CN108936628A - A kind of specific full nutritional formulas and preparation method thereof that patients with cerebral apoplexy is edible - Google Patents

Abstract

The invention discloses the specific full nutritional formulas that a kind of patients with cerebral apoplexy is eaten.The formula is according to the requirement of " special medicine purposes formula food general rule ", in conjunction with the constitutive character of patients with cerebral apoplexy, the research achievements such as advanced physiology, medicine, nutrition and the clinical application of comprehensive nowadays American Harvard University, the marrow of the Traditional Chinese Medicine according to " middle residence that disappears is mended ", " balanced tone " theoretical (the dirty people having the same aspiration and interest of liver,spleen,kidney three is main principle) develop.The product uses the Chinese medical extract essence of a variety of dual-purpose of drug and food, a variety of probiotics, small peptide for primary raw material, mixes using prebiotics, carbohydrate, amino acid, fatty powder, multivitamin and minerals as auxiliary material.In addition, a kind of preparation method of the specific full nutritional formulas eaten the present invention also provides patients with cerebral apoplexy.It can be used as the nutritional need that single source of nutrition meets patients with cerebral apoplexy, also act and inhibit nerve cell apoptosis, improve immunity and adjust the function of stomach and intestine.

Description

A kind of specific full nutritional formulas and preparation method thereof that patients with cerebral apoplexy is edible

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and food processing technology fields, specifically by " Chinese medicine of integration of drinking and medicinal herbs " Traditional Chinese Medicine marrow theory and " multiple probiotics " combine, and add with albumen small peptide, prebiotics, amino acid, carbon water Compound, fat, multi-vitamins, composite mineral matter are cerebral apoplexy full nutrition formula food and its preparation side made of auxiliary material Method.

Background technique

Cerebral apoplexy (cerebral apoplexy) is a kind of brain blood circulation disorder disease of unexpected onset, is shown as Cerebral ischemic and heamorrhagic lesions have high case fatality rate and disability rate.Cerebral apoplexy is broadly divided into hemorrhagic apoplexy (brain Bleeding or subarachnoid hemorrhage) and cerebral arterial thrombosis (cerebral infarction, cerebral thrombosis) two major classes, wherein cerebral arterial thrombosis (ischemic stroke) accounts for the 86% of whole cerebral apoplexies.Cerebral apoplexy be endanger middle-aged and the old's health principal disease it One, it is commonly encountered diseases of internal department, frequently-occurring disease.Cerebral apoplexy every annual morbidity in China's is 0.219%, disability rate 75.0%；

When cerebral arterial thrombosis, angiemphraxis can occur in any artery for arriving brain.Such as the deposition of lipid can occur In arteria carotis, so that so that blood flow is attenuated such as the pipeline of obstacle as water flow by one, this situation is quite serious, because of every side Arteria carotis usually provides most brain blood supply, and lipid can also fall off from carotid wall, with blood flow, blocks petty action Arteries and veins, being finally allowed to block arteria carotis, vertebral artery and its branch completely can be caused to block by other reasons.Such as in heart and heart valve The thrombus breaks loose that film is formed, with artery blood flow to brain, its result causes embolic cerebral apoplexy, and the cerebral apoplexy of this type is most common In receiving cardiac operation recently, have the patient of cardiac valve lesion and arrhythmia cordis, fat embolism is the rare original of cerebral apoplexy Cause will form many embolus brain blood if the fat from fracture site marrow enters blood flow and finally merges in intra-arterial Pipe is narrow because of inflammation or infection to may also lead to cerebral apoplexy, and the drugs such as cocaine and amphetamine can also make hemadostewnosis to lead Cerebral apoplexy is caused, blood pressure decline suddenly often seriously reduces brain blood flow, causes to faint, if low blood pressure seriously and continues in the presence of can also Massive blood loss, myocardial infarction or heart murmur caused by causing cerebral apoplexy, this situation that can betide wound and perform the operation；

For food of special nutrients, there are corresponding regulation and development and application in developed countries such as the U.S., European Union；And China Wholefood clear stipulaties in GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: 2.1.1 full nutrition formula food: it can be used as the special medicine purposes formula that single source of nutrition meets target group's nutritional need Food；2.1.2 specific full nutritional formulas: it can be used as single source of nutrition and meet target group in specified disease or medicine shape The special medicine purposes formula food of nutritional need under condition；

Traditional Chinese medicine thinks: " spleen (i.e. digestive system) is the foundation of acquired constitution ", stomach health are health sheets, human nutrition 99% needs by intestinal absorption, and intestinal bowel disease is also source of ten thousand diseases；But with age, profitable strain (probiotics) in enteron aisle Ratio gradually decreases；If Bifidobacterium Bifidum accounts for 98% in infant period, 5% is only accounted for after 10%, 65 years old is down to when to the middle age；People gets over Always, probiotics is fewer, and function of intestinal canal is also gradually reduced therewith, more and more studies have shown that normal floras in human consumption, exempt from Epidemic disease and disease-resistant etc. there are many irreplaceable roles；The change and a variety of diseases, especially enteron aisle disease of intestinal flora composition The occurrence and development of disease are closely related, and find from existing clinical research: probiotics can play adjusting intestinal flora, control enteritis Disease effect is that one kind safely and effectively intervenes adjusting method；

The relationship of Dysbiosis and cerebral apoplexy: being in high de-agglomeration hypermetabolism symptom, at body for cerebral apoplexy Cavity in Critical Patients more In negative nitrogen balance state, intestinal microecology balance is destroyed, and obstacle, Jin Erying occurs in easy damaged gut barrier, gastrointestinal function Patient clinical treatment and prognosis are rung, may result in enterogenic infection.Probiotics can be by improving mucous membrane surface microorganism Flora achievees the purpose that stimulate immunity of organism mechanism, and then promotes immunity of organisms, especially Bacillus acidi lactici, and main includes planting Object lactobacillus, bifidobacterium breve, bifidobacterium longum etc. adjust intestinal flora composition.Though direct probiotic oral has certain effect, But since probiotics can not be colonized in enteron aisle, and stop, occupy-place it is seldom, be easy to run off, it is easy to recur to withdraw rear harmful bacteria, related Patient needs to take for a long time, and treatment cycle is long, often very high using rear recurrence rate；For shorten associated patient treatment cycle, Recurrence rate after being discontinued is reduced, this seminar is studied by being colonized the key technology of mechanism over nearly 3 years in enteron aisle to probiotics, Make great efforts to seek to improve " Chinese medicine of integration of drinking and medicinal herbs " compound that probiotics is colonized in enteron aisle, it is contemplated that probiotics is colonized in enteron aisle Several key elements: the presence of prebiotics can play field planting effect, intestinal pH environment reduction and improve probiotic cell Enteron aisle adhesive capacity etc. is based on above-mentioned element, and suitable food materials screen from tens of kinds " Chinese medicine of integration of drinking and medicinal herbs " in this seminar, Prebiotics are added, after L-Glutamine etc., have very strong field planting effect to external source probio, are benefit in enteral microecological formulation The prescription selection of raw bacterium provides experimental basis；

At present favorably to the middle medicinal substances and short skin, compound protein, unsaturated fatty acid, a variety of ammonia in integration of drinking and medicinal herbs Base acid, vitamin and mineral combine the manufactured medicine formula food for being used for patients with cerebral apoplexy rehabilitation；There are also multiple using Chinese medicine Side is the product of primary raw material；The constitutive character that patients with cerebral apoplexy is combined but without discovery, the marrow according to Traditional Chinese Medicine are managed By varying with each individual, gold compatibility is with the Chinese medical extract essence of more than ten kinds of dual-purpose of drug and food, a variety of probiotics, protein, small peptide Primary raw material, using prebiotics, carbohydrate, amino acid, fat, multivitamin and several mineral materials to be complete made of auxiliary material Nutritional formulas, specific full nutritional formulas or similar products.

Summary of the invention

It is initiative by a variety of raising patients with cerebral apoplexy the purpose of the present invention is on inheriting Chinese medicine marrow theory treatment method The probiotics of immunity and the extract of " Chinese medicine of integration of drinking and medicinal herbs " compound combine, add with albumen small peptide, ammonia Base acid, carbohydrate, fat, multivitamin, several mineral materials are auxiliary material, and it is required can not only to supplement patients with cerebral apoplexy institute Nutrient improves body nutrition condition, moreover it is possible to adjust body function, probiotics using the function factor in dual-purpose of drug and food Chinese herbal medicine Adjusting intestinal flora can be played, toxic side effect is small, safe and effective, and the spy that the acceptable suitable patients with cerebral apoplexy of people is edible Determine full nutrition formula food and preparation method thereof.

The requirement of this R&D team basis " special medicine purposes formula food general rule ", the constitution in conjunction with patients with cerebral apoplexy are special Sign, the research achievements such as advanced physiology, medicine, nutrition and the clinical application of comprehensive nowadays American Harvard University, according to " in disappearing The marrow of the Traditional Chinese Medicine of residence benefit ", " balanced tone " is theoretical (the dirty people having the same aspiration and interest of liver,spleen,kidney three is main principle), uses 10 kinds to add medicine to Eat it is dual-purpose extract obtain extract essence, a variety of probiotics, albumen small peptide be primary raw material, with prebiotics, carbohydrate, Amino acid, fat, multivitamin and minerals auxiliary material, take specific preparation process, are uniformly mixed and powderous preparations are made, no It only can be used as the nutritional need that single source of nutrition meets patients with cerebral apoplexy, there are also benefiting qi and nourishing blood, inhibition nerve cell apoptosis, mention The full nutrition formula food of high immunity and the function of adjusting stomach and intestine, specific full nutritional formulas or non-full nutrient formulation food Product；

1, the extract component of inventive formulation

Integration of drinking and medicinal herbs extract is to be adjusted to together according to the constitutive character of patients with cerebral apoplexy from the liver,spleen,kidney three in theory of traditional Chinese medical science is dirty Main principle adjusts body function using the function factor in dual-purpose of drug and food Chinese herbal medicine and builds up resistance, and chooses following several major class Drug carries out compatibility；Wherein: Cordyceps militaris enters lung kidney two warp, can tonifying lung yin and kidney-replenishing, cure mainly kidney deficiency, impotence and seminal emission, waist Knee joint soreness, eak after being ill, chronic cough is weak, phthisical cough phlegm blood, spontaneous sweating etc..Ginseng can reinforce vital energy, veins takes off admittedly, tonifying spleen benefit Lung, shengjin nourishing, tranquilize the mind and promote the intelligence.Rhizoma polygonati is sweet in flavor mild-natured, can boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.Fructus lycii is sweet in flavor, mild-natured, Nourishing the liver, nourshing kidney, moistening lung cure mainly caused by liver and kidney deficiency, have a dizzy spell, is visually unclear, soreness and weakness of waist and knees.Poria cocos medicinal peace, contained Poria cocos Acid has the function of strengthen immunity, antitumor and calm, hypoglycemic etc..Semen ziziphi spinosae is sweet in flavor acid flat, can nourishing heart tonifying liver, peaceful Heart and tranquilizing mind, promotes the production of body fluid at arrest sweating.It is thin to nourish brain containing unsaturated fatty acid necessary to more protein and human nutrition for walnut kernel Born of the same parents enhance brain function；

Chinese medical extract of the present invention refers to Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), Cordyceps militaris, fructus alpiniae oxyphyllae, arillus longan, Noni fruit, acid It is jujube kernel, dried orange peel, rhizoma polygonati, pueraria lobata, fructus lycii, peach kernel, phoenix peony, Poria cocos, purple perilla seed, nutmeg, emblic, hawthorn, small Ji, Longstamen Onion Bulb, rhizoma imperatae, sea-buckthorn, eucommia Bark male flower, sanchi flower, Chinese yam, ginseng (artificial growth), 10 kinds therein of Saussurea involucrata culture Above or all, by the way that cellulase, pectase, papain and starch are added after the 60min-100min that is soaked in water Enzyme, 1 mg/g substrate of enzyme dosage, pH value is 4.0-5.0, in 50-80 DEG C of enzymatic hydrolysis 1-3h, solid-liquid ratio 1:15, with biological enzyme After solution technology extracts Chinese medicine essence, extraction mixture that is spray-dried and being prepared into flour；

2, a variety of probiotics

So that probiotics is largely reached enteron aisle by the strong acid environment of stomach, to promote the proliferation of probiotics, adjusts the micro- life of enteral State balance, promotes the absorption to microelement, enhances taste motor function, accelerates the absorption of drug effect, improve the micro- of mucous membrane surface The balance of biota or enzyme, or stimulation body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity； Xing etc. pre-processes law during ischemia/reperfusion rat with Bifidobacterium and Bacillus acidi lactici, can be substantially reduced intestinal endotoxemia Horizontal and preventing liver injury generation；Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, there is research It does not absorb that rifamycin antibiotic former times is bright (rifaximin) using enteron aisle, passes through the life for inhibiting urease-producing in enteron aisle and producing ammonium bacteria It is long, to build up resistance；

A variety of probiotics of the present invention all use the probiotics after microencapsulation, in addition to streptococcus thermophilus, wherein bifid Bacillus: refer to bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, long bifid Bacillus is one of, several or whole mixes；Lactobacillus refers to: lactobacillus acidophilus powder, Lactobacillus casei, bulgarian milk bar Bacterium, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus are one of, several or whole mixes；

3, albumen small peptide

Small peptide is oligopeptide, refers to small point of one kind of the separation and Extraction from animal or vegetable protein using bio-enzyme engineering technology Sub- protein, average molecular weight in 1000Dalton hereinafter, soluble easily in water, to acid, thermostabilization, can be not required to by digestion and It directly absorbs, bioavailability is high, is absorbing and using upper better than free amino acid and complete protein, can be applied to egg In white matter supplement, particularly with the low crowd of abilities of digestive and absorption, small peptide is splendid nitrogen source, in addition to trophic function, Small peptide also has a series of physiological active functions: the digestion and absorption function of small intestine improved, immunity of organisms is enhanced, it is anti-oxidant, Auxiliary adjustment blood glucose, auxiliary adjustment of blood fat, aided blood pressure-lowering is anti-radiation, promotes mineral absorption, enhances dual-purpose of drug and food medium-height grass The function and effect of function factor in medicine；

Albumen small peptide of the present invention refer to ocean fish oligopeptide, dragon protein, sea bone peptide, soybean protein, whey egg White peptide, ovalbumin peptide are one of, several or whole mixes；

4, prebiotics

To promote probiotics intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most of enteron aisle spoilage organisms, But beneficial bacteria in human body can be promoted --- lactobacillus, Bifidobacterium growth and breeding, so as to inhibit spoilage organisms to grow, Help to improve and maintain enteron aisle normal function；Long-term consumption can delay aging, defaecation, improve immunity, mitigation liver is born Load, the absorptivity for improving nutrient, can especially improve body to Metal Ions Absorptions such as calcium, iron, zinc；Optionally promote Into outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also metabolizable is the organic acids such as acid product such as lactic acid, makes colon pH Value reduces, and inhibits the growth of intestinal harmful bacillus；So that small enteral Water-Electrolyte is trapped in enteric cavity, generate height and ooze effect, stimulates intestines Wriggling causes laxative, to promote intestinal endotoxin and the discharge of other toxicants, lactulose can also be inactivated directly in enteron aisle Endotoxin reduces gut pH, has been widely applied to the treatment of enhancing child resistant；

Prebiotics of the present invention are 2 classes

A. there are very strong field planting effect prebiotics: fructus lycii, ginseng, Poria cocos, the extract of jerusalem artichoke, wood to external source probio Sugar, yeast are therein several or all mix；

B. common prebiotics: oligoisomaltose, oligofructose, soyabean oligosaccharides, xylo-oligosaccharide are one such, several or complete Portion's mixing；

The present invention refers to that oligoisomaltose, stachyose, oligofructose, soyabean oligosaccharides, xylo-oligosaccharide are one such, several Or all mixing；

5, carbohydrate

Carbohydrate is made of three kinds of carbon, hydrogen and oxygen elements, it is that three kinds of main nutrition of thermal energy are provided for human body Most cheap nutrient in element, when intake is sufficient, in vivo can rapid oxidation energy is provided in time, avoid valuable protein For providing energy, carbohydrate be also the glycoprotein of cell membrane, nerve fiber glycolipid and convey hereditary information de- The important composition ingredient of oxygen ribonucleic acid (DNA), and the glycogen contained in carbohydrate, when it lays in abundance in liver When, the toxin that liver cell generates certain toxic chemical substances and various pathogenic microorganisms has stronger detoxification ability；

Carbohydrate of the present invention refers to glucose, fructose, galactolipin, lactose, L-arabinose, maltose, water-soluble Property dietary fiber, starch, glycogen be one such, several or all mixing；

6. amino acid

It is divided into essential amino acid and nonessential amino acid, is the basic unit for constituting protein, assigns the specific molecule of protein Structural form makes it have biochemical activity；Absorbing suitable methionine facilitates the metabolism of various sulfur-containing compounds in human body simultaneously And the methyl contained by it methylates to Toxic or drug and plays the role of removing toxic substances；Leucine can repair muscle, control Blood glucose processed, and energy is provided to bodily tissue, it is necessary to amino acid phenylalanine can inhibit cancer growth, and can reduce drug Toxic side effect, lysine can be improved the absorption and utilization of food protein, reaches balanced nutritious, enhancing development；Smart ammonia Acid helps the ammonia in blood being changed into urea and excrete out；For hyperammonemia, hepatic dysfunction etc. is powerful； Histidine reduces gastric acidity, mitigates the pain of gastrointestinal procedures, mitigates gestational period vomiting and scorching hot sense, inhibits by plant mind It festers through alimentary canal caused by anxiety, it is also powerful to anaphylactia, such as asthma；Tryptophan can prevent pellagra, Depression improves sleep and adjusts mood；

Amino acid of the present invention refer to L-Glutamine, methionine, isoleucine, tyrosine, phenylalanine, lysine, Arginine, histidine, tryptophan, citrulling, ornithine, taurine, γ-aminobutyric acid, tealeaves theanine are one such, several Kind or all mixing；

7. fatty powder

Fat is commonly called as grease, is made of carbon, hydrogen and oxygen element；It is both important composition part and the heat of tissue One of main matter of amount；Fat in food digests in stomach, most of after absorption to be changed into fat once again again；It is main Be distributed in around subcutis, omentum majus, mesenterium and kidney etc.；The trigalloyl that fat is made of glycerol and fatty acid Glyceride, wherein the molecule of glycerol is fairly simple, and the type of fatty acid and length is not identical；Fatty acid divides three categories: full With fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid;The source of fat can divide following two kinds: animality source: animal The fat stored in vivo: such as lard, butter, sheep oil, fish oil, marrow, fat meat, cod-liver oil；Fat in animal cream: such as cream Deng；Vegetalitas source: vegetablefats source is mainly extracted out of fruit in plant, such as sesame, sunflower seed, tea life, core Peach, pine nut, soya bean etc.；It is compound by a variety of fatty acid, adjust saturated fatty acid, monounsaturated fatty acids, polyunsaturated fat The content ratio of acid is that the ratio of 1:1:1, ω -6 and ω -3 are 10:1 ~ 2:1, preferably 5:1 ~ 2:1, preferred 2:1；It has been especially added with 2- 8 parts of omega-fatty acid, source include addition embedding material after the combination of one or both of fish oil, algae oil, are obtained through homogeneous Then emulsion is obtained fatty powder using screening by being dried in spray drying device by emulsion；

Fat of the present invention refers to MCT powder, alpha-linolenic acid, linoleic acid, conjugated linoleic acid, corn oil, soybean oil, peanut Oil, sunflower oil, olive oil, linseed oil, embryo oil are one such, several or whole mixes；

8. vitamin and mineral

Vitamin and mineral is nutrient needed by human, and the vitamin added in the present invention is that vitamin and mineral is people Nutrient necessary to body；

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K₁, vitamin C, dimension Raw element B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, niacin, folic acid, pantothenic acid, choline, biotin it is therein several or all mixed It closes；

The minerals added in the present invention are that calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum are therein Several or whole mixing, minerals of the present invention are added to the organic or inorganic compound of the minerals；

The vitamin and minerals mixture added in the present invention, be in strict accordance with equal increments method principle, specific blend technique into The mixture that row is mixed to get.Mixing rate is 12-15r/min, incorporation time 20-40min；

9. the preparation method is that referring to Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), Cordyceps militaris, fructus alpiniae oxyphyllae, arillus longan, Noni fruit, wild jujube Benevolence, dried orange peel, rhizoma polygonati, pueraria lobata, fructus lycii, peach kernel, phoenix peony, Poria cocos, purple perilla seed, nutmeg, emblic, hawthorn, field thistle, Longstamen Onion Bulb, rhizoma imperatae, sea-buckthorn, eucommia Bark male flower, sanchi flower, Chinese yam, ginseng (artificial growth), 10 kinds therein of Saussurea involucrata culture or more Or all by the way that cellulase, pectase, papain and amylase are added after the 60min-100min that is soaked in water, enzyme is used 1 mg/g substrate is measured, pH value is 4.0-5.0, in 50-80 DEG C of enzymatic hydrolysis 1-3h, solid-liquid ratio 1:15, with biological enzymolysis technology After extracting Chinese medicine essence, extraction mixture that is spray-dried and being prepared into flour；The egg of biological enzymolysis extraction is added again The sub- oil of white small peptide, prebiotics, amino acid, water-soluble dietary fiber, haematococcus pluvialis, MCT powder, alpha-linolenic acid, linoleic acid, conjugation Acid carries out first time mixing, incorporation time 20-40min, mixing rate 30-45r/min；It is added again by stringent specific mixed Technique: mixing rate 12-15r/min is closed, the multi-vitamins and minerals that incorporation time is 20-40min carry out Pasteur and go out Bacterium 1 hour, Bifidobacterium after then adding microencapsulation was (bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, short Bifidobacterium, bifidobacterium infantis, bifidobacterium longum), lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, bulgarian milk bar Bacterium, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus), streptococcus thermophilus and mix, incorporation time is 20-40min, mixing rate 30-45r/min obtain uniformly mixed powderous preparations technique.

The characteristic of this formula full nutrition formula food and its following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of patients with cerebral apoplexy, The research achievements developments such as advanced physiology, medicine, nutrition and the clinical application of comprehensive nowadays American Harvard University, due to people It is different, gold compatibility；

2. the marrow of the Traditional Chinese Medicine of present invention foundation " middle residence that disappears is mended ", " balanced tone " is theoretical, (liver,spleen,kidney three is dirty to be adjusted to together Main principle), use the Chinese medical extract essence of a variety of dual-purpose of drug and food, a variety of probiotics, albumen small peptide for primary raw material, with prebiotic Member, carbohydrate, amino acid, multivitamin and minerals be auxiliary material, the organic assembling of various ingredients, by various functions into Row fusion, and pass through the synergistic effect between effective component, humidification effect；

3. there is effective absorbency, using inventive formulation, food of the various components using suitable ratio collocation preparation, warp It is in isotonic state after a certain amount of water dissolution, small intestine can be reached quickly through stomach, absorbed quickly, completely, brain soldier can be supplemented rapidly Nutrition needed for middle patient；

4. not only being mentioned using the extract of various dual-purpose of drug and food Chinese herbal medicines containing multiple functions active constituent in inventive formulation The high concentration of function factor, reduces the intake of various impurity, helps to mitigate liver kidney burden, have enhancing resistance of human body Effect there are also Bushen Yizhi, benefiting qi and nourishing blood, dissipating phlegm for resuscitation and improves efficacy of immunity；

5. probiotics contained in inventive formulation, a variety of probiotics can safeguard enteron aisle normal bacteria colony balance, inhibit disease The growth of opportunistic pathogen prevents gastrointestinal disorders etc., and vitamin, amino acid are synthesized in enteron aisle and improves absorption of the body to calcium ion, Enhance human immunologic function, prevent the side effect of antibiotic, improves host to the tolerance of radioactive ray, lactobacillus dramatically increases intestines Mucosal immunity globulin A (SIgA) content has adjustment effect to body intestinal mucosa local immunity, adjusts stomach, intestines Tiny ecosystem, energy The utilization rate of calcium, phosphorus, iron is improved, promotes the absorption of iron and vitamin D, the absorption of cholesterol can also be reduced；

6. inventive formulation food is using the food-borne bioactive short peptide in a variety of sources as nitrogen source, because small peptide is not required to digestion i.e. It is absorbable, it is more advantageous to the utilization of body, patients with cerebral apoplexy negative nitrogen balance can be effectively improved, and food-borne small peptide can change The structure and function of kind intestinal epithelial cell, improves the absorbability of intestinal mucosa；

7. prescription uses what this team was studied by being colonized the key technology of mechanism over nearly 3 years in enteron aisle to probiotics Achievement improves " Chinese medicine of integration of drinking and medicinal herbs " compound that probiotics is colonized in enteron aisle, and the presence for combining prebiotics, which can be played, to be determined The elements such as the enteron aisle adhesive capacity of plant effect, the reduction of intestinal pH environment and raising probiotic cell, therefore the food formula Composition greatly strengthens the field planting effect to external source probio；

8. prebiotics contained in inventive formulation inhibit the growth of spoilage organisms by the growth and breeding of promotion enteral probiotics, One of protective barrier is formed in intestinal mucosal surface simultaneously, damage of the enteron aisle spoilage organisms to intestinal mucosa can be resisted, reducing enteral has The absorption of evil substance, can also promote intestines peristalsis, accelerate the discharge of enteral residuals, can prevent constipation, and pass through Promote the growth and breeding of beneficial bacteria of intestinal tract that immunity of organisms also can be enhanced, small peptide, carbohydrate and active polysaccharide etc. are biological Active material has synergistic effect；

9, carbohydrate contained in inventive formulation is that three kinds of main nutrients of thermal energy are provided for human body, in vivo Can rapid oxidation energy is provided in time, avoid being used to valuable protein to provide energy, carbohydrate is also cell membrane The important composition ingredient of glycoprotein, the glycolipid of nerve fiber and the DNA (DNA) to convey hereditary information, and carbon The glycogen contained in hydrate, when it lays in abundance in liver, liver cell is to certain toxic chemical substances and various causes The toxin that sick microorganism generates has stronger detoxification ability；

10, amino acid contained in inventive formulation is the basic unit for constituting protein, assigns the specific molecule knot of protein It is configured state, makes it have biochemical activity, facilitates the metabolism of various sulfur-containing compounds in human body and the methyl contained by it is to having Poisonous substance or drug are methylated and play the role of removing toxic substances, and muscle can be repaired, and control blood glucose, and provide energy to bodily tissue Amount, also can be improved the absorption and utilization of food protein, reaches balanced nutritious；

11, inventive formulation food contains multivitamin and minerals, micronutrient needed for can supplementing rapidly patients with cerebral apoplexy Element, small peptide is by further increasing the absorptivity of mineral matter element with after the chelating of calcium, iron, zinc etc.；

12, fatty in inventive formulation, maize germ oil, sunflower oil lack ω -3-PUFA rich in ω -6-PUFA；Olive Oil, tea-seed oil are rich in monounsaturated fatty acids (MUFA), can increase rouge while supplementing protein, micronutrient The intake of fat avoids the adverse effect of the high protein diets such as meat, egg.

Specific embodiment

Below by following embodiment, the invention will be further described, it will be helpful to understand the present invention；

Realize that the object of the invention cerebral apoplexy full nutrition formula food is the constitutive character to combine patients with cerebral apoplexy, according in tradition The marrow of doctor is theoretical, varies with each individual, gold compatibility with the Chinese medical extract essence of 10 kinds or more dual-purpose of drug and food, a variety of probiotics, Albumen small peptide is primary raw material, supplemented by prebiotics, carbohydrate, amino acid, fat, multivitamin, several mineral materials Food made of expecting；Bifidobacterium is selected from bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, baby Bifidobacterium, bifidobacterium longum one or more；Lactobacillus is selected from lactobacillus acidophilus powder, Lactobacillus casei, bulgarian milk Bacillus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, rhamnose cream bar Bacterium, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus one or more；Albumen small peptide is selected from sea Foreign fish oligopeptide, dragon protein, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide one or more； Prebiotics are selected from oligoisomaltose, stachyose, oligofructose, the one or more of soyabean oligosaccharides, xylo-oligosaccharide；Amino acid Selected from methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, bird ammonia Acid, taurine, γ-aminobutyric acid, the one or more of tealeaves theanine；Fat is selected from MCT powder, alpha-linolenic acid, linoleic acid, is total to The one or more of conjugated linoleic acid, corn oil, soybean oil, peanut oil, sunflower oil, olive oil, linseed oil, embryo oil；Dimension Raw element premix is selected from vitamin A, vitamin D, vitamin E, vitamin K₁, vitamin C, vitamin B₁, vitamin B₂, dimension life Plain B₆, vitamin B₁₂, niacin, folic acid, pantothenic acid, choline, one or more of biotin etc.；Mineral substance premix be selected from calcium, One or more of phosphorus, potassium, sodium, magnesium, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum etc.；

Manufacturing process of the invention is with 10 kinds or more or whole integration of drinking and medicinal herbs raw materials are by being soaked in water after 60min-100min Cellulase, pectase, papain and amylase, 1 mg/g substrate of enzyme dosage is added, pH value is 4.0-5.0, 50-80 DEG C of enzymatic hydrolysis 1-3h, solid-liquid ratio 1:15 through being spray-dried are prepared into pulverulent mixture after extracting Chinese medicine essence；It adds again Albumen small peptide, the prebiotics, amino acid, water-soluble dietary fiber, haematococcus pluvialis, MCT powder, α-flax of biological enzymolysis extraction Acid, linoleic acid, conjugated linoleic acid carry out first time mixing, incorporation time 20-40min, mixing rate 30-45r/min；Again Stringent specific blend technique: mixing rate 12-15r/min is passed through in addition, and incorporation time is the multi-vitamins of 20-40min And mixed after minerals progress pasteurization 1 hour with a variety of probiotics, incorporation time 20-40min, mixing rate is 30-45r/min obtains the preparation process of uniformly mixed powdery.

Embodiment one

Select following formula and ratio to be made and be mixed for cerebral apoplexy full nutrition formula food: by following raw materials according and its dosage into Row formula: the extract of dual-purpose of drug and food: 15 parts of Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), 15 parts of Cordyceps militaris, 15 parts of fructus alpiniae oxyphyllae, arillus longan 15 Part, 15 parts of Noni fruit, 15 parts of semen ziziphi spinosae, 15 parts of dried orange peel, 15 parts of rhizoma polygonati, 15 parts of pueraria lobata, 15 parts of fructus lycii, 15 parts of peach kernel, phoenix 10 parts of peony, 10 parts of Poria cocos, 10 parts of purple perilla seed, 10 parts of nutmeg, 10 parts of emblic, 10 parts of hawthorn, 10 parts of field thistle, Longstamen Onion Bulb 10 Part, 10 parts of rhizoma imperatae, 10 parts of sea-buckthorn, 8 parts of eucommia Bark male flower, 8 parts of sanchi flower, 8 parts of Chinese yam, 5 parts of ginseng (artificial growth), saussurea involucrata training Support 5 parts of object；75 parts of Bifidobacterium, 75 parts of lactobacillus, 40 parts of streptococcus thermophilus, 100 parts of L-Glutamine, 100 parts of albumen small peptide, 100 parts of prebiotics, 100 parts of water-soluble dietary fiber, 5 parts of haematococcus pluvialis, 150 parts of fatty powder, are answered at 100 parts of compound amino acid Close 5 parts of vitamin, 50 parts of composite mineral matter；

When production first by Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), Cordyceps militaris, fructus alpiniae oxyphyllae, arillus longan, Noni fruit, semen ziziphi spinosae, dried orange peel, rhizoma polygonati, Pueraria lobata, fructus lycii, peach kernel, phoenix peony, Poria cocos, purple perilla seed, nutmeg, emblic, hawthorn, field thistle, Longstamen Onion Bulb, rhizoma imperatae, Sea-buckthorn, eucommia Bark male flower, sanchi flower, Chinese yam, ginseng (artificial growth), Saussurea involucrata culture are soaked in water after 60min and cellulose are added Enzyme, pectase, papain and amylase, 1 mg/g substrate of enzyme dosage, pH value are 4.0, in 50 DEG C of enzymatic hydrolysis 3h, material Liquor ratio 1:15 through being spray-dried is prepared into pulverulent mixture after extracting Chinese medicine essence；

Secondly addition biological enzymolysis extract albumen small peptide, prebiotics, amino acid, water-soluble dietary fiber, haematococcus pluvialis, MCT powder, alpha-linolenic acid, linoleic acid, conjugated linoleic acid carry out first time mixing, incorporation time 20min, mixing rate 45r/ min；

Stringent specific blend technique: mixing rate 12r/min is passed through in addition again, and the compound dimension that incorporation time is 40min is raw Carries out pasteurization 1 hour after element and minerals mixing, then a variety of Bifidobacteriums after addition microencapsulation, lactobacillus, thermophilic Hot streptococcus simultaneously mixes incorporation time as 40min, and mixing rate 30r/min obtains the preparation process of uniformly mixed powdery；

Embodiment two

Above-mentioned cerebral apoplexy full nutrition formula food is also an option that following formula and ratio are made and is mixed for cerebral apoplexy and seeks entirely Support formula food: the extract of dual-purpose of drug and food: 18 parts of Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), 18 parts of Cordyceps militaris, 18 parts of fructus alpiniae oxyphyllae, arillus longan 18 parts, 18 parts of Noni fruit, 18 parts of semen ziziphi spinosae, 18 parts of dried orange peel, 18 parts of rhizoma polygonati, 18 parts of pueraria lobata, 15 parts of fructus lycii, 15 parts of peach kernel, pellet 15 parts of phoenix peony, 12 parts of Poria cocos, 12 parts of purple perilla seed, 10 parts of nutmeg, 10 parts of emblic, 10 parts of hawthorn, 8 parts of field thistle, Longstamen Onion Bulb 8 Part, 8 parts of rhizoma imperatae, 8 parts of sea-buckthorn, 5 parts of eucommia Bark male flower, 5 parts of sanchi flower, 5 parts of Chinese yam, 5 parts of ginseng (artificial growth), saussurea involucrata culture 5 parts of object；85 parts of Bifidobacterium, 55 parts of lactobacillus, 50 parts of streptococcus thermophilus, 100 parts of L-Glutamine, 100 parts of albumen small peptide, benefit It is raw 100 parts of member, 100 parts of compound amino acid, 100 parts of water-soluble dietary fiber, 150 parts of fatty powder, 5 parts of multi-vitamins, compound 50 parts of minerals；

When production first by Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), Cordyceps militaris, fructus alpiniae oxyphyllae, arillus longan, Noni fruit, semen ziziphi spinosae, dried orange peel, rhizoma polygonati, Pueraria lobata, fructus lycii, peach kernel, phoenix peony, Poria cocos, purple perilla seed, nutmeg, emblic, hawthorn, field thistle, Longstamen Onion Bulb, rhizoma imperatae, Sea-buckthorn, eucommia Bark male flower, sanchi flower, Chinese yam, ginseng (artificial growth), Saussurea involucrata culture are soaked in water after 80min and cellulose are added Enzyme, pectase, papain and amylase, 1 mg/g substrate of enzyme dosage, pH value are 4.5, in 60 DEG C of enzymatic hydrolysis 2h, material Liquor ratio 1:15 through being spray-dried is prepared into pulverulent mixture after extracting Chinese medicine essence；

Secondly addition biological enzymolysis extract albumen small peptide, prebiotics, amino acid, water-soluble dietary fiber, haematococcus pluvialis, MCT powder, alpha-linolenic acid, linoleic acid, conjugated linoleic acid carry out first time mixing, incorporation time 30min, mixing rate 35r/ min；

Stringent specific blend technique: mixing rate 15r/min is passed through in addition again, and the compound dimension that incorporation time is 20min is raw Carries out pasteurization 1 hour after element and minerals mixing, then a variety of Bifidobacteriums after addition microencapsulation, lactobacillus, thermophilic Hot streptococcus simultaneously mixes incorporation time as 30min, and mixing rate 35r/min obtains the preparation process of uniformly mixed powdery；

Embodiment three

Above-mentioned cerebral apoplexy full nutrition formula food is also an option that following formula and ratio are made and is mixed for cerebral apoplexy and seeks entirely Support formula food: the extract of dual-purpose of drug and food: 18 parts of Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), 18 parts of Cordyceps militaris, 18 parts of fructus alpiniae oxyphyllae, arillus longan 18 parts, 18 parts of Noni fruit, 18 parts of semen ziziphi spinosae, 18 parts of dried orange peel, 18 parts of rhizoma polygonati, 18 parts of pueraria lobata, 15 parts of fructus lycii, 15 parts of peach kernel, pellet 15 parts of phoenix peony, 12 parts of Poria cocos, 12 parts of purple perilla seed, 10 parts of nutmeg, 10 parts of emblic, 8 parts of field thistle, 8 parts of Longstamen Onion Bulb, rhizoma imperatae 8 parts, 8 parts of sea-buckthorn, 5 parts of eucommia Bark male flower, 5 parts of sanchi flower, 5 parts of Chinese yam, 5 parts of Saussurea involucrata culture；75 parts of Bifidobacterium, lactobacillus 65 Part, 50 parts of streptococcus thermophilus, 100 parts of L-Glutamine, 100 parts of albumen small peptide, 100 parts of prebiotics, 100 parts of compound amino acid, 100 parts of water-soluble dietary fiber, 150 parts of fatty powder, 5 parts of multi-vitamins, 50 parts of composite mineral matter；

When production first by Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), Cordyceps militaris, fructus alpiniae oxyphyllae, arillus longan, Noni fruit, semen ziziphi spinosae, dried orange peel, rhizoma polygonati, Pueraria lobata, fructus lycii, peach kernel, phoenix peony, Poria cocos, purple perilla seed, nutmeg, emblic, hawthorn, field thistle, Longstamen Onion Bulb, rhizoma imperatae, Sea-buckthorn, eucommia Bark male flower, sanchi flower, Chinese yam, ginseng (artificial growth), Saussurea involucrata culture are soaked in water after 100min and cellulose are added Enzyme, pectase, papain and amylase, 1 mg/g substrate of enzyme dosage, pH value are 5.0, in 80 DEG C of enzymatic hydrolysis 1h, material Liquor ratio 1:15 through being spray-dried is prepared into pulverulent mixture after extracting Chinese medicine essence；

Secondly addition biological enzymolysis extract albumen small peptide, prebiotics, amino acid, water-soluble dietary fiber, haematococcus pluvialis, MCT powder, alpha-linolenic acid, linoleic acid, conjugated linoleic acid carry out first time mixing, incorporation time 40min, mixing rate 30r/ min；

Stringent specific blend technique: mixing rate 13r/min is passed through in addition again, and the compound dimension that incorporation time is 30min is raw Carries out pasteurization 1 hour after element and minerals mixing, then a variety of Bifidobacteriums after addition microencapsulation, lactobacillus, thermophilic Hot streptococcus simultaneously mixes incorporation time as 20min, and mixing rate 40r/min obtains the preparation process of uniformly mixed powdery.

Claims (3)

1. a kind of edible specific full nutritional formulas of patients with cerebral apoplexy, it is characterised in that its material composition content includes with weight The following component of meter: integration of drinking and medicinal herbs ingredient: 10-20 parts of Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), 10-20 parts of Cordyceps militaris, fructus alpiniae oxyphyllae 10-20 Part, 10-20 parts of arillus longan, 10-20 parts of Noni fruit, 10-20 parts of semen ziziphi spinosae, 10-20 parts of dried orange peel, 10-20 parts of rhizoma polygonati, pueraria lobata 10- 20 parts, 10-20 parts of fructus lycii, 10-20 parts of peach kernel, 8-15 parts of phoenix peony, 8-15 parts of Poria cocos, 8-15 parts of purple perilla seed, Pork and beans 8-15 parts cool, 8-15 parts of emblic, 8-15 parts of hawthorn, 8-15 parts of field thistle, 5-10 parts of Longstamen Onion Bulb, 5-10 parts of rhizoma imperatae, sea-buckthorn 5-10 Part, 5-10 parts of eucommia Bark male flower, 5-10 parts of sanchi flower, 5-10 parts of Chinese yam, 5-10 parts of ginseng (artificial growth), Saussurea involucrata culture 5-10 Part；A variety of probiotics: 50-100 parts of Bifidobacterium (bifidobacterium adolescentis, bifidobacterium lactis, not tally bifid bar after microencapsulation Bacterium, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum), 50-100 parts of lactobacillus (lactobacillus acidophilus powder, cheese cream bar Bacterium, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, saliva cream bar Bacterium, Lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus), streptococcus thermophilus 20-60 parts, 50-150 parts of L-Glutamine, 50-150 parts of albumen small peptide (dragon protein, ocean fish oligopeptide, sea bone peptide, Soybean protein, whey protein peptide, ovalbumin peptide), 50-150 parts of prebiotics (oligoisomaltose, stachyose, oligofructose, Soyabean oligosaccharides, xylo-oligosaccharide), 50-150 parts of compound amino acid (methionine, isoleucine, tyrosine, phenylalanine, rely ammonia Acid, arginine, histidine, tryptophan, citrulling, ornithine, taurine, γ-aminobutyric acid, tealeaves theanine), water-soluble meals Food fiber 50-150 parts, 5-10 parts of haematococcus pluvialis, 100-200 parts of fatty powder (MCT powder, alpha-linolenic acid, linoleic acid, corn oil, Soybean oil, peanut oil, sunflower oil, olive oil, linseed oil, embryo oil, conjugated linoleic acid), vitamin premix (vitamin A, vitamin D, vitamin E, vitamin K₁, vitamin C, vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, niacin, leaf Acid, pantothenic acid, choline, biotin) 5 parts；Mineral substance premix (calcium, phosphorus, potassium, sodium, magnesium, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, Molybdenum) 50 parts.

2. a kind of edible specific full nutritional formulas of patients with cerebral apoplexy according to claim 1, which is characterized in that first By Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), Cordyceps militaris, fructus alpiniae oxyphyllae, arillus longan, Noni fruit, semen ziziphi spinosae, dried orange peel, rhizoma polygonati, pueraria lobata, fructus lycii, Peach kernel, phoenix peony, Poria cocos, purple perilla seed, nutmeg, emblic, hawthorn, field thistle, Longstamen Onion Bulb, rhizoma imperatae, sea-buckthorn, Cortex Eucommiae are male Flower, sanchi flower, Chinese yam, ginseng (artificial growth), Saussurea involucrata culture are by being added cellulose after the 60min-100min that is soaked in water Enzyme, pectase, papain and amylase, 1 mg/g substrate of enzyme dosage, pH value is 4.0-5.0, at 50-80 DEG C 1-3h, solid-liquid ratio 1:15 are digested, through being spray-dried is prepared into pulverulent mixture after extracting Chinese medicine essence；Biological enzymolysis is added again The albumen small peptide of extraction, prebiotics, amino acid, water-soluble dietary fiber, haematococcus pluvialis, MCT powder, alpha-linolenic acid, linoleic acid, Conjugated linoleic acid carries out first time mixing, incorporation time 20-40min, mixing rate 30-45r/min；It is added again by tight Lattice specific blend technique: mixing rate 12-15r/min, incorporation time be 20-40min multi-vitamins and minerals into It is mixed after row pasteurization 1 hour with a variety of probiotics, incorporation time 20-40min, mixing rate 30-45r/ Min obtains the preparation process of uniformly mixed powdery.

3. a kind of edible specific full nutritional formulas of patients with cerebral apoplexy according to claim 1, which is characterized in that institute The integration of drinking and medicinal herbs ingredient stated includes following component: Gynura divaricata (Radix et Rhizoma Gynurae divaricatae), Cordyceps militaris, fructus alpiniae oxyphyllae, arillus longan, Noni fruit, acid It is jujube kernel, dried orange peel, rhizoma polygonati, pueraria lobata, fructus lycii, peach kernel, phoenix peony, Poria cocos, purple perilla seed, nutmeg, emblic, hawthorn, small Ji, Longstamen Onion Bulb, rhizoma imperatae, sea-buckthorn, eucommia Bark male flower, sanchi flower, Chinese yam, ginseng (artificial growth), 10 kinds therein of Saussurea involucrata culture Above or all；

A variety of probiotics include following component: streptococcus thermophilus, Bifidobacterium, lactobacillus；Wherein, Bifidobacterium refers to Bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum wherein one Kind, several or all mixing；Lactobacillus refers to lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, De Shi cream bar Bacterium, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, Luo Yishi cream bar Bacterium, lactobacillus plantarum, lactobacillus paracasei, Yue Shi lactobacillus are one of, several or whole mixes；

The albumen small peptide refer to ocean fish oligopeptide, dragon protein, sea bone peptide, soybean protein, whey protein peptide, ovum Ovalbumin peptide is one of, several or whole mixes；

The prebiotics refer to oligoisomaltose, stachyose, oligofructose, soyabean oligosaccharides, xylo-oligosaccharide therein one Kind, several or all mixing；

The compound amino acid refers to L-Glutamine, methionine, isoleucine, tyrosine, phenylalanine, lysine, essence Propylhomoserin, histidine, tryptophan, citrulling, ornithine, taurine, γ-aminobutyric acid, tealeaves theanine are one such, several Or all mixing；

The fatty powder refers to MCT powder, alpha-linolenic acid, linoleic acid, conjugated linoleic acid, corn oil, soybean oil, peanut oil, certain herbaceous plants with big flowers Flower seed oil, olive oil, linseed oil, embryo oil are one such, several or whole mixes.