CN104839684A - Medical formula food for people with helicobacter pylori related gastritis - Google Patents

Abstract

The invention belongs to the technical field of medicine and food homology formula and new resource food, and more specifically provides a medical formula food, a specific medical formula food, or an unspecified medical formula food for patients with helicobacter pylori related gastritis. The medical formula food is prepared based on requirements of <special medical formula food general principles>, via combination with physical characteristics of patients with helicobacter pylori related gastritis, via combination of a plurality of traditional Chinese medicine raw materials which can be taken as both medicines and food based on traditional Chinese medicine quintessence theories; and is prepared via mixing of a plurality of traditional Chinese medicine extract essence; a plurality of microencapsulated probiotics; oligopeptides, prebiotics, amino acids, and carbohydrates obtained via biological enzymolysis extraction; grease with healthcare functions; and a plurality of vitamins and mineral matters. The traditional Chinese medicine extract essence is obtained via prehydrolysis SBE technology from traditional Chinese medicine raw materials which can be taken as both medicines and food. The medical formula food can be taken as a signal nutrition source so as to satisfy nutrient requirements of patients with helicobacter pylori related gastritis, and is capable of clearing away heat and drying dampness, invigorating blood circulation and dispersing blood stasis, tonifying spleen and promoting appetite, promoting digestion to eliminate stagnation, warming stomach for dispelling cold, cooling blood to relieve pain, and improving immunity.

Description

Hp-relative Gastritis medical science formula food

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and new resource food technical field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds with small peptide, prebiotics, amino acid, carbohydrate, the medical science formula food of eradicate helicobacter pylori having the grease of health care, B B-complex, composite mineral matter to make for auxiliary material, certain medical formula food or non-medical formula food.

Background technology

Helicobacter pylori, Helicobacter pylori, be called for short Hp, 1893, Italy's virologist Bizzozero first report finds spirality microorganism in mammal stomach, nineteen eighty-two, Western Australia Pathologis Warren finds 135 routine curved and S shape bacteriums, result is published on famous magazine " lancet " with letter form, nineteen eighty-two, Australia scholar Marshall is observed in stomach lining has one to make the bacterium of helicobacter pylori (being called for short HP) fall ill relevant with chronic gastropathy, helicobacter pylori is a kind of one pole, many flagellums, the blunt circle of end, the bacterium of helically bent, long 2.5 ~ 4.0 μm, wide 0.5 ~ 1.0 μm, normal in typical helical form or arc on gastric epithelial cell surface, when cultured on solid medium, except typical form, sometimes shaft-like or spherical shape can be there is, helicobacter pylori is microaerobion, ambient oxygen requires 5 ~ 8%, can not grow under air or absolute anaerobic environment, helicobacter pylori is the mankind unique a kind of known stomach bacteriums so far, the helicobacter of other kinds also finds in fraction of mammalian cells and bird body, long-term ulcer, cancer can be caused, therefore WHO announces that stomach helicobacter pylori infection is the carcinogen of microbiocidal, also be first can be carcinogenic prokaryotes, helicobacter pylori infections is chronic active gastritis, peptic ulcer, the main pathogenic of gastric mucosa-associated lymphoid tissue (MALT) lymthoma and cancer of the stomach, infect helicobacter pylori and can cause chronic gastritis and intestine gastric ulcer disease, large quantity research shows, duodenal ulcer more than 90% and the gastric ulcer of about 80%, all caused by helicobacter pylori infections, at present, Gastroenterology dept. doctor can by the diagnosing helicobacter pylori infection such as endoscopy and breath test, antibiotic methods for the treatment of has been proved to be able to the diseases such as radical cure gastric ulcer, the discovery of helicobacter pylori and effect thereof, break at that time popular people for many years to the wrong understanding of gastritis and peptic ulcer mechanism, being described as is the landmark revolution of disease for digest research field,

" integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science; The traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet; Allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery;

For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard traditional Chinese medicine food clear stipulaties: 2.1.1 medical science formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 certain medical formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition;

Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively.

Though direct probiotic oral has certain effect, but due to probio one cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by the key technology research to probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and inulin and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis,

Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort etc., B B-complex and mineral matter composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character combining the patient infecting helicobacter pylori, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, there is the grease of health care, amino acid, multivitamin, several mineral materials is the medical science formula food that auxiliary material is made, certain medical formula food or similar products.

goal of the invention

The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative probio of Intestinal Mucosal Injury in Patients Undergoing Tiny ecosystem multiple improvement being infected helicobacter pylori combines with the extract of " Chinese medicine of integration of drinking and medicinal herbs " compound, add with small peptide, amino acid, carbohydrate, there is the grease of health care, multivitamin, several mineral materials is auxiliary material, the patient institute essential nutrients of the eradicate helicobacter pylori of hypoimmunity can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the medical science formula food of the edible for patients of the acceptable applicable infection helicobacter pylori of people, certain medical formula food or non-medical formula food.

summary of the invention:

This R&D team is according to the requirement of " special medicine purposes formula food general rule ", in conjunction with the constitutive character of the patient of infection helicobacter pylori, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt Chinese medical extract elite and the new resource food of one or more medicine-food two-purposes, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, there is the grease of health care, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets the patient of eradicate helicobacter pylori, also has heat-clearing and damp-drying drug, promoting blood circulation to remove blood stasis, spleen benefiting and stimulating the appetite, relieving dyspepsia, warming stomach for dispelling cold, the medical science formula food of effect of cooling blood and relieving pain and develop immunitypty, certain medical formula food or non-medical formula food (compound prescription be combined into),

1, the main component of the present invention's formula is:

Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to the constitutive character of the patient infecting helicobacter pylori, utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to build up resistance, and choose following several large class medicine and carry out compatibility; Wherein: the coptis, there is heat-clearing and damp-drying drug, effect of purging intense heat and detonicating; Rheum officinale, has and attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, effect such as the stasis of blood, removing toxic substances of dispelling; Rhizoma atractylodis, invigorating the spleen, eliminating dampness, Xie Yu, wards off dirty; The root of large-flowered skullcap, has heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, the effect such as antiabortive; Golden cypress, heat-clearing and damp-drying drug, purging intense heat removes steams, detoxification sore treatment; Kuh-seng, heat-clearing and damp-drying drug, desinsection, diuresis; Chinese violet, has clearing heat and detoxicating effect; The radix paeoniae rubrathe, function: the row stasis of blood, pain relieving, cool blood, detumescence; Curcuma zedoary can control promoting qi circulation and relieving pain, long-pending dissipating bind, dissipating blood stasis with potent drugs effect; Profound Hu, promoting blood circulation to remove blood stasis, promoting qi circulation and relieving pain; Verbena officinalis, have cool blood, the loose stasis of blood, stimulate the menstrual flow, heat-clearing, removing toxic substances, antipruritic, expelling parasite, dissipate-swelling effect; Giant knotweed, invigorate blood circulation, the loose stasis of blood, stimulate the menstrual flow, the effect such as antibechic; Radix scrophulariae, clearing heat and cooling blood; Nourishing Yin and falling fire; Detoxicating and resolving a mass; Cassia twig, has effect of complement sun, promoting blood circulation, warming spleen and stomach; Radix bupleuri, in having and inducing sweat, soothing the liver, rise effect of sun; Rose, sharp gas, promoting circulation of blood, control wandering arthritis, loose tired pain relieving; Smilax, dampness removing thermal detoxification, strengthening the spleen and stomach; Hawthorn is the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting; Galangal, warming stomach for dispelling cold, help digestion pain relieving; Dark plum, astringes the lung, and puckery intestines, promote the production of body fluid, claming ascaris; Honeysuckle, property sweet cold air fragrance, clear heat with drugs of sweet flavour and cold nature and not injuring one's stomach;

Medicinal and edible Chinese medicine extract of the present invention refers to the coptis, rheum officinale, rhizoma atractylodis, the root of large-flowered skullcap, golden cypress, kuh-seng, Chinese violet, the radix paeoniae rubrathe, curcuma zedoary, profound Hu, Verbena officinalis, giant knotweed, radix scrophulariae, cassia twig, radix bupleuri, the Radix Astragali, evodia rutaecarpa, Herba Andrographitis, isatis root, indigo naturalis, myrobalan, corydalis tuber, the bark of ash, rose, smilax, hawthorn, galangal, dark plum, honeysuckle, gingko, cordate houttuynia, dandelion, chrysanthemum, balloonflower root, Radix Glycyrrhizae, ginseng, Hericium erinaceus, sea-buckthorn, the membrane of a chicken's gizzard, papaya, radish seed, Fructus Hordei Germinatus, circle luxuriant isapgol husk, buzhaye, cynanchum auriculatum Royle, breast mineral saltone, several or whole, adopt biological enzymolysis or prehydrolysis SBE to extract and microencapsulation, the mixture after spray-dried and cryodesiccated extract,

2, multiple probio: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by urease-producing in suppression enteron aisle and the growth of producing ammonium bacteria, builds up resistance;

Multiple probio of the present invention all adopts the probio after microencapsulation, and the probio described in it is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici are wherein a kind of, several or all mix;

Bifidobacterium above a refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above b refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri;

3, small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,

Small peptide of the present invention refers to that maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix;

4, prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, enterocinesia is stimulated to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of the resistance of enhancing eradicate helicobacter pylori;

Prebiotics of the present invention is 2 classes

A. have very strong field planting effect prebiotics to external source probio: Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin extract;

B. common prebiotics: oligoisomaltose, FOS, trehalose, soyabean oligosaccharides, xylo-oligosaccharide, cotton seed compound sugar, stachyose, yeast;

Prebiotics of the present invention is: the extract of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, stachyose, yeast, oligoisomaltose, trehalose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix;

5, carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

Carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, galactolipin, lactose, glucose, maltose, carbohydrate, has the grease of health care, starch, glycogen one wherein, several or all mix;

6. there is the grease of health care to refer to there is health-care effect to the person, and finished product energy can be increased, make the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal); As the street cleaner that fish oil is human vas, can also prevention of arterial sclerosis, apoplexy and heart disease.Fish oil is the diseases such as hypertension, coronary heart disease, headstroke, diabetes, rheumatic arthritis, cancer; Linseed oil has fat-reducing, reduces cholesterol, improves the effects such as renal function; Peony seed oil has reducing blood lipid and hypotensive, strengthens autoimmunity, prevention diabetes, effect of anti-curing cancers; Samara oil prevents and treats hypertension, high fat of blood, effect of the illnesss such as vascular sclerosis;

Of the present invention have the grease of health care to refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix,

7. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;

Amino acid of the present invention refers to Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix;

8. vitamin and mineral matter: vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;

The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;

In the present invention, the addition of vitamin and minerals performs with reference to " special medicine purposes formula food general rule ", now for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

The present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat eradicate helicobacter pylori significantly improves compared with the like product of market;

9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

The characteristic of this formula medical science formula food and the following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of the patient of eradicate helicobacter pylori, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility;

2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is adopted to be primary raw material, with prebiotics, carbohydrate, the grease having health care, amino acid, multivitamin and mineral matter for auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect;

3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb fast, completely, the patient's desired nutritional infecting helicobacter pylori can be supplemented rapidly;

4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, there is the effect strengthening resistance of human body, also have effect of heat-clearing and damp-drying drug, promoting blood circulation to remove blood stasis, spleen benefiting and stimulating the appetite, relieving dyspepsia, warming stomach for dispelling cold, cooling blood and relieving pain and develop immunitypty;

5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced,

6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, effectively can improve the patient's negative nitrogen balance infecting helicobacter pylori, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa;

7. this prescription have employed this team by the achievement to probio key technology research of field planting mechanism in enteron aisle over nearly 3 year, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio;

8. prebiotics contained in the present invention's formula, by promoting the growth and breeding of probio in intestines, suppress the growth of spoilage organisms, form one protective barrier at intestinal mucosal surface simultaneously, the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted, reduce the absorption of intestinal toxic material, intestines peristalsis can also be promoted, accelerate the discharge of residuals in intestines, constipation can be prevented, and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivators such as small peptide, carbohydrate and active polysaccharide have synergy;

9, in the present invention's formula, contained carbohydrate is for human body provides three of heat energy kinds of main nutrients, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) that conveys hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce;

10. in the present invention's formula, the contained grease of health care that has not only has health-care effect to the person, and provides the energy needed for normal life for human body, makes the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal);

Amino acid contained in 11. the present invention's formulas, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development;

12. formula foods of the present invention containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for Hp-relative Gastritis patient, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element;

Not fatty and cholesterol in 13. the present invention's formulas, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.

Detailed description of the invention

Below by following case study on implementation, the invention will be further described, and it will contribute to understanding the present invention.

Case study on implementation one

Realize the object of the invention hp-relative Gastritismedical science formula food be combine the constitutive character of patient infecting helicobacter pylori, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease of health care, multivitamin, several mineral materials to make for auxiliary material;

Fill a prescription by following raw materials according and consumption thereof, the extract of medicine-food two-purpose and new resource food: coptis 8g, rheum officinale 8g, rhizoma atractylodis 8g, root of large-flowered skullcap 8g, golden cypress 7g, kuh-seng 7g, Chinese violet 7g, radix paeoniae rubrathe 7g, curcuma zedoary 7g, profound Hu 7g, Verbena officinalis 6g, giant knotweed 6g, radix scrophulariae 6g, cassia twig 6g, radix bupleuri 6g, Radix Astragali 6g, evodia rutaecarpa 5g, Herba Andrographitis 5g, isatis root 5g, indigo naturalis 5g, myrobalan 5g, corydalis tuber 5g, bark of ash 5g, rose 4g, smilax 4g, hawthorn 4g, galangal 4g, dark plum 3g, honeysuckle 3g, gingko 3g, cordate houttuynia 3g, dandelion 3g, chrysanthemum 3g, balloonflower root 2g, dried orange peel 2g, Radix Glycyrrhizae 2g, ginseng 2g, Hericium erinaceus 2g, sea-buckthorn 2g, the membrane of a chicken's gizzard 2g, papaya 2g, radish seed 2g, Fructus Hordei Germinatus 2g, the luxuriant isapgol husk of circle1g , buzhaye1g , cynanchum auriculatum Royle1g, breast mineral salt1g, multiple probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, there is the grease 100g of health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

During making first will be the coptis, rheum officinale, rhizoma atractylodis, the root of large-flowered skullcap, golden cypress, kuh-seng, Chinese violet, the radix paeoniae rubrathe, curcuma zedoary, profound Hu, Verbena officinalis, giant knotweed, radix scrophulariae, cassia twig, radix bupleuri, the Radix Astragali, evodia rutaecarpa, Herba Andrographitis, isatis root, indigo naturalis, myrobalan, corydalis tuber, the bark of ash, rose, smilax, hawthorn, galangal, dark plum, honeysuckle, gingko, cordate houttuynia, dandelion, chrysanthemum, balloonflower root, Radix Glycyrrhizae, ginseng, Hericium erinaceus, sea-buckthorn, the membrane of a chicken's gizzard, papaya, radish seed, Fructus Hordei Germinatus, circle luxuriant isapgol husk, buzhaye, cynanchum auriculatum Royleadd cycloheptaamylose after immersion, with prehydrolysis SBE technology extract after, spray-dried and preparation flour, then add biological enzymolysis extract small peptide, prebiotics, amino acid, breast mineral salt,carbohydrate, have the grease of health care, multivitamin and mineral matter to be pulverized and mixed together after carry out pasteurization 1 hour, then the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus mix solid beverage, the granule of making powdery is added, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

Manufacture craft of the present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat Hp-relative Gastritis significantly improves compared with the like product of market.

Case study on implementation two

Above-mentioned hp-relative Gastritismedical science formula food also comprises following component by weight, the extract of medicine-food two-purpose:, rose 4g, smilax 4g, hawthorn 4g, galangal 4g, dark plum 3g, honeysuckle 3g, gingko 3g, cordate houttuynia 3g, dandelion 3g, chrysanthemum 3g, balloonflower root 2g, Radix Glycyrrhizae 2g, ginseng 2g, Hericium erinaceus 2g, sea-buckthorn 2g, the membrane of a chicken's gizzard 2g, papaya 2g, radish seed 2g, Fructus Hordei Germinatus 2g, the luxuriant isapgol husk of circle1g , buzhaye1g , cynanchum auriculatum Royle1g, breast mineral salt1g, prebiotics 350g, probio 300g, small peptide 150g, several amino acids 100g, carbohydrate 100g, the grease 100g having health care, carbohydrate, the grease having health care, 50g, vitamin and mineral matter 25g.

Case study on implementation three

Above-mentioned hp-relative Gastritismedical science formula food also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation four

The certain medical formula food of above-mentioned Hp-relative Gastritis also comprises following component by weight: prebiotics 700g, small peptide 500g, carbohydrate 300g, multiple probio 300g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation five

Above-mentioned Hp-relative Gastritis medical science formula food also comprises following component by weight: prebiotics 500g, small peptide 350g, carbohydrate 300g, multiple probio 250g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation six

Above-mentioned Hp-relative Gastritis medical science formula food also comprises following component by weight: small peptide 350g, prebiotics 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Claims (10)

1. Hp-relative Gastritis medical science formula food, it is characterized in that combining the constitutive character infecting helicobacter pylori patient, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease of health care, multivitamin, several mineral materials to make for auxiliary material;

Fill a prescription by following raw materials according and consumption thereof, the extract of medicine-food two-purpose and new resource food: coptis 8g, rheum officinale 8g, rhizoma atractylodis 8g, root of large-flowered skullcap 8g, golden cypress 7g, kuh-seng 7g, Chinese violet 7g, radix paeoniae rubrathe 7g, curcuma zedoary 7g, profound Hu 7g, Verbena officinalis 6g, giant knotweed 6g, radix scrophulariae 6g, cassia twig 6g, radix bupleuri 6g, Radix Astragali 6g, evodia rutaecarpa 5g, Herba Andrographitis 5g, isatis root 5g, indigo naturalis 5g, myrobalan 5g, corydalis tuber 5g, bark of ash 5g, rose 4g, smilax 4g, hawthorn 4g, galangal 4g, dark plum 3g, honeysuckle 3g, gingko 3g, cordate houttuynia 3g, dandelion 3g, chrysanthemum 3g, balloonflower root 2g, dried orange peel 2g, Radix Glycyrrhizae 2g, ginseng 2g, Hericium erinaceus 2g, sea-buckthorn 2g, the membrane of a chicken's gizzard 2g, papaya 2g, radish seed 2g, Fructus Hordei Germinatus 2g, the luxuriant isapgol husk of circle1g , buzhaye1g , cynanchum auriculatum Royle1g, breast mineral salt1g, multiple probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, there is the grease 100g of health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

During making first will be the coptis, rheum officinale, rhizoma atractylodis, the root of large-flowered skullcap, golden cypress, kuh-seng, Chinese violet, the radix paeoniae rubrathe, curcuma zedoary, profound Hu, Verbena officinalis, giant knotweed, radix scrophulariae, cassia twig, radix bupleuri, the Radix Astragali, evodia rutaecarpa, Herba Andrographitis, isatis root, indigo naturalis, myrobalan, corydalis tuber, the bark of ash, rose, smilax, hawthorn, galangal, dark plum, honeysuckle, gingko, cordate houttuynia, dandelion, chrysanthemum, balloonflower root, Radix Glycyrrhizae, ginseng, Hericium erinaceus, sea-buckthorn, the membrane of a chicken's gizzard, papaya, radish seed, Fructus Hordei Germinatus, circle luxuriant isapgol husk, buzhaye, cynanchum auriculatum Royleadd cycloheptaamylose after immersion, with prehydrolysis SBE technology extract after, spray-dried and preparation flour, then add biological enzymolysis extract small peptide, prebiotics, amino acid, breast mineral salt,carbohydrate, have the grease of health care, multivitamin and mineral matter to be pulverized and mixed together after carry out pasteurization 1 hour, then the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus mix solid beverage, the granule of making powdery is added, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

Manufacture craft of the present invention is characterized in that with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat Hp-relative Gastritis significantly improves compared with the like product of market.

2. Hp-relative Gastritis medical science formula food according to claim 1, it is characterized in that described medicine-food two-purpose Chinese herbal medicine extract and new resource food are: the coptis, rheum officinale, rhizoma atractylodis, the root of large-flowered skullcap, golden cypress, kuh-seng, Chinese violet, the radix paeoniae rubrathe, curcuma zedoary, profound Hu, Verbena officinalis, giant knotweed, radix scrophulariae, cassia twig, radix bupleuri, the Radix Astragali, evodia rutaecarpa, Herba Andrographitis, isatis root, indigo naturalis, myrobalan, corydalis tuber, the bark of ash, rose, smilax, hawthorn, galangal, dark plum, honeysuckle, gingko, cordate houttuynia, dandelion, chrysanthemum, balloonflower root, Radix Glycyrrhizae, ginseng, Hericium erinaceus, sea-buckthorn, the membrane of a chicken's gizzard, papaya, radish seed, Fructus Hordei Germinatus, circle luxuriant isapgol husk, buzhaye, cynanchum auriculatum Royle, breast mineral salt whereinone, several or all mix.

3. Hp-relative Gastritis medical science formula food according to claim 1, is characterised in that and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food according to described formula mixing.

4. Hp-relative Gastritis medical science formula food according to claim 1, also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295 kJ (70 kcal).

5. Hp-relative Gastritis medical science formula food according to claim 1, is characterized in that described probio is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici, wherein a kind of, several or all mix;

Bifidobacterium above refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri.

6. Hp-relative Gastritis medical science formula food according to claim 1, it is characterized in that described prebiotics is: the extraction mixture of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, trehalose, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix.

7. Hp-relative Gastritis medical science formula food according to claim 1, is characterized in that described amino acid is: Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

8. the medical science formula food of Hp-relative Gastritis according to claim 1, is characterized in that described carbohydrate is that carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

9. Hp-relative Gastritis medical science formula food according to claim 1, it is characterized in that the described grease of health care that has is: refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix.

10. Hp-relative Gastritis medical science formula food according to claim 1, is characterized in that described small peptide is: marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix.