CN106962912A

CN106962912A - A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof

Info

Publication number: CN106962912A
Application number: CN201710198915.1A
Authority: CN
Inventors: 尤俊; 季敬东
Original assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Current assignee: Shanghai Olympic Medical Biotechnology Co Ltd
Priority date: 2017-03-29
Filing date: 2017-03-29
Publication date: 2017-07-21

Abstract

The present invention relates to a kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof, including protein, fat, carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resource food；Wherein, new resource food includes swan-mussel polysaccharide, and integration of drinking and medicinal herbs composition includes peppermint, Poria cocos, matrimony vine, pawpaw, Chinese yam, mulberries, spina date seed, citron；Its preparation method is：Each component is previously prepared into powder, is then well mixed and corresponding formulation is made；Wherein, integration of drinking and medicinal herbs composition carries out water extraction concentration, spray drying and powder is made, and vitamin and fat are handled by microencapsulation respectively is made powder.Screening and proportioning by said components; nutrient formulation of the present invention can be energy, critical nutrients and the essential trace element needed for hepatopath provides; under the synergy of each component, the treatment of hepatopathy and the protection of liver cell are carried out, slows down the disease development of hepatopathy.

Description

A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof

Technical field

The present invention relates to enteral nutrition preparation field, and in particular to a kind of hepatopathy tailored version clinical nutrition formula and its preparation Method.

Background technology

Hepatopathy refers to the lesion for occurring in liver, is a kind of great disease of common harmfulness.Hepatopathy species is according to hair Anttdisease Mechanism can be divided into viral liver disease and Non-viral liver disease.Viral liver disease is one as caused by a variety of different hepatitis viruses Group with liver do harm to based on infectious disease, according to etiological diagnosis, hepatitis viruse at least 5 kinds, i.e. first, second, third, fourth, penta type liver Scorching virus, causes first, second, third, fourth, viral hepatitis type E respectively；Non-viral liver disease includes following several：AML It is due to the hepar damnification disease caused by long-term heavy drinking (being addicted to drink)；Medicine or poisonous substance hepatopathy be by chemical toxicant (such as Phosphorus, arsenic, carbon tetrachloride etc.), medicine or hepatitis or caused hepatic disease caused by biotoxin；Pathobolism liver Disease is in vivo to the bad caused hepatopathy of certain material metabolism；Fatty liver disease refers to due to liver caused by a variety of causes The excessive lesion of intracellular fat accumulation, causing the fat content of liver cell increases, and possible cause has excessive drinking, diabetes, blood fat Fat is too high, overweight etc..

Liver is the maximum metabolic organ of human body, while being also one of most important internal organs in digestive system, it joins extensively With internal complicated biochemical process, including carbohydrate, metabolism, the storage of vitamin and the activation of fat and protein etc., Removing toxic substances and generation metabolic waste etc..Liver will appear from complexity nutrient metabolic when ill changes, especially in End-stage liver disease or In patient's body of liver failure, liver function, which is badly damaged, greatly affected body substance and energetic supersession, thus generally Cause more serious malnutrition.Therefore, to liver diseases or dyshepatia patient, it should be changed according to disease event, metabolism And nutrition condition, suitable energy substance and nutritional supportive path are selected, rational nutritional support is carried out.

With the development of food of special nutrients, according to the physilogical characteristics and nutritional need of hepatopath, for hepatopath The special formulation food of exploitation is also increasing, and such as Chinese patent CN105942506A discloses a kind of suitable for hepatopath's Special medicine purposes formula food, but it is not added with dietary fiber, meals elite, integration of drinking and medicinal herbs composition and new resource food, this Cause it can not fully meet the nutritional need of hepatopath, it is alleviated and the effect for the treatment of hepatopathy is extremely limited；It is Chinese special Sharp CN105361146A discloses the full nutrition special formulation food that a kind of hepatopath eats, but its medicine-food two-purpose for being used Up to 31 kinds of Chinese herbal medicine extract, and it not using compositions such as meals elite, and the processing of each composition is relative complex, this causes Its product cost is higher.

Therefore, be badly in need of that a kind of component is less but nutritional ingredient comprehensively and the price more cheap spy suitable for hepatopath Different formula food.

The content of the invention

It is an object of the invention to overcoming defect of the prior art to be formulated there is provided a kind of hepatopathy tailored version clinical nutrition and Its preparation method, hepatopathy tailored version clinical nutrition formula prepared by the present invention provides comprehensive nutritional support for hepatopath, its Containing the suitable energy and various critical nutrients needed for hepatopath, there is provided complete required micro-nutrient composition；Pass through Integration of drinking and medicinal herbs composition and new resource food of the addition containing a variety of functional active components, it can mitigate liver kidney burden, be effective against Inflammation, killing virus, strengthens resistance of human body, also with clearing heat and detoxicating, regulating the function of the liver and spleen and prevents and treats the functions such as hepatopathy, nutrition Each composition complements each other in formula, can effectively improve the malnutritive symptom of hepatopath, and conditioning engine body function, is conducive to liver The anti-inflammatory liver protection of patient, and improve the life quality of patient and slow down disease development.

To achieve the above object, the present invention is adopted the following technical scheme that：

On the one hand, the present invention provides a kind of hepatopathy tailored version clinical nutrition formula, including following component：Protein, fat, Carbohydrate, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants Compound and new resource food；Wherein, the new resource food includes swan-mussel polysaccharide；Wherein, the integration of drinking and medicinal herbs composition includes Peppermint, Poria cocos, matrimony vine, pawpaw, Chinese yam, mulberries, spina date seed, citron.

In order to further optimize above-mentioned technical proposal, the technical measures that the present invention is taken also include：

Preferably, the hepatopathy tailored version clinical nutrition formula, in addition to food thickening agent and food additives, the food Product thickener be guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum at least One kind, the food additives are at least one of Aspartame, flavoring essence spices, brown sugar.

Preferably, the vitamin is water soluble vitamin and liposoluble vitamin, the weight of the liposoluble vitamin Account for the 10%~40% of vitamin gross weight.

Preferably, the dietary fiber is water-soluble dietary fiber and insoluble dietary fiber, wherein the water-soluble meals The weight of food fiber accounts for the 70%~75% of dietary fiber gross weight；

Preferably, the parts by weight of the component are：20~30 parts of protein, 5~15 parts of fat, carbohydrate 45~ 55 parts, 2~8 parts of dietary fiber, 0.6~1.2 part of macroelement, 0.01-0.06 parts of trace element, vitamin 0.05~0.25 Part, 0.5~1.5 part of meals elite, 0.1~6 part of integration of drinking and medicinal herbs composition, 0.1-1 parts of natural plants compound and new resources food 0.01-0.1 parts of product.

Preferably, the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：0~1 part of peppermint, 0~1 part of Poria cocos, 0~1 part of matrimony vine, 0~1 part of pawpaw, 0~1 part of Chinese yam, 0~1 part of mulberries, 0~1 part of spina date seed, 0~1 part of citron.

Preferably, the protein is selected from PURE WHEY, soybean protein isolate, whole milk powder, dried whole-egg, newborn iron egg In vain, at least one of bovine colostrum, amino acid, protein peptides；Wherein, the amino acid is selected from 1B-Pidolidone, L- In glutamic acid, L-arginine, L-Trp, Glu, taurine, Valine, ILE, L-Leu extremely Few one kind；The protein peptides be selected from soybean oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, At least one of amino peptide, ovalbumin peptide.

Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically it is described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm oil, butter, Cream, lard, medium chain triglyceride, lecithin, single diglycerine fatty acid ester.

Preferably, the carbohydrate is included in fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least two.

Preferably, the dietary fiber comprising inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one of soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber.

Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate At least one of with magnesium gluconate.

Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.

Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D₃, vitamin E, vitamin K₁ At least one of.

Preferably, the water soluble vitamin is selected from vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, vitamin At least one of C, pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.

Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；Wherein described cereal it is main by rice meal, millet powder, black rice flour, coixlacrymajobi powder, One kind in corn flour, wheat germ powder, oatmeal, buckwheat or at least two compositions, the beans it is main by peameal, it is green One kind or at least two compositions in bean powder, black bean powder, red bean powder, soy meal, the potato class is mainly made up of common yam rhizome powder, described Vegetable powder is main by one in carrot meal, white radish powder, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder, cucumber powder Plant or several compositions, the Homonemeae is main by the one or more in mushroom powder and white fungus powder, and the nut-seed class is main It is lotus nut starch, the fish and shrimp are mainly made up of the one or more in salmon powder and cod meal, the poultry meat master If being made up of the one or more in chicken meal, powdered beef, the fruits are main by red date powder, longan powder, apple powder, cherry One or more of compositions in peach powder, citrus powder, pyrus nivalis powder；It is the preferred coixlacrymajobi powder of meals elite, oatmeal, buckwheat, red Bean powder, carrot meal, broccoli powder, white fungus powder, salmon powder, powdered beef, red date powder.

Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one of sterol, lycopene, resveratrol, allicin；The natural plants compound is preferably l-cn.

Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, freshwater mussel In meat polysaccharide, bamboo-leaves flavones, CPP, avenabeta glucosan, yeast beta-dextran, leaf of Moringa, xylo-oligosaccharide extremely Few one kind；The new resource food is preferably swan-mussel polysaccharide.

On the other hand, the present invention relates to a kind of preparation method of above-mentioned hepatopathy tailored version clinical nutrition formula, including it is as follows Step：

Step 1: by the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, micro It is 150~250 that element, vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food are prepared into particle diameter respectively μm powder；

It is well mixed Step 2: powder prepared by the step one is poured into cone-type mixer successively；

Step 3: using the step one be well mixed powder be prepared into nutrient powder, nutrition emulsion, capsule, tablet, At least one of pill or oral liquid；

Wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, water extraction is concentrated, and concentrate is carried out into spray drying system Into integration of drinking and medicinal herbs component powders；

Wherein, the vitamin and fat are handled by microencapsulation respectively is prepared into vitamin powder and fat powder.

Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, is added 3~8 times of the water that weight is raw material weight, is carried out immersion 3 ~4 hours, then soak is carried out to decoct 30~60min, filtering removes raw material, leaves and takes decoction liquor, spray decoction liquor Mist drying prepares integration of drinking and medicinal herbs component powders.

Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) it regard liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer are as wall material, high-pressure homogeneous emulsification, and spraying is instantaneous to be dried, and screening prepares liposoluble Property vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, whey egg One or more in white powder, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer are mixed as wall material Close uniform, spraying is instantaneous to be dried, and screening prepares water soluble vitamin powder.

Preferably, the specific implementation step of the fatty micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall material with Water mixed dissolution prepares emulsion；After the stirring mixing of above-mentioned emulsion, emulsifying homogeneous processing is carried out, spraying is then carried out dry Dry, screening prepares powdered oil, and powdered oil is compared with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), One or more in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin；The wall Material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer.

The present invention using have anti-inflammatory protect liver, the integration of drinking and medicinal herbs composition of strengthen immunity, it include peppermint, Poria cocos, matrimony vine, Pawpaw, Chinese yam, mulberries, spina date seed, citron.

Mint extract sample has significant protective effect to D-Gal induced mice acute liver damage, and peppermint carries Take thing sample to dramatically increase rat bile secretory volume, there is obvious choleretic effect to rat.

Poria cocos can strengthen body's immunity, and pachymaran has obvious antitumor action；There is diuresis, urine can be increased The discharge of the electrolyte such as middle potassium, sodium, chlorine；There are the effects such as calm and protection liver, the generation, the hypoglycemic, anti-radiation that suppress ulcer.

LBP-X has repair to hepatic injury caused by carbon tetrachloride in matrimony vine, and its mechanism may be by prevention The damage of matter net, promotes protein synthesis and detoxication, recovers the function of liver cell, and promote liver cell regeneration；Matrimony vine is thick Polysaccharide can reduce hepatic tissue mda content, and carbon tetrachloride hepatic injury mouse liver glycogen content can be made significantly to raise, and improve human body Energy reserve；The active ingredient in matrimony vine can improve mitochondrial form to alcoholic liver disease of rats model, mitigate liver simultaneously The steatosis and inflammation degree of necrosis of cell.

Contain multiple beneficial composition, including pawpaw polysaccharide, papain, oleanolic acid, phytosterin compound in pawpaw Deng；Pawpaw polysaccharide has anticoagulation, suppression infection, imperial radiation, antitumor, anti-inflammatory, antiviral, the anti-ageing effect of waiting for a long time, and is preferable Immunopotentiator；Papain can decomposing protein, have auxiliary treatment enterogastritis, indigestion, pawpaw contains a variety of water Soluble vitamin, is such as rich in vitamin C, helps to repair body tissue, eliminates the noxious material of infringement body cell, strengthens people Body resistance against diseases；Oleanolic acid exists with monomer or saponin form, internal with anti-inflammatory, strengthen immunity, transaminase lowering, correction Paraprotein is metabolized, prevents hepatic sclerosis；Phytosterin compound, has stronger antiinflammatory action to human body, can promote wound healing, Make hypertrophy, enhancing capillary circulation.

Chinese yam especially Chinese yam polysaccharide has good immunoregulation effect, and the phosphatide constituents of Chinese yam, which have, improves immune The effect of function, Chinese yam is that Chinese medicine is adjusted in tonifying middle-Jiao and Qi, has good adjustment effect to digestion function, Chinese yam can also increase Strong Small Intestinal, suppressing the allantoin in the secretion of serum amylase, Chinese yam has anti-irritant, analgesia, anti-inflammatory suppression Bacterium etc. acts on.

Active ingredient mulberry polysaccharide in mulberries can be remarkably decreased the Th2 cytohormones secreted by spleen cell, blood processed Clear IgG1 generation, reduces the secretion of abdominal cavity cell TNF-α, and the effect with anti-inflammatory slows down allergic immune response.

Spina date seed aqueous extract has obvious antiinflammatory action, can suppress mouse peritoneal, skin of back and auricle blood capillary Pipe permeability, has inhibitory action to the granuloma that the swelling of rat hindleg egg white and the rat oxter implantation scraps of paper are produced, has Effect of strengthen immunity.

Volatile oil contained by citron has gentle stimulation to intestines and stomach, can promote to wriggle and digestive juice secretion in stomach, row Except enteral pneumatosis, and there are phlegm-dispelling functions；Hesperidine contained by fragrant pavilion has anti-inflammatory, an antivirus action, and with prevention frostbite and Suppress the aldehyde reductase effect of rat lens；Obakunone contained by fragrant pavilion plays the role of enhancing isolated rabbit intestines tension force and amplitude.

The present invention also uses new resource food, including swan-mussel polysaccharide, and swan-mussel polysaccharide can improve hepatocyte viability and peroxide Compound is disproportionated enzyme activity, and it has direct protective action to liver cell, and it can significantly increase index and spleen index, thymus index Deng with certain vivo immunization humidification.

The present invention also uses meals elite, including coixlacrymajobi powder, oatmeal, buckwheat, red bean powder, carrot meal, broccoli Powder, white fungus powder, salmon powder, powdered beef, red date powder, its comprehensive nutrition are more beneficial for the physical recovery and stomach of hepatopath Conditioning.

Compared with prior art, the present invention has following excellent effect：

(1) modern nutriology achievement in research is combined by the present invention with Traditional Chinese medical theory, passes through the organic of various components Combination, various functions is merged, and pass through the synergy between active ingredient, humidification effect.Match somebody with somebody by the present invention The food that side makes can not only supplement nutrition needed for hepatopath, moreover it is possible to promote body condition to improve using medicinal herb componentses.

(2) inventive formulation food is using the peppermint in integration of drinking and medicinal herbs composition, Poria cocos, matrimony vine, pawpaw, Chinese yam, mulberries, acid Jujube kernel, citron, it, which has, improves the effects such as immunity, anti-inflammatory protect liver, antiviral, dampness removing invigorating the spleen；It is easy using amino acid and polypeptide In absorption, immunity of organisms can be improved；Using natural plants compound l-cn, to supplement because carnitine is sought caused by hepatopathy Support and lack, maintain the normal function of body；Using new resource food swan-mussel polysaccharide, liver cell is further protected；In said components Synergy under, can be comprehensively quickly nutrient necessary to hepatopath, while the treatment of positive carry out hepatopathy And the protection of liver cell, improve the life quality of patient and slow down disease progression.

(3) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, it is easy to be well mixed with other powdered components；And use micro-capsule bag Bury after technology, grease is embedded in wall material, so that the contact with air is avoided to strengthen inoxidizability, so as to play guarantor The maximum effect of strong type grease.

(4) raw material of hepatopathy tailored version clinical nutrition of the present invention formula in preparation process it is previously prepared into 150~250 μm of powder, this make it that, when preparing finished product, each nutrition composition can be well mixed, it is ensured that each in unit volume The content of nutrition composition is identical, while when preparing liquid type preparation, each nutrition composition can be fully dispersed and is completely dissolved to molten In agent, prevent occurring solid precipitation in liquid, effect of finished product product has been effectively ensured.

Embodiment

The present invention provides a kind of for hepatopathy tailored version clinical nutrition formula tailored version clinical nutrition formula, including following weight Measure the component of number：20~30 parts of protein, fat 5~15 parts, 45~55 parts of carbohydrate, 2~8 parts of dietary fiber, often 0.6~1.2 part of secondary element, 0.01-0.06 parts of trace element, 0.05~0.25 part of vitamin, 0.5~1.5 part of meals elite, medicine Food is with 0.01-0.1 parts of 0.1~6 part of derived components, 0.1-1 parts of natural plants compound and new resource food；Wherein, the dimension Raw element is water soluble vitamin and liposoluble vitamin, the weight of the liposoluble vitamin account for vitamin gross weight 10%~ 40%；Wherein, the dietary fiber is water-soluble dietary fiber and insoluble dietary fiber, wherein the water-soluble dietary fiber Weight account for the 70%~75% of dietary fiber gross weight.

With reference to embodiment, the embodiment to the present invention is further described.Following examples are only used for more Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.

Embodiment 1

Hepatopathy tailored version clinical nutrition formula of the present invention includes PURE WHEY 14.64g, soybean protein isolate 8.18g, whole milk powder 10g, dried whole-egg 0.18g, bovine colostrum 0.1g, taurine 0.12g, soy oligosaccharides Gly-His-Lys 0.1g, ocean Fish oligopeptide powder 0.1g；Olive oil 0.39g, soybean oil 0.63g, coconut oil 0.39g, perilla herb oil 0.27g, medium chain triglyceride 3.03g, single diglycerine fatty acid ester 0.09g；Maltodextrin 33.4g, tapioca 11.63g；Resistant dextrin 2.7g, oligomeric half Lactose 0.54g, inulin 0.9g, oligoisomaltose 0.91g；Calcium 0.15g, phosphorus 0.256g, potassium 0.093g, sodium in macroelement 0.177g, magnesium 0.177g；Iron 0.011g, zinc 0.007g in trace element；Vitamin A 0.004g, beta carotene 0.017g, dimension Raw element D₃0.0005g, vitamin E 0.009g；Vitamin B₁0.001g, vitamin B₂0.001g, vitamin B₆ 0.001g、 Vitamin B₁₂0.00013g, vitamin C 0.127g, pantothenic acid 0.003g, folic acid 0.00017g, nicotinic acid 0.0133g；Coixlacrymajobi powder 0.09g, oatmeal 0.09g, buckwheat 0.09g, red bean powder 0.09g, carrot meal 0.09g, broccoli powder 0.09g, white fungus powder 0.09g, salmon powder 0.09g, powdered beef 0.09g, red date powder 0.09g；Peppermint 0.05g, Poria cocos 0.05g, matrimony vine 0.05g, wood Melon 0.05g, Chinese yam 0.05g, mulberries 0.05g, spina date seed 0.05g, citron 0.03g；L-cn in natural plants compound 0.5g；Swan-mussel polysaccharide 0.01g in new resource food；Wherein, the weight of the water-soluble dietary fiber accounts for dietary fiber gross weight 70%~75%；The weight of the liposoluble vitamin accounts for the 10%~40% of vitamin gross weight；The protein is accounted for always Energy 20~30%, fat accounts for the 10~25% of gross energy, carbohydrate and accounts for the 50~60% of gross energy.

Embodiment 2

Hepatopathy tailored version clinical nutrition formula of the present invention includes PURE WHEY 14.64g, soybean protein isolate 8.18g, whole milk powder 10g, dried whole-egg 0.18g, bovine colostrum 0.1g, taurine 0.12g, soy oligosaccharides Gly-His-Lys 0.1g, ocean Fish oligopeptide powder 0.1g；Olive oil 0.39g, soybean oil 0.63g, coconut oil 0.39g, perilla herb oil 0.27g, medium chain triglyceride 3.03g, single diglycerine fatty acid ester 0.09g；Maltodextrin 33.4g, tapioca 11.63g；Resistant dextrin 2.7g, oligomeric half Lactose 0.54g, inulin 0.9g, oligoisomaltose 0.91g；Calcium 0.15g, phosphorus 0.256g, potassium 0.093g, sodium in macroelement 0.177g, magnesium 0.177g；Iron 0.011g, zinc 0.007g in trace element；Vitamin A 0.004g, beta carotene 0.017g, dimension Raw element D₃0.0005g, vitamin E 0.009g；Vitamin B₁0.001g, vitamin B₂0.001g, vitamin B₆ 0.001g、 Vitamin B₁₂0.00013g, vitamin C 0.127g, pantothenic acid 0.003g, folic acid 0.00017g, nicotinic acid 0.0133g；Coixlacrymajobi powder 0.09g, oatmeal 0.09g, buckwheat 0.09g, red bean powder 0.09g, carrot meal 0.09g, broccoli powder 0.09g, white fungus powder 0.09g, salmon powder 0.09g, powdered beef 0.09g, red date powder 0.09g；Peppermint 0.09g, Poria cocos 0.09g, matrimony vine 0.09g, wood Melon 0.09g, Chinese yam 0.09g, mulberries 0.09g, spina date seed 0.09g, citron 0.07g；L-cn in natural plants compound 0.64g；Swan-mussel polysaccharide 0.02g in new resource food；Wherein, the weight of the water-soluble dietary fiber accounts for dietary fiber gross weight 70%~75%；The weight of the liposoluble vitamin accounts for the 10%~40% of vitamin gross weight；The protein is accounted for always Energy 20~30%, fat accounts for the 10~25% of gross energy, carbohydrate and accounts for the 50~60% of gross energy.

Embodiment 3

Hepatopathy tailored version clinical nutrition formula of the present invention includes PURE WHEY 14.64g, soybean protein isolate 8.18g, whole milk powder 10g, dried whole-egg 0.18g, bovine colostrum 0.1g, taurine 0.12g, soy oligosaccharides Gly-His-Lys 0.1g, ocean Fish oligopeptide powder 0.1g；Olive oil 0.39g, soybean oil 0.63g, coconut oil 0.39g, perilla herb oil 0.27g, medium chain triglyceride 3.03g, single diglycerine fatty acid ester 0.09g；Maltodextrin 33.4g, tapioca 11.63g；Resistant dextrin 2.7g, oligomeric half Lactose 0.54g, inulin 0.9g, oligoisomaltose 0.91g；Calcium 0.15g, phosphorus 0.256g, potassium 0.093g, sodium in macroelement 0.177g, magnesium 0.177g；Iron 0.011g, zinc 0.007g in trace element；Vitamin A 0.004g, beta carotene 0.017g, dimension Raw element D₃0.0005g, vitamin E 0.009g；Vitamin B₁0.001g, vitamin B₂0.001g, vitamin B₆ 0.001g、 Vitamin B₁₂0.00013g, vitamin C 0.127g, pantothenic acid 0.003g, folic acid 0.00017g, nicotinic acid 0.0133g；Coixlacrymajobi powder 0.09g, oatmeal 0.09g, buckwheat 0.09g, red bean powder 0.09g, carrot meal 0.09g, broccoli powder 0.09g, white fungus powder 0.09g, salmon powder 0.09g, powdered beef 0.09g, red date powder 0.09g；Peppermint 0.09g, Poria cocos 0.09g, matrimony vine 0.09g, wood Melon 0.09g, Chinese yam 0.09g, mulberries 0.09g, spina date seed 0.09g, citron 0.07g；L-cn in natural plants compound 0.5g；Swan-mussel polysaccharide 0.01g in new resource food；Wherein, the weight of the water-soluble dietary fiber accounts for dietary fiber gross weight 70%~75%；The weight of the liposoluble vitamin accounts for the 10%~40% of vitamin gross weight；The protein is accounted for always Energy 20~30%, fat accounts for the 10~25% of gross energy, carbohydrate and accounts for the 50~60% of gross energy.

Embodiment 4

The preparation method of hepatopathy tailored version clinical nutrition formula containing embodiment 1- embodiments 3 is as follows：

1) powdered oil (powder fat) is prepared：

A) the wall material aqueous solution is prepared：Take 10.5 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, meals fine 2 grams of dimension (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, Arab 0.2 gram of glue, 50 milliliters of water stir and (have ready conditions and heat while stirring to 60 DEG C, room temperature is cooled to after being kept for 30 minutes).

B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 4.5 milliliters of greases monoglyceride 0.37 milliliter, it is 0.59 milliliter of soybean oil, 0.37 milliliter of coconut oil, 0.25 milliliter of perilla herb oil, 2.84 milliliters of medium chain triglyceride, single 0.08 milliliter of diglycerine fatty acid ester).

C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80.

D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.

E) addition stabilizer agar takes 0.1 gram (total solid concentration is 0.2%) to enter after mixed solution, is settled to water Disperse 2 minutes at a high speed under 200 milliliters (total solid concentration is 25%), 20000r/min.

F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).

G) obtained emulsion is spray-dried, EAT is 195 DEG C, leaving air temp is 80 DEG C.Collect powder Grease (powder fat).

2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, add weight be raw material weight 3~8 times of water, carry out immersion 3~4 hours, then to soak Carry out decocting 30~60min, filtering removes raw material, leaves and takes decoction liquor, be spray-dried decoction liquor, with 60~80 mesh sieves point Prepare integration of drinking and medicinal herbs component powders；

3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from carragheen, I Primary glue carries out 2 emulsifying homogeneous processing, the emulsifying homogeneous time is 10~15min, is then sprayed under high pressure as wall material It is instantaneous to dry, prepare liposoluble vitamin powder with 60~80 mesh sieves point；Using the water soluble vitamin of predetermined weight number as Core, from maltodextrin, lipoprotein as wall material, is well mixed, and spraying is instantaneous to be dried, and is prepared with 60~80 mesh sieves point water-soluble Property vitamin powder；

4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；

5) by step 1)~step 4) obtained by powder sequentially add the mixers of cone-type mixer or other forms and mix Uniformly obtained formula mixture is closed, it is standby after sterilization processing；

6) according to conventional technical means by step 5) in formula mixture be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral liquid.

In step 6) in, optionally increase appropriate food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, flavoring essence spices, brown sugar；More preferably carragheen, Arabic gum, Guar Glue, Aspartame, flavoring essence spices.

Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent production The danger of green powder blast.

Embodiment 5

The nutrient powder for taking the embodiment of the present invention 1~3 to prepare is tested, while setting comparative example 1, comparative example 2 and blank pair According to group, comparative example 1 is using nutrient powder prepared by new resource food is deleted in the nutrient formulation of embodiment 2, comparative example 2 is using implementation Nutrient powder prepared by integration of drinking and medicinal herbs composition, blank control group gavage physiological saline are deleted in the nutrient formulation of example 2.

1) the formula tailored version clinical nutrition that the present invention is provided is formulated the influence to mouse normal growth.

SPF grades of BALB/C mices, male and female half and half, body weight 25~30g, every group 10.Filled daily according to 0.2g/10g dosage Stomach mouse, continuous 30 days.Single cage is fed during to mouse stomach, and it is determined daily and takes in appetite, claims 1 body weight within every 3 days, finally Each group increased weight is calculated, 1 is shown in Table.

The hepatopathy tailored version clinical nutrition of table 1 is formulated the influence to mouse weight

Group	First body weight/g	Whole body weight/g	Weightening/g
				Embodiment 1	26.3	44.2	17.9
Embodiment 2	28.1	46.8	18.7
				Embodiment 3	27.8	45.9	18.1
Comparative example 1	25.8	42.3	16.5
				Comparative example 2	26.9	42.6	15.7
Control group	27.4	41.6	14.2

Table 1 understands that the nutrient formulation has no to mouse weight growth and significantly affected, and can maintain the normal physiological work(of mouse Can, harmful effect is not produced to the normal growth of mouse.

2) the formula tailored version clinical nutrition that the present invention is provided is formulated to CC1₄The influence of subacute hepatic injury mouse.

Cleaning grade SPF grades of male BALB/C mice 50,20~25g of body weight.Mouse using chow diet feed 1 week after with Machine is divided into blank control group, CC1₄Model group and low dose group (20g/kg), middle dose group (40g/kg), high dose group (80g/ Kg), every group 10.The nutrient powder that wherein low dose group, middle dose group and high dose group are prepared using embodiment 2.

Normal group and CC1 during experiment₄Model group is freely ingested drinking-water, basal feed normal supply；Three dosage Group gives nutrient powder 20g/kg, 40g/kg, 80g/kg respectively daily, and feed nutrient powder gives basal feed, continuous 7 after terminating Week, drinking-water of freely ingesting.

The induction of subacute liver injury model：In addition to blank control group, remaining four groups of animal abdominal cavity from testing the 1st day is noted Penetrate 0.3% CC1₄Corn oil, dosage is 10ml/kg, is injected 2 times weekly, co-injection 3 weeks, sub- anxious with induced chemical Property liver damage animal model.Final injection CC1₄Fasting 8 hours afterwards, retroorbital venous clump adopts hematometry serum glutamic pyruvic transminase (ALT) and glutamic-oxalacetic transaminease (AST) level, evaluate whether liver injury model induces success.Liver injury model induces successful subsequent It is continuous to give feeding by former scheme.After 7 weeks, each group mouse fasting 12 hours extracts eyeball blood sampling and prepares serum, determine ALT and AST, its experimental result is as shown in table 2.

The nutrient formulation of table 2 is to CC1₄The influence of subacute hepatic injury mice serum liver enzyme activity.

As a result show, mouse is carried out after the induction 3 weeks of subacute liver injury model, with blank control group ratio, hepatic injury mould Type group Serum ALT, AST activity are significantly raised, and the liver enzyme activity in each dosage group and model group ratio, serum has becoming for reduction Gesture.Continue to mouse feeding to 7 weekends, model group Serum ALT, AST activity are still significantly higher than blank control group；With model group phase Than each dosage group of feed nutrient powder then can significantly suppress CC1₄The rise of caused Serum ALT and AST, this shows this hair Bright nutrient formulation is to CC1₄Subacute hepatic injury mouse has liver injury protection effect.

The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it is any to the practicality carry out equivalent modifications and replace In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and repaiied Change, all should be contained within the scope of the invention.

Claims

1. a kind of hepatopathy tailored version clinical nutrition formula, it is characterised in that including following component：Protein, fat, carbon hydrate Thing, dietary fiber, macroelement, trace element, vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and New resource food；

Wherein, the new resource food includes swan-mussel polysaccharide；

Wherein, the integration of drinking and medicinal herbs composition includes peppermint, Poria cocos, matrimony vine, pawpaw, Chinese yam, mulberries, spina date seed, citron.

2. a kind of hepatopathy tailored version clinical nutrition formula according to claim 1, it is characterised in that also thickened including food Agent and food additives, the food thickening agent be guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, At least one of gelatin, Arabic gum, the food additives be Aspartame, flavoring essence spices, brown sugar at least It is a kind of.

3. a kind of hepatopathy tailored version clinical nutrition formula according to claim 1, it is characterised in that the vitamin is water Soluble vitamin and liposoluble vitamin, the weight of the liposoluble vitamin account for the 10%~40% of vitamin gross weight.

4. a kind of hepatopathy tailored version clinical nutrition formula according to claim 1, it is characterised in that the dietary fiber is Water-soluble dietary fiber and insoluble dietary fiber, wherein the weight of the water-soluble dietary fiber accounts for dietary fiber gross weight 70%~75%.

5. a kind of hepatopathy tailored version clinical nutrition formula according to claim 1, it is characterised in that the weight of the component Number is：20~30 parts of protein, 5~15 parts of fat, 45~55 parts of carbohydrate, 2~8 parts of dietary fiber, macroelement 0.6~1.2 part, 0.01-0.06 parts of trace element, 0.05~0.25 part of vitamin, 0.5~1.5 part of meals elite, integration of drinking and medicinal herbs 0.01-0.1 parts of 0.1~6 part of composition, 0.1-1 parts of natural plants compound and new resource food；Wherein described protein is accounted for always Energy 20~30%, fat accounts for the 10~25% of gross energy, carbohydrate and accounts for the 50~60% of gross energy.

6. a kind of hepatopathy tailored version clinical nutrition formula according to claim 5, it is characterised in that the integration of drinking and medicinal herbs into The parts by weight of each component are as follows in point：0~1 part of peppermint, 0~1 part of Poria cocos, 0~1 part of matrimony vine, 0~1 part of pawpaw, Chinese yam 0~1 Part, 0~1 part of mulberries, 0~1 part of spina date seed, 0~1 part of citron.

7. a kind of preparation method being formulated such as hepatopathy tailored version clinical nutrition according to any one of claims 1 to 6, its feature It is, comprises the following steps：

Step 1: by the protein of predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, trace element, It is 150~250 μm that vitamin, integration of drinking and medicinal herbs composition, natural plants compound and new resource food are prepared into particle diameter respectively Powder；

Step 3: being prepared into nutrient powder, nutrition emulsion, capsule, tablet, ball using the powder being well mixed in the step 2 At least one of agent or oral liquid；

Wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, water extraction is concentrated, and concentrate progress spray drying is made into medicine Eat homologous component powders；