CN104839656A - Liver disease medicine formula food - Google Patents

Abstract

The present invention belongs to the technology field of medicinal and edible formula and new resource food, and specifically provides medicine formula food, specific medical formula food or non-specific medical formula food for patients with liver disease to eat; according to the requirement of "General principles of formula food for special medical purposes", combining the physical characteristics of patients with liver disease, and according to the essence theory of traditional Chinese medical science, the formula food is prepared by mixing a reasonable compatibility of a variety of "medicinal and edible" traditional Chinese medicines, a variety of SBE pre-hydrolysis technology extracted medicinal and edible traditional Chinese medicine essences, various microencapsulated probiotic bacteria, biological enzymolysis extracted short chain polypeptides, prebiotics, amino acids, carbohydrates, health-care functional lipa, and various vitamins and minerals, and other processes. The formula food not only can act as a single source of nutrition to meet the nutritional requirements of patients with liver disease, but also can play roles in nourishing liver, clearing away heat and toxic material, invigorating blood circulation to dissipate blood stasis, regulating the function of the liver and spleen, regulating qi to remove stasis, calming the adverse-rising energy and arresting vomiting, and preventing and treating of the liver disease.

Description

Hepatopathy medical science formula food

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and new resource food technical field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds with small peptide, prebiotics, amino acid, carbohydrate, the anti-hepatic medical science formula food, certain medical formula food or the non-medical formula food that have the grease of health care, B B-complex, composite mineral matter to make for auxiliary material.

Background technology

The cause of hepatitis is: the factor in 1 external world comprises and infects virus, and have the malicious or scorching poison of viral hepatitis type E of the scorching poison of hepatitis A, b hepatitis, from extraneous intrusive body, this is the external paathogenic factor of modal one; 2 other inappropriate medications, the metabolic organ of liver also will come to harm; As the saying goes " being medicine three points of poison ", the medicine eaten too much, too assorted, dosage large, and liver be can't stand and also can be caused inflammation; Also have picture to drink, a large amount of drinks, long-term excessive drinking, and liver equally also can come to harm; 3 self livers also can cause the inflammation of liver due to the disorder of immunity, so inside and outside two kinds of factors can cause the inflammation of liver organization, form hepatitis; These inflammation are constant, and these factor of damages delay to reject, and slowly develop, liver fibrosis of arriving, finally develops into cirrhosis, even canceration; " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science; The traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet; Allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery;

For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard traditional Chinese medicine food clear stipulaties: 2.1.1 medical science formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 certain medical formula food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition;

Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively.

Contacting of intestinal microecology system and liver: liver is the maximum glandular organ of human body, the blood of 80% supplies from portal vein, portal vein is rich in the various nutriments from intestinal absorption, simultaneously also containing the various metabolites that enteric bacteria produces, the gut derived exndotoxin of trace and the bacterium of enteron aisle transposition, the multiple biological function of liver all has close contacting with gut flora, the conjugated bile acids of hepatic secretion has inhibitory action the foreign nationality bacterium (pathogenic bacteria) of small intestine to enteron aisle on the one hand, sequestered bile acid in large intestine by adjust ph and regulating intestinal canal colony balance, the metabolite of gut flora is to the fat of liver on the other hand, protein, sugar, vitamin, the metabolic processes such as hormone have important regulating action, the acidic metabolite of Bifidobacterium etc. is if acetic acid, butyric acid etc. are by the energetic supersession of the transformation participation host of liver, intestinal beneficial bacterium also can reduce by its acidic metabolite the growth that enteron aisle produces ammonia, urease-producing bacterium, and ammonia can be utilized as nitrogenous source synthetic protein, alleviates the removing toxic substances load of liver, in addition, a large amount of proinflammatory cytokines, the gut derived exndotoxin of intestine immunity reaction release can enter liver by portal vein, activate Liver immunity cell as Kupffer cell etc., discharge a series of inflammatory mediator, further intestinal mucosa and remote organization's organ are impacted, as can be seen here, the various biological function of liver and the normal micro-ecological environment of enteron aisle have close contacting.

Though direct probiotic oral has certain effect, but due to probio cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by the key technology research to probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and inulin and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis,

Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort, B B-complex and mineral matter, composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character in conjunction with hepatopath, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of more than ten kinds medicine-food two-purposes, multiple probio, prebiotics is primary raw material, with small peptide, amino acid, carbohydrate, there is the grease of health care, B B-complex, the medical science formula food that composite mineral matter auxiliary material is made, certain medical formula food or similar products.

goal of the invention

The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative extract by multiple anti-hepatitis probio and " Chinese medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, carbohydrate, there is the grease of health care, B B-complex, composite mineral matter is auxiliary material, hepatopath institute essential nutrients can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the medical science formula food that the acceptable applicable hepatopath of people eats, certain medical formula food or non-medical formula food.

summary of the invention:

This R&D team is according to the requirement of " special medicine purposes formula food general rule ", in conjunction with the constitutive character of hepatopath, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt Chinese medical extract elite and the new resource food of one or more medicine-food two-purposes, multiple probio, small peptide, prebiotics is primary raw material, with amino acid, carbohydrate, there is the grease of health care, B B-complex, composite mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets hepatopath, also has nourishing liver liver, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, regulating the function of the liver and spleen, regulating the flow of vital energy is turbid, stopping nausea and vomiting by lowering the adverse flow of QI and anti-hepatic medical science formula food, certain medical formula food or non-medical formula food (compound prescription be combined into),

1. the main component of the present invention's formula is:

Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to the constitutive character of hepatopath, utilizes the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to prevent and treat hepatopathy, and chooses following several large class medicine and carry out compatibility; Wherein: nourishing liver and kidney: Cordyceps sinensis, Cordyceps militaris, the stem of noble dendrobium, glossy ganoderma, sealwort, propolis, the fruit of Chinese wolfberry, dark plum; Clearing heat and detoxicating: cape jasmine, dandelion, purslane, hoveniae semoveniae semen, cassia seed, Semen sesami nigrum, black soya bean; Soothing liver and strengthening spleen: rice sprout, Fructus Hordei Germinatus, hawthorn, the root of kudzu vine, peppermint, Buddha's hand, coix seed, Poria cocos, Chinese yam, Gorgon fruit, lotus seeds; Dispersing stagnated hepatoqi: FLOS CHRYSANTHEMI ALBA from Haizhou of China, Flos Magnoliae Officinalis, flower bud of Japanese apricot, bitter citrus immature flower, finger citron flower;

Medicinal and edible Chinese medicine extract of the present invention refer to Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, glossy ganoderma, Cordyceps militaris, RHIZOMA POLYGONATI PREPARATA, propolis, dark plum, cape jasmine, dandelion, purslane, hoveniae semoveniae semen, cassia seed, Semen sesami nigrum, black soya bean, rice sprout, Fructus Hordei Germinatus, hawthorn, the root of kudzu vine, peppermint, Buddha's hand, coix seed, Gorgon fruit, lotus seeds, FLOS CHRYSANTHEMI ALBA from Haizhou of China, Flos Magnoliae Officinalis, flower bud of Japanese apricot, bitter citrus immature flower, finger citron flower, French beans, line leaf broom top, eucommia Bark male flower, ampelopsis grossdentata leaf, Euglena, phoenix peony, Qingqian Willow leaf, leaf of Moringa, isodon lophanthoides, Guangdong Cordyceps militarisone wherein, several or whole, adopt biological enzymolysis or prehydrolysis SBE to extract and microencapsulation, spray-dried and cryodesiccated extract all mixes;

2. many kinds of probios: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, research application enteron aisle is had not absorb rifamycin antibiotic former times bright (rifaximin), by suppressing the growth of urease-producing and product ammonium bacteria in enteron aisle, prevent and treat the generation of hepatic encephalopathy;

Multiple probio of the present invention all adopts the probio after microencapsulation, and the probio described in it is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici are wherein a kind of, several or all mix;

Bifidobacterium above a refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above b refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri;

3. small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,

Small peptide of the present invention refers to that maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix;

4. prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, stimulate enterocinesia to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of hepatic encephalopathy;

Prebiotics of the present invention is 2 classes

A. have very strong field planting effect prebiotics to external source probio: Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin extract;

B. common prebiotics: oligoisomaltose, FOS, trehalose, soyabean oligosaccharides, xylo-oligosaccharide, cotton seed compound sugar, stachyose, yeast;

Prebiotics of the present invention is: the extract of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, stachyose, yeast, oligoisomaltose, trehalose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix;

5. carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

Carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, galactolipin, lactose, glucose, maltose, carbohydrate, has the grease of health care, starch, glycogen one wherein, several or all mix;

6. there is the grease of health care to refer to there is health-care effect to the person, and finished product energy can be increased, make the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal); As the street cleaner that fish oil is human vas, can also prevention of arterial sclerosis, apoplexy and heart disease.Fish oil is the diseases such as hypertension, coronary heart disease, headstroke, diabetes, rheumatic arthritis, cancer; Linseed oil has fat-reducing, reduces cholesterol, improves the effects such as renal function; Peony seed oil has reducing blood lipid and hypotensive, strengthens autoimmunity, prevention diabetes, effect of anti-curing cancers; Samara oil prevents and treats hypertension, high fat of blood, effect of the illnesss such as vascular sclerosis;

Of the present invention have the grease of health care to refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix,

7. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;

Amino acid of the present invention refers to Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix;

8. vitamin and mineral matter: vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;

The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;

In the present invention, the addition of vitamin and minerals performs with reference to " special medicine purposes formula food general rule ", now for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

The present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, make product prevent and treat hepatopathy effect and significantly improve compared with the like product of market;

9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

The characteristic of this formula medical science formula food and the following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of hepatopath, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility;

2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", adopt the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio is primary raw material, with prebiotics, carbohydrate, amino acid, the grease having health care, multivitamin and mineral matter for auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect;

3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb quick, complete, hepatopath's desired nutritional can be supplemented rapidly, not increase liver kidney burden;

4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, have and strengthen the effect of resistance of human body, nourishing liver and kidney, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, regulating the function of the liver and spleen in addition, regulating the flow of vital energy are turbid, stopping nausea and vomiting by lowering the adverse flow of QI and prevent hepatic effect;

5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced,

6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, can effectively improve hepatopath's negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa;

7. this prescription have employed this team by the achievement to probio key technology research of field planting mechanism in enteron aisle over nearly 3 year, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio;

8. prebiotics contained in the present invention's formula, by promoting the growth and breeding of probio in intestines, suppress the growth of spoilage organisms, form one protective barrier at intestinal mucosal surface simultaneously, the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted, reduce the absorption of intestinal toxic material, intestines peristalsis can also be promoted, accelerate the discharge of residuals in intestines, constipation can be prevented, and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivator such as small peptide and active polysaccharide has synergy;

9. in the present invention's formula, contained carbohydrate is for human body provides three of heat energy kinds of main nutrients, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) that conveys hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce;

10. in the present invention's formula, the contained grease of health care that has not only has health-care effect to the person, and provides the energy needed for normal life for human body, makes the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal);

Amino acid contained in 11. the present invention's formulas, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development;

12. formula foods of the present invention containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for hepatopath, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element;

Not fatty and cholesterol in 13. the present invention's formulas, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.

Detailed description of the invention

Below by following case study on implementation, the invention will be further described, and it will contribute to understanding the present invention.

Case study on implementation one

Realizing the object of the invention hepatopathy medical science formula food is constitutive character in conjunction with hepatopath, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease multivitamin of health care, several mineral materials to make for auxiliary material;

Fill a prescription by following raw materials according and consumption thereof, the extract of medicine-food two-purpose and new resource food: Cordyceps sinensis 12g, stem of noble dendrobium 12g, glossy ganoderma 11g, Cordyceps militaris 11g, RHIZOMA POLYGONATI PREPARATA 10g, propolis 10g, dark plum 9g, cape jasmine 9g, dandelion 8g, purslane 8g, hoveniae semoveniae semen 7g, cassia seed 7g, Semen sesami nigrum 7g, black soya bean 7g, rice sprout 7g, Fructus Hordei Germinatus 7g, hawthorn 7g, root of kudzu vine 6g, peppermint 6g, Buddha's hand 6g, Gorgon fruit 6g, lotus seeds 6g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 6g, Flos Magnoliae Officinalis 5g, flower bud of Japanese apricot 5g, bitter citrus immature flower 5g, finger citron flower 5g, coix seed 5g, French beans 5g, line leaf broom top4g , eucommia Bark male flower4g , ampelopsis grossdentata leaf4g , Euglena3g , phoenix peony3g , Qingqian Willow leaf3g , leaf of Moringa2g , isodon lophanthoides2g, guangdong Cordyceps militaris1g ,breast mineral salt 1g, multiple probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, there is the grease 100g of health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

During making first will be glossy ganoderma, Cordyceps militaris, RHIZOMA POLYGONATI PREPARATA, propolis, dark plum, cape jasmine, dandelion, purslane, hoveniae semoveniae semen, cassia seed, rice sprout, Fructus Hordei Germinatus, hawthorn, peppermint, Buddha's hand, coix seed, Gorgon fruit, FLOS CHRYSANTHEMI ALBA from Haizhou of China, Flos Magnoliae Officinalis, flower bud of Japanese apricot, bitter citrus immature flower, finger citron flower, line leaf broom top, eucommia Bark male flower, ampelopsis grossdentata leaf, Euglena, phoenix peony, Qingqian Willow leaf, leaf of Moringa, isodon lophanthoidescycloheptaamylose is added after immersion, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, then add biological enzymolysis extract Cordyceps sinensis, Cordyceps militaris, the root of kudzu vine, Semen sesami nigrum, black soya bean, lotus seeds, French beans, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, guangdong Cordyceps militaris,breast mineral salt, small peptide, prebiotics, amino acid, carbohydrate, have the grease of health care, multivitamin and mineral matter to be pulverized and mixed together after carry out pasteurization 1 hour, then the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus mix solid beverage, the granule of making powdery is added, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

Manufacture craft of the present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, product is prevented, and hepatic effect significantly improves compared with the like product of market.

Case study on implementation two

Above-mentioned hepatopathy medical science formula food also comprises following component by weight, the extract of medicine-food two-purpose: dandelion 8g, purslane 8g, hoveniae semoveniae semen 7g, cassia seed 7g, Semen sesami nigrum 7g, black soya bean 7g, rice sprout 7g, Fructus Hordei Germinatus 7g, hawthorn 7g, root of kudzu vine 6g, peppermint 6g, Buddha's hand 6g, Gorgon fruit 6g, lotus seeds 6g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 6g, Flos Magnoliae Officinalis 5g, flower bud of Japanese apricot 5g, bitter citrus immature flower 5g, finger citron flower 5g, coix seed 5g, French beans 5g, line leaf broom top4g , eucommia Bark male flower4g , ampelopsis grossdentata leaf4g , Euglena3g , phoenix peony3g , Qingqian Willow leaf3g , leaf of Moringa2g , isodon lophanthoides2g, guangdong Cordyceps militaris1g ,breast mineral salt 1g, prebiotics 350g, probio 300g, small peptide 150g, several amino acids 100g, carbohydrate 100g, the grease 100g having health care, carbohydrate, the grease having health care, 50g, vitamin and mineral matter 25g.

Case study on implementation three

Above-mentioned hepatopathy medical science formula food also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation four

The certain medical formula food of above-mentioned hepatopathy also comprises following component by weight: prebiotics 700g, small peptide 500g, carbohydrate 300g, multiple probio 300g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation five

Above-mentioned hepatopathy medical science formula food also comprises following component by weight: prebiotics 500g, small peptide 350g, carbohydrate 300g, multiple probio 250g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation six

Above-mentioned hepatopathy medical science formula food also comprises following component by weight: small peptide 350g, prebiotics 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Claims (10)

1. hepatopathy medical science formula food, it is characterized in that the constitutive character in conjunction with hepatopath, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with a kind of, several or whole medicinal and edible Chinese medicine extract essences and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease of health care, multivitamin, several mineral materials to make for auxiliary material;

Fill a prescription by following raw materials according and consumption thereof, the extract of medicine-food two-purpose and new resource food: Cordyceps sinensis 12g, stem of noble dendrobium 12g, glossy ganoderma 11g, Cordyceps militaris 11g, RHIZOMA POLYGONATI PREPARATA 10g, propolis 10g, dark plum 9g, cape jasmine 9g, dandelion 8g, purslane 8g, hoveniae semoveniae semen 7g, cassia seed 7g, Semen sesami nigrum 7g, black soya bean 7g, rice sprout 7g, Fructus Hordei Germinatus 7g, hawthorn 7g, root of kudzu vine 6g, peppermint 6g, Buddha's hand 6g, Gorgon fruit 6g, lotus seeds 6g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 6g, Flos Magnoliae Officinalis 5g, flower bud of Japanese apricot 5g, bitter citrus immature flower 5g, finger citron flower 5g, coix seed 5g, French beans 5g, line leaf broom top4g , eucommia Bark male flower4g , ampelopsis grossdentata leaf4g , Euglena3g , phoenix peony3g , Qingqian Willow leaf3g , leaf of Moringa2g , isodon lophanthoides2g, guangdong Cordyceps militaris1g ,breast mineral salt 1g, multiple probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, there is the grease 100g of health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

During making first will be glossy ganoderma, Cordyceps militaris, RHIZOMA POLYGONATI PREPARATA, propolis, dark plum, cape jasmine, dandelion, purslane, hoveniae semoveniae semen, cassia seed, rice sprout, Fructus Hordei Germinatus, hawthorn, peppermint, Buddha's hand, coix seed, Gorgon fruit, FLOS CHRYSANTHEMI ALBA from Haizhou of China, Flos Magnoliae Officinalis, flower bud of Japanese apricot, bitter citrus immature flower, finger citron flower, line leaf broom top, eucommia Bark male flower, ampelopsis grossdentata leaf, Euglena, phoenix peony, Qingqian Willow leaf, leaf of Moringa, isodon lophanthoidescycloheptaamylose is added after immersion, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, then add biological enzymolysis extract Cordyceps sinensis, Cordyceps militaris, the root of kudzu vine, Semen sesami nigrum, black soya bean, lotus seeds, French beans, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, guangdong Cordyceps militaris,breast mineral salt, small peptide, prebiotics, amino acid, carbohydrate, have the grease of health care, multivitamin and mineral matter to be pulverized and mixed together after carry out pasteurization 1 hour, then the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus mix solid beverage, the granule of making powdery is added, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require;

Manufacture craft of the present invention is characterized in that with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, product is prevented, and hepatic effect significantly improves compared with the like product of market.

2. hepatopathy medical science formula food according to claim 1, is characterized in that described medicine-food two-purpose Chinese herbal medicine extract and new resource food are: glossy ganoderma, Cordyceps militaris, RHIZOMA POLYGONATI PREPARATA, propolis, dark plum, cape jasmine, dandelion, purslane, hoveniae semoveniae semen, cassia seed, rice sprout, Fructus Hordei Germinatus, hawthorn, peppermint, Buddha's hand, coix seed, Gorgon fruit, FLOS CHRYSANTHEMI ALBA from Haizhou of China, Flos Magnoliae Officinalis, flower bud of Japanese apricot, bitter citrus immature flower, finger citron flower, line leaf broom top, eucommia Bark male flower, ampelopsis grossdentata leaf, Euglena, phoenix peony, Qingqian Willow leaf, leaf of Moringa, isodon lophanthoidescycloheptaamylose is added after immersion, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, then add biological enzymolysis extract Cordyceps sinensis, Cordyceps militaris, the root of kudzu vine, Semen sesami nigrum, black soya bean, lotus seeds, French beans, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, guangdong Cordyceps militaris,breast mineral salt one wherein, several or all mix.

3. hepatopathy medical science formula food according to claim 1, is characterised in that and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food according to described formula mixing.

4. hepatopathy medical science formula food according to claim 1, also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295 kJ (70 kcal).

5. hepatopathy medical science formula food according to claim 1, is characterized in that described probio is: Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici, wherein a kind of, several or all mix;

Bifidobacterium above refers to: bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis);

Lactobacillus above refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri.

6. hepatopathy medical science formula food according to claim 1, it is characterized in that described prebiotics is: the extraction mixture of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, trehalose, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix.

7. hepatopathy medical science formula food according to claim 1, is characterized in that described amino acid is: Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.

8. the medical science formula food of hepatopathy according to claim 1, is characterized in that described carbohydrate is that carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

9. hepatopathy medical science formula food according to claim 1, it is characterized in that the described grease of health care that has is: refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix.

10. hepatopathy medical science formula food according to claim 1, is characterized in that described small peptide is: marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix.