarch 0.5g, tapioca 2g, water 50mL is stirred evenly；
    2) monoglyceride is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in 10.8mL mixed plant greases；It is described mixed Vegetable fat is closed by 2mL olive oil, 6.5mL soybean oils, 1.2mL coconut oil, 0.8mL perilla herb oils, 0.3mL medium chain triglyceride groups At；
    3) Tween 80 is taken into 0.1g (a concentration of 0.2%) of total solid is uniformly dissolved in the wall material aqueous solution；
    4) the mixed plant grease and the wall material aqueous solution of addition Over emulsfication agent Tween 80 that add Over emulsfication agent monoglyceride is abundant Mixing, obtains mixed solution；
    5) (a concentration of 0.2%) of total solid is settled to 200mL to addition stabilizer agar 0.1g after the mixed solution with water (a concentration of 25%) of total solid, high speed dispersion 2 minutes, obtains emulsion under 20000r/min；
    6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times 5 minutes every time, obtains homogeneous emulsion；
    7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, and collection obtains powder Last fat.
  10. 10. preparation method according to claim 8, which is characterized in that the step 6 is added with food and thickens in the preparation Agent and food additives；
    Wherein, the food thickening agent include guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, At least one of Arabic gum, the food additives include at least one in Aspartame, food flavor fragrance, brown sugar Kind.
CN201810444527.1A 2018-05-10 2018-05-10 Nephrosis dialysis tailored version clinical nutrition formula and preparation method thereof Pending CN108651988A (en)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109497514A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 AIDS tailored version clinical nutrition formula and preparation method thereof
CN109497520A (en) * 2018-11-15 2019-03-22 上海奥医生物医药科技有限公司 A kind of self-closing disease tailored version clinical nutrition composition and preparation method thereof
CN109497563A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 Leucoderma tailored version clinical nutrition formula and preparation method thereof
CN110200273A (en) * 2019-06-06 2019-09-06 王仲 A kind of clinical liver disease nutritious food and preparation method thereof
CN110226743A (en) * 2019-07-05 2019-09-13 济南大学 A kind of Adult chronic's kidney trouble nontransparent PCI-PCI bridge wholefood formula and preparation method thereof
CN110463989A (en) * 2019-07-24 2019-11-19 浙江禾健生营养科技有限公司 A kind of full nutrient formulation powder of nephrosis tailored version and preparation method thereof
CN112120222A (en) * 2020-10-08 2020-12-25 菏泽嘉麟生物科技有限公司 Method for preparing bioengineering fermented selenium product
CN114868911A (en) * 2022-05-19 2022-08-09 陕西巨子生物技术有限公司 Medical nutrition powder for kidney disease non-dialysis patients and preparation method thereof
CN115054677A (en) * 2022-03-24 2022-09-16 大医声科技(北京)有限公司 Multi-vitamin nutrient formula suitable for patients with nephropathy
CN115137059A (en) * 2022-05-23 2022-10-04 青岛普瑞森医药科技有限公司 Non-full-nutrition food for improving nephropathy and preparation process thereof
CN115226825A (en) * 2022-06-21 2022-10-25 肖玉顺 Functional solid beverage

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106858620A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106942748A (en) * 2017-03-29 2017-07-14 上海奥医生物医药科技有限公司 A kind of female acyesis tailored version clinical nutrition formula and preparation method thereof
CN106962912A (en) * 2017-03-29 2017-07-21 上海奥医生物医药科技有限公司 A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN106983151A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN106983136A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof
CN107319524A (en) * 2017-06-29 2017-11-07 上海复旦奥医医学科技有限公司 A kind of nephrosis tailored version clinical nutrition formula and preparation method thereof
CN107440103A (en) * 2017-08-23 2017-12-08 上海奥医生物医药科技有限公司 A kind of respiratory disease tailored version clinical nutrition formula and preparation method thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106858620A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106942748A (en) * 2017-03-29 2017-07-14 上海奥医生物医药科技有限公司 A kind of female acyesis tailored version clinical nutrition formula and preparation method thereof
CN106962912A (en) * 2017-03-29 2017-07-21 上海奥医生物医药科技有限公司 A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN106983151A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN106983136A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof
CN107319524A (en) * 2017-06-29 2017-11-07 上海复旦奥医医学科技有限公司 A kind of nephrosis tailored version clinical nutrition formula and preparation method thereof
CN107440103A (en) * 2017-08-23 2017-12-08 上海奥医生物医药科技有限公司 A kind of respiratory disease tailored version clinical nutrition formula and preparation method thereof

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109497514A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 AIDS tailored version clinical nutrition formula and preparation method thereof
CN109497563A (en) * 2018-10-23 2019-03-22 上海奥医生物医药科技有限公司 Leucoderma tailored version clinical nutrition formula and preparation method thereof
CN109497520A (en) * 2018-11-15 2019-03-22 上海奥医生物医药科技有限公司 A kind of self-closing disease tailored version clinical nutrition composition and preparation method thereof
CN110200273A (en) * 2019-06-06 2019-09-06 王仲 A kind of clinical liver disease nutritious food and preparation method thereof
CN110226743A (en) * 2019-07-05 2019-09-13 济南大学 A kind of Adult chronic's kidney trouble nontransparent PCI-PCI bridge wholefood formula and preparation method thereof
CN110463989A (en) * 2019-07-24 2019-11-19 浙江禾健生营养科技有限公司 A kind of full nutrient formulation powder of nephrosis tailored version and preparation method thereof
CN112120222A (en) * 2020-10-08 2020-12-25 菏泽嘉麟生物科技有限公司 Method for preparing bioengineering fermented selenium product
CN115054677A (en) * 2022-03-24 2022-09-16 大医声科技(北京)有限公司 Multi-vitamin nutrient formula suitable for patients with nephropathy
CN114868911A (en) * 2022-05-19 2022-08-09 陕西巨子生物技术有限公司 Medical nutrition powder for kidney disease non-dialysis patients and preparation method thereof
CN115137059A (en) * 2022-05-23 2022-10-04 青岛普瑞森医药科技有限公司 Non-full-nutrition food for improving nephropathy and preparation process thereof
CN115226825A (en) * 2022-06-21 2022-10-25 肖玉顺 Functional solid beverage

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