Background technology
Diabetes are one group of metabolic diseases taking hyperglycaemia as feature, hyperglycaemia be due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause, long-standing hyperglycaemia when diabetes, cause various tissues, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction, diabetes can cause multiple complications, if diabetes do not obtain enough control, can cause some acute complicationses, as hypoglycemia, DKA, non-ketone hyperosmolar coma, serious long-term complications comprises: angiocardiopathy, chronic renal failure (claims again diabetic nephropathy, the main cause of haemodialysis in the adult of developing country), PVR (claims again diabetic eye diseases, can blinding, the principal disease of the non-aged adult's blinding of developing country), DPN and microangiopathies, wherein, microangiopathies may cause erectile dysfunction (impotence) and wound to be difficult to healing, the wound that foot is difficult to healing may cause gangrene (being commonly called as " diabetes "), and then cause patient's amputation, if diabetes have obtained enough control, and to blood pressure fully control and in conjunction with good habits and customs (as non-smoking, the body weight of keeping fit etc.), the danger of suffering from above-mentioned complication can effectively reduced, World Health Organization 2011 report point out that the whole world has 3.46 hundred million people to suffer from diabetes, within 2004, estimate at 3,400,000 people and die from the consequence that hyperglycaemia causes, exceed 80% Diabetes Death and occur in low income and middle income country, the origin cause of formation of diabetes roughly has following two kinds:
1. inherent causeall there is obvious genetic heterogeneity in 1 type or diabetes B, there is family's morbidity tendency in diabetes, 1/4~1/2 patient has diabetes family history, genetic syndromes more than having clinically 60 kinds at least can be with diabetes, type 1 diabetes has multiple DNA site to participate in morbidity, wherein close with DQ loci polymorphism relation in HLA antigen gene, find multiple clear and definite gene mutation at diabetes B, as insulin gene, insulin receptor gene, glucokinase gene, chondriogen etc.
2. environmental factorfeed too much, it is the topmost environmental factor of diabetes B that physical exertion reduces the obesity causing, the individuality with diabetes B genetic predisposition is easily fallen ill, and there is immune system abnormality in type 1 diabetes patient, viral as Coxsackie virus at some, rubella virus, after the infection such as parotid gland virus, cause autoimmune response, destroy insulin β cell, " integration of drinking and medicinal herbs " is one of contribution to mankind's most worthy among Chinese original medical science, the traditional Chinese medical science always emphasize " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet, allow people dispel slight illness in the process of enjoying cuisines, avoided having an injection, taking medicine, even the hardship of operation.
For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And wholefood clearly specifies in China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: the full nutrient formulation food of 2.1.1: the special medicine purposes formula food that can be used as single source of nutrition and meet target group's nutritional need; 2.1.2 specific full nutrient formulation food: the special medicine purposes formula food that can be used as single source of nutrition and meet target group's nutritional need under specified disease or medical condition.
Traditional Chinese medical science traditional medicine is thought: " spleen (being digestive system) is the foundation of acquired constitution ", stomach health is healthy basis, and 99% of human nutrition need to lean on intestinal absorption, and in intestines, disease is also the source of ten thousand diseases; But along with the age is larger, profitable strain in enteron aisle (probio) ratio reduces gradually; As Bifidobacterium Bifidum accounts for 98% period infant, during to the middle age, be down to and only account for 5% in 10%, 65 years old later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies show that, normal flora has many irreplaceable effects in human body digestion, immunity and the aspect such as disease-resistant; The generation development of change and the various diseases, particularly intestines problem of gut flora composition is closely related, and finds from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one is intervened control method safely and effectively.
Contacting of intestinal microecology system and diabetes: type II diabetes (type 2 diabetes, T2D) be a kind of complicated endocrine system disease jointly being caused by h and E factor, prolonged illness can cause multiple system damages, be in a bad way or stress time can there is the acute metablize confusion, as DKA etc., its cause of disease and pathogenesis are more complicated, think at present genus polygenes, multifactorial different substantiality disease, human body intestinal canal microorganism is being brought into play significant role to maintaining human health, and in enteron aisle, keeping dynamic balance, and this balance is while causing gut flora to get muddled because some factor is broken, human body may will be suffered from various diseases, research discloses: the enteric microorganism flora imbalance of moderate has only appearred in patients with NIDDM, further functional analysis shows, some beneficial bacteriums in patients with NIDDM enteron aisle, are lost, some harmful bacterias increase to some extent on the contrary, such as, produce butyric acid bacteria reduces to some extent in patients with NIDDM, and the main adjustable human body intestinal canal microecological balance of butyric acid, intestinal health is played to critical effect, simultaneously, in the Chinese colony of the conditioned pathogen of some increases in this research, there is very much higher sample, in addition, microbial gene functional analysis also shows that oxidative pressure of intestinal environment etc. may exist certain relation with diabetes indirectly.
Though directly probiotic oral has certain effect, but because probio one cannot field planting in enteron aisle, and stop, occupy-place are little, easily run off, and withdraw rear harmful bacteria and easily recur, and associated patient needs long-term taking, and treatment cycle is long, often uses rear recurrence rate very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by the key technology research to probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts to seek to improve " medicine among integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can be played field planting effect, the enteron aisle adhesive capacity of the reduction of enteron aisle pH environment and raising probiotic cell etc., based on above-mentioned key element, suitable food materials screen from tens of kinds " medicines among integration of drinking and medicinal herbs " in this seminar, find first interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and jerusalem artichoke and stachyose, yeast, after Glu etc., external source probio is had to very strong field planting effect, for the prescription of probio in enteral microecological formulation selects to provide experimental basis.
Favourable is in the market primary raw material in order to eat source property small peptide, add the corn stigma of medicine-food two-purpose, sealwort, lily, the extract of the root of kudzu vine, B B-complex and mineral matter, composition compound prescription, utilize in addition the product that probio is primary raw material, but also do not find the constitutive character in conjunction with diabetic, according to the marrow theory of Traditional Chinese Medicine, vary with each individual, gold compatibility is with the Chinese medical extract elite of more than ten kinds medicine-food two-purpose, multiple probio, prebiotics is primary raw material, with small peptide, amino acid, water-soluble dietary fiber, B B-complex, the full nutrient formulation food that composite mineral matter auxiliary material is made, specific full nutrient formulation food or similar products.
goal of the invention
The object of the invention is inheriting on the theoretical treatment method of traditional Chinese medical science marrow, the initiative extract by multiple probio and " medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, water-soluble dietary fiber, B B-complex, composite mineral matter is auxiliary material, not only can supplement diabetic institute essential nutrients, improve body nutrition condition, can also and utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the full nutrient formulation food of the acceptable applicable patients with diabetes mellitus of people, specific full nutrient formulation food or non-full nutrient formulation food.
summary of the invention:
This R&D team is according to the requirement of " special medicine purposes formula food general rule ", in conjunction with diabetic's constitutive character, the achievements in research such as advanced physiology, medicine, nutrition and the clinical practice of comprehensive nowadays American Harvard University, the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of foundation " the middle residence that disappears is mended ", " equilibrium is taken good care of ", adopting Chinese medical extract elite, multiple probio, small peptide, the prebiotics of more than 10 kinds medicine-food two-purpose is primary raw material, with amino acid, water-soluble dietary fiber,
B B-complex, composite mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets diabetic, also have that nourishing blood and invigorating qi, the cool blood that detoxifies, relieving restlessness quench the thirst, nourishing hepatic yin, clearing lung-heat and prevent and treat the full nutrient formulation food of diabetes, specific full nutrient formulation food or non-full nutrient formulation food (compound prescription being combined into).
The main component of the present invention's formula is:
1. Chinese medical extract is that the liver,spleen,kidney three from theory of traditional Chinese medical science is dirty with being adjusted to main principle according to diabetic's constitutive character, utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to prevent and treat diabetes, and choose following several large class medicine and carry out compatibility; Wherein:
Cr-enriched yeast strengthens insulin active, controls blood sugar, can regulate fat stores amount, helps loss of weight.Reduce the content of blood cholesterol and triglycerides, prevention cardiovascular disease, the calorific value of stevioside is only 1/300 of sucrose, after taking in human body, be not absorbed, do not produce heat, diabetes and the applicable sweetener of obesity patient, the fermentation preparation of corn stigma has the reduction blood sugar effect of highly significant, sealwort has raising immunity of organisms, hypoglycemic, reducing blood lipid, antibacterial, antiviral, effect such as antitumor grade, Puerarin has hypoglycemic, expansion peripheral vascular, particularly coronary artery dilator blood vessel, suppress the effects such as platelet aggregation, thereby there are treatment diabetes, and improve peripheral nerve injury due to its microangiopathies and the effect of PVR and renal function pathology, in seed of bitter gourd, there is the protein similar with insulin, there is the hypoglycemic effect of falling,
2. many kinds of probios: make probio arrive enteron aisle by most of strong acid environment by stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote micro-absorption, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body field planting drag or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, can obviously reduce the level of intestinal endotoxemia the generation of preventing liver injury; It is also the important measures of adjusting intestinal microecology that selective enteron aisle decontamination is dyed, and has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by suppressing urease-producing in enteron aisle and producing the growth of ammonium bacteria, prevents and treats the generation of diabetes;
Multiple probio of the present invention refers to the Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum), lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus), streptococcus thermophilus four kinds of above or all mixing wherein.
3. small peptide: be oligopeptide, refer to the small molecule protein that utilizes bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need through digestion and directly absorb, bioavailability is high, in absorption and utilization, be better than free amino acid and complete protein, can be applicable in Protein intake food, especially for the low crowd of abilities of digestive and absorption, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function that improves small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,
Small peptide of the present invention refers to wherein a kind of, several or all mixing of marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide.
4. prebiotics: to urge the field planting of probio enteron aisle, enteron aisle convergence, to reduce enteron aisle pH environment, also do not utilized by most enteron aisle spoilage organisms, but can promote beneficial bacteria---the growth and breeding of lactobacillus, Bifidobacterium in human body, thereby can suppress spoilage organisms growth, contribute to improve and maintain enteron aisle normal function; Long-term edible can delay senility, defaecation, raising immunity, alleviate burden of liver, improve the absorptivity of nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, pH value in colon is reduced, the growth of inhibition harmful intestinal tract bacterium; Make Water-Electrolyte in small intestine be trapped in enteric cavity, produce the high effect of oozing, stimulate enterocinesia to cause laxative, thereby promote the discharge of intestinal endotoxin and other toxicants, lactulose also directly endotoxin in deactivation enteron aisle, reduce enteron aisle pH value, extensively model is applied to the treatment of diabetes;
Prebiotics of the present invention originally refers to one, several or all mixing wherein of oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide.
5. amino acid: being divided into essential amino acid and nonessential amino acid, is the base unit that forms protein, gives protein specific molecular morphosis, makes it have biochemical activity; Absorbing appropriate methionine contributes to the metabolism of various sulfur-containing compounds in human body and its contained methyl to methylate to Toxic or medicine and the effect of playing removing toxic substances; Leucine can be repaired muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress the growth of cancer knurl, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to the ammonia in blood change urea into and excrete out; For hyperammonemia, liver dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses alimentary canal nervous by vegetative nerve and that cause and festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improves sleep and regulates mood;
Amino acid of the present invention refers to one, several or all mixing wherein of methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine.
6. vitamin and mineral matter:
Vitamin and mineral matter are the nutrients of needed by human, and the vitamin adding in the present invention is that vitamin and mineral matter are the nutrients of needed by human;
The vitamin adding in the present invention is one, several or all mixing wherein of vitamin A, vitamin D, vitamin E, vitamin K, phytomenadione, vitamin C, vitamin B1, vitamin B2, pyridoxamine, cobalamin, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin;
The mineral matter adding in the present invention is one, several or all mixing wherein of calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;
In the present invention, the addition of vitamin and minerals is carried out with reference to GB14880 " food enrichment use sanitary standard ", GB2760 " food additives use standard ".
7. the present invention is dried and freeze drying integrated innovation with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, efficiently solves high temperature and the deactivation of strong acid gastric juice to probio in oral process; Adopt three layers of buried microcapsules technology of protein, extract with through biological enzymolysis or prehydrolysis SBE technology again and microencapsulation Chinese medical extract after treatment mixes, to solve the coexistence problems of " multiple probio " and " medicine among integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and arrive in enteron aisle and stop field planting by gastric juice smoothly by oral, make product prevent and treat diabetes effect and significantly improve compared with the like product of market;
8. adopt above-mentioned integrated innovation technique various batchings to be mixed to solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material to make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if making beverage saves spray-dried, add less black sesame powder etc., be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day was respectively drunk 1 bottle, and all operations all carries out in clean dried environment;
This characteristic of full nutrient formulation food and the effect of body is mainly manifested in to the following aspects of filling a prescription:
1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with diabetic's constitutive character, the achievement in research developments such as advanced physiology, medicine, nutrition and the clinical practice of comprehensive nowadays American Harvard University, vary with each individual, gold compatibility;
2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", adopting Chinese medical extract elite, multiple probio, the prebiotics of more than 10 kinds medicine-food two-purpose is primary raw material, with small peptide, amino acid, B B-complex, composite mineral matter auxiliary material, the organic assembling of various batchings, various functions are merged, and by the synergy between active ingredient, humidification effect;
3. there is efficient absorption, utilize formula of the present invention, various components adopt the food of suitable ratio collocation preparation, the state that oozes such as after a certain amount of water-soluble solution, be, can arrive small intestine by stomach fast, absorb fast, completely, can supplement rapidly diabetic's desired nutritional, do not increase liver kidney burden;
4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicines, contain several functions active component, not only improve the concentration of function factor, reduce the absorption of various impurity, contribute to alleviate liver kidney burden, there is the effect of resistance of human body of enhancing, have in addition nourishing blood and invigorating qi, the cool blood that detoxifies, relieving restlessness quench the thirst, nourishing hepatic yin, clearing lung-heat and prevent and treat diabetes and prevent and treat effects of diabetes;
5. contained probio in the present invention's formula, multiple probio can be safeguarded enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and the absorption of raising body to calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve the tolerance of host to radioactive ray, lactobacillus significantly increases intestinal mucosa immunoglobulin A (SIgA) content, body intestinal mucosa local immunity is had to regulating action, regulate stomach, the micro-ecology of intestines, can improve calcium, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, can also reduce the absorption of cholesterol,
6. formula food of the present invention is taking the food source inhibition biological active small peptide in multiple source as nitrogenous source, because small peptide does not need digestion to absorb, more be conducive to the utilization of body, can effectively improve diabetic's negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, the absorbability of raising intestinal mucosa;
7. this prescription adopts Liao Ben team by the achievement of the key technology research to probio field planting mechanism in enteron aisle over nearly 3 year, improve " medicine among integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence that combines prebiotics can be played the key element such as the reduction of field planting effect, enteron aisle pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula has strengthened the field planting effect to external source probio greatly;
8. contained prebiotics in the present invention's formula, by promoting the growth and breeding of probio in intestines, suppress the growth of spoilage organisms, form one protective barrier on intestinal mucosa surface simultaneously, can resist the damage of enteron aisle spoilage organisms to intestinal mucosa, reduce the absorption of intestinal toxic material, can also promote intestines peristalsis, accelerate the discharge of residuals in intestines, can prevent constipation, and also can strengthen immunity of organisms by the growth and breeding that promotes beneficial bacteria of intestinal tract, the bioactivators such as small peptide and active polysaccharide have synergy;
9, contained amino acid in the present invention's formula, it is the base unit that forms protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compounds in human body and its contained methyl to methylate to Toxic or medicine and play the effect of removing toxic substances, can repair muscle, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development;
10, formula food of the present invention containing multivitamin and mineral matter, can supplement rapidly the required micronutrient of diabetic, small peptide by with the chelating of calcium, iron, zinc etc. after, more increased the absorptivity of mineral matter element;
11, not fatty and cholesterol in the present invention's formula, can, in supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, has avoided the adverse effect of the high protein diet such as meat, egg.
Detailed description of the invention
Below by following examples, the invention will be further described, and it will contribute to understand the present invention.
Embodiment mono-
Case study on implementation one is realized the full nutrient formulation food of the object of the invention diabetes, and it comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 12g, sealwort 11g, lily 11g, root of kudzu vine 10g, balsam pear 10g, cassia seed 9g, Sessileflower Acanthopanax Bark 9g, dark plum 9g, Radix Glycyrrhizae 9g, Cr-enriched yeast powder 8g, steviol glycoside 8g, fruit of Chinese magnoliavine 7g, wind-weed 7g, Radix Codonopsis 7g, Radix Astragali 7g, the tuber of dwarf lilyturf 6g, barley seedling 6g, hawthorn 6g, roselle 6g, Chinese yam 5g, semen litchi 5g, konjaku 5g, sea-buckthorn 5g, black fungus 5g, algae extrats 5g, maize oligopeptide powder 4g, ground dragon protein 4g, wheat oligopeptide 4g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 200g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 150g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 100g, water-soluble dietary fiber 50g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, phytomenadione 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g, first will be being to add cycloheptaamylose after corn stigma, sealwort, lily, the root of kudzu vine, balsam pear, cassia seed, Sessileflower Acanthopanax Bark, dark plum, Radix Glycyrrhizae, the fruit of Chinese magnoliavine, the wind-weed, Radix Codonopsis, the Radix Astragali, the tuber of dwarf lilyturf, barley seedling, hawthorn, roselle, Chinese yam, semen litchi, konjaku, sea-buckthorn soak when making, after extracting by prehydrolysis SBE technology, spray-dried and the flour of preparation, then add small peptide, prebiotics, amino acid, Cr-enriched yeast powder, steviol glycoside, water-soluble dietary fiber, black fungus that biological enzymolysis extracts,
Algae extrats, maize oligopeptide powder, ground dragon protein, wheat oligopeptide, multivitamin and mineral matter carry out pasteurization 1 hour after mixing, then add the Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum), lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus), streptococcus thermophilus the various batchings of mixing mix the solid beverage of making powdery, granule, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material to make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if making beverage saves spray-dried, add less black sesame powder etc., be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day was respectively drunk 1 bottle, and all operations all carries out in clean dried environment.
Embodiment bis-
The full nutrient formulation food of above-mentioned diabetes also comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 16g, sealwort 14g, lily 14g, root of kudzu vine 13g, balsam pear 13g, cassia seed 12g, Radix Glycyrrhizae 11g, barley seedling 11g, hawthorn 10g, roselle 10g, Chinese yam 9g, semen litchi 9g, konjaku 9g, sea-buckthorn 8g, black fungus 8g, dark plum 7g, algae extrats 7g, maize oligopeptide powder 7g, ground dragon protein 6g, wheat oligopeptide 6g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 200g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 150g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 100g, water-soluble dietary fiber 50g, vitamin A 0.01g, vitamin D 0.000015 g, vitamin E 0.12g, vitamin K 0.0075 g, phytomenadione 0.00001 g, vitamin C 1 0.625g, vitamin B1 0.016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15 g, zinc 6.2g, selenium 0.00012 g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.
Embodiment tri-
The full nutrient formulation food of above-mentioned diabetes also comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 17g, sealwort 16g, root of kudzu vine 15g, balsam pear 15g, cassia seed 14g, barley seedling 14g, hawthorn 13g, roselle 13g, Chinese yam 12g, semen litchi 11g, konjaku 11g, sea-buckthorn 11g, algae extrats 10g, maize oligopeptide powder 10g, ground dragon protein 9g, wheat oligopeptide 9g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 200g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 150g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 100g, water-soluble dietary fiber 50g, vitamin A 0.01g, vitamin D 0.000015 g, vitamin E 0.12g, vitamin K 0.0075 g, phytomenadione 0.00001 g, vitamin C 1 0.625g, vitamin B1 0.016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15 g, zinc 6.2g, selenium 0.00012 g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.
Embodiment tetra-
The full nutrient formulation food of above-mentioned diabetes also comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 17g, sealwort 17g, root of kudzu vine 16g, balsam pear 16g, cassia seed 15g, barley seedling 15g, hawthorn 14g, roselle 14g, Chinese yam 14g, sea-buckthorn 13g, algae extrats 13g, maize oligopeptide powder 12g, earthworm protein 12 g, wheat oligopeptide 12g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 200g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 150g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 100g, water-soluble dietary fiber 50g, vitamin A 0.01g, vitamin D 0.000015 g, vitamin E 0.12g, vitamin K 0.0075 g, phytomenadione 0.00001 g, vitamin C 1 0.625g, vitamin B1 0.016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15 g, zinc 6.2g, selenium 0.00012 g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.
Embodiment five
The full nutrient formulation food of above-mentioned diabetes also comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 24g, sealwort 22g, root of kudzu vine 20g, balsam pear 18g, cassia seed 17g, barley seedling 16g, hawthorn 16g, roselle 15g, algae extrats 14g, maize oligopeptide powder 14g, earthworm protein 12 g, wheat oligopeptide 12g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 200g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 150g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 100g, water-soluble dietary fiber 50g, vitamin A 0.01g, vitamin D 0.000015 g, vitamin E 0.12g, vitamin K 0.0075 g, vitamin C 1 0.625g, vitamin B1 0.016g, vitamin B2 0.016g, pyridoxamine 0.015g, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15 g, zinc 6.2g, selenium 0.00012 g, copper 0.007g, manganese 0.018g.
Embodiment six
The full nutrient formulation food of above-mentioned diabetes also comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 26g, sealwort 24g, root of kudzu vine 22g, balsam pear 20g, cassia seed 18g, barley seedling 18g, hawthorn 16g, roselle 16g, maize oligopeptide powder 14g, earthworm protein 14 g, wheat oligopeptide 12g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 250g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 150g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 100g, water-soluble dietary fiber 50g.
Embodiment seven
The full nutrient formulation food of above-mentioned diabetes also comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 30g, sealwort 26g, root of kudzu vine 24g, balsam pear 24g, cassia seed 22g, barley seedling 20g, hawthorn 20g, roselle 18g, wheat oligopeptide 16g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 250g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 150g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 100g, water-soluble dietary fiber 50g.
Embodiment eight
The full nutrient formulation food of above-mentioned diabetes also comprises following component by weight: the extract of medicine-food two-purpose: corn stigma 32g, sealwort 31g, root of kudzu vine 30g, balsam pear 29g, cassia seed 28g, hawthorn 26g, wheat oligopeptide 24g, Bifidobacterium (bifidobacterium adolescentis after microencapsulation, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum) 100g, lactobacillus (lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, breast subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus) 100g, streptococcus thermophilus 50g, small peptide (marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide) 250g, prebiotics (oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide) 200g, compound amino acid ((methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine) 200g, water-soluble dietary fiber 50g.
The present invention is dried and freeze drying integrated innovation with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, efficiently solves high temperature and the deactivation of strong acid gastric juice to probio in oral process; Adopt three layers of buried microcapsules technology of protein, extract with through biological enzymolysis or prehydrolysis SBE technology again and microencapsulation Chinese medical extract after treatment mixes, to solve the coexistence problems of " multiple probio " and " medicine among integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and arrive in enteron aisle and stop field planting by gastric juice smoothly by oral, make product prevent and treat diabetes effect and significantly improve compared with the like product of market.