CN107319524A - A kind of nephrosis tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of nephrosis tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN107319524A
CN107319524A CN201710516559.3A CN201710516559A CN107319524A CN 107319524 A CN107319524 A CN 107319524A CN 201710516559 A CN201710516559 A CN 201710516559A CN 107319524 A CN107319524 A CN 107319524A
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parts
powder
nephrosis
clinical nutrition
tailored version
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尤俊
季敬东
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SHANGHAI FUDAN AOYI MEDICAL TECHNOLOGY CO LTD
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SHANGHAI FUDAN AOYI MEDICAL TECHNOLOGY CO LTD
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of nephrotic's tailored version clinical nutrition formula, it includes 8 15 parts of protein, 8 12 parts of fat, 55 65 parts of carbohydrate, 35 parts of dietary fibers, 0.5 1.5 parts of part macroelements, 0.01 0.04 parts of part trace elements, 0.005 0.015 parts of liposoluble vitamins, 0.01 0.2 parts of water soluble vitamins, 0.05 1 parts of meals elite, 0.05 2 parts of integration of drinking and medicinal herbs compositions, 0.1 3 parts of natural plants compounds and 0.005 2 parts of new resource foods, wherein integration of drinking and medicinal herbs composition is selected from Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, balloonflower root, Gorgon fruit, Chinese yam, at least one of oyster；Above-mentioned each component is previously prepared into powder, wherein fat and vitamin are prepared into powder using micro-capsule embedding techniques.Screening and proportioning by said components, nutrient formulation of the present invention provides more reasonable, comprehensive nutritional support for nephrotic, to improve the condition of nephrotic, the composition of nourishing liver and kidney, strengthening the essence blood-nourishing and strengthen immunity is added simultaneously, delay progression of disease, improve the quality of living, extend the life-span.

Description

A kind of nephrosis tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food field, and in particular to a kind of nephrosis tailored version clinical nutrition formula And preparation method thereof.
Background technology
Kidney is the vitals in human body with excretion, metabolism and endocrine function, and it can be each histoorgan of human body The metabolic waste of various metabolites, particularly protein produced by metabolic process, is excreted by urine, is maintained The balance of human body water, electrolyte and soda acid, therefore, kidney is to having very important effect to body metabolism.
Nephrosis refers to clinically various acute and chronic kidney troubles and secondary to acute and chronic caused by other systems disease Renal dysfunction is until renal failure.Clinically common mainly chronic kidney disease (CKD) patient.No matter chronic kidney disease refers to Which kind of reason, simply by the presence of renal damage or decreased renal function, and the duration was more than 3 months, and all diagnosable is chronic kidney Disease.CKD includes primary and Secondary cases kidney trouble, such as various renal glomerular diseases, latent nephritis, pyelonephritis, anaphylaxis Purpura ephritis, lupus erythematosus nephritis, gout kidney, IgA nephrosis, nephrotic syndrome, membranous nephropathy, nephrotic syndrome, diabetogenous nephrosis Disease, hypertensive nephropathy, polycystic kindey etc..
In CKD early stages, patient will not generally show any obvious symptom, but in CKD late periods, patient it is possible that Following sings and symptoms：Number of micturitions increase, especially at night；Physical efficiency level declines；Notice can not be concentrated；Appetite is poor； Nausea and vomiting；Trick swelling；Dry skin, itch；Dyscoimesis；Muscle cramp, especially at night.CKD is generally in progress Slowly, it is and usually irreversible.Diabetes especially type II diabetes (T2DM) and hypertension are two of CKD main Reason.
In recent years, with aging population progress faster, the incidence of disease and the illness rate increase of various kidney troubles, CKD exist It is distributed in global range, maintains essentially in annual growth 7%-8%.It is estimated that the illness rate in more than 30 years old crowd is 7.2%.
At present, for the treatment of chronic kidney disease, mainly including such as haemodialysis, peritonaeum of drug therapy, renal replacement therapies Dialysis, kidney transplant etc..The expense of these treatments is greatly increased, and brings serious economy and social concern.
2001, NKF delivered detection and guideline of prevention and treatment, the kidney trouble of chronic renal disease progress Quality of life instructs (K/KOQI), proposes the integrated therapeutic theory of chronic renal disease, including delays kidney trouble progress, subtracts The complication such as few cardiovascular complication, reduction malnutrition, anaemia, hypertension, osteopathy, improve survival rate, quality of life and society What can be lived returns to rate.In the theory of integrated therapeutic, there are the multinomial and nutrition such as reasonable diet, control blood pressure, reduction blood fat The relevant content for the treatment of, it was confirmed that status of the nutrition treatment in the complex treatment of chronic renal disease.
Therefore, in addition to by correct clinical treatment, rational diet, which coordinates, can delay progression of disease, improve life matter Amount, extends the life-span.Therefore, develop can provide basal nutrient needed for nephrotic it is plain while, and can supplement to improve and treat The product of effect, with important value and wide market.
The content of the invention
It is an object of the invention to overcoming defect of the prior art to be formulated there is provided a kind of nephrosis tailored version clinical nutrition and Its preparation method, it reduces Urine proteins by the nutrition treatment of low protein diet, reduces serium inorganic phosphorus, slow down glomerulosclerosis, simultaneously Nourishing liver and kidney, strengthening the essence blood-nourishing the integration of drinking and medicinal herbs composition of addition, so as to delay the development and deterioration of the state of an illness, improves patient vitals' matter Amount, mitigates family and burden on society.
To achieve the above object, the present invention is adopted the following technical scheme that：
On the one hand, the present invention provides a kind of nephrosis tailored version clinical nutrition formula, including following component and its parts by weight： 8-15 parts of protein, 8-12 parts of fat, 55-65 parts of carbohydrate, 3-5 parts of dietary fibers, 0.5-1.5 parts of macroelements, 0.01-0.04 parts of trace elements, 0.005-0.015 parts of liposoluble vitamins, 0.01-0.2 parts of water soluble vitamins, 0.05-1 parts Meals elite, 0.05-2 parts of integration of drinking and medicinal herbs compositions, 0.1-3 parts of natural plants compounds and 0.005-2 parts of new resource foods；Its In, the integration of drinking and medicinal herbs composition in Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, balloonflower root, Gorgon fruit, Chinese yam, oyster extremely Few one kind；Wherein, the protein includes the small protein that mean molecule quantity is below 1000D.
In order to further optimize above-mentioned technical proposal, the technical measures that the present invention is taken also include：
Preferably, the protein be selected from PURE WHEY, hydrolysis Isin glue collagen, soybean protein isolate, whole milk powder, At least one of dried whole-egg, lactoferrin, colostrum, amino acid, protein peptides；
Wherein, the amino acid is selected from 1B-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, ILE, L-Leu；The protein peptides are selected from soy oligosaccharides At least one of peptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide, laughable peptide, amino peptide, ovalbumin peptide.
Preferably, the small protein is of animal or plant nature oligopeptide, and it includes soybean oligopeptide and marine fish is oligomeric Peptide.
It is highly preferred that the protein includes PURE WHEY, whole milk powder, dried whole-egg, colostrum, taurine, soybean Oligopeptide, ocean fish oligopeptide.
Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically it is described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm Oil, butter, cream, lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil etc.；More preferably olive oil, soybean oil, coconut Oil, perilla herb oil, medium chain triglyceride.
Preferably, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch, jade At least two in rice starch；More preferably maltodextrin, tapioca, cornstarch.
Preferably, the dietary fiber comprising inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one of soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；It is highly preferred that the dietary fiber is water solubility Dietary fiber, it at least includes bag galactooligosaccharide and oligoisomaltose.
Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate At least one of with magnesium gluconate.
Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.
Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, vitamin K1At least one of.
Preferably, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin At least one of C, pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean At least one of powder, soy meal；The potato class is mainly made up of common yam rhizome powder；The Vegetable powder is selected from carrot meal, white radish powder, south At least one of melon powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae be selected from mushroom powder, Kelp Powder and At least one of white fungus powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch；The fish and shrimp Selected from least one of salmon powder and cod meal；The poultry meat in chicken meal, powdered beef and pig kidney powder extremely Few one kind；The fruits are selected from least one of red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder；More Preferably millet powder, mung bean flour, white fungus powder, broccoli powder, salmon powder.
Preferably, the integration of drinking and medicinal herbs composition is selected from Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, balloonflower root, Gorgon euryale At least one of reality, Chinese yam, oyster；More preferably selected from Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, balloonflower root, Gorgon fruit, Chinese yam.
Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one of sterol, lycopene, resveratrol, allicin；More preferably l-cn.
Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo In leaf flavones, CPP, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii, xylo-oligosaccharide At least one；More preferably avenabeta glucosan.
Preferably, the parts by weight of the of animal or plant nature oligopeptide are 0-1 parts.
Preferably, the fat contains 0-2 parts of Purple Perilla Seed Oil, 2-4 parts of medium chain triglyceride
Preferably, the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：0~1 part of Fermented Soybean, Poria cocos 0~1 Part, 0~1 part of raspberry, 0~1 part of matrimony vine, 0~1 part of sealwort, 0~1 part of balloonflower root, 0~1 part of Gorgon fruit, 0~1 part of Chinese yam, oyster 0 ~1 part；More preferably 0.01~1 part of Fermented Soybean, 0.01~1 part of Poria cocos, 0.01~1 part of raspberry, 0.01~1 part of matrimony vine, yellow 0.01~1 part of essence, 0.01~1 part of balloonflower root, 0.01~1 part of Gorgon fruit, 0.01~1 part of Chinese yam.
On the other hand, the present invention also provides a kind of preparation method method of above-mentioned nephrosis tailored version clinical nutrition formula, its Comprise the following steps：
Step 1) fat powder, liposoluble vitamin powder and water soluble vitamin powder are prepared using micro-capsule embedding techniques End；
Step 2) integration of drinking and medicinal herbs component powders are prepared using crushing, alcohol extracting, water extraction, spray drying and sifting step；
Step 3) protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals are smart China, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；
Step 4) by step 1)-step 3) and obtained by powder sequentially add mixer it is well mixed after formula mixing is made Thing, it is standby after sterilization processing；
Step 5) according to conventional technical means by step 4) in formula mixture be prepared into nutrient powder, nutrition emulsion, glue At least one of wafer, tablet, pill or oral liquid；
Wherein, step 1) -3) order can mutually change.
Finally, the present invention relates to a kind of product prepared by above-mentioned nephrosis tailored version clinical nutrition formula, including nutrient powder, Nutrition emulsion, capsule, tablet, pill, oral liquid etc..
In above-mentioned preparation method, wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, alcohol extracting concentration, water extraction are dense Contracting, and integration of drinking and medicinal herbs component powders are made in concentrate progress spray drying；Wherein, the vitamin and fat are respectively by micro- Encapsulated processing is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, adds 4~6 times of 50~80% second that weight is raw material weight Alcohol, is soaked, is extracted 2 times, is merged alcohol extract and is concentrated into no alcohol taste；The active compound dregs of a decoction are flung to after ethanol, and it is original to add weight 6~8 times of water of material weight is soaked, and soak is carried out to decoct 30~60min, filtering removes raw material, leaves and takes decoction Liquid；Merge alcohol extract and decoction liquor after concentration, and it is spray-dried, it is same finally to prepare medicine food with 60~80 mesh sieves point Derived components powder.
Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) it regard liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer are as wall material, high-pressure homogeneous emulsification, and spraying is instantaneous to be dried, with 60~80 mesh sieves Divide and prepare liposoluble vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, OK a karaoke club Glue, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum One or more works in powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer For wall material, it is well mixed, spraying is instantaneous to be dried, and water soluble vitamin powder is prepared with 60~80 mesh sieves point.
Preferably, the specific implementation step of the fatty micro-capsule embedding techniques is as follows：By fat, emulsifying agent, wall material with Water mixed dissolution prepares emulsion；After the stirring mixing of above-mentioned emulsion, emulsifying homogeneous processing is carried out, spraying is then carried out dry Dry, screening prepares fat powder, and fat powder is compared with conventional grease, and its dispersiveness, water solubility, emulsibility, inoxidizability are all Improve a lot；Wherein, the emulsifying agent be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), One in sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin, monoglyceride, Tween 80 Plant or a variety of；The wall material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, fat egg In vain, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean One or more in fiber, lactose, candy sugar powder, emulsifying agent, stabilizer.
Being used in the present invention includes Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, balloonflower root, Gorgon fruit, Chinese yam, the medicine of oyster Same derived components are eaten, mentioned component has functions that nourishing liver and kidney, strengthening the essence blood-nourishing.
Fermented Soybean mainly contains protein, fat, carbohydrate, the composition such as vitamin, its isoflavones being rich in tool There is obvious anti-oxidant, cancer-resisting, prevent angiocardiopathy etc. from acting on, and contained farnoquinone -7 helps to prevent bone Matter is loose.
Poria cocos can clearing damp and promoting diuresis, have function of invigorating spleen again, transmitting and distributing the fluids be unable to for insufficiency of the spleen, stop the disease that phlegm and retained fluid is given birth in dimerization, With therapeutic action；Poria cocos energy mental-tranquilization, therefore available for diseases such as confused and worried, palpitaition, insomnias；Poria cocos also has certain resist Cancer, antitumor action and raising humoral immune function.
Raspberry is the dry fruit of rosaceous plant rubus chingii Hu, with kidney-nourishing, controlling nocturnal emission with astringent drugs, contracting urine effect, for kidney The treatment of the diseases such as the empty enuresis, frequent urination, impotence and premature ejaculation, emission and spermatorrhea.Raspberry aqueous extract can reduce experimental rat inferior colliculus Brain LHRH, hypophysis LH, FSH and sexual gland E2 contents, and improve thymus gland LHRH and blood T levels.Research shows raspberry Aqueous extracts It is probably the pharmacological basis of its " the puckery essence of kidney tonifying " to the regulating and controlling effect of gonad axis.
LBP-X has repair to hepatic injury caused by carbon tetrachloride in matrimony vine, and its mechanism may be by prevention The damage of matter net, promotes protein synthesis and detoxication, recovers the function of liver cell, and promote liver cell regeneration；Matrimony vine is thick Polysaccharide can reduce hepatic tissue mda content, and carbon tetrachloride hepatic injury mouse liver glycogen content can be made significantly to raise, and improve human body Energy reserve；The active ingredient in matrimony vine can improve mitochondrial form to alcoholic liver disease of rats model, mitigate liver simultaneously The steatosis and inflammation degree of necrosis of cell.
Sealwort has resisting pathogenic microbes effect, and sealwort decoction is given while tulase is infected with significant antibacterial Effect, and health status can be improved, it has suppression to make to Grain-negative typhoid bacillus and Grain-positive staphylococcus aureus With；Sealwort methanolic extract can be significantly to the blood glucose rise caused by antiadrenergic drug, with certain blood sugar reducing function；Sealwort Methanolic extract can substantially increase the convergent force of rat atrial flesh；Sealwort decoction is to triglycerides, beta lipoprotein and cholesterolemia There is obvious reduction to act on；Sealwort has certain influence to cellular immunity, humoral immunity, can improve lymphocyte transformation rate, be conducive to The formation of antibody.
Balloonflower root has eliminating the phlegm, antibechic, anti-inflammatory, hypotensive, hypoglycemic, fat-reducing, antitumor, raising body immunity etc. extensively Pharmacological activity.
There is Gorgon fruit the strong, tonifying middle-Jiao and Qi of nourishing, appetizing to quench the thirst, foster essence etc. of reinforcing the kidney effect；Gorgon fruit can strengthen small intestine suction Function is received, urine xylose excretion rate is improved, increases serum concentration of carotene, the raising of serum carotenoid levels can make lung cancer, stomach The morbidity risk rate of cancer declines, and greatly reduces the chance of cancer generation；Gorgon fruit contains abundant starch, can provide heat energy for human body, And contain multivitamin and carbonizable substance, it is ensured that composition needed for endotrophic.
Chinese yam especially Chinese yam polysaccharide has good immunoregulation effect, and Chinese yam can extend the low mouse of immunity function The hypoxic tolerance time, improve spleen index, thymus index (P<0.05) thymus gland, the institutional framework of spleen, are improved.
Oyster nutrition liquid energy significantly reduces the blood urea nitrogen and blood lactase acid level of mouse, improves blood lactase acid resume speed, together When can significantly extend the mice burden swimming time, oyster nutrient solution has antifatigue effect.
Compared with prior art, the invention has the advantages that：
(1) present invention reduces Urine proteins by the nutrition treatment of low protein diet, reduces serium inorganic phosphorus, slows down glomerulosclerosis, Nourishing liver and kidney, strengthening the essence blood-nourishing integration of drinking and medicinal herbs composition is added simultaneously, each nutritional ingredient complements each other, and determined curative effect can improve The condition of disease treatment nephrotic, so as to delay the development and deterioration of the state of an illness, improves Quality of Life of Patients, mitigate family and Burden on society.
(2) present invention also adds of animal or plant nature oligopeptide, and oligopeptide refers to mean molecule quantity for below 1000D, by life The small molecule protein of thing enzyme engineering technology separation and Extraction from animal or vegetable protein, with it is soluble in water, to acid, heat Stable the characteristics of, digestion is not required in human body directly to be absorbed, and bioavailability is high.Oligopeptide, which is removed, has corresponding nutrition work( Can be outer, also with a series of physiological active functionses：Promote the absorption of electrolyte and supplement, anti-sports fatigue, improve immunity, auxiliary Help the effect such as regulation blood pressure blood fat, anti-oxidant, antitumor, promotion bone growth；And the present invention uses low protein content, it is adapted to kidney Patient takes.
(3) present invention also addition prebiotics galactooligosaccharide, oligoisomaltose；Prebiotics can promote probiotics enteron aisle Field planting, enteron aisle convergence, reduction enteron aisle PH environment, promote the growth and breeding of human body beneficial bacteria, so as to suppress corrupt bacteria growing, have Help improve and maintain enteron aisle normal function；Long-term consumption can improve immunity, mitigate burden of liver, anti-aging, promotion Defecation.
(4) the vitamin and mineral reference that the present invention is used《Special medicine purposes formula food general rule》Perform there is provided Water soluble vitamin needed by human, liposoluble vitamin, macroelement and trace element.
(5) present invention also adds Purple Perilla Seed Oil, with fat-reducing, reduction cholesterol, improves the effect such as renal function；In addition Chain triglyceride, available for treatment hyperplasia of prostate, dissipation cholelith, reduction cholesterol, anti-curing hyperlipemia.
(6) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, it is easy to be well mixed with other powdered components；And use micro-capsule bag Bury after technology, grease is embedded in wall material, so that the contact with air is avoided to strengthen inoxidizability, so as to play guarantor The maximum effect of strong type grease.
(7) raw material of nephrosis tailored version clinical nutrition of the present invention formula in preparation process it is previously prepared into 150~250 μm of powder, this make it that, when preparing finished product, each nutrition composition can be well mixed, it is ensured that each in unit volume The content of nutrition composition is essentially identical, while when preparing liquid type preparation, each nutrition composition can be fully dispersed and is completely dissolved Into solvent, prevent occurring solid precipitation in liquid, effect of finished product product has been effectively ensured.
The present invention is by from rational basal nutrient element, using the proportioning of general equilibrium, while addition has nourishing liver The specific nutrients such as integration of drinking and medicinal herbs composition, natural plants compound, the new resource food of kidney, strengthening the essence blood-nourishing and strengthen immunity, And its proportioning and basal nutrient element progress compatibility synergy are adjusted, so that the nutrient formulation of allotment is easier to be disappeared by nephrotic Change and absorb, give full play to effect of its component, improve the condition of nephrotic, delay progression of disease, improve the quality of living, Extend the life-span.
Embodiment
The present invention provides a kind of clinical nutrition formula special for nephrosis, including following component and its parts by weight：8- 15 parts of protein, 8-12 parts of fat, 55-65 parts of carbohydrate, 3-5 parts of dietary fibers, 0.5-1.5 parts of part macroelements, 0.01-0.04 parts of part trace elements, 0.005-0.015 parts of liposoluble vitamins, 0.01-0.2 parts of water soluble vitamins, 0.05- 1 part of meals elite, 0.05-2 parts of integration of drinking and medicinal herbs compositions, 0.1-3 parts of natural plants compounds and 0.005-2 portions of new resources foods Product.
With reference to embodiment, the embodiment to the present invention is further described.Following examples are only used for more Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.
Embodiment 1
The special clinical nutrition formula of nephrosis of the present invention includes PURE WHEY 11.2g, whole milk powder 4g, shell egg Powder 0.18g, colostrum 0.09g, taurine 0.12g；Soybean oligopeptide 0.1g, ocean fish oligopeptide 0.1g, olive oil 1.58g, Soybean oil 2.55g, coconut oil 1.58g, perilla herb oil 0.36g, medium chain triglyceride 3.64g；Maltodextrin 43.52g, tapioca 9.45g, cornstarch 7.27g；Water-soluble dietary fiber 4.55g in dietary fiber；Calcium 0.53g in macroelement, phosphorus 0.23g, Potassium 0.05g, sodium 0.15g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.016g in trace element；In liposoluble vitamin Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D30.000001g, vitamin E 0.008g；Water soluble vitamin Vitamin B in raw element10.001g, vitamin B20.001g, vitamin B60.0002g, vitamin B120.000001g, dimension life Plain C 0.102g, pantothenic acid 0.003g, folic acid 0.000023g, nicotinic acid 0.0133g；Millet powder 0.1g, mung bean flour 0.1g, white fungus powder 0.1g, broccoli powder 0.1g, salmon powder 0.1g, Fermented Soybean 0.1g, Poria cocos 0.1g, raspberry 0.1g, matrimony vine 0.1g, sealwort 0.1g, balloonflower root 0.1g, Gorgon fruit 0.1g, Chinese yam 0.1g, l-cn 0.64g, avenabeta glucosan 0.02g.
Embodiment 2
The special clinical nutrition formula of nephrosis of the present invention includes PURE WHEY 9.1g, whole milk powder 4g, shell egg Powder 0.18g, colostrum 0.09g, taurine 0.12g, soybean oligopeptide 0.1g, ocean fish oligopeptide 0.1g；Olive oil 1.58g, Soybean oil 2.55g, coconut oil 1.58g, perilla herb oil 0.36g, medium chain triglyceride 3.64g；Maltodextrin 45.72g, tapioca 9.45g, cornstarch 7.27g；Water-soluble dietary fiber 4.55g in dietary fiber；Calcium 0.53g in macroelement, phosphorus 0.23g, Potassium 0.05g, sodium 0.15g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.016g in trace element；In liposoluble vitamin Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D30.000001g, vitamin E 0.008g；Water soluble vitamin Vitamin B in raw element10.001g, vitamin B20.001g, vitamin B60.0002g, vitamin B120.000001g, dimension life Plain C 0.102g, pantothenic acid 0.003g, folic acid 0.000023g, nicotinic acid 0.0133g；Millet powder 0.1g, mung bean flour 0.1g, white fungus powder 0.1g, broccoli powder 0.1g, salmon powder 0.1g, Fermented Soybean 0.1g, Poria cocos 0.1g, raspberry 0.1g, matrimony vine 0.1g, sealwort 0.1g, balloonflower root 0.1g, Gorgon fruit 0.1g, Chinese yam 0.1g, l-cn 0.64g, avenabeta glucosan 0.02g.
Embodiment 3
The special clinical nutrition formula of nephrosis of the present invention includes PURE WHEY 11.2g, whole milk powder 4g, shell egg Powder 0.18g, colostrum 0.09g, taurine 0.12g, soybean oligopeptide 0.1g, ocean fish oligopeptide 0.1g；Olive oil 1.58g, Soybean oil 2.55g, coconut oil 1.58g, perilla herb oil 0.36g, medium chain triglyceride 3.64g；Maltodextrin 43.52g, tapioca 9.45g, cornstarch 7.27g；Water-soluble dietary fiber 4.55g in dietary fiber；Calcium 0.53g in macroelement, phosphorus 0.23g, Potassium 0.05g, sodium 0.15g, magnesium 0.15g；Iron 0.011g, iodine 0.00014g, zinc 0.016g in trace element；In liposoluble vitamin Vitamin A 0.0005g, beta carotene 0.000057g, vitamin D30.000001g, vitamin E 0.008g；Water soluble vitamin Vitamin B in raw element10.001g, vitamin B20.001g, vitamin B60.0002g, vitamin B120.000001g, dimension life Plain C 0.102g, pantothenic acid 0.003g, folic acid 0.000023g, nicotinic acid 0.0133g；Millet powder 0.1g, mung bean flour 0.1g, white fungus powder 0.1g, broccoli powder 0.1g, salmon powder 0.1g, Fermented Soybean 0.01g, Poria cocos 0.01g, raspberry 0.01g, matrimony vine 0.01g, Huang Smart 0.01g, balloonflower root 0.01g, Gorgon fruit 0.01g, Chinese yam 0.01g, l-cn 0.64g, avenabeta glucosan 0.02g.
Embodiment 4
A kind of preparation method of the special clinical nutrition formula of nephrosis as described in 1~embodiment of embodiment 3 is as follows：
1) powdered oil (powder fat) is prepared：
A) the wall material aqueous solution is prepared：Take 8 grams of maltodextrin, 4 grams of soybean protein isolate, 11 grams of whole-fat milk powder, dietary fiber 2 Gram (resistant dextrin), 0.5 gram of inulin, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, Arabic gum 0.2 gram, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stirs and (has ready conditions and heat while stirring to 60 DEG C, kept for 30 points Room temperature is cooled to after clock).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (olive oil in 9.11 milliliters of greases monoglyceride 1.48 milliliters, 2.39 milliliters of soybean oil, 1.48 milliliters of coconut oil, 0.34 milliliter of perilla herb oil, 3.42 milliliters of medium chain triglyceride).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1 gram (total solid concentration is 0.2%) to enter after mixed solution, is settled to water Disperse 2 minutes at a high speed under 200 milliliters (total solid concentration is 25%), 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous emulsion is made in homogeneous 3 times (every time 5 minutes).
G) obtained emulsion is spray-dried, EAT is 195 DEG C, leaving air temp is 80 DEG C.Collect powder Grease (powder fat).
2) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, add weight be raw material weight 4~6 times of 50~80% ethanol, soaked, extracted 2 times, conjunction And alcohol extract and it is concentrated into no alcohol taste；The active compound dregs of a decoction are flung to after ethanol, are added weight and are carried out for 6~8 times of water of raw material weight Immersion, carries out decocting 30~60min, filtering removes raw material, leaves and takes decoction liquor to soak；Merge the alcohol extract after concentration and decoct Boil liquid, and it is spray-dried, finally prepare integration of drinking and medicinal herbs component powders with 60~80 mesh sieves point；
3) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from oligomeric different malt Sugar carries out 2 emulsifying homogeneous processing under high pressure as wall material, and the emulsifying homogeneous time is 10~15min, then carries out spraying wink When dry, point prepare liposoluble vitamin powder with 60~80 mesh sieves；It regard the water soluble vitamin of predetermined weight number as core Material, from maltodextrin, oligoisomaltose as wall material, is well mixed, and spraying is instantaneous to be dried, and is prepared with 60~80 mesh sieves point Water soluble vitamin powder；
4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；(step 1) -4) order Can mutually it change)
5) by step 1)~step 4) obtained by powder sequentially add the mixers of cone-type mixer or other forms and mix Uniformly obtained formula mixture is closed, it is standby after sterilization processing；
6) according to conventional technical means by step 5) in formula mixture be prepared into nutrient powder, nutrition emulsion, capsule, At least one of tablet, pill or oral liquid.
In step 6) in, optionally increase appropriate food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, flavoring essence spices, brown sugar；More preferably carragheen, Arabic gum, Guar Glue, Aspartame, flavoring essence spices.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent production The danger of green powder blast.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 5
1) influence of nutrient formulation preparation prepared by the present invention to mouse weight；
The nutrient powder for taking the embodiment of the present invention 1~3 to prepare is tested, while setting comparative example 1, comparative example 2 and blank pair According to group, comparative example 1 uses embodiment 2 using nutrient powder prepared by oligopeptide, comparative example 2 is deleted in the nutrient formulation of embodiment 2 Nutrient formulation in delete nutrient powder prepared by integration of drinking and medicinal herbs composition, blank control group gavage physiological saline.
SPF grades of BALB/C mices, male and female half and half, body weight 28~35g, every group 10.Filled daily according to 0.3g/10g dosage Stomach mouse, continuous 30 days.Single cage is fed during to mouse stomach, and it is determined daily and takes in appetite, claims 1 body weight within every 3 days, finally Each group increased weight is calculated, 1 is shown in Table.
The nephrosis tailored version clinical nutrition of table 1 is formulated the influence to mouse weight
Group First body weight/g Whole body weight/g Weightening/g
Embodiment 1 28.3 45.4 17.1
Embodiment 2 28.4 47.1 18.7
Embodiment 3 29.8 46.7 16.9
Comparative example 1 31.2 47.8 16.6
Comparative example 2 29.0 45.1 16.1
Control group 31.9 45.8 13.9
Table 1 understands that the nutrient formulation has no to mouse weight growth and significantly affected, and can maintain the normal physiological work(of mouse Can, harmful effect is not produced to the normal growth of mouse.
2) therapeutic action of nutrient formulation preparation prepared by the present invention to STZ modeling adriamycin-induced nephropathy in Wistar rats；
The nutrient powder for taking the embodiment of the present invention 2 to prepare is tested, and sets Normal group, diabetic nephropathy model Group, Captopril group.
Using cleaning grade male SD rat 100, body weight is in 180-200g.With the intraperitoneal note of STZ citron acid solution buffer solutions Penetrate and prepare Diabetic nephropathy animal model, Normal group intraperitoneal injection equivalent citrate buffer.Inject after 72h, big rat-tail Vein surveys blood glucose>16.6mmol/L is modeling success, and animal is randomly divided into 5 groups, every group 10 by blood glucose value.
Each group experiment mice is raised, mouse freely ingests and drunk water in experimentation, it is continuous to feed 4 weeks.Leave and take 24h urines, next day femoral artery takes blood, separates serum, and blood, -20 DEG C of Urine specimens preserve standby survey.Rat renal is taken to weigh, on ice bath Cortex renis is taken, puts fixed in 10% formalin.
Test result indicates that the persistent high blood sugar nutrient powder group feeding that after 4 weeks prepared by Captopril group, the embodiment of the present invention 2 After 4 weeks in blood in Ure, blood Cr (SCr) and urine in mALB/Cr be substantially less than model control group；Test captopril after 4 weeks Nutrient powder group Pathological prepared by group, the embodiment of the present invention 2, which changes, is substantially lighter than diabetic model group.
Experimental result shows that nutrient formulation of the present invention can improve modeling animal renal function, albuminuria be reduced, to STZ The early nephropathy of induced diabetes nephrotic rats has significant preventive and therapeutic effect.
From above-described embodiment, various components are worked in coordination in the special clinical nutrition formula of nephrosis of the present invention, There is provided reasonable, comprehensive nutritional support for nephrotic, to improve the condition of nephrotic, while addition it is nourishing liver and kidney, Integration of drinking and medicinal herbs composition, natural plants compound and the new resource food of strengthening the essence blood-nourishing and strengthen immunity, delay progression of disease, carry High quality of life, extends the life-span.
The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and to replace In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and repaiied Change, all should be contained within the scope of the invention.

Claims (9)

1. a kind of nephrosis tailored version clinical nutrition formula, it is characterised in that including following component and its parts by weight：8-15 portions of eggs White matter, 8-12 parts of fat, 55-65 parts of carbohydrate, 3-5 parts of dietary fibers, 0.5-1.5 parts of macroelements, 0.01-0.04 parts Trace element, 0.005-0.015 parts of liposoluble vitamins, 0.01-0.2 parts of water soluble vitamins, 0.05-1 parts of meals elite, 0.05-2 parts of integration of drinking and medicinal herbs compositions, 0.1-3 parts of natural plants compounds and 0.005-2 parts of new resource foods；
Wherein, the integration of drinking and medicinal herbs composition is selected from Fermented Soybean, Poria cocos, raspberry, matrimony vine, sealwort, balloonflower root, Gorgon fruit, Chinese yam, oyster At least one of；
Wherein, the protein includes the small protein that mean molecule quantity is below 1000D.
2. a kind of nephrosis tailored version clinical nutrition formula according to claim 1, it is characterised in that the small molecular protein Matter is of animal or plant nature oligopeptide, and its parts by weight is 0-1 parts, and it includes soybean oligopeptide and ocean fish oligopeptide.
3. a kind of nephrosis tailored version clinical nutrition formula according to claim 1, it is characterised in that the integration of drinking and medicinal herbs into The parts by weight of each component are as follows in point：0~1 part of Fermented Soybean, 0~1 part of Poria cocos, 0~1 part of raspberry, 0~1 part of matrimony vine, sealwort 0~1 part, 0~1 part of balloonflower root, 0~1 part of Gorgon fruit, 0~1 part of Chinese yam, 0~1 part of oyster.
4. a kind of nephrosis tailored version clinical nutrition formula according to claim 1, it is characterised in that the dietary fiber is equal For water-soluble dietary fiber, it at least includes bag galactooligosaccharide and oligoisomaltose.
5. a kind of nephrosis tailored version clinical nutrition formula according to claim 1, it is characterised in that the fat contains purple 0-2 parts of perilla oil, 2-4 parts of medium chain triglyceride.
6. a kind of nephrosis tailored version clinical nutrition formula according to claim 1, it is characterised in that the natural plants Compound is selected from l-cn, Glucosamine, FOS, lutein, phytosterol, lycopene, resveratrol, allicin At least one of.
7. a kind of nephrosis tailored version clinical nutrition formula according to claim 1, it is characterised in that the new resource food Gather selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, CPP, oat β-Portugal At least one of sugar, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii, xylo-oligosaccharide.
8. a kind of preparation method of nephrosis tailored version clinical nutrition formula as claimed in claim 1, it is characterised in that including such as Lower step：
(1) fat of predetermined weight, liposoluble vitamin, water soluble vitamin are respectively adopted micro-capsule embedding techniques and prepare and cross 60 Powder is made in~80 mesh sieves；
(2) the integration of drinking and medicinal herbs composition of predetermined weight is by crushing, alcohol extracting, water extraction, spray drying and powder is made in 60-80 mesh sieves excessively End；
(3) remaining component of predetermined weight is prepared into the powder that particle diameter is 150~250 μm respectively；
(4) be mixed can direct pharmaceutical formulation for the powder for preparing step (1)-(3)；
Wherein, the order of step (1)-(3) can be changed mutually；The pharmaceutical formulation include nutrient powder, nutrition emulsion, capsule, Tablet, pill, oral liquid.
9. the preparation method of nephrosis tailored version clinical nutrition formula according to claim 8, it is characterised in that step (2) The preparation method of integration of drinking and medicinal herbs component powders is as follows：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, add weight be raw material weight 4~6 times of 50~80% ethanol, soaked, extracted 2 times, conjunction And alcohol extract and it is concentrated into no alcohol taste；The active compound dregs of a decoction are flung to after ethanol, are added weight and are carried out for 6~8 times of water of raw material weight Immersion, carries out decocting 30~60min, filtering removes raw material, leaves and takes decoction liquor to soak；Merge the alcohol extract after concentration and decoct Boil liquid, and it is spray-dried, finally prepare integration of drinking and medicinal herbs component powders with 60~80 mesh sieves point.
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CN108651988A (en) * 2018-05-10 2018-10-16 上海奥医生物医药科技有限公司 Nephrosis dialysis tailored version clinical nutrition formula and preparation method thereof
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CN115054677A (en) * 2022-03-24 2022-09-16 大医声科技(北京)有限公司 Multi-vitamin nutrient formula suitable for patients with nephropathy
CN115137059A (en) * 2022-05-23 2022-10-04 青岛普瑞森医药科技有限公司 Non-full-nutrition food for improving nephropathy and preparation process thereof

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