CN107440121A - A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof Download PDF

Info

Publication number
CN107440121A
CN107440121A CN201710731360.2A CN201710731360A CN107440121A CN 107440121 A CN107440121 A CN 107440121A CN 201710731360 A CN201710731360 A CN 201710731360A CN 107440121 A CN107440121 A CN 107440121A
Authority
CN
China
Prior art keywords
powder
vitamin
parts
clinical nutrition
tailored version
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710731360.2A
Other languages
Chinese (zh)
Inventor
尤俊
季敬东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Olympic Medical Biotechnology Co Ltd
Original Assignee
Shanghai Olympic Medical Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Olympic Medical Biotechnology Co Ltd filed Critical Shanghai Olympic Medical Biotechnology Co Ltd
Priority to CN201710731360.2A priority Critical patent/CN107440121A/en
Publication of CN107440121A publication Critical patent/CN107440121A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/22—Comminuted fibrous parts of plants, e.g. bagasse or pulp
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a kind of Single Obesity tailored version clinical nutrition formula, and it includes following component and its parts by weight：Protein, fat, carbohydrate, water-soluble dietary fiber, macroelement, trace element, liposoluble vitamin, water soluble vitamin, meals elite, integration of drinking and medicinal herbs composition, natural plants compound and new resource food；The invention further relates to the preparation method of above-mentioned clinical nutrition formula, powder is made in its each component in advance, and powder is made using alcohol extracting water extraction concentration, spray drying in integration of drinking and medicinal herbs composition, and vitamin and fat are handled by microencapsulation is made powder；Or powder is made to each component progress emulsifying homogeneous, spray drying by wet processing.Screening and proportioning by said components, nutrient formulation of the present invention provides the nutritional support of comprehensive abundance for simple obese children, to improve the condition of simple obese children patient, plays the taste ability for improving children, loses weight, build up health.

Description

A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food field, and in particular to a kind of Single Obesity tailored version faces Bed nutrient formulation and preparation method thereof.
Background technology
Simple obesity refers to exclude as the Secondary cases caused by metabolic disease, wound or Other diseases, pathologic fertilizer It is fat, and the systemic fat caused by energy surplus is built up merely.Being continuously increased for obesity in childhood turns into complete The public health problem that ball is gazed at.Obesity is the complicated illness influenceed by genetic behavior and environment.With expanding economy and people Living-pattern preservation, environment and behavial factor obesity morbidity in play more and more important effect.Obesity in Childhood is Energetic supersession caused by multifactor is unbalance.With the development of food industry, purified diet, frying and phitosite change significantly The eating pattern of people, the generation grown up in such a case receive unavoidably " three high and one low " (high heat, it is higher fatty acid, High protein and low dietary fiber) uneven diet.The social factor of another significant is the sprawling of fast food culture.Cross These fast foods are eaten more, can be made nutrient imbalance, be caused obesity.What is easily ignored is Psychological and Behavioral Factors, Psychology and behavior Factor refers to feeds under non-starvation, shows as some children and sees that food is just wanted to eat, some children are liked when seeing TV Feed, what is also had must eat could fall asleep just before going to bed.These influent pHs are not in order at the needs of body, but a kind of Custom, it is superfluous as the nutrition intake caused by abnormal psychological factor.
Single Obesity is to work as previous important children's health problem, and some areas are increased by the 3% of the eighties To the 10% of the nineties, the annual average rate of increase highest of southern area Single Obesity, reach 17.5%.Guangdong Province Some regional pupil's simple obesity incidences are up to 12.1%.Simple obesity can cause children's body some organs, be Functional, mobility and the constitution of uniting are horizontal to be declined, while also infantile psychology can be caused necessarily to influence.At children In a special growth and development stage, obesity not only causes serious threat, or manhood obesity, glycosuria to children's health A kind of pathogenetic important risk factor of the diseases such as disease, atherosclerosis, it has also become common disease of serious threat children's health.Draw Rise children obesity the reason for be it is many, wherein diet intake it is unreasonable be probably children obesity occur an important original Cause.
Obese children has that various food intakes are more, the intake of meals Macronutrient is big, breakfast, lunch, dinner The characteristics of Energy intaking amount is more.Obese children is heavy, and intestinal absorption rate increase, the nutrition of quick absorbed into serum is deposited in the form of fatty In internal, while Obese children is more with insulin resistance and hyperinsulinemia.Such vicious circle, cause a fat and system Row pathophysiological change, severe patient cause hyperlipidemia, fatty liver etc..
Largely occur that weight is decreased obviously after the short-term drug therapy of simple obesity, but there is weight after drug withdrawal A certain degree of bounce-back, moreover, drug therapy there are many adverse reactions, it is not particularly well suited for children and adolescents.And non-drug is comprehensive It is the basis for treating Simple Obesity in Children to close remedy measures, including improves diet structure, exercising with oxygen, changes lifestyles With transition of people's conceptions etc..Purpose is to make fat youngster's weight close to perfect condition, while its health and growth can not be sent out again Educate and impact.At present, to the treatment of Single Obesity, Western medicine is convenient to take, but mostly there is side effect, can be to children Grow and produce harmful effect；Chinese medicine side effect is smaller, and cost is cheap, but needs suitable long-term use of.
Therefore, while development can provide the basal nutrient element needed for simple obese children, it is single that and can improves children The product of pure property obese state has important value and wide market.
The content of the invention
The defects of it is an object of the invention to overcome in the prior art, there is provided a kind of Single Obesity tailored version is clinical Nutrient formulation and preparation method thereof, its adjustment simple obese children, which is often eaten, takes in energy proportion and quantity, increases dietary fiber, The trace element and high-quality protein needed for child growth are supplemented simultaneously, improves Single Obesity state, are lost weight, enhancing Constitution.Nutrient refers in food to human body provides energy, participation body forms and the chemical composition of regulation of physiological functions.Human body Necessary nutrition is known as protein, lipid, carbohydrate, mineral matter, vitamin, water, dietary fiber etc..Respectively eaten energy point in whole day In matching somebody with somebody, Obese children breakfast, lunch, the energy of dinner intake are all remarkably higher than non-obese children.Expert recommends, children's breakfast, lunch and dinner energy Amount is assigned as breakfast 25%, lunch 35%, dinner 30%, tiffin 10%, morning of children in the present invention, the noon, dinner energy supply ratio with The ratio that expert recommends approaches.
To achieve the above object, the present invention adopts the following technical scheme that：
First purpose of the present invention is to provide a kind of Single Obesity tailored version clinical nutrition formula, including as follows Component and its parts by weight：15~22 parts of protein, 3~8 parts of fat, 45-60 parts carbohydrate, 7.8-10.5 part meals Fiber, 0.6-1.5 parts macroelement, 0.01-0.04 parts trace element, 0.01-0.03 parts liposoluble vitamin, 0.01-0.2 parts Water soluble vitamin, 0.1-2 part meals elite, 0.4-3 part integration of drinking and medicinal herbs composition, 0.1-3 part natural plants compounds and 0.005-2 part new resource foods.
In order to further optimize above-mentioned clinical nutrition formula, the technical measures that the present invention is taken also include：
Preferably, in above-mentioned nutrient formulation, protein, fat, the productivity ratio of carbohydrate are 18~24：9~ 13：60~70；It is highly preferred that the productivity ratio of protein, fat, carbohydrate is 20：11：69.
Preferably, the protein be selected from PURE WHEY, soybean protein isolate, hydrolysis Isin glue collagen, whole milk powder, At least one of dried whole-egg, lactoferrin, colostrum, amino acid, protein peptides；Wherein protein content is in whole milk powder 24wt%, fat content 34wt%, carbohydrate content 40wt%.
Wherein, the amino acid is selected from 1B-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, ILE, L-Leu；The protein peptides are selected from soy oligosaccharides At least one of peptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide, laughable peptide, amino peptide, ovalbumin peptide.
It is highly preferred that the protein includes PURE WHEY, soybean protein isolate, whole milk powder, colostrum, ox sulphur Acid, ocean fish oligopeptide.
Preferably, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structures At least one of fat, DHA, EPA, ARA, phosphatide, more specifically described fat include safflower seed oil, walnut oil, peanut oil, Soybean oil, Ah's glycerine, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, deep sea fish oil, cupu oil, palm Oil, butter, cream, lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil etc.；More preferably olive oil, soybean oil, coconut Oil, perilla herb oil, medium chain triglyceride.
Preferably, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch, jade At least two in rice starch；More preferably rock sugar, maltodextrin.
Preferably, the dietary fiber include inulin, konjaku flour, galactooligosaccharide, FOS, oligoisomaltose, At least one of soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；It is highly preferred that the dietary fiber includes 7-9 parts Water-soluble dietary fiber and 0.8-1.5 part insoluble diedairy fibers, it contains konjaku flour.
Preferably, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, sodium citrate At least one of with magnesium gluconate.
Preferably, the trace element is selected from ferrous gluconate, KI, zinc gluconate, sodium selenite, glucose At least one of sour copper, chromium sulfate, manganese gluconate and sodium molybdate.
Preferably, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, vitamin K1 At least one of.
Preferably, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, at least one of pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin.
Preferably, the meals elite is selected from cereal, beans, potato class, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；The cereal is selected from rice meal, millet powder, black rice flour, coixlacrymajobi powder, corn At least one of powder, wheat germ powder, oatmeal, buckwheat；The beans is selected from peameal, mung bean flour, black bean powder, red bean Powder, soy meal, at least one of navy bean powder；The potato class is mainly made up of common yam rhizome powder；The Vegetable powder be selected from carrot meal, At least one of white radish powder, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae is selected from mushroom At least one of powder, Kelp Powder and white fungus powder；The nut-seed class is selected from least one of pumpkin seed powder and lotus nut starch； The fish and shrimp are selected from least one of salmon powder and cod meal；The poultry meat is selected from chicken meal, powdered beef and pig At least one of kidney powder；The fruits are in red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder It is at least one；More preferably oatmeal, navy bean powder, powdered beef, green tea powder, the parts by weight of kiwi fruit powder, wherein navy bean powder Number is 0.01~0.5 part.
Preferably, the natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, plant At least one of sterol, lycopene, resveratrol, allicin；More preferably l-cn.
Preferably, the integration of drinking and medicinal herbs composition is selected from Poria cocos, lotus leaf, peppermint, radix glycyrrhizae, balloonflower root, orange peel, pawpaw, galangal At least one of.
It is highly preferred that the parts by weight of each component are as follows in the integration of drinking and medicinal herbs composition：0~1 part of lotus leaf, peppermint 0~1 Part, 0~1 part of radix glycyrrhizae, 0~1 part of balloonflower root, 0~1 part of orange peel, 0~1 part of pawpaw, 0~1 part of galangal.
Preferably, the new resource food is selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo Leaf flavones, CPP, avenabeta glucosan, Oligomeric manna sugar, Rosa roxburghii, yeast beta-dextran, newborn mineral salt, maca At least one of powder, barley seedling, xylo-oligosaccharide；It is highly preferred that the new resource food is barley seedling and avenabeta glucosan.
Second object of the present invention is to provide a kind of system of above-mentioned Single Obesity tailored version clinical nutrition formula Preparation Method method, it comprises the following steps：
Step 1) prepares liposoluble vitamin powder and water soluble vitamin powder using micro-capsule embedding techniques；
Step 2) prepares integration of drinking and medicinal herbs component powders using crushing, alcohol extracting, water extraction, spray drying and sifting step；
Step 3) is smart by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals China, natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively, if desired Above-mentioned raw materials can be carried out in advance baking processing；
Step 4) is by step 1) -3) sterilize after the powder for preparing is well mixed it is standby；
Mixed-powder in step 4) is prepared into nutrient powder, nutrition emulsion, capsule by step 5) according to conventional technical means At least one of agent, tablet, pill or oral liquid；
Wherein, step 1) -3) order can mutually change.
Third object of the present invention is to provide one kind by above-mentioned Single Obesity tailored version clinical nutrition formula system Standby product, including nutrient powder, nutrition emulsion, capsule, tablet, pill, oral liquid etc..
In above-mentioned preparation method, wherein, the raw material of the integration of drinking and medicinal herbs composition is crushed, alcohol extracting concentration, water extraction are dense Contracting, and concentrate is subjected to spray drying integration of drinking and medicinal herbs component powders are made；Wherein, the vitamin and fat are respectively by micro- Encapsulated processing is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows：Using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, adds 3~5 times of 60~80% second that weight is raw material weight Alcohol, soaked, extracted 2 times, merged alcohol extract and be concentrated into no alcohol taste；After the active compound dregs of a decoction fling to ethanol, weight is added as original 6~8 times of water of material weight is soaked, and is carried out 30~60min of decoction to soak, is filtered off except raw material, leaves and takes decoction Liquid；Merge alcohol extract and decoction liquor after concentration, and it is spray-dried, it is same finally to prepare medicine food with 60~80 mesh sieves point Derived components powder.
Preferably, what the microencapsulation of the vitamin was handled comprises the following steps that：1) using liposoluble vitamin as core Material, from sodium carboxymethylcellulose, gelatin, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One or more in powder, emulsifying agent, stabilizer high-pressure homogeneous emulsification, are sprayed instantaneous dry, with 60~80 mesh sieves as wall material Divide and prepare liposoluble vitamin powder；2) using water soluble vitamin as core, from sodium carboxymethylcellulose, gelatin, OK a karaoke club Glue, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum One or more works in powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer For wall material, it is well mixed, sprays instantaneous dry, water soluble vitamin powder is prepared with 60~80 mesh sieves point.
Preferably, if this formula adds appropriate fat, the fat is prepared into powder using micro-capsule embedding techniques, Its specific implementation step is as follows：Fat, emulsifying agent, wall material and water mixed dissolution are prepared into emulsion；Above-mentioned emulsion is stirred After mixing, emulsifying homogeneous processing is carried out, is then spray-dried, screening prepares fat powder, fat powder and conventional grease Compare, its dispersiveness, water solubility, emulsibility, inoxidizability all improve a lot；Wherein, the emulsifying agent is selected from glycerin fatty Acid esters (glyceride), methyl glycol fatty acid ester (propylene glycol ester), sorbitan aliphatic ester (sorbitan acid), sucrose-fatty One or more in ester (sucrose ester), lecithin, monoglyceride, Tween 80；The wall material is selected from sodium carboxymethylcellulose, bright Glue, carragheen, xanthans, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, meals One kind in fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifying agent, stabilizer It is or a variety of.
In above-mentioned nutrient formulation, 1~3 part of sea mustard powder, 1~3 part of laver powder, 1~3 part of Kelp Powder, shrimp can be also set up 1~3 part of skin powder, more fully to supplement related nutritional element, undaria pinnitafida, seaweed, kelp Rich contain vitamin and dietary fiber, had concurrently There is the effect of anti-oxidant, to build up health, dried small shrimp contains abundant iron, calcium, P elements.
Fourth object of the present invention is to provide a kind of system of above-mentioned Single Obesity tailored version clinical nutrition formula Preparation Method, it is wet processing, is comprised the following steps：
Step 1) prepares the protein containing predetermined weight number, carbohydrate, dietary fiber, macroelement, micro Element, vitamin, integration of drinking and medicinal herbs composition, the raw material of natural plants compound and new resource food, in the water of scheduled volume, According to the physical behavior of raw material, added successively according to sequencing, be stirred while addition, the mixing of raw material is made Emulsion；
The temperature for the mixed emulsion that step 2) obtains step 1) is maintained at 40-50 DEG C, and adjustment homogenization pressure makes it all the time It is maintained between 10-18Mpa, emulsifying homogeneous is carried out to mixed emulsion, then placed emulsion in evaporator, with default skill Art parameter is concentrated, and is sterilized at 85-88 DEG C, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), is crossed 60~80 mesh sieves, is prepared into powder；Using upper State powder and be prepared at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
Being used in the present invention includes the integration of drinking and medicinal herbs composition of lotus leaf, peppermint, radix glycyrrhizae, balloonflower root, orange peel, pawpaw, galangal, on There is the effect of cleansing stomach, dispelling the phlegm wet of big enteral, damp and hot and conditioning viscera after stating components compatibility synergy, can effectively change Organism physiology, biochemistry and the immunologic function of kind simple obese children patient.
Chemical analysis in lotus leaf mainly has Nuciferine, citric acid, malic acid, gluconic acid, oxalic acid, butanedioic acid and other The alkali components of antimitotic effect.The lotus leaf alkaloid extracted in lotus leaf coarse powder can suppress pancreatic lipase, subtract so as to play The effect of weight.
Peppermint energy stimulating central nervous system, surrounding capillaries are made to expand and radiate；And promote sweat gland secretion and sweating.Peppermint Oil has obvious choleretic effect, and can slightly increase the discharge rate of bile acid in bile.
Platycodin and celery sugar platycodin is gone all to show significant inhibitory action to pancreatic lipase in balloonflower root, wherein Platycodin D effect is more notable, and Platycodin D is probably main anti-obesic action composition, and it can raise 3T3-L1 fat Upstream like factor 2 (krupple-likeFactor2, KLF-2) expression of cell, then lower and Fatty synthesis enzyme activition Related peroxisome proliferators activated receptor γ is horizontal, significantly inhibits the accumulation of the acid esters of intracellular three, lowers fat The expression of the gene relevant with fat metabolism such as fat acid binding protein 4, lipoprotein lipase, so as to play anti-obesic action.
Orange peel has conditioning digestive system, strengthens functions of intestines and stomach, and cholagogic is aid digestion, reduces, is digested not for insufficiency of the spleen diet It is good, and nausea and vomiting etc..Orange peel can promote the secretion of digestive juice, exclude enteral pneumatosis.Intestines caused by anti-acetylcholine are received Contracting.Also can intestinal tube spasmodic contraction caused by antagonism pilocarpinum and barium chloride.Shorten the Migrating Myoelectric Complex week of small intestine Phase, improve the digestive function of small intestine.Active ingredient-aurantiamarin has excitation to stomach smooth muscle, can substantially antagonism Ah Gastric emptying and small intestine push inhibitory action caused by tropine, adrenaline.Hesperidin methyl substantially Inhibition test stomach can burst The generation of ulcer, and the effect of also anti-gastric acid secretion；Hesperidin methyl can make rat gallbladder contraction, solid in bile and bile The excretion increase of material, uses VC and VK4 if merging, can strengthen cholagogic effect.
Pawpaw has mitigation necrosis of liver cells, mitigates liver cell fatty degeneration, prevents swelling of liver cell, balloon sample from becoming, and promotes liver thin Born of the same parents' repair, also significantly reduce in serum alanine aminotransferase effect pawpaw and contain substantial amounts of triterpenes platform thing, can be clear Except because degeneration of liver cells necrosis, organized enzyme inactivates in liver when body in caused by some toxin, make the activation recovering of fermentoid, promote Liver cell regeneration, so as to play hepatoprotective effect.
Galangal can make the total acid output of gastric juice significantly raised, but stomach cardia vigor is had no significant effect；Galangal decocting Agent has excitation to the motion of isolated rabbit intestinal tube；Galangal has inhibitory action to Bacillus tuberculosis；Galangal water extract or Volatile oil participates in intrinsic coagulation system, has certain anticoagulation, water extract can substantially suppress ADP or collagen-induced Rabbit platelet aggregation.
Compared with prior art, the invention has the advantages that：
(1) various nutrients are supplemented general equilibrium of the present invention, while adds to have and cleanses stomach, dispel the phlegm of big enteral The integration of drinking and medicinal herbs composition of the effect of wet, damp and hot and conditioning viscera, and effective drug effect is extracted using the method for water extraction alcohol extracting comprehensively Material, while helping children to improve fat Signs, the taste ability for improving children is played, loses weight, builds up health.
(2) three nutritious elements productivity ratio is in nutrient formulation of the present invention：Protein：Lipid：Carbohydrate=20： 11：69, fatty energy supply ratio accounts for 17% always energized, and low-fat content forces the fat depot of body consumption itself, reaches fat reducing Effect.
(3) l-cn that the present invention adds promotes aliphatic acid to carry out oxidation energy supply through mitochondrial membrane, promotees in motion Enter the burning of body fat to energize, while promote the oxidation of branched-chain amino acid to utilize, change the activity of mitochondria internal respiration enzyme, The ability of body aerobic oxidation energy supply is improved, the strong of immune system is kept, so as to avoid the invasion and attack of some diseases.
(4) present invention addition konjaku flour, konjaku flour main component is Glucomannan, containing abundant Soluble Fiber, without heat Amount, increase stomach satiety and intestinal contents volume are may expand, reduce the intake of fat and energy, promote enterocinesia.Pass through removing Fat and the endotoxic effect of enteric cavity, reach the purpose of fat-reducing.
(5) present invention adds navy bean extract, and the kidney bean albumen contained in navy bean is a kind of natural amylase suppression Preparation, confirm that alpha-amylase inhibitor plays fat-reducing effect by the inhibitory action to amylase according to clinical verification, and through stomach Enteron aisle excretes, therefore need not enter blood circulation system, does not act on brain centres, not appetite-suppressing while fat-reducing, And it contains abundant dietary fiber, increase satiety, so as to have the function that fat-reducing.
(6) present invention prepares vitamin using micro-capsule embedding techniques, and vitamin is embedded in wall material, can prevent dimension from giving birth to Element is destroyed by macroelement, trace element, extends the holding time of vitamin；The present invention is prepared using micro-capsule embedding techniques Powdered oil so that powdered oil has preferable mobility, is easy to be well mixed with other powdered components；And use micro-capsule bag After burying technology, grease is embedded in wall material, so as to avoid the contact with air to strengthen inoxidizability, is protected so as to play The maximum effect of strong type grease.
(7) raw material of Single Obesity tailored version clinical nutrition formula of the present invention is pre- in preparation process 150~250 μm of powder is first prepared into, this make it that, when preparing finished product, each nutrition composition can be well mixed, guarantor unit's body The content of each nutrition composition in product is essentially identical, while when preparing liquid type preparation, each nutrition composition energy is fully dispersed simultaneously It is completely dissolved into solvent, prevents occurring solid precipitation in liquid, the effect of finished product product has been effectively ensured.
The present invention is by from rational basal nutrient element, using the proportioning of general equilibrium, while adding to have and cleansing intestines Stomach, dispel the phlegm wet of big enteral, damp and hot and conditioning viscera integration of drinking and medicinal herbs composition, natural plants compound, new resource food Deng specific nutrient, and adjust its proportioning and carry out compatibility synergy, the effect of giving full play to its component, so as to adjust with basal nutrient element Whole simple obese children, which is often eaten, takes in energy proportion and quantity, increases dietary fiber, improves simple obese children patient's Condition, play a part of prevention and treatment.
Embodiment
The present invention provides a kind of Single Obesity tailored version clinical nutrition formula, and it includes following component and its weight Number：15~22 parts of protein, 3~8 parts of fat, 45-60 parts carbohydrate, 7.8-10.5 parts dietary fiber, 0.6-1.5 parts Macroelement, 0.01-0.04 parts trace element, 0.01-0.03 parts liposoluble vitamin, 0.01-0.2 parts water soluble vitamin, 0.1-2 part meals elite, 0.4-3 part integration of drinking and medicinal herbs composition, 0.1-3 part natural plants compounds and 0.005-2 part new resources Food.In the formula, protein, fat, the productivity ratio of carbohydrate are 21：17：62；It is water-soluble that dietary fiber includes 7-9 parts Property dietary fiber and 0.8-1.5 part insoluble diedairy fibers.
With reference to embodiment, the embodiment of the present invention is further described.Following examples are only used for more Add and clearly demonstrate technical scheme, and can not be limited the scope of the invention with this.
Embodiment 1
Single Obesity tailored version clinical nutrition formula of the present invention includes PURE WHEY 10g, soybean point From albumen 5.33g, whole milk powder 20g, bovine colostrum 0.33g, taurine 0.12g, ocean fish oligopeptide 0.2g；Maltodextrin 34.6g, rock sugar 6.67g；Water-soluble dietary fiber 7g, insoluble diedairy fiber 1.07g；Calcium 0.44g, phosphorus in macroelement 0.27g, potassium 0.093g, sodium 0.143g, magnesium 0.16g；Iron 0.011g, zinc 0.008g in trace element；Vitamin A 0.0005g, Beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, vitamin B2 0.001g, vitamin B60.001g, vitamin B120.0000014g, vitamin C 0.103g, pantothenic acid 0.003g, folic acid 0.00013g, nicotinic acid 0.0121g；Oatmeal 0.67g, navy bean powder 0.33g, powdered beef 0.33g, green tea powder 0.07g, Kiwi berry Powder 0.33g, peppermint 0.33g, radix glycyrrhizae 0.4g, lotus leaf 0.33g, balloonflower root 0.33g, pawpaw 0.33g, galangal 0.33g, orange peel 0.33g, barley seedling 0.33g, avenabeta glucosan 0.33g, l-cn 1g.
Embodiment 2
Single Obesity tailored version clinical nutrition formula of the present invention includes PURE WHEY 10g, soybean point From albumen 5.33g, whole milk powder 20g, bovine colostrum 0.33g, taurine 0.12g, ocean fish oligopeptide 0.2g；Maltodextrin 34.6g, rock sugar 6.67g；Water-soluble dietary fiber 7g, insoluble diedairy fiber 1.07g；Calcium 0.44g, phosphorus in macroelement 0.27g, potassium 0.093g, sodium 0.143g, magnesium 0.16g；Iron 0.011g, zinc 0.008g in trace element；Vitamin A 0.0005g, Beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, vitamin B2 0.001g, vitamin B60.001g, vitamin B120.0000014g, vitamin C 0.103g, pantothenic acid 0.003g, folic acid 0.00013g, nicotinic acid 0.0121g；Oatmeal 0.67g, navy bean powder 0.01g, powdered beef 0.33g, green tea powder 0.01g, Kiwi berry Powder 0.33g, peppermint 0.33g, radix glycyrrhizae 0.4g, lotus leaf 0.33g, balloonflower root 0.33g, pawpaw 0.33g, galangal 0.33g, orange peel 0.33g, barley seedling 0.01g, avenabeta glucosan 0.01g, l-cn 1g.
Embodiment 3
Single Obesity tailored version clinical nutrition formula of the present invention includes PURE WHEY 10g, soybean point From albumen 5.33g, whole milk powder 20g, bovine colostrum 0.33g, taurine 0.12g, ocean fish oligopeptide 0.2g；Maltodextrin 34.6g, rock sugar 6.67g；Water-soluble dietary fiber 7g, insoluble diedairy fiber 1.07g；Calcium 0.44g, phosphorus in macroelement 0.27g, potassium 0.093g, sodium 0.143g, magnesium 0.16g；Iron 0.011g, zinc 0.008g in trace element；Vitamin A 0.0005g, Beta carotene 0.017g, vitamin D30.000001g, vitamin E 0.009g；Vitamin B10.001g, vitamin B2 0.001g, vitamin B60.001g, vitamin B120.0000014g, vitamin C 0.103g, pantothenic acid 0.003g, folic acid 0.00013g, nicotinic acid 0.0121g；Oatmeal 0.67g, navy bean powder 0.01g, powdered beef 0.01g, green tea powder 0.01g, Kiwi berry Powder 0.01g, peppermint 0.1g, radix glycyrrhizae 0.1g, lotus leaf 0.1g, balloonflower root 0.1g, pawpaw 0.1g, galangal 0.1g, orange peel 0.1g, barley Seedling 0.01g, avenabeta glucosan 0.01g, l-cn 0.1g.
Embodiment 4
A kind of preparation method of the special clinical nutrition formula of Single Obesity as described in 1~embodiment of embodiment 3 It is as follows：
1) integration of drinking and medicinal herbs component powders are prepared：The raw material of predetermined weight number is crushed using pulverizer, will be crushed Raw material be placed in container, the raw material of predetermined weight number is crushed using pulverizer, the raw material of crushing is placed in container In, 3~5 times of 60~80% ethanol that weight is raw material weight are added, is soaked, extracted 2 times, merges alcohol extract and concentrates To without alcohol taste；After the active compound dregs of a decoction fling to ethanol, add weight and soaked for 6~8 times of water of raw material weight, soak is entered Row decocts 30~60min, filters off except raw material, leaves and takes decoction liquor；Merge alcohol extract and decoction liquor after concentration, and it is carried out Spray drying, finally prepare integration of drinking and medicinal herbs component powders with 60~80 mesh sieves point；
2) vitamin powder is prepared：Using the liposoluble vitamin of predetermined weight number as core, from oligomeric different malt Sugar is used as wall material, carries out 2 emulsifying homogeneous processing under high pressure, the emulsifying homogeneous time is 10~15min, then carries out spraying wink When dry, point prepare liposoluble vitamin powder with 60~80 mesh sieves；Using the water soluble vitamin of predetermined weight number as core Material, from maltodextrin, oligoisomaltose as wall material, it is well mixed, sprays instantaneous dry, prepared with 60~80 mesh sieves point Water soluble vitamin powder；
3) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, trace element, meals elite, Natural plants compound and new resource food are prepared into the powder that particle diameter is 150~250 μm respectively；(step 1) -3) order Can mutually it change)
4) by step 1) -3) prepare powder in the similar devices such as mixer be well mixed after sterilize it is standby；
5) mixed-powder obtained by step 4) is prepared into nutrient powder, nutrition emulsion, capsule according to conventional technical means At least one of agent, tablet, pill or oral liquid.
In step 5), optionally increase appropriate food thickening agent, food additives and related formulation auxiliary material. The food thickening agent is in guar gum, xanthans, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one, the food additives are Aspartame, flavoring essence spices, at least one of brown sugar；More preferably OK a karaoke club Glue, Arabic gum, guar gum, Aspartame, flavoring essence spices.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder blast.
According to described with the classifications such as powdery, graininess, capsule shape, tablet shape, beverage can be prepared into.
Embodiment 5
1) influence of nutrient formulation preparation prepared by the present invention to normal mouse；
First, acute toxicity test；
The nutrient powder prepared with the embodiment of the present invention 2,1 group of little Bai is given with 150 times of clinical consumption per day and 200 times respectively Mouse feeding is offerd medicine, and is observed 14；As a result all small white mouses are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no Toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other adverse reactions.
2nd, long term toxicity test；
Nutrition powder prepared by the embodiment of the present invention 1 is dissolved in water to mouse by 3,10 and 24g nutrient powders/kg, to 3 Group mouse difference continuous use 12 weeks, 2 times a day, and after drug withdrawal 4 weeks, the results showed that：Chinese medicine of the present invention is to two groups of test mices Hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood glucose, the index such as blood fat have no significant effect, it is dirty Device naked eyes are without finding that difference change and histological indications show, after medication 12 weeks and drug withdrawal 4 weeks, the equal nothing of Organs of Mice It is obvious to change.Illustrate that nutrient formulation preparation of the present invention to small toxicity after mouse long-term prescription, does not have abnormal reaction yet, answered after drug withdrawal With safety.
2) therapeutic effect of nutrient formulation preparation prepared by the present invention to simple obese children patient；
In order to verify the effect of nutrient formulation preparation of the present invention, we have extracted 200 simple obese children patients and entered Go experiment, be equally divided into two groups, experimental group and control group, the data difference such as two groups of sexes, age, courses of disease there are no significant meaning Combine and carry out with low caloric diet and motion when justice, there is comparativity, and treating.
Experimental group：Take with the nutrient powder prepared in the embodiment of the present invention 2,2 times a day, 1 100mg.
Control group：Oral orlistat capsule, one time a day.1 time 1.
Curative effect situation criterion：1 height, body weight are measured weekly, calculate body mass index：Body mass index=body weight (kg) ÷ [height (m)]2, and observe main related symptoms and sign.Cure：Body mass index is down to normally, and symptom and sign disappears；It is aobvious Effect：Body mass index is down to 19-24, and symptom and sign largely disappears；Effectively：Body mass index is declined slightly, and symptom and sign part changes It is kind；It is invalid：Body mass index, symptom and sign is without improvement.
Its experimental result such as following table：
As seen from the above table, control group and experimental group are effective in cure to treatment simple obesity, but nutrition prepared by the present invention The effect of formula, is better than control group.
From above-described embodiment, various components in the special clinical nutrition formula of Single Obesity of the present invention Work in coordination, reasonable, comprehensive nutritional support is provided for simple obese children disease patient, to improve simple obese children trouble The condition of person, while add with addition with stomach is cleansed, the phlegm wet of big enteral, damp and hot and conditioning viscera are dispelled, Playing improves the taste ability of children, loses weight, builds up health.
The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and to replace In generation, is also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and repair Change, all should be contained within the scope of the invention.

Claims (9)

1. a kind of Single Obesity tailored version clinical nutrition formula, it is characterised in that including following component and its parts by weight Number：15~22 parts of protein, 3~8 parts of fat, 45-60 parts carbohydrate, 7.8-10.5 parts dietary fiber, 0.6-1.5 parts are normal Secondary element, 0.01-0.04 parts trace element, 0.01-0.03 parts liposoluble vitamin, 0.01-0.2 parts water soluble vitamin, 0.1-2 part meals elite, 0.4-3 part integration of drinking and medicinal herbs composition, 0.1-3 part natural plants compounds and 0.005-2 part new resources Food；
Wherein, the integration of drinking and medicinal herbs composition in Poria cocos, lotus leaf, peppermint, radix glycyrrhizae, balloonflower root, orange peel, pawpaw, galangal extremely Few one kind；
Wherein, in the dietary fiber, 7-9 parts water-soluble dietary fiber and 0.8-1.5 part insoluble diedairy fibers are contained.
Wherein, protein, fat, the productivity ratio of carbohydrate are 18~24：9~13：60~70.
2. a kind of Single Obesity tailored version clinical nutrition formula according to claim 1, it is characterised in that described Integration of drinking and medicinal herbs composition is lotus leaf, peppermint, radix glycyrrhizae, balloonflower root, orange peel, pawpaw, galangal.
3. a kind of Single Obesity tailored version clinical nutrition formula according to claim 2, it is characterised in that described The parts by weight of integration of drinking and medicinal herbs composition are as follows：0~1 part of lotus leaf, 0~1 part of peppermint, 0~1 part of radix glycyrrhizae, 0~1 part of balloonflower root, orange peel 0 ~1 part, 0~1 part of pawpaw, 0~1 part of galangal.
4. a kind of Single Obesity tailored version clinical nutrition formula according to claim 1, it is characterised in that described Contain navy bean powder in meals elite, its parts by weight is 0.01~0.5 part.
5. a kind of Single Obesity tailored version clinical nutrition formula according to claim 1, it is characterised in that described New resource food be selected from first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, CPP, Avenabeta glucosan, Oligomeric manna sugar, Rosa roxburghii, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii, barley seedling, oligomeric wood At least one of sugar.
6. a kind of Single Obesity tailored version clinical nutrition formula according to claim 5, it is characterised in that described New resource food is barley seedling and avenabeta glucosan.
7. a kind of Single Obesity tailored version clinical nutrition formula according to claim 1, it is characterised in that described Natural plants compound is selected from l-cn, Glucosamine, FOS, lutein, phytosterol, lycopene, white lamb's-quarters At least one of reed alcohol, allicin.
8. a kind of preparation method of Single Obesity tailored version clinical nutrition formula as claimed in claim 1, its feature It is, comprises the following steps：
The liposoluble vitamin, water soluble vitamin of step (1) predetermined weight are respectively adopted micro-capsule embedding techniques and prepare and cross 60 Powder is made in~80 mesh sieves；
The integration of drinking and medicinal herbs composition of step (2) predetermined weight is made up of crushing, alcohol extracting, water extraction, spray drying and 60-80 mesh sieves excessively Powder；
Remaining component of step (3) predetermined weight is prepared into the powder that particle diameter is 150~250 μm respectively；
The powder that step (4) prepares step (1)~(3) is sterilized standby after being well mixed；
Direct-edible pharmaceutical formulation is made in step (4) mixed powder by step (5)；
Wherein, the order of step (1)~(3) can be changed mutually；The pharmaceutical formulation include nutrient powder, nutrition emulsion, capsule, Tablet, pill, oral liquid.
9. the preparation method of Single Obesity tailored version clinical nutrition formula according to claim 1, its feature exist In comprising the following steps：
Step 1) prepare the protein containing predetermined weight number, carbohydrate, dietary fiber, macroelement, trace element, Vitamin, integration of drinking and medicinal herbs composition, the raw material powder of natural plants compound and new resource food, in the water of scheduled volume, According to the physical behavior of raw material, added successively according to sequencing, be stirred while addition, the mixing of raw material is made Emulsion；
The mixed emulsion that step 2) obtains step 1) carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), sieving, is prepared into powder, and above-mentioned powder is prepared into At least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral liquid.
CN201710731360.2A 2017-08-23 2017-08-23 A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof Pending CN107440121A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710731360.2A CN107440121A (en) 2017-08-23 2017-08-23 A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710731360.2A CN107440121A (en) 2017-08-23 2017-08-23 A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof

Publications (1)

Publication Number Publication Date
CN107440121A true CN107440121A (en) 2017-12-08

Family

ID=60493864

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710731360.2A Pending CN107440121A (en) 2017-08-23 2017-08-23 A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof

Country Status (1)

Country Link
CN (1) CN107440121A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108077911A (en) * 2017-12-13 2018-05-29 上海奥医生物医药科技有限公司 A kind of epileptic's tailored version clinical nutrition formula and preparation method thereof
CN108902326A (en) * 2018-07-23 2018-11-30 东北农业大学 A kind of novel soybean milk powder formula
CN109077230A (en) * 2018-09-06 2018-12-25 赵国庆 A kind of functionality meal replacing food and application
CN110574862A (en) * 2018-06-11 2019-12-17 江苏帝尔生物科技有限公司 Nutritional weight-losing meal replacement powder suitable for teenagers and children and preparation method thereof
WO2022073653A1 (en) * 2020-10-08 2022-04-14 Unilever Ip Holdings B.V. A zinc fortified tea composition
EP4000405A1 (en) * 2020-11-20 2022-05-25 Unilever IP Holdings B.V. A zinc fortified tea composition
CN114916600A (en) * 2022-05-19 2022-08-19 陈杰 Functional white kidney bean beverage and preparation method thereof

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106490605A (en) * 2016-12-23 2017-03-15 上海奥医生物医药科技有限公司 A kind of hypertension of pregnancy tailored version clinical nutrition formula and preparation method thereof
CN106579393A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrient formula for diabetes and preparation method thereof
CN106578093A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Wound, infection, operation and other stress state special-purpose clinical nutrition formula and preparation method thereof
CN106579460A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrition formula for fracture and preparation method thereof
CN106616615A (en) * 2016-12-23 2017-05-10 上海奥医生物医药科技有限公司 Clinical nutrient formula special for tumor and preparation method of clinical nutrient formula
CN106666728A (en) * 2016-12-23 2017-05-17 上海奥医生物医药科技有限公司 Special clinical nutrient composition for gestational diabetes and preparation method of nutrient composition
CN106858595A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 One kind burn tailored version clinical nutrition formula and preparation method thereof
CN106858620A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106942748A (en) * 2017-03-29 2017-07-14 上海奥医生物医药科技有限公司 A kind of female acyesis tailored version clinical nutrition formula and preparation method thereof
CN106962912A (en) * 2017-03-29 2017-07-21 上海奥医生物医药科技有限公司 A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN106983151A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN106983136A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106490605A (en) * 2016-12-23 2017-03-15 上海奥医生物医药科技有限公司 A kind of hypertension of pregnancy tailored version clinical nutrition formula and preparation method thereof
CN106579393A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrient formula for diabetes and preparation method thereof
CN106578093A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Wound, infection, operation and other stress state special-purpose clinical nutrition formula and preparation method thereof
CN106579460A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrition formula for fracture and preparation method thereof
CN106616615A (en) * 2016-12-23 2017-05-10 上海奥医生物医药科技有限公司 Clinical nutrient formula special for tumor and preparation method of clinical nutrient formula
CN106666728A (en) * 2016-12-23 2017-05-17 上海奥医生物医药科技有限公司 Special clinical nutrient composition for gestational diabetes and preparation method of nutrient composition
CN106858595A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 One kind burn tailored version clinical nutrition formula and preparation method thereof
CN106858620A (en) * 2017-03-29 2017-06-20 上海奥医生物医药科技有限公司 A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106942748A (en) * 2017-03-29 2017-07-14 上海奥医生物医药科技有限公司 A kind of female acyesis tailored version clinical nutrition formula and preparation method thereof
CN106962912A (en) * 2017-03-29 2017-07-21 上海奥医生物医药科技有限公司 A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN106983151A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN106983136A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108077911A (en) * 2017-12-13 2018-05-29 上海奥医生物医药科技有限公司 A kind of epileptic's tailored version clinical nutrition formula and preparation method thereof
CN110574862A (en) * 2018-06-11 2019-12-17 江苏帝尔生物科技有限公司 Nutritional weight-losing meal replacement powder suitable for teenagers and children and preparation method thereof
CN108902326A (en) * 2018-07-23 2018-11-30 东北农业大学 A kind of novel soybean milk powder formula
CN109077230A (en) * 2018-09-06 2018-12-25 赵国庆 A kind of functionality meal replacing food and application
WO2022073653A1 (en) * 2020-10-08 2022-04-14 Unilever Ip Holdings B.V. A zinc fortified tea composition
EP4000405A1 (en) * 2020-11-20 2022-05-25 Unilever IP Holdings B.V. A zinc fortified tea composition
CN114916600A (en) * 2022-05-19 2022-08-19 陈杰 Functional white kidney bean beverage and preparation method thereof

Similar Documents

Publication Publication Date Title
CN107440121A (en) A kind of Single Obesity tailored version clinical nutrition formula and preparation method thereof
CN107319525A (en) One kind fat-reducing fat reducing tailored version clinical nutrition formula and preparation method thereof
CN109645320A (en) A kind of light jejunitas full nutrient formulation can brew instant stick and preparation method thereof
CN106962912A (en) A kind of hepatopathy tailored version clinical nutrition formula and preparation method thereof
CN107440120A (en) A kind of children's monophagia and anorexia tailored version clinical nutrition formula particular about food and preparation method thereof
CN103099089B (en) Health-care product for reducing blood sugar and blood pressure, relaxing bowels, losing weight, resisting fatigue and improving sexual function and production technology thereof
CN106858620A (en) A kind of anaemia tailored version clinical nutrition formula and preparation method thereof
CN106579393A (en) Special clinical nutrient formula for diabetes and preparation method thereof
CN104544432B (en) Samara oil compound protein solid beverage and method for preparing same
CN102919836B (en) Health-care product capable of reducing blood glucose, releasing pressure, reducing lipid, relaxing bowel, beautifying, losing weight and resisting fatigue and production process thereof
CN107616490A (en) A kind of postoperative tailored version clinical nutrition formula of children and preparation method thereof
CN106983136A (en) A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof
CN101473953B (en) Fabricated food for cleaning blood and expelling toxin as well as method for processing the same and application
CN110326782A (en) A kind of nutritional meal replacement and preparation method thereof with effect of weight reducing
KR101738912B1 (en) Composition For Anti-obesity And Diet
CN106983151A (en) A kind of inflammatory bowel disease tailored version clinical nutrition formula and preparation method thereof
CN110074397A (en) A kind of upgrowth and development of children tailored version clinical nutrition formula and preparation method thereof
CN108077911A (en) A kind of epileptic's tailored version clinical nutrition formula and preparation method thereof
CN107319524A (en) A kind of nephrosis tailored version clinical nutrition formula and preparation method thereof
CN107440103A (en) A kind of respiratory disease tailored version clinical nutrition formula and preparation method thereof
CN107927754A (en) Tailored version clinical nutrition formula and preparation method thereof is energized during one kind production
CN110771825A (en) Comprehensive nutrition powder for reducing fat, blood sugar, blood pressure and blood fat and preparation method thereof
CN111053190A (en) Light-weight food composition for weight-losing meal replacement and preparation method thereof
CN107183526A (en) A kind of quinoa full nutrition formula food and its preparation method and application
CN108703365A (en) Protein allergy tailored version clinical nutrition formula and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20171208